patents

Recent patent applications in epigenetics Patent number Description Assignee Inventor Publication date CN104152407 An application of histone deacetylase inhibitors in preparing an osteoblast Stomatological Liu D, Gao P, 11/19/2014 differentiation preparation of odontogenic stem cells; useful for changing Hospital, Tianjin Jia Z, Zhang X, the acetalization of mesenchymal stem cells, changing cell epigenetics by Medical University Xiao R, Feng C, applying to a medicament, treating diseases such as periodontitis or peri- (Tianjin, China) Wang Y implantitis and promoting bone tissue regeneration. CN104069482 Applications of a factor CREB in KDM3A (JHDM2A) - China Agricultural Hu X, Li Y, Li N 10/1/2014 expression regulation and reduction of pig lipid deposition. Through University (Beijing) overexpression of CREB, improvement of the CREB phosphorylation level or promotion of a combination of pig CREB-binding and phosphory- lated CREB, KDM3A gene expression in pigs is upregulated, thus regulat- ing lipid-metabolism pathways from the epigenetics and reducing pig lipid deposition. US20140212873 Screening of individuals and populations for epigenetic profiles associated La Trobe University Godler D 7/31/2014 with a pathological condition. Epigenetic profiles are disclosed from the (Melbourne, Victoria, following sites in the FMR1 gene: FREE3; intron 2; an intron, intron-exon Australia), boundary and/or splicing region downstream of intron 2; and a site within Murdoch Children’s the FREE2 portion of intron 1 in combination with a full mutation. Research Institute (Parkville, Victoria, Australia) US20140170228 Combination-therapy methods of treating a proliferative disease (such as Abraxis BioScience Desai NP, 6/19/2014 cancer) comprising a first therapy comprising administering to an indi- (Los Angeles) Soon-Shiong P vidual an effective amount of a taxane in a nanoparticle composition and a second therapy that may include the administration of an effective amount of at least one other agent that modifies the epigenetics in a cell. US20140080162 Methods of assaying the activity of enzymes based on measurement of Almac Sciences Cotton G, 3/20/2014 fluorescence lifetime (FLT). (Edinburgh) Dunsmore C KR101363412 A method for regulating domain rearranged methyltransferase (DRM) SNU R&DB Foundation Shin CS, Park JJ, 3/19/2014 protein activity in a plant; useful for improving traits of food crops, forage (Seoul) Hwang DG crops, floriculture crops, horticultural crops and energy crops and available for various medical applications, such as differentiation of cancer cells and neural cells, which are mainly involved in epigenetic information. US20130323742 Methods and apparatus for separating, concentrating and/or detecting University of British Marziali A, 12/5/2013 molecules on the basis of differences in binding affinity to a probe; can be Columbia (Vancouver, Pel J, used in fields such as epigenetics or oncology to selectively concentrate or British Columbia, Thompson JD, detect the presence of specific biomolecules or differentially modified bio- Canada) Shibahara G molecules, provide diagnostics for disorders such as fetal genetic disorders or detect biomarkers in cancer, organ failure, disease states or infection. US20130283404 Compositions and methods for the diagnosis, monitoring, treatment and/ Regents of the Richardson BC, 10/24/2013 or prevention of autoimmune disease (e.g., lupus) based on a causal con- University of Michigan Hewagama A, nection with various epigenetic markers (e.g., demethylation, (Ann Arbor, MI, USA) Gorelik G overexpression of lupus markers or nitration of PKCd in response to oxida- Nature America, Inc. All rights reserved. America, Inc. © 201 5 Nature tive stress). US20130129668 Diagnosis and treatment of arthritis using epigenetics methods, composi- Regents of the Firestein G, 5/23/2013 tions and kits for evaluating a diagnosis, prognosis or response to treatment University of California Nakano K of a subject with a disorder such as rheumatoid arthritis or osteoarthritis. (Oakland, CA, USA) npg Source: US Patent and Trademark Office (http://www.uspto.gov); European Patent Office (http://www.epo.org).

nature biotechnology volume 33 NUMBER 4 APRIL 2015 353