Gordon, Siamon
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Mothers in Science
The aim of this book is to illustrate, graphically, that it is perfectly possible to combine a successful and fulfilling career in research science with motherhood, and that there are no rules about how to do this. On each page you will find a timeline showing on one side, the career path of a research group leader in academic science, and on the other side, important events in her family life. Each contributor has also provided a brief text about their research and about how they have combined their career and family commitments. This project was funded by a Rosalind Franklin Award from the Royal Society 1 Foreword It is well known that women are under-represented in careers in These rules are part of a much wider mythology among scientists of science. In academia, considerable attention has been focused on the both genders at the PhD and post-doctoral stages in their careers. paucity of women at lecturer level, and the even more lamentable The myths bubble up from the combination of two aspects of the state of affairs at more senior levels. The academic career path has academic science environment. First, a quick look at the numbers a long apprenticeship. Typically there is an undergraduate degree, immediately shows that there are far fewer lectureship positions followed by a PhD, then some post-doctoral research contracts and than qualified candidates to fill them. Second, the mentors of early research fellowships, and then finally a more stable lectureship or career researchers are academic scientists who have successfully permanent research leader position, with promotion on up the made the transition to lectureships and beyond. -
Pnas11052ackreviewers 5098..5136
Acknowledgment of Reviewers, 2013 The PNAS editors would like to thank all the individuals who dedicated their considerable time and expertise to the journal by serving as reviewers in 2013. Their generous contribution is deeply appreciated. A Harald Ade Takaaki Akaike Heather Allen Ariel Amir Scott Aaronson Karen Adelman Katerina Akassoglou Icarus Allen Ido Amit Stuart Aaronson Zach Adelman Arne Akbar John Allen Angelika Amon Adam Abate Pia Adelroth Erol Akcay Karen Allen Hubert Amrein Abul Abbas David Adelson Mark Akeson Lisa Allen Serge Amselem Tarek Abbas Alan Aderem Anna Akhmanova Nicola Allen Derk Amsen Jonathan Abbatt Neil Adger Shizuo Akira Paul Allen Esther Amstad Shahal Abbo Noam Adir Ramesh Akkina Philip Allen I. Jonathan Amster Patrick Abbot Jess Adkins Klaus Aktories Toby Allen Ronald Amundson Albert Abbott Elizabeth Adkins-Regan Muhammad Alam James Allison Katrin Amunts Geoff Abbott Roee Admon Eric Alani Mead Allison Myron Amusia Larry Abbott Walter Adriani Pietro Alano Isabel Allona Gynheung An Nicholas Abbott Ruedi Aebersold Cedric Alaux Robin Allshire Zhiqiang An Rasha Abdel Rahman Ueli Aebi Maher Alayyoubi Abigail Allwood Ranjit Anand Zalfa Abdel-Malek Martin Aeschlimann Richard Alba Julian Allwood Beau Ances Minori Abe Ruslan Afasizhev Salim Al-Babili Eric Alm David Andelman Kathryn Abel Markus Affolter Salvatore Albani Benjamin Alman John Anderies Asa Abeliovich Dritan Agalliu Silas Alben Steven Almo Gregor Anderluh John Aber David Agard Mark Alber Douglas Almond Bogi Andersen Geoff Abers Aneel Aggarwal Reka Albert Genevieve Almouzni George Andersen Rohan Abeyaratne Anurag Agrawal R. Craig Albertson Noga Alon Gregers Andersen Susan Abmayr Arun Agrawal Roy Alcalay Uri Alon Ken Andersen Ehab Abouheif Paul Agris Antonio Alcami Claudio Alonso Olaf Andersen Soman Abraham H. -
Siamon Gordon: a Half-Century Fascination with Macrophages
PEOPLE & IDEAS Siamon Gordon: A half-century fascination with macrophages Stephanie Houston Siamon Gordon is a Glaxo Wellcome Professor Emeritus of Cellular Pathology at the University of Oxford and a fellow of the Royal Society. Throughout his career, Siamon has focused on macrophages, and his work led to the identification of the pan- macrophage marker F4/80 and the description of a role for Dectin-1 in the innate recognition of β-glucans. I caught up with Siamon to discuss his career path and his thoughts on macrophages. Downloaded from http://rupress.org/jem/article-pdf/217/7/e20191069/1138520/jem_20191069.pdf by guest on 26 September 2021 Background plasma membrane receptors and respon- My parents immigrated to South Africa siveness to change in their environment, from Lithuania in 1930. Due to the Depres- they support specific organ functions and sion, my father, trained as a rabbi, had to promote homeostasis beyond immunity and move to the small village of Darling, 50 host defense. miles from Cape Town, to serve a scattered Jewish community on the West Coast. I Where and with whom have you studied spoke Afrikaans and went to a local school (undergraduate, graduate, postdoc)? until the age of 15 before moving to an In 1965, I was fortunate to meet my doctoral English language school in Cape Town for supervisor, Zanvil (Zan) Cohn, founder of the final 2 yr of high school. I studied med- cellular immunology at the Rockefeller icine at the University of Cape Town, grad- University, mentor of a generation of mac- uating in 1961, completed my residency at rophage investigators, and editor of the Groote Schuur Hospital, and left for further Journal of Experimental Medicine.Heen- research experience abroad in 1964. -
Pnas11052ackreviewers 5098..5136
Acknowledgment of Reviewers, 2013 The PNAS editors would like to thank all the individuals who dedicated their considerable time and expertise to the journal by serving as reviewers in 2013. Their generous contribution is deeply appreciated. A Harald Ade Takaaki Akaike Heather Allen Ariel Amir Scott Aaronson Karen Adelman Katerina Akassoglou Icarus Allen Ido Amit Stuart Aaronson Zach Adelman Arne Akbar John Allen Angelika Amon Adam Abate Pia Adelroth Erol Akcay Karen Allen Hubert Amrein Abul Abbas David Adelson Mark Akeson Lisa Allen Serge Amselem Tarek Abbas Alan Aderem Anna Akhmanova Nicola Allen Derk Amsen Jonathan Abbatt Neil Adger Shizuo Akira Paul Allen Esther Amstad Shahal Abbo Noam Adir Ramesh Akkina Philip Allen I. Jonathan Amster Patrick Abbot Jess Adkins Klaus Aktories Toby Allen Ronald Amundson Albert Abbott Elizabeth Adkins-Regan Muhammad Alam James Allison Katrin Amunts Geoff Abbott Roee Admon Eric Alani Mead Allison Myron Amusia Larry Abbott Walter Adriani Pietro Alano Isabel Allona Gynheung An Nicholas Abbott Ruedi Aebersold Cedric Alaux Robin Allshire Zhiqiang An Rasha Abdel Rahman Ueli Aebi Maher Alayyoubi Abigail Allwood Ranjit Anand Zalfa Abdel-Malek Martin Aeschlimann Richard Alba Julian Allwood Beau Ances Minori Abe Ruslan Afasizhev Salim Al-Babili Eric Alm David Andelman Kathryn Abel Markus Affolter Salvatore Albani Benjamin Alman John Anderies Asa Abeliovich Dritan Agalliu Silas Alben Steven Almo Gregor Anderluh John Aber David Agard Mark Alber Douglas Almond Bogi Andersen Geoff Abers Aneel Aggarwal Reka Albert Genevieve Almouzni George Andersen Rohan Abeyaratne Anurag Agrawal R. Craig Albertson Noga Alon Gregers Andersen Susan Abmayr Arun Agrawal Roy Alcalay Uri Alon Ken Andersen Ehab Abouheif Paul Agris Antonio Alcami Claudio Alonso Olaf Andersen Soman Abraham H. -
Fusion #5A:Fusion #5 13/11/07 09:32 Page 1
Fusion #5a:Fusion #5 13/11/07 09:32 Page 1 fusion 5 Fusion #5a:Fusion #5 13/11/07 09:32 Page 2 12 / FUSION . MICHAELMAS 2006 Bird flu vaccines and reverse genetics Influenza is rightly perceived as a significant health risk, and the spread of H5N1 (bird flu) has provoked alarm as it spreads across the globe. The groups of Professor George Brownlee, FRS and Ervin Fodor have for the past decade been working on understanding the molecular mechanisms underlying the influenza virus replication and adaptation from one species to another. Here, post-doctoral researcher Dr Ruth Harvey explains their approach. Influenza virus was first isolated in 1933, and it ion channel activity required by the virus for the still remains a public health and economic problem release of its RNA into the host cell, but today. Since its isolation there have been two resistance to this class of drugs is very common. Influenza virus binding to major pandemics, ‘Asian flu’ in 1957 (H2N2 The new neuraminidase inhibitors (such as infected cell via subtype) and ‘Hong Kong’ flu in 1968 (H3N2 Relenza and Tamiflu) block release of new virus Haemagglutinin spikes on subtype), estimated to have killed a total of 1.5 particles from infected cells, but these drugs virus surface. million people. But we should not forget the only work if administered in the first 72 hours infamous ‘Spanish flu’ in 1918 (H1N1 subtype) after infection and there have also been reports that reportedly killed an estimated 20 to 40 million of resistance starting to emerge. We still need people. -
Unravelling Mononuclear Phagocyte Heterogeneity
PERSPECTIVES phenotypical modulation7. Even in the VIEWPOINT absence of inflammation and infection, macrophage populations8 display bewildering Unravelling mononuclear phagocyte heterogeneity. For example, numerous mono nuclear phagocyte populations are found in heterogeneity the mouse spleen, including red and white pulp macrophages, ‘reservoirs’ of mobilizable monocytes9, marginal zone metallophilic Frédéric Geissmann, Siamon Gordon, David A. Hume, Allan M. Mowat and macrophages and outer zone macrophages, Gwendalyn J. Randolph and further complexity arises from the presence of resident, motile and migratory Abstract | When Ralph Steinman and Zanvil Cohn first described dendritic cells activated DCs in the same organ10. (DCs) in 1973 it took many years to convince the immunology community that Another problem is the marked hetero these cells were truly distinct from macrophages. Almost four decades later, the geneity in the turnover and variable lifespan DC is regarded as the key initiator of adaptive immune responses; however, of macrophages — hours to weeks — distinguishing DCs from macrophages still leads to confusion and debate in the depending on stimulation, programmed cell death and/or injury. In the mouse, field. Here, Nature Reviews Immunology asks five experts to discuss the issue of genetic manipulation and intravital imaging heterogeneity in the mononuclear phagocyte system and to give their opinion on methods make it possible to study direct the importance of defining these cells for future research. precursor–product relationships. However, the dynamics of tissue populations in humans remain largely unexplored. Myeloid cells are infamously Recent in vivo experiments in mice have heterogeneous. Do you think that this increased our understanding of the develop Gwendalyn J. Randolph.