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ANNEX II, Last Update: 06/07/2021 LIST of SUBSTANCES PROHIBITED in COSMETIC PRODUCTS

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ANNEX II, Last Update: 06/07/2021 LIST of SUBSTANCES PROHIBITED in COSMETIC PRODUCTS File creation date: 25/09/2021 ANNEX II, Last update: 06/07/2021 LIST OF SUBSTANCES PROHIBITED IN COSMETIC PRODUCTS Reference Substance identification number Chemical name / INN CAS Number EC Number Update Date 1 N-(5-Chlorobenzoxazol-2-yl)acetamide 35783-57-4 - 17/10/2010 2 (2-Acetoxyethyl)trimethylammonium hydroxide (Acetylcholine) and its salts 51-84-3 200-128-9 17/10/2010 3 Deanol aceglumate (INN) 3342-61-8 222-085-5 15/10/2010 4 Spironolactone (INN) 52-01-7 200-133-6 15/10/2010 5 [4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid (Tiratricol (INN)) and its salts 51-24-1 200-086-1 17/10/2010 6 Methotrexate (INN) 59-05-2 200-413-8 15/10/2010 7 Aminocaproic acid (INN) and its salts 60-32-2 200-469-3 17/10/2010 8 Cinchophen (INN), its salts, derivatives and salts of these derivatives 132-60-5 / 205-067-1 / 17/10/2010 5949-18-8 227-710-5 9 Thyropropic acid (INN) and its salts 51-26-3 - 17/10/2010 10 Trichloroacetic acid 76-03-9 200-927-2 15/10/2010 11 Aconitum napellus L. (leaves, roots and galenical preparations) 84603-50-9 283-252-6 15/10/2010 12 Aconitine (principal alkaloid of Aconitum napellus L.) and its salts 302-27-2 206-121-7 15/10/2010 13 Adonis vernalis L. and its preparations 84649-73-0 283-458-6 15/10/2010 14 Epinephrine (INN) 51-43-4 200-098-7 15/10/2010 15 Rauwolfia serpentia L., alkaloids and their salts 90106-13-1 290-234-1 17/10/2010 16 Alkyne alcohols, their esters, ethers and salts - - 17/10/2010 17 Isoprenaline (INN) 7683-59-2 231-687-7 15/10/2010 18 Allyl isothiocyanate 57-06-7 200-309-2 15/10/2010 19 Alloclamide (INN) and its salts 5486-77-1 - 17/10/2010 20 Nalorphine (INN), its salts and ethers 62-67-9 200-546-1 17/10/2010 21 Sympathicomimetic amines acting on the central nervous system: any substance contained in the first list of medicaments which are subject to medical prescription and 300-62-9 206-096-2 09/03/2011 referred to in Resolution AP (69) 2 of the Council of Europe 22 4,4'-Methylene bis(2-chloroaniline) and its salts; 2,2'-Dichloro-4,4'-methylenedianiline and its salts 101-14-4 202-918-9 04/10/2016 22 Aniline, its salts and its halogenated and sulphonated derivatives 62-53-3 200-539-3 09/07/2019 23 Betoxycaine (INN) and its salts 3818-62-0 - 17/10/2010 24 Zoxazolamine (INN) 61-80-3 200-519-4 17/10/2010 25 Procainamide (INN), its salts and derivatives 51-06-9 200-078-8 17/10/2010 26 Benzidine 92-87-5 202-199-1 20/10/2010 27 Tuaminoheptane (INN), its isomers and salts 123-82-0 204-655-5 17/10/2010 Page 1/69 Reference Substance identification number Chemical name / INN CAS Number EC Number Update Date 28 Octodrine (INN) and its salts 543-82-8 208-851-1 17/10/2010 29 2-Amino-1,2-bis(4-methoxyphenyl)ethanol and its salts 530-34-7 - 17/10/2010 30 1,3-Dimethylpentylamine and its salts 105-41-9 203-296-1 15/10/2010 31 4-Aminosalicylic acid and its salts 65-49-6 200-613-5 15/10/2010 32 Toluidines, their isomers, salts and halogenated and sulphonated derivatives 26915-12-8 248-105-2 17/10/2010 33 Xylidines, their isomers, salts and halogenated and sulphonated derivatives 1300-73-8 215-091-4 17/10/2010 34 Imperatorin (9-(3-methylbut-2-enyloxy)furo[3,2-g]chromen-7-one) 482-44-0 207-581-1 15/10/2010 35 Ammi majus L. and its galenical preparations 90320-46-0 291-072-4 17/10/2010 36 2,3-Dichloro-2-methylbutane 507-45-9 - 15/10/2010 37 Substances with androgenic effect 15/10/2010 38 Anthracene oil 120-12-7 204-371-1 17/10/2010 38 Distillates (coal tar), pitch 101316-49-8 309-855-7 04/10/2016 38 Distillates (coal tar), pitch, heavy oils 91995-51-6 295-312-9 04/10/2016 38 Distillates (coal tar), pitch, pyrene fraction 91995-52-7 295-313-4 04/10/2016 39 Antibiotics 17/10/2010 40 Antimony and its compound 7440-36-0 231-146-5 17/10/2010 41 Apocynum cannabium L. and its preparations 84603-51-0 283-253-1 15/10/2010 42 Apomorphine ((R)-5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol)) and its salts 58-00-4 200-360-0 17/10/2010 43 Arsenic acid and its salts 7778-44-1 - 23/11/2016 43 Arsenic and its compounds 7440-38-2 231-148-6 07/01/2011 44 Atropa belladonna L. and its preparations 8007-93-0 232-365-9 15/10/2010 45 Atropine, its salts and derivatives 51-55-8 200-104-8 15/10/2010 46 Barium salts, with the exception of barium sulphide under the conditions laid down in Annex III and of barium sulfate, lakes, salts and pigments prepared from the 17/10/2010 colouring agents when listed in Annex IV 46 Beryllium compounds with the exception of aluminium beryllium silicates 7440-41-7 - 23/11/2016 47 Benzene 71-43-2 200-753-7 28/10/2010 47 Distillates (petroleum), C7-9, C8-rich, hydrodesulfurized dearomatized, if it contains > 0.1% w/w benzene 101316-56-7 309-862-5 04/10/2016 47 Extract residues (coal tar), benzole fraction alk., acid ext., if it contains > 0.1% w/w benzene 101316-63-6 309-868-8 04/10/2016 47 Extract residues (coal), light oil alk., acid ext., indene fraction, if it contains > 0.1% w/w benzene 101316-62-5 309-867-2 04/10/2016 47 Hydrocarbon oils, arom., mixed with polyethylene and polypropylene, pyrolyzed, light oil fraction, if it contains > 0.1% w/w benzene 100801-63-6 309-745-9 04/10/2016 47 Hydrocarbons, C6-8, hydrogenated sorption-dearomatized, toluene raffination, if it contains > 0.1% w/w benzene 101316-66-9 309-870-9 04/10/2016 47 Hydrocarbons, C6-rich, hydrotreated light naphtha distillates, solvent-refined, if it contains > 0.1% w/w benzene 101316-67-0 309-871-4 04/10/2016 47 Naphtha (petroleum), hydrodesulfurized full-range coker, if it contains > 0.1% w/w benzene 101316-76-1 309-879-8 04/10/2016 Page 2/69 Reference Substance identification number Chemical name / INN CAS Number EC Number Update Date 47 Tar acids, brown-coal, crude, if it contains > 0.1% w/w benzene 101316-86-3 309-888-7 04/10/2016 48 Benzimidazol-2(3H)-one 615-16-7 210-412-4 15/10/2010 49 Benzazepines and benzodiazepines 12794-10-4 - 17/10/2010 50 1-Dimethylaminomethyl-1-methylpropyl benzoate (amylocaine) and its salts 644-26-8 211-411-1 15/10/2010 51 2,2,6-Trimethyl-4-piperidyl benzoate (eucaine) and its salts 500-34-5 - 17/10/2010 52 Isocarboxazid (INN) 59-63-2 200-438-4 17/10/2010 53 Bendroflumethiazide (INN) and its derivatives 73-48-3 200-800-1 17/10/2010 54 Beryllium and its compounds 7440-41-7 231-150-7 17/10/2010 55 Bromine, elemental 7726-95-6 231-778-1 15/10/2010 56 Bretylium tosilate (INN) 61-75-6 200-516-8 17/10/2010 57 Carbromal (INN) 77-65-6 201-046-6 17/10/2010 58 Bromisoval (INN) 496-67-3 207-825-7 17/10/2010 59 Brompheniramine (INN) and its salts 86-22-6 201-657-8 17/10/2010 60 Benzilonium bromide (INN) 1050-48-2 213-885-5 17/10/2010 61 Tetrylammonium bromide (INN) 71-91-0 200-769-4 15/10/2010 62 Brucine 357-57-3 206-614-7 15/10/2010 63 Tetracaine (INN) and its salts 94-24-6 202-316-6 17/10/2010 64 Mofebutazone (INN) 2210-63-1 218-641-1 17/10/2010 65 Tolbutamide (INN) 64-77-7 200-594-3 17/10/2010 66 Carbutamide (INN) 339-43-5 206-424-4 17/10/2010 67 Phenylbutazone (INN) 50-33-9 200-029-0 17/10/2010 68 Cadmium chloride 10108-64-2 233-296-7 04/10/2016 68 Cadmium sulphate 10124-36-4 233-331-6 04/10/2016 69 Cantharides, Cantharis vesicatoria 92457-17-5 296-298-7 15/10/2010 70 Cantharidine 56-25-7 200-263-3 17/10/2010 71 Phenprobamate (INN) 673-31-4 211-606-1 17/10/2010 72 Nitroderivatives of carbazole 15/10/2010 73 Carbon disulphide 75-15-0 200-843-6 15/10/2010 74 Catalase 9001-05-2 232-577-1 03/08/2020 75 Cephaeline and its salts 483-17-0 207-591-6 15/10/2010 76 Chenopodium ambrosioides L. (essential oil) 8006-99-3 - 17/10/2010 77 2,2,2-Trichloroethane-1,1-diol 302-17-0 206-117-5 15/10/2010 78 Chlorine 7782-50-5 231-959-5 15/10/2010 Page 3/69 Reference Substance identification number Chemical name / INN CAS Number EC Number Update Date 79 Chlorpropamide (INN) 94-20-2 202-314-5 17/10/2010 80 Diphenoxylate (INN) hydrochloride 3810-80-8 223-287-6 15/10/2010 81 4-Phenylazophenylene-1,3-diamine citrate hydrochloride (Chrysoidine citrate hydrochloride) 5909-04-6 - 17/10/2010 82 Chlorzoxazone (INN) 95-25-0 202-403-9 17/10/2010 83 2-Chloro-6-methylpyrimidin-4-yldimethylamine (crimidine-ISO) 535-89-7 208-622-6 17/10/2010 84 Chlorprothixene (INN) and its salts 113-59-7 204-032-8 17/10/2010 85 Clofenamide (INN) 671-95-4 211-588-5 17/10/2010 86 N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts 126-85-2 - 17/10/2010 87 Chlormethine (INN) and its salts 51-75-2 200-120-5 17/10/2010 88 Cyclophosphamide (INN) and its salts 50-18-0 200-015-4 17/10/2010 89 Mannomustine (INN) and its salts 576-68-1 209-404-3 17/10/2010 90 Butanilicaine (INN) and its salts 3785-21-5 - 17/10/2010 91 Chlormezanone (INN) 80-77-3 201-307-4 17/10/2010 92 Triparanol (INN) 78-41-1 201-115-0 17/10/2010 93 2-[2-(4-Chlorophenyl)-2-phenylacetyl]indan 1,3-dione (chlorophacinone - ISO) 3691-35-8 223-003-0 15/10/2010 94 Chlorphenoxamine (INN) 77-38-3 - 17/10/2010 95 Phenaglycodol (INN) 79-93-6 201-235-3 17/10/2010 96 Chloroethane 75-00-3 200-830-5 15/10/2010 97 Chromium (VI) compounds, with the exception of barium chromate and of compounds specified elsewhere in this Annex 18540-29-9 - 23/11/2016 97 Chromium; chromic acid and its salts 7440-47-3 231-157-5 17/10/2010 97 Zinc chromates including zinc potassium chromate 7440-47-3 231-157-5 04/10/2016 98 Claviceps purpurea Tul., its alkaloids and galenical preparations 84775-56-4 283-885-8 15/10/2010 99 Conium maculatum L.
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