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For People Taking DESCOVY® Combination Tablets

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For People Taking DESCOVY® Combination Tablets Gran Tokyo South Tower, 1-9-2 Marunouchi, Chiyoda-ku, Tokyo, 100-6616 Tokyo, 1-9-2Marunouchi,Chiyoda-ku, South Tower, Tokyo Gran Inc. Gilead Sciences, Contact Information Contact DVY19DS0099PA Created in December 2019 inDecember Created DVY19DS0099PA CombinationTablets TakingDESCOVY National CenterforGlobalHealthandMedicine For People Director oftheAIDSClinicalCenter Shinichi Oka Editorial Supervisor ® Taking DESCOVY What to do if you miss How to take DESCOVY E ects of DESCOVY Introduction / Combination Tablets Side e ects a dose of DESCOVY during pregnancy / Combination Tablets / Combination Tablets Combination Tablets Table of contents Additional information Precautions Introduction For People Taking DESCOVY Combination Tablets Table of contents / Introduction of contents Table This leaflet was created for people who take DESCOVY Combination Tablets. This leaflet includes information about the characteristics of DESCOVY 01 Introduction Combination Tablets, how to take DESCOVY Combination Tablets, what to do if 3 What are DESCOVY Combination Tablets? DESCOVY you forget to take DESCOVY Combination Tablets, the side eects of DESCOVY Characteristics of DESCOVY Combination Tablets Combination Tablets, and precautions for taking DESCOVY Combination Tablets. E ects of DESCOVY Combination Tablets E ects of E ects Tablets Combination Read this leaflet thoroughly before taking DESCOVY Combination Tablets. 5 How should DESCOVY Combination Tablets be taken? Concomitant use of DESCOVY Combination Tablets with other medicines A medical decision needs to be made based on your circumstances before starting the administration of DESCOVY Combination Tablets. 9 What should you do if you miss a dose of DESCOVY Combination Tablets? Listen carefully to the explanation provided by your healthcare providers (physicians, nurses and pharmacists) and follow their instructions. 10 Precautions for taking DESCOVY DESCOVY take to How Tablets Combination Combination Tablets If you have any questions about the administration of DESCOVY Combination If you are infected by hepatitis B virus Tablets, consult your healthcare providers (physicians, nurses and pharmacists). If you have symptoms of lactic acidosis If liver dysfunction occurs 11 What are the side e ects of DESCOVY What to do if you miss miss do if you to What a dose of DESCOVY / Tablets Combination Precautions Combination Tablets? 13 Taking DESCOVY Combination Tablets during pregnancy? Breast-feeding If you would like to know more about HIV infection Side e ects 14 Is there anything else you should know? This leaflet is a revised Japanese version of the “Patient Information of DESCOVY” which accompanies “DESCOVY Precautions in everyday life Full Prescribing Information” in the U.S. How to store DESCOVY Combination Tablets The content was compiled under the supervision of Dr. Shinichi Oka (Director of AIDS Clinical Center, National How to uncap the container of DESCOVY Combination Tablets Center for Global Health and Medicine) 1 2 DESCOVY Taking Tablets Combination / during pregnancy information Additional Introduction For People Taking DESCOVY Combination Tablets Table of contents / Introduction of contents Table This leaflet was created for people who take DESCOVY Combination Tablets. This leaflet includes information about the characteristics of DESCOVY 01 Introduction Combination Tablets, how to take DESCOVY Combination Tablets, what to do if 3 What are DESCOVY Combination Tablets? DESCOVY you forget to take DESCOVY Combination Tablets, the side eects of DESCOVY ● Characteristics of DESCOVY Combination Tablets Combination Tablets, and precautions for taking DESCOVY Combination Tablets. ● E ects of DESCOVY Combination Tablets E ects of E ects Tablets Combination Read this leaflet thoroughly before taking DESCOVY Combination Tablets. 5 How should DESCOVY Combination Tablets be taken? ● Concomitant use of DESCOVY Combination Tablets with other medicines A medical decision needs to be made based on your circumstances before starting the administration of DESCOVY Combination Tablets. 9 What should you do if you miss a dose of DESCOVY Combination Tablets? Listen carefully to the explanation provided by your healthcare providers (physicians, nurses and pharmacists) and follow their instructions. 10 Precautions for taking DESCOVY DESCOVY take to How Tablets Combination Combination Tablets If you have any questions about the administration of DESCOVY Combination ● If you are infected by hepatitis B virus ● Tablets, consult your healthcare providers (physicians, nurses and pharmacists). If you have symptoms of lactic acidosis ● If liver dysfunction occurs 11 What are the side e ects of DESCOVY What to do if you miss miss do if you to What a dose of DESCOVY / Tablets Combination Precautions Combination Tablets? 13 Taking DESCOVY Combination Tablets during pregnancy? ● Breast-feeding ● If you would like to know more about HIV infection Side e ects 14 Is there anything else you should know? ● This leaflet is a revised Japanese version of the “Patient Information of DESCOVY” which accompanies “DESCOVY Precautions in everyday life Full Prescribing Information” in the U.S. ● How to store DESCOVY Combination Tablets The content was compiled under the supervision of Dr. Shinichi Oka (Director of AIDS Clinical Center, National ● How to uncap the container of DESCOVY Combination Tablets Center for Global Health and Medicine) 1 2 DESCOVY Taking Tablets Combination / during pregnancy information Additional What are DESCOVY Combination Tablets? / Introduction of contents Table DESCOVY is a medicine for HIV infection that reduces the amount of the virus in the blood1). Eects of DESCOVY Combination Tablets When DESCOVY Combination Tablets are administered and HIV activity in the blood is suppressed, Emtricitabine and tenofovir alafenamide contained in DESCOVY Combination Tablets suppress immune-compromised patients recover some of their immune function and are less likely to acquire the activity of HIV reverse transcriptase3), which is necessary for HIV to multiply in the body, and opportunistic infections2). prevent the growth of HIV. DESCOVY Note 3) HIV reverse transcriptase Note 1) Amount of virus in the blood Herpesvirus infection of E ects Tablets Combination A type of enzyme that works when HIV multiplies in the body; A specific The amount of virus in the blood is represented by the viral count in 1 mL Candida esophagitis type of enzyme contained in the virus of plasma. It indicates the treatment start time and/or the eects of the anti-HIV medicines. The goal of treatment is to maintain a viral concentration that is below the detection limit over a long period of time. Note 2) Opportunistic infections HIV Signifies infections caused by weakly pathogenic microorganisms CCR5 inhibitor Integrase inhibitor that do not cause infections in people with normal immune function. Opportunistic infections include candida esophagitis, herpesvirus Mycobacterium Absorption/fusion infection, and Mycobacterium avium complex (MAC) infection. avium CD4 receptor DESCOVY take to How Tablets Combination complex (MAC) infection Invasion Integration DNA synthesis Characteristics of DESCOVY Combination Tablets HIV RNA mRNA Reverse DESCOVY Combination Tablets contain two types of nucleoside reverse transcriptase inhibitors. One is transcription Assembly Budding/release emtricitabine, and the other is tenofovir alafenamide. You can take two types of medicines with a once miss do if you to What a dose of DESCOVY / Tablets Combination Precautions Protein daily administration of only one tablet of DESCOVY, thus reducing the burden of administration. For actual Protein synthesis degradation/ modification treatment, other anti-HIV medicines are usually taken with DESCOVY Combination Tablets. Non-nucleoside reverse transcriptase inhibitor DESCOVY does not completely cure HIV infection or AIDS through short-term administration, but CD4 cell Protease inhibitor suppresses HIV activity through continued administration. Continued treatment is required, while taking Nucleoside reverse transcriptase inhibitor precautions against opportunistic infections and other symptoms. HIV reverse transcriptase DESCOVY Combination Tablets HIV protease Emtricitabine HIV integrase Side e ects Tenofovir alafenamide In addition to nucleoside reverse transcriptase inhibitors, anti-HIV medicines include non-nucleoside reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, and CCR5 inhibitors, which respectively have dierent mechanisms of action. In the treatment of HIV infection, DESCOVY Combination Tablets are usually used in combination with these other medicines. 3 4 DESCOVY Taking Tablets Combination / during pregnancy information Additional What are DESCOVY Combination Tablets? / Introduction of contents Table DESCOVY is a medicine for HIV infection that reduces the amount of the virus in the blood1). Eects of DESCOVY Combination Tablets When DESCOVY Combination Tablets are administered and HIV activity in the blood is suppressed, Emtricitabine and tenofovir alafenamide contained in DESCOVY Combination Tablets suppress immune-compromised patients recover some of their immune function and are less likely to acquire the activity of HIV reverse transcriptase3), which is necessary for HIV to multiply in the body, and opportunistic infections2). prevent the growth of HIV. DESCOVY Note 3) HIV reverse transcriptase Note 1) Amount of virus in the blood Herpesvirus infection of E ects Tablets Combination A type of enzyme that works when HIV multiplies in the
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