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SCI-Kayitli-Yayin-2008.Pdf ŀ İçindekiler TEMEL TIP BİLİMLERİ Anatomi Anabilim Dalı Biyofizik Anabilim Dalı Biyoistatistik ve Tıp Bilişimi Anabilim Dalı Fizyoloji Anabilim Dalı Histoloji ve Embriyoloji Anabilim Dalı Tıbbi Biyokimya Anabilim Dalı Tıbbi Biyoloji Anabilim Dalı Tıbbi Mikrobiyoloji Anabilim Dalı Tıp Eğitimi Anabilim Dalı Tıp Tarihi ve Etik Anabilim Dalı DAHİLİ TIP BİLİMLERİ Acil Tıp Anabilim Dalı Aile Hekimliği Anabilim Dalı Çocuk Sağlığı ve Hastalıkları Anabilim Dalı Deri ve Zührevi Hastalıklar Anabilim Dalı Enfeksiyon Hastalıkları Anabilim Dalı Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı İç Hastalıkları Anabilim Dalı Kardiyoloji Anabilim Dalı Nöroloji Anabilim Dalı Nükleer Tıp Anabilim Dalı Radyasyon Onkolojisi Radyoloji Anabilim Dalı Tıbbi Farmakoloji Anabilim Dalı CERRAHİ TIP BİLİMLERİ Anestezyoloji ve Reanimasyon Anabilim Dalı Beyin ve Sinir Cerrahisi Anabilim Dalı Çocuk Cerrahisi Anabilim Dalı Genel Cerrahi Anabilim Dalı Göz Hastalıkları Anabilim Dalı Kadın Hastalıkları ve Doğum Anabilim Dalı Kalp Damar Cerrahisi Anabilim Dalı Kulak, Burun ve Boğaz Hastalıkları Anabilim Dalı Plastik ve Rekonstrüktif Estetik Cerrahi Anabilim Dalı Tıbbi Patoloji Anabilim Dalı Üroloji Anabilim Dalı ŀ Anatomi Anabilim Dalı -2008 1-Yildirim FB, Sarikcioglu L: Augusta Dejerine-Klumpke (1859-1927) and her eponym.J Neurol Neurosurg Psychiatry79: 102, 2008. 2-Sarikcioglu L,Yildirim FB: Area postrema: one of the terms described by Magnus Gustaf Retzius.J Hist Neurosci17: 109-110, 2008. 3-Sarikcioglu L, Altun U, Suzen B, Oguz N: The evolution of the terminology of the basal ganglia, or are they nuclei.J Hist Neurosci117: 226-9, 2008. 4-Sarikcioglu L, Demirel BM, Demir N, Yildirim FB, Demirtop A, Oguz N:Morphological and ultrastructural analysis of the watershed zones after stripping of the vasa nervorum.Int j Neurosci118: 1145-55, 2008 . 5-Yildirim FB, Sarikcioglu L, Ozsoy U, Demir N, Demirtop A, Ucar Y:Effect of FK506 administration after obturator nerve injury: a functional and ultrastructural study.Acta Neurobiol Exp 68: 477-483, 2008. 6-Coskun N, Yavuz A, Dikici MB, Sindel T, Islamoglu K, Sindel M: Three-dimensional measurements of the nasal interdomal fat pad. Aesthetic Plast. Surg32:262-5,2008 7-Coskun N, Yuksel M, Cevener M, Arican RY, Ozdemir H, Bircan O, Sindel T, Ilgi S, Sindel M:Incidence of accessory ossicles and sesamoid bones in the feet: a radiographic study of the Turkish subjects. Surg Radiol Anat-2008 8-Ozsoy U, Mutluay R, Oygur N, Akbas H, Sindel S, Sindel M:Effect of denervation and ischemia reperfusion injury on serum nitric oxide levels in rats. Saudi Med J. 29:1561-6.2008 ŀ International Journal of Neuroscience, 118:1145–1155, 2008 Copyright C 2008 Informa Healthcare USA, Inc. ISSN: 0020-7454 / 1543-5245 online DOI: 10.1080/00207450801898220 MORPHOLOGICAL AND ULTRASTRUCTURAL ANALYSIS OF THE WATERSHED ZONES AFTER STRIPPING OF THE VASA NERVORUM LEVENT SARIKCIOGLU BAHADIR MURAT DEMIREL Akdeniz University Faculty of Medicine, Department of Anatomy Antalya, Turkey NECDET DEMIR Akdeniz University Faculty of Medicine, Department of Histology and Embryology Antalya, Turkey For personal use only. FATOS B. YILDIRIM Akdeniz University Faculty of Medicine, Department of Anatomy Antalya, Turkey ARIFE DEMIRTOP Akdeniz University Int J Neurosci Downloaded from informahealthcare.com by Akdeniz Universitesi on 10/03/10 Faculty of Medicine, Electron Microscopy Unit (TEMGA) Antalya, Turkey Received 3 November 2006. The present study was supported by Akdeniz University Research Fund (project no: 2005.01.0103.010). The authors thank Mr. Oktay Kuru for his constrictive comments and help with this manuscript. Address correspondence to Levent Sarikcioglu, Ph.D., Department of Anatomy, Akdeniz University Faculty of Medicine, 07070 Antalya, Turkey. E-mail: [email protected], [email protected] 1145 Research paper Acta Neurobiol Exp 2008, 68: 477–483 Effect of FK506 administration after obturator nerve injury: A functional and ultrastructural study Fatos B. Yildirim1, Levent Sarikcioglu1*, Umut Ozsoy1, Necdet Demir2,3, Arife Demirtop3*, and Yasar Ucar1 1Department of Anatomy, Akdeniz University Faculty of Medicine, Antalya, Turkey, *Email: [email protected]; 2Department of Histology and Embryology, Akdeniz University Faculty of Medicine, Antalya, Turkey; 3Electron Microscopy Unit (TEMGA), Akdeniz University Faculty of Medicine, Antalya, Turkey The frequency of obturator nerve damage due to pelvic diseases, fractures or gynecologic procedures is uncertain. In the present study, we investigated the effect of FK506, a potent macrolide antibiotic and immunosuppresant, on obturator nerve recovery at morphological and functional levels. Forty female Wistar rats were randomly divided into four groups (control, sham, FK506-treated, vehicle-treated). In half of animals (FK506-treated and vehicle-treated) an obturator nerve crush (30 seconds clamp) was created. In FK506-treated group FK506 administration (1 mg/kg/day, subcutaneously) was performed on each postoperative day. All the rats were functionally evaluated by pinch and adduction tests preoperatively and postoperatively at one, two, three and four weeks after nerve injury. On the 28th postoperative day obturator nerve samples were collected and analyzed qualitatively by light and electron microscopy. FK506 treatment resulted in dramatic improvement in nerve function and in the ultrastructure of nerve fibers suggesting its therapeutic potential in traumatic obturator nerve injury. Key words: FK506, obturator nerve, injury, functional recovery INTRODUCTION a synovial cyst (Bischoff and Schonle 1991, Sorenson et al. 2002, Stuplich et al. 2005, Holub 2006). Gynecologic patients undergoing open lymph- A novel immunosuppressant FK506, a macrolide adenectomy or extensive retroperitoneal surgery antibiotic derived from the soil fungus Streptomyces along the pelvic wall are at increased risk of obtura- tsukubaensis, is about 100 times more potent than tor nerve injury. Obturator nerve injury-related Cyclosporin A (Horton 1991) and its toxicity in symptoms can be motor or sensory, including vari- humans is reported to be less than that associated able gait disturbance, constant pain or anesthesia with Cyclosporin A (Wang et al. 1997, Wang and along the nerve distribution (Cardosi et al. 2002, Gold 1999). FK506 is used clinically for the preven- Sorenson et al. 2002). The causes and mechanisms tion of allograft rejection. Its immunosuppressive of obturator neuropathy are multiple: iatrogenic effect is understood to occur through modulation of (Spaliviero et al. 2004), traumatic (especially after calcineurin activity together with FK506 binding traffic accidents), compression due to psoas muscle protein, FKBP-12. In addition to its ability to sup- hematoma, inguinal hernias, arterial aneurysms, or press immune system cells (T-cell activity), it has a number of non-immune effects (Heitman et al. Correspondence should be addressed to L. Sarikcioglu, 1993, Lyons et al. 1994, Gold et al. 1995, Drake et Email: [email protected] al. 1996). FK506 has been shown to accelerate the Received 16 January 2008, accepted 05 November 2008 rate of nerve regeneration and to promote neurite © 2008 by Polish Neuroscience Society - PTBUN, Nencki Institute of Experimental Biology Aesth Plast Surg (2008) 32:262–265 DOI 10.1007/s00266-007-9038-1 ORIGINAL ARTICLE Three-Dimensional Measurements of the Nasal Interdomal Fat Pad Nigar Coskun Æ Alparslan Yavuz Æ Mustafa B. Dikici Æ Timur Sindel Æ Kemal Islamoglu Æ Muzaffer Sindel Published online: 18 October 2007 Ó Springer Science+Business Media, LLC 2007 Abstract The interdomal fat pad (IFP) is an important Rhinoplasty is one of the most commonly performed structure related to tip deformity in rhinoplasty. This study operations in plastic and reconstructive surgery. Nasal tip aimed to evaluate the IFP by ultrasonography before sur- surgery is an important part of rhinoplasty. Correction of a gery, and to demonstrate the existence of the IFP as a bulbous nose deformity still is a challenging problem in distinct anatomic structure in cadavers and patients. Three cosmetic surgery. Some of the last studies in the literature dimensions of the IFP were measured in 23 patients using are about nasal tip anatomy, and these studies explain the ultrasound before rhinoplasty and in 10 cadavers using surgical difficulties encountered in this anatomic region [1, dissection. All fat pads were examined by histopathologic 3, 7, 9, 11]. methods. In the cadavers, three dimensions of the IFP were The nasal tip consists of skin, subcutaneous tissue, the found: 2.3 · 3.7 · 12.8 mm. In the patients, three dimen- superficial musculo-aponeurotic system, ligaments, and sions of IFP were measured by ultrasonography: lower lateral cartilages [5]. The thickest fat layer of the 2.8 · 4.1 · 13.7 mm. Histopathologic examinations nose is in the supratip area. Soft tissue thickness over the showed that the IFP is a structure differentiated from tip of the nose shows individual variety among patients. subcutaneous tissue. The IFP was demonstrated in all The interdomal fat pad (IFP) is a tissue that occupies the cadavers and patients by surgical and radiologic methods. interdomal space [12]. In their study, plastic surgeons have All cases had a fat pad in the interdomal space with varying emphasized the importance of the IFP in rhinoplasty [6]. sizes. The purpose of our study was to evaluate the nasal tip site using ultrasonography (USG), and to demonstrate the Keywords Bulbous nose Á Fat pad Á Interdomal
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