20 Glorious Years of Service

th Y

R 20 A S R E A N NI V Head Office: Factory: Marketing: Gaindakot Municipality 04, Gaindakot Municipality 10, Bakhundole 03, Lalitpur, Nepal Nawalparasi, Lumbini Nawalparasi, Lumbini (Opposite to Embassy of the Democratic (3 km West from Pulchowk, Narayangarh) Ph.: 977-78-402004 People's Republic of Korea) Ph.: 977-78-502004 E-mail: [email protected] Ph.: 01-5526905 E-mail: [email protected] E-mail: [email protected] Inspired by Excellence Website: www.timepharma.com Company Broucher Message from Chairman & Managing Director

Health is the most invaluable asset and access to quality health services is most deserving rights to every human being. Pharmaceutical services are one of the important parts in health services and in Nepal the pharmaceutical infrastructure G. Narayan Bahadur Chhetri is on the developmental phase. Time Pharmaceuticals was founded 20 years ago with a vision to support the national health delivery and pharma insufficiency. Since our establishment we have been continuously evolving and upgrading our company's manufacturing facilities, structure and processes in response to the changes that is taking place in the Pharmaceutical sector globally.

In coming years too we will be more committed and imaginative in building our Industry as a new business model, take required initiatives for creating better business values and morals to contribute the society. We have the responsibility to support the community we live and work in. We commit in achieving these responsibilities while delivering better earnings to stake holders and the employees.

I would like to thank everyone who has been directly or indirectly involved in supporting our efforts to make TIME Pharmaceuticals a name synonymous for quality and trust. It is due to untiring efforts of all Timeans, that we have achieved many valuable milestones in the past. Thank you all once again and I ask for your enduring support as we need to address many challenges ahead in building TIME Pharma and also our pharmaceutical infrastructure in the country. Message from Deputy Managing Director

20 years is a milestone. This commercial success which we achieved is due to the patronage of our valued customers, trustworthy partners , along with our dedicated team. We believe in progress brought about by hard work and ethical practice. I believe with this principal we will strive to achieve much bigger market share in future with emphasis on Research & Development through technical collaboration with MNC. Sudarshan Lal Shrestha

Message from Factory Operation Director

Our goal is to improve health care system of the country by developing and delivering advanced pharmaceutical products.We believe that TIME Pharmaceutical’s ability to adapt to new changes will provide a true indication of its growth and sustainability in the market place.

Ashesh Bhandary Message from Finance Director

Profit maximization is the key objective to satisfy the core business expectations. We do believe that optimal capital structure and operational efficiency leads to corporate competitiveness in the dynamic business environment that has added the need of adequate strategic R & D investment for exploiting the business opportunities in the long run." Manoj Pradhan Technical Collaboration with Multi-National Company ‘:j:y g]kfn xfd|f] cleofg,

u'0f:t/Lo cf}iflw xfd|f] klxrfg’ 2072

Established separate Introduction of COS MO Expansion of separate Introduction of N EXUS Cephalosporin block with Division with focus on manufacturing facility of Division with focus on ultra modern Dermatology, E NT, Sterile Products esp. E /E Orthopedic, Neurolog y, manufacturing facility Gynaecology & Urology Drops Gastroenterology & Dental therapeutic segments therapeutic segments

2072 2070 2067 2066

Certified with WHO:GMP, Expansion of facility- Oral Modernization of Launching of speciality ISO 9001 & I SO 14001 Liquid Production Infrastructures with division GENESIS with focus separate P enicillin Block on Cardiology, Diabetology/ Endocrionology & Psychiatric therapeutic segments

2065 2064 2063 2063

Expansion of product Expansion of facility- Expansion of product Commercial Operation range- Cephalosporin Ointment Production range- Penicillin Products Started Products

2059 2056 2054 2054 Corporate Office

ABOUT US MISSION AND VISION With the vision to provide sustainable solution to the health care challenges To enrich the fellow citizens by providing quality products and services at affordable price beside exceed customer's expectation at all times with a and support nation's self sufficiency in medicine, TIME Pharmaceuticals was commitment to consistent quality, innovation, career growth to its employees established in October 1995 and it commenced its commercial production and sustained returns to its investors. and marketing in November 1997. Today, with a leading portfolio of quality products TIME Pharmaceuticals is able to gain widespread recognition and OUR CORE VALUES establish itself as one of the leading Pharmaceutical Company in Nepal, Dedication to Quality and Excellence catering more than 180 products of major therapeutic segments. Stable Manufacturing and Sustained Supply Chain TIME is committed to deliver the best of health care services to every individual for a healthier life which has constantly inspired our people to innovate, excel Human Safety Management System and set our own new standards. With the mission "Inspired by Excellence" Internal and External Customer Satisfaction and bringing together the disciplines of WHO-GMP, ISO 9001:2008 and ISO 14001:2004, our world-class manufacturing unit produces therapeutic products portfolio that matches international class and offers the best services which is required in the better health care delivery system. We are focused towards extending our product portfolio, improving the existing products as well as drug delivery systems and expanding product applications with an appropriate update of latest technologies and upgrading facilities by technical collaboration with the MNC. Factory Celebrating 20 YEARS of Excellence

MANAGEMENT requirements are represented through quality raw materials, quality packing The entire operations are fully managed by the dynamic working team of materials, quality process and quality test methods which are resourced by four; headed by Chairman and Managing Director. The Marketing Department specifications, validated process and methods. is headed by Deputy Managing Director, Corporate office is headed by Finance Director and the Plant is headed by Factory Operation Director. All the The WHO cGMP, ISO and ICH guidelines are being adopted as the basis for operations are professionally managed by the dedicated department under establishing quality system in inventory management, production and the the leadership of qualified heads and highly enthusiastic and motivated quality control activities. The use of these guidelines has been able to facilitate staff's. cooperation within the different functional departments to exchange the information's and experience and harmonization of standards and procedures. MANUFACTURING UNIT Our 35,000 sq. ft. plus ultra modern state of art manufacturing plant is located in Gaidakot-10, Nawalparasi, 12 Km west from Narayanghat. The plant facility and the production process are with compliance of WHO-GMP standard to achieve highest quality product that satisfies the need of the customer. Our plant has successfully integrated multi technology capability to manufacture various types of dosage forms including Capsules/EE Drops/Delayed /Extended/Immediate Release Tablets/Dry Syrup, Creams/Ointments etc. Highly skilled and motivated human resource drives the company with strong passion to build up as one of the leading Pharmaceutical Industry in Nepal.

QUALITY ASSURANCE TIME Pharmaceuticals applies quality assurance system to organize its activities in such a way that technical, administrative and human factors are well managed and controlled to enhance the quality of its products. All the control activities are oriented towards the reduction, elimination and prevention of probable quality deficiencies. Quality control in TIME Pharma is well defined set of specifications and followed through operations to demonstrate assured quality. The quality which is intended to be offered to customer is achieved through quality by design(QbD). The translation of the customer’s SALES & MARKETING TIME Pharma has been enjoying its excellent presence in the Nepali a strong sales force which makes up a strong distribution network that covers pharmaceutical market since 19 years. Our products are well accepted by almost every parts of the country. Our Sales team is divided into four major the Nepalese medical professionals and the consistent growth of the company divisions: TIME, GENESIS, NEXUS & COSMO. Each division is structured with was only possible through its dedication and commitment towards delivering competent Sales Representative, Area Sales Manager, Regional Sales Managers, sustained and enhanced quality products and services to our customers. We Senior Sales Manager, Assistant Country Sales Manager, Deputy General at TIME always take top priority in meeting and exceeding our customer's Manager etc. All the sales & marketing activities of four major divisions are desire and needs to satisfy them. To accomplish this, company has deployed supported by highly creative Market Planning Department.

CORPORATE SOCIAL RESPONSIBILITY (CSR)

Our policy is to concentrate CSR activities mainly around local Waste Mgmt. Training communities where our facilities, plants & offices are located. Also, our primarily concentration are to uplift the healthcare standards of our local communities. We organize awareness Earthquake Relief Activity program, periodical health camps, and medicine donation program enhancing the lives of the people & also we always strive to be responsive to the degrading environment issues. The air pollution of the country has reached to the worst ever and would remain a big challenge to our future generations. TIME Pharma being a responsible corporate citizen has initiated Plantation Programme awareness programs of the worst air pollutions problems and works for the solutions. We hope & believe that a small approach from our part would make a big difference and help preserve the environment for future generations.

Earthquake Relief Activity

Let our surrounds remain green and euphoric, Let the trees bloom and flourish Let the air we breathe be fresh and pure World Environment Day Let's act today for a better future

Health Camp

"Lend Your Hands as a Solution to Minimize Pollution because Nature PROTECTS if she is PROTECTED" TIME DIVISION

Penicillin Antibiotics Proton Pump Inhibitor/Anti-ulcerant Ampicillin 250 mg + Cloxacillin 250 mg Capsules 19 ULSEF Omeprazole 20 mg Capsules 1 BROCLOX Ampicillin 125 mg + Cloxacillin 125 mg / 5 ml Dry Syrup Beta blocker Cephalosporin Antibiotic 20 I- CARE Timolol Maleate 0.5% w/v Eye Drops 2 DINIR Cefdinir 125 & 250 mg DT Expectorant Cefixime 100 & 200 mg DT Chlorpheniramine Maleate 2 mg + Bromhexine HCl 4 mg + 3 FIXCEF 21 PULMARIN Cefixime 50 mg / 5 ml & 100 mg / 5 ml Dry syrup Pseudoephedrine HCl 30 mg Expectorant Fluoroquinolone Antibiotic Anti-asthmatic 4 CIFROX Ciprofloxacin 500 mg Tablets 22 ASMAREX PLUS Salbutamol 2 mg + Bromhexine 4 mg / 5 ml Syrup 5 CIFROX E/E Ciprofloxacin 0.3% w/v Eye/Ear Drops 23 ASMAREX Salbutamol 2 mg / 5 ml Syrup 6 L-FROX Levofloxacin 500 mg Tablets DMARD 7 OFROX E/E Ofloxacin 0.3% w/v Eye/Ear Drops 24 SULFAZ Sulphasalazine 500 mg Delayed Released Tablets Tetracycline Antibitoc NSAID/Analgesic 8 T-DOX Doxycycline Hyclate 100 mg Capsules Diclofenac 1% w/w + Methyl Salicylate 10% w/w + 25 SALIF Anti-protozoal Linseed Oil 3% w/w Gel Metronidazole 400 mg + Diloxanide furoate 500 mg Tablets Ibuprofen 400 mg + Paracetamol 500 mg Tablets 9 METDIL 26 PARAFLAM Metronidazole 100 mg + Diloxanide furoate 125 mg / 5 ml Suspension Ibuprofen 100 mg + Paracetamol 125 mg / 5 ml Suspension Oxazolidinone Antibiotic Anticold 10 LIZOLID Linezolid 600 mg Tablets Pseudoephedrine 30 mg + Paracetamol 500 mg + Anti-helmintic Chlorpheniramine Maleate 2 mg Tablets 27 SINEX Albendazole 400 mg Tablets Pseudoephedrine 15 mg + Paracetamol 125 mg + 11 WORMSTAT Albendazole 400 mg / 10 ml Suspension Chlorpheniramine Maleate 2 mg / 5 ml Suspension Anti-fungal Anti-histamine 12 FAZOLE Fluconazole 150 mg Capsules Cetirizine HCl 10 mg Tablets 28 T-CET Anti-infective/Anti-inflammatory Cetirizine HCl 5 mg / 5 ml Syrup Beclomethasone 0.025% w/w + Clotrimazole 1% w/w + Supplement 13 BECLOTIME Gentamicin Sulphate 0.1%w/w Cream 29 BECOMIN Vitamin B Complex Syrup NSAID 14 KEROL Ketorolac 0.4% w/v Ophthalmic Solution 15 KEROL-E Ketorolac 0.5% w/v Ophthalmic Solution Antipyretic/Analgesic Paracetamol 500 mg Tablets 16 TIMOL Paracetamol 125 mg / 5 ml Syrup Antiseptic/Disinfectant 17 BETATIME Povidone Iodine 5% w/w Ointment Topical Anti-infective 18 GENTIME Gentamicin Sulphate 0.2% w/w Cream Team TIME GENESIS DIVISION

Anti-diabetic Anti-parkinson 1 ACBOZ Acarbose 25 & 50 mg Tablets 21 PARKDYL Benzhexol 2 mg Tablets 2 OBICHEK Metformin 500 & 850 mg Tablets Anti-epileptic Metformin 500 + Glimipiride 1 mg Tablets 22 CZEPIN Carbamazepine 100 & 200 mg Tablets 3 OBICHEK G1/2 Metformin 500 + Glimipiride 2 mg Tablets Anti-depressant 4 OBICHEK-SR Metformin 500 & 1000 mg Sustained Release Tablets 23 ECT Escitalopram 5 & 10 mg Tablets Metformin 500 + Sitagliptin 50 mg Tablets 24 XECTIN Fluoxetine 10 & 20 mg Capsules 5 SITA-M Metformin 850 + Sitagliptin 50 mg Tablets Anti-anxiety Metformin 1000 + Sitagliptin 50 mg Tablets 25 ZOLAP Alprazolam 0.25 & 0.50 mg Tablets 6 GLIPID Glimipiride 1, 2, 3 & 4 mg Tablets Antihypertensive 7 BETALOL Atenolol 25 &50 mg Tablets 8 HYPERNOL Propanolol 10, 20 & 40 mg Tablets 9 E-PRIL Enalapril 2.5 & 5 mg Tablets 10 LODIP Amlodipine 2.5 & 5 mg Tablets 11 T-CARDIS Telmisartan 20 & 40 mg Tablets 12 SART Losartan 25 & 50 mg Tablets Losartan Potassium 25 mg + 13 SART-H Hydrochlorothiazide 12.5 mg Tablets Diuretics 14 HYSIS Hydrochlorothiazide 12.5 & 25 mg Tablets 15 FRUTONE Spironolactone 50 mg + Frusemide 20 mg Tablets 16 SEMID Frusemide 40 mg Tablets Anti- anginal 17 TRINE Trimetazidine 20 mg Tablets Hypolipidaemic Team GENESIS 18 LIPLOW Atorvastatin 5, 10 & 20 mg Tablets Anti-oxidant 19 KYUTEN Co-enzyme Q10 100 mg Capsules Anti-psychotic 20 HALODOL Haloperidol 0.25 & 1.5 mg Tablets NEXUS DIVISION

Penicillin Antibiotics Anti-convulsant Amoxicillin Trihydrate 250 mg + 15 PRE-Z Pregabalin 75 & 150 mg Capsules 1 HICLOX Cloxacillin Sodium 250 mg Capsules Proton Pump Inhibitor Amoxicillin Trihydrate 250 & 500 mg Capsules 16 RABEPRA Rabeprazole Sodium 20 mg Capsules 2 HIMOX Amoxicillin Trihydrate 100 mg / 1 ml Drops Anti-spasmodic/Anticholinergic Amoxicillin Trihydrate 125 mg / 5 ml Dry Syrup 17 SPASMID Dicyclomine Hydrochloride 20 mg Tablets Fluoroquinolone Antibiotics Opioid Analgesic Ofloxacin 200 & 400 mg Tablets 18 TRAMA Tramadol Hydrochloride 50 mg Capsules 3 OFROX Ofloxacin 50 mg / 5 ml Suspension Muscle Relaxant Cephalosporin Antibiotics 19 ZANID Tizanidine Hydrochloride 2 mg Tablets Cephalexin 500 mg Capsules, 100 mg / 1 ml Drops 4 LEXIN Cephalexin 125 mg / 5 ml Dry Syrup Macrolide Antibiotics 5 CLARITH Clarithromycin 500 mg Tablets NSAID 6 ANTIFLA Aceclofenac 100 mg Tablets 7 INTIME Indomethacin 25 mg Capsules Anti-histamine 8 EG Ebastine 10 & 20 mg Tablets Digestive Enzyme 9 FESOZYME Pepsin 10 mg + Fungal Diastase 50 mg Capsules Supplement 10 MECON Mecobalamin 1500 & 500 mcg Tablets Anti-protozoal Metronidazole 400 mg Tablets 11 MET Metronidazole 200 mg / 5 ml Suspension Team NEXUS Anti-emetic 12 NAUSINORM Metoclopramide Hydrocholoride 10 mg Tablets 13 VOMISET Ondansetron Hydrochloride 4 & 8 mg Tablets 14 PARAZINE Prochlorparazine Maleate 5 mg Tablets COSMO DIVISION

Penicillin Antibiotics Anti-fungal 1 TICLOX Cloxacillin 500 mg Capsules Terbinafine 250 mg Tablets 13 NAFIN Cephalosporin Antibiotics Terbinafine 1% w/w Cream Cefadroxil 250 mg DT 14 ITRATIME Itraconazole 100 mg Capsules 2 FEDROX Cefadroxil 500 mg Capsules 15 CLOTIME Clotrimazole 1% w/w Cream Cefadroxil 125 mg / 5 ml Dry Syrup Nasal decongesant Macrolide Antibiotics 16 T-ZOLINE A Oxymetazoline 0.05% w/v Nasal Drops Azithromycin 250 & 500 mg Tablets 17 T-ZOLINE P Oxymetazoline 0.025% w/v Nasal Drops 3 AZT Azithromycin 100 mg / 5 ml & 200 mg / 5 ml Suspension Normal Saline Alpha Blocker 18 T-ZOLINE S Sodium Chloride 0.65% Nasal Solution 4 FUZON Alfuzosin Hydrochloride 10 mg Extended Release Tablets Supplement Anti-histamine 19 BECOMIN Vitamin B Complex + Vitamin C Capsules Fexofenadine HCl 120 mg, 180 mg Tablets 20 POLYMAX Iron III Polymaltose 100 mg & Folic Acid 1 mg Tablets 5 NOLAR Fexofenadine HCl 30 mg / 5 ml Suspension 21 FOLVIN Folic Acid 5 mg Tablets Anti-fibrinolytic 6 TRANCAP Tranexamic acid 250 & 500 mg Capsules Anticold Chlorpheniramine maleate 4 mg + Pseudoephedrine 60 mg Tablets 7 SUDOFEN Chlorpheniramine maleate 2 mg + Pseudoephedrine 30 mg Syrup Topical Antibiotics 8 ROCIN Mupirocin 2% Ointment Anti-infectives Chloramphenicol 5% w/v + 9 CHLORAM L Lidocaine 2% w/v Ear Drops Clotrimazole 1% w/v + Lidocaine 2% w/v + 10 CLOTIME LC Chloramphenicol 5% w/v Ear Drops 11 CLOTIME L Clotrimazole 1% w/v + Lidocaine 2% w/v Ear Drops Topical Corticosteroid Team COSMO 12 CLOBSOL Clobetasol Propionate 0.05% w/w Cream 20 Glorious Years of Service

th Y

R 20 A S R E A N NI V Head Office: Factory: Marketing: Gaindakot Municipality 04, Gaindakot Municipality 10, Bakhundole 03, Lalitpur, Nepal Nawalparasi, Lumbini Nawalparasi, Lumbini (Opposite to Embassy of the Democratic (3 km West from Pulchowk, Narayangarh) Ph.: 977-78-402004 People's Republic of Korea) Ph.: 977-78-502004 E-mail: [email protected] Ph.: 01-5526905 E-mail: [email protected] E-mail: [email protected] Inspired by Excellence Website: www.timepharma.com Company Broucher