Leukotriene 4, Urine

Lab Dept: Urine/Stool Test Name: LEUKOTRIENE E4, URINE General Information Lab Order Codes: LTE4 Synonyms: Cysteinyl Leukotriene , Mastocytosis, Systemic Mast Cell, Activation Mast Cell Activation, Syndrome LTE4 CPT Codes: 82542 – Column chromatography, non drug analytes, NOS, qualitative or quantitative, each specimen Test Includes: Leukotriene E4 and Creatinine, Urine. Creatinine is performed at no additional charge. Logistics Test Indications: Useful in evaluating patients with systemic mastocytosis, asthma and respiratory diseases. Lab Testing Sections: Urine/Stool - Sendouts Referred to: Mayo Medical Laboratories (MML code: LTE4) Phone Numbers: MIN Lab: 612-813-6280 STP Lab: 651-220-6550 Test Availability: Daily, 24 hours Turnaround Time: 2 – 6 days, performed Tuesday and Friday Special Instructions: See Patient Preparation Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens Specimen Specimen Type: Urine, random or 24 hour collection (no preservative) Container: Plastic 5 mL urine tube or Mayo transport tube with no preservatives, Supply T465 Draw Volume: 4 (min: 1 mL) urine Processed Volume: Same as Draw Volume Collection: Routine random or 24 hour urine collection Special Processing: Lab Staff: Send 4 (min: 1 mL) 24 hour or Random Urine Mayo transport tube (Mayo Supply: T465) with no preservatives. Store and Ship specimen at refrigerated temperatures. Forward promptly. Specimen is stable for 7 days refrigerated. Patient Preparation: Discontinue taking 5- Lipoxygenase inhibitor Zileuton/Zyflo at least 48 hours prior testing. Sample Rejection: Mislabeled or unlabeled specimens Interpretive Reference Range: All ages: < or = 104 pg/mg creatinine Critical Values: N/A Limitations: Systemic mastocytosis is a herterogeneous disease and lack of elevated LTE4 does not exclude the diagnosis of Mast cell disease. Increased excretion of LTE4 has also been reported in the following conditions: asthma, eosinophilic pneumonia, respiratory syncytial virus infection, atopic dermatitis, Crohn’s disease, and rheumatoid arthritis. This assay measures both LTE4 and 11-trans-LTE4 as markers of mast cell disease. Methodology: LTE4:Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Creatinine: Enzymatic Colorimetric Assay References: Mayo Medical Laboratories July 2018 .

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Montelukast, a Leukotriene Receptor Antagonist, Reduces the Concentration of Leukotrienes in the Respiratory Tract of Children with Persistent Asthma
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