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ANNUAL REVIEW 1 October 2005–30 September
WELLCOME TRUST ANNUAL REVIEW 1 October 2005–30 September 2006 ANNUAL REVIEW 2006 The Wellcome Trust is the largest charity in the UK and the second largest medical research charity in the world. It funds innovative biomedical research, in the UK and internationally, spending around £500 million each year to support the brightest scientists with the best ideas. The Wellcome Trust supports public debate about biomedical research and its impact on health and wellbeing. www.wellcome.ac.uk THE WELLCOME TRUST The Wellcome Trust is the largest charity in the UK and the second largest medical research charity in the world. 123 CONTENTS BOARD OF GOVERNORS 2 Director’s statement William Castell 4 Advancing knowledge Chairman 16 Using knowledge Martin Bobrow Deputy Chairman 24 Engaging society Adrian Bird 30 Developing people Leszek Borysiewicz 36 Facilitating research Patricia Hodgson 40 Developing our organisation Richard Hynes 41 Wellcome Trust 2005/06 Ronald Plasterk 42 Financial summary 2005/06 Alastair Ross Goobey 44 Funding developments 2005/06 Peter Smith 46 Streams funding 2005/06 Jean Thomas 48 Technology Transfer Edward Walker-Arnott 49 Wellcome Trust Genome Campus As at January 2007 50 Public Engagement 51 Library and information resources 52 Advisory committees Images 1 Surface of the gut. 3 Zebrafish. 5 Cells in a developing This Annual Review covers the 2 Young children in 4 A scene from Y fruit fly. Wellcome Trust’s financial year, from Kenya. Touring’s Every Breath. 6 Data management at the Sanger Institute. 1 October 2005 to 30 September 2006. CONTENTS 1 45 6 EXECUTIVE BOARD MAKING A DIFFERENCE Developing people: To foster a Mark Walport The Wellcome Trust’s mission is research community and individual Director to foster and promote research with researchers who can contribute to the advancement and use of knowledge Ted Bianco the aim of improving human and Director of Technology Transfer animal health. -
CRISPR and Beyond Perturbations at Scale to Understand Genomes 2-4
CRISPR and Beyond Perturbations at Scale to Understand Genomes 2-4 September 2019 Wellcome Genome Campus, UK Lectures to be held in the Francis Crick Auditorium Lunch and dinner to be held in the Hall Restaurant Poster sessions to be held in the Conference Centre Spoken presentations - If you are an invited speaker, or your abstract has been selected for a spoken presentation, please give an electronic version of your talk to the AV technician. Poster presentations – If your abstract has been selected for a poster, please display this in the Conference Centre on arrival. Conference programme Monday, 2 September 2019 11:45-12:50 Registration 12:50-13:00 Welcome and introductions Leopold Parts, Wellcome Sanger Institute UK 13.00-14.00 Keynote lecture Allan Bradley Kymab, UK 14:00-15:30 Session 1: Understanding impact of coding variations Chair: Leopold Parts, Wellcome Sanger Institute UK 14:00 New approaches for addressing the effect of genetic variation at scale Douglas Fowler University of Washington, USA 14:30 Tools for systematic proactive functional testing of human missense variants Frederick Roth University of Toronto 15:00 The mutational landscape of a prion-like domain Benedetta Bolognesi Institute for Bioengineering of Catalonia, Spain 15:15 Functional determination of all possible disease-associated variants in a region of CARD11 using saturation genome editing Richard James University of Washington, USA 15:30-16:00 Afternoon tea 16:00-17:30 Session 2: Measuring consequences of non-coding variation Chair: Lea Starita, University -
Strategic Plan 2011-2016
Strategic Plan 2011-2016 Wellcome Trust Sanger Institute Strategic Plan 2011-2016 Mission The Wellcome Trust Sanger Institute uses genome sequences to advance understanding of the biology of humans and pathogens in order to improve human health. -i- Wellcome Trust Sanger Institute Strategic Plan 2011-2016 - ii - Wellcome Trust Sanger Institute Strategic Plan 2011-2016 CONTENTS Foreword ....................................................................................................................................1 Overview .....................................................................................................................................2 1. History and philosophy ............................................................................................................ 5 2. Organisation of the science ..................................................................................................... 5 3. Developments in the scientific portfolio ................................................................................... 7 4. Summary of the Scientific Programmes 2011 – 2016 .............................................................. 8 4.1 Cancer Genetics and Genomics ................................................................................ 8 4.2 Human Genetics ...................................................................................................... 10 4.3 Pathogen Variation .................................................................................................. 13 4.4 Malaria -
158273472.Pdf
ANNUAL .2003REPCOLD SPRING HARBOR LABORATORY .1; ANNUAL REPORT 2003 © 2004 by Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory One Bungtown Road Cold Spring Harbor, New York 11724 Web Site: www.cshl.edu Managing Editors Jeff Picarello, Lisa Becker Production Editor Rena Steuer Copy Editor Dorothy Brown Development Manager Jan Argentine Project Coordinators Maria Falasca, Nora Rice Production Manager Denise Weiss Desktop Editor Susan Schaefer Nonscientific Photography Miriam Chua, Bill Geddes Cover Designer Denise Weiss Book Designer Emily Harste Front cover: McClintock Laboratory (right) and Carnegie Library (left) (photos by Miriam Chua) Back cover: Magnolia Kobus on grounds of Cold Spring Harbor Laboratory (photo by Bruce Stillman) Section title pages: Miriam Chua Contents Officers of the Corporation/Board of Trusteesiv-v Governancevi Committees vii Edwin Marks (1926-2003) viii PRESIDENT'S REPORT Highlights5 CHIEF OPERATING OFFICER'S REPORT 25 50TH ANNIVERSARY OF THE DOUBLE HELIX 29 RESEARCH 47 Cancer: Gene Expression 49 Cancer: Genetics 74 Cancer: Cell Biology 106 Bioinformatics and Genomics 134 Neuroscience152 Plant Development and Genetics 199 CSHL Fellows 212 Author Index 217 WATSON SCHOOL OF BIOLOGICAL SCIENCES 219 Dean's Report 221 Courses 238 Undergraduate Research Program245 Partners for the Future 248 Nature Study 249 COLD SPRING HARBOR LABORATORY MEETINGS AND COURSES 251 Academic Affairs253 Symposium on Quantitative Biology 255 Meetings 258 Postgraduate Courses295 Seminars 353 BANBURY CENTER 355 Director's Report357 Meetings 365 DOLAN DNA LEARNING CENTER 403 Director's Report 405 Workshops, Meetings, and Collaborations 418 COLD SPRING HARBOR LABORATORY PRESS 425 Publications 426 Executive Director's Report 427 FINANCE 431 History of the CSHL Endowment 433 Financial Statements 444 Financial Support448 Grants448 Institutional Advancement 457 Capital and Program Contributions 458 Watson School of Biological Sciences Capital Campaign 459 Annual Contributions 460 LABORATORY STAFF 474 III Officers of the Corporation William R. -
Human Genetics 1990–2009
Portfolio Review Human Genetics 1990–2009 June 2010 Acknowledgements The Wellcome Trust would like to thank the many people who generously gave up their time to participate in this review. The project was led by Liz Allen, Michael Dunn and Claire Vaughan. Key input and support was provided by Dave Carr, Kevin Dolby, Audrey Duncanson, Katherine Littler, Suzi Morris, Annie Sanderson and Jo Scott (landscaping analysis), and Lois Reynolds and Tilli Tansey (Wellcome Trust Expert Group). We also would like to thank David Lynn for his ongoing support to the review. The views expressed in this report are those of the Wellcome Trust project team – drawing on the evidence compiled during the review. We are indebted to the independent Expert Group, who were pivotal in providing the assessments of the Wellcome Trust’s role in supporting human genetics and have informed ‘our’ speculations for the future. Finally, we would like to thank Professor Francis Collins, who provided valuable input to the development of the timelines. The Wellcome Trust is a charity registered in England and Wales, no. 210183. Contents Acknowledgements 2 Overview and key findings 4 Landmarks in human genetics 6 1. Introduction and background 8 2. Human genetics research: the global research landscape 9 2.1 Human genetics publication output: 1989–2008 10 3. Looking back: the Wellcome Trust and human genetics 14 3.1 Building research capacity and infrastructure 14 3.1.1 Wellcome Trust Sanger Institute (WTSI) 15 3.1.2 Wellcome Trust Centre for Human Genetics 15 3.1.3 Collaborations, consortia and partnerships 16 3.1.4 Research resources and data 16 3.2 Advancing knowledge and making discoveries 17 3.3 Advancing knowledge and making discoveries: within the field of human genetics 18 3.4 Advancing knowledge and making discoveries: beyond the field of human genetics – ‘ripple’ effects 19 Case studies 22 4. -
The Changing Governance of Genetic Intervention Technologies
The Changing Governance of Genetic Intervention Technologies An Analysis of Legal Change Patterns, Drivers, Impacts, and a Proposed Reform Neil Harrel Thesis submitted to the University of Ottawa in partial fulfillment of the requirements for the Doctorate in Philosophy (Ph.D.) degree in Law Faculty of Law University of Ottawa © Neil Harrel, Ottawa, Canada, 2021 . Abstract Major breakthroughs in biotechnology are leading to the emergence of novel methods to select and alter future individuals’ genomes. Genetic intervention technology is evolving from the medical practice of screening for life-threatening congenital malformations to the selection against embryos that might develop mild disabilities. Scientific research suggests that heritable genome-editing technology would enable the custom alteration and the enhancement of human biological characteristics, including appearance, athletic and intellectual abilities. These novel developments and their potential long-term impacts raise the question of how effective are the laws on genetic interventions in setting limits to rapidly evolving biotechnologies. This thesis examines genetic intervention laws in the United Kingdom and France and shows it exhibits a pattern of continuous legal changes over the past several years to permit a broadening range of genetic interventions that were previously prohibited. This pattern is characterized by the regulatory licensing of genetic interventions that specific legal restrictions have sought to disallow, such as screening against conditions that are mild, treatable and not predominantly determined by genes. Moreover, governments are currently considering replacing their bans on inheritable human genetic modification with regulations that will allow the alteration of genes linked to conditions deemed “serious” and for “therapeutic” purposes. This proposed regulatory model would enable licensing the very same type of genomic alterations intended to be prohibited – genetic enhancements of human physiological and cognitive capabilities. -
Wellcome Trust Annual Report and Financial Statements 2009
ANNUAL REPORT AND FINANCIAL STATEMENTS 2009 A charity registered in England, no. 210183. 1 TABLE OF CONTENTS Page Chairman’s Statement 2 Trustee’s Report 4 Objects, Mission and Aims 4 Financial Summary 5 Review of Past and Future Activities 7 Investment Summary 10 Remuneration Report 19 Structure, Governance and Policy 21 Independent Auditors’ Report 28 Consolidated Statement of Financial Activities 29 Consolidated Balance Sheet 30 Statement of Financial Activities of the Trust 31 Balance Sheet of the Trust 32 Consolidated Cash Flow Statement 33 Notes to the Financial Statements 34 Reference and Administrative Details 73 2 CHAIRMAN’S STATEMENT In February 2009 I had the great privilege of spending majority of those attending the continuing professional time with colleagues at our Major Overseas Programme in development courses at the Centre have indicated Vietnam. Based in the Hospital for Tropical Diseases, Ho the experience had a significant positive impact on Chi Minh City, researchers are improving our understanding themselves, their school or their pupils, and many say of many of the world’s deadliest diseases, including malaria, they have developed new skills in teaching methods. dengue, typhoid, tetanus and tuberculosis. It is a sobering experience to witness first hand the debilitating effects of Expenditure and investments diseases that we do not see in our day to day lives. In the clinical wards we visited, the important and integral role that The many exciting projects outlined in our Trustee’s research plays in improving patient care and quality of life Report would not be possible without the privilege of for so many individuals and their families is abundantly clear. -
Paterson Institute for Cancer Research SCIENTIFIC REPORT 2006 Leukapheresis Blood Product Is Depleted of CD25 + Lymphocytes Prior to Infusion Back Into the Patient
Paterson Institute for Cancer Research SCIENTIFIC REPORT 2006 Leukapheresis blood product is depleted of CD25 + lymphocytes prior to infusion back into the patient. CD4 +CD25 + regulatory T-cells are thought to be instrumental in allowing a growing cancer to evade immunological attack and the rationale behind this clinical trial is that their removal may unmask an anti-tumour immune response in patients with cancer (See Biological Immune and Gene Therapy Group report on page 36) . Illustration Credits Many illustrations in this report were taken by Jenny Varley and Paul Cliff Cancer Research UK Paterson Institute for Cancer Research SCIENTIFIC REPORT 2006 Cancer Research UK Paterson Institute for Cancer Research Scientific Report 2006 Edited by Professor Jenny Varley, Assistant Director (Research) Design & Layout by Mark Wadsworth (Web & Graphic Designer) Paterson Institute for Cancer Research Wilmslow Road, Manchester M20 4BX Tel: 0161 446 3156 http://www.paterson.man.ac.uk ISSN 1740-4525 Copyright © 2006 Cancer Research UK Printed by Paramount Print Cancer Research UK Registered Charity No. 1089464 Registered as a company limited by guarantee in England and Wales No. 4325234 Registered address 61 Lincoln’s Inn Fields, London WC2A 3PX Tel +44 (0) 20 7242 0200 http://www.cancerresearchuk.org Contents Director’s Introduction . 6 The Manchester Cancer Research Centre. 8 The Paterson Institute for Cancer Research Bioinformatics Group ........................................................................ Crispin Miller . 10 Carcinogenesis -
Leading the Way
Leading the way Highlights 2018/19 World-class 02 research and What we do innovation 02 Director’s Introduction that impacts 04 At a Glance people’s lives Through our cutting-edge infrastructure, scientific independence and innovative ideas we engage in long-term exploratory projects that drive forward science Wherever you see this dark blue text or yellow, click to find more information. Read more about our ground-breaking research into Parasites and Microbes Page 26 sanger.ac.uk What we do Our work Our approach Other information 08 Our work 10 Cancer, Ageing and Somatic Mutation 16 Cellular Genetics 20 Human Genetics 26 Parasites and Microbes 34 Tree of Life 40 Our approach 42 Scale 44 Innovation 46 Culture 48 Influence 52 50 Connections Other info 52 Image Credits 53 Institute Information Wellcome Sanger Institute Highlights 2018/19 1 What we do One such project is the UK Biobank Director’s Vanguard project, where our sequencing pipeline is delivering 50,000 volunteers’ Introduction whole-genome sequences to aid genetic he past year has been one of great exploration of health and disease. joy and sadness: we celebrated our By marrying the wealth of genomic data 25th anniversary and we mourned T with electronic health records and other the death of our first director, John Sulston. molecular characterisation tools, our Under John’s guidance, the Sanger Institute researchers have discovered new gene determined one-third of the human reference variants associated with osteoarthritis, genome, providing a fundamental gift to life developed prognostic calculators for science research worldwide. cancer, and created an artificial intelligence It seemed most fitting to seek to make that predicts new pathogen emergence. -
Gisler Et Al the Human Genome Project 20100315
Exuberant innovation: The Human Genome Project Monika Gisler1, Didier Sornette2,3 and Ryan Woodard2 1ETH Zurich, D-ERDW, NO, CH-8092 Zürich, +41 78 919 5058 [email protected] (corresponding author) 2ETH Zurich, D-MTEC, Chair of Entrepreneurial Risks, Kreuzplatz 5, CH-8032 Zurich [email protected]; [email protected] 3Swiss Finance Institute, University of Geneva, 40 blvd. du Pont d’Arve, CH-1211 Geneva 4 “And all this back and forthing over who did what and what strategy was used and which money was public and which was private is probably going to sink below the radar screen.” (Francis Collins)1 “The prevailing view is that the genome is going to revolutionize biology, but in some way, it’s overhyped. In the end, the real insights are coming from individuals studying one gene at a time in real depth.” (Gerald Rubin)2 Abstract We present a detailed synthesis of the development of the Human Genome Project (HGP) from 1986 to 2003 in order to test the “social bubble” hypothesis that strong social interactions between enthusiastic supporters of the HGP weaved a network of reinforcing feedbacks that led to a widespread endorsement and extraordinary commitment by those involved in the project, beyond what would be rationalized by a standard cost-benefit analysis in the presence of extraordinary uncertainties and risks. The vigorous competition and race between the initially public project and several private initiatives is argued to support the social bubble hypothesis. We also present quantitative analyses of the concomitant financial bubble concentrated on the biotech sector. Confirmation of this hypothesis is offered by the present consensus that it will take decades to exploit the fruits of the HGP, via a slow and arduous process aiming at disentangling the extraordinary complexity of the human complex body. -
16233 Wellcomeaw 17-02 27/2/04 10:29 Am Page A1
16233 WellcomeAW 17-02 27/2/04 10:29 am Page a1 Annual Report and Financial Statements 2003 16233 WellcomeAW 17-02 27/2/04 10:29 am Page a2 a2 Heading to go here strapline to go here if required 16233 WellcomeAW 17-02 27/2/04 10:29 am Page 1 THE WELLCOME TRUST ANNUAL REPORT AND FINANCIAL STATEMENTS 2003 Contents Administrative Details 2 Chairman’s Statement 4 Trustee’s Report 6 Auditors’ Report 15 Consolidated Statement of Financial Activities 16 Consolidated Balance Sheet 17 Statement of Financial Activities of the Trust 18 Balance Sheet of the Trust 19 Consolidated Cash Flow Statement 20 Notes to the Financial Statements 21 Committees of the Board of Governors 49 Board of Governors 50 Executive Management 51 16233 WellcomeAW 17-02 27/2/04 10:29 am Page 2 2 Administrative Details The Wellcome Trust (the ‘Trust’) is a Board of Governors The Wellcome Trust is managed day to day charitable trust created in 1936 by the Will Sir Dominic Cadbury (Chairman) by the Executive Board and other Senior of the late Sir Henry Wellcome and now Management shown as follows: Professor Sir Michael Rutter, CBE, MD, FRS, governed by its Constitution, which was FBA, FMedSci (Deputy Chairman) established in February 2001 by a scheme Executive Board of the Charity Commission.The Trust is Professor Adrian Bird, FRS, FMedSci Dr Mark Walport, PhD, FRCP,FMedSci registered under the Charities Act 1993 Professor Martin Bobrow, CBE, DSc Med, (Director) (from 1 June 2003) (registration number 210183). FMedSci Dr Michael Dexter, DSc, FRS, FMedSci The sole trustee (the ‘Trustee’) is Professor Christopher Edwards, MD, FRSE, (Director) (retired 31 March 2003) The Wellcome Trust Limited, a company FMedSci limited by guarantee (registration number Mrs Linda Arter (Director of Finance and 2711000), whose registered office is Professor Julian Jack, PhD, FRS, FMedSci Information Management) 183 Euston Road, London NW1 2BE. -
Ca Th & Ins Mbr Herap Infe Stitu Ridg Peut Ectio Ute D Ge in Tic I Ous D
Cambridge Instit ute for Therapeuttic Immunology & Infectious Disease Institute Directory CITIID CITIID www.citiid.cam.ac.uk A PERFECT L O C A T I O N The Cambridge Institute for Therapeutic Immunology and Infectious Disease (CITIID) was established by the Department of Medicine to support both fundamental and translationaal research on human disease. CITIID houses up to 250 scientists working in research groups focussed on understanding the pathogenesis and improving the management of immune‐related disorders, as well as transforming our understanding of how infectious agents interact with humans. Later in this directory you’ll find out more about these studies. There is also a strong focus on health issuess of global importance, and on antimicrobial resistance. In particular, we work closely with key overseaas partners including universities, agencies and industry to ensure that we can increase our global impaact in a coordinated programme. CITIID brrings together geographically dispersed groups working on immunity and infection across the Cambridge Biomedical Campus, the largest Biomedical campus in Europe. By encouraging research at the clinical interface, for example in the Cambridge Clinical Research Centre and with industry, CITIID also faciilitates the translation of scientific disscoveries into clinical benefits. Its location on the Cambridge Biomedical Campus places CITIID at the centrre of the Cambridge Cluster where it benefits from the closeness of several other major health‐related organisations such as the Royal Papworth Hospital, MRC‐Laboratory of Molecular Biology, CRUK Cambridge Institute and Astra Zeneca’s global research and development headquarters. CITIID transforms immunity and infection research in Cambridge by providiing researchers with advanced facilities that enable them to optimise their work on understandding human immune, inflammatory and infectious diseases.