DOCSLIB.ORG

Ovarian Cancer

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Ovarian Cancer 113th AAO Annual Session OVERVIEW Unraveling an Association between Hypodontia and OUTLINE Epithelial Ovarian Cancer 1. Introduction Anna N Vu, DMD, MS 2. Background 3. Purpose Division of Orthodontics 4. Materials and Methods May 2013 5. Results 6. Discussion 7. Conclusion U N I V E R S I T Y O F K E N T U C K Y C O L L E G E O F D E N T I S T R Y HYPODONTIA HYPODONTIA REVIEW & CANCER • Over 300 genes are involved in odontogenesis including MSX1, PAX9, and AXIN2 HYPODONTIA • Genes involved in dental development also have roles in other organs of the body Defined as the developmental absence of one or more teeth as well as variations in size, • Mutation in several genes governing tooth development have already been associated with shape, rate of dental development and eruption time. cancer • Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer7 Hypodontia is the agenesis of 6 or less teeth. • AXIN2 gene is highly expressed in ovarian tissue so may play a role in epithelial ovarian cancer (EOC)8 Oligodontia is the agenesis of 6 or more teeth. Anodontia is the agenesis of all teeth. • Reduced expression of PAX9 can lead to hypodontia and has been correlated with increased malignancy of dysplastic and cancerous esophageal epithelium9 2.6-11.3% reported prevelance worldwide. 78 • RUNX transcription factor family (RUNX1, 2, and 3) are involved in odontogenesis and has been Women are affected more than males at a ratio of 3:2. the most targeted genes in acute myeloid leukemia and acute lymphoblastic leukemia10 Both genetic and environmental explanations for hypodontia have been reported. • RUNX2 is amplified in various cancers including osteosarcoma and may play a role in breast and prostate cancer WHAT IS WHAT IS OVARIAN CANCER? OVARIAN CANCER? • Mainly affects women over the age of 40 OVARIAN CANCER • Symptoms include: • Vaginal bleeding Ovarian cancer is a gynecological cancer that begin in the ovaries. • Pain or pressure in pelvic region or abdominal area • Back pain • Bloating 70% • Change in bathroom habits Although ovarian cancer only ranks of women • Increased risk of EOC is correlated with: 8th in most common cancer in diagnosed with • ovarian cancer Family history of ovarian cancer women…. do not survive. • Increasing age • History of breast, uterine, or colorectal cancer • Infertility …it is the 5th leading cause of cancer • Endometriosis death in women. Inside Knowledge: Ovarian Cancer. Atlanta, GA: Center for Disease Control and Prevention, May 2010. OVARIAN CANCER OVARIAN CANCER IN THE LITERATURE IN THE LITERATURE • Supports a possible association between hypodontia and EOC PURPOSE • Suggests hypodontia may potentially become a risk marker for future cancer development • Improved genetic screenings to identify persons at high risk for developing EOC JADA 2008; 139(2): 163-9. • Refer female patients to get earlier screenings for EOC • Compare prevalence rates • FINDINGS of hypodontia among Earlier EOC diagnosis and treatment could save many lives epithelial ovarian cancer (EOC) subjects and control • Prevalence of hypodontia was 20% for EOC subjects (p< .001) subjects • Explore the possible • Reported family hx of hypodontia and ovarian cancer was higher in genetic association EOC subjects between the two phenotypes • EOC subjects were 8.1 times more likely to have hypodontia than women without EOC GENE SELECTION: PURPOSE Locus 8q24 Susceptibility Loci for Ovarian Cancer PURPOSE • Previous genome wide association study (GWAS) identified a ovarian cancer susceptiblity loci at 9q22 and found a 20% reduction in risk with each copy of the minor alleles23 To investigate whether SNP rs10088218 is genetically associated with hypodontia. • Most recent GWAS identified two new susceptibility loci for ovarian cancer • 2q31 (p= 3.8 x 10-14): rs2072590 • 8q24 (p= 8.0 x 10-15): rs10088218, rs1519682 and rs10098821 NULL • SNP rs10088218 is NOT associated with hypodontia. SNPs at these two loci showed strong support for an association with ovarian cancer with p-values Hypothesis < 0.001. (HO) • At locus 8q24, minor allele (A) of SNP rs10088218 was associated with a decreased risk for ovarian cancer SNP rs10088218 is associated with hypodontia. ALTERNATIVE Hypothesis (HA) Goode EL, et al. Genome wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet 2010; 42(10): 874-81. MATERIALS MATERIALS AND METHODS AND METHODS Saliva Collection Subject Population • 2-4 mm of saliva was collected from all study participants • Oragene-DNA Collection Kits (DNA Genotek Inc., Ottawa, Ontario, Canada) • • 110 Caucasian subjects were recruited from the orthodontic clinic at the University of Preservatives in container will preserve DNA for 5+ years Kentucky College of Dentistry DNA Isolation • 67 females, 43 males • Genomic DNA extracted and resuspended in 10 mM Tris-HCl, 1 mM EDTA pH 8.0, and stored at 20° C • DNA isolated and purified via ethanol precipitation • Subjects were classified into two research groups: • DNA concentrations measured on the NanoDrop-1000 spectrophotometer (Thermo Fischer Scientific, Wilmington, DE) • Controls: patients without hypodontia Taqman® Gene Assay Kits • Subjects: patients with hypodontia • Analysis of all SNPs were performed on the genomic DNA utilizing Taqman® Genotyping Assay Kits on Roche LightCycler 480® • Following RT-PCR amplification, each SNP allele was identified using allelic specific probes • VIC or FAM fluorescence • Analyze SNP rs10088218 MATERIALS RESULTS AND METHODS SNP rs10088218 Statistical Methods Frequency of Missing • Genotyping of SNP rs10088218 was completed in all 30 subjects with Teeth NMT and 80 controls. • Same as previously • 2 The Chi-Square (x ) Analysis • reported No deviation from HWE was observed in either the controls or the • Used to evaluate the potential association of each SNP with hypodontia entire cohort. • Maxillary lateral incisor • Co-dominant mode on inheritance was utilized for potential association was the most commonly • SNP rs10088218 was significantly associated with the presence of • Significance set at an alpha of 5% (p<0.05) missing tooth hypodontia in 25 individuals versus 80 controls (p=0.019) with an odds ratio (OR) of 11.51 (95% confidence interval (CI) 1.49-88.98) • The next most commonly under an additive mode of inheritance (MOI). missing tooth type included the mandibular • SNP rs10088218 was also significantly associated with the presence second premolars of hypodontia in 30 individuals versus 80 controls (p=0.021; OR=4.37 followed by maxillary second premolars 95%CI: 1.25-15.35) under an additiven= 3 MOI. n= 0 • Females affected more than males at a ratio of 3:1 RESULTS DISCUSSION SNP rs10088218 & CONCLUSIONS Number of individuals within the group with Conclusions a given genotype OR* Group (% of the total group) (95% Confidence p-Value • Hypodontia patients GG AG AA Interval) (%) (%) (%) are 11.5x more likely • Hypodontic teeth reported in this study are consistent with those previously Hypodontia to be homozygous for reported missing in women diagnosed with EOC and hypodontia 24 1 0 Subjects Only the G allele than (96.0) (4.0) (0) 11.51 n=25 0.019 (95% CI:1.49-88.98 ) controls • The null hypothesis was rejected Controls 54 23 3 n=80 (67.5) (28.75) (3.75) • Odds ratio reduces • SNP rs10088218 is significantly associated with the occurrence of hypodontia Hypodontia with addition of (p= 0.019) and 27 3 0 oligodontia patients Oligodontia (90.0) (10.0) (0) 4.37 Subjects 0.021 (95% CI: 1.25-15.35) n=30 Controls 54 23 3 n=80 (67.5) (28.75) (3.75) FUTURE REFERENCES DIRECTION 1. Arte S and S Pirinen. Hypodontia. Orphanet Encyclopedia. 2004. 2. Peck S et al. Site –specificity of tooth agenesis in subjects with maxillary canine malpositions. Angle Orthod 1996; 66: 473- • 476. Continue to expand the sample size in order to increase the power of the study 3. Al-Nimri KS and E Bsoul. Maxillary palatal canine impaction displacement in subjects with congenitally missing maxillary lateral incisors. Am J Orthod Dentofacial Orthop 2011; 140(1): 81-86. • Test for association of SNP rs10088218 with ovarian cancer in EOC patients 4. Jena AK and R Duggal. The pattern of maxillary canine impaction in relation to anomalous lateral incisors. J Clin Pediatr Dent 2010; 35(1): 37-40. • Look at other potential markers 5. DeCoster PJ et al. Dental Agenesis: Genetic and Clinical Perspectives. J Oral Pathol Med (2009). 38: 1-17. 6. Beeman CS. Prevalence of hypodontia in north america: regional and international comparisons. University of Kentucky. • SNP rs2072590 that has been associated with an increased risk for ovarian caner Lexington, KY 2009. Lecture. 7. Lammi L, et al. Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am J Hum Genet • WNT 10A which has been associated with hypodontia and has a presence in ovarian tissue 2004; 74(5): 1043-50. 8. Dong X, et al. Genomic structure, chromosome mapping and expression analysis of the human AXIN2 gene. Cytogenet Cell • Test these SNPs in ovarian cancer patients to find a common gene involved with both hypodontia Genet 2001; 93 (1-2): 26-8. and ovarian cancer 9. Gerber JK, et al. Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human esophagus. J Pathol 2002; 197(3): 293-7. 10. Song H et al. A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet 2009; 41: 996-1000. RESEARCH REFERENCES SUPPORT 11. Ohno K and Ohmori I. Anodontia with hypohidrotic ectodermal dysplasia in a young female: a case report. Pediatric Dentistry 2000; 22(1): 49-52. 12. Fleischmannova J et al. Formation of the tooth-bone interface. J Dent Res 2010;89:108-115. 13. Inside Knowledge: Ovarian Cancer. Atlanta, GA: Center for Disease Control and Prevention, May 2010.
Load more

Recommended publications
  • Oral Health in Prevalent Types of Ehlers–Danlos Syndromes
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Ghent University Academic Bibliography J Oral Pathol Med (2005) 34: 298–307 ª Blackwell Munksgaard 2005 Æ All rights reserved www.blackwellmunksgaard.com/jopm Oral health in prevalent types of Ehlers–Danlos syndromes Peter J. De Coster1, Luc C. Martens1, Anne De Paepe2 1Department of Paediatric Dentistry, Centre for Special Care, Paecamed Research, Ghent University, Ghent; 2Centre for Medical Genetics, Ghent University Hospital, Ghent, Belgium BACKGROUND: The Ehlers–Danlos syndromes (EDS) Introduction comprise a heterogenous group of heritable disorders of connective tissue, characterized by joint hypermobility, The Ehlers–Danlos syndromes (EDS) comprise a het- skin hyperextensibility and tissue fragility. Most EDS erogenous group of heritable disorders of connective types are caused by mutations in genes encoding different tissue, largely characterized by joint hypermobility, skin types of collagen or enzymes, essential for normal pro- hyperextensibility and tissue fragility (1) (Fig. 1). The cessing of collagen. clinical features, modes of inheritance and molecular METHODS: Oral health was assessed in 31 subjects with bases differ according to the type. EDS are caused by a EDS (16 with hypermobility EDS, nine with classical EDS genetic defect causing an error in the synthesis or and six with vascular EDS), including signs and symptoms processing of collagen types I, III or V. The distribution of temporomandibular disorders (TMD), alterations of and function of these collagen types are displayed in dental hard tissues, oral mucosa and periodontium, and Table 1. At present, two classifications of EDS are was compared with matched controls.
    [Show full text]
  • 2021 Follow-Up After Emergency Department Visits for Non-Traumatic Dental Conditions in Adults
    DQA Measure EDF-A-A Effective January 1, 2021 **Please read the DQA Measures User Guide prior to implementing this measure.** DQA Measure Specifications: Administrative Claims-Based Measures Follow-up after Emergency Department Visits for Non-Traumatic Dental Conditions in Adults Description: The percentage of ambulatory care sensitive non-traumatic dental condition emergency department visits among adults aged 18 years and older in the reporting period for which the member visited a dentist within (a) 7 days and (b) 30 days of the ED visit Numerators: Number of ambulatory care sensitive non-traumatic dental condition ED visits in the reporting period for which the member visited a dentist within (a) 7 days (NUM1) and (b) 30 days (NUM2) of the ED visit Denominator: Number of ambulatory care sensitive non-traumatic dental condition ED visits in the reporting period Rates: NUM1/DEN and NUM2/DEN Rationale: The use of emergency departments (EDs) for non-traumatic dental conditions has been a growing public health concern across the United States (US)1,2,3,4,5,6,7,8 with over 2 million visits occurring in 2015.9 The majority of ED visits are semi-urgent (53.8%) or non-urgent (23.9%)10, which can be better managed in an ambulatory care setting. Dental care in an ED setting is not definitive with limited care continuity that ultimately leads to poor oral health outcomes.11,12,13 This process of care measure can be used to assess if the patient had timely follow-up with a dentist for more definitive care. References: 1.
    [Show full text]
  • Non-Syndromic Occurrence of True Generalized Microdontia with Mandibular Mesiodens - a Rare Case Seema D Bargale* and Shital DP Kiran
    Bargale and Kiran Head & Face Medicine 2011, 7:19 http://www.head-face-med.com/content/7/1/19 HEAD & FACE MEDICINE CASEREPORT Open Access Non-syndromic occurrence of true generalized microdontia with mandibular mesiodens - a rare case Seema D Bargale* and Shital DP Kiran Abstract Abnormalities in size of teeth and number of teeth are occasionally recorded in clinical cases. True generalized microdontia is rare case in which all the teeth are smaller than normal. Mesiodens is commonly located in maxilary central incisor region and uncommon in the mandible. In the present case a 12 year-old boy was healthy; normal in appearance and the medical history was noncontributory. The patient was examined and found to have permanent teeth that were smaller than those of the average adult teeth. The true generalized microdontia was accompanied by mandibular mesiodens. This is a unique case report of non-syndromic association of mandibular hyperdontia with true generalized microdontia. Keywords: Generalised microdontia, Hyperdontia, Permanent dentition, Mandibular supernumerary tooth Introduction [Ullrich-Turner syndrome], Chromosome 13[trisomy 13], Microdontia is a rare phenomenon. The term microdontia Rothmund-Thomson syndrome, Hallermann-Streiff, Oro- (microdentism, microdontism) is defined as the condition faciodigital syndrome (type 3), Oculo-mandibulo-facial of having abnormally small teeth [1]. According to Boyle, syndrome, Tricho-Rhino-Phalangeal, type1 Branchio- “in general microdontia, the teeth are small, the crowns oculo-facial syndrome. short, and normal contact areas between the teeth are fre- Supernumerary teeth are defined as any supplementary quently missing” [2] Shafer, Hine, and Levy [3] divided tooth or tooth substance in addition to usual configuration microdontia into three types: (1) Microdontia involving of twenty deciduous and thirty two permanent teeth [7].
    [Show full text]
  • Feline Health Topics for Veterinarians
    Feline Health Topics for veterinarians Volume 6 , Number 4 Feline Oral and Dental Diseases John E. Saidla, D.V.M. Although oral and dental diseases occur frequently The maxillary PM’s are PM2, PM3 and PM4, in the cat, they are often overlooked. Performing an while the mandibular are PM3 and PM4. The decidu­ oral examination on a cat can be problematic, partially ous incisors and canine teeth of the cat erupt between due to the relatively tight lips that surround the cat’ s 3 to 4 weeks and the premolars between 5 to 6 weeks. small oral cavity. Also, many of the common dental The incisors are replaced between 3 1/2 and 5 1/2 and oral problems cause significant pain, making months, the canines between 5 1/2 and 61/2 months, cats even less tolerant of the examination. Therefore, the premolars between 4 to 5 months, and the molars anesthesia or sedation is usually required to perform between 5 to 6 months. a thorough oral examination and radiography of the Permanent Dentition: cat’ s mouth. (13/3, C l/1 , PM 3/2, M l/1 ) x 2 = 30 teeth Anatomy The camassial teeth are maxillary PM4 and man­ Knowing the dental anatomy and formulas are espe­ dibular M l. The premolars are designated the same cially important since cats have fewer teeth as numbers as in the deciduous dentition.7 There is one compared to other mammals. Knowing which teeth root for each incisor and canine tooth, the maxillary are anatomically missing improves the probability PM3 has two roots, PM4 has three roots, M l has two that one can identify truly missing teeth.
    [Show full text]
  • Current Approaches for Tooth Agenesis: a Review
    Atatürk Üniv. Diş Hek. Fak. Derg. Derleme/ ŞENTÜRK, Review ULU GÜZEL J Dent Fac Atatürk Uni Cilt:29, Sayı:2, Yıl: 2019, Sayfa, 332-339 CURRENT APPROACHES FOR TOOTH AGENESIS: A REVIEW DIŞ EKSIKLIĞINDE GÜNCEL YAKLAŞIMLAR: DERLEME Arş. Gör. Dt. Özge ŞENTÜRK* Dr. Öğr. Üyesi Kadriye Görkem ULU GÜZEL* Makale Kodu/Article code: 3126 Makale Gönderilme tarihi: 10.11.2016 Kabul Tarihi: 29.12.2016 ABSTRACT ÖZ Hypodontia is defined as the congenital deficiency of one or more teeth and is one of the most common Hipodonti, bir veya daha fazla dişin konjenital eksikliği dental anomalies in humans. Multifactorial etiology can olarak tanımlanır ve insanlarda en sık görülen dental include environmental factors as well, since a anomalilerden biridir. Genetik faktörlerin yanısıra combination of environmental and genetic factors çevresel faktörler veya bunların kombinasyonu diş might contribute to the occurrence of dental agenesis. eksikliklerinin görülmesine sebep olabilmektedir. Eksik Patient with missing teeth; reduced masticatory dişlere sahip hastalar; azalmış çiğneme yeteneği, ability, inarticulate pronunciation may encounter telaffuzun anlaşılamaması, estetik ve periodontal esthetics and periodontal problems. Tooth agenesis problemlerle karşılaşabilmektedir. Bu derlemede definition, etiology, genes that cause tooth agenesis konjenital diş eksikliği tanımı, etiyolojisi, diş eksikliğine and treatment of tooth agenesis is mentioned in this sebep olan genler ve tedavisinden bahsedilmektedir. review. Nowadays, many genes which play role in Günümüzde, diş
    [Show full text]
  • Association of Taurodontism with Hypodontia: a Controlled Study W
    PEDIATRICDl~NTISTRY/Copyright © "i989 by The AmericanAcademy of Pediatric Dentistry Volume 11, Number3 Association of taurodontism with hypodontia: a controlled study W. Kim Seow, BDS, MDSc, PhD, FRACDS P.Y. Lai, BDSc Abstract Although taurodontism has been reported in many been suggested for both taurodontism (Jorgenson 1982; syndromeswhich also lea t u re hypodontia, there have been no Hamneret al. 1964) as well as hypodontia (Barjian 1960), previous investigations on the prevalence of taurodontismin it is likely that these two traits may be associated. patients with hypodontia. Using a novel biometric methodfor Further support of this concept is the fact that the assessment of taurodontism, we found that 34.8%of 66 taurodontism also may be observed in amelogenesis patients with hypodontia had at least one mandibularfirst imperfecta (Witkop and Sauk 1971), a defect permanent molar which showed taurodontism compared to ectodermal origin. In this study we investigated the only 7.5% of a control group without hypodontia. The trait prevalence of taurodontism in a group of children with may be seen both unilaterally and bilaterally and is most hypodontia compared to a control group. To establish frequently seen in patients with multiple missing teeth. The the diagnosis of taurodontism objectivity, a novel results indicate that clinicians should be alerted to the biometric technique was employed. possibility of taurodontism with its accompanyingclinical difficulties in patients with hypodontia. Materials and methods Introduction Patients with hypodontia Randomscreening of 1032 patient records which had The term taurodontism was first used by Keith in panoramic radiographs from the pediatric dental clinic 1913 to describe the molars of Neanderthal human at the University of Queensland Dental School revealed fossils which "had a tendency for the body of the tooth that 66 patients (6.4%) had agenesis of at least one tooth.
    [Show full text]
  • Concomitant Mandibular Hypo-Hyperdontia: Report of Two Rarest Cases with the Literature Review
    International Journal of Contemporary Dental and Medical Reviews (2014), Article ID 091214, 6 Pages REVIEW ARTICLE Concomitant mandibular hypo-hyperdontia: Report of two rarest cases with the literature review N. B. Nagaveni, Meghna Bajaj, Kirthiga Muthusamy, P. Poornima, Suryakanth M. Pai, V. V. Subba Reddy Department of Pedodontics and Preventive Dentistry, College of Dental Sciences, Davangere, Karnataka, India Correspondence Abstract Dr. N.B. Nagaveni, Department of Pedodontics Concomitant occurrence of both hypodontia (congenital tooth agenesis) and and Preventive Dentistry, College of Dental hyperdontia (supernumerary tooth) in the same dental arch is an extremely rare dental Sciences, Davangere, Karnataka, India. Email: anomaly. Literature search shows very few cases of this anomalous condition with all [email protected] cases depicting the unilateral presence of supernumerary tooth. Therefore, the intention Received 16 December 2014; of the current article is to report two cases of concomitant occurrence of mandibular both Accepted 18 January 2015 hypo-hyperdontia. In that one case exhibited bilateral occurrence of mesiodens teeth in the midline of mandible with associated agenesis of permanent both central incisors doi: 10.15713/ins.ijcdmr.22 and taurodontism in permanent molars, which is not published so far. The article also provides comprehensive literature review on this rarest clinical entity. How to cite the article: N. B. Nagaveni, Meghna Bajaj, Kirthiga Keywords: Mandibular mesiodens, supernumerary tooth, tooth agenesis Muthusamy, P. Poornima, Suryakanth M. Pai, V. V. Subba Reddy, “Concomitant mandibular hypo-hyperdontia: Report of two rarest cases with literature review”, Int J Contemp Dent Med Rev, Vol. 2014, Article ID: 091214, 2014. doi: 10.15713/ins.ijcdmr.22 Introduction same patient.
    [Show full text]
  • Emergency Department Visits Involving Dental Conditions, 2018
    HEALTHCARE COST AND Agency for Healthcare UTILIZATION PROJECT Research and Quality Emergency Department Visits Involving Dental Conditions, 2018 STATISTICAL BRIEF #280 August 2021 Highlights ■ In 2018, there were more than 2 Pamela L. Owens, Ph.D., Richard J. Manski, D.D.S., M.B.A., million dental-related Ph.D., and Audrey J. Weiss, Ph.D. emergency department (ED) visits, which represented 615.5 Introduction visits per 100,000 population. Oral health contributes to overall wellbeing and improved quality ■ The highest population rates of of life. Untreated poor dental health also can lead to negative dental-related ED visits were general health outcomes.1 Most oral diseases tend to be among non-Hispanic Black progressive and cumulative without intervention.2 Tooth decay individuals, individuals aged 18– and periodontal disease are among the most prevalent chronic 44 years, and those residing in diseases worldwide and have been shown to be associated with the lowest income communities, a number of life-threatening conditions, including sepsis, (rates of 1,362.4, 1,107.4, and diabetes, and heart disease.2,3 Despite the increasing need for 1,069.1 per 100,000 population, dental care, many Americans delay or do not receive it. Failure to respectively). receive treatment may make necessary the provision of less ■ A higher proportion of dental- definitive and more costly care. Individuals who lack a usual related than non-dental-related source for dental care may visit hospital emergency departments ED visits were expected to be 4,5 (EDs) to seek relief for dental pain and related conditions. The paid by Medicaid (42 vs.
    [Show full text]
  • Billing and Coding: Routine Dental Services Local Coverage Article
    Local Coverage Article: Billing and Coding: Routine Dental Services (A52977) Links in PDF documents are not guaranteed to work. To follow a web link, please use the MCD Website. Contractor Information CONTRACTOR NAME CONTRACT TYPE CONTRACT NUMBER JURISDICTION STATE(S) Noridian Healthcare Solutions, LLC A and B MAC 02101 - MAC A J - F Alaska Noridian Healthcare Solutions, LLC A and B MAC 02102 - MAC B J - F Alaska Noridian Healthcare Solutions, LLC A and B MAC 02201 - MAC A J - F Idaho Noridian Healthcare Solutions, LLC A and B MAC 02202 - MAC B J - F Idaho Noridian Healthcare Solutions, LLC A and B MAC 02301 - MAC A J - F Oregon Noridian Healthcare Solutions, LLC A and B MAC 02302 - MAC B J - F Oregon Noridian Healthcare Solutions, LLC A and B MAC 02401 - MAC A J - F Washington Noridian Healthcare Solutions, LLC A and B MAC 02402 - MAC B J - F Washington Noridian Healthcare Solutions, LLC A and B MAC 03101 - MAC A J - F Arizona Noridian Healthcare Solutions, LLC A and B MAC 03102 - MAC B J - F Arizona Noridian Healthcare Solutions, LLC A and B MAC 03201 - MAC A J - F Montana Noridian Healthcare Solutions, LLC A and B MAC 03202 - MAC B J - F Montana Noridian Healthcare Solutions, LLC A and B MAC 03301 - MAC A J - F North Dakota Noridian Healthcare Solutions, LLC A and B MAC 03302 - MAC B J - F North Dakota Noridian Healthcare Solutions, LLC A and B MAC 03401 - MAC A J - F South Dakota Noridian Healthcare Solutions, LLC A and B MAC 03402 - MAC B J - F South Dakota Noridian Healthcare Solutions, LLC A and B MAC 03501 - MAC A J - F Utah Noridian Healthcare Solutions, LLC A and B MAC 03502 - MAC B J - F Utah Noridian Healthcare Solutions, LLC A and B MAC 03601 - MAC A J - F Wyoming Noridian Healthcare Solutions, LLC A and B MAC 03602 - MAC B J - F Wyoming Article Information General Information Article ID Original Effective Date A52977 10/01/2015 Article Title Revision Effective Date Created on 05/19/2020.
    [Show full text]
  • On the Genetics of Hypodontia and Microdontia: Synergism Or Allelism of Major Genes in a Family with Six Affected Members
    JMed Genet 1996;33:137-142 137 On the genetics of hypodontia and microdontia: synergism or allelism of major genes in a family J Med Genet: first published as 10.1136/jmg.33.2.137 on 1 February 1996. Downloaded from with six affected members S P Lyngstadaas, H Nordbo, T Gedde-Dahl Jr, P S Thrane Abstract and epigenetic factors.7 In a large study oftooth Familial severe hypodontia of the per- number and size in British schoolchildren, ex- manent dentition is a rare condition. The cluding patients with more widespread ab- genetics ofthis entity remains unclear and normalities, Brook3 favoured a multifactorial several modes of inheritance have been model with a continuous spectrum, related to suggested. We report here an increase in tooth number and size, with thresholds, and the number of congenitally missing teeth where position on the scale depends upon the after the mating of affected subjects from combination of numerous genetic and en- two unrelated Norwegian families. This vironmental factors, each with a small effect. condition may be the result of allelic mut- In this study the proportion ofaffected relatives ations at a single gene locus. Alternatively, varied with the severity of the condition in the incompletely penetrant non-allelic genes probands and an association between hy- may show a synergistic effect as expected podontia and microdontia was noted. for a multifactorial trait with interacting Other causes of hypodontia have been sug- gene products. This and similar kindreds gested and include an evolutionary trend to- may allow identification of genes involved wards fewer teeth,28 infections during in growth and differentiation of dental tis- pregnancy and early childhood, hormonal dys- sues by linkage and haplotype association function, which itself may be inherited, and analysis.
    [Show full text]
  • The Investigation of Major Salivary Gland Agenesis: a Case Report
    Oral Pathology The investigation of major salivary gland agenesis: A case report T.A. Hodgson FDS, RCS, MRCP(UK) R. Shah FDS, RCS S.R. Porter MD, PhD, FDS, RCS, FDS, RCSE Dr. Hodgson is a specialist registrar and professor, and Dr. Porter is a consultant and head of department, Department of Oral Medicine; Dr. Shah is senior house officer, Department of Pediatric Dentistry , Eastman Dental Institute for Oral Health Care Sciences, University College London. Correspond with Dr. Hodgson at [email protected] Abstract Salivary gland agenesis is an extremely uncommon congenital The present report details a child with rampant dental car- anomaly, which may cause a profound xerostomia in children. The ies secondary to xerostomia. Despite having oral disease for oral sequelae includes dental caries, candidosis, and ascending many years, the congenital absence of all the salivary glands sialadenitits. failed to be established until late adolescence, and, therefore, The present report details a child with rampant dental caries appropriate replacement therapy was not instituted, until this secondary to xerostomia. Despite having oral disease for many years, time, to prevent further oral disease. the congenital absence of all the salivary glands failed to be estab- lished until early adulthood. Case report The appropriate investigation and management of the In 1988, a 41/2-year-old Caucasian female was referred to the xerostomic child allows a definitive diagnosis to be made and at- Department of Pediatric Dentistry of the Eastman Dental In- tention focused on the prevention and treatment of resultant oral stitute for Oral Health Care Sciences for the extraction of disease.
    [Show full text]
  • Radiographic Assessment of Third Molars Agenesis Patterns in Young Adults
    Pesquisa Brasileira em Odontopediatria e Clínica Integrada 2021; 21:e0212 https://doi.org/10.1590/pboci.2021.076 ISSN 1519-0501 / eISSN 1983-4632 ORIGINAL ARTICLE Radiographic Assessment of Third Molars Agenesis Patterns in Young Adults Anahat Chugh1 , Komal Smriti1 , Anupam Singh2 , Mathangi Kumar3 , Kalyan Chakravarthy Pentapati1 , Srikanth Gadicherla2 , Chehak Nayyar1 , Shreshth Kapoor4 1Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. 2Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. 3Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. 4Department of Public Health Dentistry, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. Correspondence: Komal Smriti, Department of Oral Medicine & Radiology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India. E-mail: [email protected] Academic Editor: Alessandro Leite Cavalcanti Received: 28 September 2020 / Review: 14 December 2020 / Accepted: 07 January 2021 How to cite: Chugh A, Smriti K, Singh A, Kumar M, Pentapati KC, Gadicherla S, Nayyar C, Kapoor S. Radiographic assessment of third molars agenesis patterns in young adults. Pesqui Bras Odontopediatria Clín Integr. 2021; 21:e0212. https://doi.org/10.1590/pboci.2021.076 ABSTRACT Objective: To determine the prevalence of third molar agenesis and associated characteristics. Material and Methods: A total of 2374 panoramic radiographs were retrieved from the radiological archives and evaluated in a computer monitor under optimum viewing conditions. The basic demographic data (age and sex) and the primary findings regarding the presence or absence of third molars in the maxillary and mandibular arches were recorded systematically in a specially designed proforma.
    [Show full text]