Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000685155Cyc: Candidatus Methanoperedens nitroreducens ANME-2d Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari ammonium ammonium

RS09775 RS02215 RS00485 RS06370 RS13550 RS13525 RS01585 RS00340 ArtA RS06195 RS17195 RS14270 RS06145 RS04920 RS16655 RS16770 RS17150 RS06000 RS04805 RS05990 RS02975 CbiQ RS13050 RS00065 RS14835 RS13020 RS13015 PstA RS13000 RS01210 RS07675 RS00025 RS02885 RS11865 RS04600 RS04580 RS07625 RS09695 RS05840 RS16915 RS12860 RS10355 RS15190 RS08995 RS14890 RS04575 RS02865 RS09770 Amt Amt RS14985 RS01215 RS07690 PstC RS00050 RS04745 RS11715 RS11050 CbiM RS15110 RS00080 RS05985 RS15155 RS13080 RS06010 RS16280 RS01875 ArsB RS16605 RS09795 RS17190 RS13260 RS13285 RS02045 RS13880 RS13460 RS06335 RS14640 RS03780 RS10680 RS08165 RS01085 RS12855 RS06990 RS01080 RS02765 RS14810 RS07535 RS05775 RS09540 RS09535 RS14730 RS04400 RS06970 RS01045 RS04395 RS06960 RS14715 RS17125 RS01035 RS04375 RS14700 LonB RS04360 RS04355 RS06940

PhnE RS15720

ammonium ammonium

RS08190 RS05245

RS06410 Nucleoside and Nucleotide Degradation RS16440 Aromatic Compound Biosynthesis RS09790 an inactive D-glucopyranose a guanine 34 an N-terminal- an N-terminal- an N-terminal- an N-terminal- a [protein]-L- a reduced gln ATP biosynthesis nucleoside and nucleotide degradation (archaea) α glutaminyl-tRNA Aminoacyl-tRNA Charging chorismate biosynthesis II (archaea) a reduced UDP- -D-glucose 2-methylbutanoate MoO - preQ superoxide 5 PRPP quinolinate methanogenesis from H and CO Respiration ribonucleoside SAM 6-phosphate 2 1 in tRNA L-methionyl-L- L-methionyl-L- L-methionyl-L- L-methionyl- glutamate-O factor 420 L-asparagine biosynthesis III (tRNA-dependent) L-cysteine biosynthesis 2 2 flavodoxin ATP GTP biosynthesis via transamidation triphosphate a tRNA precursor molybdopterin cysteinyl-[protein] threonyl-[protein] alanyl-[protein] glycyl-[protein] -methyl-ester NADPH- RS05515 II (tRNA-dependent) D-glyceraldehyde CTP reductase cofactor dependent RS02210 3-phosphate CO ADP adenosine guanosine bifunctional CO tRNA superoxide carboxylating glu asp O-phospho- 2 type II methionyl type II methionyl type II methionyl type II methionyl chemotaxis F420 ATP synthase uridine alpha,alpha- dehydrogenase/ guanosine(34) dismutase: nicotinate- reductase: L-serine formylmethanofuran anaerobic tRNA CCA- molybdopterin- aminopeptidase: aminopeptidase: aminopeptidase: aminopeptidase: response O-phosphoserine- asp archaeal: cytidine trehalose-phosphate acetyl-CoA transglycosylase ANME2D_RS01190 nucleotide npdG RS15630 aspartate-- dehydrogenase: ribonucleoside- pyrophosphorylase: guanine ANME2D_RS10985 ANME2D_RS10985 ANME2D_RS10985 ANME2D_RS10985 regulator protein- -tRNA ligase: ANME2D_RS09900 synthase (UDP- synthase Tgt: tgt superoxide diphosphorylase: tRNA(Asn) ANME2D_RS07900 triphosphate ANME2D_RS08065 dinucleotide glutamate NADPH- RS10670 ANME2D_RS16200 enolaldehyde aspartate kinase: ANME2D_RS09905 forming)/trehalose- complex: type II methionyl type II methionyl dismutase: type II methionyl type II methionyl nadC ligase: aspS an O-phospho-L- [+ 3 isozymes] AMP reductase CCA tRNA biosynthesis methylesterase: dependent Cys ANME2D_RS00225 ANME2D_RS09910 phosphatase: cdhA cdhB a 7-aminomethyl-7- aminopeptidase: aminopeptidase: ANME2D_RS01195 aminopeptidase: aminopeptidase: an L-glutamyl- seryl-[tRNA ] UMP CMP protein B: mobB an L-aspartyl- ANME2D_RS09915 α-D-ribose-1-phosphate activating protein: nucleotidyltransferase: 34 ANME2D_RS04550 ANME2D_RS04550 ANME2D_RS04550 ANME2D_RS04550 cheB F420 [tRNA Gln ] ANME2D_RS09220 [+ 2 isozymes] deazaguanosine RS00470 gln Asn a formylmethanofuran ANME2D_RS00645 guanine reductase: gln [tRNA ] O-phospho- L-aspartyl- ahaC ANME2D_RS10975 molybdenum cofactor in tRNA NaMN AMP phosphorylase: AMP phosphorylase: AMP phosphorylase: hydrogen npdG Asp-tRNA(Asn) Asp-tRNA(Asn) L-seryl- 4-phosphate formylmethanofuran-- ANME2D_RS09925 guanylyltransferase: O α RS14590 β α α an N-terminal L- an N-terminal L- 2 an N-terminal L- an N-terminal a [protein]- - /Glu-tRNA(Gln) asparagine tRNA:Cys- -D-fructose 1,6- ANME2D_RS06720 ANME2D_RS06720 ANME2D_RS06720 , -trehalose UDP (2S)-2- ANME2D_RS07650 peroxide MeOH an oxidized asparagine /Glu-tRNA(Gln) methylglyoxal tetrahydromethanopterin ANME2D_RS09935 an active a tRNA met cysteinyl-[protein] met threonyl-[protein] met alanyl-[protein] met glycyl-[protein] L-glutamate amidotransferase: synthetase B: tRNA bisphosphate aspartate- 5'-deoxyadenosine a flavodoxin 6-phosphate methylbutanoyl- diphosphate factor 420 synthetase B: amidotransferase: N-formyltransferase: fhcD ahaH met ribonucleoside AMP containing a RS05180 gatC gatA gatB ANME2D_RS07300 synthase: semialdehyde semiquinone CoA gatC gatA gatB ATP α-D-ribose 1,5-bisphosphate triphosphate 3' CCA end guanylyl ANME2D_RS07300 [+ 14 isozymes] dehydrogenase: 5-formyl- [+ 2 isozymes] a 4-phosphooxy- pscS reductase molybdenum RS06380 [+ 14 isozymes] a 5-phosphooxy- asd tetrahydromethanopterin S-methyl-5'- ammonium L-aspartyl- an L-cysteinyl- ribose 1,5-bisphosphate cofactor L-glutamyl- Asn 6-deoxy-5- methenyltetrahydromethanopterin thioadenosine ammonium [tRNA ] [tRNA Cys ] L-aspartate 4- isomerase: RS00445 [tRNA Gln ] ketofructose cyclohydrolase: mch degradation II semialdehyde ANME2D_RS09945 α a 7-aminomethyl-7- a 2'- peptidyl-tRNA 1-phosphate S-methyl-5'- GDP- -D- trans,octacis a [bis(guanylyl (indol-3- a ribonucleoside a [2-oxoglutarate D-ribulose an N-terminal- Asp-tRNA(Asn) 34 coenzyme A acetyl-CoA propanoyl-CoA hydrolase: H 5,10-methenyltetrahydromethanopterin thioadenosine mannose -decaprenyl deazaguanosine SAM deoxyribonucleoside [DNA] gly molybdopterin) cys yl)pyruvate formate dehydrogenase 5-phosphate L-methionyl-L- a protein a tRNA Asx asp RS10605 Asp-tRNA(Asn) /Glu-tRNA(Gln) 2 D-ribulose-1,5-bisphosphate a tetrahydrofolate triphosphate ATP S-methyl-5'- in tRNA 5'-triphosphate 6 /Glu-tRNA(Gln) ANME2D_RS04865 phosphate cofactor E2 protein] N valyl-[protein] ATP-dependent amidotransferase: thioadenosine anaerobic RS11510 amidotransferase: type III ribulose- chaperone]- -dihydrolipoyl- Clp protease gatC gatA gatB cys phosphorylase: polyprenol indolepyruvate acetyl-CoA C- dihydrolipoyl 3,4- ribonucleoside- gatC gatA gatB 2-amino-3,7- bisphosphate tRNA preQ1(34) S- DNA polymerase glycine cleavage L-cysteine anaerobic L-lysine type II methionyl proteolytic subunit: aspartate-- mtnP monophosphomannose ferredoxin acetyltransferase: dehydrogenase: dihydroxy-2- triphosphate dideoxy-D-threo- carboxylase: rbcL adenosylmethionine II large subunit: system protein H: ribonucleoside- aminopeptidase: ANME2D_RS06220 tRNA(Asn) RS03360 [+ 2 isozymes] an L-asparaginyl- 5-MTR-1-P synthase: oxidoreductase ANME2D_RS03095 ANME2D_RS10875 butanone-4- reductase: nrdD hept-6-ulosonate 5,10-methylene- ribosyltransferase- ANME2D_RS03350 ANME2D_RS05705 triphosphate ANME2D_RS10985 ligase: aspS Asn cysteine subunit alpha: phosphate ATP-dependent RS13520 [tRNA ] 3-dehydroquinate tetrahydromethanopterin 3-phospho-D-glycerate ANME2D_RS13455 reductase: nrdD [+ 2 isozymes] dihydrolipoyl dATP an L-glutaminyl- isomerase QueA: queA DNA-directed glycine cleavage desulfurase ANME2D_RS01500 synthase: type II methionyl Clp protease tRNA charging synthase II: polyprenol a [2-oxoglutaratedehydrogenase: [tRNA Gln ] 5,10-methylenetetrahydromethanopterin DNA polymerase system protein NifS: nifS ribB aminopeptidase: proteolytic subunit: ANME2D_RS07000 monophosphomannose lpdA an L-aspartyl- reductase: mer 34 II small subunit: a 2'- 3-oxopentanoyl- dehydrogenase RS13545 an epoxyqueuosine H: gcvH [+ 2 isozymes] ANME2D_RS04550 ANME2D_RS10935 Asx synthase: (indol-3 yl) deoxyribonucleoside CoA E2 protein] N 6 [tRNA ] phe a tRNA Phe 3-dehydroquinate met in tRNA ANME2D_RS04740 RS08375 5 Carbohydrate Degradation ANME2D_RS13530 adenine acetyl-CoA 1-deoxy-L- a peptide N -methyltetrahydromethanopterin UTP and CTP dephosphorylation I 5'-triphosphate -lipoyl-L-lysine formate a 5,10- a [bis(guanylyl glycero-tetrulose an N-terminal type I 3- a tRNA Ala ala trans,octacis- methylenetetrahydrofolate ala molybdopterin) 4-phosphate met L-valyl-[protein] phenylalanine--tRNA elongator dehydroquinate tetrahydromethanopterin methyl-coenzyme M D-mannose degradation UTP [DNA] tRNA asp asp gly a tRNA Gly glu a tRNA glu trp a tRNA Trp leu a tRNA Leu ile a tRNA Ile thr a tRNA Thr met initiator tRNA Met met decaprenylphospho- cofactor RS10515 ligase subunit beta: tRNA Met dehydratase: aroD S-methyltransferase: reduction to methane GDP Val Cys Tyr His Lys Pro Arg ser β chaperone]-S- RS10640 val a tRNA cys a tRNA tyr a tRNA his a tRNA lys a tRNA pro a tRNA arg a tRNA ser a tRNA ANME2D_RS02330 D-mannopyranose -D-mannose ANME2D_RS07115 alanine- asn tRNA Asn gln a tRNA Gln CTP synthase sulfanyl-L-cysteine 3-dehydroshikimate ANME2D_RS02335 methyl-CoM 6-phosphate aspartate-- glycine- glutamate-- tryptophan-- phenylalanine--tRNA leucine- isoleucine-- threonine-- -tRNA methionine- methionine- (glutamine ANME2D_RS02340 coenzyme-B mannose-1-phosphate tRNA(Asn) -tRNA valine--tRNA ligase: cysteine--tRNA ligase: tyrosine--tRNA ligase: tRNA ligase: tRNA ligase: ligase subunit alpha: histidine--tRNA ligase: -tRNA tRNA ligase: lysine--tRNA ligase: proline--tRNA ligase: tRNA ligase: arginine--tRNA ligase: ligase: -tRNA -tRNA serine--tRNA ligase: shikimate guanylyltransferase/ hydrolyzing) UDP RS00410 mtrB ANME2D_RS02350 sulfoethylthiotransferase: : pyrG a 2'- a 2'- 6-O-trans- a [lipoyl-carrier an N-terminal- a mismatched RS01580 ligase: aspS ligase: glyS ANME2D_RS04060 ANME2D_RS05045 ANME2D_RS05110 ANME2D_RS05695 ANME2D_RS06250 ANME2D_RS03710 ANME2D_RS07310 ligase: leuS ANME2D_RS07975 ANME2D_RS08530 ANME2D_RS08645 ANME2D_RS08665 ANME2D_RS09120 alaS ligase: metG ligase: metG ANME2D_RS16170 dehydrogenase: mannose-6- a polycistronic pyruvate pyruvate a ribonucleoside a single citrate MoO - agmatine ANME2D_RS02355 mcrB mcrG mcrA deoxyribonucleoside deoxyribonucleoside methoxy-mycolyl- 2 6 L-methionyl-L- [DNA] triphosphate [DNA] ATP protein]-N -[(R) ATP DNA base pair aroE methane phosphate isomerase: tRNA precursor 5'-triphosphate stranded DNA molybdopterin an L-methionyl- ANME2D_RS02360 mtrH CTP 5'-triphosphate trehalose 6- bifunctional -dihydrolipoyl]- seryl-[protein] NMN DNA an L-aspartyl- an L-valyl- an L-cysteinyl- an L-tyrosyl- an L-glutamyl- an L-tryptophanyl- an L-phenylalanyl- an L-histidyl- an L-leucyl- an L-isoleucyl- an L-lysyl- an L-prolyl- an L-threonyl- an L-arginyl- an L-alanyl- an L-methionyl- an L-seryl- an L-asparaginyl- an L-glutaminyl- ANME2D_RS07150 cofactor a glycyl-[tRNA Gly ] [elongator shikimate tetrahydromethanopterin UMP phosphate bifunctional aconitate hydratase L-lysine dihydrolipoyl mismatch [tRNA asp ] [tRNA Val ] [tRNA Cys ] [tRNA Tyr ] [tRNA Glu ] [tRNA Trp ] [tRNA Phe ] [tRNA His ] [tRNA Leu ] [tRNA Ile ] [tRNA Lys ] [tRNA Pro ] [tRNA Thr ] [tRNA Arg ] [tRNA Ala ] [initiator tRNA Met ] [tRNA ser ] [tRNA Asn ] [tRNA Gln ] F6P pyruvate ferredoxin pyruvate ferredoxin Met DNA polymerase DNA alpha,alpha- 2/2-methylisocitrate dehydrogenase: agmatinase: repair RS05100 RS13380 tRNA ] S-methyltransferase: 5'/3'- tRNA- oxidoreductase oxidoreductase group II type II methionyl shikimate kinase: II large subunit: primase trehalose-phosphate dehydratase: molybdenum cofactor lpdA nicotinamide- speB protein mtrE mtrD mtrC mtrB nucleotidase intron subunit gamma: subunit gamma: intron reverse aminopeptidase: ANME2D_RS16210 CDP ANME2D_RS03350 regulatory synthase (UDP- ANME2D_RS11055 guanylyltransferase: nucleotide MutS: mutS ANME2D_RS04135 SurE: surE lyase: ANME2D_RS10645 ANME2D_RS10645 transcriptase/ dihydrolipoyl ANME2D_RS10985 a properly endA subunit maturase: ltrA forming)/trehalose- aconitate hydratase ANME2D_RS07650 dehydrogenase: adenylyltransferase: shikimate 3- mtrF mtrG mtrH DNA-directed type II methionyl matched uridine [+ 3 isozymes] [+ 3 isozymes] PriL: priL phosphatase: AcnA: acnA a [lipoyl-carrierANME2D_RS10875 ANME2D_RS10805 putrescine urea RS16945 RS07985 Cofactor, Carrier, and Vitamin Biosynthesis phosphate DNA polymerase aminopeptidase: DNA base pair methyl-CoM trehalose- ANME2D_RS09220 adenylyl protein]-N 6 -[(R CMP a 3'-half-tRNA a 5'-half-tRNA a tRNA intron II small subunit: [+ 2 isozymes] D-threo-isocitrate ANME2D_RS04550 3-phosphoshikimate 1- a reduced trans-methoxy- molybdenum + [DNA] )-lipoyl]-L-lysine molecule with molecule with with a 2',3'-cyclic acetyl-CoA CO H ANME2D_RS04740 acetyl-CoA CO a reduced + cob(II)yrinate a,c- carboxyvinyltransferase: 5'/3'- 2 ferredoxin [iron- 2 mono-mycolate cofactor NAD [2Fe-2S] iron-sulfur factor 420 biosynthesis I (archaea) molybdopterin biosynthesis dipyrromethane menaquinol-7 biosynthesis 4-amino-2-methyl-5- S-adenosyl- a 5'-OH end a 2',3'-cyclic phosphate and flavodoxin ssDNA/pppN(pN) diamide biosynthesis I coenzyme A biosynthesis aroA methyl-coenzyme M oxidation to CO nucleotidase sulfur] cluster an N-terminal RS10370 RS12095 cluster biosynthesis cofactor biosynthesis diphosphomethylpyrimidine L-methionine 2 phosphate end a 5'-hydroxyl hybrid I (prokaryotic) 5-enolpyruvoyl- n -1 met L-seryl-[protein] (early cobalt insertion) all-trans- Carbohydrate Biosynthesis SurE: surE terminus [DNA] an apo-[hydroxymethylbilane biosynthesis I biosynthesis shikimate 3- uroporphyrinogen-III ARP (R)-4'- heptaprenyl 1,4-dihydroxy- methyl-CoM L-cysteine desulfurase ATP GTP synthase]-L-cysteine AIR phosphate cytidine uroporphyrinogen-III phosphopantothenate diphosphate 2-naphthoate met gluconeogenesis I 5-amino-6-(D- bifunctional cys phosphomethylpyrimidine PRPP biosynthesis GDP-mannose biosynthesis chorismate RS08740 C-methyltransferase: methionine a [2-oxoglutarate- a tRNA precursor 6-O-trans-keto- 1-deoxy-L- a peptide with RS13350 cysteine desulfurase: ribitylamino) phosphopantothenoylcysteine molybdopterin- synthase: + a 5,10- an N-modified a [protein]-L- GTP 3',8- synthase ThiC: thiC a sulfurated 3-methylbutanoate menadione NADH H sec 5'-deoxyadenosine cobA a [hydroxymethylbilane adenosyltransferase: D-ribose 5- SAM dehydrogenase with a 5' methylenetetrahydrofolate mycolyl-trehalose a protein glycero-tetrulose ser a tRNA an N-terminal methionine ANME2D_RS13200 uracil--L- decarboxylase/ synthase cysteine desulfurase: [+ 2 isozymes] (S)-malate D-glucopyranose aroC [sulfur carrier] aminoacyl-[tRNA] ARP dITP precorrin-1 cyclase synthase] ES intermediate ANME2D_RS14150 E2 protein] N 6 - extension and a 6-phosphate 4-phosphate L-methionine peptide- [+ 2 isozymes] tyrosine 4- phosphopantothenate-- adenylyltransferase ANME2D_RS13200 2 HMP-P phosphate 6-phosphate 5-methyl- an oxidized bifunctional bifunctional archaeal proteasome MoaA: moaA ribose-phosphate glucose-6-phosphate chorismate octanoyl-L-lysine short 3' extension methionine hydroxyphenyl cysteine ligase CoaBC: coaBC MoeB: moeB hydroxymethylbilane demethylmenaquinol-7 methionine tetrahydrosarcinapterin factor 420 5,10-methylene- alpha,alpha- endopeptidase complex XTP/dITP RS03215 uroporphyrinogen-III an S-sulfanyl-[L- (R)-4'- [+ 2 isozymes] (8S)-3',8-cyclo-7,8- malate diphosphokinase: isomerase: CO dehydrogenase/ NADH-quinone S-methyl-5'- a carboxy-adenylated an [L-cysteine synthase: hemC bifunctional adenosyltransferase: tetrahydrofolate peptidyl-tRNA trehalose-phosphate subunit alpha: psmA 6,7-dimethyl-8- type II methionyl diphosphatase: (S)-S-oxide RS11375 C-methyltransferase: cysteine desulfurase] transferase phosphopantothenoyl- dihydroguanosine ANME2D_RS10490 lipoyl acetyl-CoA synthase oxidoreductase: serine--tRNA ligase: thioadenosine [small subunit of desulfurase]-S- bifunctional hydroxymethylpyrimidine ANME2D_RS11415 dehydrogenase: ANME2D_RS05305 dehydrogenase/ hydrolase: ribityllumazine ANME2D_RS02950 reductase cobA CofH: cofH L-cysteine 5'-triphosphate a [hydroxymethylbilane PRPP complex: cdhA cdhB ribonuclease P nuoK nuoH synthase (UDP- archaeal proteasome ANME2D_RS16170 aminopeptidase: phosphorylase: SAM mdh F6P synthase: 5,10-methylene- MsrA: msrA molybdopterin synthase] sulfanyl-L-cysteine cyclic pyranopterin synthase] ES intermediate demethylmenaquinone kinase/ protein component 1: ANME2D_RS04865 forming)/trehalose- endopeptidase complex synthase: ANME2D_RS10985 a protein-L- 5-amino-5-(4- bifunctional 3 Inorganic Nutrient Metabolism lipA [+ 2 isozymes] ANME2D_RS04690 mtnP methyltransferase/2- phosphomethylpyrimidine tetrahydrofolate ANME2D_RS05685 dIMP precorrin-2 hydroxybenzyl)- phosphopantothenoylcysteine monophosphate pyruvate mannose-1-phosphate 5,10-methylene- ANME2D_RS01725 ANME2D_RS04695 phosphatase: subunit beta: psmB type II methionyl methionine- RS13510 hydroxymethylbilane methoxy-6-polyprenyl- kinase: thiD cyclohydrolase: an S-sulfanyl-[cysteine 6-(D-ribitylimino) decarboxylase/ synthase oxaloacetate guanylyltransferase/ tetrahydrosarcinapterin a [2-oxoglutarate ribonuclease P: trehalose- ANME2D_RS09220 a peptide an L-seryl- aminopeptidase: 5-deoxy-α- (S)-S-oxide RS05085 bifunctional precorrin- synthase: hemC 1,4-benzoquinol polyphosphate sulfur reduction 5'-deoxyadenosine an unsulfurated ANME2D_RS15655 an N-modified an uncharged desulfurase]-[disordered- MoaC: moaC mannose-6- nitrogen fixation met dehydrogenase 3-methylbutanoyl-CoA ANME2D_RS08890 trans-keto- [tRNA sec ] ANME2D_RS04550 2 dehydrogenase/ -5,6-dihydrouracil phosphopantothenate-- HMP-PP metabolism diphosphate a 5,10- amino acid tRNA 6,7-dimethyl-8-(1- D-ribose 1- 2-phospho- a thiocarboxylated a [hydroxymethylbilane methylase UbiE: ubiE phosphoenolpyruvate II (via polysulfide) 6 [sulfur carrier] AMP + adenine form scaffold 7,8-didemethyl- cysteine ligase CoaBC: coaBC cyclic pyranopterin phosphate isomerase: I (ferredoxin) E2 protein] N NAD menadiol mono-mycolate D-ribityl)lumazine phosphate sirohydrochlorin L-lactate [small subunit of synthase] ES intermediate synthase: ppsA methenyltetrahydrofolate protein] complex 8-hydroxy-5- 4 ANME2D_RS07150 long chain -lipoyl-L-lysine RS00275 phosphate menaquinol-7 S 0 a tRNA precursor ferrochelatase: 2-phospho-L-lactate 4'-phosphopantetheine molybdopterin synthase] demethylmenaquinol- 5,10-methenyl- N deazariboflavin hydroxymethylbilane D-mannopyranose polyphosphate 2 with a short a tRNA fragment RS12065 ANME2D_RS13245 8 biosynthesis II tetrahydrosarcinapterin met a peptide guanylyltransferase: synthase synthase: hemC phosphoenolpyruvate 6-phosphate nitrogenase 3' extension cofC phosphopantetheine molybdopterin all-trans- component I sirohydrochlorin a [cysteine desulfurase]- CofG: cofG adenylyltransferase: synthase: a holo-[hydroxymethylbilane thioredoxin phosphomannomutase: methenyltetrahydromethanopterin L-lactyl-2- 7,8-didemethyl- 1,4-dihydroxy- octaprenyl phosphopyruvate inorganic a polysulfide subunit alpha: RS04985 S-sulfanyl-[disordered- pathway UDP-N-acetyl-D- ANME2D_RS08670 cyclohydrolase: mch 6-O-cis-methoxy- ANME2D_RS08535 ANME2D_RS09115 synthase] 6-naphthoate diphosphate hydratase: 7,8-didemethyl- 3-(D-glyceryl) an [eIF5A- a 5,10- 6-O-cis-keto- β-D-glucose (3R,5S)-3- diphospho- 8-hydroxy-5- glucosamine biosynthesis I polyphosphate ANME2D_RS03690 spermidine an L-asparaginyl- carbonic acid RS01490 form scaffold 3'-dephospho- ANME2D_RS15840 α-D-mannose 5-formyl- polysulfide cob(II)alamin 8-hydroxy-5- -diphospho- mycolyl-trehalose mycolyl-trehalose tyr 6-phosphate hydroxy-1- 5'-guanosine deazariboflavin molybdenum an oxidized a methanofuran kinase: ammonium ATP precursor]-lysine GTP methenyltetrahydrofolate [tRNA Asn ] ATP XTP protein] complex menaquinone D-glucopyranose 1-phosphate tetrahydrosarcinapterin reductase NrfD: deazariboflavin 5'-guanosine bifunctional 6-phosphate 6-phosphate inositol-3-phosphate biotin pyrroline-5- cysteine desulfurase: CoA molybdopterin cofactor biosynthesis ANME2D_RS02855 bifunctional bifunctional cobalt- thioredoxin 2-phospho-D-glycerate ANME2D_RS12515 synthase: 2-phospho-L- biosynthesis 6-phosphate mannose-1-phosphate 5,10-methylene- alpha,alpha- XTP/dITP carboxylatepyrroline-5- RS16610 ANME2D_RS13200 glucose-6-phosphate formylmethanofuran-- deoxyhypusine alpha,alpha- ANME2D_RS00395 carbonate sirohydrochlorin lactate transferase: molybdopterin pyridoxal 5'-phosphate biosynthesis II decarboxylase: [+ 3 isozymes] 2-phospho-L- tetrahydrofolate trehalose-phosphate peptidyl-tRNA diphosphatase: carboxylate [+ 2 isozymes] molybdate cofactor-independent isomerase: guanylyltransferase/ tetrahydromethanopterin cob(I)yrinic acid synthase: trehalose-phosphate tyrosine phenol-lyase: dehydratase: an S-sulfanyl-[cysteine ANME2D_RS09765 ANME2D_RS11385 long chain lactate transferase: GTP cyclohydrolase dehydrogenase/ hydrolase: inositol-3-phosphate biotin--[acetyl-CoA- ANME2D_RS02950 reductase: RS02000 thioredoxin- phosphoglycerate ANME2D_RS05305 mannose-6- a polysulfide a,c-diamide ANME2D_RS15050 synthase (UDP- synthase (UDP- ANME2D_RS14830 ANME2D_RS11480 desulfurase]-S- N-formyltransferase: fhcD polyphosphate I FolE2: 5,10-methylene- ANME2D_RS04865 synthase: carboxylase] ligase: proC coenzyme A disulfide mutase: F6P phosphate isomerase: adenosyltransferase: ANME2D_RS09765 forming)/trehalose- forming)/trehalose- sulfanyl-[disordered- oxidized aldehydo-D-ribose D-glyceraldehyde gln deoxyhypusine ANME2D_RS06390 tetrahydrofolate ANME2D_RS02315 ANME2D_RS16575 XMP Hyp RS08895 bis(guanylyl molybdopterin) reductase: demethylmenaquinol-8 ANME2D_RS07160 ANME2D_RS07150 ANME2D_RS13775 phosphatase: phosphatase: 5-phosphate 3-phosphate synthase: cyclohydrolase: cobalt-factor III form scaffold factor 420-0 cofactor sulfurylation molybdopterin glutamine-- GDP-α-D- a formylmethanofuran ANME2D_RS09220 ANME2D_RS09220 Ins(3)P CO H O trxB 2,3-bisphosphoglycerate- oxidized 3PG- trehalose- 2 2 adenine ANME2D_RS01615 7,8- ANME2D_RS15655 phenol pyruvate Asn RS01990 protein] complex molybdate fructose-6- mannose trehalose-cis-keto- asn tRNA biotinyl-5'- independent adenosylcobalamin factor 420-0 GMP formate 10 cis-methoxy- dinucleotide pyridoxal 5'- menaquinol-8 biosynthesis phosphate formylmethanofuran triphosphate dihydroneopterin an N - mono-mycolate cys phosphoglycerate Amino Acid Degradation mono-mycolate adenylate RS00255 phosphate transaminase dehydrogenase: propane- an [eIF5A- 3'-triphosphate formyltetrahydrofolate a reduced mutase: an oxidized molybdopterin synthase (isomerizing) ANME2D_RS07900 1,3-diamine precursor]- a [cysteine coenzyme B/coenzyme M regeneration cysteine desulfurase: thioredoxin demethylmenaquinol-8 ANME2D_RS00355 L-histidine degradation I cobalt-precorrin-3 factor 420 molybdotransferase glutaminase hydroxymethylpyrimidine 4-aminobenzoate deoxyhypusine desulfurase]-(S- I (methanophenazine-dependent) ANME2D_RS13200 bifunctional : glmS [+ 3 isozymes] L-methionine degradation L-glutamine RS12020 F420-dependent MoeA: subunit salvage biosynthesis sulfanyl) -[disordered- [+ 2 isozymes] demethylmenaquinone 3-phospho-D-glycerate D-glucosamine I (to L-homocysteine) degradation II 2 methylenetetrahydromethanopterin PdxT: pdxT CO RS15450 H an [L-cysteine ANME2D_RS16230 2 7,8-didemethyl- enolpyruvoyl- 6-O-α-mycolyl- 3''-O-acetyl- form scaffold 2 methyltransferase/2- 6-phosphate his a [DNA]-3'- + a 5'-phospho- a ribonucleoside D-glucopyranose a supercoiled a lipoprotein dehydrogenase: ANME2D_RS07860 4-amino-2-methyl-5- chorismate NAD isobutanoate H O a nucleoside acetyl-CoA butanoyl-CoA desulfurase]-S- molybdopterin pyridoxal 5'- 8-hydroxy-5- 2-diphospho- 2 6-phosphate trehalose 6- ADP-ribose signal peptide protein] complex pyrimidinemethanol methoxy-6-polyprenyl- phosphoglycerate phosphoglucosamine histidine met gln hydroxyl [DNA] GTP triphosphate RNA diphosphate duplex DNA AMP ITP a reduced phosphate bifunctional aminodeoxychorismate/ deazariboflavin 5'-guanosine inositol-3-phosphate phosphate ATP-dependent signal cobalt-precorrin-4 sulfanyl-L-cysteine molybdotransferase 1,4-benzoquinol kinase: pgk ammonia- methionine adenosylcobalamin- bifunctional sulfite FtsY bis(guanylyl hydroxymethylpyrimidine anthranilate synthase mutase: glmM NADPH- synthase: peptide factor 420 cysteine desulfurase: MoeA: synthase methylase UbiE: ubiE lyase: hutH adenosyltransferase: dependent O-acetyl-ADP- DNA helicase: XTP/dITP molybdopterin) kinase/ component II: α-D-glucosamine dependent ATP-dependent CO dehydrogenase/ acetyl-CoA C- ANME2D_RS00395 alpha,alpha- RS16455 ANME2D_RS13200 ANME2D_RS01925 lyase subunit 13-DPG 2-oxoisovalerate decarboxylation to isobutanoyl-CoA urocanate 2-phospho-L- DNA-directed RNA ribonucleoside- ribose deacetylase: ANME2D_RS08055 diphosphatase: peptidase a reduced cofactor menaquinol-8 ANME2D_RS14150 glutamate DNA ligase: acetyl-CoA synthase GTPase: acetyltransferase: trehalose-phosphate a [cysteine desulfurase]- [+ 2 isozymes] PdxS: pdxS phosphomethylpyrimidine ANME2D_RS09300 1-phosphate lactate transferase: polymerase subunit L: diphosphate inositol-3-phosphate ATP-dependent phosphoadenylyl- SppA: sppA adenosylcobalamin factor 420 4-amino-4- methionine synthase: ANME2D_RS01830 ANME2D_RS07835 synthase (UDP- ANME2D_RS00570 ANME2D_RS02950 [scaffold protein- a [bis(guanylyl MoO - kinase: thiD glucosamine- an [apo BCAA urocanate complex: cdhA cdhB ANME2D_RS03095 sulfate reductase: 2 deoxychorismate type II glyceraldehyde- ANME2D_RS09765 ANME2D_RS12895 reductase: synthase: DNA helicase: a peptide RS15470 cobalt- salvage from cobalamin hydratase: adenosyltransferase: gltA [+ 2 isozymes] [+ 2 isozymes] [+ 2 isozymes] forming)/trehalose- (2Fe-2S)] complex molybdopterin) molybdopterin HMP-P triose- 3-phosphate 1-phosphate dehydrogenase [+ 7 isozymes] ANME2D_RS05920 ANME2D_RS02315 ANME2D_RS01335 ANME2D_RS07995 IMP precorrin-5A F420H2 H 6 ANME2D_RS11415 glu a 2'- phosphatase: RS01410 2 cofactor [bis-MGD cofactor cofactor PLP acetyltransferase: E2 protein] N hutU ADP-D-ribose a single cob(I)alamin dehydrogenase phosphate dehydrogenase: alpha-ketoacid acetate cobalt- bifunctional SAM [DNA] NMN dehydro + deoxyribonucleoside Ins(3)P ANME2D_RS09220 coenzyme M chaperone]-S- chaperone]- isomerase: ANME2D_RS04075 ANME2D_RS01140 dTDP-β-L-rhamnose -lipoyl-L-lysine dehydrogenase 4-imidazolone- AMP phosphate H 3-oxohexanoyl- α, α'-trehalose stranded DNA subunit FpoO: hydroxymethylpyrimidine factor 420-0 isobutanoyl-CoA GDP 5'-diphosphate precorrin 5A biosynthesis II sulfanyl-L-cysteine bis-MGD N-acetyl-α-D- biosynthesis dihydrolipoyl 5-propanoate GMP diphosphate RNA α APS a [co-chaperone]- ANME2D_RS04645 4-aminobenzoate tpiA D-glyceraldehyde subunit beta: AMP CoA 6- -mycolate RS06135 hydrolase: kinase/ DHAP glucosamine dehydrogenase: [scaffold protein- 3-phosphate α-D-glucopyranose ANME2D_RS14025 imidazolonepropionase: RS17160 cbiG O-phospho- cob(II)alamin phosphomethylpyrimidine 1-phosphate ANME2D_RS10875 (2Fe-2S)] complex CoB-CoM 1-phosphate ANME2D_RS09360 cobalt- L-serine dihydromethanophenazine 5-methylbenzimidazolyl kinase: thiD dihydrolipoyl cob(I)yrinic acid heterodisulfide N-acetylglucosamine- glucose-1-phosphate precorrin-5B cysteate synthase: sulfo-bis(guanylyl adenosylcobamide biosynthesis dehydrogenase: N-formimino- SAH a DNA containing 2''-O-acetyl- a,c-diamide HMP-PP 1-phosphate thymidylyltransferase: a CDP- a [ThiI sulfur- α,α-trehalose ANME2D_RS16345 molybdopterin) an [apo BCAA MoO - a uracil in tRNA carbamoyl coenzyme A pimelate a RNA-DNA hybrid an L-glutamyl- DHAP 2-iminosuccinate an unfolded RS04935 cobalt-precorrin- from adenosylcobinamide-GDP uridyltransferase: lpdA L-glutamate ser 2 carrier protein]- an apurinic/ L-ornithine asp O-ureido-L- ADP-ribose adenosyltransferase: CoB--CoM ANME2D_RS12070 an [apo BCAA dehydrogenase diacylglycerol GTP 6-phosphate Gln GTP RS08245 a [chaperone-ATP]- L-cysteate cofactor α dehydrogenase NADH repair (prokaryotes) molybdopterin phosphate [tRNA ] protein 5B (C(1))- ANME2D_RS01140 dTDP- -D-glucose 6 adenosylhomocysteinase: molybdopterin S-sulfanyl- apyrimidinic site homoserine bifunctional [co-chaperone]- ANME2D_RS13775 heterodisulfide 5-methylbenzimidazole 6 E2 protein] N -S-[2- formimidoylglutamase: Asp-tRNA(Asn) methyltransferase: cytidylyl molybdenum UDP-N-acetyl- E2 protein] N ANME2D_RS13900 cofactor L-cysteine alpha,alpha- anaerobic [scaffold protein- cob(II)alamin- reductase: dTDP-glucose 4,6- methylpropanoyl]dihydrolipoyl- ANME2D_RS09350 6-carboxyhexanoate- O-acetyl-ADP- /Glu-tRNA(Gln) quinolinate chaperonin ANME2D_RS02080 cofactor sulfurylation α-D-glucosamine -dihydrolipoyl- NADH ribonuclease HII: trehalose-phosphate ribonucleoside- [corrinoid hdrB hdrC dehydratase: rfbB L-lysine CDP-diacylglycerol--serine endonuclease ornithine argininosuccinate ribose deacetylase: amidotransferase: synthase GroEL: groL (2Fe-2S)] complex L-lysine molybdenum cofactor tRNA 4- -CoA ligase: ANME2D_RS05780 triphosphate RS00450 cobalt- β dTDP-4-dehydro-6- L-homocysteine O-phosphatidyltransferase: III: nth carbamoyltransferase: synthase: synthase (UDP- ANME2D_RS00570 gatC gatA gatB RS16110 adenosyltranferase] 5-methylbenzimidazole factor 420 cytidylyl molybdenum -D-fructose 1,6- glu thiouridine(8) ANME2D_RS09055 NadA: nadA reductase: nrdD α pssA guanylyltransferase: argF ANME2D_RS05565 forming)/trehalose- precorrin-6A 3-sulfopyruvate phosphopantothenate ribotide phosphate cofactor (trioxo) bisphosphate deoxy- -D-glucopyranose endonuclease III: [+ 2 isozymes] a protein coenzyme M coenzyme B adeninyl adenosylcobamide polyglutamylation ANME2D_RS07650 synthase phosphatase: an L-glutaminyl- dGTP biosynthesis III adenosylcobinamide- fructose 1,6- dTDP-4- ANME2D_RS14430 sulfopyruvate ThiI: thiI a nucleoside 5'- ANME2D_RS09220 ADP-D-ribose Gln a [chaperone- biosynthesis from oxidized dehydrorhamnose 2-oxo acid a 3-sn- pimeloyl-CoA DNA acetate [tRNA ] quinolinate cob(I)alamin- (archaebacteria) GDP an [MCD cofactor bisphosphatase: CMP monophosphate an [2Fe-2S] decarboxylase adenosylcobinamide-GDP factor 420-0 dehydrogenase (R)-NADHX phosphatidyl- bis(guanylyl canavaninosuccinate α,α-trehalose PhnD RS03040 ADP]-[disordered- [corrinoid 3-methyl-2- ribazoletransferase: coenzyme chaperone]-MCD ANME2D_RS04285 3,5-epimerase: a [ThiI sulfur- a 4-thiouracil a 3'-terminal a 5'-phospho- L-citrulline cobalt- cluster protein subunit subunit E2: bifunctional ADP- glycine cleavage L-serine molybdopterin) form scaffold adenosyltranferase] oxobutanoate cobS F420-0:L- ANME2D_RS12075 carrier protein]- in tRNA unsaturated sugar [DNA] precorrin-6B beta: comE adenine cysteine desulfurase: ANME2D_RS14020 dependent NAD(P)H- cofactor protein] complex cob(I)yrinic acid Coα-[α-(5- F6P dTDP-4-dehydro- a [glycine-cleavage L-cysteine adenosylcobalamin glutamate ANME2D_RS13200 a,c-diamide methylbenzimidazolyl)]- β-L-rhamnose hydrate dehydratase/ 6 sulfoacetaldehyde ligase: cofE [+ 2 isozymes] glucose-6-phosphate complex H protein] N RS16275 biosynthesis from 2-dehydropantoate β NAD(P)H-hydrate glycine cleavage adenosyltransferase: Co -adenosylcobamide dTDP-4- -[(R)-lipoyl]-L-lysine a [glycine-cleavage 34 RS01355 adenosylcobinamide-GDP I thiamine diphosphate coenzyme F420-0:L- a [cytidylyl molybdenum isomerase: system protein H: a 2-oxo 5,10-methylene- an epoxyqueuosine a [DNA]-3'- a 5'-phospho- a [histone]-N 6 - a [protein]-L- 7-carboxy-7- ANME2D_RS13775 5'-phosphate dehydrorhamnose epimerase: complex H protein] a peptide with a futalosine 3',5'-ADP cobalt-precorrin-7 an [Fe-S cluster adenine ribotide biosynthesis glutamate ligase: cofactor chaperone]- ANME2D_RS05305 ANME2D_RS05705 a sulfurated [sulfur carrier] SAM carboxylate tetrahydromethanopterin in tRNA hydroxyl [DNA] acetyl-L-lysine sulfite asp β-isoaspartate met deazaguanine lys adenosylcob(III) 5,6-dimethylbenzimidazole alpha-ribazole ANME2D_RS01565 glycine cleavage 6 leader sequence biosynthesis phosphate ANME2D_RS03845 cytidylyl molybdenum reductase: rfbD (S)-NADHX N -octanoyl-L-lysine epoxyqueuosine asparagine protein-L- 7-cyano-7- alamin-[corrinoid phosphatase II (Bacillus) oxidized D-glucopyranose Glycolysis system protein H: glycine cleavage bifunctional lysine 2,3- chaperone]-ATP 2-(sulfomethyl) cofactor (sulfo-dioxo) β reductase QueH: isoaspartate(D- deazaguanine RS15435 cobalt-precorrin- adenosyltranferase] CobZ: cobZ 6-phosphate dTDP- -L-rhamnose system protein futalosine ATP-dependent synthase (glutamine- ornithine thiazolidine- adenosylcobinamide- HMP-PP factor 420-1 bifunctional ADP- ANME2D_RS05705 2-oxoacid:ferredoxin bifunctional 5,6,7,8- ANME2D_RS04850 histone deacetylase: phosphoadenylyl- aspartate) O- synthase aminomutase: 7 (C(5))- α (R)-pantoate Coα-[α-(5- signal peptidase I: hydrolyzing): asnB acetyltransferase/ RS00760 4-carboxylate cob(I)yrinic acid -ribazole GDP glycolysis I (from glucose 6-phosphate) dependent NAD(P)H- [+ 3 isozymes] H: gcvH lipoyl oxidoreductase tetrahydromethanopterin hydrolase: DNA ligase: sulfate reductase: ablA methyltransferase: ANME2D_RS17080 epoxyqueuosine ANME2D_RS02475 methyltransferase: N-acetylglutamate QueC: queC a,c-diamide 5'-phosphate methylbenzimidazolyl)]- hydrate dehydratase/ synthase: lipA subunit beta: hydro-lyase/3-hexulose- mqnB ANME2D_RS01830 asparagine synthetase ANME2D_RS02075 ribazoletransferase: β bis(guanylyl tungstenpterin) a [glycine-cleavage reductase: ANME2D_RS07995 ANME2D_RS15555 preQ L-β-lysine Co -adenosylcobamide a [glycine-cleavage [+ 2 isozymes] B: ANME2D_RS07300 a protein L-β- synthase: argJ 0 adenosyltransferase: adenosylcobinamide- cobS thiamine cofactor biosynthesis D-glucopyranose NAD(P)H-hydrate complex H protein] N 6 - ANME2D_RS01280 6-phosphate synthase: Coα-[α-(adenin- oxidized complex H protein] N 6 ANME2D_RS05855 N-acetyl-L- 2+ 2+ RS14740 cobalt-precorrin-8 ANME2D_RS13775 phosphate 6-phosphate epimerase: ANME2D_RS14785 34 asn isoaspartate Zn RS09390 Zn GDP β aminomethyldihydrolipoyl- a [glycine-cleavage dehypoxanthine a queuosine acetate methionine (R)-4- 9-yl)]-Co - factor 420-2 ANME2D_RS01565 -dihydrolipoyl-L-lysine [DNA] a [histone]-L-lysine α-methyl ester ribazoletransferase: thiamine- L-lysine 5'-deoxyadenosine 6 an unsulfurated a reduced futalosine in tRNA PAPS sulfoethylcysteine adenosylcobalamin adenosylcobamide met complex H protein] N + hypoxanthine phosphopantoate bis(tungstenpterin) GTP glucose-6-phosphate [sulfur carrier] an acyl-CoA CO H a leader sequence a peptide Zn 2+ RS11980 Zn 2+ cobS monophosphate -[(R)-lipoyl]-L-lysine 2 ferredoxin [iron- 5'-phosphate isomerase: NADH formaldehyde THMPT phosphopantothenate/ kinase: cofactor Tetrapyrrole Biosynthesis sulfur] cluster RS06005 adenosylcobalamin alpha-ribazole ANME2D_RS05305 pantothenate ANME2D_RS11835 heme b CcmA heme b cobyrinate 5'-phosphate phosphatase molybdenum cofactor glycine cleavage synthetase: thiamine- L-citrulline degradation alpha-ribazole CobZ: cobZ factor 430 biosynthesis system protein H: ANME2D_RS13190 Coα-[α-(adenin- guanylyltransferase: tetrapyrrole biosynthesis siroheme biosynthesis F6P a [pyruvate dehydrogenase E2 a pseudouridine 54 6,7-dimethyl-8-(1- an [amino-group carrier succinate D-ribose 5- coenzyme M phosphate Fatty Acid and Lipid Biosynthesis ANME2D_RS05705 succinate canavaninosuccinate hydrogenobyrinate DNA with lesion CAIR Na + RS02230 Na + phosphatase ANME2D_RS07650 a sulfurated [sulfur carrier] 6 ala a pimeloyl-[acp] protein]-C-terminal-γ- (R)-4'- 7-yl)]-Coβ- kinase: thiL I (from glutamate) Pentose Phosphate Pathways SAM protein] N -octanoyl-L-lysine ATP ATP in tRNA D-ribityl)lumazine semialdehyde phosphate RS11515 CobZ: cobZ glycine cleavage L-citrulline (L-glutamyl)-L-glutamate excinuclease ribose-5- phosphopantothenate adenosylcobamide uroporphyrinogen-III fructose 1,6- ammonium hydrogencarbonate selenate tRNA hydrogenobyrinic NAD-dependent 5-(carboxyamino) CDP-archaeol biosynthesis uroporphyrinogen-III + Na + cob(II)yrinate thiamine bis(guanylyl biotin-carboxyl carrier uroporphyrinogen-III system protein ornithine (pseudouridine(54) acid a,c-diamide acetylglutamate succinate- ABC subunit imidazole phosphate Na RS16585 adenosylcobalamin glu uroporphyrinogen-III bisphosphatase: pentose phosphate pathway ADP-forming a,c-diamide diphosphate tungstenpterin) cofactor protein assembly C-methyltransferase: H: gcvH carbamoyltransferase: 8-amino-7- -N(1))- argininosuccinate riboflavin synthase: synthase kinase: argB semialdehyde UvrB: uvrB ribonucleotide isomerase glutamate-- C-methyltransferase: ANME2D_RS04285 (oxidative branch) II succinate--CoA DHAP cobA DHAP argF lipoyl synthase: lipA oxononanoate methyltransferase lyase: argH ANME2D_RS01535 (glutamine- dehydrogenase: excinuclease mutase: purE RpiA: rpiA Cd 2+ CadA Cd 2+ a [biotin carboxyl- tRNA ligase: cobA carbamoyl carbamate ligase: sucD sucC sulfate an [amino-group carrier D-ribulose RS05220 precorrin-1 β-D-fructose 1,6- TrmY: trmY hydrolyzing): cobB ANME2D_RS10925 F6P phosphate synthase: bioF kinase: arcC adenylyltransferase: sat an N 1 - protein]-C-terminal- ABC: uvrC uvrA AIR carrier protein]-L-lysine an L-glutamyl-ANME2D_RS05695 precorrin-1 hydrogenobyrinate DNA without 5-phosphate bisphosphate 54 γ-(5-phospho-L- succinate 2+ 2+ NAD(P)-dependent uroporphyrinogen-III Glu methylpseudouridine Mg MgtA Mg biotin--[acetyl-CoA- [tRNA ] triose- L-threonine carbamoyl- a,c-diamide lesion C-methyltransferase: uroporphyrinogen-III 6-phospho-3- a [pyruvate dehydrogenase (8S)-8-amino-7- phosphate succinyl-CoA in tRNA L-canavanine fumarate ARP riboflavin glutamyl)-L-glutamate glycerol-1-phosphate carboxylase] ligase: degradation II phosphate 5'-deoxyadenosine adenosine 5'- glutamyl-tRNA C-methyltransferase: phosphate hexuloisomerase: hxlB met 6 an unsulfurated [sulfur carrier] acyl-carrier protein carbamoyl ADP RS05490 dehydrogenase: ANME2D_RS16575 cobA synthase E2 protein] N -lipoyl-L-lysine oxononanoate cobA isomerase: phosphate phosphoselenate ANME2D_RS03295 GGPP a [biotin carboxyl- reductase: PhnD L-histidine biosynthesis Amino Acid Biosynthesis tpiA thr large L-arginine biosynthesis I (via L-ornithine) L-tryptophan biosynthesis L-leucine biosynthesis carrier protein]-N precorrin-2 ANME2D_RS13240 hexulose 6-phosphate L-valine biosynthesis precorrin-2 L-threonine 3- subunit: carB L-tyrosine biosynthesis I 6 -biotinyl-L-lysine (S)-4-amino-5- PRPP 3-methyl-2- sn-glycerol bifunctional precorrin- dehydrogenase: [+ 2 isozymes] a reduced (1S,2R)-1- a tRNA a negatively (2R,3S)-2- (2R,3S)-3- RS17185 oxopentanoate D-glyceraldehyde a sulfurated an oxidized (2E,6E)-farnesyl 0 gln 1-phosphate 2 dehydrogenase/ bifunctional precorrin- ANME2D_RS00330 dethiobiotin IPP Hg glu oxobutanoate bifunctional hexulose- SAM H + ferredoxin [iron- ser C-(indol-3- precursor with supercoiled DNA arg methylisocitrate isopropylmalate tyr 2-isopropylmalate pyruvate glutamate-1- 2 dehydrogenase/ 3-phosphate L-2-amino-3- carbamate [sulfur carrier] thioredoxin diphosphate ATP GTP ATP ATP chorismate sirohydrochlorin 6-phosphate synthase/ sulfur] cluster yl)glycerol a 5' extension DNA topoisomerase: bifunctional 3-isopropylmalate mercury(II) RS00185 synthase: acetolactate synthase: semialdehyde sirohydrochlorin oxobutanoate arginine decarboxylase, tyrosine phosphoribosyltransferase: bifunctional chorismate mutase: anthranilate a [biotin carboxyl- ferrochelatase: type II glyceraldehyde- ribonuclease regulator: 3-phosphate sulfate adenylyltransferase ANME2D_RS07215 aconitate hydratase dehydratase adenylate/guanylate adenylate/guanylate reductase: ANME2D_RS06360 ferrochelatase: pyruvoyl-dependent: ANME2D_RS04845 ornithine ANME2D_RS16215 synthase ANME2D_RS15900 carrier-protein dimer]- ANME2D_RS13245 2,1- glycine C- L-alanine biotin di-trans,poly-cis- subunit 2: cysD ANME2D_RS07220 2/2-methylisocitrate small subunit: cyclase domain- cyclase domain- decarboxylase RS16355 ilvN 3-phosphate ANME2D_RS04830 ferredoxin:thioredoxin ANME2D_RS12345 merA 6 aminomutase: ANME2D_RS13245 acetyltransferase: degradation IV tryptophan ribonuclease P: MfnA: mfnA acetyltransferase/ prephenate component (2S)-2- [+ 2 isozymes] N -biotinyl-L-lysine dehydrogenase: synthase reductase: decaprenylcistransferase: sulfate DNA topoisomerase dehydratase: ANME2D_RS08820 containing protein: containing protein: β bifunctional 5,6,7,8- ANME2D_RS08890 biosynthetic arginine 2+ 1-(5-phospho- -D-ribosyl)-ATP N-acetylglutamate acetolactate synthase sirohydrochlorin hemL ANME2D_RS08000 synthase: trpB uppS ANME2D_RS11055 ANME2D_RS11700 ANME2D_RS11700 p-tyramine Hg I: trpE isopropylmalate GGGP acetyl-CoA sirohydrochlorin ANME2D_RS04075 tetrahydromethanopterin CO BioB: bioB ANME2D_RS00520 adenylyltransferase: sat I: ANME2D_RS09025 [+ 3 isozymes] RS17165 prephenate large subunit: 2 ANME2D_RS15365 decarboxylase: speA cis-2- (2S)-2- cyclic-GMP cyclic-AMP synthase: argJ carboxylase biotin sirohydrochlorin ala APS a relaxed DNA dehydrogenase: anthranilate PRPP 3-isopropylmalate ANME2D_RS10920 5-aminolevulinate hydro-lyase/3-hexulose- gly agmatine methylaconitate carboxylase subunit: bifunctional precorrin- alanine di-trans,octa-cis isopropylmalate RS07820 N-acetyl-L- dehydratase (S)-2-acetolactate nickelochelatase: 13-DPG 6-phosphate synthase: biotin 5'-deoxyadenosine an unsulfurated an oxidized D-glyceraldehyde an uncharged ANME2D_RS01625 ANME2D_RS16580 2 dehydrogenase/ dehydrogenase: met a reduced a tRNA fragment glutamate small subunit: cfbA porphobilinogen ANME2D_RS14785 [sulfur carrier] ferredoxin [iron- 3-phosphate trp -undecaprenyl tRNA 3-(4- a [carboxyl-carrier sirohydrochlorin thioredoxin 1-(5-phospho-β-D-ribosyl)-AMP anthranilate ANME2D_RS07440 ketol-acid 2,3-bis-O- synthase: hemB ANME2D_RS14405 sulfur] cluster diphosphate RS04070 hydroxyphenyl) L-lysine biosynthesis VI protein dimer]-N 6 - pyruvate acetylglutamate phosphoribosyltransferase: trpD reductoisomerase: (geranylgeranyl) Ni-sirohydrochlorin ferrochelatase: phosphoglycerate pyruvate [+ 3 isozymes] carboxybiotinyl-L-lysine RS01475 phosphoribosyl-AMP kinase: argB ilvC -sn-glycerol porphobilinogen ANME2D_RS13245 kinase: pgk formaldehyde D-ribulose 5-phosphate C1 Compound Utilization and Assimilation Ni-sirohydrochlorin an O 4 - an N-terminal L- an [RNA]-3'- di-trans,octa-cis cyclohydrolase: hisI N-(5-phosphoribosyl) 2-isopropylmaleate (2R)-2,3- 1-phosphate a [protein]- a double a ribonucleoside CTP N-acetylglutamyl- asp a,c-diamide siroheme a tetrahydrofolate pimeloyl-CoA 5-MTR-1-P -undecaprenyl histidinol IPP β -anthranilate dihydroxy-3- hydroxymethylbilane ser L-cysteine methylthymine DL-allothreonine a tRNA precursor ala alanyl-[S18 protein stranded DNA ribonucleoside- 1-(5-phospho- -D-ribosyl)- phosphate synthase: cfbB 3-phospho- reductive acetyl coenzyme A pathway II (autotrophic methanogens) 5'-monophosphate dCTP RS01945 aspartate kinase: 3-isopropylmalate methylbutanoate synthase: hemC in DNA of 30S ribosome] DNA topoisomerase: S-methyl-5-thioribose- 2',3'- diphosphate histidinol type 2 isopentenyl- 5-[(5-phosphoribosylamino) phosphoribosylanthranilate CDP-2,3-bis-(O- ribosomal protein undecaprenyl- 5'/3'- deaminase: tyr ANME2D_RS00225 Ni-sirohydrochlorin D-glycerate ANME2D_RS07215 1-phosphate cyclophosphate dehydrogenase: hisD RS06315 methylideneamino]imidazole- N-acetyl-gamma- dehydratase dihydroxy-acid geranylgeranyl)-sn- S18-alanine N- RNA 2',3'-cyclic diphosphate diphosphate nucleotidase dcd L-aspartyl- isomerase: ANME2D_RS09310 a,c-diamide CO ANME2D_RS07220 hydrogencarbonate glutamyl-phosphate small subunit: dehydratase: glycerol synthase: 2,3-bis-O- preuroporphyrinogen 2 serine methylated-DNA-- serine 8-amino-7- acetyltransferase: isomerase: phosphatase: histidinol Delta-isomerase: 4-carboxamide 1-(2- cofactor-independent ribonuclease Z: phosphodiesterase: SurE: surE UTP reductase: 4-phosphate ANME2D_RS07440 NADPH repair (prokaryotes) [protein]-cysteine S- oxononanoate DNA: gyrA ANME2D_RS04620 dehydrogenase: hisD ANME2D_RS01170 1-(5-phosphoribosyl)-5- ilvD ANME2D_RS07935 phytanyl-sn Ni-sirohydrochlorin phosphoglycerate formylmethanofuran hydroxymethyltransferase: hydroxymethyltransferase: ANME2D_RS01460 an N-terminal N-acetyl-ANME2D_RS03605 S-methyl-5- thpR di-trans,octa-cisANME2D_RS07500 carbamoyl- carboxyphenylamino) uroporphyrinogen- heme b biosynthesis methyltransferase: ANME2D_RS01120 an [RNA]-3'- a ribonucleoside RS15455 [(5- phosphoribosylamino) ANME2D_RS15420 L-arginine biosynthesis II (acetyl cycle) aspartate- [+ 3 isozymes] 3-methyl-2- -glycerol 1- a,c-diamide dehydrogenase: ANME2D_RS15660 ANME2D_RS15660 synthase: bioF L-alanyl-[S18 protein thio-D-ribulose -undecaprenyl his DMAPP phosphate N-acetyl-L- -1-deoxy-D-ribulose III synthase: III (from siroheme) mutase: ANME2D_RS14090 a negatively ribunucleoside- RS07875 methylideneamino]imidazole- semialdehyde (2R,3S)-3- oxobutanoate unsaturated phosphate reductive cyclase ANME2D_RS07160 NADPH ANME2D_RS07900 of 30S ribosome] 1-phosphate phosphate synthase glutamate 5- 5-phosphate ANME2D_RS05535 a 5,10- supercoiled DNA 2'-phosphate 4- carboxamide isomerase: dehydrogenase: isopropylmalate CDP-archaeol CDP-2,3-bis-(O- ATP-dependent a single-stranded large semialdehyde N-acetylglutamyl-phosphate indole-3-glycerol- branched-chain- uroporphyrinogen- siroheme 2,3-bisphosphoglycerate- [+ 3 isozymes] gly methylenetetrahydrofolate (8S)-8-amino-7- asd geranylgeranyl)-sn- reductase a [protein]-S- acetaldehyde mature tRNA oligoribonucleotide coenzyme A ANME2D_RS10800 subunit: carB acetylornithine N-acetyl-gamma- phosphate synthase: amino-acid independent a thymine in DNA gly oxononanoate L-isoleucine biosynthesis IV glycerol synthase: subunit: cfbC III synthase: a formylmethanofuran THMPT methyl-L-cysteine RS03150 phosphoribulosylformimino- transaminase: glutamyl-phosphate L-aspartate 4- ANME2D_RS15355 transaminase: ANME2D_RS04770 phosphoglycerate RS06140 glutamine- ANME2D_RS07935 12,18- AICAR-phosphate ANME2D_RS03525 reductase: semialdehyde ilvE Ni-sirohydrochlorin mutase: hydrolyzing (1S,2R)-1-C-(indol-3- (2S)-2-isopropyl- propanoate bifunctional ANME2D_RS15420 saturated a,c-diamide uroporphyrinogen-III didecarboxysiroheme (R)-NADPHX 6 α α carbamoyl- 4-hydroxy- yl)glycerol 3-phosphate 3-oxosuccinate ANME2D_RS00355 bifunctional ADP- formylmethanofuran-- a [protein]- an O - arsenic D-glyceraldehyde S-(hydroxymethyl) D-glyceraldehyde 5-deoxy- - DNA containing GDP- -D- N-acetyl-L- val CDP-archaeol reductive fluoride H O an L-aspartyl- ornithine 12,18- tetrahydromethanopterin SAM diphosphate 2 methylguanine β-alanine L-threonine 3- D-ribose 1- mannose imidazole glycerol phosphate ornithine tetrahydrodipicolinate tryptophan dependent NAD(P)H- L-cysteine (R)-pantoate triglutathione 3-phosphate glutathione 3-phosphate [tRNA Asn ] a recognition site RS16660 acetyltransferase/ cyclase: cfbC cfbD didecarboxysiroheme 2-phospho- hydrate dehydratase/ N-formyltransferase: fhcD in DNA type II glyceraldehyde- glutathione- (5-formylfuran-3-yl) O-phosphate phosphate methyl-coenzyme GDP- RS00260 phosphate synthase synthase acetylglutamate synthase: synthase: trpB S-methyl-5-thioribose- Asp-tRNA(Asn) N-acetylglutamate propanoyl-CoA 15,17 3 -seco- deacetylase: ahbC D-glycerate 3-phosphate dependent methyl phosphate threonine-phosphate M reductase mannose 4,6- subunit HisF: hisF small ANME2D_RS04470 ANME2D_RS15365 NAD(P)H-hydrate 1-phosphate /Glu-tRNA(Gln) kinase: argB 3 arsenite dehydratase: synthase: argJ (2S,4S)-4- 4-methyl-2- F430-17 -acid Fe- epimerase: SAM-dependent sodium-translocating methylated-DNA-- phosphopantothenate/ dehydrogenase: formaldehyde synthase: decarboxylase: isomerase: amidotransferase: I operon imidazole glycerol subunit: carA N-acetyl-L-glutamate 2-oxoacid:ferredoxin phosphopyruvate 5-formyl-tetrahydromethanopterin methyltransferase: glu gln N-acetyl-L-glutamate hydroxy-2,3,4,5- ser oxopentanoate coproporphyrin III chlorinase/fluorinase: pyrophosphatase: [protein]-cysteine S- ANME2D_RS04075 dehydrogenase: ANME2D_RS04520 ANME2D_RS03940 protein C: mcrC gmd phosphate synthase 5-semialdehyde indole coenzyme ANME2D_RS01565 pantothenate synthetase: arsM (R)-1-amino- 5-deoxy-D- ANME2D_RS04620 gatC gatA gatB GDP-4-dehydro- carbamoyl oxidoreductase hydratase: ANME2D_RS05865 ANME2D_RS02230 (5-formylfuran-3-yl) an L-asparaginyl- RS14990 RS16930 L-ornithine acetylornithine tetrahydrodipicolinate branched-chain- F430 heme b (S)-NADPHX methenyltetrahydromethanopterin methyltransferase: ANME2D_RS13190 ANME2D_RS16190 cleaved DNA α subunit HisH: hisH subunit beta: ANME2D_RS15840 13-DPG 2-propanol O ribulose 1- Asn -D-rhamnose phosphate carbamoyl- transaminase: 4-hydroxy- amino-acid synthase: synthase: ANME2D_RS14090 S-formylglutathione methyl phosphate [tRNA ] bifunctional tryptophan ANME2D_RS01280 cyclohydrolase: mch -2-phosphate phosphate phosphate ANME2D_RS03525 tetrahydrodipicolinate transaminase: ammonia assimilation cycle III cfbE ahbD bifunctional ADP- 5'-deoxy-5'- D-erythro-1-(imidazol-4- ornithine synthase: trpB phosphoenol + dimethylarsonite glutathione AICAR ornithine synthase large reductase: ilvE dependent NAD(P)H- 5,10-methenyltetrahydromethanopterin fluoroadenosine met phosphate H a [protein]-S- (R)-pantothenate acetyltransferase/ ANME2D_RS15365 2-oxobutanoate oxidized pyruvate a guanine in DNA RS17005 yl)-glycerol 3-phosphate carbamoyltransferase: subunit: carB ANME2D_RS04475 protoheme hydrate dehydratase/ RS10290 N-acetylglutamate ammonium coenzyme F430 methyl-L-cysteine imidazoleglycerol- argF glutamine- leu acetolactate synthase: NAD(P)H-hydrate synthase: argJ (S)-2,3,4,5- phosphate hydrolyzing ANME2D_RS06360 glu phosphoenolpyruvate epimerase: tetrahydrodipicolinate trp a thiocarboxylated cyclic cyclic UDP-N-acetyl- dehydratase carbamoyl- ilvN 2-oxoglutarate NADPH- type I synthase: ppsA ANME2D_RS01565 dehypoxanthine a [protein]- a DNA methyl a [protein]-α- a ribonucleoside N-acetyl-L-ornithine LL-diaminopimelate 5,10-methylene- SAM [SAMP] C- pyranopterin dehypoxanthine a uracil in DNA 13-DPG [DNA] an acyl phosphate α-D-glucosamine acetylene APS RS13255 HisB: hisB asp L-citrulline phosphate acetolactate synthase dependent glutamate- a reduced factor 420 futalosine L-cysteine phosphotriester L-glutamate triphosphate RS06190 aminotransferase: tetrahydromethanopterin terminal glycine HsdR family type UDP-N- protein-glutamate O- nitrogenase -ammonia NADPH phosphate futalosine type II glyceraldehyde- acylphosphatase: anaerobic adenylyl- 3-(imidazol-4-yl)-2- L-proline biosynthesis synthase small ANME2D_RS00165 large subunit: glutamate pyruvate acetylglucosamine ligase: glnA I site-specific ANME2D_RS16080 methyltransferase ribonucleoside- component I sulfate kinase: oxopropyl phosphate I (from L-glutamate) subunit: carA ANME2D_RS10920 synthase: gltA 5,10-methylenetetrahydromethanopterin methylated-DNA-- uracil-DNA 3-phosphate argininosuccinate L-phenylalanine dehypoxanthine molybdopterin deoxyribonuclease: 2-epimerase (non- CheR: triphosphate subunit alpha: L-ornithine L,L- [protein]-cysteine S- 1,4-dihydroxy-6- glycosylase: dehydrogenase: acylphosphatase: ANME2D_RS13890 histidinol-phosphate synthase: diphthamide biosynthesis I (S)-2-aceto-2- CO reductase: mer futalosine ANME2D_RS05910 hydrolyzing): ANME2D_RS15075 ANME2D_RS03690 RS13265 carbamoyl phosphate diaminopimelate 2 synthase: naphthoate synthase: ANME2D_RS04075 a double stranded ANME2D_RS05700 a [protein]-L- a 2'- reductase: nrdD L-homoserine biosynthesis I (archaea) hydroxybutanoate asparagine cyclase: mqnC methyltransferase: ANME2D_RS00085 D-glyceraldehyde ANME2D_RS07565 PAPS RS06205 transaminase: ANME2D_RS05565 glu ANME2D_RS09115 ANME2D_RS10955 5 ethene diaminopimelate ammoniumsynthetase B: gln ANME2D_RS14090 DNA with 5'- a carboxylate UDP-N-acetyl-α- glutamate-O deoxyribonucleoside ANME2D_RS03520 biosynthesis an L-histidine- chorismate anaerobic 5 3-phosphate glutamate 5- ANME2D_RS07300 N -methyltetrahydromethanopterin terminal phosphate D-mannosamine -methyl-ester 5'-triphosphate epimerase: carbon-monoxide cyclic an apyrimidinic uracil L-arginino- kinase: proB [translation chorismate mutase: 5'-deoxyadenosine L-histidinol phosphate γ-L-glutamyl ANME2D_RS04840 [+ 14 isozymes] dehydrogenase dehypoxanthine met a [SAMP] C- 1,4-dihydroxy- an unknown site in DNA RS13280 succinate asp elongation factordiphthamide 2] ANME2D_RS16215 (R)-2,3-dihydroxy- molybdopterin a [protein]-S- 5-phosphate meso- catalytic subunit: cooS futalosine terminal glycine [DNA] 6-naphthoate compound RS17170 argininosuccinate aspartate kinase: biosynthesis prephenate 3-methylpentanoate methyl-L-cysteine histidinol phosphate ornithine diaminopimelate [+ 2 isozymes] lyase: argH glutamate-5- ANME2D_RS00225 enzyme phosphatase domain- carbamoyltransferase: prephenate dihydroxy-acid a [methyl-Co(III) semialdehyde L-aspartyl- a 2-[(3S)-3-amino-Dph2: dph2 glu Macromolecule Modification containing protein: argF diaminopimelate dehydratase: dehydratase: ilvD CO corrinoid Fe-S protein] a [lipoyl-carrier protein] an [Fe-S] cluster scaffold 3-[(1-carboxyvinyl) (7,8-dihydropterin- an (R)-2- a guanine 10 an insertion sequence a uridine 54 a [protein]-L- RS06215 dehydrogenase: 4-phosphate 3-carboxypropyl]-L- oxaloacetate pyridoxamine trihomocitrate L-glutamate ANME2D_RS09995 arg decarboxylase: lysA pheA N 6 -octanoyl-L-lysine protein carrying a SAM oxy]benzoate SAM 6-yl)methyl 4-aminobenzoate halocarboxylate in tRNA element IS30 L-homocysteine in tRNA proline (ω = 180) asp ANME2D_RS08880 histidine-[translation (3S)-3-methyl-2- 6 37 5'-phosphate RS02040 N -L-threonylcarbamoyladenosine +2 diphosphate tRNA peptidylprolyl citrate (Si)-synthase: biosynthesis III aspartate- Nucleoside and Nucleotide Biosynthesis [4Fe-4S] cluster tRNA (guanine(10)-N(2) transposase: trans- histidinol elongation factor 2] 3-phenyl-2- L-threonine oxopentanoate archaeosine CO dehydrogenase/ pyridoxamine 5'- aspartate L-glutamate-5- lys -modified tRNA biosynthesis )-dimethyltransferase: ANME2D_RS07510 methionine synthase: pseudouridine(54/ isomerase: ANME2D_RS10585 homoaconitate semialdehyde diphthine synthase: oxopropanoate biosynthesis branched-chain- biosynthesis I CO-methylating phosphate oxidase: 2-oxoglutarate semialdehyde aminofutalosine HAD family hydrolase: 55) synthase Pus10: ANME2D_RS12960 citrate (Si)-synthase: ammonia-lyase: RS06230 histidinol dehydrogenase: lipoyl ANME2D_RS07275 [+ 12 isozymes] ANME2D_RS06890 synthase: aksA ANME2D_RS16390 amino-acid UMP biosynthesis III acetyl-CoA dihydropteroate 2 ANME2D_RS02480 ANME2D_RS00300 NADPH- superpathway of adenosine 5-aminoimidazole thr synthase ANME2D_RS06515 an N - an insertion ANME2D_RS06540 [+ 2 isozymes] ANME2D_RS10915 L-citrulline asd inosine-5'-phosphate biosynthesis III pyrimidine deoxyribonucleotides synthase: lipA 54 dehydrogenase: hisD preQ synthase complex synthase: folP 10 RS03240 L-homoserine transaminase: ilvE 0 MqnE: mqnE a pseudouridine a [protein]-L- 2-oxopimelate dependent nucleotides de novo biosynthesis II ribonucleotide biosynthesis I threonylcarbamoyl- dimethylguanine sequence IS30 with met citrate PLP fumarate histidinol L-aspartate 4- a diphthine-[translation de novo biosynthesis II tRNA subunit beta: cdhC in tRNA proline (ω = 0) glutamate argininosuccinate homoserine kinase: gln AMP synthase: in tRNA integrated transposon dehydrogenase: hisD semialdehyde elongation factor 2] ile hydrogencarbonate guanosine(15) 6 phe AIR PRPP acetyl-CoA a [lipoyl-carrier protein]-N - 2+ 6-amino-6- an (S)-2- RS14935 synthase: (S)-1-pyrroline- synthase: ANME2D_RS02910 formate CTP ANME2D_RS14550 5'-deoxyadenosine sulfide(2-) Fe an [Fe-S] cluster 7,8- a halide anion O-phospho- IMP UTP (L-threonylcarbamoyl) transglycosylase decarbonylase/ [(R)-dihydrolipoyl]-L-lysine met met hydroxycarboxylate gltA histidinal 5-carboxylate ANME2D_RS05565 homoserine asp scaffold protein deoxyfutalosine dihydropteroate L-homoserine anaerobic amidophosphoribosyltransferase: purF adenylate preQ atTgtA: tgtA synthase complex Carboxylate Degradation RS07990 glu pyrroline-5- dehydrogenase: carbamoyl- 0 ribonucleoside- 5-phospho-β- bifunctional N(6)-L- position 15 of subunit gamma: histidinol carboxylate L-arginino-succinate ANME2D_RS08355 a diphthamide- threonine phosphate anaerobic dehydrogenase: hisD adenylosuccinate ribonucleoside- triphosphate D-ribosylamine threonylcarbamoyladenine an archaeal tRNA ANME2D_RS02495 pyruvate decarboxylation to acetyl CoA I RS16615 reductase: [translation synthase: thrC synthase N5-CAIR a single an (S)-2- a 3-sn-phosphatidyl- an [RNA]-3'- a uridine 38- histidinol argininosuccinate L-homoserine synthase: triphosphate reductase: nrdD phosphoribosylamine- synthase/serine/ a 5-methyltetrahydrofolate (R)-mevalonate an adenine in DNA a cytosine in DNA acetyl-CoA pyridoxine precorrin-3B dihomocitrate proC elongation factor 2] [+ 2 isozymes] large L-homocysteine stranded DNA halocarboxylate L-serine ribonucleoside- 40 in tRNA dehydrogenase: hisD lyase: argH ANME2D_RS03615 reductase: nrdD -glycine ligase: purD threonine protein kinase: a [pyruvate dehydrogenase 5'-phosphate RS13395 subunit: carB 5-(carboxyamino)imidazole dCTP acetyl-CoA phosphatidylserine type I restriction- 3'-phosphate DNA cytosine acetyl-CoA C- tRNA precorrin-3B C(17)- trans- ANME2D_RS06715 6 pyridoxamine 5'- pro thr phosphoribosylamine- archaeosine at E2 protein] N -lipoyl-L-lysine modification RNA 3'-terminal acetyltransferase: pseudouridine(38- ribonucleotide mutase: purE 6 decarboxylase: methyltransferase: methyltransferase: homoaconitate glutamine- an N -L- pyruvate pyruvate exodeoxyribonuclease hydroxymethylglutaryl- phosphate cyclase: phosphate oxidase: RS13400 his arg -glycine ligase: purD position 15 of HAD family hydrolase: system subunit M: ANME2D_RS09375 40) synthase hydrolyzing adenylo-succinate dCTP threonylcarbamoyladenine 37 dihydrolipoyl methionine synthase: ANME2D_RS02025 ANME2D_RS16970 cobJ synthase: aksA asp CAIR an archaeal tRNA dehydrogenase VII: ANME2D_RS05760 CoA reductase ANME2D_RS06515 ANME2D_RS12485 ANME2D_RS03495 TruA: truA ANME2D_RS02480 deaminase: dehydrogenase: an L-1- an [RNA]-3'- a 5-methylcytosine [+ 2 isozymes] carbamoyl- GAR in tRNA (acetyl- ANME2D_RS06890 xseA (NADPH): hmgA an N 6 -methyladenine a pseudouridine 38- precorrin-4 2-oxoadipate adenylosuccinate dcd ribonucleoside-2',3'- acetoacetyl-CoA PLP RS16950 phosphate ANME2D_RS10875 transferring) phosphatidylethanolamine in DNA in DNA 40 in tRNA lyase: phosphoribosylglycinamide cyclophosphate synthase ANME2D_RS00280 phosphoribosylaminoimidazolesuccinocarboxamide dihydrolipoyl E1 component an (S)-2- RS03290 dUTP formyltransferase: a tetrahydrofolate a ribonucleoside a single-stranded + a halide anion small synthase: ANME2D_RS11350 dehydrogenase: subunit met HMG-CoA NADPH H ANME2D_RS15665 5'-monophosphate oligodeoxyribonucleotide hydroxycarboxylate subunit: carA deoxyuridine lpdA alpha: pdhA AMP RS03310 5'-triphosphate guanosine SAICAR FGAR a [pyruvate dehydrogenase a [pyruvate dehydrogenase ribonucleotides de carbamoyl nucleotidohydrolase: 6 6 2,5-diamino-6-(5- 13 (2Z,4E)-2- RS09810 asp E2 protein] N - E2 protein] N -S- ω a 2-deoxy-D- UDP a cytidine a uridine 6-carboxy-5,6,7,8- phosphate adenylosuccinate lyase: ANME2D_RS05435 novo biosynthesis phosphoribosylformylglycinamidine -saturated C55 UDP-α-D-glucose a nucleobase nicotinate PRPP a [protein] Ser/Thr acetyl-CoA L-β-lysine (R)-mevalonate adenylate kinase: dihydrolipoyl-L-lysine acetyldihydrolipoyl-L-lysine ribosyl-base phospho-D-ribosylamino) 56 in tRNA in tRNA tetrahydropterin hydroxyhexa- synthase subunit PurL: purL dolichol phosphate adenosylcobalamin- ANME2D_RS06320 ANME2D_RS00280 dUMP pyrimidin-4(3H)-one2,5-diamino-6- serine/threonine tRNA (cytidine(56)-2'- tRNA 7-carboxy-7- 2,4-dienedioate acetyl-CoA putative beta-lysine phosphoribosylformylglycinamidine dependent ribonucleoside- 4-oxalocrotonate mevalonate RS03330 aspartate IMP (ribosylamino)-4(3H) protein kinase: O)-methyltransferase: pseudouridine(13) deazaguanine carboxylase biotin N-acetyltransferase: AICAR synthase I: purQ nucleoside 2- nicotinate diphosphate reductase: tautomerase: RS13500 carbamoyltransferase S-layer glycoprotein synthase TruD: truD synthase QueE: carboxylase subunit: kinase: mvk ADP deoxyribosyltransferase: phosphoribosyltransferase: -pyrimidinone 5'- ANME2D_RS05920 ANME2D_RS01005 ANME2D_RS12770 ANME2D_RS06245 ablB N-glycosyltransferase a 2'-O- 13 ANME2D_RS15540 ANME2D_RS16580 regulatory subunit: formate-- FGAM 2-oxobutanoate phosphate reductase: a [protein] (L-serine/L- a pseudouridine N6-acetyl- (R)-5- ANME2D_RS06480 ANME2D_RS15590 dUDP 56 7-carboxy-7- (3E)-2-oxohex- ANME2D_RS01835 dTMP AglJ: aglJ methylcytidine β phosphoribosylaminoimidazolecarboxamide degradation II 2,5-diamino-6-(5-ANME2D_RS03910 threonine) phosphate in tRNA malonyl-CoA L- -lysine phosphomevalonate RS13535 adenosylcobalamin- adenosylcobalamin- XMP in tRNA deazaguanine 3-enedioate aspartate ligase: ANME2D_RS02645 dTMP kinase: phosphoribosylformylglycinamidine phospho-D-ribitylamino) RS00435 dependent dependent a 2-deoxy-D- carbamoyltransferase: ANME2D_RS14135 cyclo-ligase: ANME2D_RS00720 acetyl-CoA 2-oxobutanoate α-D-glucosyl-(C55 ω- UDP a nucleobase NaMN pyrimidin-4(3H)-one ribonucleoside- ribonucleoside- FAICAR GMP synthase 2-oxoacid:ferredoxin ribosyl-base pyrB dTDP saturated dolichyl phosphate) diphosphate diphosphate subunit A: AIR oxidoreductase bifunctional ANME2D_RS10610 reductase: reductase: nucleoside- subunit beta: RS13555 SecY N-carbamoyl- ANME2D_RS05920 ANME2D_RS05920 phosphoribosylaminoimidazolecarboxamide glutamine- ANME2D_RS01280 an N 10 - an (S)-2- 2,5-diamino-6-(5- dCDP adenosyl-cob(III) 4-hydroxy-3- γ-glutamyl- (7R,8S)- diphosphate kinase: AICAR acetoacetyl-CoA acetyl-CoA H O L-aspartate formyltransferase/IMP cyclohydrolase: purH acetate conversion 2 phospho-D-ribosylamino) precorrin-8x D-threo-isocitrate precorrin-6B precorrin-4 ATP ANME2D_RS09340 hydrolyzing GMP CMP phosphorylation propanoyl-CoA formyltetrahydrofolate halocarboxylate adenosylcobalamin- yrinate a,c-diamide octaprenylbenzoate isopropylamide diaminononanoate to acetyl-CoA pyrimidin-4(3H)-one precorrin-6Y C5,15- dihydroorotase: dADP synthase subunit 2,5-diamino-6- dependent ribonucleoside- UbiD family precorrin-8X isocitrate ferredoxin: precorrin-4 C(11)- dethiobiotin dTTP CMP cobyric acid synthase: methyltransferase IMP GuaA: guaA bifunctional (ribosylamino)-4(3H) diphosphate reductase: decarboxylase: methylmutase: dehydrogenase: ANME2D_RS15640 methyltransferase: synthase: RS00420 RS13575 ANME2D_RS08385 acetate hydroxymethylglutaryl- HAD family hydrolase: ANME2D_RS09950 (decarboxylating) anaerobic phosphoribosylaminoimidazolecarboxamide -pyrimidinone 5'- ANME2D_RS05920 ANME2D_RS06660 ANME2D_RS08850 ANME2D_RS07430 [+ 2 isozymes] cobM bioD CO dehydrogenase/ CoA synthase: ANME2D_RS06515 subunit CbiT: cbiT (S)-dihydroorotate nucleoside- ribonucleoside- GMP formyltransferase/IMP cyclohydrolase: purH phosphate reductase: N-(γ-L-glutamyl) CDP acetyl-CoA synthase propanoate ANME2D_RS07475 CDP adenosylcobyrate 2-octaprenylphenol hydrogenobyrinate 2-oxoglutarate precorrin-5 dethiobiotin diphosphate kinase: triphosphate 2,5-diamino-6-(5-ANME2D_RS03910 -L-alaninol precorrin-8x complex: cdhA cdhB guanosine deoxyribonucleotides de novo biosynthesis II nucleoside- RS13605 dihydroorotate ANME2D_RS09340 reductase: nrdD a (2R)-2- phospho-D-ribitylamino) RS01040 diphosphate kinase: [+ 2 isozymes] a halide anion dehydrogenase acetyl-CoA FAICAR a tetrahydrofolate HMG-CoA hydroxy fatty acid pyrimidin-4(3H)-one electron ANME2D_RS09340 GDP transfer subunit: dATP CTP ATP GDP ANME2D_RS05280 an [amino-group carrier protein]- + + RS08525 pyridin-1-ium-3-carboxylate-5- + an (R)-2- dCDP nicotinate adenine UTP H synthase H a [LarE]-L-cysteine H hydrogencarbonate γ uroporphyrinogen-III a DNA segment GDP-β-L-fucose methylarsonite 2-oxoglutarate dihydroorotate adenosylcobalamin- adenosylcobalamin- thiocarboxylate mononucleotide halocarboxylate C-terminal- -(L-glutamate 5- dinucleotide thr archaeal nucleoside- adenosylcobalamin- anaerobic dehydrogenase: dependent dependent semialdehyde-2-yl)-L-glutamateN-acetyl-gamma- uroporphyrinogen-III recombinase RecA: GDP-L-fucose arsenite trans- diphosphate kinase: dependent ribonucleoside- NAD+ synthase: L-threonine 3- ribonucleoside- ANME2D_RS05275 UTP and CTP de ribonucleoside- ribonucleoside- glutamyl-phosphate C-methyltransferase: ANME2D_RS08340 synthase: methyltransferase: homoaconitate ANME2D_RS09340 ATP-dependent carbonate diphosphate reductase: ANME2D_RS17590 dehydrogenase: triphosphate RS00480 RS12415 PRPP novo biosynthesis diphosphate diphosphate HAD family hydrolase: reductase: cobA ANME2D_RS07615 arsM synthase: aksA orotate sacrificial sulfur dehydratase: ANME2D_RS05920 [+ 4 isozymes] ANME2D_RS00330 reductase: nrdD reductase: reductase: ANME2D_RS06515 ANME2D_RS15420 a DNA segment in GDP-4-dehydro- UMP transferase LarE: larE ANME2D_RS11480 an [amino-group carrier protein]- CDP + dUTP ANME2D_RS05920 ANME2D_RS05920 GTP precorrin-2 NAD α-D-rhamnose dimethylarsonite aminoacetone (2R)-homocitrate orotate UMP kinase: C-terminal-γ-(5-phospho- reverse orientation GTP phosphoribosyltransferase: ANME2D_RS14710 pyrimidine deoxyribonucleotide phosphorylation a (2R)-2- L-glutamyl)-L-glutamate RS02205 RS05225 pyridin-1-ium-3,5- a halide anion pyrE UDP dGDP a [LarE]-dehydroalanine CO H O bisthiocarboxylate mononucleotide 2 2 hydroxy fatty acid nucleoside- dTMP dCMP dTMP kinase: orotidine 5'- diphosphate kinase: anaerobic ANME2D_RS14135 phosphate ANME2D_RS09340 ribonucleoside- nucleoside- pyridin-1-ium-3,5- DNA combined with exogenous DNA an [amino-group carrier protein]-C- UDP 3-phospho- (S)-2-aceto-2- 2'-deoxycytidine cytidine CTP RS10690 RS05235 dTDP dCDP a [LarE]-L-cysteine THMPT 2-phosphoglycolate dimethylarsonite triphosphate diphosphate kinase: dicarboxylate mononucleotide to form a recombinational junction terminal-γ-(L-ornithyl)-L-glutamate D-glycerate hydroxybutanoate asp UTP adenosylcobalamin- anaerobic orotidine-5'- reductase: nrdD ANME2D_RS09340 nucleoside- nucleoside- dihydromethanopterin ketol-acid cytidine deaminase: cytidine deaminase: crossover junction acetylornithine dependent ribonucleoside- phosphoglycerate phosphoglycolate arsenite aspartate ribonucleoside- phosphate CTP synthase diphosphate kinase: diphosphate kinase: reductase (acceptor) phosphatase: reductoisomerase: ANME2D_RS07940 methyltransferase: ANME2D_RS07940 ATP-dependent endodeoxyribonuclease transaminase: diphosphate reductase: dehydrogenase: dehydrogenase: triphosphate decarboxylase: (glutamine ANME2D_RS09340 ANME2D_RS09340 : ANME2D_RS15915 ANME2D_RS12685 ilvC arsM RS08170 sacrificial sulfur RuvC: ruvC ANME2D_RS03525 ANME2D_RS05920 ANME2D_RS00220 2'-deoxyuridine ANME2D_RS04995 uridine reductase: nrdD RS08160 pyrF hydrolyzing): pyrG dGTP an [amino-group carrier protein]- dTTP dCTP resolution of recombinational junction (R)-2,3-dihydroxy- transferase LarE: larE C-terminal-γ-(L-glutamate 5- 7,8-dihydromethanopterin dUDP 3-phosphooxypyruvate glycolate trimethylarsine oxaloacetate dCTP UMP CTP formation of two intact strands 3-methylpentanoate semialdehyde-2-yl)-L-glutamate pyridin-1-ium-3-carboxylate-5- PhnD a [LarE]-dehydroalanine thiocarboxylate mononucleotide RS12605

RS08185 phosphate

RS08540 RS08505 RS14510 RS00475 RS05170 RS08770 RS00400 RS12125 RS17010 RS08445 RS03205 RS16505 RS01450 RS11985 RS04905 RS03060 RS16285 RS00115 RS15160 RS02995 RS07730 RS04835 RS15115 RS05970 FlaJ RS01250 RS16565 RS02940 RS13005 NdhC RS16520 RS04670 RS14970 RS14595 RS04595 RS07630 RS04560 RS05845 RS15005 RS04485 RS04450 RS14070 TrkA RS04545 RS07620 CbiQ RS05860 RS17065 HtpX RS04655 RS04675 RS02920 RS09705 RS15045 RS05940 RS01610 RS05960 RS05965 PstB RS05975 RS07725 RS15150 RS05995 RS03005 ArtC RS17180 RS00215 RS09570 RS07880 RS00265 RS16730 RS13275 RS08710 RS13360 RS05090 RS14965 RS00440 RS06375 RS08135 RS06415 RS13725 RS17465 RS08545 RS02250 RS06470 RS08550 TatA RS05270 RS01785 RS13755 RS15755 RS13760 RS15760 RS11470 RS00860 RS13765 RS03855 RS15765 RS16700 RS13770 ATPase RS03860 RS08590 RS15195 RS01770 RS15790 RS15795

phosphate This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.