Amended Safety Assessment of Parabens as Used in Cosmetics Status: Draft Final Amended Report for Panel Review Release Date: March 15, 2019 Panel Meeting Date: April 8-9, 2019 The 2019 Cosmetic Ingredient Review Expert Panel members are: Chair, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; Ronald A. Hill, Ph.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; James G. Marks, Jr., M.D.; Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. The CIR Executive Director is Bart Heldreth, Ph.D. This report was prepared by Jinqiu Zhu, Ph.D., Toxicologist. © Cosmetic Ingredient Review 1620 L Street, NW, Suite 1200 ♢ Washington, DC 20036-4702 ♢ ph 202.331.0651 ♢ fax 202.331.0088
[email protected] Distributed for Comment Only -- Do Not Cite or Quote Commitment & Credibility since 1976 MEMORANDUM To: CIR Expert Panel and Liaisons From: Jinqiu Zhu, PhD, DABT, ERT Toxicologist Date: March 15, 2019 Subject: Draft Final Amended Safety Assessment of Parabens as Used in Cosmetics Attached is the Draft Final Amended Report of 20 parabens and 4-Hydroxybenzoic Acid, as used in cosmetics (parabe042019FAR). At the September 2018 meeting, the Panel issued a tentative amended report for public comment with the conclusion that the following 20 ingredients are safe in cosmetics in the present practices of use and concentration described in the safety assessment. Butylparaben Potassium Ethylparaben* Sodium Isobutylparaben Calcium Paraben* Potassium Methylparaben* Sodium Isopropylparaben* Ethylparaben Potassium Paraben* Sodium Methylparaben Isobutylparaben Potassium Propylparaben* Sodium Paraben* Isopropylparaben Propylparaben Sodium Propylparaben Methylparaben Sodium Butylparaben 4-Hydroxybenzoic Acid* Potassium Butylparaben* Sodium Ethylparaben * Not reported to be in current use.