Selective Tumor Antigen Vaccine Delivery to Human CD169+ Antigen-Presenting Cells Using Ganglioside-Liposomes
Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes Alsya J. Affandia, Joanna Grabowskaa, Katarzyna Oleseka, Miguel Lopez Venegasa,b, Arnaud Barbariaa, Ernesto Rodrígueza, Patrick P. G. Muldera, Helen J. Pijffersa, Martino Ambrosinia, Hakan Kalaya, Tom O’Toolea, Eline S. Zwarta,c, Geert Kazemierc, Kamran Nazmid, Floris J. Bikkerd, Johannes Stöckle, Alfons J. M. van den Eertweghf, Tanja D. de Gruijlf, Gert Stormg,h, Yvette van Kooyka,b, and Joke M. M. den Haana,1 aDepartment of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands; bDC4U, 3621 ZA Breukelen, The Netherlands; cDepartment of Surgery, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands; dDepartment of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam and University of Amsterdam, 1081 LA Amsterdam, The Netherlands; eInstitute of Immunology, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria; fDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands; gDepartment of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, The Netherlands; and hDepartment of Biomaterials, Science and Technology, Faculty of Science and Technology, University of Twente, 7522 NB Enschede, The Netherlands Edited by Peter Cresswell, Yale University, New Haven, CT, and approved September 3, 2020 (received for review April 2, 2020) Priming of CD8+ T cells by dendritic cells (DCs) is crucial for the consuming, and costly process, research is shifting toward tar- generation of effective antitumor immune responses.
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