INTRODUCTION to ADAPTIVE OPTICS and ITS HISTORY Claire
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Network Chromatography Interface 901/902 Operator's Manual
Network Chromatography Interface 901/902 Operator’s Manual Release History Part Number Release Publication Date N515-6030 A April 2001 Any comments about the documentation for this product should be addressed to: User Assistance PerkinElmer Instruments LLC 710 Bridgeport Avenue Shelton, Connecticut 06484-4794 U.S.A Or emailed to: [email protected] Notices The information contained in this document is subject to change without notice. PerkinElmer makes no warranty of any kind with regard to the material, including, but not limited to, the implied warranties of merchantability and fitness for a particular purpose. PerkinElmer shall not be liable for errors contained herein for incidental consequential damages in connection with furnishing, performance or use of this material. NOTE: TotalChrom is the updated version of the software previously marketed as Turbochrom. This product is compatible with TotalChrom and Turbochrom version 6.1.x. The term TotalChrom has been used throughout this document to denote either system. Copyright Information This document contains proprietary information that is protected by copyright. All rights are reserved. No part of this publication may be reproduced in any form whatsoever or translated into any language without the prior, written permission of PerkinElmer Instruments LLC. Copyright © 2001 PerkinElmer Instruments LLC. Trademarks Registered names, trademarks, etc. used in this document, even when not specifically marked as such, are protected by law. PerkinElmer is a registered trademark of PerkinElmer, Inc. Network Chromatography Interface, NCI, Access*Chrom, TotalChrom, TotalChrom Client/Server, and TotalChrom Workstation are trademarks of PerkinElmer Inc. Turbochrom is a trademark of Applera Corporation. Table of Contents Chapter 1 Introduction.............................................................................................1 NCI 901 Operates on Channel A Only ...................................................................................... -
SIRION Biotech to Be Acquired by Perkinelmer Torreya Advised SIRION on the Transaction Munich, Germany, June 22, 2021
SIRION Biotech to be acquired by PerkinElmer Torreya advised SIRION on the transaction Munich, Germany, June 22, 2021 PerkinElmer, Inc. announced it has entered into an agreement to acquire SIRION Biotech GmbH (“SIRION”), a global provider of viral vector-based technologies that drive improved delivery performance for cell and gene therapies. The acquisition is expected to close during the third quarter of 2021. Founded in 2005, SIRON is a leading commercial supplier of viral vector technologies for gene and cell therapy as well as vaccine development. SIRION develops novel therapeutic viral vectors and uses proprietary technology platforms based on lenti-, adeno-, and adenoassociated viruses, to expedite its customers’ advances in drug development. Additionally, SIRION has established a strong licensing portfolio leveraged by over a dozen major pharmaceutical and biotech players researching more than twenty-five diseases and conditions. The addition of SIRION’s offerings will complement PerkinElmer’s Horizon Discovery portfolio which includes gene editing and modulation tools for CRISPR, CRISPRi and RNAi, custom cell lines for bioproduction and base editing technologies. SIRION will benefit from becoming part of the PerkinElmer portfolio, with increased access to genomics analysis, gene editing and base editing technologies, as well as a strong global infrastructure and reach. Torreya advised SIRION on the transaction, which highlights both Torreya’s expertise in the bioproduction space and deep relationships within the biotech community. -
List of SARS-Cov-2 Diagnostic Test Kits and Equipments Eligible For
Version 33 2021-09-24 List of SARS-CoV-2 Diagnostic test kits and equipments eligible for procurement according to Board Decision on Additional Support for Country Responses to COVID-19 (GF/B42/EDP11) The following emergency procedures established by WHO and the Regulatory Authorities of the Founding Members of the GHTF have been identified by the QA Team and will be used to determine eligibility for procurement of COVID-19 diagnostics. The product, to be considered as eligible for procurement with GF resources, shall be listed in one of the below mentioned lists: - WHO Prequalification decisions made as per the Emergency Use Listing (EUL) procedure opened to candidate in vitro diagnostics (IVDs) to detect SARS-CoV-2; - The United States Food and Drug Administration’s (USFDA) general recommendations and procedures applicable to the authorization of the emergency use of certain medical products under sections 564, 564A, and 564B of the Federal Food, Drug, and Cosmetic Act; - The decisions taken based on the Canada’s Minister of Health interim order (IO) to expedite the review of these medical devices, including test kits used to diagnose COVID-19; - The COVID-19 diagnostic tests approved by the Therapeutic Goods Administration (TGA) for inclusion on the Australian Register of Therapeutic Goods (ARTG) on the basis of the Expedited TGA assessment - The COVID-19 diagnostic tests approved by the Ministry of Health, Labour and Welfare after March 2020 with prior scientific review by the PMDA - The COVID-19 diagnostic tests listed on the French -
8. Adaptive Optics 299
8. Adaptive Optics 299 8.1 Introduction Adaptive Optics is absolutely essential for OWL, to concentrate the light for spectroscopy and imaging and to reach the diffraction limit on-axis or over an extended FoV. In this section we present a progressive implementation plan based on three generation of Adaptive Optics systems and, to the possible extent, the corresponding expected performance. The 1st generation AO − Single Conjugate, Ground Layer, and distributed Multi-object AO − is essentially based on Natural Guide Stars (NGSs) and makes use of the M6 Adaptive Mirror included in the Telescope optical path. The 2nd generation AO is also based on NGSs but includes a second deformable mirror (M5) conjugated at 7-8 km – Multi-Conjugate Adaptive Optics − or a post focus mirror conjugated to the telescope pupil with a much higher density of actuators -tweeter- in the case of EPICS. The 3rd generation AO makes use of single or multiple Laser Guide Stars, preferably Sodium LGSs, and should provide higher sky coverage, better Strehl ratio and correction at shorter wavelengths. More emphasis in the future will be given to the LGS assisted AO systems after having studied, simulated and demonstrated the feasibility of the proposed concepts. The performance presented for the AO systems is based on advances from today's technology in areas where we feel confident that such advances will occur (e.g. the sizes of the deformable mirrors). Even better performance could be achieved if other technologies advance at the same rate as in the past (e.g. the density of actuators for deformable mirrors). -
Subaru Super Deep Field (SSDF) with AO
Subaru Super Deep Field (SSDF) using Adaptive Optics Yosuke Minowa (NAOJ) on behalf of Yoshii, Y. (IoA, Univ. of Tokyo; PI) and SSDF team: Kobayashi, N. (IoA, Univ. of Tokyo), Totani, T. (Kyoto Univ.), Takami, H., Takato, N. Hayano, Y., Iye, M. (NAOJ). Subaru UM (1/30/2007) SSDF project: What? { Scientific motivation 1. Study the galaxy population at the unprecedented faint end (K’=23-25mag) to find any new population which may explain the missing counterpart to the extragalactic background light. 2. Study the morphological evolution of field galaxies in rest-frame optical wavelengths to find the origin of Hubble sequence. Æ high-resolution deep imaging of distant galaxies SSDF project: How? { Deep imaging of high-z galaxies with AO. z Improve detection sensitivity. Peak intensity: with AO ~ 10-20 times higher 0”.07 without AO z Improve spatial 0”.4 resolution FWHM < 0”.1 AO is best suited for the deep imaging study of high-z galaxies which requires both high-sensitivity and high-resolution. z SSDF project: Where? { Target field: a part of “Subaru Deep Field” (SDF) z Originally selected to locate near a bright star for AO observations (Maihara+01). z Optical~NIR deep imaging data are publicly available. { Enable the SED fitting of detected galaxies. Æ phot-z, rest-frame color, (Maihara+01) stellar mass… Observations { AO36+IRCS at Cassegrain z K’-band (2.12um) imaging with 58mas mode z providing 1x1 arcmin2 FOV AO36 IRCS To achieve unprecedented faint-end, we concentrated on K’-band imaging of this 1arcmin2 field, rather than wide-field or multi-color imaging. -
Onesource Multi-Vendor Service
qualifyMaintain all of your and and GC,GC/MS HPLC, systems LC/MS, Multi-Vendor Service One contract One contact One solution You depend on your GC, HPLC, LC/MS • Which manufacturer do you call when your chromatography system goes down? or GC/MS to work reliably, day • How do you get the rapid and effective response you need? after day. But maintenance and • How do you ensure each component is in compliance with FDA regulations and that the overall system is in compliance? compliance can be a real challenge Now you can reduce downtime, increase your lab’s productivity and enhance if your total analysis system has compliance with the help of OneSource® Multi-Vendor Service. components from different Rely on ONE expert PerkinElmer Service Engineer who can provide customized preventative maintenance, repair and qualification services for your entire chromatography manufacturers. chromatography system, regardless of manufacturer. Focus on the science. We handle the rest. One proven, cost-effective solution can keep your chromatography systems at peak performance. That’s OneSource Multi-Vendor Service. • One point of service contact — • Dedicated multi-vendor support • Standardized reporting and total system approach to maintenance, team — takes ownership of your issues: documentation — provides enhanced repair and qualification: - Ensures rapid deployment of traceability of system maintenance - Eliminates multiple service visits, your local Service Engineer. and repair history; improves regulatory saving you time and money. - Provides parts sourcing over the compliance. - Reduces service contract lifetime of your equipment. • Maximum system uptime and administration costs. • One expert Service Engineer — equipment availability —no - Reduces time lab personnel are on our highly trained PerkinElmer engineers downtime due to multiple vendors’ lack the phone with multiple service can provide customized preventative of total system understanding, thus providers. -
Modern Astronomical Optics 1
Modern Astronomical Optics 1. Fundamental of Astronomical Imaging Systems OUTLINE: A few key fundamental concepts used in this course: Light detection: Photon noise Diffraction: Diffraction by an aperture, diffraction limit Spatial sampling Earth's atmosphere: every ground-based telescope's first optical element Effects for imaging (transmission, emission, distortion and scattering) and quick overview of impact on optical design of telescopes and instruments Geometrical optics: Pupil and focal plane, Lagrange invariant Astronomical measurements & important characteristics of astronomical imaging systems: Collecting area and throughput (sensitivity) flux units in astronomy Angular resolution Field of View (FOV) Time domain astronomy Spectral resolution Polarimetric measurement Astrometry Light detection: Photon noise Poisson noise Photon detection of a source of constant flux F. Mean # of photon in a unit dt = F dt. Probability to detect a photon in a unit of time is independent of when last photon was detected→ photon arrival times follows Poisson distribution Probability of detecting n photon given expected number of detection x (= F dt): f(n,x) = xne-x/(n!) x = mean value of f = variance of f Signal to noise ration (SNR) and measurement uncertainties SNR is a measure of how good a detection is, and can be converted into probability of detection, degree of confidence Signal = # of photon detected Noise (std deviation) = Poisson noise + additional instrumental noises (+ noise(s) due to unknown nature of object observed) Simplest case (often -
Adaptive Optics: an Introduction Claire E
1 Adaptive Optics: An Introduction Claire E. Max I. BRIEF OVERVIEW OF ADAPTIVE OPTICS Adaptive optics is a technology that removes aberrations from optical systems, through use of one or more deformable mirrors which change their shape to compensate for the aberrations. In the case of adaptive optics (hereafter AO) for ground-based telescopes, the main application is to remove image blurring due to turbulence in the Earth's atmosphere, so that telescopes on the ground can "see" as clearly as if they were in space. Of course space telescopes have the great advantage that they can obtain images and spectra at wavelengths that are not transmitted by the atmosphere. This has been exploited to great effect in ultra-violet bands, at near-infrared wavelengths that are not in the atmospheric "windows" at J, H, and K bands, and for the mid- and far-infrared. However since it is much more difficult and expensive to launch the largest telescopes into space instead of building them on the ground, a very fruitful synergy has emerged in which images and low-resolution spectra obtained with space telescopes such as HST are followed up by adaptive- optics-equipped ground-based telescopes with larger collecting area. Astronomy is by no means the only application for adaptive optics. Beginning in the late 1990's, AO has been applied with great success to imaging the living human retina (Porter 2006). Many of the most powerful lasers are using AO to correct for thermal distortions in their optics. Recently AO has been applied to biological microscopy and deep-tissue imaging (Kubby 2012). -
A Review of Astronomical Science with Visible Light Adaptive Optics
A review of astronomical science with visible light adaptive optics Item Type Article Authors Close, Laird M. Citation Laird M. Close " A review of astronomical science with visible light adaptive optics ", Proc. SPIE 9909, Adaptive Optics Systems V, 99091E (July 26, 2016); doi:10.1117/12.2234024; http:// dx.doi.org/10.1117/12.2234024 DOI 10.1117/12.2234024 Publisher SPIE-INT SOC OPTICAL ENGINEERING Journal ADAPTIVE OPTICS SYSTEMS V Rights © 2016 SPIE. Download date 30/09/2021 19:37:34 Item License http://rightsstatements.org/vocab/InC/1.0/ Version Final published version Link to Item http://hdl.handle.net/10150/622010 Invited Paper A Review of Astronomical Science with Visible Light Adaptive Optics Laird M. Close1a, aCAAO, Steward Observatory, University of Arizona, Tucson AZ 85721, USA; ABSTRACT We review astronomical results in the visible (λ<1μm) with adaptive optics. Other than a brief period in the early 1990s, there has been little (<1 paper/yr) night-time astronomical science published with AO in the visible from 2000-2013 (outside of the solar or Space Surveillance Astronomy communities where visible AO is the norm, but not the topic of this invited review). However, since mid-2013 there has been a rapid increase visible AO with over 50 refereed science papers published in just ~2.5 years (visible AO is experiencing a rapid growth rate very similar to that of NIR AO science from 1997-2000; Close 2000). Currently the most productive small (D < 2 m) visible light AO telescope is the UV-LGS Robo-AO system (Baranec, et al. -
Complete Listing of All Statewide Contracts
Procurement Services All Term Contracts by Group Number Contract Contract Contractor Group Description Period Award# MB/WB No. Name / SB 01600 MILK (FLUID) (STATEWIDE) 9/21/2015 - 9/20/2021 22773 PC67026 CREAM-O-LAND DAIRIES LLC 01600 MILK (FLUID) (STATEWIDE) 9/21/2015 - 9/20/2021 22773 PC67027 UPSTATE NIAGARA COOPERATIVE INC 01600 MILK (FLUID) (STATEWIDE) 9/21/2015 - 9/20/2021 22773 PC68955 HUDSON VALLEY FRESH DAIRY LLC 01600 MILK (FLUID) (STATEWIDE) 9/21/2015 - 9/20/2021 22773 PC68964 UPSTATE FARMS DAIRY LLC 01800 ROAD SALT, TREATED SALT & EMERGENCY STANDY SALT 9/1/2018 - 8/31/2022 23134 PC68227 AMERICAN ROCK SALT COMPANY LLC 01800 ROAD SALT, TREATED SALT & EMERGENCY STANDY SALT 9/1/2018 - 8/31/2022 23134 SB PC68228 APALACHEE LLC 01800 ROAD SALT, TREATED SALT & EMERGENCY STANDY SALT 9/1/2018 - 8/31/2022 23134 SB PC68229 ATLANTIC SALT INC 01800 ROAD SALT, TREATED SALT & EMERGENCY STANDY SALT 9/1/2018 - 8/31/2022 23134 PC68230 CARGILL INC SALT ROAD SAFETY 01800 ROAD SALT, TREATED SALT, & EMERGENCY STANDBY SALT (STATEWIDE) 9/1/2019 - 8/31/2022 23175 PC68889 AMERICAN ROCK SALT COMPANY LLC 01800 ROAD SALT, TREATED SALT, & EMERGENCY STANDBY SALT (STATEWIDE) 9/1/2019 - 8/31/2022 23175 SB PC68890 APALACHEE LLC 01800 ROAD SALT, TREATED SALT, & EMERGENCY STANDBY SALT (STATEWIDE) 9/1/2019 - 8/31/2022 23175 SB PC68891 ATLANTIC SALT INC 01800 ROAD SALT, TREATED SALT, & EMERGENCY STANDBY SALT (STATEWIDE) 9/1/2019 - 8/31/2022 23175 PC68892 CARGILL INC SALT ROAD SAFETY 01800 ROAD SALT, TREATED SALT & EMERGENCY STANDBY SALT 9/18/2020 - 8/31/2022 23212 -
Adaptive Optics
Adaptive Optics Ruobing Dong Large portion is adopted from Claire Max’s lecture in UCSC 03/30/2011 Why is adaptive optics needed? Turbulence in earth’s atmosphere makes stars twinkle More importantly, turbulence spreads out light; makes it a blob rather than a point Even the largest ground-based astronomical telescopes have no better resolution than an 8" telescope Atmospheric perturbations cause distorted wavefronts Rays not Patten changes parallel at time scale of ~10ms each small parallel beam makes a Index of diffraction limited Plane spot on the image refraction Distorted plane Wave variations Wavefront Characterize turbulence strength by quantity r0 Wavefront of light r0 Primary mirror of telescope • “Coherence Length” r0 : Diameter of the circular pupil for which the diffraction limited image and the seeing limited image have the same angular resolution. (r0 ~ 15 - 30 cm at good observing sites • Pupil larger than r0, images are seeing dominated. Real time sequence from a A much larger small telescope with telescope, aperture aperture the size of r0 contains many r0 Schematic of adaptive optics system Feedback loop: next cycle corrects the (small) errors of the last cycle How does adaptive optics help? (cartoon approximation) Adaptive optics increases peak intensity of a point source Lick Observatory" No AO" With AO" Intensity" No AO" With AO" AO produces point spread functions with a “core” and “halo” Definition of “Strehl”: Ratio of peak intensity to that of “perfect” optical system" " Intensity x" When AO system performs well, -
Advantages of a High Throughput Sample Introduction System for Drinking Water Analyses Using ICP-MS
APPLICATION NOTE ICP - Mass Spectrometry Authors: Ram Lamsal Queen's University, Department of Chemistry Kingston, ON, Canada Eve Kroukamp PerkinElmer Inc. Woodbridge, ON, Canada Advantages of a High Throughput Sample Introduction System in the Introduction Water forms 80% of Analysis of Drinking Waters Using the human body and is essential to all life. Due to ICP-MS (Method 200.8) increasing pollution and land disturbance, vast quantities of potentially harmful elements are mobilized into potable water sources, such as rivers, lakes and groundwater. As such, the concentrations of elements, which are known to elicit a toxicological response, are regulated throughout the world by international and national regulations, of which one of the most commonly used methods is the United States Environmental Protection Agency 200.8 (EPA 200.8). Since all drinking waters need to be tested prior to distribution to ensure fitness for consumption, this makes sample loads on water-testing laboratories high. In such settings, sample throughput is often hindered by the length of the uptake and washout times, and since lengthy run times cause an increase in the cost of analysis, the laboratory’s overheads in routine testing can be very high. Where speed is a priority, sample-to-sample analysis time can (CRMs): Trace Metals in Drinking Water (High Purity Standards™, be dramatically decreased through the implementation of Charleston, South Carolina, USA), 1640a Natural Water and 1643f selector valves and vacuum pumps, where a loop is filled with Water (NIST, Rockville, Maryland, USA). The robustness of the method sample under vacuum and the sample is introduced to the was further validated through the implementation of low concentration plasma at a constant rate.