Current Awareness in Clinical Toxicology Editors: Damian Ballam Msc and Allister Vale MD

Home , Flunitrazolam, Formetanate, Nileema Mishra, Paan

Current Awareness in Clinical Toxicology Editors: Damian Ballam MSc and Allister Vale MD

April 2017

CONTENTS General Toxicology 10 Metals 38 Management 21 Pesticides 39 Drugs 23 Chemical Warfare 41 Chemical Incidents & 33 Plants 42 Pollution Chemicals 33 Animals 42

CURRENT AWARENESS PAPERS OF THE MONTH

Antivenom for European Vipera species envenoming Lamb T, de Haro L, Lonati D, Brvar M, Eddleston M. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1300261: Background European viper bite is relatively uncommon but can cause serious envenoming, particularly swelling and hemorrhage spreading from limb to trunk that can cause long term disability. Systemic features are relatively mild compared to many other venomous species. Moderate- to-severe envenoming requires antivenom, which is given many hundreds of times each year across the continent. Several Vipera spp antivenoms are produced in Europe, but there is little comparative information available for the antivenoms and none is licensed with the European Medicines Agency. We aimed to collect descriptive data on European viper antivenoms and assess their relative effectiveness. Methods A systematic review of articles relating to antivenom in Europe was performed using the Medline medical database. The following keywords "Europ*" or the individual names of each European country and "antiven*" or "immun*" or "envenom*" and "snake" or "viper*" or "adder" were used. Articles published between 1 January 1996 and 11 March 2016 pertaining

Current Awareness in Clinical Toxicology is produced monthly for the American Academy of Clinical Toxicology by the Birmingham Unit of the UK National Poisons Information Service, with contributions from the Cardiff, Edinburgh, and Newcastle Units.

The NPIS is commissioned by Public Health England

to clinical outcome, including case reports, were selected. Referenced articles in the indexed articles were explored for suitability and included if they met any of the criteria: specific antivenom used, route of antivenom administration, adverse reactions to antivenom therapy and length of hospital admission. All accepted abstracts from EAPCCT conferences since 2000 were searched and abstracts relating to Vipera spp envenoming were assessed for suitability. We extracted data on study type, safety and effectiveness. We sought information on antivenoms from manufacturers and individual patient data from authors of publications. Since individual patient data were only rarely available, we compared median length of stay between case series reporting each antivenom. We identified 40 papers and six published abstracts, and one unpublished paper that reported clinical cases and case series of envenomed patients treated with antivenom. No publication reported randomized controlled trials comparing any European Vipera antivenom with either placebo or another antivenom. 25 reports were of retrospective hospital- (n = 13) or poison center-based (n = 12) case series including five or more patients; a further 12 reports were either case reports or case series with less than five patients and one paper was a limited literature review. An additional nine papers reported prospective data; seven collected data remotely through poison service telephone communication with the attending physicians. Antivenoms available in Europe Eight antivenoms are available for European Vipera spp envenoming; a material safety data sheet providing information on manufacture was available for seven. Six are raised against V. berus or V. ammodytes venom; the seventh is raised against a mixture of V. ammodytes, V. aspis and V. berus venom and the eighth is raised against V. ammodytes, Macrovipera lebetina and Montivipera xanthina venom. Six manufacturers recommended intramuscular administration while two recommended intravenous administration. No randomized control trials comparing the effectiveness of antivenoms were identified. Pre-clinical data We found two papers presenting comparative preclinical data. Clinical data Clinical studies were predominantly retrospective and contained clinical data on antivenom used in 2602 patients; where the antivenom was identified (n = 2174), 2061 (94.8%) received Zagreb, ViperFAV or ViperaTAb antivenoms. There were few published data on the other antivenoms. Repeated use of antivenom Repeat doses were reported in 230/1491 of cases (15.4%) where this information was recorded. Outcome and length of hospital stay Intravenous administration of antivenom was associated with shorter length of hospital stay (median length of hospital stay in studies of intravenous ViperFAV or ViperaTAb ranged from 1 to 4.8 days versus 2 to 18 days for intramuscular Bulbio or Zagreb antivenoms). Antivenom versus no antivenom Some small studies demonstrated no difference in the length of hospital stay in patients with equivalent envenomation grading who either did or did not receive antivenom. Adverse events Adverse reactions were reported in 37 of 2408 cases (1.5%) including seven cases of anaphylaxis. Conclusions There are very limited pre-clinical comparative data and no randomised controlled trials assessing effectiveness of the antivenoms against different Vipera species. Most descriptive data suggest the efficacy of Zagreb, ViperFAV and ViperaTAb antivenoms by the intravenous route but not intramuscular route, although this is level D evidence. Reported adverse

reactions were rare, suggesting that the modern intravenous antivenoms are of good quality. Better and more systematic data, including perhaps randomized controlled trials comparing different antivenoms, are required for the many hundreds of antivenom administrations that occur annually across Europe. Full text available from: http://dx.doi.org/10.1080/15563650.2017.1300261

Toxicity from fluoropolymer-containing grout, tile and stone floor sealants reported to the UK National Poisons Information Service 2009–2015 Henke D, Campbell A, Bradberry SM, Sandilands EA, Thomas SHL, Thompson JP, Vale JA. Clin Toxicol 2017; online early: doi: 10.1080/ 15563650.2017.1296154: Context Grout, tile and floor stone sealants contain a solvent, a water-repelling agent and in the case of aerosols a propellant. The water-repelling agent used is typically a fluoropolymer resin, a silicon-based resin, or a combination of both. Objective To report the clinical course in patients exposed to fluoropolymer-containing sealants referred to the United Kingdom National Poisons Information Service. Methods A retrospective analysis was performed of telephone enquiries received between 2009 and 2015. Results 101 enquiries involving 96 exposures were received. The majority of the exposures (n = 88) occurred when the sealant was delivered from an aerosol. Twelve patients were exposed occupationally and the remainder were exposed while using the product at home. Eighty- nine exposures were as a result of inhalation alone, two followed ingestion, three skin contact and one eye contact; one involved inhalation and eye contact. All 90 patients exposed by inhalation developed clinical features: 31 had a World Health Organisation/ International Programme on Chemical Safety/European Commission/European Association of Poison Centres and Clinical Toxicologists Poisoning Severity Score of 1 (minor toxicity), 51 patients had features of moderate toxicity (PSS 2) and eight were graded PSS 3 (severe poisoning). The most common features were dyspnea (n = 52; 57.8%; 95% CI = 47.0– 68.5), chest pain/tightness (n = 34; 37.8%; 95% CI = 27.2–48.4), coughing (n = 27; 30.0%; 95% CI = 20.0–40.0) and sinus tachycardia (n = 11; 12.2%; 95% CI = 4.1–18.2); hypoxemia was present in 20 (22.2%; 95% CI = 13.1–31.4). At the time of the enquiry a chest X-ray had been performed on 15 patients: in eight patients (all of whom were PSS 3) the X-ray was reported as being abnormal and showed bilateral shadowing. Conclusions This study demonstrates that if fluoropolymer-containing sealants are inhaled then clinical features may occur and in a small proportion (9%) these features may be severe. Full text available from: http://dx.doi.org/10.1080/15563650.2017.1296154

Underestimated impact of novel psychoactive substances: laboratory confirmation of recreational drug toxicity in Oslo, Norway Vallersnes OM, Persett PS, Øiestad EL, Karinen R, Heyerdahl F, Hovda KE. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1312002: Context Recreational drug toxicity is frequent. Availability of new psychoactive substances is steadily increasing. However, data with verified analyses from clinical settings are limited. To evaluate the impact of novel psychoactive substances (NPS) on recreational drug toxicity in Oslo, Norway, we analysed samples from a selection of patients. Methods All the patients presenting with recreational drug toxicity at the Oslo Accident and Emergency Outpatient Clinic (OAEOC) and at the Oslo University Hospital (OUH) were registered from April through September 2014. Oral fluid samples were collected at the OAEOC. Blood samples were collected at the OUH. The samples were screened using ultra- high performance liquid chromatography – tandem mass spectrometry (UHPLC-MS/MS). Results Nine hundred and sixty-four cases were included, 841 (87.2%) at the OAEOC and 123 (12.8%) at the OUH. A total of 55 oral fluid samples (OAEOC) and 103 blood samples (OUH) could be analysed. NPS were not clinically suspected in any of the screened cases. At the outpatient clinic, the most commonly found substances were clonazepam in 42/55 (76.4%) cases, amfetamines in 40/55 (72.7%) and heroin in 39/55 (70.9%). In seven (12.7%) cases NPS were detected: 4-methylamfetamine in three cases, dimethyltryptamine in two, methylone in one, and N,N-dimethyl-3,4-methylenedioxyamfetamine in one. Among the hospital patients, the most commonly found substances were clonazepam in 51/103 (49.5%) cases, amfetamines in 48/103 (46.6%), heroin in 31/103 (30.1%), and diazepam in 30/103 (29.1%). In five (4.9%) cases NPS were detected: JWH-210 in two cases, AM-2201 in two, and 5-EAPB in one. Conclusion NPS were clinically not suspected, though found in eight percent of cases. Still, the vast majority of patients treated for recreational drug toxicity in Oslo have taken classical drugs. Management of these patients should be based on their clinical condition. However, it is highly important to be alert to atypical presentations possibly resulting from unsuspected drugs. Full text available from: http://dx.doi.org/10.1080/15563650.2017.1312002

Synthetic cathinones in Southern Germany – characteristics of users, substance-patterns, co-ingestions, and complications Romanek K, Stenzel J, Schmoll S, Schrettl V, Geith S, Eyer F, Rabe C. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1301463: Objective To define the characteristics of synthetic cathinone users admitted to hospital including clinical and laboratory parameters and the complications of use. Design Retrospective single-center study of patients treated for acute cathinone intoxication and complications of cathinone use between January 2010 and January 2016.

Setting A specialized clinical toxicology unit at an academic tertiary care center in Southern Germany serving a population of about 4 million. Patients and methods 81 consecutive patients with laboratory-confirmed use of cathinones who presented for acute intoxication or complications of cathinone use were retrospectively analyzed. Results and conclusions The patients were predominantly male (64%, 52/81) with a median age of 34 years. 60 were admitted for signs of acute intoxication while 21 suffered from complications of cathinone use. 70% of acutely intoxicated patients had an increased creatinine phosphokinase. Only a minority of patients presented with a sympathomimetic toxidrome. Three patients had infectious complications, 10 prolonged psychosis, 6 rhabdomyolyses and/or kidney failure, and two patients died. Based on presentations, cathinone use has increased with the first cases seen in 2010. Opiates/opioids are the main co-ingested drugs of abuse. The pattern of cathinone use shifted from methylone in 2010/2011 to 3,4- methylenedioxypyrovalerone (MDPV) and 3-methylmethcathinone (3-MMC) in 2014/2015. We conclude that in our setting "typical" cathinone users are males in their thirties. They are seldom drug naive and regularly co-ingest illicit drugs. Preventive measures have to be tailored to these difficult to reach patients. Present efforts to educate young clubbers in their late teens may fail to reach the pertinent demographic. Full text available from: http://dx.doi.org/10.1080/15563650.2017.1301463

Intoxications involving acrylfentanyl and other novel designer fentanyls – results from the Swedish STRIDA project Helander A, Bäckberg M, Signell P, Beck O. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1303141: Background The number of new psychoactive substances (NPS) introduced through the online recreational drugs market increases continuously. This report from the Swedish STRIDA project describes analytically confirmed intoxications involving the novel fentanyl analogs acrylfentanyl, 4-chloroisobutyrfentanyl (4Cl-iBF), 4-fluoroisobutyrfentanyl (4F-iBF), and tetrahydrofuranfentanyl (THF-F), and cyclopentylfentanyl in a drug product. Methods Patients with suspected NPS exposure presenting in emergency departments (ED) or intensive care units (ICU) in Sweden and requiring hospital care are invited to the STRIDA project. NPS analysis of serum and urine samples was performed by multi-component liquid chromatography-mass spectrometry. Data on clinical features were retrieved from telephone consultations with the Swedish Poisons Information Centre and from medical records. Results Between April and October 2016, eleven intoxications involving acrylfentanyl (8 cases), acrylfentanyl together with 4Cl-iBF (1), 4F-iBF (1), and THF-F (1) were analytically confirmed. Patients were aged 19-51 (median 28) years and 91% were men. Six (55%) were monitored at the ED, and five admitted to the ICU. Typical clinical features were decreased consciousness, respiratory depression, and miosis. In 8 cases, the antidote naloxone was administered to counter the opioid effects. The 4F-iBF positive patient eventually died of brain edema. The serum acrylfentanyl concentration (n = 8) ranged 0.5– 2.1 (median 0.9) ng/mL, and in urine (n = 9) 0.2–10.5 (mean 4.6, median 5.2) g/mmol creatinine. For 4Cl-iBF, 4F-iBF, and THF-F (n = 1 each), higher serum (5–45 ng/mL) and urine (11–136 g/mmol creatinine) concentrations were found. Other NPS (e.g.,

flunitrazolam) and/or classical drugs were detected in five cases. In early 2016, nasal sprays with a claimed content of acrylfentanyl brought to hospital by patients or obtained by test purchase were demonstrated to instead contain fentanyl. Conclusions Potentially life-threatening opioid toxicity was seen in 11 acute intoxications involving the fentanyl analogs acrylfentanyl, 4Cl-iBF, 4F-iBF, and THF-F, which are available through open Internet trading. All patients were supported with acute and intensive hospital care, and naloxone was effective to reverse the opioid symptoms. One patient died of brain edema. Full text available from: http://dx.doi.org/10.1080/15563650.2017.1303141

Supraventricular tachycardia and acute confusion following ingestion of e-cigarette fluid containing AB-FUBINACA and ADB- FUBINACA: a case report with quantitative analysis of serum drug concentrations Lam RPK, Tang MHY, Leung SC, Chong YK, Tsui MSH, Mak TWL. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1307385: Background AB-FUBINACA and ADB-FUBINACA are structurally similar synthetic cannabinoids with potent CB1 receptor agonistic effects. Very little is known about their pharmacology and toxicology. Objective To report a case of supraventricular tachycardia and acute confusion after ingestion of e- cigarette fluid containing AB-FUBINACA and ADB-FUBINACA, with quantitative analysis of the serum drug concentrations. Case report A healthy 24-year-old man ingested two drops of e-cigarette fluid which were later found to contain AB-FUBINACA and ADB-FUBINACA. Within 30 min of ingestion, he became somnolent, confused, and agitated, with palpitation and vomiting. On arrival to the emergency department, a short run of supraventricular tachycardia was noted, which resolved spontaneously. Bedside urine immunoassay failed to detect recreational drugs. Laboratory blood tests showed mild hypokalemia. Exposure to AB-FUBINACA and ADB- FUBINACA was confirmed analytically, with serum concentrations of 5.6 ng/mL and 15.6 ng/mL, respectively, in the blood sample collected on presentation. The patient recovered uneventfully with supportive treatment and was discharged 22 h after admission. Discussion AB-FUBINACA and ADB-FUBINACA are orally bioavailable with rapid onset of toxicity after ingestion. In this case, supraventricular tachycardia was likely the result of exposure to AB- FUBINACA and ADB-FUBINACA. The serum concentrations of AB-FUBINACA and ADB- FUBINACA were higher than those previously reported in fatal cases. Conclusion In the context of acute poisoning, the presence of unexplained tachyarrhythmias, confusion, and a negative recreational drug screen should prompt clinicians to consider synthetic cannabinoid toxicity as a differential diagnosis. Full text available from: http://dx.doi.org/10.1080/15563650.2017.1307385

Serum S100 protein could predict altered consciousness in glyphosate or glufosinate poisoning patients Lee J-W, Choi Y-J, Park S, Gil H-W, Song H-Y, Hong S-Y. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1286013: Background Central nervous system (CNS) complications such as seizures and reduced consciousness are important in glufosinate and may occur in severe glyphosate poisoning. The aim of this study was to assess the possible role of serum S100B protein as a biochemical marker of CNS complications associated with glyphosate or glufosinate poisoning. Methods The study enrolled 40 patients (23 glyphosate poisoning and 17 glufosinate poisoning). Altered consciousness and seizure were observed during hospitalization. S100B level was measured with fully automated modular analytic E170 system using electrochemo- luminometric immunoassay. Results Among 40 patients, neurologic features were observed in 12 patients with a median time to onset of 21.5 (IQR 8.25–24.75) h. Serum S100B concentrations measured on admission were higher in the group with neurologic features than in the group without neurologic features [0.148 g/L (IQR 0.128–0.248) vs. 0.072 g/L (IQR 0.047–0.084), p < .001]. Univariate analysis of measured patient raw parameters using a ROC curve showed that S100B was a significant predictor of neurologic features in glyphosate and glufosinate poisoning. The area under the ROC curve was 0.894 (95% confidential interval 0.791– 0.998). When S100B was set at 0.0965, its sensitivity and specificity for predicting neurologic features in glyphosate and glufosinate poisoning were 92% and 82%, respectively. Conclusions In our pilot study, S100B was a significant predictor of neurologic complications in patients with glyphosate and glufosinate poisoning. Large prospective cohorts are needed to confirm this finding. Full text available from: http://dx.doi.org/10.1080/15563650.2017.1286013

Analysis of intentional drug poisonings using Ohio Poison Control Center Data, 2002–2014 Pringle K, Caupp S, Shi J, Wheeler KK, Spiller HA, Casavant MJ, Xiang H. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1309050: Context Pharmaceutical drug poisonings, especially those that are intentional, are a serious problem for adolescents and young adults. Poison control center data is a viable tool to track intentional drug poisonings in near real-time. Objective To determine intentional drug poisoning rates among adolescents and young adults in Ohio using poison control center data. Methods We analyzed data from 2002 to 2014 obtained by Ohio's three poison control centers. Inclusion variables were calls made to the centers that had appropriate subject age (10–29 years old), subject sex, involved substance (all drug classes), and medical outcome (no effect, minor effect, moderate effect, major effect, and death). Intentional drug poisoning

reports were also separated into subgroups to compare suspected suicide reports to misuse and abuse reports. Finally, resident population estimates were used to generate 2014 intentional drug poisoning rates for each county in Ohio. Results The most common age group for intentional drug poisonings was 18–24. Females reported more suspected suicide drug poisonings while males reported more misuse/abuse drug poisonings. The most reported drug class across all ages was analgesics. Of the 88 counties in Ohio, Hamilton, Williams, Washington, and Guernsey counties had the highest rates of intentional drug poisonings. Conclusions The high report rate of suspected suicides and analgesic class drugs demonstrates the need for preventative measures for adolescents and young adults in Ohio. Any interventions, along with legislative changes, will need to take place in our local communities. Full text available from: http://dx.doi.org/10.1080/15563650.2017.1309050

Cost-effectiveness of hospital treatment and outcomes of acute methanol poisoning during the Czech Republic mass poisoning outbreak Rulisek J, Balik M, Polak F, Waldauf P, Pelclova D, Belohlavek J, Zakharov S. J Crit Care 2017; online early: doi: 10.1016/j.jcrc.2017.03.001: Abstract and full text available from: http://dx.doi.org/10.1016/j.jcrc.2017.03.001

Suicide prevention through means restriction: Impact of the 2008-2011 pesticide restrictions on suicide in Sri Lanka Knipe DW, Chang S-S, Dawson A, Eddleston M, Konradsen F, Metcalfe C, Gunnell D. PLoS ONE 2017; 12: e0172893. Abstract and full text available from: http://dx.doi.org/10.1371/journal.pone.0172893

Should we be using the Poisoning Severity Score? Schwarz ES, Kopec KT, Wiegand TJ, Wax PM, Brent J. J Med Toxicol 2017; online early: doi: 10.1007/s13181-017-0609-5: Abstract and full text available from: http://dx.doi.org/10.1007/s13181-017-0609-5

An updated review of ciguatera fish poisoning: clinical, epidemiological, environmental, and public health management Friedman MA, Fernandez M, Backer LC, Dickey RW, Bernstein J, Schrank K, Kibler S, Stephan W, Gribble MO, Bienfang P, Bowen RE, Degrasse S, Flores Quintana HA, Loeffler CR, Weisman R, Blythe D, Berdalet E, Ayyar R, Clarkson-Townsend D, Swajian K, Benner R, Brewer T, Fleming LE. Mar Drugs 2017; 15: 72. Abstract and full text available from: http://dx.doi.org/10.3390/md15030072

Oral chemical burns reported to the poisons information centre in Erfurt, Germany, from 1997 to 2014 Nehrlich J, Klöcking H-P, Hentschel H, Lupp A. J Burn Care Res 2017; online early: doi: 10.1097/BCR.0000000000000518: Abstract and full text available from: http://dx.doi.org/10.1097/BCR.0000000000000518

A critical review of the relationship between occupational exposure to diesel emissions and lung cancer risk Möhner M, Wendt A. Crit Rev Toxicol 2017; 47: 185-224. Abstract and full text available from: http://dx.doi.org/10.1080/10408444.2016.1266598

Availability and cost of extracorporeal treatments for poisonings and other emergency indications: a worldwide survey Bouchard J, Lavergne V, Roberts DM, Cormier M, Morissette G, Ghannoum M. Nephrol Dial Transplant 2017; 32: 699-706. Abstract and full text available from: http://dx.doi.org/10.1093/ndt/gfw456

Real-world use of idarucizumab for dabigatran reversal in three cases of serious bleeding Gendron N, Feral-Pierssens AL, Jurcisin I, de Raucourt E, Bouton V, Fischer AM, Lorenceau-Savale C, Lillo-Le Louët A, Smadja DM. Clin Case Rep 2017; 5: 346-50. Abstract and full text available from: http://dx.doi.org/10.1002/ccr3.839

Maternal exposure to domestic hair cosmetics and occupational endocrine disruptors is associated with a higher risk of hypospadias in the offspring Haraux E, Braun K, Buisson P, Stéphan-Blanchard E, Devauchelle C, Ricard J, Boudailliez B, Tourneux P, Gouron R, Chardon K. Int J Environ Res Public Health 2017; 14: 27. Abstract and full text available from: http://dx.doi.org/10.3390/ijerph14010027

Maternal exposure to pyrethroid insecticides during pregnancy and infant development at 18 months of age Hisada A, Yoshinaga J, Zhang J, Kato T, Shiraishi H, Shimodaira K, Okai T, Ariki N, Komine Y, Shirakawa M, Noda Y, Kato N. Int J Environ Res Public Health 2017; 14: 52.

Abstract and full text available from: http://dx.doi.org/10.3390/ijerph14010052

Validated method for the screening and quantification of TOXICOLOGY baclofen, gabapentin and pregabalin in human post- General mortem whole blood using protein precipitation and liquid McFarland SE, Bronstein AC, Banerji S, LeBlond J, Mischke chromatography-tandem mass spectrometry. RH, Begemann K, Desel H, Greiner M. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx019: Comparison of the Poisoning Severity Score and National Poison Data System schemes for the severity assessment Neves JF, Alves EA, Soares JX, Cravo SM, Silva AMS, Pereira of animal poisonings: a pilot study. Netto AD, Carvalho F, Dinis-Oliveira RJ, Afonso CM. Clin Toxicol 2017; online early: Data analysis of "krokodil" samples obtained by street-like doi: 10.1080/15563650.2017.1304554: synthesis. Data Brief 2016; 6: 83-8. Schwarz ES, Kopec KT, Wiegand TJ, Wax PM, Brent J. Should we be using the poisoning severity score? Poklis JL, Wolf CE, II, Peace MR. J Med Toxicol 2017; online early: doi: 10.1007/s13181- Ethanol concentration in 56 refillable electronic cigarettes 017-0609-5: liquid formulations determined by headspace gas chromatography with flame ionization detector (HS-GC-FID). Drug Test Anal 2017; online early: doi: 10.1002/dta.2193: Analytical toxicology Bishop-Freeman SC, Shonsey EM, Friederich LW, Beuhler Ponzetto F, Boccard J, Baume N, Kuuranne T, Rudaz S, MC, Winecker RE. Saugy M, Nicoli R. Benzonatate toxicity: nothing to cough at. High-resolution mass spectrometry as an alternative J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx021: detection method to tandem mass spectrometry for the analysis of endogenous steroids in serum. Carlier J, Diao X, Scheidweiler KB, Huestis MA. J Chromatogr B Biomed Sci Appl 2017; 1052: 34-42. Distinguishing intake of new synthetic cannabinoids ADB- PINACA and 5F-ADB-PINACA with human hepatocyte Rai S, Gullapalli MD, Srivastava A, Shaik H, Siddiqui MH, metabolites and high-resolution mass spectrometry. Mudiam MK. Clin Chem 2017; online early: A rapid method for the quantitative determination of 34 doi: 10.1373/clinchem.2016.267575: pesticides in nonalcoholic carbonated beverages using liquid-liquid extraction coupled to dispersive solid-phase Fort C, Jourdan T, Kemp J, Curtis B. cleanup followed by gas chromatography with tandem Stability of synthetic cannabinoids in biological specimens: mass spectrometry. analysis through liquid chromatography tandem mass J AOAC Int 2017; online early: doi: 10.5740/jaoacint.17- spectrometry. 0064: J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx015: Sadler Simões S, Castañera Ajenjo A, Dias MJ. Gao X, Tan Y, Guo H. Dried blood spots combined to an UPLC-MS/MS method Simultaneous determination of amitraz, chlordimeform, for the simultaneous determination of drugs of abuse in formetanate and their main metabolites in human urine by forensic toxicology. high performance liquid chromatography-tandem mass J Pharm Biomed Anal 2017; online early: spectrometry. doi: 10.1016/j.jpba.2017.02.046: J Chromatogr B Biomed Sci Appl 2017; 1052: 27-33. Salomone A, Palamar JJ, Gerace E, Di Corcia D, Vincenti M. Gracia MS, Köppl A, Unholzer S, Haen E. Hair testing for drugs of abuse and new psychoactive substances in a high-risk population. Development and validation of a HPLC-UV method for the J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx020: simultaneous determination of the antipsychotics clozapine, olanzapine and quetiapine, several beta- Sanna T, Olof B, Tessa B, Michaela B, Duncan C, Nadia F, blockers and their metabolites. Claire G, Mark P, Alberto S, Wim S, Stefan S, Wolfgang W. Biomed Chromatogr 2017; online early: European guidelines for workplace drug testing in urine. doi: 10.1002/bmc.3968: Drug Test Anal 2017; online early: doi: 10.1002/dta.2178:

Jones AW. Scherer JN, Fiorentin TR, Sousa TR, Limberger RP, Review of caffeine-related fatalities along with postmortem Pechansky F. blood concentrations in 51 poisoning deaths. Oral fluid testing for cocaine: analytical evaluation of two J Anal Toxicol 2017; 41: 161-72. point-of-collection drug screening devices. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx018: Liu C-C, Liu S-L, Xi H-L, Yu H-L, Zhou S-K, Huang G-L, Liang L-H, Liu J-Q. Tomková J, Švidrnoch M, Maier V, Ondra P. Simultaneous quantification of four metabolites of sulfur Analysis of selected designer benzodiazepines by UHPLC mustard in urine samples by ultra-high performance liquid with high-resolution time-of-flight mass spectrometry and chromatography-tandem mass spectrometry after solid the estimation of their partition coefficients by micellar phase extraction. electrokinetic chromatography. J Chromatogr A 2017; 1492: 41-8. J Sep Sci 2017; online early: doi: 10.1002/jssc.201700069:

McGonigal MK, Wilhide JA, Smith PB, Elliott NM, Dorman FL. Veiga-Gómez M, Nebot C, Franco CM, Miranda JM, Analysis of synthetic phenethylamine street drugs using Vázquez B, Cepeda A. direct sample analysis coupled to accurate mass time of Identification and quantification of 12 pharmaceuticals in flight mass spectrometry. water collected from milking parlors: food safety im- Forensic Sci Int 2017; 275: 83-9. plications. J Dairy Sci 2017; online early: doi: 10.3168/jds.2016- Nahar L, Smith A, Patel R, Andrews R, Paterson S. 12227:

Yan H, Xiang P, Zhang S, Shen B, Shen M. Munta K, Santosh P, Surath MR. Diagnosis of aluminum phosphide poisoning using a new Severe hypothermia causing ventricular arrhythmia in analytical approach: forensic application to a lethal organophosphorus poisoning. intoxication. Indian J Crit Care Med 2017; 21: 99-101. Int J Legal Med 2017; online early: doi: 10.1007/s00414- 017-1562-1: Nattel S. An emerging malignant arrhythmia epidemic due to Biomarkers loperamide abuse: underlying mechanisms and clinical Zhang X, Zhang C-H, Zheng J, Li L-X, Geng T-Q, Zhang Y. relevance. Potential biomarkers for monitoring the toxicity of long- JACC Clin Electrophysiol 2016; 2: 790-2. term exposure to atrazine in rat by metabonomic analysis. Xenobiotica 2017; online early: Nocera M. doi: 10.1080/00498254.2017.1303221: A teenage girl with altered mental status and sinus tachycardia. Carcinogenicity Clin Pediatr Emerg Med 2016; 17: 312-6. Boffetta P, Fordyce TA, Mandel JS. A mortality study of beryllium workers. Quan D, Zurcher K. Cancer Med 2016; 5: 3596-605. Reversible atrial fibrillation following Crotalinae envenomation. Möhner M, Wendt A. J Venom Anim Toxins Incl Trop Dis 2017; 23: 16. A critical review of the relationship between occupational exposure to diesel emissions and lung cancer risk. Reece AS, Norman A, Hulse GK. Crit Rev Toxicol 2017; 47: 185-224. Acceleration of cardiovascular-biological age by amphetamine exposure is a power function of chronological age. Niaz K, Maqbool F, Khan F, Bahadar H, Ismail Hassan F, Heart Asia 2017; 9: 30-8. Abdollahi M. Smokeless tobacco (paan and gutkha) consumption and Salehi F, Hassanzadeh Taheri MM, Riasi H, Mehrpour O. its prevalence contributing toward oral cancer. Recurrent syncope following substance abuse; a case Epidemiol Health 2017; online early: report. doi: 10.4178/epih.e2017009: Emergency 2017; 5: e47.

Qayyum MA, Shah MH. Schröder J, Hamada S, Altiok E, Almalla M, Koutziampasi Study of trace metal imbalances in the blood, scalp hair C, Napp A, Keszei A, Hein M, Becker M. and nails of oral cancer patients from Pakistan. Detection of acute changes in left ventricular function by Sci Total Environ 2017; 593-594: 191-201. myocardial deformation analysis after excessive alcohol ingestion. Cardiotoxicity J Am Soc Echocardiogr 2017; 30: 235-43.e1. Benowitz NL, Fraiman JB. Cardiovascular effects of electronic cigarettes. Shattuck B, Livingstone J. Nat Rev Cardiol 2017; online early: A case of cardiac tamponade due to an isolated abscess in doi: 10.1038/nrcardio.2017.36: the ascending aorta of a pregnant woman with a history of intravenous substance abuse. Bhatti Z, Norsworthy J, Szombathy T. Forensic Sci Med Pathol 2017; online early: Loperamide metabolite-induced cardiomyopathy and QTc doi: 10.1007/s12024-017-9856-7: prolongation. Clin Toxicol 2017; online early: Stolk LM, De Vries F, Ebbelaar C, de Boer A, Schalekamp doi: 10.1080/15563650.2017.1304555: T, Souverein P, Ten Cate-Hoek A, Burden AM. Risk of myocardial infarction in patients with atrial Dadpour B, Gholoobi A, Tajoddini S, Habibi A. fibrillation using vitamin K antagonists, aspirin or direct Acute myocardial infarction following naltrexone consumption; acting oral anticoagulants. a case report. Br J Clin Pharmacol 2017; online early: Emergency 2017; 5: e45. doi: 10.1111/bcp.13264:

Lam RPK, Tang MHY, Leung SC, Chong YK, Tsui MSH, Turillazzi E, Cerretani D, Cantatore S, Fiaschi AI, Frati P, Mak TWL. Micheli L, Neri M, Cipolloni L, Di Paolo M, Pinchi E, Riezzo Supraventricular tachycardia and acute confusion following I, Santurro A, Vullo A, Fineschi V. ingestion of e-cigarette fluid containing AB-FUBINACA and Myocardial oxidative damage is induced by cardiac Fas- ADB-FUBINACA: a case report with quantitative analysis of dependent and mitochondria-dependent apoptotic pathways serum drug concentrations. in human cocaine-related overdose. Clin Toxicol 2017; online early: Sci Rep 2017; 7: 44262. doi: 10.1080/15563650.2017.1307385: Yanamandra U, Gupta S, Khadwal A, Malhotra P. Mattioli AV, Pennella S, Manenti A, Farinetti A. Melphalan-induced cardiotoxicity: ventricular arrhythmias. Energy drink overconsumption can trigger atrial fibrillation. BMJ Case Rep 2016; doi: 10.1136/bcr-2016-218652: J Cardiovasc Med 2016; 17: 902-4.

Montague AJ, Bangh S, Cole JB. Dermal toxicity Bradycardia in a child after using brimonidine as toothpaste. Colomb S, Bourrain JL, Bonardel N, Chiriac A, Demoly P. JAMA Dermatol 2017; online early: Occupational opiate contact dermatitis. doi: 10.1001/jamadermatol.2016.6215: Contact Derm 2017; 76: 240-1.

Desmedt B, Courselle P, De Beer JO, Rogiers V, Grosber Oliveira C, Joshee L, George H, Nijhara S, Bridges C. M, Deconinck E, De Paepe K. Oral exposure of pregnant rats to toxic doses of Overview of skin whitening agents with an insight into the methylmercury alters fetal accumulation. illegal cosmetic market in Europe. Reprod Toxicol 2017; 69: 265-75. J Eur Acad Dermatol Venereol 2016; 30: 943-50. Sun Y, Li Y-S, Li B, Ma K, Li B-X. Lynn DD, Zukin LM, Dellavelle R. A study of the age-related effects of lactational atrazine The safety and efficacy of Diphoterine for ocular and exposure. cutaneous burns in humans. Reprod Toxicol 2017; 69: 230-41. Cutan Ocul Toxicol 2017; 36: 185-92. Weller A, Daniel S, Koren G, Lunenfeld E, Levy A. Maina G, Castagnoli C, Ghione G, Passini V, Adami G, The fetal safety of clomiphene citrate: a population based Larese Filon F, Crosera M. retrospective cohort study. Skin contamination as pathway for nicotine intoxication in Br J Obstet Gynaecol 2017; online early: vapers. doi: 10.1111/1471-0528.14651: Toxicol In Vitro 2017; 41: 102-5.

Serup J. Driving under the influence of alcohol How to diagnose and classify tattoo complications in the and other drugs clinic: a system of distinctive patterns. Bombana HS, Gjerde H, dos Santos MF, Jamt REG, Curr Probl Dermatol 2017; 52: 58-73. Yonamine M, Rohlfs WJC, Muñoz DR, Leyton V. Prevalence of drugs in oral fluid from truck drivers in Serup J. Brazilian highways. From technique of tattooing to biokinetics and toxicology Forensic Sci Int 2017; 273: 140-3. of injected tattoo ink particles and chemicals. Curr Probl Dermatol 2017; 52: 1-17. Rajotte JW, Palmentier J-PFF, Wallage HR. Drug recognition evaluation and chemical confirmation of Signore RJ. a 25C-NBOMe-impaired driver. Prevention of poison ivy dermatitis with oral homeopathic J Forensic Sci 2017; online early: doi: 10.1111/1556- Rhus toxicodendron. 4029.13433: Dermatol Online J 2017; 23: 17. Razvodovsky YE. Slaughter RJ, Beasley MG, Schep LJ. Fatal alcohol poisonings and traffic accidents in Russia. Dermatitis due to Toxicodendron plants: a common occur- Alcohol Psychiatry Res 2016; 52: 115-24. rence during autumn. N Z Med J 2017; 130: 82-3. Epidemiology Vanhoucke J, Buylaert W, Colpaert K, De Paepe P. Anon. Ingestion of white spirit resulting in perineal skin burns: a Number of deaths resulting from unintentional carbon case report and review of the literature. monoxide poisoning,* by month and year - National Vital Acta Clin Belg 2017; online early: Statistics System, United States, 2010-2015. doi: 10.1080/17843286.2017.1290190: MMWR Morb Mortal Wkly Rep 2017; 66: 234.

Developmental toxicology Allen JD, Casavant MJ, Spiller HA, Chounthirath T, Hodges NL, Smith GA. Haraux E, Braun K, Buisson P, Stéphan-Blanchard E, Prescription opioid exposures among children and ado- Devauchelle C, Ricard J, Boudailliez B, Tourneux P, Gouron lescents in the United States: 2000 2015. R, Chardon K. – Pediatrics 2017; online early: doi: 10.1542/peds.2016- Maternal exposure to domestic hair cosmetics and 3382: occupational endocrine disruptors is associated with a higher risk of hypospadias in the offspring. Int J Environ Res Public Health 2017; 14: 27. Bakalli I, Celaj E, Kola E, Sala D, Lluka R, Gjeta I, Sallabanda S. Hisada A, Yoshinaga J, Zhang J, Kato T, Shiraishi H, Pattern of acute poisoning among children in Albania. Shimodaira K, Okai T, Ariki N, Komine Y, Shirakawa M, Noda Eur J Pediatr 2016; 175: 1561-2. Y, Kato N. Maternal exposure to pyrethroid insecticides during Bouziri A, Loueti A, Ayari A, Narjess G, Khaldi A, Menif K, pregnancy and infant development at 18 months of age. Borgi A, Ben Jaballah N. Int J Environ Res Public Health 2017; 14: 52. Acute severe poisoning in a pediatric intensive care unit: the experience of a single-center over a period of 14 Jacobs M, Zhang G, Chen S, Mullins B, Bell M, Jin L, Guo years. Y, Huxley R, Pereira G. Eur J Pediatr 2016; 175: 1461-2. The association between ambient air pollution and selected adverse pregnancy outcomes in China: a systematic review. Bukten A, Stavseth MR, Skurtveit S, Tverdal A, Strang J, Sci Total Environ 2017; 579: 1179-92. Clausen T. High risk of overdose death following release from prison: Miller MM, Meyer AE, Sprowles JL, Sable HJ. Variations in mortality during a 15-year observation Cocaine self-administration in male and female rats period. perinatally exposed to PCBs: evaluating drug use in an Addiction 2017; online early: doi: 10.1111/add.13803: animal model of environmental contaminant exposure. Exp Clin Psychopharmacol 2017; online early: Chang C, Chen M, Gao J, Luo J, Wu K, Dong T, Zhou K, He doi: 10.1037/pha0000113: X, Hu W, Wu W, Lu C, Hang B, Meeker JD, Wang X, Xia Y.

Current pesticide profiles in blood serum of adults in Exploring complexity of deliberate self-poisoning through Jiangsu Province of China and a comparison with other network analysis. countries. Psychiatry J 2017; 2017: 3619721. Environ Int 2017; online early: doi: 10.1016/j.envint.2017.03.004: López-Rodríguez G, Galván M, González-Unzaga M, Hernández Ávila J, Pérez-Labra M. Chauhan V, Thakur S. Blood toxic metals and hemoglobin levels in Mexican The North-South divide in snake bite envenomation in children. India. Environ Monit Assess 2017; 189: 179. J Emerg Trauma Shock 2016; 9: 151-4. Masters RK, Tilstra AM, Simon DH. Dadpour B, Tajoddini S, Rajabi M, Afshari R. Mortality from suicide, chronic liver disease, and drug Mushroom poisoning in the northeast of Iran; a retro- poisonings among middle-aged U.S.white men and women, spective 6-year epidemiologic study. 1980–2013. Emergency 2017; 5: e23. Biodemography Soc Biol 2017; 63: 31-7.

Das Adhikari D, Das S, Winston AB, Vazhudhi K, Kumar A, Mercado MC, Sumner SA, Spelke MB, Bohm MK, Sugerman Shanthi M, Agarwal I. DE, Stanley C. A retrospective study on non-drug related poisoning in the Increase in drug overdose deaths involving fentanyl— community among children from south India. Rhode Island, January 2012–March 2014. Hosp Pract (1995) 2017; online early: Pain Med 2017; online early: doi: 10.1093/pm/pnx015: doi: 10.1080/21548331.2017.1303326: Naz S, Page A, Agho KE. De Almeida Lopes ACB, Silbergeld EK, Navas-Acien A, Household air pollution and under-five mortality in India Zamoiski R, Martins AdC, Jr., Camargo AEI, Urbano MR, (1992–2006). Mesas AE, Paoliello MMB. Environ Health 2016; 15: 54. Association between blood lead and blood pressure: a population-based study in Brazilian adults. Nehrlich J, Klöcking H-P, Hentschel H, Lupp A. Environ Health 2017; 16: 27. Oral chemical burns reported to the poisons information centre in Erfurt, Germany, from 1997 to 2014. Friedman MA, Fernandez M, Backer LC, Dickey RW, Bernstein J Burn Care Res 2017; online early: J, Schrank K, Kibler S, Stephan W, Gribble MO, Bienfang P, doi: 10.1097/BCR.0000000000000518: Bowen RE, Degrasse S, Flores Quintana HA, Loeffler CR, Weisman R, Blythe D, Berdalet E, Ayyar R, Clarkson- Nouhjah S, Kalhori SRN, Saki A. Townsend D, Swajian K, Benner R, Brewer T, Fleming LE. Risk factors of non-fatal unintentional home injuries among An updated review of ciguatera fish poisoning: clinical, children under 5 years old; a population-based study. epidemiological, environmental, and public health man- Emergency 2017; 5: e6. agement. Mar Drugs 2017; 15: 72. Okumura Y, Sakata N, Takahashi K, Nishi D, Tachimori H. Epidemiology of overdose episodes from the period prior Gaither JR, Leventhal JM, Ryan SA, Camenga DR. to hospitalization for drug poisoning until discharge in National trends in hospitalizations for opioid poisonings Japan: an exploratory descriptive study using a nationwide among children and adolescents, 1997 to 2012. claims database. JAMA Pediatr 2016; 170: 1195-201. J Epidemiol 2017; online early: doi: 10.1016/j.je.2016.08.010: Hassanian-Moghaddam H, Hakiminejhad M, Farnaghi F, Mirafzal A, Zamani N, Kabir A. Pillans PI, Page CB, Ilango S, Kashchuk A, Isbister GK. Eleven years of children methadone poisoning in a referral Self-poisoning by older Australians: a cohort study. center: a review of 453 cases. Med J Aust 2017; 206: 164-9. J Opioid Manag 2017; 13: 27-36. Pringle K, Caupp S, Shi J, Wheeler KK, Spiller HA, Hedegaard H, Warner M, Minino AM. Casavant MJ, Xiang H. Drug overdose deaths in the United States, 1999-2015. Analysis of intentional drug poisonings using Ohio Poison NCHS Data Brief 2017; 1-8. Control Center Data, 2002–2014. Clin Toxicol 2017; online early: Hernández AF, Tsatsakis AM. doi: 10.1080/15563650.2017.1309050: Human exposure to chemical mixtures: Challenges for the integration of toxicology with epidemiology data in risk Rausch C, Laflamme L, Bültmann U, Möller J. assessment. Number of medications and adverse drug events by Food Chem Toxicol 2017; 103: 188-93. unintentional poisoning among older adults in consideration of inappropriate drug use: a Swedish population-based Ho JY. matched case-control study. The contribution of drug overdose to educational gradients Eur J Clin Pharmacol 2017; online early: in life expectancy in the United States, 1992–2011. doi: 10.1007/s00228-017-2220-8: Demography 2017; online early: doi: 10.1007/s13524- 017-0565-3: Shokrzadeh M, Hoseinpoor R, Hajimohammadi A, Delaram A, Shayeste Y. Hopwood MJ. Epidemiological survey of suicide attempt by drug Self-poisoning by older Australians. poisoning in Gorgan, Iran, 2008 to 2015. Med J Aust 2017; 206: 161-2. J Mazandaran Univ Med Sci 2016; 26: 201-10.

Kalankesh LR, Farahbakhsh M, Fein RA, Moftian N, Nasiry Z. Welton R, Liew D, Braitberg G.

Incidence of fatal snake bite in Australia: A coronial based Review of caffeine-related fatalities along with postmortem retrospective study (2000–2016). blood concentrations in 51 poisoning deaths. Toxicon 2017; 131: 11-5. J Anal Toxicol 2017; 41: 161-72.

Forensic toxicology Kapitány-Fövény M, Zacher G, Posta J, Demetrovics Z. Ali SS, Karunakar B, Khan MT. GHB-involved crimes among intoxicated patients. Histopathological study of hepatorenopulmonary changes Forensic Sci Int 2017; 275: 23-9. in deaths due to organophosphorus poisoning. Indian J Forensic Med Toxicol 2017; 11: 96-100. Mathur RK, Singh S, Srivastava A, Meena KK. Medico-legal study on the poisoning cases of Ajmer region. Bjune T, Risgaard B, Kruckow L, Glinge C, Ingemann- Indian J Forensic Med Toxicol 2017; 11: 27-32. Hansen O, Leth PM, Linnet K, Banner J, Winkel BG, Tfelt- Hansen J. Matsusue A, Ishikawa T, Michiue T, Waters B, Hara K, Post-mortem toxicology in young sudden cardiac death Kashiwagi M, Takayama M, Ikematsu N, Kubo S-I. victims: a nationwide cohort study. Association between cerebrospinal fluid dopamine Europace 2017; online early: concentrations and catechol-O-methyltransferase gene doi: 10.1093/europace/euw435: polymorphisms in forensic autopsy cases of methamphetamine abusers. Bombana HS, Gjerde H, dos Santos MF, Jamt REG, Forensic Sci Int 2017; 270: 159-64. Yonamine M, Rohlfs WJC, Muñoz DR, Leyton V. Prevalence of drugs in oral fluid from truck drivers in McGonigal MK, Wilhide JA, Smith PB, Elliott NM, Dorman FL. Brazilian highways. Analysis of synthetic phenethylamine street drugs using Forensic Sci Int 2017; 273: 140-3. direct sample analysis coupled to accurate mass time of flight mass spectrometry. Busardò FP, Pichini S. Forensic Sci Int 2017; 275: 83-9. The everlasting issue of GHB cut-offs in biological samples: how important it is to be careful when interpreting values. Neavyn MJ, Stolbach A, Greer DM, Nelson LS, Smith SW, Forensic Sci Int 2017; online early: Brent J, Tormoehlen LM, On behalf of the American doi: 10.1016/j.forsciint.2017.02.022: College of Medical Toxicology. ACMT position statement: determining brain death in Byard RW, Kenneally M. adults after drug overdose. Body pushing, prescription drugs and hospital admission. J Med Toxicol 2017; online early: doi: 10.1007/s13181- Forensic Sci Med Pathol 2017; online early: 017-0606-8: doi: 10.1007/s12024-017-9855-8: Rajotte JW, Palmentier J-PFF, Wallage HR. Chen HI-H, deJong J. Drug recognition evaluation and chemical confirmation of Increased lung weights in drug-related fatalities. a 25C-NBOMe-impaired driver. J Forensic Sci 2017; online early: J Forensic Sci 2017; online early: doi: 10.1111/1556- doi: 10.1111/1556-4029.13452: 4029.13433:

Devnath GP, Kumaran S, Rajiv R, Shaha KK, Nagaraj A. Rathod AL, Garg RK. Fatal folic acid toxicity in humans. Chlorpyrifos poisoning and its implications in human fatal J Forensic Sci 2017; online early: cases: a forensic perspective with reference to Indian doi: 10.1111/1556-4029.13489: scenario.

J Forensic Leg Med 2017; 47: 29-34. Diao X, Carlier J, Zhu M, Pang S, Kronstrand R,

Scheidweiler KB, Huestis MA. Sadler Simões S, Castañera Ajenjo A, Dias MJ. In vitro and in vivo human metabolism of a new synthetic Dried blood spots combined to an UPLC-MS/MS method cannabinoid NM-2201 (CBL-2201). for the simultaneous determination of drugs of abuse in Forensic Toxicol 2017; 35: 20-32. forensic toxicology.

J Pharm Biomed Anal 2017; online early: Fais P, Pigaiani N, Cecchetto G, Montisci M, Gottardo R, Viel G, Pascali JP, Tagliaro F. doi: 10.1016/j.jpba.2017.02.046: "Tampering to death": A fatal codeine intoxication due to a homemade purification of a medical formulation. Subhedar A, Karunaker B, Surendar J. J Forensic Sci 2017; online early: doi: 10.1111/1556- Comprehensive study of suicidal deaths due to insecticidal 4029.13492: poisons in females. Indian J Forensic Med Toxicol 2017; 11: 10-2. Hemanth Kumar RG, Pramod Kumar GN, Kotabagi RB. Profile of poisoning cases and related medicolegal time Suzuki H, Hasegawa I, Mishima S, Fukunaga T. frame. An autopsy case of fatal water intoxication with postmortem Indian J Forensic Med Toxicol 2017; 11: 81-3. computed tomography findings of diluted intestinal content and hemodilution. Johansson A, Lindstedt D, Roman M, Thelander G, Nielsen J Forensic Radiol Imaging 2016; 7: 43-6. EI, Lennborn U, Sandler H, Rubertsson S, Ahlner J, Kronstrand R, Kugelberg FC. Yan H, Xiang P, Zhang S, Shen B, Shen M. A non-fatal intoxication and seven deaths involving the Diagnosis of aluminum phosphide poisoning using a new dissociative drug 3-MeO-PCP. analytical approach: forensic application to a lethal Forensic Sci Int 2017; 275: 76-82. intoxication. Int J Legal Med 2017; online early: doi: 10.1007/s00414- Jones AW. 017-1562-1:

Genotoxicity Case Reports Hepatol 2017; 2017: 3864236. Rusiecki JA, Beane Freeman LE, Bonner MR, Alexander M, Chen L, Andreotti G, Barry KH, Moore LE, Byun H-M, Orbach SM, Cassin ME, Ehrich MF, Rajagopalan P. Kamel F, Alavanja M, Hoppin JA, Baccarelli A. Investigating acetaminophen hepatotoxicity in multi- High pesticide exposure events and DNA methylation cellular organotypic liver models. among pesticide applicators in the agricultural health study. Toxicol In Vitro 2017; online early: Environ Mol Mutagen 2017; 58: 19-29. doi: 10.1016/j.tiv.2017.03.008:

Roy-Chowdhury J, Roy-Chowdhury N, Listowsky I, Hepatotoxicity Wolkoff AW. Grama A, Bizo A, Delean D, Aldea C, Pop TL. Drug- and drug abuse–associated hyperbilirubinemia: Drug-induced acute liver failure in children. experience with atazanavir. Eur J Pediatr 2016; 175: 1738. Clin Pharmacol Drug Dev 2017; 6: 140-6.

Grama A, Bizo A, Delean D, Aldea C, Stefanescu A, Pop TL. Salmerón-Fernández MJ, Urrutia-Maldonado E, Abril- Treatment of acute liver failure caused by mushroom Molina A, Martín-García JA, Ales-Palmer ML, Gomez-Luque poisoning in children. JM, Martin-Massot R, Osorio-Camara JM, Ocete-Hita E. Eur J Pediatr 2016; 175: 1738. Ibuprofen-induced hepatotoxicity in paediatric population. Eur J Pediatr 2016; 175: 1620. Grasso IA, Blattner MR, Short T, Downs JW. Severe systemic lead toxicity resulting from extra-articular Thomas B, Mohamed M, Al HM, Awwad FAY, Wahba RM, retained shrapnel presenting as jaundice and hepatitis: a Hassan SB, Omar K, El KW, Rouf PA. case report and review of the literature. A case of probable esomeprazole-induced transient liver Mil Med 2017; 182: e1843-e1848. injury in a pregnant woman with hyperemesis. Clin Pharmacol 2016; 8: 199-202. Gupte-Singh K, Li H, Swain JL, Cheng Y, Regev A. Assessment of a severity-based algorithm to detect signals Yang L-X, Liu C-Y, Zhang L-L, Lai L-L, Fang M, Zhang C. of severe drug-induced liver injury using spontaneous Clinical characteristics of patients with drug-induced liver reporting database. injury. Pharmaceut Med 2017; 31: 41-51. Chin Med J (Engl ) 2017; 130: 160-4.

Hunt CM, Papay JI, Stanulovic V, Regev A. Yoshioka H, Nonogaki T, Fukuishi N, Shinohara Y, Hwang Drug rechallenge following drug-induced liver injury. G-W, Ohtani K, Miura N. Hepatology 2017; online early: doi: 10.1002/hep.29152: Chronotoxicity of bromobenzene-induced hepatic injury in

mice. Jiang L, Ke M, Yue S, Xiao W, Yan Y, Deng X, Ying Q-L, Li J Toxicol Sci 2017; 42: 251-8. J, Ke B.

Blockade of Notch signaling promotes acetaminophen- induced liver injury. Inhalation toxicity Immunol Res 2017; online early: doi: 10.1007/s12026- Al-Sawalha NA, Migdadi AM, Alzoubi KH, Khabour OF, 017-8913-3: Qinna NA. Effect of waterpipe tobacco smoking on airway inflam- Kullak-Ublick GA, Andrade RJ, Merz M, End P, Benesic A, mation in murine model of asthma. Gerbes AL, Aithal GP. Inhal Toxicol 2017; 29: 46-52. Drug-induced liver injury: recent advances in diagnosis and risk assessment. Be'eri E, Owen S, Shachar M, Barlavie Y, Eisenkraft A. Gut 2017; online early: doi: 10.1136/gutjnl-2016-313369: Impact of adding a filter for protection from toxic inhalational compounds to the ventilation circuit of Lee M-R, Lim Y-H, Lee B-E, Hong Y-C. mechanically ventilated patients. Blood mercury concentrations are associated with decline Disaster Mil Med 2016; 2: 3. in liver function in an elderly population: a panel study. Environ Health 2017; 16: 17. Butenhoff JL, Olsen GW, Chang S. Toxicological response of Sprague Dawley rats from Lisi DM. inhalation exposure to perfluorooctane sulfonyl fluoride Drug-induced liver injury: an overview. (POSF). US Pharm 2016; 41: 30-4. Toxicol Lett 2017; 271: 38-49.

Lunsford KE, Bodzin AS, Reino DC, Wang HL, Busuttil RW. Jain R, Verma A. Dangerous dietary supplements: Garcinia cambogia- Laboratory approach for diagnosis of toluene-based associated hepatic failure requiring transplantation. inhalant abuse in a clinical setting. World J Gastroenterol 2016; 22: 10071-6. J Pharm Bioallied Sci 2016; 8: 18-22.

Mallet M, Haq M, Tripon S, Bernard M, Benosman H, Tucci JR, Whitford GM, McAlister WH, Novack DV, Mumm Thabut D, Rudler M. S, Keaveny TM, Whyte MP. Elevated procalcitonin is associated with bacterial infection Skeletal fluorosis due to inhalation abuse of a during acute liver failure only when unrelated to difluoroethane-containing computer cleaner. acetaminophen intoxication. J Bone Miner Res 2016; 32: 188-95. Eur J Gastroenterol Hepatol 2017; online early: doi: 10.1097/MEG.0000000000000862: Van den Kerckhove E, Roosens L, Siozopoulou V, Verbrugghe W, Aerts J, Huyskens J, Raemen H, Jorens PG. Namn Y, Schneider Y, Cui IH, Jesudian A. Airway necrosis and barotrauma after ecstasy (MDMA) Diphenhydramine as a cause of drug-induced liver injury. inhalation.

Am J Respir Crit Care Med 2017; online early: Lentini P, Zanoli L, Granata A, Signorelli SS, Castellino P, doi: 10.1164/rccm.201612-2416IM: Dell'Aquila R. Kidney and heavy metals - The role of environmental Wong B, Perkins MW, Tressler J, Rodriguez A, Devorak J, exposure (review). Sciuto AM. Mol Med Rep 2017; online early: Effects of inhaled aerosolized carfentanil on real-time doi: 10.3892/mmr.2017.6389: physiological responses in mice: a preliminary evaluation of naloxone. Lenz B, Brink A, Siam M, De Paepe A, Bassett S, Eichinger- Inhal Toxicol 2017; 29: 65-74. Chapelon A, Maliver P, Neff R, Niederhauser U, Steinhuber B, Zurbach R, Singer T, Funk C, Schuler F, Albassam M, Kinetics Schadt S. Fraissinet F, Lesourd M, Naudoux N, Metsu D, Gandia P. Application of imaging techniques to cases of drug- induced crystal nephropathy in preclinical studies. Pharmacokinetics of teicoplanin in a breastfeeding mother. Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx044: Breastfeed Med 2017; online early: doi: 10.1089/bfm.2017.0016: Mendonca S, Gupta D, Valsan A, Tewari R. Høiseth G, Gottås A, Berg T, Arnestad M, Halvorsen PS, Warfarin related acute kidney injury: a case report. Bachs LC. Indian J Nephrol 2017; 27: 78-80. Urinary kinetics of heroin metabolites in pigs shortly after intake. Nincevic Z, Lasic D, Glavina T, Mikacic M, Carev M, Podrug K. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx017: Quetiapine poisoning associated with neuroleptic malignant syndrome, rhabdomyolysis and renal failure: a case report. Mavrakanas TA, Samer CF, Nessim SJ, Frisch G, Lipman ML. Psychiatr Danub 2017; 29: 84-6. Apixaban pharmacokinetics at steady state in hemodialysis patients. Neurotoxicity J Am Soc Nephrol 2017; online early: Bezdicek O, Michalec J, Vaneckova M, Klempir J, Liskova I, doi: 10.1681/ASN.2016090980: Seidl Z, Janikova B, Miovsky M, Hubacek J, Diblik P, Kuthan P, Pilin A, Kurcova I, Fenclova Z, Petrik V, Navratil Mechanisms of toxicity T, Pelclova D, Zakharov S, Ruzicka E. Nourani MR, Mahmoodzadeh Hosseini H, Azimzadeh Cognitive sequelae of methanol poisoning involve Jamalkandi S, Imani Fooladi AA. executive dysfunction and memory impairment in cross- Cellular and molecular mechanisms of acute exposure to sectional and long-term perspective. sulfur mustard: a systematic review. Alcohol 2017; 59: 27-35. J Recept Signal Transduct Res 2017; 37: 200-16. Bjørklund G, Chartrand MS, Aaseth J. Turillazzi E, Cerretani D, Cantatore S, Fiaschi AI, Frati P, Manganese exposure and neurotoxic effects in children. Micheli L, Neri M, Cipolloni L, Di Paolo M, Pinchi E, Riezzo Environ Res 2017; 155: 380-4. I, Santurro A, Vullo A, Fineschi V. Myocardial oxidative damage is induced by cardiac Fas- Cervello S, Cancel A, Boutet C, Schneider F, Giraux P, dependent and mitochondria-dependent apoptotic Laurent B, Fakra E. pathways in human cocaine-related overdose. Atypical permanent neurological sequelae after an acute Sci Rep 2017; 7: 44262. intoxication with lithium and aripiprazole. J Affect Disord 2017; 214: 97-9. Medication errors Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Kramers C, Janssen BJ, Knol W, Hessel MHM, Mulder WM, Garbow JR, Lein PJ. Dumont G, van den Brink AM, Tichelaar J. Magnetic resonance imaging reveals progressive brain injury A licence to prescribe. in rats acutely intoxicated with diisopropylfluorophosphate. Br J Clin Pharmacol 2017; online early: Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx049: doi: 10.1111/bcp.13257:

Lloyd SA, Corkill B, Bruster MC, Roberts RL, Shanks RA. Metabolism Chronic methamphetamine exposure significantly Van Vleet TR, Liu H, Lee A, Blomme EA. decreases microglia activation in the arcuate nucleus. Acyl glucuronide metabolites: implications for drug safety J Chem Neuroanat 2017; 82: 5-11. assessment. Toxicol Lett 2017; 272: 1-7. Nincevic Z, Lasic D, Glavina T, Mikacic M, Carev M, Podrug K. Quetiapine poisoning associated with neuroleptic malignant Nephrotoxicity syndrome, rhabdomyolysis and renal failure: a case report. Aye K-P, Thanachartwet V, Soe C, Desakorn V, Thwin K-T, Psychiatr Danub 2017; 29: 84-6. Chamnanchanunt S, Sahassananda D, Supaporn T, Sitprija V. Clinical and laboratory parameters associated with acute Ravikanth R. kidney injury in patients with snakebite envenomation: a Role of magnetic resonance imaging in diagnosing prospective observational study from Myanmar. neurological complications in intermediate syndrome of BMC Nephrol 2017; 18: 92. organophosphate poisoning. Indian J Crit Care Med 2017; 21: 105-7. Dogan I, Eser B, Seker A. Rare cause of acute kidney injury associated with Ruszkiewicz JA, Li S, Rodriguez MB, Aschner M. rhabdomyolysis: quail meat consumption. Is triclosan a neurotoxic agent? Ther Apher Dial 2016; 20: 690-1. J Toxicol Environ Health B Crit Rev 2017; 20: 104-17.

Shin E-J, Dang D-K, Tran T-V, Tran H-Q, Jeong JH, Nah S- Genetic variability in the system of natriuretic B peptide Y, Jang C-G, Yamada K, Nabeshima T, Kim H-C. and principal toxicological parameters in workers exposed Current understanding of methamphetamine-associated to lead. dopaminergic neurodegeneration and psychotoxic be- Environ Toxicol Pharmacol 2017; 49: 74-80. haviors. Arch Pharm Res 2017; online early: doi: 10.1007/s12272- Jurek T, Rorat M. 017-0897-y: Fatal accidents at work in agriculture associated with alcohol intoxication in Lower Silesia in Poland. Wilks AB, Saif MW. Med Pr 2017; 68: 23-30. First case of foot drop associated with capecitabine in a patient with thymidylate synthase polymorphism. Lerro CC, Beane Freeman LE, Portengen L, Kang D, Lee K, Cureus 2017; 9: e995. Blair A, Lynch CF, Bakke B, De Roos AJ, Vermeulen RCH. A longitudinal study of atrazine and 2,4-D exposure and Occupational toxicology oxidative stress markers among iowa corn farmers. Environ Mol Mutagen 2017; 58: 30-8. Arcury TA, Laurienti PJ, Chen H, Howard TD, Barr DB,

Mora DC, Summers P, Quandt SA. Mortimer K, Feary J. Organophosphate pesticide urinary metabolites among Occupational exposure to pesticides: time to nip it in the latino immigrants: North Carolina farmworkers and non- bud? farmworkers compared. Thorax 2017; online early: doi: 10.1136/thoraxjnl-2016- J Occup Environ Med 2016; 58: 1079-86. 209686:

Barlow CA, Sahmel J, Paustenbach DJ, Henshaw JL. Möhner M, Wendt A. History of knowledge and evolution of occupational health A critical review of the relationship between occupational and regulatory aspects of asbestos exposure science: exposure to diesel emissions and lung cancer risk. 1900–1975. Crit Rev Toxicol 2017; 47: 185-224. Crit Rev Toxicol 2017; online early: doi: 10.1080/10408444.2016.1258391: Muñoz-Quezada MT, Lucero B, Iglesias V, Levy K, Muñoz MP, Achú E, Cornejo C, Concha C, Brito AM, Villalobos M. Boffetta P, Fordyce TA, Mandel JS. Exposure to organophosphate (OP) pesticides and health A mortality study of beryllium workers. conditions in agricultural and non-agricultural workers Cancer Med 2016; 5: 3596-605. from Maule, Chile. Int J Environ Health Res 2017; 27: 82-93. Colomb S, Bourrain JL, Bonardel N, Chiriac A, Demoly P. Occupational opiate contact dermatitis. Nair AJ, Nandini M, Adappa S, Mahabala C. Contact Derm 2017; 76: 240-1. Carbon monoxide exposure among police officers working in a traffic dense region of Southern India. Costa C, Miozzi E, Teodoro M, Briguglio G, Rapisarda V, Toxicol Ind Health 2017; 33: 46-52. Fenga C. New insights on 'old' toxicants in occupational toxicology Podlewski R, Plotek W, Grzeskowiak M, Malkiewicz T, (review). Frydrysiak K, Zaba Z. Mol Med Rep 2017; online early: Carbon dioxide as a potential danger to medical rescue doi: 10.3892/mmr.2017.6374: teams at work - a case study. Med Pr 2017; 68: 135-8. Dutta S, Bahadur M. Cytogenetic analysis of micronuclei and cell death Rusiecki JA, Beane Freeman LE, Bonner MR, Alexander M, parameters in epithelial cells of pesticide exposed tea Chen L, Andreotti G, Barry KH, Moore LE, Byun H-M, garden workers. Kamel F, Alavanja M, Hoppin JA, Baccarelli A. Toxicol Mech Methods 2016; 26: 627-34. High pesticide exposure events and DNA methylation among pesticide applicators in the agricultural health study. Fenga C, Gangemi S, Di Salvatore V, Falzone L, Libra M. Environ Mol Mutagen 2017; 58: 19-29. Immunological effects of occupational exposure to lead (review). Ryu J, Lim KH, Ryu D-R, Lee HW, Yun JY, Kim S-W, Kim J- Mol Med Rep 2017; online early: H, Jung-Choi K, Kim H. doi: 10.3892/mmr.2017.6381: Two cases of methyl alcohol intoxication by sub-chronic inhalation and dermal exposure during aluminum CNC Haraux E, Braun K, Buisson P, Stéphan-Blanchard E, cutting in a small-sized subcontracted factory. Devauchelle C, Ricard J, Boudailliez B, Tourneux P, Ann Occup Environ Med 2016; 28: 65. Gouron R, Chardon K. Maternal exposure to domestic hair cosmetics and Smiechowicz J, Skoczynska A, Nieckula-Szwarc A, Kulpa K, occupational endocrine disruptors is associated with a Kübler A. higher risk of hypospadias in the offspring. Occupational mercury vapour poisoning with a respiratory Int J Environ Res Public Health 2017; 14: 27. failure, pneumomediastinum and severe quadriparesis. SAGE Open Med Case Rep 2017; 5: Holland MG, Cawthon D, Dreger M. doi: 10.1177/2050313X17695472. Workplace lead exposure. J Occup Environ Med 2016; 58: e371-e374. Ocular toxicity Espandar G, Moghimi J, Ghorbani R, Pourazizi M, Seiri M- Jurdziak M, Gac P, Poreba R, Gonerska M, Jonkisz A, A, Khosravi S. Gromek M, Poreba M, Szymanska-Chabowska A, Mazur G, Retinal toxicity in patients treated with hydroxychloroquine: Sobieszczanska M. a cross-sectional study.

Med Hypothesis Discov Innov Ophthalmol 2016; 5: 41-6. Outpatient management of neonatal abstinence syndrome: a quality improvement project. Jian-Wei L, Xiu-Yun L, Ai-Jun D. Jt Comm J Qual Patient Saf 2016; 42: 506-15. Effectiveness of heparin eye drops in paraquat-induced ocular injury. Dai Y, Huo X, Zhang Y, Yang T, Li M, Xu X. Cutan Ocul Toxicol 2017; online early: Elevated lead levels and changes in blood morphology and doi: 10.1080/15569527.2017.1303706: erythrocyte CR1 in preschool children from an e-waste area. Luis J, Virdi M, Nabili S. Sci Total Environ 2017; 592: 51-9. Poppers retinopathy. BMJ Case Rep 2016; doi: 10.1136/bcr-2016-214442: Das Adhikari D, Das S, Winston AB, Vazhudhi K, Kumar A, Shanthi M, Agarwal I. Shoeibi N, Mousavi MN, Balali-Mood M, Moshiri M, Darchini- A retrospective study on non-drug related poisoning in the Maragheh E, Mousavi SR, Abrishami M. community among children from south India. Long-term complications of sulfur mustard poisoning: Hosp Pract (1995) 2017; online early: retinal electrophysiological assessment in 40 severely doi: 10.1080/21548331.2017.1303326: intoxicated Iranian veterans. Int J Retina Vitreous 2017; 3: 7. Ercan ES, Inci SB, Ipci M. Is there an effect of methylphenidate on thrombocytopenia? Paediatric toxicology J Clin Psychopharmacol 2017; online early: Abraham K. doi: 10.1097/JCP.0000000000000690: Risks of dioxins resulting from high exposure via breastfeeding? Gaither JR, Leventhal JM, Ryan SA, Camenga DR. Arch Toxicol 2017; online early: doi: 10.1007/s00204-017- National trends in hospitalizations for opioid poisonings 1952-7: among children and adolescents, 1997 to 2012. JAMA Pediatr 2016; 170: 1195-201. Adedokun C, O'Sullivan I, Murphy A, Muhammed R. Methotrexate acute accidental ingestion. Gee SW, Outsen S, Becknell B, Schwaderer AL. Eur J Pediatr 2016; 175: 1532. Baclofen toxicity responsive to hemodialysis in a pediatric patient with acute kidney injury. Allen JD, Casavant MJ, Spiller HA, Chounthirath T, Hodges J Pediatr Intensive Care 2016; 5: 37-40. NL, Smith GA. Prescription opioid exposures among children and Grama A, Bizo A, Delean D, Aldea C, Pop TL. adolescents in the United States: 2000–2015. Drug-induced acute liver failure in children. Pediatrics 2017; online early: doi: 10.1542/peds.2016- Eur J Pediatr 2016; 175: 1738. 3382: Grama A, Bizo A, Delean D, Aldea C, Stefanescu A, Pop TL. Bakalli I, Celaj E, Kola E, Sala D, Lluka R, Gjeta I, Treatment of acute liver failure caused by mushroom Sallabanda S. poisoning in children. Pattern of acute poisoning among children in Albania. Eur J Pediatr 2016; 175: 1738. Eur J Pediatr 2016; 175: 1561-2. Harris MH, Rifas-Shiman SL, Calafat AM, Ye X, Mora AM, Bjørklund G, Chartrand MS, Aaseth J. Webster TF, Oken E, Sagiv SK. Manganese exposure and neurotoxic effects in children. Predictors of per- and polyfluoroalkyl substance (PFAS) Environ Res 2017; 155: 380-4. plasma concentrations in 6-10 year old American children. Environ Sci Technol 2017; online early: Bjune T, Risgaard B, Kruckow L, Glinge C, Ingemann- doi: 10.1021/acs.est.6b05811: Hansen O, Leth PM, Linnet K, Banner J, Winkel BG, Tfelt- Hansen J. Hassanian-Moghaddam H, Hakiminejhad M, Farnaghi F, Post-mortem toxicology in young sudden cardiac death Mirafzal A, Zamani N, Kabir A. victims: a nationwide cohort study. Eleven years of children methadone poisoning in a referral Europace 2017; online early: center: a review of 453 cases. doi: 10.1093/europace/euw435: J Opioid Manag 2017; 13: 27-36.

Bouziri A, Loueti A, Ayari A, Narjess G, Khaldi A, Menif K, Kumar K, Kumar R, Kumar K. Borgi A, Ben Jaballah N. Magnesium intoxication: an unusual differential for an Acute severe poisoning in a pediatric intensive care unit: unresponsive child. the experience of a single-center over a period of 14 Eur J Pediatr 2016; 175: 1678. years. Eur J Pediatr 2016; 175: 1461-2. LaRochelle JM, Desselle B, Rossi JL. Continuous-infusion etomidate in a patient receiving Cardenas A, Rifas-Shiman SL, Agha G, Hivert M-F, Litonjua extracorporeal membrane oxygenation. AA, DeMeo DL, Lin X, Amarasiriwardena CJ, Oken E, J Pediatr Pharmacol Ther 2017; 22: 65-8. Gillman MW, Baccarelli AA. Persistent DNA methylation changes associated with prenatal López-Rodríguez G, Galván M, González-Unzaga M, mercury exposure and cognitive performance during Hernández Ávila J, Pérez-Labra M. childhood. Blood toxic metals and hemoglobin levels in Mexican Sci Rep 2017; 7: 288. children. Environ Monit Assess 2017; 189: 179. Chau KT, Nguyen J, Miladinovic B, Lilly CM, Ashmeade TL, Balakrishnan M. Mactier H.

Commentary on Gibson et al. (2017): Gestational age and The first use of pralidoxime in a child with rivastigmine the severity of neonatal abstinence syndrome. poisoning. Addiction 2017; 112: 717-8. Pediatr Emerg Care 2017; online early: doi: 10.1097/PEC.0000000000001086: Mataftsi A, Malamaki P, Prousali E, Riga P, Lathyris D, Chalvatzis NT, Haidich A-B. Schwartz L, Mercurio-Zappala M, Howland MA, Hoffman Safety and efficacy of chloral hydrate for procedural RS, Su MK. sedation in paediatric ophthalmology: a systematic review Unintentional methadone and buprenorphine exposures in and meta-analysis. children: developing prevention messages. Br J Ophthalmol 2017; online early: J Am Pharm Assoc (Wash ) 2017; 57: S83-S86. doi: 10.1136/bjophthalmol-2016-309449: Seo AD, Kim DC, Yu HJ, Kang MJ. Montague AJ, Bangh S, Cole JB. Accidental ingestion of E-cigarette liquid nicotine in a 15- Bradycardia in a child after using brimonidine as toothpaste. month-old child: an infant mortality case of nicotine JAMA Dermatol 2017; online early: intoxication. doi: 10.1001/jamadermatol.2016.6215: Korean J Pediatr 2016; 59: 490-3.

Nocera M. Shao W, Liu Q, He X, Liu H, Gu A, Jiang Z. A teenage girl with altered mental status and sinus tachy- Association between level of urinary trace heavy metals cardia. and obesity among children aged 6-19 years: NHANES Clin Pediatr Emerg Med 2016; 17: 312-6. 1999–2011. Environ Sci Pollut Res Int 2017; online early: Nouhjah S, Kalhori SRN, Saki A. doi: 10.1007/s11356-017-8803-1: Risk factors of non-fatal unintentional home injuries among children under 5 years old; a population-based Tassiopoulos K, Huo Y, Braun J, Williams PL, Smith R, study. Aschengrau A, Nichols S, Hazra R, Meyer WA, Knapp K, Emergency 2017; 5: e6. Deygoo NS, Seage GR, III.

Blood lead levels and neurodevelopmental function in Oulhote Y, Steuerwald U, Debes F, Weihe P, Grandjean P. perinatally HIV-exposed, uninfected children in a US-based Behavioral difficulties in 7-year old children in relation to longitudinal cohort study. developmental exposure to perfluorinated alkyl substances. AIDS Res Hum Retroviruses 2017; online early: Environ Int 2016; 97: 237-45. doi: 10.1089/AID.2016.0265:

Patel P, Zulf M, Yagnik B, Kajale N, Mandlik R, Khadilkar V, Vaz S, Jalles F, Santo RE, Boto L, Rios J, Camilo C, Chiplonkar S, Phanse S, Patwardhan V, Joshi P, Patel A, Abecasis F, Vieira M. Khadilkar A. Association of dental and skeletal fluorosis with calcium "Ketoacidosis, not always diabetic..". intake and serum Vitamin D concentration in adolescents Cogent Med 2016; 3: 66-7. from a region endemic for fluorosis. Indian J Endocrinol Metab 2017; 21: 190-5. Veneziano G, Tobias JD. Chloroprocaine for epidural anesthesia in infants and Pigatto PD, Ronchi A, Pallotti F, Guzzi G. children. Sudden death and toxic metals following ingestion of a Paediatr Anaesth 2017; online early: button battery. doi: 10.1111/pan.13134: Int J Legal Med 2017; online early: doi: 10.1007/s00414- 017-1572-z: Poisons information and poison information centres Prpic I, Milardovic A, Vlasic-Cicvaric I, Spiric Z, Radic Nisevic J, Vukelic P, Snoj Tratnik J, Mazej D, Horvat M. Chan YC, Tse ML, Lau FL. Prenatal exposure to low-level methylmercury alters the Hong Kong Poison Information Centre: annual report child's fine motor skills at the age of 18 months. 2015. Environ Res 2017; 152: 369-74. Hong Kong J Emerg Med 2016; 23: 358-70.

Ranathunga N, Perera P, Nandasena S, Sathiakumar N, Khalifa A, Del Fiol G, Cummins MR. Kasthuriratne A, Wikremasinghe R. Public health data for individual patient care: mapping Effects of indoor air pollution from solid fuel combustion Poison Control Center data to the C-CDA consultation on development of children under 5 years. note. Cogent Med 2016; 3: 52-3. AIMA Annu Symp Proc 2016; 2016: 1850-9.

Salmerón-Fernández MJ, Urrutia-Maldonado E, Abril- Weiss D, Tomasallo CD, Meiman JG, Creswell PD, Melstrom Molina A, Martín-García JA, Ales-Palmer ML, Gomez-Luque PC, Gummin DD, Patel DJ, Michaud NT, Sebero HA, JM, Martin-Massot R, Osorio-Camara JM, Ocete-Hita E. Anderson HA. Ibuprofen-induced hepatotoxicity in paediatric population. Electronic cigarette exposure: calls to Wisconsin poison Eur J Pediatr 2016; 175: 1620. control centers, 2010–2015. Wis Med J 2016; 115: 306-10. Santos C, Kieszak S, Wang A, Law R, Schier J, Wolkin A. Reported adverse health effects in children from ingestion Zuluaga AF, Rodriguez CA, Lastra-Bello S, Peña-Acevedo of alcohol-based hand sanitizers - United States, 2011- LM, Montoya-Giraldo MA. 2014. CIEMTO: the new drug and poison research and MMWR Morb Mortal Wkly Rep 2017; 66: 223-6. information center in Medellín, Colombia. Clin Toxicol 2017; online early: Saz EU, Yurtseven A, Kilinç MA, Sari Y, Agin H. doi: 10.1080/15563650.2017.1312003:

Polymorphisms Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Jr., Buschmann J, Calow P, Dagli ML, Date M, Dekant Matsusue A, Ishikawa T, Michiue T, Waters B, Hara K, W, Deodhar C, Fryer AD, Joshi K, La Cava S, Lapczynski A, Kashiwagi M, Takayama M, Ikematsu N, Kubo S-I. Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, Association between cerebrospinal fluid dopamine Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, concentrations and catechol-O-methyltransferase gene Thakkar Y, Tsang S, Wahler J. polymorphisms in forensic autopsy cases of metham- RIFM fragrance ingredient safety assessment, isoamyl phetamine abusers. propionate, CAS registry number 105-68-0. Forensic Sci Int 2017; 270: 159-64. Food Chem Toxicol 2017; online early: doi: 10.1016/j.fct.2017.03.021:

Psychiatric aspects Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton Bassirnia A, Medrano B, Monte A, Calelo D, Manini AF, GA, Jr., Buschmann J, Calow P, Dagli ML, Date M, Dekant Perkel C, Galynker I, Hurd Y. W, Deodhar C, Fryer AD, Joshi K, La Cava S, Lapczynski A, Synthetic cannabinoids (SC) association with psychosis Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, and agitation. Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Neuropsychopharmacology 2016; 41: S274-S275. Thakkar Y, Tsang S, Wahler J. RIFM fragrance ingredient safety assessment, isoamyl

octanoate, CAS registry number 2035-99-6. Reprotoxicity Food Chem Toxicol 2017; online early: Borges CS, Pacheco TL, Guerra MT, Barros AL, Silva PV, doi: 10.1016/j.fct.2017.02.036: Missassi G, da Silva KP, Anselmo-Franci JA, Pupo AS, Kempinas WdG. Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Jr., Reproductive disorders in female rats after prenatal Buschmann J, Calow P, Dagli ML, Dekant W, Fryer AD, La exposure to betamethasone. Cava S, Lapczynski A, Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Romine J, Salvito D, Schultz J Appl Toxicol 2017; online early: doi: 10.1002/jat.3457: TW, Shen J, Sipes IG, Wahler J. RIFM Fragrance ingredient safety assessment, 6-acetyl- Grosen A, Kelsen J, Hvas CL, Bellaguarda E, Hanauer SB. 1,1,2,4,4,7-hexamethyltetraline, CAS registry number The influence of methotrexate treatment on male fertility 21145-77-7. and pregnancy outcome after paternal exposure. Food Chem Toxicol 2017; online early: Inflamm Bowel Dis 2017; 23: 561-9. doi: 10.1016/j.fct.2017.03.019:

Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton Remy LL, Byers V, Clay T. GA, Jr., Buschmann J, Calow P, Dagli ML, Date M, Dekant Reproductive outcomes after non-occupational exposure W, Deodhar C, Fryer AD, Joshi K, La Cava S, Lapczynski A, to hexavalent chromium, Willits California, 1983–2014. Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, Environ Health 2017; 16: 18. Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Tsang S, Wahler J. RIFM fragrance ingredient safety assessment, l- Risk assessment cyclocitronellene formate, CAS registry number 25225-08-5. Alves JC, de Paiva EL, Milani RF, Bearzoti E, Morgano MA, Food Chem Toxicol 2017; online early: Diego Quintaes K. doi: 10.1016/j.fct.2017.02.035: Risk estimation to human health caused by the mercury content of Sushi and Sashimi sold in Japanese restaurants Api AM, Belsito D, Bhatia S, Botelho D, Browne D, Bruze M, in Brazil. Burton GA, Jr., Buschmann J, Calow P, Dagli ML, Date M, J Environ Sci Health [B] 2017; online early: Dekant W, Deodhar C, Fryer AD, Kromidas L, La Cava S, doi: 10.1080/03601234.2017.1293451: Lalko J, Lapczynski A, Liebler DC, Miyachi Y, O'Brien D, Parakhia R, Patel A, Penning TM, Politano VT, Ritacco G,

Romine J, Salvito D, Schultz TW, Shen J. Api AM, Belsito D, Bhatia S, Botelho D, Brown D, Bruze M, RIFM fragrance ingredient safety assessment, d- Burton GA, Jr., Buschmann J, Calow P, Dagli ML, Date M, cyclocitronellene acetate, CAS registry number 25225-10-9. Dekant W, Fryer AD, Kromidas L, Lalko J, La Cava S, Food Chem Toxicol 2017; online early: Lapczynski A, Liebler DC, O'Brien D, Parakhia R, Patel A, doi: 10.1016/j.fct.2017.03.004: Penning TM, Politano VT, Ritacco G, Romine J, Salvito D, Schultz TW, Shen J, Sipes IG, Thakkar Y. Brunt TM, van den Berg J, Pennings E, Venhuis B. RIFM fragrance ingredient safety assessment, isolongifolene Adverse effects of levamisole in cocaine users: a review ketone, CAS registry number 23787-90-8. and risk assessment. Food Chem Toxicol 2017; online early: Arch Toxicol 2017; online early: doi: 10.1007/s00204-017- doi: 10.1016/j.fct.2017.02.034: 1947-4:

Chen C-C, Wang S-L, Wu M-T, Wang Y-H, Huang P-C, Chen Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton B-H, Sun C-W, Ho C-K, Shih Y-C, Shiu M-N, Pan W-H, Chen GA, Jr., Buschmann J, Calow P, Dagli ML, Date M, Dekant M-L, Lee C-C, Hsiung C-A. W, Deodhar C, Fryer AD, Joshi K, La Cava S, Lapczynski A, Exposure estimation for risk assessment of the phthalate Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, incident in Taiwan. Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, PLoS ONE 2016; 11: e0151070. Thakkar Y, Tsang S, Wahler J.

RIFM fragrance ingredient safety assessment, isotridecyl Guissouma W, Hakami O, Al-Rajab AJ, Tarhouni J. acetate, CAS registry number 69103-23-7. Risk assessment of fluoride exposure in drinking water of Food Chem Toxicol 2017; online early: Tunisia. doi: 10.1016/j.fct.2017.03.003: Chemosphere 2017; 177: 102-8.

Hernández AF, Tsatsakis AM. Yip PSF, Cheng Q, Chang S-S, Lee EST, Lai C-SC, Chen F, Human exposure to chemical mixtures: Challenges for the Law Y-WF, Cheng TME, Chiu SM, Tse YLJ, Cheung K-WR, integration of toxicology with epidemiology data in risk Tse M-L, Morgan PR, Beh P. assessment. A public health approach in responding to the spread of Food Chem Toxicol 2017; 103: 188-93. helium suicide in Hong Kong. Crisis 2017; online early: doi: 10.1027/0227-5910/a000449: Linke B, Mohr S, Ramsingh D, Bhuller Y. A retrospective analysis of the added value of 1-year dog MANAGEMENT studies in pesticide human health risk assessments. Crit Rev Toxicol 2017; online early: General doi: 10.1080/10408444.2017.1290044: Azarov I, Wang L, Rose JJ, Xu Q, Huang XN, Belanger A, Wang Y, Guo L, Liu C, Ucer KB, McTiernan CF, O'Donnell Satarug S, Vesey DA, Gobe GC. CP, Shiva S, Tejero J, Kim-Shapiro DB, Gladwin MT. Health risk assessment of dietary cadmium intake: do Five-coordinate H64Q neuroglobin as a ligand-trap current guidelines indicate how much is safe? antidote for carbon monoxide poisoning. Environ Health Perspect 2017; 125: 284-8. Sci Transl Med 2016; 8: 368ra173.

Xiang P, Liu R-Y, Sun H-J, Yang Y-W, Cui X-Y, Ma LQ. Bao H-X, Tong P-J, Li C-X, Du J, Chen B-Y, Huang Z-H, Effects of novel brominated flame retardant TBPH and its Wang Y. metabolite TBMEHP on human vascular endothelial cells: Efficacy of fresh packed red blood transfusion in Implication for human health risks. organophosphate poisoning. Environ Res 2017; online early: Medicine (Baltimore) 2017; 96: e6375. doi: 10.1016/j.envres.2017.02.028: Bateman DN, Dear JW. Should we treat very large paracetamol overdose Suicide differently? Dodds TJ. Br J Clin Pharmacol 2017; online early: Prescribed benzodiazepines and suicide risk: a review of doi: 10.1111/bcp.13279: the literature. Prim Care Companion CNS Disord 2017; 19: 16r02037. Carmany D, Walz AJ, Hsu F-L, Benton B, Burnett D, Gibbons J, Noort D, Glaros T, Sekowski JW. Knipe DW, Chang S-S, Dawson A, Eddleston M, Konradsen Activity based protein profiling leads to identification of F, Metcalfe C, Gunnell D. novel protein targets for nerve agent VX. Suicide prevention through means restriction: Impact of Chem Res Toxicol 2017; online early: the 2008-2011 pesticide restrictions on suicide in Sri doi: 10.1021/acs.chemrestox.6b00438: Lanka. PLoS ONE 2017; 12: e0172893. Dijkstra BAG, Kamal R, van Noorden MS, de Haan H, Loonen AJM, De Jong CAJ. Masters RK, Tilstra AM, Simon DH. Detoxification with titration and tapering in gamma- Mortality from suicide, chronic liver disease, and drug hydroxybutyrate (GHB) dependent patients: the Dutch poisonings among middle-aged U.S. white men and women, GHB monitor project. 1980–2013. Drug Alcohol Depend 2017; 170: 164-73. Biodemography Soc Biol 2017; 63: 31-7. Grama A, Bizo A, Delean D, Aldea C, Stefanescu A, Pop TL. Noda AH, Schu U, Maier T, Knake S, Rosenow F. Treatment of acute liver failure caused by mushroom Epileptic seizures, coma and EEG burst-suppression from poisoning in children. suicidal bupropion intoxication. Eur J Pediatr 2016; 175: 1738. Epileptic Disord 2017; online early: doi: 10.1684/epd.2017.0896: Isoardi KZ, Armitage MC, Harris K, Page CB. Establishing a dedicated toxicology unit reduces length of Olfson M, Wall M, Wang S, Crystal S, Gerhard T, Blanco C. stay of poisoned patients and saves hospital bed days. Suicide following deliberate self-harm. Emerg Med Australas 2017; online early: Am J Psychiatry 2017; online early: doi: 10.1111/1742-6723.12755: doi: 10.1176/appi.ajp.2017.16111288: Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Schaffer A, Weinstock LM, Sinyor M, Reis C, Goldstein BI, Gladwin MT. Yatham LN, Levitt AJ. Reply: Better studies are needed to guide treatment of Self-poisoning suicide deaths in people with bipolar carbon monoxide poisoning. disorder: characterizing a subgroup and identifying Am J Respir Crit Care Med 2017; 195: 694-5. treatment patterns. Int J Bipolar Disord 2017; 5: 16. Rulisek J, Balik M, Polak F, Waldauf P, Pelclova D, Belohlavek J, Zakharov S. Shokrzadeh M, Hoseinpoor R, Hajimohammadi A, Delaram Cost-effectiveness of hospital treatment and outcomes of A, Shayeste Y. acute methanol poisoning during the Czech Republic mass Epidemiological survey of suicide attempt by drug poisoning outbreak. poisoning in Gorgan, Iran, 2008 to 2015. J Crit Care 2017; online early: J Mazandaran Univ Med Sci 2016; 26: 201-10. doi: 10.1016/j.jcrc.2017.03.001:

Subhedar A, Karunaker B, Surendar J. Srivastava A, Kahan M, Nader M. Comprehensive study of suicidal deaths due to insecticidal Primary care management of opioid use disorders: poisons in females. abstinence, methadone, or buprenorphine-naloxone? Indian J Forensic Med Toxicol 2017; 11: 10-2. Can Fam Physician 2017; 63: 200-5.

Winstanley EL, Mashni R, Schnee S, Miller N, Mashni SM. doi: 10.1080/15563650.2017.1300261: The development and feasibility of a pharmacy-delivered opioid intervention in the emergency department. Santos Barreto GNL, de Oliveira SS, Dos Anjos IV, J Am Pharm Assoc (Wash ) 2017; 57: S87-S91. Chalkidis HdM, Mourão RHV, da Silva AMM, Sano-Martins IS, Gonçalves LRdC. Wodarz N, Krampe-Scheidler A, Christ M, Fleischmann H, Experimental Bothrops atrox envenomation: efficacy of Looser W, Schoett K, Vilsmeier F, Bothe L, Schaefer C, antivenom therapy and the combination of Bothrops Gouzoulis-Mayfrank E. antivenom with dexamethasone. Evidence-based guidelines for the pharmacological man- PLoS Negl Trop Dis 2017; 11: e0005458. agement of acute methamphetamine-related disorders and toxicity. DMSA Pharmacopsychiatry 2017; online early: doi: 10.1055/s- Varma A, Bradberry SM, Vale JA. 0042-123752: Rash and pyrexia after succimer (dimercaptosuccinic acid; DMSA). Yan W. Clin Toxicol 2017; online early: Carbon monoxide, the silent killer, may have met its match. doi: 10.1080/15563650.2017.1304553: Science 2016; 354: 1215.

Hydroxocobalamin Antidotes Legrand M, Michel T. Fernandes LCR, Galvão TF, Ricardi AST, de Capitani EM, Empiric use of hydroxocobalamin in patients with smoke Hyslop S, Bucaretchi F. inhlation injury: not so fast! Antidote availability in the municipality of Campinas, São Burns 2016; online early: doi: 10.1016/j.burns.2016.11.017: Paulo, Brazil.

Sao Paulo Med J 2017; online early: doi: 10.1590/1516- 3180.2016.00171120816: Idarucizumab Gendron N, Feral-Pierssens AL, Jurcisin I, de Raucourt E, Bouton V, Fischer AM, Lorenceau-Savale C, Lillo-Le Louët Acetylcysteine A, Smadja DM. Schneider R, Jr., Bandiera S, Souza DG, Bellaver B, Caletti Real-world use of idarucizumab for dabigatran reversal in G, Quincozes-Santos A, Elisabetsky E, Gomez R. three cases of serious bleeding. N-acetylcysteine prevents alcohol related neuroinflammation Clin Case Rep 2017; 5: 346-50. in rats.

Neurochem Res 2017; online early: doi: 10.1007/s11064- 017-2218-8: Isosorbide dinitrate Lavon O, Avrahami A, Eisenkraft A. Activated charcoal Effectiveness of cyanide; treatment in cyanide poisoning as a function of the administration timing. Pfab R, Schmoll S, Dostal G, Stenzel J, Hapfelmeier A, BMC Pharmacol Toxicol 2017; 18: 13. Eyer F.

Single dose activated charcoal for gut decontamination: application by medical non-professionals - A prospective Lipid emulsion therapy study on availability and practicability. Ghadiri A, Etemad L, Moshiri M, Moallem SA, Jafarian AH, Toxicol Rep 2017; 4: 49-54. Hadizadeh F, Seifi M. Exploring the effect of intravenous lipid emulsion in acute Antivenom methamphetamine toxicity. Iran J Basic Med Sci 2017; 20: 138-44. Bailey AM, Justice S, Davis GA, Weant K.

Delayed hematologic toxicity following rattlesnake Weinberg G. envenomation unresponsive to crotalidae polyvalent Current evidence supports use of lipid rescue therapy in antivenom. local anaesthetic systemic toxicity. Am J Emerg Med 2017; online early: Acta Anaesthesiol Scand 2017; 61: 365-8. doi: 10.1016/j.ajem.2017.02.045:

Barbosa AN, Boyer L, Chippaux J-P, Medolago NB, Naloxone Caramori CA, Paixão AG, Poli JPV, Mendes MB, Dos Santos Black L, Connolly I, Getty M, Hogan C, Lennon P, Mc LD, Ferreira RS, Jr., Barraviera B. Cusker M, Neale J, Strang J, On behalf of the Addiction A clinical trial protocol to treat massive Africanized honey- Service User Research Group. bee (Apis mellifera) attack with a new apilic antivenom. Poor implementation of naloxone needs to be better J Venom Anim Toxins Incl Trop Dis 2017; 23: 14. understood in order to save lives. Addiction 2017; online early: doi: 10.1111/add.13778: de Roodt AR, Lanari LC, Laskowicz RD, De Oliveira VC, Irazu LE, González A, Giambelluca L, Nicolai N, Barragán JH, Chwistek M, Wolf M. Ramallo L, López RA, Lopardo J, Jensen O, Larrieu E, Naloxone for outpatients at risk of opioid overdose #328. Calabró A, Vurcharchuc MG, Lago NR, García SI, de Titto J Palliat Med 2017; online early: EH, Damín CF. doi: 10.1089/jpm.2017.0087: Toxicity of the venom of Latrodectus (Araneae: Theridiidae) spiders from different regions of Argentina and Duvivier H, Gustafson S, Greutman M, Jangchup T, neutralization by therapeutic antivenoms. Harden AK, Reinhard A, Warshany K. Toxicon 2017; 130: 63-72. Indian Health Service pharmacists engaged in opioid safety initiatives and expanding access to naloxone. Lamb T, de Haro L, Lonati D, Brvar M, Eddleston M. J Am Pharm Assoc (Wash ) 2017; 57: S135-S140. Antivenom for European Vipera species envenoming. Clin Toxicol 2017; online early: Heavey SC, Burstein G, Moore C, Homish GG.

Overdose education and naloxone distribution program J Pediatr Intensive Care 2016; 5: 37-40. attendees: who attends, what do they know, and how do they feel? Haemoperfusion J Public Health Manag Pract 2017; online early: doi: Zhao A, Chen A, Guan Q, Shi J. 10.1097/PHH.0000000000000538: Effect of hemoperfusion on acute injury induced by acute organic phosphorus pesticide poisoning. Jones JD, Campbell A, Metz VE, Comer SD. Int J Clin Exp Med 2016; 9: 23440-6. No evidence of compensatory drug use risk behavior among heroin users after receiving take-home naloxone. Addict Behav 2017; 71: 104-6. Peritoneal dialysis Bashardoust B, Farzaneh E, Habibzadeh A, Sadeghi MSS. Nielsen S, Peacock A, Lintzeris N, Bruno R, Larance B, Successful treatment of severe metabolic acidosis due to Degenhardt L. acute aluminum phosphide poisoning with peritoneal Knowledge of opioid overdose and attitudes to supply of dialysis: a report of 2 cases. take-home naloxone among people with chronic Iran J Kidney Dis 2017; 11: 165-7. noncancer pain prescribed opioids. Pain Med 2017; online early: doi: 10.1093/pm/pnx021: Heparin Jian-Wei L, Xiu-Yun L, Ai-Jun D. Oliva EM, Christopher ML, Wells D, Bounthavong M, Effectiveness of heparin eye drops in paraquat-induced Harvey M, Himstreet J, Emmendorfer T, Valentino M, ocular injury. Franchi M, Goodman F, Trafton JA. Cutan Ocul Toxicol 2017; online early: Opioid overdose education and naloxone distribution: doi: 10.1080/15569527.2017.1303706: development of the veterans health administration's national program. Opioid maintenance therapy J Am Pharm Assoc (Wash ) 2017; 57: S168-S179.e4. Abrahamsson T, Berge J, Öjehagen A, Håkansson A.

Benzodiazepine, z-drug and pregabalin prescriptions and Wong B, Perkins MW, Tressler J, Rodriguez A, Devorak J, mortality among patients in opioid maintenance treatment Sciuto AM. — A nation-wide register-based open cohort study. Effects of inhaled aerosolized carfentanil on real-time Drug Alcohol Depend 2017; 174: 58-64. physiological responses in mice: a preliminary evaluation of naloxone. Inhal Toxicol 2017; 29: 65-74. Oxybutynin Hong J, Lee J, Totouom-Tangho H, Dunn NR, Swift RG. Etomidate Methadone-induced hyperhidrosis treated with oxybutynin. J Addict Med 2017; online early: LaRochelle JM, Desselle B, Rossi JL. doi: 10.1097/ADM.0000000000000300: Continuous-infusion etomidate in a patient receiving extracorporeal membrane oxygenation. J Pediatr Pharmacol Ther 2017; 22: 65-8. DRUGS General Extracorporeal treatments Bombana HS, Gjerde H, dos Santos MF, Jamt REG, Bouchard J, Lavergne V, Roberts DM, Cormier M, Yonamine M, Rohlfs WJC, Muñoz DR, Leyton V. Morissette G, Ghannoum M. Prevalence of drugs in oral fluid from truck drivers in Availability and cost of extracorporeal treatments for Brazilian highways. poisonings and other emergency indications: a worldwide Forensic Sci Int 2017; 273: 140-3. survey. Nephrol Dial Transplant 2017; 32: 699-706. Brinkley-Rubinstein L, Cloud DH, Davis C, Zaller N, Delany- Brumsey A, Pope L, Martino S, Bouvier B, Rich J. Extracorporeal membrane oxygenation Addressing excess risk of overdose among recently LaRochelle JM, Desselle B, Rossi JL. incarcerated people in the USA: harm reduction Continuous-infusion etomidate in a patient receiving interventions in correctional settings. extracorporeal membrane oxygenation. Int J Prison Health 2017; 13: 25-31. J Pediatr Pharmacol Ther 2017; 22: 65-8. Bukten A, Stavseth MR, Skurtveit S, Tverdal A, Strang J, Clausen T. High risk of overdose death following release from prison: Gastrointestinal decontamination Variations in mortality during a 15-year observation Vodovar D, Mégarbane B. period. Do not forget gastrointestinal decontamination in the early Addiction 2017; online early: doi: 10.1111/add.13803: management of lithium poisoning. Basic Clin Pharmacol Toxicol 2017; online early: Byard RW, Kenneally M. doi: 10.1111/bcpt.12758: Body pushing, prescription drugs and hospital admission. Forensic Sci Med Pathol 2017; online early: Zamani N, Paeezi M, Hassanian-Moghaddam H. doi: 10.1007/s12024-017-9855-8: Response to: Do not forget gastrointestinal decontamination in the early management of lithium poisoning. Chau KT, Nguyen J, Miladinovic B, Lilly CM, Ashmeade TL, Basic Clin Pharmacol Toxicol 2017; online early: Balakrishnan M. doi: 10.1111/bcpt.12759: Outpatient management of neonatal abstinence syndrome: a quality improvement project. Haemodialysis Jt Comm J Qual Patient Saf 2016; 42: 506-15. Gee SW, Outsen S, Becknell B, Schwaderer AL. Baclofen toxicity responsive to hemodialysis in a pediatric Chen HI-H, deJong J. patient with acute kidney injury. Increased lung weights in drug-related fatalities.

J Forensic Sci 2017; online early: doi: 10.1111/1556- ACMT position statement: determining brain death in 4029.13452: adults after drug overdose. J Med Toxicol 2017; online early: doi: 10.1007/s13181- Grama A, Bizo A, Delean D, Aldea C, Pop TL. 017-0606-8: Drug-induced acute liver failure in children. Eur J Pediatr 2016; 175: 1738. Okumura Y, Sakata N, Takahashi K, Nishi D, Tachimori H. Epidemiology of overdose episodes from the period prior Gupte-Singh K, Li H, Swain JL, Cheng Y, Regev A. to hospitalization for drug poisoning until discharge in Assessment of a severity-based algorithm to detect signals Japan: an exploratory descriptive study using a nationwide of severe drug-induced liver injury using spontaneous claims database. reporting database. J Epidemiol 2017; online early: Pharmaceut Med 2017; 31: 41-51. doi: 10.1016/j.je.2016.08.010:

Hedegaard H, Warner M, Minino AM. Rausch C, Laflamme L, Bültmann U, Möller J. Drug overdose deaths in the United States, 1999-2015. Number of medications and adverse drug events by NCHS Data Brief 2017; 1-8. unintentional poisoning among older adults in consideration of inappropriate drug use: a Swedish population-based Ho JY. matched case-control study. The contribution of drug overdose to educational gradients Eur J Clin Pharmacol 2017; online early: in life expectancy in the United States, 1992–2011. doi: 10.1007/s00228-017-2220-8: Demography 2017; online early: doi: 10.1007/s13524- 017-0565-3: Sadler Simões S, Castañera Ajenjo A, Dias MJ. Dried blood spots combined to an UPLC-MS/MS method Hunt CM, Papay JI, Stanulovic V, Regev A. for the simultaneous determination of drugs of abuse in Drug rechallenge following drug-induced liver injury. forensic toxicology. Hepatology 2017; online early: doi: 10.1002/hep.29152: J Pharm Biomed Anal 2017; online early: doi: 10.1016/j.jpba.2017.02.046: Khan LM, Kamel FO, Alkreathy HM, Al-Harthi SE, Saadah OI, Osman A-M, Allibaih MA. Sanna T, Olof B, Tessa B, Michaela B, Duncan C, Nadia F, Benefits of medication antidote signals for the detection of Claire G, Mark P, Alberto S, Wim S, Stefan S, Wolfgang W. potential adverse drug reactions over contemporary European guidelines for workplace drug testing in urine. methods of pharmacovigilance in hospitalized children. Drug Test Anal 2017; online early: doi: 10.1002/dta.2178: Int J Pharmacol 2017; 13: 64-73. Van Vleet TR, Liu H, Lee A, Blomme EA. Kramers C, Janssen BJ, Knol W, Hessel MHM, Mulder WM, Acyl glucuronide metabolites: implications for drug safety Dumont G, van den Brink AM, Tichelaar J. assessment. A licence to prescribe. Toxicol Lett 2017; 272: 1-7. Br J Clin Pharmacol 2017; online early: doi: 10.1111/bcp.13257: Veiga-Gómez M, Nebot C, Franco CM, Miranda JM,

Vázquez B, Cepeda A. Kullak-Ublick GA, Andrade RJ, Merz M, End P, Benesic A, Identification and quantification of 12 pharmaceuticals in Gerbes AL, Aithal GP. water collected from milking parlors: food safety Drug-induced liver injury: recent advances in diagnosis implications. and risk assessment. J Dairy Sci 2017; online early: doi: 10.3168/jds.2016-12227: Gut 2017; online early: doi: 10.1136/gutjnl-2016-313369:

Yang L-X, Liu C-Y, Zhang L-L, Lai L-L, Fang M, Zhang C. Lenz B, Brink A, Siam M, De Paepe A, Bassett S, Eichinger- Clinical characteristics of patients with drug-induced liver Chapelon A, Maliver P, Neff R, Niederhauser U, Steinhuber injury. B, Zurbach R, Singer T, Funk C, Schuler F, Albassam M, Chin Med J (Engl ) 2017; 130: 160-4. Schadt S.

Application of imaging techniques to cases of drug- induced crystal nephropathy in preclinical studies. Acetaminophen (see paracetamol) Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx044: Alkyl nitrites Lionte C, Sorodoc V, Jaba E, Botezat A. Luis J, Virdi M, Nabili S. Development and validation of a risk-prediction nomogram Poppers retinopathy. for in-hospital mortality in adults poisoned with drugs and BMJ Case Rep 2016; doi: 10.1136/bcr-2016-214442: nonpharmaceutical agents: an observational study.

Medicine (Baltimore) 2017; 96: e6404. Pain S, Chavant F, Fauconneau B, Guenezan J, Marjanovic

N, Lardeur J-Y, Brunet B, Perault-Pochat M-C. Lisi DM. Dangerous intoxication after oral ingestion of poppers Drug-induced liver injury: an overview. (alkyl nitrites): two case reports. US Pharm 2016; 41: 30-4. Thérapie 2016; online early:

doi: 10.1016/j.therap.2016.09.005: Mactier H.

Commentary on Gibson et al. (2017): Gestational age and the severity of neonatal abstinence syndrome. Amfetamines and MDMA (ecstasy) Addiction 2017; 112: 717-8. Al-Tayyib A, Koester S, Langegger S, Raville L. Heroin and methamphetamine injection: an emerging Neavyn MJ, Stolbach A, Greer DM, Nelson LS, Smith SW, drug use pattern. Brent J, Tormoehlen LM, On behalf of the American Subst Use Misuse 2017; online early: College of Medical Toxicology. doi: 10.1080/10826084.2016.1271432:

Ghadiri A, Etemad L, Moshiri M, Moallem SA, Jafarian AH, Antiarrhythmic drugs Hadizadeh F, Seifi M. Flecainide Exploring the effect of intravenous lipid emulsion in acute Bajaj S, Tullu MS, Khan Z, Agrawal M. methamphetamine toxicity. When potion becomes poison! A case report of flecainide Iran J Basic Med Sci 2017; 20: 138-44. toxicity. J Postgrad Med 2017; online early: doi: 10.4103/0022- Lloyd SA, Corkill B, Bruster MC, Roberts RL, Shanks RA. 3859.201422: Chronic methamphetamine exposure significantly decreases microglia activation in the arcuate nucleus. Antibiotics J Chem Neuroanat 2017; 82: 5-11. Neuville M, El-Helali N, Magalhaes E, Radjou A, Smonig R, Soubirou J-F, Voiriot G, Le Monnier A, Ruckly S, Bouadma Matsusue A, Ishikawa T, Michiue T, Waters B, Hara K, L, Sonneville R, Timsit J-F, Mourvillier B. Kashiwagi M, Takayama M, Ikematsu N, Kubo S-I. Systematic overdosing of oxa- and cloxacillin in severe Association between cerebrospinal fluid dopamine infections treated in ICU: risk factors and side effects. concentrations and catechol-O-methyltransferase gene Ann Intensive Care 2017; 7: 34. polymorphisms in forensic autopsy cases of methamphetamine abusers. Teicoplanin Forensic Sci Int 2017; 270: 159-64. Fraissinet F, Lesourd M, Naudoux N, Metsu D, Gandia P.

Pharmacokinetics of teicoplanin in a breastfeeding mother. Reece AS, Norman A, Hulse GK. Breastfeed Med 2017; online early: Acceleration of cardiovascular-biological age by amphet- doi: 10.1089/bfm.2017.0016: amine exposure is a power function of chronological age. Heart Asia 2017; 9: 30-8. Anticoagulants Stolk LM, De Vries F, Ebbelaar C, de Boer A, Schalekamp Shin E-J, Dang D-K, Tran T-V, Tran H-Q, Jeong JH, Nah S- T, Souverein P, Ten Cate-Hoek A, Burden AM. Y, Jang C-G, Yamada K, Nabeshima T, Kim H-C. Risk of myocardial infarction in patients with atrial Current understanding of methamphetamine-associated fibrillation using vitamin K antagonists, aspirin or direct dopaminergic neurodegeneration and psychotoxic behaviors. acting oral anticoagulants. Arch Pharm Res 2017; online early: doi: 10.1007/s12272- Br J Clin Pharmacol 2017; online early: 017-0897-y: doi: 10.1111/bcp.13264:

Van den Kerckhove E, Roosens L, Siozopoulou V, Verbrugghe W, Aerts J, Huyskens J, Raemen H, Jorens PG. Apixaban Mavrakanas TA, Samer CF, Nessim SJ, Frisch G, Lipman ML. Airway necrosis and barotrauma after ecstasy (MDMA) Apixaban pharmacokinetics at steady state in hemodialysis inhalation. patients. Am J Respir Crit Care Med 2017; online early: J Am Soc Nephrol 2017; online early: doi: 10.1164/rccm.201612-2416IM: doi: 10.1681/ASN.2016090980:

Wodarz N, Krampe-Scheidler A, Christ M, Fleischmann H, Looser W, Schoett K, Vilsmeier F, Bothe L, Schaefer C, Dabigatran Gouzoulis-Mayfrank E. Gendron N, Feral-Pierssens AL, Jurcisin I, de Raucourt E, Bouton V, Fischer AM, Lorenceau-Savale C, Lillo-Le Louët Evidence-based guidelines for the pharmacological man- A, Smadja DM. agement of acute methamphetamine-related disorders and Real-world use of idarucizumab for dabigatran reversal in toxicity. three cases of serious bleeding. Pharmacopsychiatry 2017; online early: doi: 10.1055/s- Clin Case Rep 2017; 5: 346-50. 0042-123752:

Zavgorodniaia T, Soichot M, Malissin I, Voicu S, Garçon P, Warfarin Goury A, Kerdjana L, Deye N, Bourgogne E, Megarbane B. Mendonca S, Gupta D, Valsan A, Tewari R. Warfarin related acute kidney injury: a case report. Life-threatening 3,4-methylenedioxy-methamphetamine Indian J Nephrol 2017; 27: 78-80. (MDMA) poisoning: clinical features and prognostic value of MDMA and its major metabolite concentrations on admission. Anticonvulsants Ann Intensive Care 2017; 7: 137. Gabapentin Evoy KE, Morrison MD, Saklad SR. Anaesthetics Abuse and misuse of pregabalin and gabapentin. Weinberg G. Drugs 2017; 77: 403-26.

Current evidence supports use of lipid rescue therapy in Nahar L, Smith A, Patel R, Andrews R, Paterson S. local anaesthetic systemic toxicity. Validated method for the screening and quantification of Acta Anaesthesiol Scand 2017; 61: 365-8. baclofen, gabapentin and pregabalin in human post-

mortem whole blood using protein precipitation and liquid Chloroprocaine chromatography-tandem mass spectrometry. Veneziano G, Tobias JD. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx019: Chloroprocaine for epidural anesthesia in infants and children. Levetiracetam Paediatr Anaesth 2017; online early: Sarfaraz M, Syeda RH. doi: 10.1111/pan.13134: Levetiracetam and topiramate poisoning: two overdoses on those drugs with no lasting effects.

Drug Discov Ther 2017; online early: Int J Rheum Dis 2017; online early: doi: 10.1111/1756- doi: 10.5582/ddt.2016.01082: 185X.13004:

Oxcarbazepine Demir FT, Tezcan Y, Türkoglu Z, Basaran S. Yousra H, Pierrick L, Laurent L, Daniele D. A case of severe low-dose methotrexate-induced toxicity. Interaction between clozapine and oxcarbazepine: a case Haseki Tip Bulteni 2016; 54: 252-4. report. Ther Adv Psychopharmacol 2017; 7: 95-9. Grosen A, Kelsen J, Hvas CL, Bellaguarda E, Hanauer SB. The influence of methotrexate treatment on male fertility Pregabalin and pregnancy outcome after paternal exposure. Evoy KE, Morrison MD, Saklad SR. Inflamm Bowel Dis 2017; 23: 561-9. Abuse and misuse of pregabalin and gabapentin. Drugs 2017; 77: 403-26. Soysal S, Ilhan GA, Vural M, Yildizhan B. Severe methotrexate toxicity after treatment for ectopic Nahar L, Smith A, Patel R, Andrews R, Paterson S. pregnancy: a case report. Validated method for the screening and quantification of Turk J Obstet Gynecol 2016; 13: 221-3. baclofen, gabapentin and pregabalin in human postmortem whole blood using protein precipitation and liquid Sparks JA, Barbhaiya M, Karlson EW, Ritter SY, chromatography-tandem mass spectrometry. Raychaudhuri S, Corrigan CC, Lu F, Selhub J, Chasman DI, J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx019: Paynter NP, Ridker PM, Solomon DH.

Investigating methotrexate toxicity within a randomized Topiramate double-blinded, placebo-controlled trial: rationale and Sarfaraz M, Syeda RH. design of the cardiovascular inflammation reduction trial- Levetiracetam and topiramate poisoning: two overdoses adverse events (CIRT-AE) study. on those drugs with no lasting effects. Semin Arthritis Rheum 2017; online early: Drug Discov Ther 2017; online early: doi: 10.1016/j.semarthrit.2017.02.003: doi: 10.5582/ddt.2016.01082:

Antipsychotics Antidepressants Gracia MS, Köppl A, Unholzer S, Haen E. Bupropion Development and validation of a HPLC-UV method for the Noda AH, Schu U, Maier T, Knake S, Rosenow F. simultaneous determination of the antipsychotics Epileptic seizures, coma and EEG burst-suppression from clozapine, olanzapine and quetiapine, several beta- suicidal bupropion intoxication. blockers and their metabolites. Epileptic Disord 2017; online early: Biomed Chromatogr 2017; online early: doi: 10.1684/epd.2017.0896: doi: 10.1002/bmc.3968:

Antihistamines Aripiprazole Diphenhydramine Cervello S, Cancel A, Boutet C, Schneider F, Giraux P, Namn Y, Schneider Y, Cui IH, Jesudian A. Laurent B, Fakra E. Diphenhydramine as a cause of drug-induced liver injury. Atypical permanent neurological sequelae after an acute Case Reports Hepatol 2017; 2017: 3864236. intoxication with lithium and aripiprazole. J Affect Disord 2017; 214: 97-9. Varma A, Ford L, Patel N, Vale JA.

Elimination half-life of diphenhydramine in overdose. Clin Toxicol 2017; online early: Clozapine doi: 10.1080/15563650.2017.1296153: Gee SH, Taylor DM, Shergill SS, Flanagan R, MacCabe JH. Effects of a smoking ban on clozapine plasma con- Antineoplastic drugs centrations in a nonsecure psychiatric unit. Ther Adv Psychopharmacol 2017; 7: 79-83. Capecitabine

Wilks AB, Saif MW. Wicinski M, Weclewicz MM, Mietkiewicz M, Malinowski B, First case of foot drop associated with capecitabine in a Grzesk E, Klonowska J. patient with thymidylate synthase polymorphism. Cureus 2017; 9: e995. Potential mechanisms of hematological adverse drug reactions in patients receiving clozapine in combination

with proton pump inhibitors. Melphalan J Psychiatr Pract 2017; 23: 114-20. Yanamandra U, Gupta S, Khadwal A, Malhotra P. Melphalan-induced cardiotoxicity: ventricular arrhythmias. Yousra H, Pierrick L, Laurent L, Daniele D. BMJ Case Rep 2016; doi: 10.1136/bcr-2016-218652: Interaction between clozapine and oxcarbazepine: a case

report. Methotrexate Ther Adv Psychopharmacol 2017; 7: 95-9. Adedokun C, O'Sullivan I, Murphy A, Muhammed R. Methotrexate acute accidental ingestion. Eur J Pediatr 2016; 175: 1532. Quetiapine Nincevic Z, Lasic D, Glavina T, Mikacic M, Carev M, Podrug K. Ajmani S, Preet Singh Y, Prasad S, Chowdhury A, Quetiapine poisoning associated with neuroleptic Aggarwal A, Lawrence A, Misra R, Mishra R, Agarwal V. malignant syndrome, rhabdomyolysis and renal failure: a Methotrexate-induced pancytopenia: a case series of 46 case report. patients. Psychiatr Danub 2017; 29: 84-6.

Antitussives Brimonidine Benzonatate Montague AJ, Bangh S, Cole JB. Bishop-Freeman SC, Shonsey EM, Friederich LW, Beuhler Bradycardia in a child after using brimonidine as MC, Winecker RE. toothpaste. JAMA Dermatol 2017; online early: Benzonatate toxicity: nothing to cough at. doi: 10.1001/jamadermatol.2016.6215: J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx021:

Antiviral drugs Caffeine Jones AW. Atazanavir Review of caffeine-related fatalities along with postmortem Roy-Chowdhury J, Roy-Chowdhury N, Listowsky I, blood concentrations in 51 poisoning deaths. Wolkoff AW. J Anal Toxicol 2017; 41: 161-72. Drug- and drug abuse–associated hyperbilirubinemia: experience with atazanavir. Lalanne L, Lutz P-E, Paille F. Clin Pharmacol Drug Dev 2017; 6: 140-6. Acute impact of caffeinated alcoholic beverages on cognition: a systematic review. Baclofen Prog Neuropsychopharmacol Biol Psychiatry 2017; online Boels D, Victorri-Vigneau C, Grall-Bronnec M, Touré A, early: doi: 10.1016/j.pnpbp.2017.03.007: Garnier A, Turcant A, Le Roux G. Baclofen and alcohol-dependent patients: a real risk of Mattioli AV, Pennella S, Manenti A, Farinetti A. severe self-poisoning. Energy drink overconsumption can trigger atrial fibrillation. Basic Clin Pharmacol Toxicol 2017; online early: doi: J Cardiovasc Med 2016; 17: 902-4. 10.1111/bcpt.12779: Reis R, Charehsaz M, Sipahi H, Ekici AI, Macit Ç, Akkaya Farah S, Chevillard L, Amiel-Niemann H, Labat L, Malissin H, Aydin A. I, Kubis N, Declèves X, Megarbane B. Energy drink induced lipid peroxidation and oxidative Baclofen poisoning in the intensive care unit: clinical features damage in rat liver and brain when used alone or combined and investigation of the relationships between the toxic with alcohol. encephalopathy and the plasma baclofen concentration. J Food Sci 2017; online early: Ann Intensive Care 2017; 7: 138-9. doi: 10.1111/1750-3841.13662:

Gee SW, Outsen S, Becknell B, Schwaderer AL. Cannabis (marijuana) Baclofen toxicity responsive to hemodialysis in a pediatric AbdelFattah KR, Edwards CR, Cripps MW, Minshall CT, patient with acute kidney injury. Phelan HA, Minei JP, Eastman AL. J Pediatr Intensive Care 2016; 5: 37-40. Cannabis use has negligible effects following severe traumatic injury. Khelfa M, M'rad A, Fredj H, Blel Y, Brahmi N. J Trauma Nurs 2017; 24: 141-5. Baclofen poisoning: an epidemiological retrospective study in intensive care unit. Nestoros JN, Vakonaki E, Tzatzarakis MN, Alegakis A, Ann Intensive Care 2017; 7: 138. Skondras MD, Tsatsakis AM. Long lasting effects of chronic heavy cannabis abuse. Léger M, Brunet M, Le Roux G, Boels D, Lerolle N. Am J Addict 2017; online early: doi: 10.1111/ajad.12529: Baclofen overdose: a retrospective multicentric study. Ann Intensive Care 2017; 7: 138. Sorensen CJ, DeSanto K, Borgelt L, Phillips KT, Monte AA. In response to letter to the editor regarding: Cannabinoid Nahar L, Smith A, Patel R, Andrews R, Paterson S. hyperemesis syndrome: diagnosis, pathophysiology, and Validated method for the screening and quantification of treatment-a systematic review. baclofen, gabapentin and pregabalin in human post- J Med Toxicol 2017; online early: doi: 10.1007/s13181- mortem whole blood using protein precipitation and liquid 017-0610-z: chromatography-tandem mass spectrometry. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx019: Clomiphene citrate Weller A, Daniel S, Koren G, Lunenfeld E, Levy A. Benzodiazepines The fetal safety of clomiphene citrate: a population based Dodds TJ. retrospective cohort study. Prescribed benzodiazepines and suicide risk: a review of Br J Obstet Gynaecol 2017; online early: the literature. doi: 10.1111/1471-0528.14651: Prim Care Companion CNS Disord 2017; 19: 16r02037. Cocaine Marinov P, Zlateva S, Bonchev G, Ivanov D, Georgiev K, Brunt TM, van den Berg J, Pennings E, Venhuis B. Sabeva Y, Yovcheva M. Adverse effects of levamisole in cocaine users: a review Acute poisoning with benzodiazepines and other and risk assessment. hypnotics: etiologic cause, sex/age distribution and clinical Arch Toxicol 2017; online early: doi: 10.1007/s00204-017- outcome. 1947-4: J IMAB Annu Proc Sci Pap 2016; 22: 1371-4. Miller MM, Meyer AE, Sprowles JL, Sable HJ. Sun EC, Dixit A, Humphreys K, Darnall BD, Baker LC, Cocaine self-administration in male and female rats Mackey S. perinatally exposed to PCBs: evaluating drug use in an Association between concurrent use of prescription opioids animal model of environmental contaminant exposure. and benzodiazepines and overdose: retrospective analysis. Exp Clin Psychopharmacol 2017; online early: Br Med J 2017; 356: j760. doi: 10.1037/pha0000113:

Scherer JN, Fiorentin TR, Sousa TR, Limberger RP, Jones JD, Campbell A, Metz VE, Comer SD. Pechansky F. No evidence of compensatory drug use risk behavior Oral fluid testing for cocaine: analytical evaluation of two among heroin users after receiving take-home naloxone. point-of-collection drug screening devices. Addict Behav 2017; 71: 104-6. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx018: Hydroxychloroquine Turillazzi E, Cerretani D, Cantatore S, Fiaschi AI, Frati P, Espandar G, Moghimi J, Ghorbani R, Pourazizi M, Seiri M- Micheli L, Neri M, Cipolloni L, Di Paolo M, Pinchi E, Riezzo A, Khosravi S. I, Santurro A, Vullo A, Fineschi V. Retinal toxicity in patients treated with hydroxychloroquine: Myocardial oxidative damage is induced by cardiac Fas- a cross-sectional study. dependent and mitochondria-dependent apoptotic pathways Med Hypothesis Discov Innov Ophthalmol 2016; 5: 41-6. in human cocaine-related overdose. Sci Rep 2017; 7: 44262. Levamisole Brunt TM, van den Berg J, Pennings E, Venhuis B. Desomorphine (Krokodil) Adverse effects of levamisole in cocaine users: a review Neves JF, Alves EA, Soares JX, Cravo SM, Silva AMS, Pereira and risk assessment. Netto AD, Carvalho F, Dinis-Oliveira RJ, Afonso CM. Arch Toxicol 2017; online early: doi: 10.1007/s00204- Data analysis of "krokodil" samples obtained by street-like 017-1947-4: synthesis. Data Brief 2016; 6: 83-8. Lithium Cervello S, Cancel A, Boutet C, Schneider F, Giraux P, Gamma hydroxybutyrate Laurent B, Fakra E. Busardò FP, Pichini S. Atypical permanent neurological sequelae after an acute The everlasting issue of GHB cut-offs in biological samples: intoxication with lithium and aripiprazole. how important it is to be careful when interpreting values. J Affect Disord 2017; 214: 97-9. Forensic Sci Int 2017; online early: doi: 10.1016/j.forsciint.2017.02.022: Hanak AS, Chevillard L, Lebeau R, Risède P, Laplanche JL, Benturquia N, Mégarbane B. Dijkstra BAG, Kamal R, van Noorden MS, de Haan H, Neurobehavioral effects of lithium in the rat: investigation of Loonen AJM, De Jong CAJ. the effect/concentration relationships and the contribution Detoxification with titration and tapering in gamma- of the poisoning pattern. hydroxybutyrate (GHB) dependent patients: the Dutch Prog Neuropsychopharmacol Biol Psychiatry 2017; 76: GHB monitor project. 124-33. Drug Alcohol Depend 2017; 170: 164-73.

Vodovar D, Mégarbane B. Kapitány-Fövény M, Zacher G, Posta J, Demetrovics Z. Do not forget gastrointestinal decontamination in the early GHB-involved crimes among intoxicated patients. management of lithium poisoning. Forensic Sci Int 2017; 275: 23-9. Basic Clin Pharmacol Toxicol 2017; online early: doi: 10.1111/bcpt.12758: Herbal medicines, ethnic remedies and dietary supplements Zamani N, Paeezi M, Hassanian-Moghaddam H. Letsyo E, Jerz G, Winterhalter P, Beuerle T. Response to: Do not forget gastrointestinal decontamination Toxic pyrrolizidine alkaloids in herbal medicines commonly in the early management of lithium poisoning. used in Ghana. Basic Clin Pharmacol Toxicol 2017; online early: J Ethnopharmacol 2017; 202: 154-61. doi: 10.1111/bcpt.12759:

Lunsford KE, Bodzin AS, Reino DC, Wang HL, Busuttil RW. Loperamide Dangerous dietary supplements: Garcinia cambogia- Bhatti Z, Norsworthy J, Szombathy T. associated hepatic failure requiring transplantation. Loperamide metabolite-induced cardiomyopathy and QTc World J Gastroenterol 2016; 22: 10071-6. prolongation. Clin Toxicol 2017; online early: Heroin (diacetylmorphine) doi: 10.1080/15563650.2017.1304555: Al-Tayyib A, Koester S, Langegger S, Raville L. Heroin and methamphetamine injection: an emerging Nattel S. drug use pattern. An emerging malignant arrhythmia epidemic due to Subst Use Misuse 2017; online early: loperamide abuse: underlying mechanisms and clinical doi: 10.1080/10826084.2016.1271432: relevance. JACC Clin Electrophysiol 2016; 2: 790-2. Bode AD, Singh M, Andrews J, Kapur GD, Baez AA. Fentanyl laced heroin and its contribution to a spike in Methylphenidate heroin overdose in Miami-Dade County. Ercan ES, Inci SB, Ipci M. Am J Emerg Med 2017; online early: Is there an effect of methylphenidate on thrombocytopenia? doi: 10.1016/j.ajem.2017.02.043: J Clin Psychopharmacol 2017; online early: doi: 10.1097/JCP.0000000000000690: Høiseth G, Gottås A, Berg T, Arnestad M, Halvorsen PS, Bachs LC. Urinary kinetics of heroin metabolites in pigs shortly after Muscle relaxants intake. Cyclobenzaprine J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx017: Nocera M.

A teenage girl with altered mental status and sinus Designer benzodiazepines tachycardia. Tomková J, Švidrnoch M, Maier V, Ondra P. Clin Pediatr Emerg Med 2016; 17: 312-6. Analysis of selected designer benzodiazepines by UHPLC with high-resolution time-of-flight mass spectrometry and Nalmefene the estimation of their partition coefficients by micellar Franchitto N, Jullian B, Salles J, Pelissier F, Rolland B. electrokinetic chromatography. Management of precipitated opiate withdrawal syndrome J Sep Sci 2017; online early: doi: 10.1002/jssc.201700069: induced by nalmefene mistakenly prescribed in opiate- dependent patients: a review for clinicians. Designer opioids Expert Opin Drug Metab Toxicol 2017; online early: doi: Helander A, Bäckberg M, Signell P, Beck O. 10.1080/17425255.2017.1312340: Intoxications involving acrylfentanyl and other novel designer fentanyls – results from the Swedish STRIDA Naltrexone project. Dadpour B, Gholoobi A, Tajoddini S, Habibi A. Clin Toxicol 2017; online early: Acute myocardial infarction following naltrexone doi: 10.1080/15563650.2017.1303141: consumption; a case report. Emergency 2017; 5: e45. Phenethylamines McGonigal MK, Wilhide JA, Smith PB, Elliott NM, Dorman FL. Nicotine Analysis of synthetic phenethylamine street drugs using direct sample analysis coupled to accurate mass time of Benowitz NL, Fraiman JB. flight mass spectrometry. Cardiovascular effects of electronic cigarettes. Forensic Sci Int 2017; 275: 83-9. Nat Rev Cardiol 2017; online early: doi: 10.1038/nrcardio.2017.36: Rajotte JW, Palmentier J-PFF, Wallage HR.

Drug recognition evaluation and chemical confirmation of Maina G, Castagnoli C, Ghione G, Passini V, Adami G, a 25C-NBOMe-impaired driver. Larese Filon F, Crosera M. J Forensic Sci 2017; online early: doi: 10.1111/1556- Skin contamination as pathway for nicotine intoxication in 4029.13433: vapers.

Toxicol In Vitro 2017; 41: 102-5. Synthetic cannabinoids Seo AD, Kim DC, Yu HJ, Kang MJ. Bassirnia A, Medrano B, Monte A, Calelo D, Manini AF, Accidental ingestion of E-cigarette liquid nicotine in a 15- Perkel C, Galynker I, Hurd Y. month-old child: an infant mortality case of nicotine Synthetic cannabinoids (SC) association with psychosis intoxication. and agitation. Korean J Pediatr 2016; 59: 490-3. Neuropsychopharmacology 2016; 41: S274-S275.

Weiss D, Tomasallo CD, Meiman JG, Creswell PD, Cairns R, Brown JA, Gunja N, Buckley NA. Melstrom PC, Gummin DD, Patel DJ, Michaud NT, Sebero The impact of Australian legislative changes on synthetic HA, Anderson HA. cannabinoid exposures reported to the New South Wales Electronic cigarette exposure: calls to Wisconsin poison Poisons Information Centre. Int J Drug Policy 2017; 43: 74-82. control centers, 2010–2015. Wis Med J 2016; 115: 306-10. Carlier J, Diao X, Scheidweiler KB, Huestis MA. Distinguishing intake of new synthetic cannabinoids ADB- Novel psychoactive substances PINACA and 5F-ADB-PINACA with human hepatocyte Champeau W, Eiden C, Gambier J, Peyriere H. metabolites and high-resolution mass spectrometry. Methoxphenidine use disorder: first case notified to the Clin Chem 2017; online early: French addictovigilance network. doi: 10.1373/clinchem.2016.267575: J Clin Psychopharmacol 2017; online early: doi: 10.1097/JCP.0000000000000684: Diao X, Carlier J, Zhu M, Pang S, Kronstrand R, Scheidweiler KB, Huestis MA. Johansson A, Lindstedt D, Roman M, Thelander G, Nielsen EI, In vitro and in vivo human metabolism of a new synthetic Lennborn U, Sandler H, Rubertsson S, Ahlner J, Kronstrand R, cannabinoid NM-2201 (CBL-2201). Kugelberg FC. Forensic Toxicol 2017; 35: 20-32. A non-fatal intoxication and seven deaths involving the dissociative drug 3-MeO-PCP. Fort C, Jourdan T, Kemp J, Curtis B. Forensic Sci Int 2017; 275: 76-82. Stability of synthetic cannabinoids in biological specimens: analysis through liquid chromatography tandem mass Salomone A, Palamar JJ, Gerace E, Di Corcia D, Vincenti M. spectrometry. Hair testing for drugs of abuse and new psychoactive J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx015: substances in a high-risk population. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx020: Haden M, Wood DM, Dargan PI. The impact of the Psychoactive Substances Act 2016 on Vallersnes OM, Persett PS, Øiestad EL, Karinen R, the online availability of MDMB-CHMICA. Heyerdahl F, Hovda KE. QJM 2017; online early: doi: 10.1093/qjmed/hcx045: Underestimated impact of novel psychoactive substances: laboratory confirmation of recreational drug toxicity in Lam RPK, Tang MHY, Leung SC, Chong YK, Tsui MSH, Oslo, Norway. Mak TWL. Clin Toxicol 2017; online early: Supraventricular tachycardia and acute confusion following doi: 10.1080/15563650.2017.1312002: ingestion of e-cigarette fluid containing AB-FUBINACA and

ADB-FUBINACA: a case report with quantitative analysis of Chwistek M, Wolf M. serum drug concentrations. Naloxone for outpatients at risk of opioid overdose #328. Clin Toxicol 2017; online early: J Palliat Med 2017; online early: doi: 10.1080/15563650.2017.1307385: doi: 10.1089/jpm.2017.0087:

Moeller S, Lücke C, Struffert T, Schwarze B, Gerner ST, Colomb S, Bourrain JL, Bonardel N, Chiriac A, Demoly P. Schwab S, Köhrmann M, Machold K, Philipsen A, Müller HH. Occupational opiate contact dermatitis. Ischemic stroke associated with the use of a synthetic Contact Derm 2017; 76: 240-1. cannabinoid (spice). Asian J Psychiatr 2017; 25: 127-30. Duvivier H, Gustafson S, Greutman M, Jangchup T, Harden AK, Reinhard A, Warshany K. Synthetic cathinones Indian Health Service pharmacists engaged in opioid Romanek K, Stenzel J, Schmoll S, Schrettl V, Geith S, Eyer safety initiatives and expanding access to naloxone. F, Rabe C. J Am Pharm Assoc (Wash ) 2017; 57: S135-S140.

Synthetic cathinones in Southern Germany – characteristics of users, substance-patterns, co-ingestions, Franchitto N, Jullian B, Salles J, Pelissier F, Rolland B. and complications. Management of precipitated opiate withdrawal syndrome Clin Toxicol 2017; online early: induced by nalmefene mistakenly prescribed in opiate- doi: 10.1080/15563650.2017.1301463: dependent patients: a review for clinicians. Expert Opin Drug Metab Toxicol 2017; online early: doi: Stanciu CN, Penders TM, Gnanasegaram SA, Pirapakaran 10.1080/17425255.2017.1312340: E, Padda JS, Padda JS. The behavioral profile of methylenedioxypyrovalerone Gaither JR, Leventhal JM, Ryan SA, Camenga DR. National trends in hospitalizations for opioid poisonings (MDPV) and alpha-pyrrolidinopentiophenone (PVP) – A systematic review. among children and adolescents, 1997 to 2012. Curr Drug Abuse Rev 2017; online early: JAMA Pediatr 2016; 170: 1195-201. doi: 10.2174/1874473710666170321122226: Heavey SC, Burstein G, Moore C, Homish GG. Overdose education and naloxone distribution program Tryptamines attendees: who attends, what do they know, and how do Wagmann L, Brandt SD, Kavanagh PV, Maurer HH, they feel? Meyer MR. J Public Health Manag Pract 2017; online early: doi: In vitro monoamine oxidase inhibition potential of alpha- 10.1097/PHH.0000000000000538: methyltryptamine analog new psychoactive substances for assessing possible toxic risks. Nielsen S, Peacock A, Lintzeris N, Bruno R, Larance B, Toxicol Lett 2017; 272: 84-93. Degenhardt L. Knowledge of opioid overdose and attitudes to supply of NSAIDs take-home naloxone among people with chronic Ibuprofen noncancer pain prescribed opioids. Pain Med 2017; online early: doi: 10.1093/pm/pnx021: Salmerón-Fernández MJ, Urrutia-Maldonado E, Abril-

Molina A, Martín-García JA, Ales-Palmer ML, Gomez-Luque Oliva EM, Christopher ML, Wells D, Bounthavong M, JM, Martin-Massot R, Osorio-Camara JM, Ocete-Hita E. Harvey M, Himstreet J, Emmendorfer T, Valentino M, Ibuprofen-induced hepatotoxicity in paediatric population. Franchi M, Goodman F, Trafton JA. Eur J Pediatr 2016; 175: 1620. Opioid overdose education and naloxone distribution:

development of the veterans health administration's Opioids national program. Abrahamsson T, Berge J, Öjehagen A, Håkansson A. J Am Pharm Assoc (Wash ) 2017; 57: S168-S179.e4. Benzodiazepine, z-drug and pregabalin prescriptions and mortality among patients in opioid maintenance treatment— Pergolizzi JV, Jr., LeQuang JA, Berger GK, Raffa RB. A nation-wide register-based open cohort study. The basic pharmacology of opioids informs the opioid Drug Alcohol Depend 2017; 174: 58-64. discourse about misuse and abuse: a review. Pain Ther 2017; online early: doi: 10.1007/s40122-017- Allen JD, Casavant MJ, Spiller HA, Chounthirath T, Hodges 0068-3: NL, Smith GA. Prescription opioid exposures among children and Shi CR, Kandola MS, Tobey M, Singer E. adolescents in the United States: 2000–2015. Managing opioid withdrawal for hospital patients in Pediatrics 2017; online early: doi: 10.1542/peds.2016- custody. 3382: Hastings Centre Report 2017; 47: 9-10.

Barry T, Klimas J, Tobin H, Egan M, Bury G. Srivastava A, Kahan M, Nader M. Opiate addiction and overdose: experiences, attitudes, Primary care management of opioid use disorders: and appetite for community naloxone provision. abstinence, methadone, or buprenorphine-naloxone? Br J Gen Pract 2017; online early: Can Fam Physician 2017; 63: 200-5. doi: 10.3399/bjgp17X689857: Sun EC, Dixit A, Humphreys K, Darnall BD, Baker LC, Cauley CE, Anderson G, Haynes AB, Menendez M, Mackey S. Bateman BT, Ladha K. Association between concurrent use of prescription opioids Predictors of in-hospital postoperative opioid overdose and benzodiazepines and overdose: retrospective analysis. after major elective operations: a nationally representative Br Med J 2017; 356: j760. cohort study. Ann Surg 2017; 265: 702-8. Wang JJ, Villeneuve E, Gosselin S.

Opioid overdose risk in low-wage online workers. Eleven years of children methadone poisoning in a referral Pain Med 2017; online early: doi: 10.1093/pm/pnx003: center: a review of 453 cases. J Opioid Manag 2017; 13: 27-36. Winstanley EL, Mashni R, Schnee S, Miller N, Mashni SM. The development and feasibility of a pharmacy-delivered Hong J, Lee J, Totouom-Tangho H, Dunn NR, Swift RG. opioid intervention in the emergency department. Methadone-induced hyperhidrosis treated with oxybutynin. J Am Pharm Assoc (Wash ) 2017; 57: S87-S91. J Addict Med 2017; online early: doi: 10.1097/ADM.0000000000000300: Zedler BK, Saunders WB, Joyce AR, Vick CC, Murrelle EL. Validation of a screening risk index for serious prescription Schwartz L, Mercurio-Zappala M, Howland MA, Hoffman opioid-induced respiratory depression or overdose in a US RS, Su MK. commercial health plan claims database. Unintentional methadone and buprenorphine exposures in Pain Med 2017; online early: doi: 10.1093/pm/pnx009: children: developing prevention messages. J Am Pharm Assoc (Wash ) 2017; 57: S83-S86. Buprenorphine Richards S, Torre L, Lawther B. Paracetamol (acetaminophen) Buprenorphine-related complications in elderly hospitalised Bateman DN, Dear JW. patients: a case series. Should we treat very large paracetamol overdose Anaesth Intensive Care 2017; 45: 256-61. differently? Br J Clin Pharmacol 2017; online early: Schwartz L, Mercurio-Zappala M, Howland MA, Hoffman doi: 10.1111/bcp.13279: RS, Su MK. Unintentional methadone and buprenorphine exposures in Canayakin D, Bayir Y, Kilic Baygutalp N, Sezen Karaoglan children: developing prevention messages. E, Atmaca HT, Kocak Ozgeris FB, Keles MS, Halici Z. J Am Pharm Assoc (Wash ) 2017; 57: S83-S86. Paracetamol-induced nephrotoxicity and oxidative stress in rats: the protective role of Nigella sativa. Pharm Biol 2016; 54: 2082-91. Carfentanil Wong B, Perkins MW, Tressler J, Rodriguez A, Devorak J, Jiang L, Ke M, Yue S, Xiao W, Yan Y, Deng X, Ying Q-L, Li J, Sciuto AM. Ke B. Effects of inhaled aerosolized carfentanil on real-time Blockade of Notch signaling promotes acetaminophen- physiological responses in mice: a preliminary evaluation induced liver injury. of naloxone. Immunol Res 2017; online early: doi: 10.1007/s12026- Inhal Toxicol 2017; 29: 65-74. 017-8913-3:

Codeine Mallet M, Haq M, Tripon S, Bernard M, Benosman H, Fais P, Pigaiani N, Cecchetto G, Montisci M, Gottardo R, Thabut D, Rudler M. Viel G, Pascali JP, Tagliaro F. Elevated procalcitonin is associated with bacterial infection "Tampering to death": A fatal codeine intoxication due to during acute liver failure only when unrelated to a homemade purification of a medical formulation. acetaminophen intoxication. J Forensic Sci 2017; online early: doi: 10.1111/1556- Eur J Gastroenterol Hepatol 2017; online early: doi: 4029.13492: 10.1097/MEG.0000000000000862:

Fentanyl Orbach SM, Cassin ME, Ehrich MF, Rajagopalan P. Investigating acetaminophen hepatotoxicity in multi- Bode AD, Singh M, Andrews J, Kapur GD, Baez AA. cellular organotypic liver models. Fentanyl laced heroin and its contribution to a spike in Toxicol In Vitro 2017; online early: heroin overdose in Miami-Dade County. doi: 10.1016/j.tiv.2017.03.008: Am J Emerg Med 2017; online early: doi: 10.1016/j.ajem.2017.02.043: Helander A, Bäckberg M, Signell P, Beck O. Proton pump inhibitors Intoxications involving acrylfentanyl and other novel Wicinski M, Weclewicz MM, Mietkiewicz M, Malinowski B, designer fentanyls – results from the Swedish STRIDA Grzesk E, Klonowska J. project. Potential mechanisms of hematological adverse drug Clin Toxicol 2017; online early: reactions in patients receiving clozapine in combination doi: 10.1080/15563650.2017.1303141: with proton pump inhibitors. J Psychiatr Pract 2017; 23: 114-20. Mercado MC, Sumner SA, Spelke MB, Bohm MK, Sugerman DE, Stanley C. Esomeprazole Increase in drug overdose deaths involving fentanyl— Thomas B, Mohamed M, Al HM, Awwad FAY, Wahba RM, Rhode Island, January 2012–March 2014. Hassan SB, Omar K, El KW, Rouf PA. Pain Med 2017; online early: doi: 10.1093/pm/pnx015: A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis. Phua CK, Wee A, Lim A, Abisheganaden J, Verma A. Clin Pharmacol 2016; 8: 199-202. Fentanyl-induced chest wall rigidity syndrome in a routine bronchoscopy. Psychotropic drugs Respir Med Case Rep 2017; 20: 205-7. Okumura Y, Nishi D. Risk of recurrent overdose associated with prescribing Methadone patterns of psychotropic medications after nonfatal Hassanian-Moghaddam H, Hakiminejhad M, Farnaghi F, overdose. Mirafzal A, Zamani N, Kabir A. Neuropsychiatr Dis Treat 2017; 13: 653-65.

Rivastigmine Crowley R, Kirschner N, Dunn AS, Bornstein SS, for the Saz EU, Yurtseven A, Kilinç MA, Sari Y, Agin H. Health and Public Policy Committee of the American The first use of pralidoxime in a child with rivastigmine College of Physicians. poisoning. Health and public policy to facilitate effective prevention Pediatr Emerg Care 2017; online early: and treatment of substance use disorders involving illicit doi: 10.1097/PEC.0000000000001086: and prescription drugs: an American College of Physicians Position Paper. Ann Intern Med 2017; online early: doi: 10.7326/M16- Salicylates 2953: Phan K, Moore JM, Griessenauer CJ, Ogilvy CS, Thomas AJ. Aspirin and risk of subarachnoid hemorrhage: systematic Evoy KE, Morrison MD, Saklad SR. review and meta-analysis. Abuse and misuse of pregabalin and gabapentin. Stroke 2017; online early: Drugs 2017; 77: 403-26. doi: 10.1161/STROKEAHA.116.015674:

Hirvioja J, Joutsa J, Wahlsten P, Korpela J. Vaz S, Jalles F, Santo RE, Boto L, Rios J, Camilo C, Recurrent paraparesis and death of a patient with 'whippet' Abecasis F, Vieira M. abuse. "Ketoacidosis, not always diabetic..". Oxf Med Case Reports 2016; 2016: 41-3. Cogent Med 2016; 3: 66-7.

Jain R, Verma A. Sedatives Laboratory approach for diagnosis of toluene-based Abrahamsson T, Berge J, Öjehagen A, Håkansson A. inhalant abuse in a clinical setting. Benzodiazepine, z-drug and pregabalin prescriptions and J Pharm Bioallied Sci 2016; 8: 18-22. mortality among patients in opioid maintenance treatment— A nation-wide register-based open cohort study. Liakoni E, Müller S, Stoller A, Ricklin M, Liechti ME, Drug Alcohol Depend 2017; 174: 58-64. Exadaktylos AK. Presentations to an urban emergency department in Bern, Chloral hydrate Switzerland associated with acute recreational drug Mataftsi A, Malamaki P, Prousali E, Riga P, Lathyris D, toxicity. Chalvatzis NT, Haidich A-B. Scand J Trauma Resusc Emerg Med 2017; 25: 26. Safety and efficacy of chloral hydrate for procedural sedation in paediatric ophthalmology: a systematic review Matsusue A, Ishikawa T, Michiue T, Waters B, Hara K, and meta-analysis. Kashiwagi M, Takayama M, Ikematsu N, Kubo S-I. Br J Ophthalmol 2017; online early: Association between cerebrospinal fluid dopamine doi: 10.1136/bjophthalmol-2016-309449: concentrations and catechol-O-methyltransferase gene polymorphisms in forensic autopsy cases of SSRIs and SNRIs methamphetamine abusers. Forensic Sci Int 2017; 270: 159-64. Kelly JM, Rubenfeld GD, Masson N, Min A, Adhikari NKJ.

Using selective serotonin reuptake inhibitors and serotonin- norepinephrine reuptake inhibitors in critical care: a Nanavati A, Herlitz LC. systematic review of the evidence for benefit or harm. Tubulointerstitial injury and drugs of abuse. Crit Care Med 2017; online early: Adv Chronic Kidney Dis 2017; 24: 80-5. doi: 10.1097/CCM.0000000000002308: Nattel S. An emerging malignant arrhythmia epidemic due to Steroids loperamide abuse: underlying mechanisms and clinical Ponzetto F, Boccard J, Baume N, Kuuranne T, Rudaz S, relevance. Saugy M, Nicoli R. JACC Clin Electrophysiol 2016; 2: 790-2. High-resolution mass spectrometry as an alternative detection method to tandem mass spectrometry for the Park TW. analysis of endogenous steroids in serum. Debate: Are benzodiazepines appropriate treatments for J Chromatogr B Biomed Sci Appl 2017; 1052: 34-42. patients with substance use disorders? Yes.

J Addict Med 2017; 11: 87-9. Betamethasone Borges CS, Pacheco TL, Guerra MT, Barros AL, Silva PV, Salehi F, Hassanzadeh Taheri MM, Riasi H, Mehrpour O. Missassi G, da Silva KP, Anselmo-Franci JA, Pupo AS, Recurrent syncope following substance abuse; a case Kempinas WdG. report. Reproductive disorders in female rats after prenatal Emergency 2017; 5: e47. exposure to betamethasone. J Appl Toxicol 2017; online early: doi: 10.1002/jat.3457: Shattuck B, Livingstone J. A case of cardiac tamponade due to an isolated abscess in Substance abuse the ascending aorta of a pregnant woman with a history Blundell MS, Dargan PI, Wood DM. of intravenous substance abuse. The dark cloud of recreational drugs and vaping. Forensic Sci Med Pathol 2017; online early: QJM 2017; online early: doi: 10.1093/qjmed/hcx049: doi: 10.1007/s12024-017-9856-7:

Boumparis N, Karyotaki E, Schaub MP, Cuijpers P, Riper H. Srivastava A, Kahan M, Nader M. Internet interventions for adult illicit substance users: a Primary care management of opioid use disorders: meta-analysis. abstinence, methadone, or buprenorphine-naloxone? Addiction 2017; online early: doi: 10.1111/add.13819: Can Fam Physician 2017; 63: 200-5.

Tucci JR, Whitford GM, McAlister WH, Novack DV, Mumm Risk assessment of fluoride exposure in drinking water of S, Keaveny TM, Whyte MP. Tunisia. Skeletal fluorosis due to inhalation abuse of a Chemosphere 2017; 177: 102-8. difluoroethane-containing computer cleaner. J Bone Miner Res 2016; 32: 188-95. McGrory ER, Brown C, Bargary N, Williams NH, Mannix A, Zhang C, Henry T, Daly E, Nicholas S, Petrunic BM, Lee M, Vitamins Morrison L. Arsenic contamination of drinking water in Ireland: a Folic acid spatial analysis of occurrence and potential risk. Devnath GP, Kumaran S, Rajiv R, Shaha KK, Nagaraj A. Sci Total Environ 2017; 579: 1863-75. Fatal folic acid toxicity in humans. J Forensic Sci 2017; online early: doi: 10.1111/1556- 4029.13489: CHEMICALS General Hoet P, Rydzynski K, Vermeire T, Nair U, Talhout R, Testai CHEMICAL INCIDENTS AND E, SCENIHR Secretariat. POLLUTION Recommendations to the European Commission implementing a priority list of additives that should have Air pollution more stringent reporting requirements: the opinion of the Jacobs M, Zhang G, Chen S, Mullins B, Bell M, Jin L, Guo Scientific Committee on Emerging and Newly Identified Y, Huxley R, Pereira G. Health Risks (SCENIHR). The association between ambient air pollution and selected Tob Control 2017; online early: adverse pregnancy outcomes in China: a systematic review. doi: 10.1136/tobaccocontrol-2017-053642: Sci Total Environ 2017; 579: 1179-92.

Kermani M, Dowlati M, Jafari AJ, Kalantari RR. Abrin Health risks attributed to particulate matter of 2.5 microns Sant B, Lakshmana Rao PV, Nagar DP, Pant SC, Bhasker or less in Tehran air 2005-2014. ASB. J Kermanshah Univ Med Sci 2016; 20: 99-105. Evaluation of abrin induced nephrotoxicity by using novel renal injury markers. Macintyre HL, Heaviside C, Neal LS, Agnew P, Thornes J, Toxicon 2017; 131: 20-8. Vardoulakis S. Mortality and emergency hospitalizations associated with Acrylic adhesives atmospheric particulate matter episodes across the UK in Canellas E, Vera P, Nerin C. spring 2014. Migration assessment and the 'threshold of toxicological Environ Int 2016; 97: 108-16. concern' applied to the safe-design of an acrylic adhesive for food contact laminates. Naz S, Page A, Agho KE. Food Addit Contam Part A Chem Anal Control Expo Risk Household air pollution and under-five mortality in India Assess 2017; online early: (1992–2006). doi: 10.1080/19440049.2017.1308017: Environ Health 2016; 15: 54. Alcohol (ethanol) Ranathunga N, Perera P, Nandasena S, Sathiakumar N, Jurek T, Rorat M. Kasthuriratne A, Wikremasinghe R. Fatal accidents at work in agriculture associated with Effects of indoor air pollution from solid fuel combustion alcohol intoxication in Lower Silesia in Poland. on development of children under 5 years. Med Pr 2017; 68: 23-30. Cogent Med 2016; 3: 52-3. Lalanne L, Lutz P-E, Paille F. Chemical incidents Acute impact of caffeinated alcoholic beverages on Jung D, Kim J-A, Park M-S, Yim UH, Choi K. cognition: a systematic review. Human health and ecological assessment programs for Prog Neuropsychopharmacol Biol Psychiatry 2017; online Hebei Spirit oil spill accident of 2007: status, lessons, and early: doi: 10.1016/j.pnpbp.2017.03.007: future challenges. Chemosphere 2017; 173: 180-9. Poklis JL, Wolf CE, II, Peace MR. Ethanol concentration in 56 refillable electronic cigarettes Shumate AM, Taylor J, McFarland E, Tan C, Duncan MA. liquid formulations determined by headspace gas Medical response to a vinyl chloride release from a train chromatography with flame ionization detector (HS-GC- derailment: New Jersey, 2012. FID). Disaster Med Public Health Prep 2017; online early: doi: Drug Test Anal 2017; online early: doi: 10.1002/dta.2193: 10.1017/dmp.2016.191: Razvodovsky YE. Pollution and hazardous waste Fatal alcohol poisonings and traffic accidents in Russia. Alcohol Psychiatry Res 2016; 52: 115-24. Dai Y, Huo X, Zhang Y, Yang T, Li M, Xu X.

Elevated lead levels and changes in blood morphology and Reis R, Charehsaz M, Sipahi H, Ekici AI, Macit Ç, Akkaya H, erythrocyte CR1 in preschool children from an e-waste Aydin A. area. Energy drink induced lipid peroxidation and oxidative Sci Total Environ 2017; 592: 51-9. damage in rat liver and brain when used alone or combined with alcohol. Water pollution J Food Sci 2017; online early: Guissouma W, Hakami O, Al-Rajab AJ, Tarhouni J. doi: 10.1111/1750-3841.13662:

Santos C, Kieszak S, Wang A, Law R, Schier J, Wolkin A. Emergency carbon monoxide poisoning: clinical presentation Reported adverse health effects in children from ingestion and outcomes. of alcohol-based hand sanitizers - United States, 2011- Ann Intensive Care 2017; 7: 137. 2014. MMWR Morb Mortal Wkly Rep 2017; 66: 223-6. Nair AJ, Nandini M, Adappa S, Mahabala C. Carbon monoxide exposure among police officers working Schneider R, Jr., Bandiera S, Souza DG, Bellaver B, Caletti in a traffic dense region of Southern India. G, Quincozes-Santos A, Elisabetsky E, Gomez R. Toxicol Ind Health 2017; 33: 46-52. N-acetylcysteine prevents alcohol related neuroinflammation in rats. Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Neurochem Res 2017; online early: doi: 10.1007/s11064- Gladwin MT. 017-2218-8: Reply: Better studies are needed to guide treatment of carbon monoxide poisoning. Schröder J, Hamada S, Altiok E, Almalla M, Koutziampasi Am J Respir Crit Care Med 2017; 195: 694-5. C, Napp A, Keszei A, Hein M, Becker M. Detection of acute changes in left ventricular function by Yan W. myocardial deformation analysis after excessive alcohol Carbon monoxide, the silent killer, may have met its match. ingestion. Science 2016; 354: 1215. J Am Soc Echocardiogr 2017; 30: 235-43.e1. Corrosives Asbestos Nehrlich J, Klöcking H-P, Hentschel H, Lupp A. Barlow CA, Sahmel J, Paustenbach DJ, Henshaw JL. Oral chemical burns reported to the poisons information History of knowledge and evolution of occupational health centre in Erfurt, Germany, from 1997 to 2014. and regulatory aspects of asbestos exposure science: J Burn Care Res 2017; online early: 1900–1975. doi: 10.1097/BCR.0000000000000518: Crit Rev Toxicol 2017; online early: doi: 10.1080/10408444.2016.1258391: Cosmetics Desmedt B, Courselle P, De Beer JO, Rogiers V, Grosber Batteries M, Deconinck E, De Paepe K. Pigatto PD, Ronchi A, Pallotti F, Guzzi G. Overview of skin whitening agents with an insight into the Sudden death and toxic metals following ingestion of a illegal cosmetic market in Europe. button battery. J Eur Acad Dermatol Venereol 2016; 30: 943-50. Int J Legal Med 2017; online early: doi: 10.1007/s00414- 017-1572-z: Haraux E, Braun K, Buisson P, Stéphan-Blanchard E, Devauchelle C, Ricard J, Boudailliez B, Tourneux P, Gouron R, Chardon K. Botulinum toxin Maternal exposure to domestic hair cosmetics and França K, Kumar A, Fioranelli M, Lotti T, Tirant M, Roccia MG. occupational endocrine disruptors is associated with a The history of Botulinum toxin: from poison to beauty. higher risk of hypospadias in the offspring. Wien Med Wochenschr 2017; online early: Int J Environ Res Public Health 2017; 14: 27. doi: 10.1007/s10354-017-0553-7:

Szuch E, Caress JB, Paudyal B, Brashear A, Cartwright MS, Cyanide Strowd RE, III. Lavon O, Avrahami A, Eisenkraft A. Head drop after botox: electrodiagnostic evaluation of Effectiveness of cyanide; treatment in cyanide poisoning iatrogenic botulinum toxicity. as a function of the administration timing. Clin Neurol Neurosurg 2017; 156: 1-3. BMC Pharmacol Toxicol 2017; 18: 13.

Carbon dioxide Difluoroethane Podlewski R, Plotek W, Grzeskowiak M, Malkiewicz T, Tucci JR, Whitford GM, McAlister WH, Novack DV, Mumm Frydrysiak K, Zaba Z. S, Keaveny TM, Whyte MP. Carbon dioxide as a potential danger to medical rescue Skeletal fluorosis due to inhalation abuse of a teams at work - a case study. difluoroethane-containing computer cleaner. Med Pr 2017; 68: 135-8. J Bone Miner Res 2016; 32: 188-95.

Carbon monoxide Dioxins Anon. Abraham K. Number of deaths resulting from unintentional carbon Risks of dioxins resulting from high exposure via breast- monoxide poisoning,* by month and year - National Vital feeding? Statistics System, United States, 2010-2015. Arch Toxicol 2017; online early: doi: 10.1007/s00204- MMWR Morb Mortal Wkly Rep 2017; 66: 234. 017-1952-7:

Azarov I, Wang L, Rose JJ, Xu Q, Huang XN, Belanger A, E-cigarettes and e-liquids Wang Y, Guo L, Liu C, Ucer KB, McTiernan CF, O'Donnell Benowitz NL, Fraiman JB. CP, Shiva S, Tejero J, Kim-Shapiro DB, Gladwin MT. Cardiovascular effects of electronic cigarettes. Five-coordinate H64Q neuroglobin as a ligand-trap Nat Rev Cardiol 2017; online early: antidote for carbon monoxide poisoning. doi: 10.1038/nrcardio.2017.36: Sci Transl Med 2016; 8: 368ra173. Blundell MS, Dargan PI, Wood DM. Essaf F, M'rad A, Mejri O, Hmida MB, Thabet H, Blel Y, The dark cloud of recreational drugs and vaping. Brahmi N. QJM 2017; online early: doi: 10.1093/qjmed/hcx049:

Lam RPK, Tang MHY, Leung SC, Chong YK, Tsui MSH, Case report demonstrating the safe and effective means Mak TWL. of expanding the donor pool with livers recovered from Supraventricular tachycardia and acute confusion following brain-dead donors after ethylene glycol toxicity. ingestion of e-cigarette fluid containing AB-FUBINACA and Transplant Proc 2016; 48: 3064-6. ADB-FUBINACA: a case report with quantitative analysis of serum drug concentrations. Wu X, Lu G, Qi B, Wang R, Guo D, Liu X. Clin Toxicol 2017; online early: Antifreeze poisoning: a case report. doi: 10.1080/15563650.2017.1307385: Exp Ther Med 2016; 13: 701-4.

Maina G, Castagnoli C, Ghione G, Passini V, Adami G, Flame retardants Larese Filon F, Crosera M. Xiang P, Liu R-Y, Sun H-J, Yang Y-W, Cui X-Y, Ma LQ. Skin contamination as pathway for nicotine intoxication in vapers. Effects of novel brominated flame retardant TBPH and its Toxicol In Vitro 2017; 41: 102-5. metabolite TBMEHP on human vascular endothelial cells: Implication for human health risks.

Environ Res 2017; online early: Pankow JF, Kim K, McWhirter KJ, Luo W, Escobedo JO, Strongin RM, Duell AK, Peyton DH. doi: 10.1016/j.envres.2017.02.028: Benzene formation in electronic cigarettes. PLoS ONE 2017; 12: e0173055. Fluoride Guissouma W, Hakami O, Al-Rajab AJ, Tarhouni J. Poklis JL, Wolf CE, II, Peace MR. Risk assessment of fluoride exposure in drinking water of Ethanol concentration in 56 refillable electronic cigarettes Tunisia. liquid formulations determined by headspace gas Chemosphere 2017; 177: 102-8. chromatography with flame ionization detector (HS-GC- FID). Patel P, Zulf M, Yagnik B, Kajale N, Mandlik R, Khadilkar V, Drug Test Anal 2017; online early: Chiplonkar S, Phanse S, Patwardhan V, Joshi P, Patel A, doi: 10.1002/dta.2193: Khadilkar A. Association of dental and skeletal fluorosis with calcium Poklis JL, Mulder HA, Halquist MS, Wolf CE, Poklis A, intake and serum Vitamin D concentration in adolescents Peace MR. from a region endemic for fluorosis. The Blue Lotus flower (Nymphea caerulea) resin used in a Indian J Endocrinol Metab 2017; 21: 190-5. new type of electronic cigarette, the re-buildable dripping atomizer. Tucci JR, Whitford GM, McAlister WH, Novack DV, Mumm J Psychoactive Drugs 2017; online early: S, Keaveny TM, Whyte MP. doi: 10.1080/02791072.2017.1290304: Skeletal fluorosis due to inhalation abuse of a difluoroethane-containing computer cleaner. Seo AD, Kim DC, Yu HJ, Kang MJ. J Bone Miner Res 2016; 32: 188-95. Accidental ingestion of E-cigarette liquid nicotine in a 15- month-old child: an infant mortality case of nicotine intoxication. Fluoropolymers Korean J Pediatr 2016; 59: 490-3. Henke D, Campbell A, Bradberry SM, Sandilands EA, Thomas SHL, Thompson JP, Vale JA. Weiss D, Tomasallo CD, Meiman JG, Creswell PD, Melstrom Toxicity from fluoropolymer-containing grout, tile and PC, Gummin DD, Patel DJ, Michaud NT, Sebero HA, stone floor sealants reported to the UK National Poisons Anderson HA. Information Service 2009–2015. Electronic cigarette exposure: calls to Wisconsin poison Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1296154: control centers, 2010–2015. Wis Med J 2016; 115: 306-10. Fragrance chemicals Endocrine disrupting chemicals Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Haraux E, Braun K, Buisson P, Stéphan-Blanchard E, Jr., Buschmann J, Calow P, Dagli ML, Date M, Dekant W, Devauchelle C, Ricard J, Boudailliez B, Tourneux P, Deodhar C, Fryer AD, Joshi K, La Cava S, Lapczynski A, Gouron R, Chardon K. Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, Maternal exposure to domestic hair cosmetics and Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar occupational endocrine disruptors is associated with a Y, Tsang S, Wahler J. higher risk of hypospadias in the offspring. RIFM fragrance ingredient safety assessment, isotridecyl Int J Environ Res Public Health 2017; 14: 27. acetate, CAS registry number 69103-23-7. Food Chem Toxicol 2017; online early: Endotoxin doi: 10.1016/j.fct.2017.03.003:

Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Nishimura SL, Calfee CS, Matthay MA. Jr., Buschmann J, Calow P, Dagli ML, Date M, Dekant W, Cigarette smoke exposure worsens endotoxin-induced Deodhar C, Fryer AD, Joshi K, La Cava S, Lapczynski A, lung injury and pulmonary edema in mice. Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, Nicotine Tob Res 2017; online early: Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar doi: 10.1093/ntr/ntx062: Y, Tsang S, Wahler J. RIFM fragrance ingredient safety assessment, l- Ethylene glycol cyclocitronellene formate, CAS registry number 25225-08-5. Fujii MH, Gierlach J, Alami S, Ericksen C, Kashyap R, Orloff Food Chem Toxicol 2017; online early: MS, Marroquin CE. doi: 10.1016/j.fct.2017.02.035:

Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, A public health approach in responding to the spread of Jr., Buschmann J, Calow P, Dagli ML, Date M, Dekant W, helium suicide in Hong Kong. Deodhar C, Fryer AD, Joshi K, La Cava S, Lapczynski A, Crisis 2017; online early: doi: 10.1027/0227-5910/a000449: Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Methanol Y, Tsang S, Wahler J. Bezdicek O, Michalec J, Vaneckova M, Klempir J, Liskova I, RIFM fragrance ingredient safety assessment, isoamyl Seidl Z, Janikova B, Miovsky M, Hubacek J, Diblik P, hexanoate, CAS registry number 2198-61-0. Kuthan P, Pilin A, Kurcova I, Fenclova Z, Petrik V, Navratil Food Chem Toxicol 2017; online early: T, Pelclova D, Zakharov S, Ruzicka E. doi: 10.1016/j.fct.2017.03.040: Cognitive sequelae of methanol poisoning involve executive dysfunction and memory impairment in cross- Api AM, Belsito D, Bhatia S, Botelho D, Brown D, Bruze M, sectional and long-term perspective. Burton GA, Jr., Buschmann J, Calow P, Dagli ML, Date M, Alcohol 2017; 59: 27-35. Dekant W, Fryer AD, Kromidas L, Lalko J, La Cava S, Lapczynski A, Liebler DC, O'Brien D, Parakhia R, Patel A, Rulisek J, Balik M, Polak F, Waldauf P, Pelclova D, Penning TM, Politano VT, Ritacco G, Romine J, Salvito D, Belohlavek J, Zakharov S. Schultz TW, Shen J, Sipes IG, Thakkar Y. Cost-effectiveness of hospital treatment and outcomes of RIFM fragrance ingredient safety assessment, acute methanol poisoning during the Czech Republic mass isolongifolene ketone, CAS registry number 23787-90-8. poisoning outbreak. Food Chem Toxicol 2017; online early: J Crit Care 2017; online early: doi: 10.1016/j.fct.2017.02.034: doi: 10.1016/j.jcrc.2017.03.001:

Api AM, Belsito D, Bhatia S, Botelho D, Browne D, Bruze M, Ryu J, Lim KH, Ryu D-R, Lee HW, Yun JY, Kim S-W, Kim J- Burton GA, Jr., Buschmann J, Calow P, Dagli ML, Date M, H, Jung-Choi K, Kim H. Dekant W, Deodhar C, Fryer AD, Kromidas L, La Cava S, Lalko Two cases of methyl alcohol intoxication by sub-chronic J, Lapczynski A, Liebler DC, Miyachi Y, O'Brien D, Parakhia R, inhalation and dermal exposure during aluminum CNC Patel A, Penning TM, Politano VT, Ritacco G, Romine J, Salvito cutting in a small-sized subcontracted factory. D, Schultz TW, Shen J. Ann Occup Environ Med 2016; 28: 65. RIFM fragrance ingredient safety assessment, d- cyclocitronellene acetate, CAS registry number 25225-10-9. Zakharov S, Nurieva O, Kotikova K, Belacek J, Navratil T, Food Chem Toxicol 2017; online early: Pelclova D. doi: 10.1016/j.fct.2017.03.004: Positive serum ethanol concentration on admission to hospital as the factor predictive of treatment outcome in

acute methanol poisoning. Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Monatsh Chem 2017; 148: 409-19. Jr., Buschmann J, Calow P, Dagli ML, Date M, Dekant W,

Deodhar C, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, Naphthalene Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Tang KY. Y, Tsang S, Wahler J. A patient presented with dark brown urine after mothballs RIFM fragrance ingredient safety assessment, isoamyl powder ingestion. propionate, CAS registry number 105-68-0. Clin Toxicol 2017; online early: Food Chem Toxicol 2017; online early: doi: 10.1080/15563650.2017.1305110: doi: 10.1016/j.fct.2017.03.021: Nitrous oxide Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Jr., Hirvioja J, Joutsa J, Wahlsten P, Korpela J. Buschmann J, Calow P, Dagli ML, Dekant W, Fryer AD, La Recurrent paraparesis and death of a patient with 'whippet' Cava S, Lapczynski A, Liebler DC, O'Brien D, Parakhia R, Patel abuse. A, Penning TM, Ritacco G, Romine J, Salvito D, Schultz TW, Oxf Med Case Reports 2016; 2016: 41-3. Shen J, Sipes IG, Wahler J. RIFM Fragrance ingredient safety assessment, 6-acetyl- Perfluorinated compounds 1,1,2,4,4,7-hexamethyltetraline, CAS registry number Butenhoff JL, Olsen GW, Chang S. 21145-77-7. Toxicological response of Sprague Dawley rats from Food Chem Toxicol 2017; online early: inhalation exposure to perfluorooctane sulfonyl fluoride doi: 10.1016/j.fct.2017.03.019: (POSF). Toxicol Lett 2017; 271: 38-49. Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Jr., Buschmann J, Calow P, Dagli ML, Date M, Dekant W, Harris MH, Rifas-Shiman SL, Calafat AM, Ye X, Mora AM, Deodhar C, Fryer AD, Joshi K, La Cava S, Lapczynski A, Webster TF, Oken E, Sagiv SK. Liebler DC, O'Brien D, Parakhia R, Patel A, Penning TM, Predictors of per- and polyfluoroalkyl substance (PFAS) Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar plasma concentrations in 6-10 year old American children. Y, Tsang S, Wahler J. Environ Sci Technol 2017; online early: RIFM fragrance ingredient safety assessment, isoamyl doi: 10.1021/acs.est.6b05811: octanoate, CAS registry number 2035-99-6. Food Chem Toxicol 2017; online early: Oulhote Y, Steuerwald U, Debes F, Weihe P, Grandjean P. doi: 10.1016/j.fct.2017.02.036: Behavioral difficulties in 7-year old children in relation to developmental exposure to perfluorinated alkyl substances. Helium Environ Int 2016; 97: 237-45. Yip PSF, Cheng Q, Chang S-S, Lee EST, Lai C-SC, Chen F, Law Y-WF, Cheng TME, Chiu SM, Tse YLJ, Cheung K-WR, Petrol (gasoline) and petroleum oils Tse M-L, Morgan PR, Beh P. Jung D, Kim J-A, Park M-S, Yim UH, Choi K.

Human health and ecological assessment programs for Sodium nitrite Hebei Spirit oil spill accident of 2007: status, lessons, and Lee C, Jang EJ, Yum H, Choi YS, Hong J. future challenges. Unintentional mass sodium nitrite poisoning with a fatality. Chemosphere 2017; 173: 180-9. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1303142: Benzene Pankow JF, Kim K, McWhirter KJ, Luo W, Escobedo JO, Tattoo inks Strongin RM, Duell AK, Peyton DH. Serup J. Benzene formation in electronic cigarettes. From technique of tattooing to biokinetics and toxicology PLoS ONE 2017; 12: e0173055. of injected tattoo ink particles and chemicals. Curr Probl Dermatol 2017; 52: 1-17. Bromobenzene Yoshioka H, Nonogaki T, Fukuishi N, Shinohara Y, Hwang Serup J. G-W, Ohtani K, Miura N. How to diagnose and classify tattoo complications in the Chronotoxicity of bromobenzene-induced hepatic injury in clinic: a system of distinctive patterns. mice. Curr Probl Dermatol 2017; 52: 58-73. J Toxicol Sci 2017; 42: 251-8. Tobacco Diesel Al-Sawalha NA, Migdadi AM, Alzoubi KH, Khabour OF, Möhner M, Wendt A. Qinna NA. A critical review of the relationship between occupational Effect of waterpipe tobacco smoking on airway inflammation exposure to diesel emissions and lung cancer risk. in murine model of asthma. Crit Rev Toxicol 2017; 47: 185-224. Inhal Toxicol 2017; 29: 46-52.

Phthalates Gee SH, Taylor DM, Shergill SS, Flanagan R, MacCabe JH. Effects of a smoking ban on clozapine plasma Chen C-C, Wang S-L, Wu M-T, Wang Y-H, Huang P-C, Chen concentrations in a nonsecure psychiatric unit. B-H, Sun C-W, Ho C-K, Shih Y-C, Shiu M-N, Pan W-H, Chen Ther Adv Psychopharmacol 2017; 7: 79-83. M-L, Lee C-C, Hsiung C-A.

Exposure estimation for risk assessment of the phthalate Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, incident in Taiwan. Nishimura SL, Calfee CS, Matthay MA. PLoS ONE 2016; 11: e0151070. Cigarette smoke exposure worsens endotoxin-induced

lung injury and pulmonary edema in mice. Silva MJ, Wong L-Y, Samandar E, Preau JL, Calafat AM, Ye X. Nicotine Tob Res 2017; online early: Exposure to di-2-ethylhexyl terephthalate in a convenience doi: 10.1093/ntr/ntx062: sample of U.S. adults from 2000 to 2016.

Arch Toxicol 2017; online early: doi: 10.1007/s00204- Hoet P, Rydzynski K, Vermeire T, Nair U, Talhout R, Testai 017-1956-3: E, SCENIHR Secretariat.

Recommendations to the European Commission Polybrominated diphenyl ethers implementing a priority list of additives that should have Abou-Elwafa Abdallah M, Zaky AH, Covaci A. more stringent reporting requirements: the opinion of the Levels and profiles of organohalogenated contaminants in Scientific Committee on Emerging and Newly Identified human blood from Egypt. Health Risks (SCENIHR). Chemosphere 2017; 176: 266-72. Tob Control 2017; online early: doi: 10.1136/tobaccocontrol-2017-053642: Polychlorinated biphenyls Lee W, Lee S, Roh J, Won J-U, Yoon J-H. Abou-Elwafa Abdallah M, Zaky AH, Covaci A. The association between involuntary smoking exposure with Levels and profiles of organohalogenated contaminants in urine cotinine level and blood cadmium level in general non- human blood from Egypt. smoking populations. Chemosphere 2017; 176: 266-72. J Korean Med Sci 2017; 32: 568-75.

Miller MM, Meyer AE, Sprowles JL, Sable HJ. Niaz K, Maqbool F, Khan F, Bahadar H, Ismail Hassan F, Cocaine self-administration in male and female rats Abdollahi M. perinatally exposed to PCBs: evaluating drug use in an Smokeless tobacco (paan and gutkha) consumption and animal model of environmental contaminant exposure. its prevalence contributing toward oral cancer. Exp Clin Psychopharmacol 2017; online early: doi: Epidemiol Health 2017; online early: 10.1037/pha0000113: doi: 10.4178/epih.e2017009:

Radiation Yu C, Zhang Z, Liu Y, Zong Y, Chen Y, Du X, Chen J, Feng Harrison J, Fell T, Leggett R, Lloyd D, Puncher M, S, Hu J, Cui S, Lu G. Youngman M. Toxicity of smokeless tobacco extract after 184-day The polonium-210 poisoning of Mr Alexander Litvinenko. repeated oral administration in rats. J Radiol Prot 2017; 37: 266-78. Int J Environ Res Public Health 2016; 13: 281.

Smoke Toluene Legrand M, Michel T. Jain R, Verma A. Empiric use of hydroxocobalamin in patients with smoke Laboratory approach for diagnosis of toluene-based inhlation injury: not so fast! inhalant abuse in a clinical setting. Burns 2016; online early: doi: 10.1016/j.burns.2016.11.017: J Pharm Bioallied Sci 2016; 8: 18-22.

Triclosan Arsenic Ruszkiewicz JA, Li S, Rodriguez MB, Aschner M. McGrory ER, Brown C, Bargary N, Williams NH, Mannix A, Is triclosan a neurotoxic agent? Zhang C, Henry T, Daly E, Nicholas S, Petrunic BM, Lee M, J Toxicol Environ Health B Crit Rev 2017; 20: 104-17. Morrison L. Arsenic contamination of drinking water in Ireland: a Vinyl chloride spatial analysis of occurrence and potential risk. Shumate AM, Taylor J, McFarland E, Tan C, Duncan MA. Sci Total Environ 2017; 579: 1863-75. Medical response to a vinyl chloride release from a train derailment: New Jersey, 2012. Vimercati L, Gatti MF, Gagliardi T, Cuccaro F, De Maria L, Disaster Med Public Health Prep 2017; online early: doi: Caputi A, Quarato M, Baldassarre A. 10.1017/dmp.2016.191: Environmental exposure to arsenic and chromium in an industrial area. Water Environ Sci Pollut Res Int 2017; online early: doi: 10.1007/s11356-017-8827-6: Suzuki H, Hasegawa I, Mishima S, Fukunaga T.

An autopsy case of fatal water intoxication with postmortem computed tomography findings of diluted Beryllium intestinal content and hemodilution. Boffetta P, Fordyce TA, Mandel JS. J Forensic Radiol Imaging 2016; 7: 43-6. A mortality study of beryllium workers. Cancer Med 2016; 5: 3596-605. White spirit Vanhoucke J, Buylaert W, Colpaert K, De Paepe P. Cadmium Ingestion of white spirit resulting in perineal skin burns: a Aliomrani M, Sahraian MA, Shirkhanloo H, Sharifzadeh M, case report and review of the literature. Khoshayand MR, Ghahremani MH. Acta Clin Belg 2017; online early: Blood concentrations of cadmium and lead in multiple doi: 10.1080/17843286.2017.1290190: sclerosis patients from Iran. Iran J Pharm Res 2016; 15: 825-33. METALS Lee W, Lee S, Roh J, Won J-U, Yoon J-H. General The association between involuntary smoking exposure Edem VF, Akintunde K, Adelaja YA, Nwozo SO, Charles- with urine cotinine level and blood cadmium level in Davies M. general non-smoking populations. Zinc, lead, and cadmium levels in serum and milk of J Korean Med Sci 2017; 32: 568-75. lactating women in Ibadan, Nigeria. Toxicol Ind Health 2017; 33: 28-35. Olmedo P, Grau-Perez M, Fretts A, Tellez-Plaza M, Gil F, Yeh F, Umans JG, Francesconi KA, Goessler W, Fan G, Zhou F, Feng C. Franceschini N, Lee ET, Best LG, Cole SA, Howard BV, Toxic effects of combined exposure to four heavy metals Navas-Acien A. at low doses. Dietary determinants of cadmium exposure in the Strong J Hazard Mater 2017; 323 Part B: 737-8. Heart Family Study. Food Chem Toxicol 2017; 100: 239-46. Lentini P, Zanoli L, Granata A, Signorelli SS, Castellino P,

Dell'Aquila R. Satarug S, Vesey DA, Gobe GC. Kidney and heavy metals - The role of environmental Health risk assessment of dietary cadmium intake: do exposure (review). current guidelines indicate how much is safe? Mol Med Rep 2017; online early: Environ Health Perspect 2017; 125: 284-8. doi: 10.3892/mmr.2017.6389:

López-Rodríguez G, Galván M, González-Unzaga M, Chromium Hernández Ávila J, Pérez-Labra M. Remy LL, Byers V, Clay T. Blood toxic metals and hemoglobin levels in Mexican Reproductive outcomes after non-occupational exposure children. to hexavalent chromium, Willits California, 1983–2014. Environ Monit Assess 2017; 189: 179. Environ Health 2017; 16: 18.

Pappalardo AM, Copat C, Ferrito V, Grasso A, Ferrante M. Vimercati L, Gatti MF, Gagliardi T, Cuccaro F, De Maria L, Heavy metal content and molecular species identification Caputi A, Quarato M, Baldassarre A. in canned tuna: insights into human food safety. Environmental exposure to arsenic and chromium in an Mol Med Rep 2017; online early: industrial area. doi: 10.3892/mmr.2017.6376: Environ Sci Pollut Res Int 2017; online early: doi: 10.1007/s11356-017-8827-6: Qayyum MA, Shah MH. Study of trace metal imbalances in the blood, scalp hair and nails of oral cancer patients from Pakistan. Iron Sci Total Environ 2017; 593-594: 191-201. Ramanathan G, Olynyk JK, Ferrari P. Diagnosing and preventing iron overload. Shao W, Liu Q, He X, Liu H, Gu A, Jiang Z. Hemodial Int 2017; online early: doi: 10.1111/hdi.12555: Association between level of urinary trace heavy metals and obesity among children aged 6-19 years: NHANES Rostoker G, Vaziri ND. 1999–2011. Impact of iatrogenic iron overload on the course of Environ Sci Pollut Res Int 2017; online early: doi: hepatitis C in dialysis population: a plea for caution. 10.1007/s11356-017-8803-1: Hemodial Int 2017; online early: doi: 10.1111/hdi.12557:

Lead Lithium Aliomrani M, Sahraian MA, Shirkhanloo H, Sharifzadeh M, Cervello S, Cancel A, Boutet C, Schneider F, Giraux P, Khoshayand MR, Ghahremani MH. Laurent B, Fakra E. Blood concentrations of cadmium and lead in multiple Atypical permanent neurological sequelae after an acute sclerosis patients from Iran. intoxication with lithium and aripiprazole. Iran J Pharm Res 2016; 15: 825-33. J Affect Disord 2017; 214: 97-9.

Burns KM, Shoag JM, Kahlon SS, Parsons PJ, Bijur PE, Hanak AS, Chevillard L, Lebeau R, Risède P, Laplanche JL, Taragin BH, Markowitz M. Benturquia N, Mégarbane B. Lead aprons are a lead exposure hazard. Neurobehavioral effects of lithium in the rat: investigation of J Am Coll Radiol 2016; online early: the effect/concentration relationships and the contribution doi: 10.1016/j.jacr.2016.10.024: of the poisoning pattern. Prog Neuropsychopharmacol Biol Psychiatry 2017; 76:

124-33. Dai Y, Huo X, Zhang Y, Yang T, Li M, Xu X.

Elevated lead levels and changes in blood morphology and Vodovar D, Mégarbane B. erythrocyte CR1 in preschool children from an e-waste Do not forget gastrointestinal decontamination in the early area. management of lithium poisoning. Sci Total Environ 2017; 592: 51-9. Basic Clin Pharmacol Toxicol 2017; online early: doi: 10.1111/bcpt.12758: De Almeida Lopes ACB, Silbergeld EK, Navas-Acien A, Zamoiski R, Martins AdC, Jr., Camargo AEI, Urbano MR, Zamani N, Paeezi M, Hassanian-Moghaddam H. Mesas AE, Paoliello MMB. Response to: Do not forget gastrointestinal decontamination Association between blood lead and blood pressure: a in the early management of lithium poisoning. population-based study in Brazilian adults. Basic Clin Pharmacol Toxicol 2017; online early: doi: Environ Health 2017; 16: 27. 10.1111/bcpt.12759:

Fenga C, Gangemi S, Alibrandi A, Costa C, Micali E. Manganese Relationship between lead exposure and mild cognitive Bjørklund G, Chartrand MS, Aaseth J. impairment. Manganese exposure and neurotoxic effects in children. J Prev Med Hyg 2016; 57: e205-e210. Environ Res 2017; 155: 380-4.

Fenga C, Gangemi S, Di Salvatore V, Falzone L, Libra M. Immunological effects of occupational exposure to lead Nickel (review). Haber LT, Bates HK, Allen BC, Vincent MJ, Oller AR. Mol Med Rep 2017; online early: Derivation of an oral toxicity reference value for nickel. Regul Toxicol Pharmacol 2017; online early: doi: doi: 10.3892/mmr.2017.6381: 10.1016/j.yrtph.2017.03.011:

Grasso IA, Blattner MR, Short T, Downs JW. Severe systemic lead toxicity resulting from extra-articular Polonium retained shrapnel presenting as jaundice and hepatitis: a Harrison J, Fell T, Leggett R, Lloyd D, Puncher M, case report and review of the literature. Youngman M. Mil Med 2017; 182: e1843-e1848. The polonium-210 poisoning of Mr Alexander Litvinenko. J Radiol Prot 2017; 37: 266-78. Holland MG, Cawthon D, Dreger M. Workplace lead exposure. PESTICIDES J Occup Environ Med 2016; 58: e371-e374. General

Chang C, Chen M, Gao J, Luo J, Wu K, Dong T, Zhou K, He Jurdziak M, Gac P, Poreba R, Gonerska M, Jonkisz A, X, Hu W, Wu W, Lu C, Hang B, Meeker JD, Wang X, Xia Y. Gromek M, Poreba M, Szymanska-Chabowska A, Mazur G, Current pesticide profiles in blood serum of adults in Sobieszczanska M. Jiangsu Province of China and a comparison with other Genetic variability in the system of natriuretic B peptide countries. and principal toxicological parameters in workers exposed Environ Int 2017; online early: to lead. doi: 10.1016/j.envint.2017.03.004: Environ Toxicol Pharmacol 2017; 49: 74-80.

Dutta S, Bahadur M. Ramji Z, Laflamme M. Cytogenetic analysis of micronuclei and cell death Ankle lead arthropathy and systemic lead toxicity secondary parameters in epithelial cells of pesticide exposed tea to a gunshot wound after 49 years: a case report. garden workers. J Foot Ankle Surg 2017; online early: Toxicol Mech Methods 2016; 26: 627-34. doi: 10.1053/j.jfas.2016.12.005: Gao X, Tan Y, Guo H. Tassiopoulos K, Huo Y, Braun J, Williams PL, Smith R, Simultaneous determination of amitraz, chlordimeform, Aschengrau A, Nichols S, Hazra R, Meyer WA, Knapp K, formetanate and their main metabolites in human urine by Deygoo NS, Seage GR, III. high performance liquid chromatography-tandem mass Blood lead levels and neurodevelopmental function in spectrometry. perinatally HIV-exposed, uninfected children in a US-based J Chromatogr B Biomed Sci Appl 2017; 1052: 27-33. longitudinal cohort study. AIDS Res Hum Retroviruses 2017; online early: doi: Knipe DW, Chang S-S, Dawson A, Eddleston M, Konradsen 10.1089/AID.2016.0265: F, Metcalfe C, Gunnell D.

Suicide prevention through means restriction: Impact of Kavousi-Gharbi S, Jalli R, Rasekhi-Kazerouni A, Habibagahi the 2008-2011 pesticide restrictions on suicide in Sri Z, Marashi SM. Lanka. Discernment scheme for paraquat poisoning: a five-year PLoS ONE 2017; 12: e0172893. experience in Shiraz, Iran. World J Exp Med 2017; 7: 31-9. Linke B, Mohr S, Ramsingh D, Bhuller Y. A retrospective analysis of the added value of 1-year dog Müller TE, Nunes ME, Menezes CC, Marins AT, studies in pesticide human health risk assessments. Leitemperger J, Gressler AC, Carvalho FB, de Freitas CM, Crit Rev Toxicol 2017; online early: Quadros VA, Fachinetto R, Rosemberg DB, Loro VL. doi: 10.1080/10408444.2017.1290044: Sodium selenite prevents paraquat-induced neurotoxicity in zebrafish. Mortimer K, Feary J. Mol Neurobiol 2017; online early: doi: 10.1007/s12035- Occupational exposure to pesticides: time to nip it in the bud? 017-0441-6: Thorax 2017; online early: doi: 10.1136/thoraxjnl-2016- 209686: Xu X, Yu Z, Liang Y, Gao H, Liu Y, Yu Y. Mumps caused by paraquat-induced poisoning: a case report. Rai S, Gullapalli MD, Srivastava A, Shaik H, Siddiqui MH, Exp Ther Med 2016; 13: 401-4. Mudiam MK. A rapid method for the quantitative determination of 34 pesticides in nonalcoholic carbonated beverages using Chlorantraniliprole liquid-liquid extraction coupled to dispersive solid-phase Mishra A, Chandiraseharan V, Jose N, Sudarsanam T. cleanup followed by gas chromatography with tandem Chlorantraniliprole: a novel insecticide poisoning in humans. mass spectrometry. Indian J Crit Care Med 2016; 20: 742-4. J AOAC Int 2017; online early: doi: 10.5740/jaoacint.17- 0064: Glyphosate Lee J-W, Choi Y-J, Park S, Gil H-W, Song H-Y, Hong S-Y. Rusiecki JA, Beane Freeman LE, Bonner MR, Alexander M, Serum S100 protein could predict altered consciousness in Chen L, Andreotti G, Barry KH, Moore LE, Byun H-M, glyphosate or glufosinate poisoning patients. Kamel F, Alavanja M, Hoppin JA, Baccarelli A. Clin Toxicol 2017; online early: High pesticide exposure events and DNA methylation doi: 10.1080/15563650.2017.1286013: among pesticide applicators in the agricultural health study. Environ Mol Mutagen 2017; 58: 19-29. Vandenberg LN, Blumberg B, Antoniou MN, Benbrook CM, Carroll L, Colborn T, Everett LG, Hansen M, Landrigan PJ, Aluminium phosphide Lanphear BP, Mesnage R, Vom Saal FS, Welshons WV, Bashardoust B, Farzaneh E, Habibzadeh A, Sadeghi MSS. Myers JP. Successful treatment of severe metabolic acidosis due to Is it time to reassess current safety standards for acute aluminum phosphide poisoning with peritoneal glyphosate-based herbicides? dialysis: a report of 2 cases. J Epidemiol Community Health 2017; online early: doi: Iran J Kidney Dis 2017; 11: 165-7. 10.1136/jech-2016-208463:

Yan H, Xiang P, Zhang S, Shen B, Shen M. Insecticides Diagnosis of aluminum phosphide poisoning using a new Subhedar A, Karunaker B, Surendar J. analytical approach: forensic application to a lethal Comprehensive study of suicidal deaths due to insecticidal intoxication. poisons in females. Int J Legal Med 2017; online early: doi: 10.1007/s00414- Indian J Forensic Med Toxicol 2017; 11: 10-2. 017-1562-1:

Atrazine Organochlorine pesticides Lerro CC, Beane Freeman LE, Portengen L, Kang D, Lee K, General Blair A, Lynch CF, Bakke B, De Roos AJ, Vermeulen RCH. Abou-Elwafa Abdallah M, Zaky AH, Covaci A. A longitudinal study of atrazine and 2,4-D exposure and Levels and profiles of organohalogenated contaminants in oxidative stress markers among iowa corn farmers. human blood from Egypt. Environ Mol Mutagen 2017; 58: 30-8. Chemosphere 2017; 176: 266-72.

Sun Y, Li Y-S, Li B, Ma K, Li B-X. 2-4D A study of the age-related effects of lactational atrazine Lerro CC, Beane Freeman LE, Portengen L, Kang D, Lee K, exposure. Blair A, Lynch CF, Bakke B, De Roos AJ, Vermeulen RCH. Reprod Toxicol 2017; 69: 230-41. A longitudinal study of atrazine and 2,4-D exposure and

oxidative stress markers among iowa corn farmers. Zhang X, Zhang C-H, Zheng J, Li L-X, Geng T-Q, Zhang Y. Environ Mol Mutagen 2017; 58: 30-8. Potential biomarkers for monitoring the toxicity of long- term exposure to atrazine in rat by metabonomic analysis. Xenobiotica 2017; online early: Organophosphorus insecticides doi: 10.1080/00498254.2017.1303221: General Ali SS, Karunakar B, Khan MT. Bipyridyl herbicides Histopathological study of hepatorenopulmonary changes Jian-Wei L, Xiu-Yun L, Ai-Jun D. in deaths due to organophosphorus poisoning. Effectiveness of heparin eye drops in paraquat-induced Indian J Forensic Med Toxicol 2017; 11: 96-100. ocular injury. Cutan Ocul Toxicol 2017; online early: Arcury TA, Laurienti PJ, Chen H, Howard TD, Barr DB, doi: 10.1080/15569527.2017.1303706: Mora DC, Summers P, Quandt SA.

Organophosphate pesticide urinary metabolites among Rodenticides latino immigrants: North Carolina farmworkers and non- farmworkers compared. Strychnine J Occup Environ Med 2016; 58: 1079-86. Kidiyoor Y, Rai S, Bakkannavar SM, Nayak VC, James RI, Saravu K. Bao H-X, Tong P-J, Li C-X, Du J, Chen B-Y, Huang Z-H, Rhabdomyolysis and strychnine poisoning: a case report. Wang Y. Res J Pharm Biol Chem Sci 2016; 7: 45-7. Efficacy of fresh packed red blood transfusion in organophosphate poisoning. Zinc phosphide Medicine (Baltimore) 2017; 96: e6375. Nekooghadam S, Haghighatkhah H, Vaezi F, Sanei Taheri M, Moharamzad Y. De Lima Teixeira I, Bazan SGZ, Schelp AO, Luvizutto GJ, Zinc phosphide poisoning with unusual radiologic findings. De Lima FD, Bazan R. Clin Case Rep 2017; 5: 264-7. Abnormal spontaneous eye movements as initial presentation of organophosphate poisoning. Trakulsrichai S, Kosanyawat N, Atiksawedparit P, Sriapha C, Tremor Other Hyperkinet Mov (N Y) 2017; 7: 445. Tongpoo A, Udomsubpayakul U, Rittilert P, Wananukul W. Clinical characteristics of zinc phosphide poisoning in Munta K, Santosh P, Surath MR. Thailand. Severe hypothermia causing ventricular arrhythmia in Ther Clin Risk Manag 2017; 13: 335-40. organophosphorus poisoning. Indian J Crit Care Med 2017; 21: 99-101. CHEMICAL WARFARE, Muñoz-Quezada MT, Lucero B, Iglesias V, Levy K, Muñoz BIOLOGICAL WARFARE AND MP, Achú E, Cornejo C, Concha C, Brito AM, Villalobos M. Exposure to organophosphate (OP) pesticides and health RIOT CONTROL AGENTS conditions in agricultural and non-agricultural workers Chemical warfare from Maule, Chile. General Int J Environ Health Res 2017; 27: 82-93. Be'eri E, Owen S, Shachar M, Barlavie Y, Eisenkraft A.

Impact of adding a filter for protection from toxic Priyendu A, Vandana KE, Nilima R, Varma M, Prabhu N, inhalational compounds to the ventilation circuit of Rahim AA, Nagappa AN. mechanically ventilated patients. Antibiotic prophylaxis in organophosphorus poisoning: a Disaster Mil Med 2016; 2: 3. study of health and economic outcomes.

Saudi Pharm J 2017; 25: 332-6. Mustard gas Ravikanth R. Liu C-C, Liu S-L, Xi H-L, Yu H-L, Zhou S-K, Huang G-L, Role of magnetic resonance imaging in diagnosing Liang L-H, Liu J-Q. neurological complications in intermediate syndrome of Simultaneous quantification of four metabolites of sulfur organophosphate poisoning. mustard in urine samples by ultra-high performance liquid Indian J Crit Care Med 2017; 21: 105-7. chromatography-tandem mass spectrometry after solid phase extraction. Zhao A, Chen A, Guan Q, Shi J. J Chromatogr A 2017; 1492: 41-8. Effect of hemoperfusion on acute injury induced by acute organic phosphorus pesticide poisoning. Mousavi B, Khateri S, Soroush M, Ganjparvar Z. Int J Clin Exp Med 2016; 9: 23440-6. Sulfur mustard exposure and mental health in survivors of Iran–Iraq war with severe lung injuries. Chlorpyrifos Toxin Rev 2017; online early: doi: 10.1080/15569543.2017.1303779: Rathod AL, Garg RK.

Chlorpyrifos poisoning and its implications in human fatal Nourani MR, Mahmoodzadeh Hosseini H, Azimzadeh cases: a forensic perspective with reference to Indian Jamalkandi S, Imani Fooladi AA. scenario. Cellular and molecular mechanisms of acute exposure to J Forensic Leg Med 2017; 47: 29-34. sulfur mustard: a systematic review. J Recept Signal Transduct Res 2017; 37: 200-16. Diisopropylfluorophosphate Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Shoeibi N, Mousavi MN, Balali-Mood M, Moshiri M, Garbow JR, Lein PJ. Darchini-Maragheh E, Mousavi SR, Abrishami M. Magnetic resonance imaging reveals progressive brain injury Long-term complications of sulfur mustard poisoning: in rats acutely intoxicated with diisopropylfluorophosphate. retinal electrophysiological assessment in 40 severely Toxicol Sci 2017; online early: intoxicated Iranian veterans. doi: 10.1093/toxsci/kfx049: Int J Retina Vitreous 2017; 3: 7.

Pyrethroid insecticides Nerve agents General VX Hisada A, Yoshinaga J, Zhang J, Kato T, Shiraishi H, Carmany D, Walz AJ, Hsu F-L, Benton B, Burnett D, Shimodaira K, Okai T, Ariki N, Komine Y, Shirakawa M, Gibbons J, Noort D, Glaros T, Sekowski JW. Noda Y, Kato N. Activity based protein profiling leads to identification of Maternal exposure to pyrethroid insecticides during novel protein targets for nerve agent VX. pregnancy and infant development at 18 months of age. Chem Res Toxicol 2017; online early: Int J Environ Res Public Health 2017; 14: 52. doi: 10.1021/acs.chemrestox.6b00438:

Clinical and laboratory parameters associated with acute PLANTS kidney injury in patients with snakebite envenomation: a Abrus precatorius (Jequirity) prospective observational study from Myanmar. Sant B, Lakshmana Rao PV, Nagar DP, Pant SC, Bhasker ASB. BMC Nephrol 2017; 18: 92. Evaluation of abrin induced nephrotoxicity by using novel renal injury markers. Bawaskar HS, Bawaskar PH, Bawaskar PH. Toxicon 2017; 131: 20-8. Pathophysiology of dilatation of pupils due to scorpion and snake envenomation and its therapeutic value: clinical Mushrooms observations. Dadpour B, Tajoddini S, Rajabi M, Afshari R. Indian J Ophthalmol 2017; 65: 67-70. Mushroom poisoning in the northeast of Iran; a retrospective 6-year epidemiologic study. Chauhan V, Thakur S. Emergency 2017; 5: e23. The North-South divide in snake bite envenomation in India. J Emerg Trauma Shock 2016; 9: 151-4. Grama A, Bizo A, Delean D, Aldea C, Stefanescu A, Pop TL. Treatment of acute liver failure caused by mushroom Das S, Barnwal P, Maiti T, Ramasamy A, Mondal S, Babu D. poisoning in children. Addiction to snake venom. Eur J Pediatr 2016; 175: 1738. Subst Use Misuse 2017; online early: doi: 10.1080/10826084.2016.1272614: Toxicodendron spp. (Poison ivy) Signore RJ. Thakur R, Mukherjee AK. Prevention of poison ivy dermatitis with oral homeopathic Pathophysiological significance and therapeutic applications Rhus toxicodendron. of snake venom protease inhibitors. Dermatol Online J 2017; 23: 17. Toxicon 2017; 131: 37-47.

Slaughter RJ, Beasley MG, Schep LJ. Welton R, Liew D, Braitberg G. Dermatitis due to Toxicodendron plants: a common Incidence of fatal snake bite in Australia: A coronial based occurrence during autumn. retrospective study (2000–2016). N Z Med J 2017; 130: 82-3. Toxicon 2017; 131: 11-5.

ANIMALS Colubridae Bee stings Torres-Bonilla KA, Floriano RS, Schezaro-Ramos R, Barbosa AN, Boyer L, Chippaux J-P, Medolago NB, Rodrigues-Simioni L, da Cruz-Höfling MA. Caramori CA, Paixão AG, Poli JPV, Mendes MB, Dos Santos A survey on some biochemical and pharmacological LD, Ferreira RS, Jr., Barraviera B. activities of venom from two Colombian colubrid snakes, A clinical trial protocol to treat massive Africanized Erythrolamprus bizona (Double-banded coral snake mimic) honeybee (Apis mellifera) attack with a new apilic and Pseudoboa neuwiedii (Neuwied's false boa). antivenom. Toxicon 2017; 131: 29-36. J Venom Anim Toxins Incl Trop Dis 2017; 23: 14. Crotalinae (Pit vipers) Fish/marine poisoning Bailey AM, Justice S, Davis GA, Weant K. Delayed hematologic toxicity following rattlesnake en- Ciguatera venomation unresponsive to crotalidae polyvalent Friedman MA, Fernandez M, Backer LC, Dickey RW, Bernstein antivenom. J, Schrank K, Kibler S, Stephan W, Gribble MO, Bienfang P, Am J Emerg Med 2017; online early: Bowen RE, Degrasse S, Flores Quintana HA, Loeffler CR, doi: 10.1016/j.ajem.2017.02.045: Weisman R, Blythe D, Berdalet E, Ayyar R, Clarkson-

Townsend D, Swajian K, Benner R, Brewer T, Fleming LE. Chien C-Y, Liao S-C, Liao C-H, Huang T-S, Chen Y-H. An updated review of ciguatera fish poisoning: clinical, epidemiological, environmental, and public health Envenoming by Viridovipera stejnegeri snake: a patient with management. liver cirrhosis presenting disruption of hemostatic balance. Mar Drugs 2017; 15: 72. J Venom Anim Toxins Incl Trop Dis 2017; 23: 10.

Quail Quan D, Zurcher K. Reversible atrial fibrillation following Crotalinae envenomation. Dogan I, Eser B, Seker A. J Venom Anim Toxins Incl Trop Dis 2017; 23: 16. Rare cause of acute kidney injury associated with rhabdomyolysis: quail meat consumption. Santos Barreto GNL, de Oliveira SS, Dos Anjos IV, Ther Apher Dial 2016; 20: 690-1. Chalkidis HdM, Mourão RHV, da Silva AMM, Sano-Martins

IS, Gonçalves LRdC. Scorpions Experimental Bothrops atrox envenomation: efficacy of Bawaskar HS, Bawaskar PH, Bawaskar PH. antivenom therapy and the combination of Bothrops Pathophysiology of dilatation of pupils due to scorpion and antivenom with dexamethasone. snake envenomation and its therapeutic value: clinical PLoS Negl Trop Dis 2017; 11: e0005458. observations. Indian J Ophthalmol 2017; 65: 67-70. Schezaro-Ramos R, Collaço RCdO, Randazzo-Moura P, Rocha T, Cogo JC, Rodrigues-Simioni L. Snake bites Influence of phospholipasic inhibition on neuromuscular Aye K-P, Thanachartwet V, Soe C, Desakorn V, Thwin K-T, activity of Bothrops fonsecai snake venom. Chamnanchanunt S, Sahassananda D, Supaporn T, Sitprija V. Toxicon 2017; 130: 35-43.

Viperinae (True vipers) Toxicity of the venom of Latrodectus (Araneae: Theridiidae) Lamb T, de Haro L, Lonati D, Brvar M, Eddleston M. spiders from different regions of Argentina and Antivenom for European Vipera species envenoming. neutralization by therapeutic antivenoms. Clin Toxicol 2017; online early: Toxicon 2017; 130: 63-72. doi: 10.1080/15563650.2017.1300261: Wasps Spiders Tao X, Huang L, Fang C, Liu C, Qing L, Cai H. de Roodt AR, Lanari LC, Laskowicz RD, De Oliveira VC, Irazu Ischemic stroke due to wasp sting: a case report. LE, González A, Giambelluca L, Nicolai N, Barragán JH, Clin Toxicol 2017; online early: Ramallo L, López RA, Lopardo J, Jensen O, Larrieu E, doi: 10.1080/15563650.2017.1306072: Calabró A, Vurcharchuc MG, Lago NR, García SI, de Titto EH, Damín CF.

INDEX

2-4D ...... 40 Carcinogenicity ...... 11 Abrin ...... 33 Cardiotoxicity ...... 11 Abrus precatorius ...... 42 Carfentanil ...... 31 Acetaminophen ...... 31 Chemical incidents ...... 33 Acetylcysteine ...... 22 Chemical warfare, general ...... 41 Acrylic adhesives ...... 33 Chemicals, general ...... 33 Activated charcoal ...... 22 Chloral hydrate ...... 32 Air pollution ...... 33 Chlorantraniliprole ...... 40 Alcohol ...... 33 Chloroprocaine ...... 25 Alkyl nitrites ...... 24 Chlorpyrifos ...... 41 Aluminium phosphide ...... 40 Chromium ...... 38 Amfetamines ...... 24 Ciguatera ...... 42 Anaesthetics ...... 25 Clomiphene citrate...... 27 Analytical toxicology ...... 10 Clozapine ...... 26 Animals, general ...... 42 Cocaine...... 27 Antiarrhythmic drugs ...... 25 Codeine ...... 31 Antibiotics ...... 25 Colubridae ...... 42 Anticoagulants ...... 25 Corrosives ...... 34 Anticonvulsants ...... 25 Cosmetics ...... 34 Antidepressants ...... 26 Crotalinae ...... 42 Antidotes ...... 22 Cyanide ...... 34 Antihistamines ...... 26 Cyclobenzaprine ...... 28 Antineoplastic drugs ...... 26 Dabigatran ...... 25 Antipsychotics ...... 26 Dermal toxicity ...... 11 Antitussives ...... 27 Designer benzodiazepines ...... 29 Antivenom ...... 22 Designer opioids ...... 29 Antiviral drugs ...... 27 Desomorphine ...... 28 Apixaban ...... 25 Developmental toxicology ...... 12 Aripiprazole ...... 26 Diacetylmorphine...... 28 Arsenic ...... 38 Diesel ...... 37 Asbestos...... 34 Dietary supplements ...... 28 Atazanavir ...... 27 Difluoroethane ...... 34 Atrazine ...... 40 Diisopropylfluorophosphate ...... 41 Baclofen ...... 27 Dioxins ...... 34 Batteries ...... 34 Diphenhydramine ...... 26 Bee stings ...... 42 DMSA ...... 22 Benzene ...... 37 Driving under the influence ...... 12 Benzodiazepines ...... 27 Drugs, general ...... 23 Benzonatate ...... 27 E-cigarettes and e-liquids ...... 34 Beryllium ...... 38 Ecstasy ...... 24 Betamethasone ...... 32 Endocrine disrupting chemicals ...... 35 Biological warfare...... 41 Endotoxin ...... 35 Biomarkers ...... 11 Epidemiology...... 12 Bipyridyl herbicides ...... 40 Esomeprazole ...... 31 Botulinum toxin ...... 34 Ethanol ...... 33 Brimonidine ...... 27 Ethnic remedies ...... 28 Bromobenzene ...... 37 Ethylene glycol ...... 35 Buprenorphine ...... 31 Etomidate ...... 23 Bupropion ...... 26 Extracorporeal membrane oxygenation ...... 23 Cadmium ...... 38 Extracorporeal treatments ...... 23 Caffeine...... 27 Fentanyl...... 31 Cannabis ...... 27 Fish/marine poisoning ...... 42 Capecitabine ...... 26 Flame retardants ...... 35 Carbon dioxide ...... 34 Flecainide...... 25 Carbon monoxide ...... 34 Fluoride ...... 35

Fluoropolymers ...... 35 Organochlorine pesticides, general ...... 40 Folic acid ...... 33 Organophosphorus insecticides, general ...... 40 Forensic toxicology ...... 14 Oxcarbazepine ...... 26 Fragrance chemicals ...... 35 Oxybutynin ...... 23 Gabapentin ...... 25 Paediatric toxicology ...... 18 Gamma hydroxybutyrate ...... 28 Paracetamol ...... 31 Gasoline ...... 36 Perfluorinated compounds ...... 36 Gastrointestinal decontamination ...... 23 Peritoneal dialysis ...... 23 Genotoxicity ...... 15 Pesticides, general ...... 39 Glyphosate ...... 40 Petrol...... 36 Haemodialysis ...... 23 Phenethylamines ...... 29 Haemoperfusion...... 23 Phthalates ...... 37 Hazardous waste ...... 33 Pit vipers ...... 42 Helium ...... 36 Plants, general ...... 42 Heparin ...... 23 Poison information centres ...... 19 Hepatotoxicity ...... 15 Poison ivy ...... 42 Herbal medicines ...... 28 Poisons information ...... 19 Heroin ...... 28 Pollution ...... 33 Hydroxocobalamin ...... 22 Polonium...... 39 Hydroxychloroquine ...... 28 Polybrominated diphenyl ethers ...... 37 Ibuprofen ...... 30 Polychlorinated biphenyls ...... 37 Idarucizumab ...... 22 Polymorphisms ...... 20 Inhalation toxicity ...... 15 Pregabalin ...... 26 Insecticides ...... 40 Proton pump inhibitors...... 31 Iron ...... 38 Psychiatric aspects ...... 20 Isosorbide dinitrate ...... 22 Psychotropic drugs ...... 31 Jequirity ...... 42 Pyrethroid insecticides, general ...... 41 Kinetics ...... 16 Quail...... 42 Krokodil ...... 28 Quetiapine ...... 26 Lead...... 39 Radiation ...... 37 Levamisole ...... 28 Reprotoxicity ...... 20 Levetiracetam ...... 25 Risk assessment ...... 20 Lipid emulsion therapy ...... 22 Rivastigmine ...... 32 Lithium ...... 28, 39 Rodenticides ...... 41 Loperamide ...... 28 Salicylates ...... 32 Management, general ...... 21 Scorpions ...... 42 Manganese ...... 39 Sedatives ...... 32 Marijuana ...... 27 Smoke ...... 37 MDMA ...... 24 Snake bites ...... 42 Mechanisms ...... 16 Sodium nitrite ...... 37 Medication errors ...... 16 Spiders ...... 43 Melphalan ...... 26 SSRIs and SNRIs ...... 32 Metabolism ...... 16 Steroids ...... 32 Metals, general ...... 38 Strychnine ...... 41 Methadone ...... 31 Substance abuse ...... 32 Methanol ...... 36 Suicide ...... 21 Methotrexate ...... 26 Synthetic cannabinoids ...... 29 Methylphenidate ...... 28 Synthetic cathinones ...... 30 Muscle relaxants ...... 28 Tattoo inks ...... 37 Mushrooms ...... 42 Teicoplanin ...... 25 Mustard gas ...... 41 Tobacco ...... 37 Nalmefene ...... 29 Toluene ...... 37 Naloxone ...... 22 Topiramate ...... 26 Naltrexone ...... 29 Toxicodendron spp ...... 42 Naphthalene ...... 36 Toxicology, general ...... 10 Nephrotoxicity ...... 16 Triclosan ...... 38 Nerve agents ...... 41 True vipers...... 43 Neurotoxicity ...... 16 Tryptamines ...... 30 Nickel ...... 39 Vinyl chloride ...... 38 Nicotine ...... 29 Viperinae ...... 43 Nitrous oxide ...... 36 Vitamins...... 33 Novel psychoactive substances ...... 29 Warfarin ...... 25 NSAIDs ...... 30 Wasps ...... 43 Occupational toxicology ...... 17 Water ...... 38 Ocular toxicity ...... 17 Water pollution ...... 33 Opioid maintenance therapy ...... 23 White spirit ...... 38 Opioids ...... 30 Zinc phosphide ...... 41

The NPIS is commissioned by Public Health England