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viruses Novel Concepts in Virology 2020 5–7 FEBRUARY 2020 | BARCELONA, SPAIN Program Booklet Organizer Sponsors viruses Media Partners International Journal of Molecular Sciences reports biomedicines Partnering Societies WIFI: Auditori.axa PASSWORD: auditori96 Viruses 2020—Novel Concepts in Virology AXA Convention Centre Barcelona, Spain 5–7 February 2020 MDPI • Basel • Beijing • Wuhan • Barcelona • Belgrade Organizing Committees Conference Chairs Dr. Eric O. Freed Dr. Albert Bosch Scientific Committee Dr. Graham F. Hatfull Dr. Michelle Flenniken Prof. Dr. K. Andrew White Dr. Susan Weiss Prof. Dr. Diane Griffin Organised by Conference Secretariat Dr. Sara Martinez Mr. Aimar Xiong Ms. Penny Zhang Email: [email protected] Welcome from the Chairs Dear Colleagues, It is with great pleasure that we announce the conference Viruses 2020—Novel Concepts in Virology to be held in Barcelona, Spain, 5‐7 February 2020. Because of their global impact on human, animal, and plant health and their utility as tractable model systems, viruses continue to play a central role in all aspects of biomedical research, ranging from molecular and cell biology, structural biology, and immunology to evolution, epidemiology, and bioinformatics. This conference will bring together leading virologists from around the world and across the broad field of virology to share results of their recent studies. Meeting participants will have the opportunity to present posters and short talks on their work and discuss their research in a stimulating and collegial environment. The conference is sponsored by MDPI, the publisher of the open‐access journal Viruses and follows the very successful meetings Viruses 2016—At the Forefront of Virus‐Host Interactions held in January 2016 in Basel, Switzerland and Viruses 2018—Breakthroughs in Viral Replication, held in February 2018 in Barcelona. We very much look forward to seeing you at this exciting meeting in Barcelona. Dr. Eric O. Freed Dr. Albert Bosch Conference Chair Conference Chair Table of Contents General Information 1 Invited Speakers 8 Program at a Glance 10 Conference Program 11 Poster Lists 17 Abstracts—Session 1 25 General Topics in Virology Abstracts—Session 2 41 Structural Virology Abstract—Session 3 49 Antiviral Innate Immunity Abstract—Session 4 63 Viral Pathogenesis Abstract—Session 5 77 Mechanisms of Virus Replication Abstract—Session 6 89 Viral Genetics and Evolution Abstracts—Poster Exhibition 101 General Information Viruses (ISSN 1999–4915; CODEN: VIRUBR) is a peer‐reviewed open access journal of virology, published monthly online by MDPI. The American Society for Virology (ASV), the Spanish Society for Virology (SEV), the Canadian Society for Virology (CSV), the Italian Society for Virology (SIV‐ISV), the Australasian Virology Society (AVS) and more societies are affiliated with Viruses and their members receive a discount on the article processing charges. Among other databases, Viruses is indexed by the Science Citation Index Expanded (Web of Science), MEDLINE (PubMed) and other databases. Full‐text available in PubMed Central. Journal Webpage: https://www.mdpi.com/journal/viruses Impact factor: 3.811 (2018) 5‐Year Impact Factor: 3.916 (2018) Viruses 2020—Novel Concepts in Virology 2 Conference Venue Auditorium AXA of the AXA Convention Centre Avinguda Diagonal, 547, 08029 Barcelona, Spain Registration Desk The desk for registration, information and distribution of documents will be open from 08:00 on 5 February 2020. Certificate of Attendance Upon request, the participants of the event will receive an electronic Certificate of Attendance by email once the event is concluded. Disclaimer Delegates will receive a name‐badge at the Information Desk, upon registration. The badge must be worn prominently in order to gain access to the congress area during all scientific and social events. Admission will be refused to anyone not in possession of an appropriate badge. Insurance The organizers do not accept liability for personal accident, loss, or damage to private property incurred as a result of participation in the Viruses 2020—Novels Concepts in Virology. Delegates are advised to arrange appropriate insurance to cover travel, cancellation costs, medical, and theft or damage of belongings. Emergency Information All emergencies in Spain: 112 (no area code needed) Ambulance (Ambulancia) and health emergencies: 061 or 112 Fire brigade (Cuerpo de bomberos): 080 or 112 Spanish National Police (Policía nacional): 091 Viruses 2020—Novel Concepts in Virology 3 Barcelona Barcelona is the capital and largest city of Catalonia and is Spain’s second largest city, with a population of over one and half million people. Located on the northeastern Mediterranean coast of Spain, this city has a rich and diverse history, with its roots dating back to Roman times. The fruitful medieval period established Barcelona’s position as the economic and political centre of the Western Mediterranean. The city’s Gothic Quarter bears witness to the splendour enjoyed by the city from the 13th to the 15th centuries. The 20th century ushered in widespread urban renewal throughout Barcelona city, culminating in its landmark Eixample district, which showcases some of Barcelona’s most distinctive Catalan art‐nouveau, or modernista, buildings. The Catalan Antoni Gaudí, one of the most eminent architects, designed buildings such as La Pedrera, the Casa Batlló and the Sagrada Família church, which have become world‐famous landmarks. In 1992, Barcelona gained international recognition by hosting the Olympic games which brought about a massive upturn in its tourism industry. For visitors, this has translated into the very modern, yet incredibly old city you see now in the 21st century, where new elements work to both preserve and celebrate both the city’s heritage and origins. Barcelona is plenty of outdoor markets, restaurants, shops, museums, and churches. The city is also very walkable, with an extensive and reliable Metro system for more far‐flung destinations. For a complete overview, see wikitravel.org or visit barcelonaturisme.com. Viruses 2020—Novel Concepts in Virology 4 The AXA Convention Centre The event will be held at the Auditorium AXA of the AXA Convention Centre, which is part of an enormous complex located on the main artery of Barcelona that integrates a shopping centre, two hotels, 48.000 m² of offices, a parking lot, two schools, a sport centre and a public park. City communications are excellent and access from Barcelona’s Airport and Sants Station is very quick. The avant‐garde design and construction quality emerge from each and every detail of the building, turning the l’ILLA complex into an emblematic reference of the city. AXA Convention Centre (Source: www.axa.es) As a whole, it is more than an auditorium: it is an infrastructure designed to offer quality, flexibility and integral attention through its wide range of services. How to Reach the Venue Address: Avinguda Diagonal, 547, 08029 Barcelona, Spain. Venue Location (Source: www.axa.es) Viruses 2020—Novel Concepts in Virology 5 Conference Dinner Thursday 6th February, 20:30 Price: 50€ Sold Out. To join the waiting list please ask at the Information Desk. The conference dinner will be held at La Camarga, a cutting‐edge restaurant specialized in Mediterranean cuisine with deep gastronomic roots that inspires dishes full of contemporary flavours and textures La Camarga is located at Carrer d’Aribau, 117, only a few minutes away from Passeig de Gràcia, one of the major avenues in Barcelona and one of its most important shopping and business areas, containing several of the city’s most celebrated pieces of architecture (such as La Pedrera or Casa Batlló).You can easily reach the restaurant either by taxi, bus or Metro. If you were to choose the second option, the closest metro stations are”Hospital Clinic” on Line 5 (blue), or”Diagonal” on Line 3 (green). Viruses 2020—Novel Concepts in Virology 6 Program Keynote Speakers Prof. Peter Palese Department of Microbiology Icahn School of Medicine at Mount Sinai, New York, NY, USA Invited Speakers Dr. Michelle Flenniken Dr. Cristina Risco Dr. Susan Weiss Montana State University, National Center for University of Pennsylvania, Bozeman, MT, USA Biotechnology, Philadelphia, PA, USA Madrid, Spain Prof. Rotem Sorek Prof. Diane E. Griffin Dr. Stacy M. Horner Weizmann Institute of Science, Johns Hopkins Bloomberg Duke University Medical Rehovot, Israel School of Public Health, Center, Durham, NC, USA Baltimore, MD, USA Viruses 2020—Novel Concepts in Virology 8 Dr. Graham F. Hatfull Prof. K. Andrew White Dr. Stanley M. Lemon University of Pittsburgh, York University, The University of North Pittsburgh, PA, USA Toronto, ON, Canada Carolina at Chapel Hill, Chapel Hill, NC, USA Dr. Marco Vignuzzi Prof. Martin Beer Dr. Jason McLellan Institut Pasteur, Institute of Diagnostic The University of Texas Paris, France Virology (IVD), at Austin, Greifswald, Insel Riems, Austin, TX, USA Germany Prof. Rosa M. Pintó University of Barcelona, Barcelona, Spain Viruses 2020—Novel Concepts in Virology 9 Program at a Glance Viruses 2020–Novel Concepts in Virology 5–7 February 2020, Barcelona, Spain Wednesday 5 February 2020 Thursday 6 February 2020 Friday 7 February 2020 Check‐in Opening Ceremony Session 3. Antiviral Innate Session 5. Mechanisms of Session 1. General Topics in Immunity Virus Replication Virology Morning Coffee Break Coffee Break Coffee Break (Conference Group Photo) Session 1. Part II Session 3. Part II Session 5. Part II Lunch
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  • A Prenylated Dsrna Sensor Protects Against Severe COVID-19 and Is Absent in Horseshoe Bats

    A Prenylated Dsrna Sensor Protects Against Severe COVID-19 and Is Absent in Horseshoe Bats

    medRxiv preprint doi: https://doi.org/10.1101/2021.05.05.21256681; this version posted May 9, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license . @WilsonlabCVR Wickenhagen et al., A Prenylated dsRNA Sensor Protects Against Severe COVID-19 and is ABsent in Horseshoe Bats A Prenylated dsRNA Sensor Protects on global health, culture and prosperity. SARS-CoV-2 is Against Severe COVID-19 and is Absent in particularly sensitive to inhibition by type I interferons (IFNs) and there is great interest in understanding how individual Horseshoe Bats IFN-stimulated genes (ISGs) inhibit SARS-CoV-2, as type I IFNs play a major role in governing COVID-19 disease Arthur Wickenhagen1, Elena Sugrue1*, Spyros Lytras1*, 1* 1 1 outcome. Specifically, inborn errors (Zhang et al., 2020) Srikeerthana Kuchi , Matthew L Turnbull , Colin Loney , and single nucleotide polymorphisms (Pairo-Castineira et 1 1 1 Vanessa Herder , Jay Allan , Innes Jarmson , Natalia al., 2020) within the IFN system are linked with more severe 1 1 1 Cameron-Ruiz , Margus Varjak , Rute M Pinto , Douglas G COVID-19. Moreover, neutralizing anti-IFN autoantibodies 1 1 1 Stewart , Simon Swingler , Marko Noerenberg , Edward J likely prevent host IFN responses from controlling SARS- 2 2 1 D Greenwood , Thomas W M Crozier , Quan Gu , Sara CoV-2 replication, again resulting in severe COVID-19 3 3 4 Clohisey , Bo Wang , Fabio Trindade Maranhão Costa , disease (Bastard et al., 2020).