Practical Dermatology Methodical Recommendations
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A Diagnostic Approach to Pruritus
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by DigitalCommons@University of Nebraska University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln U.S. Air Force Research U.S. Department of Defense 2011 A Diagnostic Approach to Pruritus Brian V. Reamy Christopher W. Bunt Stacy Fletcher Follow this and additional works at: https://digitalcommons.unl.edu/usafresearch This Article is brought to you for free and open access by the U.S. Department of Defense at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in U.S. Air Force Research by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. A Diagnostic Approach to Pruritus BRIAN V. REAMY, MD, Uniformed Services University of the Health Sciences, Bethesda, Maryland CHRISTOPHER W. BUNT, MAJ, USAF, MC, and STACY FLETCHER, CAPT, USAF, MC Ehrling Bergquist Family Medicine Residency Program, Offutt Air Force Base, Nebraska, and the University of Nebraska Medical Center, Omaha, Nebraska Pruritus can be a symptom of a distinct dermatologic condition or of an occult underlying systemic disease. Of the patients referred to a dermatologist for generalized pruritus with no apparent primary cutaneous cause, 14 to 24 percent have a systemic etiology. In the absence of a primary skin lesion, the review of systems should include evaluation for thyroid disorders, lymphoma, kidney and liver diseases, and diabetes mellitus. Findings suggestive of less seri- ous etiologies include younger age, localized symptoms, acute onset, involvement limited to exposed areas, and a clear association with a sick contact or recent travel. Chronic or general- ized pruritus, older age, and abnormal physical findings should increase concern for underly- ing systemic conditions. -
Pediatric and Adolescent Dermatology
Pediatric and adolescent dermatology Management and referral guidelines ICD-10 guide • Acne: L70.0 acne vulgaris; L70.1 acne conglobata; • Molluscum contagiosum: B08.1 L70.4 infantile acne; L70.5 acne excoriae; L70.8 • Nevi (moles): Start with D22 and rest depends other acne; or L70.9 acne unspecified on site • Alopecia areata: L63 alopecia; L63.0 alopecia • Onychomycosis (nail fungus): B35.1 (capitis) totalis; L63.1 alopecia universalis; L63.8 other alopecia areata; or L63.9 alopecia areata • Psoriasis: L40.0 plaque; L40.1 generalized unspecified pustular psoriasis; L40.3 palmoplantar pustulosis; L40.4 guttate; L40.54 psoriatic juvenile • Atopic dermatitis (eczema): L20.82 flexural; arthropathy; L40.8 other psoriasis; or L40.9 L20.83 infantile; L20.89 other atopic dermatitis; or psoriasis unspecified L20.9 atopic dermatitis unspecified • Scabies: B86 • Hemangioma of infancy: D18 hemangioma and lymphangioma any site; D18.0 hemangioma; • Seborrheic dermatitis: L21.0 capitis; L21.1 infantile; D18.00 hemangioma unspecified site; D18.01 L21.8 other seborrheic dermatitis; or L21.9 hemangioma of skin and subcutaneous tissue; seborrheic dermatitis unspecified D18.02 hemangioma of intracranial structures; • Tinea capitis: B35.0 D18.03 hemangioma of intraabdominal structures; or D18.09 hemangioma of other sites • Tinea versicolor: B36.0 • Hyperhidrosis: R61 generalized hyperhidrosis; • Vitiligo: L80 L74.5 focal hyperhidrosis; L74.51 primary focal • Warts: B07.0 verruca plantaris; B07.8 verruca hyperhidrosis, rest depends on site; L74.52 vulgaris (common warts); B07.9 viral wart secondary focal hyperhidrosis unspecified; or A63.0 anogenital warts • Keratosis pilaris: L85.8 other specified epidermal thickening 1 Acne Treatment basics • Tretinoin 0.025% or 0.05% cream • Education: Medications often take weeks to work AND and the patient’s skin may get “worse” (dry and red) • Clindamycin-benzoyl peroxide 1%-5% gel in the before it gets better. -
WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/05 (2006.01) A61P 31/02 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/CA20 14/000 174 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 4 March 2014 (04.03.2014) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 13/790,91 1 8 March 2013 (08.03.2013) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: LABORATOIRE M2 [CA/CA]; 4005-A, rue kind of regional protection available): ARIPO (BW, GH, de la Garlock, Sherbrooke, Quebec J1L 1W9 (CA). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventors: LEMIRE, Gaetan; 6505, rue de la fougere, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Sherbrooke, Quebec JIN 3W3 (CA). -
Photodermatoses Update Knowledge and Treatment of Photodermatoses Discuss Vitamin D Levels in Photodermatoses
Ashley Feneran, DO Jenifer Lloyd, DO University Hospitals Regional Hospitals AMERICAN OSTEOPATHIC COLLEGE OF DERMATOLOGY Objectives Review key points of several photodermatoses Update knowledge and treatment of photodermatoses Discuss vitamin D levels in photodermatoses Types of photodermatoses Immunologically mediated disorders Defective DNA repair disorders Photoaggravated dermatoses Chemical- and drug-induced photosensitivity Types of photodermatoses Immunologically mediated disorders Polymorphous light eruption Actinic prurigo Hydroa vacciniforme Chronic actinic dermatitis Solar urticaria Polymorphous light eruption (PMLE) Most common form of idiopathic photodermatitis Possibly due to delayed-type hypersensitivity reaction to an endogenous cutaneous photo- induced antigen Presents within minutes to hours of UV exposure and lasts several days Pathology Superficial and deep lymphocytic infiltrate Marked papillary dermal edema PMLE Treatment Topical or oral corticosteroids High SPF Restriction of UV exposure Hardening – natural, NBUVB, PUVA Antimalarial PMLE updates Study suggests topical vitamin D analogue used prophylactically may provide therapeutic benefit in PMLE Gruber-Wackernagel A, Bambach FJ, Legat A, et al. Br J Dermatol, 2011. PMLE updates Study seeks to further elucidate the pathogenesis of PMLE Found a decrease in Langerhans cells and an increase in mast cell density in lesional skin Wolf P, Gruber-Wackernagel A, Bambach I, et al. Exp Dermatol, 2014. Actinic prurigo Similar to PMLE Common in native -
Patch Testing in Adverse Drug Reactions Has Not Always Been Appreciated, but There Is Growing a Interest in This Field
24_401_412 05.11.2005 10:37 Uhr Seite 401 Chapter 24 Patch Testing 24 in Adverse Drug Reactions Derk P.Bruynzeel, Margarida Gonçalo Contents Core Message 24.1 Introduction . 401 24.2 Pathomechanisms . 403 í A drug eruption is an adverse skin reaction 24.3 Patch Test Indications . 404 caused by a drug used in normal doses 24.4 Technique and Test Materials . 406 and presents a wide variety of cutaneous reactions. 24.5 Relevance and Consequences . 407 References . 408 24.1 Introduction A drug eruption is an adverse skin reaction caused by a drug used in normal doses. Systemic exposure to drugs can lead to a wide variety of cutaneous reac- tions, ranging from erythema, maculopapular erup- tions (the most frequent reaction pattern), acrovesic- ular dermatitis, localized fixed drug eruptions, to toxic epidermal necrolysis and from urticaria to anaphylaxis (Figs. 1, 2). The incidence of these erup- tions is not exactly known; 2%–5% of inpatients ex- perience such a reaction and it is a frequent cause of consultation in dermatology [1–3]. Topically applied drugs may cause contact dermatitis reactions. Topi- cal sensitization and subsequent systemic exposure may induce dermatological patterns similar to drug eruptions or patterns more typical of a systemic con- tact dermatitis, like the “baboon syndrome” (Chap. 16). It is clear that, in these situations, patch testing can be of great help as a diagnostic tool [4]. In patients with drug eruptions without previous contact sensitization, patch testing seems less logical, but is still a strong possibility, as systemic exposure of drugs may also lead to T-cell sensitization and to delayed type IV hypersensitivity reactions [5–8]. -
| Oa Tai Ei Rama Telut Literatur
|OA TAI EI US009750245B2RAMA TELUT LITERATUR (12 ) United States Patent ( 10 ) Patent No. : US 9 ,750 ,245 B2 Lemire et al. ( 45 ) Date of Patent : Sep . 5 , 2017 ( 54 ) TOPICAL USE OF AN ANTIMICROBIAL 2003 /0225003 A1 * 12 / 2003 Ninkov . .. .. 514 / 23 FORMULATION 2009 /0258098 A 10 /2009 Rolling et al. 2009 /0269394 Al 10 /2009 Baker, Jr . et al . 2010 / 0034907 A1 * 2 / 2010 Daigle et al. 424 / 736 (71 ) Applicant : Laboratoire M2, Sherbrooke (CA ) 2010 /0137451 A1 * 6 / 2010 DeMarco et al. .. .. .. 514 / 705 2010 /0272818 Al 10 /2010 Franklin et al . (72 ) Inventors : Gaetan Lemire , Sherbrooke (CA ) ; 2011 / 0206790 AL 8 / 2011 Weiss Ulysse Desranleau Dandurand , 2011 /0223114 AL 9 / 2011 Chakrabortty et al . Sherbrooke (CA ) ; Sylvain Quessy , 2013 /0034618 A1 * 2 / 2013 Swenholt . .. .. 424 /665 Ste - Anne -de - Sorel (CA ) ; Ann Letellier , Massueville (CA ) FOREIGN PATENT DOCUMENTS ( 73 ) Assignee : LABORATOIRE M2, Sherbrooke, AU 2009235913 10 /2009 CA 2567333 12 / 2005 Quebec (CA ) EP 1178736 * 2 / 2004 A23K 1 / 16 WO WO0069277 11 /2000 ( * ) Notice : Subject to any disclaimer, the term of this WO WO 2009132343 10 / 2009 patent is extended or adjusted under 35 WO WO 2010010320 1 / 2010 U . S . C . 154 ( b ) by 37 days . (21 ) Appl. No. : 13 /790 ,911 OTHER PUBLICATIONS Definition of “ Subject ,” Oxford Dictionary - American English , (22 ) Filed : Mar. 8 , 2013 Accessed Dec . 6 , 2013 , pp . 1 - 2 . * Inouye et al , “ Combined Effect of Heat , Essential Oils and Salt on (65 ) Prior Publication Data the Fungicidal Activity against Trichophyton mentagrophytes in US 2014 /0256826 A1 Sep . 11, 2014 Foot Bath ,” Jpn . -
Health Service
UNIVERSITY OF ILLINOIS HEALTH SERVICE Departments in Urbana-Champajgn Thirty,third Annual Report 1948-1949 J. How AID BEARD, M. D. University Health Officer Urbana, Illinois I have the honor to present herewith this report as edited and prepared by the late Dr. J. Howard Beard. 1'h* pr1ntinc and binding have been completed with., IUper- vision. TABLE OF CONTENTS Pall" FORE":1ORD 1 SERVICES 2 I. University Students 2 II. University High School Studente 2 III. Re t irc~9nt System 2 IV. Employees 6 V. Student and Private Pilots 7 VI. Foodhandler s 7 VII. Applicants for l-!arriage Certificates 7 VIII. Laboratory SerTice 7 9 I! General 9 II. Albuminuria 10 Ill. Hear ~ ~lBeaBe 10 IV. Tube~culosio 10 V. Mental Hygiene 11 VI. Oral Hygiene 12 COi>iM1Jl!ICABLE DISEASE 1) I. Students 1) II. Faculty and Civ!l SerTice Employees 14 VACCII'.ATIONS AJID UilltJllIZATIONS 14 COOPllRATION WITH CT!mR DEPARTMElITS 14 I. Military Classification 14 II. ~hysical Education Classification 14 INSTRUCTION IN I!YG IENE 15 I. Proficiency Examination 16 II. Hygiene 102 and 105, Elementary Hygiene and Sanitation 16 III. Hygiene 110, For Coachee and Teacheru 17 IV. nr6~ene 216, Por Occupational Therapy Student. 17 V. Hygiene X-103, Extension Course 17 VI. Hygiene X-225, Extension Course 17 SAl!ITATIOli 17 FIRST AID CABINETS 18 SPBCIAL SERV I C~ AT UN IVERSITY FJVbh~S 18 S TA~ !.ABORATORT Sz:RVICE 18 :uJqtm5TS FOR I NFCmiAT ION 19 TlrE GllNERAL PRACTITIONER AND '!'HE I!EA1TH SERVIClil 19 HOSPl TALlZATIOl1 19 I. McKinley Hospital 20 II. -
Verneuil and Verneuil's Disease: an Historical Overview
Chapter 2 Verneuil and Verneuil’s Disease: an Historical Overview 2 Gérard Tilles Key points 2.1 Biographical Landmarks of a Surgeon-Venereologist QHidradenitis suppurativa is a clinically well described entity Aristide Auguste Stanislas Verneuil (Fig. 2.1) was born in Paris on 29 November, 1823. He was QThe classification has been a continu- appointed Interne des Hôpitaux de Paris in ous source of debate for more than 1843, graduated as a Doctor in Medicine in 1852 100 years (thesis: the movements of the heart) and became Professeur Agrégé at the Paris Faculty of Medi- QThe lack of sweat gland involvement cine in 1853 (thesis: the anatomy and physiology has been described in early studies of the venous system). As Surgeon of the Paris Hospitals from 1856, he was officially in charge of the teaching of ve- nereal diseases from 1863. Non syphilitic vene- real diseases and primary syphilis were at this #ONTENTS time managed essentially by surgeons (for ex- ample, Ricord in Le Midi Hospital) whereas 2.1 Biographical Landmarks dermatologists – notably in Saint Louis – were of a Surgeon-Venereologist ................. 4 more involved in the management of secondary 2.2 L’Hidradénite Phlegmoneuse and tertiary forms of syphilis. (Verneuil’s Disease), Primary Observations .. 5 In fact dermatology and syphilology were 2.3 Further Observations and Discussions first regarded only as complementary special- in Europe and Overseas .................... 6 ties. Cazenave – head of Saint Louis Hospital – 2.4 HidrosadenitisandAcneConglobata: was in charge of teaching skin diseases from Controversial Views ....................... 8 1841 until 1843, succeeded by Hardy from 2.5 AcneInversa,theLastMetamorphosis 1862 [1]. -
Module Test № 2 on Venerology
THE MINISTRY OF HEALTHCARE OF THE RUSSIAN FEDERATION FEDERAL STATE BUDGETARY EDUCATIONAL INSTITUTION OF HIGHER PROFESSIONAL EDUCATION PIROGOV RUSSIAN NATIONAL RESEARCH MEDICAL UNIVERSITY DEPARTMENT OF DERMATOVENEROLOGY Gaydina T.A., Dvornikov A.S., Skripkina P.A., Nazhmutdinova D.K., Heydar S.A., Arutunyan G.B., Pashinyan A.G. MODULE TEST №2 ON VENEROLOGY FOR STUDENTS OF INSTITUTES OF HIGHER MEDICAL EDUCATION ON SPECIALTY THERAPEUTIC FACULTY DEPARTMENT OF DERMATOVENEROLOGY Moscow 2016 ISBN УДК ББК A21 Module test №2 on Venerology for students of institutes of high medical education on specialty «Therapeutic faculty» department of dermatovenerology: manual for students for self-training//FSBEI HPE “Pirogov RNRMU” of the ministry of healthcare of the russian federation, M.: (publisher) 2016, 80 p. The manual is a part of teaching-methods on Dermatovenerology. It contains tests on Venerology on the topics of practical sessions requiring single or multiple choice anser. The manual can be used to develop skills of students during practical sessions. It also can be used in the electronic version at testing for knowledge. The manual is compiled according to FSES on specialty “therapeutic faculty”, working programs on dermatovenerology. The manual is intended for foreign students of 3-4 courses on specialty “therapeutic faculty” and physicians for professional retraining. Authors: Gaydina T.A. – candidate of medical science, assistant of dermatovenerology department of therapeutic faculty Pirogov RNRMU Dvornikov A.S. – M.D., professor of dermatovenerology department of therapeutic faculty Pirogov RNRMU Skripkina P.A. – candidate of medical science, assistant professor of dermatovenerology department of therapeutic faculty Pirogov RNRMU Nazhmutdinova D.K. – candidate of medical science, assistant professor of dermatovenerology department of therapeutic faculty Pirogov RNRMU Heydar S.A. -
DRUG-INDUCED PHOTOSENSITIVITY (Part 1 of 4)
DRUG-INDUCED PHOTOSENSITIVITY (Part 1 of 4) DEFINITION AND CLASSIFICATION Drug-induced photosensitivity: cutaneous adverse events due to exposure to a drug and either ultraviolet (UV) or visible radiation. Reactions can be classified as either photoallergic or phototoxic drug eruptions, though distinguishing between the two reactions can be difficult and usually does not affect management. The following criteria must be met to be considered as a photosensitive drug eruption: • Occurs only in the context of radiation • Drug or one of its metabolites must be present in the skin at the time of exposure to radiation • Drug and/or its metabolites must be able to absorb either visible or UV radiation Photoallergic drug eruption Phototoxic drug eruption Description Immune-mediated mechanism of action. Response is not dose-related. More frequent and result from direct cellular damage. May be dose- Occurs after repeated exposure to the drug dependent. Reaction can be seen with initial exposure to the drug Incidence Low High Pathophysiology Type IV hypersensitivity reaction Direct tissue injury Onset >24hrs <24hrs Clinical appearance Eczematous Exaggerated sunburn reaction with erythema, itching, and burning Localization May spread outside exposed areas Only exposed areas Pigmentary changes Unusual Frequent Histology Epidermal spongiosis, exocytosis of lymphocytes and a perivascular Necrotic keratinocytes, predominantly lymphocytic and neutrophilic inflammatory infiltrate dermal infiltrate DIAGNOSIS Most cases of drug-induced photosensitivity can be diagnosed based on physical examination, detailed clinical history, and knowledge of drug classes typically implicated in photosensitive reactions. Specialized testing is not necessary to make the diagnosis for most patients. However, in cases where there is no prior literature to support a photosensitive reaction to a given drug, or where the diagnosis itself is in question, implementing phototesting, photopatch testing, or rechallenge testing can be useful. -
A Very Rare Case of Dissecting Cellulitis of the Scalp in an Indonesian Man
A Very Rare Case of Dissecting Cellulitis of the Scalp in an Indonesian Man Rizky Lendl Prayogo1, Lusiana1, Sri Linuwih Menaldi1, Sondang P. Sirait1, Eliza Miranda1 1Department of Dermatology and Venereology Faculty of Medicine Universitas Indonesia / Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia Keywords: dissecting cellulitis of the scalp, dissecting folliculitis, follicular occlusion tetrad, diagnosis, isotretinoin Abstract: Dissecting cellulitis of the scalp (DCS), also known as dissecting folliculitis, perifolliculitis capitis abscedens et suffodiens (PCAS), or Hoffman’s disease, is a primary neutrophilic cicatricial alopecia without clear etiology. Along with hidradenitis suppurativa, acne conglobata, and pilonidal cyst, they were recognized as ‘follicular occlusion tetrad’. A 43-year-old Indonesian man presented to our department with four years history of persistent, slightly painful subcutaneous nodules, abscesses, and sinuses that discharged purulent exudate on vertex and occipital scalp. There was also associated patchy alopecia. He had severe acne during his adolescence to early adulthood. Trichoscopic evaluation showed yellowish and whitish area lacking of follicular openings. Histopathological examination showed follicular occlusion, dilatation, and rupture with mixed inflammatory infiltrates, mainly neutrophils. The diagnosis of DCS was confirmed by clinical, trichoscopic, and histopathological examinations. Isotretinoin 20 mg daily was given to normalize the follicular keratinization. Considering its very rare occurrence in an Indonesia man, this case was reported to emphasize the diagnosis of DCS. 1 INTRODUCTION should be considered (Otberg & Shapiro, 2012; Scheinfeld, 2014). Considering its low prevalence in DCS, also known as dissecting folliculitis, PCAS, Indonesia, we are intrigued to report a case or Hoffmann’s disease, is a very rare primary emphasizing the diagnosis of DCS. -
Acne Conglobata Associated with Hidradenitis Suppurativa, Disorders of Follicular Occlusion (Case Report)
30 ACTA MEDICA MARTINIANA 2015 15/2 DOI: 10.1515/acm-2015-0009 ACNE CONGLOBATA ASSOCIATED WITH HIDRADENITIS SUPPURATIVA, DISORDERS OF FOLLICULAR OCCLUSION (CASE REPORT) Pecova K, jr. Department of of Dermatovenerology, Comenius University, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Slovakia Abstract The author is presenting the case of a 23-year-old female patient with a severe form of acne conglobata, with the first symptoms of the disease occurring as far back as the prepubertal age. In the past year the disease has com- bined with hidradenitis suppurativa (to be referred to henceforth as “HS”), Hurley stage I, in the axillae and both sides of the inguinal region, with a family history of acne conglobata (both her mother and brother were affected). Further examinations ruled out inflammatory bowel disease because of a lack of further associated symptoms, except for sideropenic anaemia (lesser form) and lower serum values of vitamin D. Up until now the disease has been resistant to treatment, including the long-term treatment of methylprednisolone in combination with isotretinoid as well as dapsone and antibiotics. Key words: acne conglobata, hidradenitis suppurativa, treatment INTRODUCTION Hidradenitis suppurativa (HS) may occur in combination with a severe form of acne (acne conglobata), dissecting cellulitis of the scalp and pilonidal sinus (pilonidal cysts) [1]. We present a case of the simultaneous occurrence of the symptoms of severe acne con- globata and HS. Case report A 23-year old female patient (175 cm tall, 60 kg weight, BMI -19.2), mother of two chil- dren, currently on maternal leave, with smoking being ruled out, and with her mother and brother having been treated for severe symptoms of acne conglobata.