MOLECULAR PHARMACOLOGY, 13, 1187-1194

AUTHOR INDEX FOR VOLUME 13

A Barnard, E. A. See Dolly, Albuquerque, Sarvey and Mallick, 1 Abood, L. G. See Wu, Gates and Kreilick, 766 Bauce, Lorenzo G. See Goren and Vale, 606 Adams, Ralph N. See Borchardt, Burgess, Reid and Bednarczyk, Donald J. and Medzihradsky, Fedor. Liang, 805 Mechanism of Chloroquine Transport in the Ahmed, KhaliI. See Foster, 142 Isolated Retina, 99 Akera, Tal. See Temma, Brody and Manian, 1076 Bergstrand, Hakan, Kristoffersson, Jan, Lund- Akhtar, Muhammad S. See Ammon, Nikias and quiet, Britta and Schurmann, Annika. Effects Hegner, 598 of Antiallergic Agents, Compound 48/80, and Aktipis, Stelios and Panayotatos, Nikos. The Inhib- Some Reference Inhibitors on the Activity of itory Effect of Phenanthridines on the Syn- Partially Purified Human Lung Tissue Aden- thesis of Ribonucleic Acid Catalyzed by De- osine Cyclic 3’,S’-Monophosphate and Gua- oxyribonucleic Acid-Dependent Ribonucleic nosine Cyclic 3’,5’-Monophosphate Phospho- Acid Polymerase, 706 diesterases, 38 Albuquerque, E. X. See Dolly, Sarvey, Mallick and Bertollini, Alberto. See Raiteri, del Carmine and Barnard, 1 Levi, 746 Ames, Matthew M. See Lerner and Louenberg, 44 Biaglow, John E., Jacobson, Birgit, Greenstock, Ammon, Hermann P. T., Akhtar, Muhammad S., Clive L. and Raleigh, James. Effect of Nitro- Nikias, H. and Hegner, D. Inhibition of p- benzene Derivatives on Electron Transfer in Chloromercuribenzoate- and Glucose-Induced Cellular and Chemical Models, 269 Insulin Release in Vitro by Methylene Blue, Bilezikian, John P., Spiegel, Allen M., Brown, Diamide, and tert-Butyl Hydroperoxide, 598 Edward M. and Aurbach, Gerald D. Identifi- Antholine, William, Knight, Judith, Whelan, Harry cation and Persistence of Beta Adrenergic and Petering, David H. Studies of the Reac- Receptors during Maturation of the Rat Re- tion of 2-Formylpyridine Thiosemicarbazone ticulocyte, 775 and Its Iron and Copper Complexes with Bilezikian, John P., Spiegel, Allen M., Gammon, Biological Systems, 89 Donald E. and Aurbach, Gerald D. The Role Aronow, Lewis. See Hjelmeland and Trudell, 634 of Guanyl Nucleotides in the Expression of Arya, S. K. and Chawda, R. Polyribonucleotide Catecholamine-Responsive Adenylate Cy- Inhibition of Murine Leukemia Virus Repli- class during Maturation of the Rat Reticulo- cation: Effect of Strandedness, 374 cyte, 786 Asa.no, Tomiko, Ochiai, Yasuo and Hidaka, Hiroy- Birkett, Donald J., Myers, Shirley P. and Sudlow, oshi. Selective Inhibition of Separated Forms Gillian. Effects ofFatty Acids on Two Specific of Human Platelet Cyclic Nucleotide Phos- Drug Binding Sites on Human Serum Albu- phodiesterase by Platelet Aggregation Inhib- mm, 987 itors, 400 Bockaert, Joel. See Lucas, 314 Aurbach, Gerald D. See Bilezikian, Spiegel and Bockaert, Joel. See Pr#{233}mont and Perez, 662 Brown, 775 Boobis, Alan R., Nebert, Daniel W. and Felton, Aurbach, Gerald D. See Bilezikian, Spiegel and James S. Comparison of f3-Naphthoflavone Gammon, 786 and 3-Methylcholanthrene as Inducers of He- Aust, Steven D. See Guengerich, 185 patic Cytochrome(s) P-448 and Aryl Hydro- carbon (Benzo[a]pyrene) Hydroxylase Activ- ity, 259 B Borchardt, Ronald T., Burgess, Susan K., Reid, Babb, Len R. See Paterson, Paran and Case, 1147 Jack R., Liang, Yueh-O and Adams, Ralph Bachur, Nicholas R., Gordon, Sandra L. and Gee, N. Effects of 2- and/or 5-Methylated Ana- Malcolm. Anthracycline Antibiotic Augmen- logues of6-Hydroxydopamine on Norepineph- tation of Microsomal Electron Transport and rine- and Dopamine-Containing Neurons, 805 Free Radical Formation, 901 Boyd, Helen and Martin, T. J. The Effect of Pro- Baguley, Bruce C. See Drummond and Staehelin, pranolol on Induction of Rat Liver Tumors by 1159 a Chemical Carcinogen, 576 Balaram, P. SeeKrishnan, 621 Brake, Emily T. See Will, Longworth and Cook, Banerjee, Shailesh P. See Sharma, 796 161

1187 Copyright C 1977 by Academic Press, Inc. All rights or reproduction in any form reserved. ISSN 0026-895X 1188 AUTHOR INDEX

Brody, Theodore M. See Temma, Akera and Man- Coward, James K. See Mic/telot, Lesko and Stout, ian, 1076 368 Brooker, Gary. See Harper, 1048 Coyle, J. T. See Grzanna, 956 Brown, Edward M. See Bilezikian, Speigel and Cubeddu X, Luigi and Vargas, Alba M. Effects of Aurbach, 775 Sodium Chloride on Phenylethanolamine-N- Brown, Nigel A., J#{225}hnchen, Eberhard, Muller, Methyltransferase Activity, 172 Walter E. and Wollert, Uwe. Optical Studies Curley, Winifred. See Koe/tler and Koehler, 113 on the Mechanism of the Interaction of the D Enantiomers of the Anticoagulant Drugs Dausse, J. P., Duval, D., Meyer, P., Gaignault, J. Phenprocoumon and Warfarin with Human C., Marchandeau, C. and Raynaud, J. P. Serum Albumin, 70 The Relationship between Glucocorticoid Burgess, Susan K. See Borchardt, Reid, Liang and Structure and Effects upon Thymocytes, 948 Adams, 805 De Clercq, E. , Krajewska, E., Descamps, J. and C Torrence, P. F. Anti-herpes Activity of Deox- ythymidine Analogues: Specific Dependence Cantoni, Giulio L. See Chiang and Richards, 939 on Virus-Induced Deoxythymidine Kinase, Carchman, Richard A. See End, Thoursen and 980 Dewey, 864 Degelaen, J. See Riga, Verbist, Tollenaere and Carter, William A. See Mayhew, Papa/tadjopoulas, Koch, 892 O’Malley and Vail, 488 del Carmine, Renata. See Raiteri, Bertollini and Carter, William A. See Milavetz, Horoszewicz, Eu- Levi, 746 ans, Manly and Rinehart, 496 Descamps, J. See De Clercq, Krajewska and Torr- Cass, Carol E. See Paterson and Naik, 1014 ence, 980 Case, Carol E. See Paterson, Babb and Paran, 1147 Deutschmann, Genevieve. See Wolf, Mansuy, Nas- Catt, Kevin J. See Conti, Harwood and Dufau, 1024 tainczyk and Ullrich, 698 Chawda, R. SeeArya, 374 Dewey, William L. See End, T/toursen and Carch- Chiang, Peter K., Richards, Henry H. and Cantoni, man, 864 Giulio L. S-Adenosyl-L-homocysteine Hydro- Di Paolo, Th#{233}r#{232}se,Kier, Lemont B. and Hall, lass: Analogues of S-Adenosyl-i-homocys- Lowell H. Molecular Connectivity and Struc- teine as Potential Inhibitors, 939 ture-Activity Relationship of General Anes- Chiesara, E. See Uemura and Cova, 196 thetics, 31 Chin, J. H. and Goldstein, D. B. Effects of Low Dolly, J. 0., Albuquerque, E. X., Sarvey, J. M., Concentrations of Ethanol on the Fluidity of Mallick, B. and Barnard, E. A. Binding of Spin-Labeled Erythrocyte and Brain Mem- Perhydro-histrionicotoxin to the Postsynaptic branes, 435 Membrane of Skeletal Muscle in Relation to Chu, Barbara C. F. and Whiteley, John M. High Its Blockade of Acetylcholine-Induced Depo- Molecular Weight Derivatives of Methotrex- larization, 1 ate as Chemotherapeutic Agents, 80 Drummond, Alan H. , Baguley, Bruce C. and Stae- Cinti, Dominick L. See Montgomery, 60 helm, Matthys. Beta Adrenergic Regulation Clark, Richard B. See Gross, 242 of Glycogen Phosphorylase Activity and Clay, George A., Mackerer, Carl R. and Lin, Teng Adenosine Cyclic 3’,S’-Monophosphate Accu- K. Interaction of Loperamide with mulation in Control and Desensitized C-6 [3H]Naloxone Binding Sites in Guinea Pig Astrocytoma Cells, 1159 Brain and Myenteric Plexus, 533 Dufau, Maria L. See Conti, Harwood and Catt, Cohen, Sasson. See Richter and Landau, 548 1024 Coleman, Mary Sue and Hutton, John J. Effects of Duval, D. See Dausse, Meyer, Gaignault, Marc/tan- Antineoplastic and Immunosuppressant Drugs deau and Raynaud, 948 on Deoxyribonucleic Acid-Polymerizing En- zymes of Rat Thymus and Spleen, 122 E Conney, A. H. See Wood, Levin, Lu, Ryan, West, Eigner, Ann. See Rando, 1005 Yogi, Mah and Jerina, 1116 el Azhary, Rokea. See Jeffery, Kotake and Manner- Conti, Marco, Harwood, James P., Dufau, Maria ing, 415 L. and Catt, Kevin J. Regulation of Luteiniz- Ellinger, Royal. See Lindell, Warren, Sundheimer ing Hormone Receptors and Adenylate Cy- and O’Malley, 426 clase Activity by Gonadotrophin in the Rat End, David W., Thoursen, Kenneth, Dewey, Wil- Ovary, 1024 ham L. and Carchman, Richard A. A Corn- Cook, John S. See Will, Longworth and Brake, 161 parative Study of the Disposition of (-)-- Corbin, Jackie D. See Keely and Lincoln, 965 Tetrahydrocannabinol in Neuroblastoma and Cova, D. See Uemura and Chiesara, 196 Glioma Cells in Tissue Culture: Relation to AUTHOR INDEX 1189

Cellular Impairment, 864 Wylie. Forces and Structural Limitations of Enna, S. J. and Snyder, Solomon H. Influences of Binding of Thyrotrophin-Releasing Factor to Ions, Enzymes, and Detergents on y-Amino- the Thyrotrophin-Releasing Receptor: the butyric Acid-Receptor Binding in Synaptic Pyroglutamic Acid Moiety, 606 Membranes of Rat Brain, 442 Greenberg, David A. See U’Prichard and Snyder, Evans, Mary Jo. See Milauetz, Horoszewicz, Manly, 454 Rinehart and Carter, 496 Greenberg, Jeffrey H. See Huszar and Mellors, 1086 Greenstock, Clive L. See Biaglow, Jacobson and F Raleigh, 269 Feinstein, M. B., Volpi, M., Perrie, S., Makriyan- Gross, Robert A. and Clark, Richard B. Regulation nis, A and Sha’afi, R. I. Mechanisms of Local ofAdenosine 3’,S’-Monophosphate Content in Anesthetic Action on the Permeability of Human Astrocytoma Cells by Isoproterenol Erythrocytes, Leukocytes, and Liposomes and Carbachol, 242 Containing the Erythrocyte Anion Channel Grzanna, R. and Coyle, J. T. Immunochemical Protein, 840 Studies on the Turnover of Rat Serum Dopa- Felton, James, S. See Boobis and Nebert, 259 mine f3-Hydroxylase, 956 Fickentscher, K., Kirfel, A., Will, G. and K#{246}hler, Guengerich, F. Peter and Aust, Steven D. Activa- F. Stereochemical Properties and Teratogenic tion of the Parasympathomimetic Alkaloid Activity of Some Tetrahydrophthalimides, Slaframine by Microsomal and Photochemi- 133 cal Oxidation, 185 Fletcher, John E. and Spector, Arthur A. Alterna- Guengerich, F. Peter. Preparation and Properties tive Models for the Analysis of Drug-Protein of Highly Purified Cytochrome P-450 and Binding, 387 NADPH-Cytochrome P-450 Reductase from Foster, Donald and Ahmed, Khalil. Solvent Effects Pulmonary Microsomes of Untreated Rabbits, on Hydrolysis of the Phosphoenzyme Inter- 911 mediate in Sodium- and Potassium-Depend- Guengerich, F. Peter and Strickland, Thomas W. ent Adenosine Triphosphatase: Correlations Metabolism of Vinyl Chloride: Destruction of with Stimulation of Potassium-Dependent p- the Heme of Highly Purified Liver Micro- Nitrophenyl Phosphatase, 142 somal Cytochrome P-450 by a Metabolite, 993 Freeman, Karl B., Patel, Hasmukh and Haldar, Gund, P., Poe, M. and Hoogsteen, K. H. Calcula- Dipak. Inhibition of Deoxyribonucleic Acid tions by Complete Neglect of Differential Synthesis in Ehrlich Ascites Cells by Chior- Overlap (CNDO/2) on Dihydrofolic Acid: Role amphenicol, 504 of N(5) in Reduction by Dihydrofolate Reduc- tase, 1111 G H Gaignault, J. C. See Dausse, Duval, Meyer, Mar- c/tandeau and Raynaud, 948 Haldar, Dipak. See Freeman and Patel, 504 Galardy, Richard E. and Jamieson, James D. Pho- Hall, Lowell H. See Di Paolo and Kier, 31 toaffinity Labeling of a Peptide Secretagogue Harden, T. Kendall. See Sporn, Wolfe and Molinoff, Receptor in the Exocrine Pancreas, 852 1170 Gammon, Donald E. See Bilezikian, Spiegel and Harmar, A. J. and Horn, A. S. Octopamine-Sensi- Aurbach, 786 tive Adenylate Cyclase in Cockroach Brain: Gerber, Alan J. Inhibition by Serotonin of Amino Effects ofAgonists, Antagonists, and Guanylyl Acid Release and Protein Degradation in Nucleotides, 512 Skeletal Muscle, 640 Harper, Jeffrey F. and Brooker, Gary. Refractori- GarcIa-Casti#{241}eiras, Sixto, White, John I. and Toro- ness to Muscarinic and Adrenergic Agonists Goyco, EfraIn. Inhibition of Sodium- and in the Rat Parotid: Responses of Adenosine Potassium-Dependent Adenosine Triphos- and Guanosine Cyclic 3’ ,5’-Monophosphates, phatase by Serotonin, 181 1048 Gates, M. See Wu, Abood and Kreilick, 766 Hartley, Robert W. See Klein, Weller and Kirk, Gee, Malcolm. See Bachur and Gordon, 901 1105 Gielen, Jacques E. See Kano, Yagi, Jerina and Harwood, James P. See Conti, Dufau and Catt, Nebert, 1181 1024 Glover, Edward. See Poland, 924 Hashiguchi, Hideo and Takahashi, Hitoshi. Inhibi- Goldberg, B. and Stern, A. The Mechanism of tion of Two Copper-Containing Enzymes, Ty- Oxidative Hemolysis Produced by Phenylhy- rosinase and Dopamine f3-Hydroxylase, by L- drazine, 832 Mimosine, 362 Goldstein, D. B. See Chin, 435 Hegner, D. See Ammon, Akhtar and Nikias, 598 Gordon, Sandra L. See Bachur and Gee, 901 Heller, Michael J. See Walder, Hyman, Shishido Goren, H. Joseph, Bauce, Lorenzo G. and Vale, and Klotz, 407 1190 AUTHOR INDEX

Hidaka, Hiroyoshi. See Asano and Ochiai, 400 quirement for Metabolism of Polycyclic Hy- Hinson, Jack A., Nelson, Sidney D. and Mitchell, drocarbon Inducer, 1181 Jerry R. Studies on the Microsomal Forma- Kirk, Kenneth L. See Klein, Weller and Hartley, tion of Arylating Metabolites of Acetamino- 1105 phen and Phenacetin, 625 Klein, David C., Weller, Joan L., Kirk, Kenneth L. Hjelmeland, Leonard M., Aronow, Lewis and Tru- and Hartley, Robert W. Incorporation of 2- dell, James R. Intramolecular Determination Fluoro-L-histidine into Cellular Protein, 1105 of Substituent Effects in Hydroxylations Cat- Krajewska, E. See De Clercq, Descamps and Torr- alyzed by Cytochrome P-450, 634 ence, 980 Holbrook, David J., Jr. See Krasny, 759 Kapetanovic, I. M. See Novak and Mieyal, 15 Hollenberg, Morley D. Steroid-Stimulated Amino Katsuki, Shoji and Murad, Fend. Regulation of Acid Uptake in Cultured Human Fibroblasts Adenosine Cyclic 3’,S’-Monophosphate and Reflects Glucocorticoid and Anti-inflamma- Guanosine Cyclic 3’,S’-Monophosphate Lev- tory Potency, 150 els and Contractility in Bovine Tracheal Hoogsteen, K. H. SeeGundandPoe, 1111 Smooth Muscle, 330 Horn, A. S. See Harmar, 512 Katz, Robert, Yeh, Herman J. C. and Johnson, Horoszewicz, Julius S. See Milavetz, Evans, Manly, David F. Interactions of Biogenic Amines Rinehart and Carter, 496 with Organic Phosphate: A Proposed Model Hoss, Wayne and Smiley, Constance. Immobiliza- in Vitro for Study of Biological Interactions tion of Opiates by Membrane Lipids, 251 by 31P Nuclear Magnetic Resonance, 615 Huszar, Leslie A., Greenberg, Jeffrey H. and Mel- Keely, Stanley L., Corbin, Jackie D. and Lincoln, lors, Alan. Effects of A-Tetrahydrocannabi- Thomas. Alp/ta Adrenergic Involvement in nol on Lymphocyte and Synaptosomal Lyso- Heart Metabolism: Effects on Adenosine phosphatidylcholine Acyltransferases in Vivo, Cyclic 3’,5’-Monophosphate, Adenosine Cyclic 1086 3’,5’-Monophosphate-Dependent Protein Ki- Hutton, John J. See Coleman, 122 nase, Guanosine Cyclic 3’,5’-Monophosphate, Hyman, Bradley, T. See Walder, Heller, Shishido and Glucose Transport, 965 and Klotz, 407 Kelleher, Joanne K. Tubulin Binding Affinities of Podophyllotoxin and Colchicine Analogues, 232 Iba, Michael M., Soyka, Lester F. and Schulman, Kier, Lemont B. See Di Paolo and Hall, 31 Martin P. Characteristics of the Liver Micro- Kirfel, A. See Fickentscher, Will and K#{246}hler, 133 somal Drug-Metabolizing Enzyme System of Kirshner, Norman. See Wilson, 382 Newborn Rats, 1092 Klotz, Irving M. See Walder, Hyman, Heller and Shishido, 407 J Knight, Judith. See Antholine, Whelan and Peter- Jacobson, Birgit. See Biaglow, Greenstock and Ra- ing, 89 leigh, 269 Koch, M. J. J. See Riga, Verbist, Degelaen and J#{225}hnchen, Eberhard. See Brown, Muller and Wol- Tollenaere, 892 lert, 70 Koehler, Karl A. See Koehler and Curley, 113 Jamieson, James D. See Galardy, 852 Koehler, Lynda S., Curley, Winifred and Koehler, Jeffery, Elizabeth, Kotake, Alvin, el Azhary, Rokea Karl A. Solvent Effects on Halothane: isF and Mannering, G. J. Effects of Linoleic Acid Nuclear Magnetic Resonance in Solvents and Hydroperoxide on the Hepatic Monooxygen- Artificial Membranes, 113 ase Systems of Microsomes from Untreated, K#{246}hler,F. See Fickentscher, Kirfel and Will, 133 Phenobarbital-Treated, and 3-Methylcholan- Kotake, Alvin. See Jeffery, el Azhary and Manner- threne-Treated Rats, 415 ing, 415 Jerina, Donald M. See Kano, Gielen, Yagi and Krasny, Harvey C. and Holbrook, David J., Jr. Nebert, 1181 Effects of Cadmium on Microsomal Hemopro- Jerina, D. M. See Wood, Levin, Lu, Ryan, West, teins and Heme Oxygenase in Rat Liver, 759 Yagi, Mah and Conney, 1116 Kraus, J. L. and Yaouanc, J. J. Inactivation of a Johnson, David F. See Katz and Yeh, 615 Flavin-Linked Oxide.se, N,N-Dimethylglycine Oxidase, in Vivo and in Vitro, 378 K Kreilick, R. W. See Wu, Abood and Gates, 766 Kano, Itsu, Gielen, Jacques E., Yagi, Haruhiko, Krishnan, K. S. and Balaram, P. Nuclear Magnetic Jerina, Donald M. and Nebert, Daniel W. Resonance Studies of the Enzymatic Hydrol- Subcellular Events Occurring during Aryl ysis of Acetylcholine: a Critical Comment, Hydrocarbon Hydroxylase Induction: No Re- 621 AUTHOR INDEX 1191

Kristoffersson, Jan. See Bergstrand, Lundquist and Lovenberg, Walter. See Rosenberg, 652 Schurmann, 38 Lu, Anthony Y. H. See Thomas, West, Ryan, Miwa and Leuin, 819 L Lu, A. Y. H. See Wood, Levin, Ryan, West, Yagi, Jerina Landau, Emmanuel M. See Richter and Cohen, 548 Mah, and Conney, 1116 Lamer, Joseph. See Lawrence, 1060 Lucas, Marguerite and Bockaert, Joel. Use of (-)- LaRusso, Nicholas F., Tomasz, Maria, Muller, [3H]Dihydroalprenolol to Study Beta Adre- Mikl#{243}sand Lipman, Roselyn. Interaction of nergic Receptor-Adenylate Cyclase Coupling Metronidazole with Nucleic Acids in Vitro, in C6 Glioma Cells: Role of 5’-Guanylylimi- 872 dodiphosphate, 314 Lauzon, Gilles J. and Paterson, Alan R. P. Binding Lundquist, Britta. See Bergstrand, Krthtoffersson of the Nucleoside Transport Inhibitor Nitro- and Schurmann, 38 benzylthioinosine to HeLa Cells, 883 M Lawrence, John C., Jr. and Lamer, Joseph. Evi- dence for Alpha Adrenergic Activation of Mackerer, Carl R. See Clay and Lin, 533 Phosphorylase and Inactivation of Glycogen Maeno, Hiroo. SeeNishikori and Takenaka, 671 Synthase in Rat Adipocytes. Effects of Alpha Mah, H. D. See Wood, Leuin, Lu, Ryan, West, Yagi, and Beta Adrenergic Agonists and Antago- Jerirta and Conney, 1116 fists on Glycogen Synthase and Phosphoryl- Makriyannis, A. See Feinstein, Volpi, Perrie and ase, 1060 Sha’afi, 840 Lee, A. G. Local Anesthesia: the Interaction be- Mallick, B. See Dolly, Albuquerque, Sarvey and tween Phospholipids and Chlorpromazine, Barnard, 1 Propranolol, and Practolol, 474 Manian, Albert. See Temma, Akera and Brody, Lefkowitz, Robert J. See Mukherjee, 291 1076 Lefkowitz, Robert J. See Williams, 304 Manly, Kenneth F. See Milauetz, Horoszewicz, Eu- Lerner, Pauline, Ames, Matthew M. and Loven- ans, Rinehart and Carter, 496 berg, Walter. The Effect of Ethylene Glycol Mannering, G. J. See Jeffery, Kotake and el Azhary, Bis(f3-aminoethyl ether)-N,N’-tetraacetic Acid 415 and Calcium on Tyrosine Hydroxylase Activ- Mansuy, Daniel. See Wolf, Nastainczyk, Deutsch- ity, 44 mann and Ulirich, 698 Lesko, Nadine. See Michelot, Stout and Coward, Marchandeau, C. See Dausse, Duval, Meyer, Gaig- 368 nault and Raynaud, 948 Levi, Giulio. See Raiteri, Del Carmine and Bertol- Martin, T. J. SeeBoyd, 576 lini, 746 Mayhew, Eric, Papahadjopoulos, Demetrios, Levin, Robert M. and Weiss, Benjamin. Binding of O’Malley, Judith A., Carter, William A. and Trifluoperazine to the Calcium-Dependent Vail, W. J. Cellular Uptake and Protection Activator of Cyclic Nucleotide Phosphodies- against Virus Infection by Polyinosinic-Poly- terase, 690 cytidylic Acid Entrapped within Phospholipid Levin, Wayne. See Ryan and Thomas, 521 Vesicles, 488 Levin, Wayne. See Thomas, Lu, West, Ryan and McClure, William 0. and Paulson, James C. The Miwa, 819 Interaction of Colchicine and Some Related Levin, W. See Wood, Lu, Ryan, West, Yagi, Mah, Alkaloids with Rat Brain Tubulin, 560

Jerina and Conney, 1116 Medzihradsky, Fedor. See Bednarczyk , 99 Liang, Yueh-O. See Borchardt, Burgess, Reid and Meisner, Herman. Displacement of Free Fatty Acids Adams, 805 from Albumin by Chlorophenoxyisobutyrate, Lin, Teng K. See Clay and Mackerer, 533 224 Lincoln, Thomas. See Keely and Corbin, 965 Mellors, Alan. See Huszar and Greenberg, 1086 Lindell, Thomas J., Ellinger, Royal, Warren, Meyer, P. See Dausse, Duual, Gaignault, Marc/tan- James T., Sundheimer, David and O’Malley, deau and Raynaud, 948 Anthony F. The Effect of Acute and Chronic Michelot, Robert J., Lesko, Nadine, Stout, Richard Phenobarbital Treatment on the Activity of W. and Coward, James K. Effect of S-Adeno- Rat Liver Deoxyribonucleic Acid-Dependent syihomocysteine and S-Tubercidinylhomocys- Ribonucleic Acid Polymerases, 426 tome on Catecholamine Methylation in Neu- Lipman, Roselyn. See LaRusso, Tomasz and roblastoma Cells, 368 Muller, 872 Mieyal, J. J. See Novak and Kapetanovic, 15 Longworth, James W. See Will, Brake and Cook, Milavetz, Barry I., Horoszewicz, Julius S., Evans, 161 Mary Jo, Manly, Kenneth F., Rinehart, Ken- Lovenberg, Walter. See Lamer and Ames, 44 neth L., Jr. and Carter, William A. Reverse 1192 AUTHOR INDEX

Transcription, a Probe by the Immobilized O’Malley, Anthony F. See Lindell, Ellinger, Warren Template Poly(adenylic acid)-Agarose, 496 and Sundheimer, 426 Minneman, Kenneth P. Postsynaptic Induction of O’Malley, Judith A. See Mayhew, Papa hadjopoulos, Serotonin N-Acetyltransferase Activity and Carterand Vail, 488 the Control of Cyclic Nucleotide Metabolism in Organ Cultures of the Rat Pineal, 735 P Mitchell, Jerry R. See Hinson and Nelson , 625 Miwa, Gerald T. See Thomas, Lu, West, Ryan and Palatini, Pietro. Mechanism of Inhibition of So- Levin, 819 dium- and Potassium-Dependent Adenosine Molinoff, Perry B. See Sporn, Wolfe and Harden, Triphosphatase by Tricyclic Antipsychotics, 216 1170 Montgomery, Mark R. and Cinti, Dominick L. Panayotatos, Nikos. SeeAktipis, 706 Pyridine Nucleotide-Dependent Electron Papahadjopoulos, Demetrios. See Mayhew, Transport in Kidney Cortex Microsomes: In- O’Malley, Carter and Vail, 488 teraction with Desaturase and Other Micro- Paran, John H. See Paterson, Babb and Cass, 1147 somal Mixed-Function Oxidases, 60 Patel, Hasmukh. See Freeman and Haldar, 504 Mukherjee, Chhabirani and Lefkowitz, Robert J. Paterson, Alan R. P. See Lauzon , 883 Regulation of Beta Adrenergic Receptors in Paterson, Alan R. P., Naik, Shambu R. and Cass, Isolated Frog Erythrocyte Plasma Mem- Carol E. Inhibition of Uridine Uptake in branes, 291 HeLa Cells by Nitrobenzylthioinosine and Muller, Mikl#{243}s.See LaRusso, Tomasz and Lipman, Related Compounds, 1014 872 Paterson, Alan R. P., Babb, Lori R., Paran, John Muller, Walter E. See Brown, Jdhnchen and Wol- H. and Cass, Carol E. Inhibition by Nitroben- lert, 70 zylthioinosine of Adenosine Uptake by Asyn- Murad, Fend. SeeKatsuki, 330 chronous HeLa Cells, 1147 Myers, Shirley P. SeeBirkett and Sudlow, 987 Paulson, James C. See McClure, 560 Perez, Mich#{232}le.See Pr#{233}mont and Bockaert, 662 N Perrie, S. See Feinstein, Volpi, Makriyannis and S/ta’afi, 840 Nahorski, S. R. Altered Responsiveness of Cerebral Petering, David H. See Antholine, Knight and Whe- Beta Adrenoceptors Assessed by Adenosine Ian, 89 Cyclic 3’ ,5’-Monophosphate Formation and Piper, Walter N. and van Lier, Robert B. L. Pteri- [3H]Propranolol Binding, 679 dine Regulation of Inhibition of Hepatic Uro- Naik, Shambu R. See Paterson and Cass, 1014 porphyrinogen I Synthetase Activity by Lead Narayanan, Njanoor and Sulakhe, Prakash V. 5’- Chloride, 1126 Guanylylimidodiphosphate-Activated Ade- Poat, Judith A. See Roberts and Woodruff, 541 nylate Cyclase of Cardiac Sarcolemma Dis- Poe, M. SeeGundandHoogsteen, 1111 plays Higher Affinity for Magnesium Ions, Poland, Alan and Glover, Edward. Chlorinated Bi- 1033 phenyl Induction of Aryl Hydrocarbon Hy- Nastainczyk, Wolfgang. See Wolf, Mansuy, droxylase Activity: a Study of the Structure- Deutschmann and Ullrich , 698 Activity Relationship, 924 Nebert, Daniel W. See Boobis and Felton , 259 Pr#{233}mont, Joel, Perez, Mich#{232}leand Bockaert, Joel. Nebert, Daniel W. See Kano, Gielen, Yagi and Adenosine-Sensitive Adenylate Cyclase in Jerina, 1181 Rat Striatal Homogenates and Its Relation- Nelson, Sidney D. See Hinson and Mitchell, 625 ship to Dopamine- and Ca2-Sensitive Ade- Niklas, H. SeeAmmon, Ak/ttar and Hegner, 598 nylate Cyclases, 662 Nishikori, Koji, Takenaka, Toichi and Maeno, Hi- roe. Stimulation of Microsomal Calcium Up- take and Protein Phosphorylation by Adeno- R sine Cyclic 3’,5’-Monophosphate in Rat Raiteri, Maurizio, del Carmine, Renata, Bertollini, Uterus, 671 Alberto and Levi, Giulio. Effect of Desmeth- Novak, R. F., Kapetanovic, I. M. and Mieyal, J. J. ylimipramine on the Release of [3HlNor- Nuclear Magnetic Resonance Studies of Sub- epinephrine Induced by Various Agents in strate-Hemoprotein Complexes in Solution. Hypothalamic Synaptosomes, 746 I. The Interaction of Xylidine with Myoglo- Rajalakshmi, S. See Sarma and Zubroff, 719 bin, Hemoglobin, and Cytochrome P450, 15 Raleigh, James. See Biaglow, Jacobson and Green- stock, 269 0 Rando, Robert R. The Fluorescent Labeling of Mi- Ochiai, Yasuo. SeeAsano and Hidaka, 400 tochondnial Monoamine Oxidase, 726 AUTHOR INDEX 1193

Rando, Robert R. and Eigner, Ann. The Pseudoir- The Effect of 6-Hydroxydopamine on Specific reversible Inhibition of Monoamine Oxidase [3HlOuabain Binding to Some Sympatheti- by Allylamine, 1005 cally Innervated Organs ofthe Cat, 796

Raynaud, J. P. See Dausse, Duval, Meyer, Gaig- Shishido, Roxanne Y. See Walder, Hyman , Heller nault and Marchandeau, 948 and Klotz, 407

Reid, Jack R. See Borchardt, Burgess, Liang and Smiley, Constance. See Hoss , 251 Adams, 805 Snyder, Solomon H. See Enna, 442 Richards, Henry H. See Chiang and Cantoni, 939 Snyder, Solomon H. See U’Prichard and Greenberg, Richter, Jacob, Landau, Emmanuel and Cohen, 454 Sasson. The Action of Volatile Anesthetics Soyka, Lester F. See Iba and Schulman , 1092 and Convulsants on Synaptic Transmission: Spector, Arthur A. See Fletcher, 387 a Unified Concept, 548 Spiegel, Allen M. See Bilezikian, Brown and Aur- Riga, J., Verbist, J. J., l)egelaen, J., Tollenaere, J. bach, 775 P. and Koch, M. H. J. Electron Densities in Spiegel, Allen M. See Bilezikian, Gammon and Neuroleptics by X-ray Photoelectron Spec- Aurbac/t, 786 troscopy, ‘C Nuclear Magnetic Resonance, Sporn, Jonathon R., Wolfe, Barry B., Harden, T. and Quantum Calculations on Model Com- Kendall and Molinoff, Perry B. Supersensi- pounds, 892 tivity in Rat Cerebral Cortex: Pre- and Post- Rinehart, Kenneth L, Jr. See Milavetz, Horoszewicz, synaptic Effects of 6-Hydroxydopamine at Evans, Manly and Carter, 496 Noradrenergic Synapses, 1170 Ritchie, J. M. and Rogart, R. B. Characterization Staehelin, Matthys. See Drummond and Baguley, of Exchange-Labeled Saxitoxin and the Origin 1159 of Linear Uptake by Excitable Tissue, 1136 Stern, A. See Goldberg, 832 Roberts, P. J., Woodruff, G. N. and Poat, Judith Stout, Richard W. See Michelot, Lesko and Coward, A. Binding of a Conformationally Restricted 368 Dopamine Analogue, 2-Amino-6,7-dihydroxy- Strickland, Thomas W. See Guengerich , 993 1,2,3,4-tetrahydronaphthalene, to Receptors Sudlow, Gillian. See Birkett and Myers, 987 on Rat Brain Synaptic Membranes, 541 Sulakhe, Prakash V. See Narayanan , 1033 Rogart, R. B. See Ritchie, 1136 Sundheimer, David. See Lindell, Ellinger, Warren Rosenberg, Robert C. and Lovenberg, Walter. Ac- and O’Malley, 426 tive Dimers of Dopamine f3-Hydroxylase in Human Plasma, 652 I Ryan, Dene E., Thomas, Paul E. and Levin, Wayne. Properties of Purified Liver Micro- Takahashi, Hitoshi. See Hashiguchi, 362 somal Cytochrome P450 from Rats Treated lakenaka, loichi, See Nishikori and Maeno, 671 with the Polychlorinated Biphenyl Mixture lemma, Kyosuke, Akera, Tai, Brody, Theodore M. Aroclor 1254, 521 and Manian, Albert A. Hydroxylated Chlor- Ryan, Dene. See Thomas, Lu, West, Miwa and promazine Metabolites: Positive Inotropic Ac- Levin, 819 tion and the Release of Catecholamines, 1076 Ryan, D. See Wood, Levin, Lu, West, Yagi, Mah, Thomas, Paul E. See Ryan and Leuin, 521 Jerina and Conney, 1116 Thomas, Paul E., Lu, Anthony Y. H., West, Susan B., Ryan, Dene, Miwa, Gerald I. and Levin, Wayne. Accessibility of Cytochrome P450 in S Microsomal Membranes: Inhibition of Metab- Sarma, D. S. R., Zubroff, J. and Ra.jalakshmi, S. olism by Antibodies to Cytochrome P450, 819 Repair in Vivo ofLiver Deoxyribonucleic Acid Thoursen, Kenneth. See End, Dewey and Carch- Damaged by Hycanthone and Related Com- man, 864 pounds, 719 Tollenaere, J. P. See Riga, Verbist, Degelaen and Sarvey, J. M. See Albuquerque, Dolly, Mallick and Koch, 892 Barnard, 1 Tomasz, Maria. See LaRusso, Muller and Lipman, Schmidt, Jakob. Drug Binding Properties of an a- 872 Bungarotoxin-Binding Component from Rat loro-Goyco, EfraIn. See GarcIa-Casti#{241}eiras and Brain, 283 White, 181 Schulman, Martin P. Seelba and Soyka, 1092 Torrence, P. F. See De Clercq, Krajewska and Des- Schurmann, Annika. See Bergstrand, Kristoffersson camps, 980 and Lundquist, 38 Triner, Lubos, Vulliemoz, Yvonne and Verosky, Sha’afi, R. I. See Feinstein, Volpi, Perrie and Mak- Mariagnes. The Action of Halothane on Ado- riyannis, 840 nylate Cyclase, 976 Sharma, Virendra K. and Banerjee, Shailesh P. Trudell, James R. See Hjelmeland and Aronow, 634 1194 AUTHOR INDEX

U lular Drug (Ouabain) Sequestration as a Mechanism of Detoxification, 161 Uemura, T., Chiesara, E. and Cova, D. Interaction Williams, Lewis T. and Lefkowitz, Robert J. Molec- of Epinephrine Metabolites with the Liver ular Pharmacology of Alp/ta Adrenergic Re- Microsomal Electron Transport System, 196 ceptors: Utilization of [3HlDihydroergo- Ughetto, Giovanni and Waring, Michael J. Confor- cryptine Binding in the Study of Pharmaco- mation of the Deoxyribonucleic Acid-Binding logical Receptor Alterations, 304 Peptide Antibiotic Echinomycin Based on En- Wilson, Steven P. and Kirshner, Norman. Locali- ergy Calculations, 579 zation of Adenylate Cyclase in Adrenal Me- Ulirich, Volker. See Wolf, Mansuy, Nastainczyk dulla, 382 and Deutschmann, 698 White, John I. See GarcIa-Casti#{241}eiras and Toro- U’Prichard, David C., Greenberg, David A. and Goyco, 181 Snyder, Solomon H. Binding Characteristics Wolf, C. Roland, Mansuy, Daniel, Nastainczyk, of a Radiolabeled Agonist and Antagonist at Wolfgang, Deutschmann, Genevieve and Ull- Central Nervous System Alp/ta Noradrener- rich, Volker. The Reduction of Polyhalogen- gic Receptors, 454 ated Methanes by Liver Microsomal Cyto- V chrome P450, 698 Wolfe, Barry B. See Sporn, Harden and Molinoff, Vail, W. J. See Mayhew, Papa/tadjopoulos, O’Malley 1170 and Carter, 488 Wollert, Uwe. See Brown, Jdhnchen and Muller, 70 Vale, Wylie. See Goren and Bauce, 606 Wood, James S. Heme Regulation of Cytochrome van Lier, RObert B. L. See Piper, 1126 Oxidase Synthesis in Fetal Rat Liver, 50 Vargas, Alba M. See Cubeddu X. , 172 Wood, A. W., Levin, W., Lu, A. Y. H., Ryan, D., Verbist, J. J. See Riga, Degelaen, Tollenaere and West, S. B., Yagi, H., Mah, H. D., Jerina, Koch, 892 D. M. and Conney, A. H. Structural Require- Verosky, Mariagnes. See Triner and Vulliemoz, 976 ments for the Metabolic Activation of Volpi, M. See Feinstein, Perrie, Makriyannis and Benzo[alpyrene to Mutagenic Products: Ef- Sha’afi, 840 fects of Modifications in the 4,5-, 7,8-, and Vulliemoz, Yvonne. See Triner and Verosky, 976 9,10-Positions, 1116 Woodruff, G. N. See Roberts and Poat, 541 W Wu, W. Y., Abood, L. G., Gates, M. and Kreilick, Walder, Joseph A., Hyman, Bradley T., Heller, R. W. Spin-Labeled Narcotics, 766 Michael J., Shishido, Roxanne Y. and Klotz, Irving M. Reversible Acylation and Inhibi- Y tion of Aggregation of Platelets by Substi- tuted Maleic Anhydrides, 407 Yagi, Haruhiko. See Kano, Gielen, Jerina and Ne- Waring, Michael J. See Ughetto, 579 bert, 1181 Warren, James T. See Lindell, Ellinger, Sundhei- Yagi, H. See Wood, Leuin, Lu, Ryan, West, Mah, mer and O’Malley, 426 Jerina and Conney, 1116 SeeKraus, Weiss, Benjamin. See Leuin , 690 Yaouanc, J. J. 378 Weller, Joan L. See Klein, Kirk and Hartley, 1105 Yeh, Herman J. C. See Katz and Johnson, 615 West, Susan B. See Thomas, Lu, Ryan, Miwa and Yoda, Atsunobu and Yoda, Shizuko. Association Leuin, 819 and Dissociation Rate Constants of the Corn- plexes between Various Cardiac Aglycones West, S. B. See Wood, Leuin, Lu, Ryan, Yagi, Mah, and Sodium- and Potassium-Dependent Jerina and Conney, 1116 Adenosine Triphosphatase Formed in the Whelan, Harry. See Ant/toline, Knight and Peter- Presence of Magnesium and Phosphate, 352 ing, 89 Yoda, Shizuko. See Yoda, 352 Whiteley, John M. See Chu, 80 Will, G. See Fickentscher, Kirfel and K#{246}/tler, 133 Z Will, Peter C., Longworth, James W., Brake, Em- ily T. and Cook, John S. Analysis of Intracel- Zubroff, J. See Sarma and Rajalaks/tmi, 719 MOLECULAR PHARMACOLOGY, 13, 1195-1199

SUBJECT INDEX FOR VOLUME 13

A /3-Adrenergic receptor, in frog erythrocyte, 291 Acetaminophen, 625 in C6 Glioma cells, 314 Acetylcholine, 330 in rat liver, 576 hydrolysis, NMR, 621 in chick brain, 629 Acetylcholine receptor, 1, 283 in rat pineal gland, 735 in rat brain, 283 in rat erythrocytes, 775 Acetylcholinesterase, 621 in rat heart, 965 Acetylsalicylic acid, 402 in C6 astrocytoma cells, 1159 Actinomycin D, 1024 in rat parotid gland, 1048 DNA polymerases, 122 in rat brain, 1170 Adenosine, 242, 400, 679 Adrenochrome, 196 sensitive adenylate cyclase, 662 Adrenocorticotropic hormone, 1060 transport, 1147 Adriamycin, 901 Adenosine deaminase, 122, 939 y-Aminobutyric acid, in rat thymus and spleen, 122 binding to rat brain sites, 442 Adenosine 3’,5’-monophosphate, 38, 242, 291, 330, 5-Aminolevulinic acid dehydratase, 1126 400, 640, 671, 679, 735, 965, 1048, 1060, 1159, Aminopyrine demethylase, 759 1170 Aminopyrine N-demethylase, 924 Adenosine triphosphatase (Na + Ki Amphetamine, 99 phosphorylated intermediate, 142 chioroquine transport, 99 rat brain, 142 Aniline hydroxylase, 759 solvent effect, 142 Ansamycins, 496 in HeLa cells, 161 Anthracyclines, inhibition by serotonin, 181 and electron transport, 901 interaction with thioxanthenes, 216 Anti-allergic agents, 38 interaction with phenothiazine, 216 cyclic nucleotide phosphodiesterase, 38 cardiac aglycone binding, 352 Antimycin-A, 269 in sympathetic nerve endings, 796 Aroclor-1254, in guinea pig hearts, 1076 cytochrome P-450 inducer, 521 S-Adenosylhomocysteine, 368, 739 aryl hydrocarbon hydroxylase, 924 S-Adenosylmethionine, 172, 939 Aryl hydrocarbon hydroxylase, 60, 196, 259, 634, Adenylate cyclase, 759, 924, 1181 in frog erythrocytes, 291 Ascorbic acid, 242 in C6 glioma cells, 314 Atropine, 330 in tracheal smooth muscle, 330 in bovine adrenal medulla, 382 B in cockroach brain, 512 Benzo[a]pyrene, 521, 698, 911, 1116, 1181 in striatum, 541, 662 in rat liver, 576 3,4-Benzpyrene hydroxylase, 60, 196, 259 in chick brain, 679 Bicuculline, 442 in bovine brain, 690 Binding studies, in rat pineal gland, 735 equilibrium dialysis, 70 in rat erythrocytes, 775, 786 circular dichroism, 70 in rat heart, 965 a-Bungarotoxin, 1, 283 in rat uterus, 976 C in rat parotid, 1048 in rat ovary, 1024 Caffeine, 400, 662 in guinea pig heart, 1033 Calcium, in rat brain, 1170 role in brain phenothiazine binding, 690 a-Adrenergic receptor, 304 role in norepinephrine release, 746 in uterine smooth muscle, 304 activation protein kinase, 965 in rat brain, 454 and adenylate cyclase, 1048 in rat heart, 965 Carbachol, 242, 330, 1048

1195 Copyright C 1977 by Academic Press, Inc. IS5N 0026-895X All rights of reproduction in any form reserved. 1196 SUBJECT INDEX

Catalase, 269 Dibucaine, 840 Catechol-O-methyltransferase, 368 Dicumarol, 38 Cerulein, 852 cyclic nucleotide phosphodiesterase, 38 2-Chloroadenosine, 400, 662 Dihydroalprenolol, 291, 314 Chioroquine, 99 Dihydro-fJ-erythroidine, 283 transport in rat retina, 99 Dihydroergocryptine, 304 Chlorpromazine, Dihydroergotanine, 1060 interaction with phospholipids, 474 Dihydrofolate reductase, 1111 Cholecystokinin, 852 7,8-Dihydrofolic acid, 1111 Choleragen, 735 7,8-Dihydropteroylamide, 1111 Cholinergic receptor, 242 Dipyridamole, 400 in astrocytoma cells, 242 Dithiothreitol, 291, 304 in rat parotid, 1048 DNA nucleotidyltransferase, Chioramphenicol, 504 in rat thymus and spleen, 122 Chlorphenoxyisobutyrate, 224 DNA polymerases, 122, 504 Clonidine, a in rat thymus and spleen, 122 a-adrenergic receptor, 454 in rat thymus and spleen, 122 Cocaine, 99 RNA dependent, 496, 585 chloroquine transport, 99 Dopamine, Codeine, methylation, 368 spin-labeled, 766 sensitive adenylate cyclase, 512, 541 Coichicine, 232, 560 receptor in rat brain, 541 Corticosteroid, 426 Dopamine f3-hydroxylase, 362 Cyanide, 185, 269 bovine adrenal medulla, 362 Cyclic nucleotides, 38, 400 in human plasma, 652 in human lung tissue, 38 turnover in rat serums, 956 8-bromo, 330 Doxantrazole, 38 Cyclic nucleotide phosphodiesterase, 38, 330 cyclic nucleotide phosphodiesterase, 38 three forms in human platelets, 400 5-Doxylstearic acid, 435 in chick brain, 679 Drug, in bovine brain, 690 protein binding, 70, 224, 387 in rat pineal gland, 735 Cycloheximide, 1024, 1105 E Cyclophosphamide, 122 Echinomycin, 579 Cyproheptadiene, 640 conformation, 579 Cyproheptadine, 512 Electron paramagnetic resonance, Cytochrome b5 60 membrane fluidity, 435 rat kidney cortex, 60 analgesics, 766 fatty acid desaturation, 60 anthracyclines, 901 microsomal, 60, 759 cytochrome P-450 reaction, 993 Cytochrome oxidase, 50 Epinene, 512 rat fetal liver, 50 Epinephrine, 196, 304, 314, 454, 965 biosynthesis, 50 inhibition ofelectron transport, 196 role of heme, 50 Epoxide hydrase, 342, 1116 Cytochrome P-420, 1092 Ethanol, CytochromeP-448, 259, 819, 1116 membrane fluidity, 435 Cytochrome P-450, 15, 259, 415, 521, 625, 634, 698, Ethidium bromide, 759, 819, 911, 993, 1092 RNA polymerase inhibition, 706 Cytochrome reductase, 60, 196, 415 7-Ethoxycoumarin, 521, 911 Cytosine arabinoside, 122 Ethylene glycol bis(f3-aminoethyl ether)-N,N’-tet- D raacetic acid (EGTA), 44 N-Ethylmaleimide, 291 Daunorubicin, 901 Ethylmorphine N-demethylase, 1092 Deoxyribonucleic acid, metronidazole binding, 872 F Deoxythymidine kinase, 980 Desmethylimipramine, 746 Fatty acid, Dexamethasone, 122 binding to albumin, 224 DNA polymerases, 122 Ferritin, 89 SUBJECT INDEX 1197

5-Fluorouracil, Interferon, DNA polymerases, 122 induction, 374, 488 Fluorescence Iodohydroxybenzylpindolol, 776, 786, 1170 phospholipid, opiate binding, 251 lonophores, fatty acid, albumin binding, 987 A-23187, 330, 746, 1159 2-Fluorohistidine, 1105 3-Isobutyl-1-methylxanthine, 38, 640, 662 Flupenthixol, 216, 512, 541 cyclic nucleotide phosphodiesterase, 38, 735, 965, Fluphenazine, 216 1159 Folic acid, 1126 Isoproterenol, 242, 291, 314, 454, 679, 786, 976, 1033, 2-Formylpyridine thiosemicarbazone, 89 1048, 1060, 1159 copper complex, 89 iron complex, 89 L zinc complex, 89 Levorphanol, 251 fluorescence polarization, 251 G Lidocaine, 242 Gallamine, 283 Linoleic acid hydroperoxide, General anesthetics, 31 cytochrome P-450 destruction, 415 molecular connectivity, 31 Liposomes, 474 structure-activity relationship, 31 Loperaminde, and synaptic transmission, 548 opiate receptor binding, 533 y-Glutamyl carboxypeptidase, 1126 Luteinizing hormone Glutathione, 805 regulation of receptors, 1024 insulin secretion, 598 Lysophosphatidylcholine acyltransferase, 1086 cytochrome reduction, 625 Glycogen phosphorylase, M rat heart, 965 Maleic anhydride, C-6 astrocytoma cells, 1159 platelet aggregation, 407 rat fat cells, 1060 Mersalyl, 1092 Glycogen synthetase, 1060 Metaraminol, 1076 Guanosine 3’,5’-monophosphate, 38, 330, 400, 735, Methotrexate, 80 965, 1048 albumin complex, 80 Guanosine-5’-triphosphate, 512, 560, 786, 1024 aminoethyldextran complex, 80 Guanylate cyclase, 330 Methoxamine, 1060 in tracheal smooth muscle, 330 Metronidazole, 872 5’-Guanylimidodiphosphate, 291, 314, 512, 786, 976, 3-Methylcholanthrene, 185, 259, 342, 415, 521, 625, 1024, 1033 819, 924, 1181 H Methysergide, 640 L-Mimosine, 362 Halothane, 976 Molecular connectivity, 31 Hemoglobin, 15, 89, 832 general anesthetics, 31 Hemoprotein, 15, 50, 759 Monoamine oxidase, plus substrate complex, 15 fluorescent labeling, 726 in hepatic microsomes, 415, 521 labeling, 1005 Hexamethonium bromide, 242 Morphine, 640 Histamine, 330, 679 opiate receptor binding, 533 Human chorionic gonadotropin, 1024 spin labeled, 766 Human serum albumin, 70 Myoglobin, 15 phenprocoumon binding, 70 warfarin binding, 70, 987 N salicylate binding, 387 binding site, 987 Naloxone, Hycanthone methanesulfonate, 719 opiate receptor binding, 533 Hydroxybenzylpindolol, 1159 /3-Naphthoflavone, 259 6-Hydroxydopamine, 454, 679, 796, 805, 1170 Neuromuscular blocking agent, 1 p-Hydroxymercuribenzoate, 291, 304 Nicotine, 283 Nitrobenzylthioinosine, 883, 1014, 1147 p-Nitrophenyl phosphatase, 216 Insulin, K-dependent, 142 secretion, 598 solvent effect, 142 1198 SUBJECT INDEX

Norepinephrine, 172, 314, 454, 735, 805, 1048 Pregnenolone-16a-carbonitrile, 819 mechanism of release, 746, 1060, 1170 Propranolol, 291, 330, 474, 526, 679, 786, 965, 976, Normetanephrine, 172 1060, 1076, 1159 Nuclear magnetic resonance, 15, 113 Prostaglandin E,, 242, 330, 976, 1024, 1159 xylidence + hemoproteins, 15 Prostaglandin F2,,, 330 relaxation time, 15 Prostaglandin synthase, 407 fluorine, 113 acetylation, 407 halothane + phospholipid, 113 Protein kinase, catecholamine interaction with phosphate, 615 rat heart, 965 acetylcholine, 621 Pteroylglutamate, 1126 neuroleptics, 892 Pyridine nucleotides, 185

0 Q

Octopamine, 172, 512 Quinacrine, 99 Opiate receptor, chloroquine transport, 99 in guinea pig brain, 533 Ouabain, 99, 161, 735 R chioroquin transport, 99 Reserpine, 679, 746, 965, 1076 bound to HeLa cells, 161 Reverse transcriptase, 496, 585 metabolism, 161 Ribonucleoside diphosphate reductase, 89 binding to microsomes, 796 RNA polymerase, Oxidases, DNA dependent, 426, 706 flavin-linked inactivation, 378 I, II, and III, 426 Oxytocin, 671 uterine contraction, 671 S

Salbutamol, 1159 P Saxitoxin, 1136 Papavarine, 38, 400 Serotonin, 181, 330, 512 cyclic nucleotide phospodiesterase, 38, 400 amino acid metabolism, 640 Perhydro-histrionicotoxin, 1 Serotonin N-acetyltransferase, Phenacetin, 625 rat pineal gland, 735 Phenanthridines, Serum albumin, RNA polymerase inhibition, 706 human, 70, 387, 987 Phenobarbital, 185, 342, 415, 426, 521, 625, 698, 819, bovine, 80, 224, 872 911, 924 murine, 80 Phenoxybenzamine, 304, 1060 fatty acid binding, 224, 987 Phentolamine, 242, 304, 514, 965, 1060 Slaframine, 185 Phenyldiazine, 832 microsomal oxidation, 185 Phenylephrine, 965, 1060 Steroids, 150 Phenylethanolamine N-methyltransferase, 172 amino acid transport in fibroblasts, 150 effects of Na on activity, 172 Structure activity relationships /3-Phenylethylamine, 746 S-adenosyl-L-homocysteine hydrolase, 939 Phenylhydrazine hydrochloride, 775, 832 ansamycins, 496 Phosphatidyl serine, 251 antischistosomal agents, 719 Phospholipase A, 1033 aryihydrocarbon hydroxylase, 634, 911, 1181 Phospholipid, benzo[a]pyrene, 1116 opiate binding, 251 chloramphenicols, 504 transition temperature, 474 chlorpromazines, 1076 Photoaffinity label, colchicines, 232 for peptide secretagogues, 852 epoxide hydrase, 342 Podophylotoxin, 232, 560 general anesthetics, 31, 548 Polyhalogenated methanes, glucocorticoids, 948 cytochrome P-450 complex, 698 6-hydroxydopamine, 805 Polyribonucleotides, 374, 585 induction of aryl hydrocarbon hydroxylase, 939 strandedness in inhibition of RNA tumor virus, local anesthetics, 840 374 neuroleptics, 892 entrapment within phospholipid vesicles, 488 nitrobenzenes, 269 Practolol, 474 phenanthridines, 706 SUBJECT INDEX 1199

phenylhydrazine, 832 d-Tubocurarine, 1, 283 polynibonucleotides, 374 Tubulin, 232 thalidomides, 133 colchicine, podophyllotoxin binding, 232, 560 thyrotropin releasing factor, 606 mouse brain, 232 uridine uptake (HeLa cells), 1014 rat brain, 560 Suicide substrates, 378 picropodophyllin, lumicolchicine binding, 560 Superoxide dismutase, 196, 269, 832 p-Tyramine, 746 Tyrosinase, 362 T from mouse melanoma, 362 Terminal deoxynucleotidyl transferase, Tyrosine hydroxylase, 44 in rat thymus spleen, 122 role of calcium, 44 Tetracaine, 840 rat striatum, hypothalamus adrenal glands, 44 Tetraethylammoniuzn chloride, 242 -Tetrahydrocannabinol, 864, 1086 U Tetrahydronaphthalimides, 133 Uridine, embryotoxic, 133 uptake in HeLa cells, 1014 teratogenic, 133 Uroporphyrinogen I synthetase, 1126 Tetrodotoxin, 640 Theophylline, 38, 400, 640, 662 V cyclic nucleotide phosphodiesterase, 38, 400 Vinblastine, 560 Thiourea, 242, 840 Vincristine, Thyrotrophin-releasing factor, DNA polymerase, 122 receptor specificity, 606 Vinyl chloride, 993 a-Tocopherol, 901 Trifluoperazine, X phosphodiesterase activator, 690 Triton X-100, X-ray photoelectron spectroscopy, 892 GABA receptor, 442 X-ray structure, S-Tubercidinylhomocysteine, 368 thalidomides, 133