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S1 Guidelines “Lumbar Puncture and Cerebrospinal Fluid Analysis” (Abridged and Translated Version) H

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S1 Guidelines “Lumbar Puncture and Cerebrospinal Fluid Analysis” (Abridged and Translated Version) H Tumani et al. Neurological Research and Practice (2020) 2:8 Neurological Research https://doi.org/10.1186/s42466-020-0051-z and Practice GUIDELINES Open Access S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version) H. Tumani1,2* , H. F. Petereit3, A. Gerritzen4, C. C. Gross5, A. Huss6, S. Isenmann7, S. Jesse6, M. Khalil8, P. Lewczuk9, J. Lewerenz6, F. Leypoldt10, N. Melzer5, S. G. Meuth5, M. Otto6, K. Ruprecht11, E. Sindern12, A. Spreer13, M. Stangel14, H. Strik15, M. Uhr16, J. Vogelgsang17, K.-P. Wandinger18, T. Weber19, M. Wick20, B. Wildemann21, J. Wiltfang17, D. Woitalla22, I. Zerr23 and T. Zimmermann24 Abstract Introduction: Cerebrospinal fluid (CSF) analysis is important for detecting inflammation of the nervous system and the meninges, bleeding in the area of the subarachnoid space that may not be visualized by imaging, and the spread of malignant diseases to the CSF space. In the diagnosis and differential diagnosis of neurodegenerative diseases, the importance of CSF analysis is increasing. Measuring the opening pressure of CSF in idiopathic intracranial hypertension and at spinal tap in normal pressure hydrocephalus constitute diagnostic examination procedures with therapeutic benefits. Recommendations (most important 3-5 recommendations on a glimpse): 1. The indications and contraindications must be checked before lumbar puncture (LP) is performed, and sampling CSF requires the consent of the patient. 2. Puncture with an atraumatic needle is associated with a lower incidence of postpuncture discomfort. The frequency of postpuncture syndrome correlates inversely with age and body mass index, and it is more common in women and patients with a history of headache. The sharp needle is preferably used in older or obese patients, also in punctures expected to be difficult. 3. In order to avoid repeating LP, a sufficient quantity of CSF (at least 10 ml) should be collected. The CSF sample and the serum sample taken at the same time should be sent to a specialized laboratory immediately so that the emergency and basic CSF analysis program can be carried out within 2 h. 4. The indication for LP in anticoagulant therapy should always be decided on an individual basis. The risk of interrupting anticoagulant therapy must be weighed against the increased bleeding risk of LP with anticoagulant therapy. 5. As a quality assurance measure in CSF analysis, it is recommended that all cytological, clinical-chemical, and microbiological findings are combined in an integrated summary report and evaluated by an expert in CSF analysis. (Continued on next page) * Correspondence: [email protected] This article has been published in German language and is available online at: Tumani, H., Petereit, H.F., Gerritzen, A. et al. S1-Leitlinie: Lumbalpunktion und Liquordiagnostik. DGNeurologie 2, 456–480 (2019). https://doi.org/ 10.1007/s42451-019-00126-z 1Fachklinik für Neurologie Dietenbronn, Dietenbronn 7, 88477 Schwendi, Germany 2Neurologische Uniklinik im RKU, Universitätsklinikum Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Tumani et al. Neurological Research and Practice (2020) 2:8 Page 2 of 28 (Continued from previous page) Conclusions: In view of the importance and developments in CSF analysis, the S1 guideline “Lumbar puncture and cerebrospinal fluid analysis” was recently prepared by the German Society for CSF analysis and clinical neurochemistry (DGLN) and published in German in accordance with the guidelines of the AWMF (https://www.awmf.org). /uploads/tx_ szleitlinien/030-141l_S1_Lumbalpunktion_und_Liquordiagnostik_2019-08.pdf). The present article is an abridged translation of the above cited guideline. The guideline has been jointly edited by the DGLN and DGN. Introduction The removal of CSF in cases of increased cerebrospinal The present article is an abridged translation of the guideline pressure can lead to an entrapment of neuronal structures recently published online (https://www.awmf.org/uploads/ due to axial displacement of the brain and may be fatal. tx_szleitlinien/030-141l_S1_Lumbalpunktion_und_Liquor- Examination of the ocular fundus by ophtalmoscopy is diagnostik_2019-08.pdf). This guideline contains basic rec- less sensitive than cross-sectional imaging as a congestive ommendations concerning practical procedures for CSF papilla may be absent despite increased intracranial pres- space puncture, in particular with regard to indications and sure. The presence of a congestive papilla in the case of possible contraindications, information and consent, selec- idiopathic intracranial hypertension does not represent a tion of the puncture needle, procedure in patients treated contraindication for a relief puncture. with anticoagulants, and thrombocytic function inhibitors, sample collection, treatment, and analysis as well as for com- piling findings. The long version deals in detail with individ- Tendency to bleed ual clinical presentations which had to be shortened for A platelet count below 50,000/μL, a quick test below 50%, reasons of space in the present guideline. The structure, table an INR of more than 1.8, and a clearly pathologically acti- of contents, and basic features are presented here. vated partial thromboplastin time (aPTT) are considered contraindications for LP. When in doubt, the platelet ag- gregation time can be determined by apparatus or the Diagnostic lumbar puncture Indications Apart from a brain biopsy, CSF analysis is the only proced- ure that can detect inflammation in the CSF or the central Table 1 Indications for the diagnostic LP under consideration of the contraindications (see below) nervous system. Therefore, meningitis, encephalitis, myelitis, radiculitis, and (poly)neuritis in acute or chronic form consti- Suspected condition tute core indications for lumbar puncture (LP) (Table 1). …Meningitis CSF analysis is playing an increasingly important role in neu- …Encephalitis rodegenerative diseases, especially for dementia and differen- …Myelitis tial diagnoses. Detecting malignant cells in the CSF confirms …Neuroborreliosis the diagnosis of a meningeosis carcinomatosa or lymphoma- …Neurotuberculosis tosa. The detection of blood and its degradation products in the CSF can confirm the diagnosis of subarachnoid ...Polyradiculoneuritis Guillain-Barré hemorrhage even if the diagnosis cannot be made by cranial …Chronic inflammatory demyelinating polyneuropathy CT. LPs for relief in normal pressure hydrocephalus or idio- …Encephalomyelitis disseminata pathic intracranial hypertension represent a special case. In …Neuromyelitis optica spectrum disorder children under 18 years of age, fever of unknown cause was …Neurosarcoidosis the most frequent indication for LP at 20%, in adult patients …Neurolupus headache at 39% [45, 179]. …Subarachnoidal hemorrhage …Meningiosis carcinomatosa Contraindications …Meningiosis lymphomatosa Increased intracranial pressure Before electively collecting CSF, the presence of clinical ...Idiopathic intracranial hypertension CSF pressure signs must be ruled out. Cranial imaging ...Normal pressure hydrocephalus (CCT, cMRT) prior to LP is needed in special cases (clin- Differential diagnosis of the following core symptoms: ical evidence of increased cerebral pressure, focal neuro- -Headache logical deficits, first epileptic seizure, vigilance disorder, or -Dementia syndrome history of immunosuppression), but is not necessary in -Sepsis with unknown focus of infection the absence of clinical signs of increased cerebral pressure. Tumani et al. Neurological Research and Practice (2020) 2:8 Page 3 of 28 bleeding time can be clinically determined by a scratch Andexanet alfa has already been approved and is avail- test. able as an antidote for bleeding caused by Factor Xa in- Thrombopenia below 50,000/μL is a relative contra- hibitors. Approval was granted in the first half of 2019 indication and thrombopenia below 10,000/μL an abso- in Germany. If discontinuation of NOAK is associated lute contraindication. In the case of thrombocyte counts with increased thromboembolic risk, conversion to hep- below 10,000/μL, thrombocytes should always be arin (bridging) is recommended [39, 111]. substituted prior to LP. In the range between 10,000 and A case of a bleeding complication after LP under a 50,000/μL an increased complication rate is to be ex- double platelet inhibition with ASS (acetylsalicylic acid) pected. The decision for thrombocyte substitution must and clopidogrel has been reported [137]. Systematic stud- be made individually. ies on the frequency of bleeding complications after LP in Therapeutically induced coagulation disorders should patients with dual thrombocyte aggregation inhibition - if medically justifiable - be stopped before the proced- (dTAH) are missing, however. For individuals with dTAH ure, and their effect should be eliminated by medication and
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