DOCSLIB.ORG

Contribution À L'étude De L'activité Pharmacologique De Terminalia

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Contribution À L'étude De L'activité Pharmacologique De Terminalia Contribution à l’étude de l’activité pharmacologique de Terminalia macroptera Guill.et Perr. (Combretaceae) dans le but de l’élaboration d’un médicament traditionnel amélioré au Mali (Afrique de l’Ouest) Mahamane Haïdara To cite this version: Mahamane Haïdara. Contribution à l’étude de l’activité pharmacologique de Terminalia macroptera Guill.et Perr. (Combretaceae) dans le but de l’élaboration d’un médicament traditionnel amélioré au Mali (Afrique de l’Ouest). Pharmacologie. Université Paul Sabatier - Toulouse III, 2018. Français. NNT : 2018TOU30027. tel-02068818 HAL Id: tel-02068818 https://tel.archives-ouvertes.fr/tel-02068818 Submitted on 15 Mar 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. ˲·ª»®­·¬7 ̱«´±«­» í п«´ Í¿¾¿¬·»® øËÌí п«´ Í¿¾¿¬·»®÷ ݱ¬«¬»´´» ·²¬»®²¿¬·±²¿´» ¿ª»½ þ´ùײ­¬·¬«¬ Í«°7®·»«® ¼» Ú±®³¿¬·±² »¬ ¼» λ½¸»®½¸» ß°°´·¯«7» ø×ÍÚÎß÷ ¼» ´ù˲·ª»®­·¬7 ¼»­ ͽ·»²½»­ Ö«®·¼·¯«»­ »¬ б´·¬·¯«»­ ¼» Þ¿³¿µ±ô Ó¿´·þ Ó¿¸¿³¿²» Øß×ÜßÎß ´» ³»®½®»¼· îï º7ª®·»® îðïè ݱ²¬®·¾«¬·±² @ ´Ž7¬«¼» ¼» ´Ž¿½¬·ª·¬7 °¸¿®³¿½±´±¹·¯«» ¼» Ì»®³·²¿´·¿ ³¿½®±°¬»®¿ Ù«·´´ò ú л®®ò øݱ³¾®»¬¿½»¿»÷ ¼¿²­ ´» ¾«¬ ¼» ´ù7´¿¾±®¿¬·±² ¼ù«² ³7¼·½¿³»²¬ ¬®¿¼·¬·±²²»´ ¿³7´·±®7 ¿« Ó¿´· øߺ®·¯«» ¼» ´ŽÑ«»­¬÷ò »¬ ¼·­½·°´·²» ±« ­°7½·¿´·¬7 ÛÜ ÞÍÞ æ и¿®³¿½±´±¹·» ËÓÎ ïëî и¿®³¿óÜ»ªô ×ÎÜóËÐÍô ̱«´±«­»ô Ú®¿²½» ÞÑËÎÜÇ Ù»²»ª·8ª» »¬ ÍßÒÑÙÑ Î±µ·¿ Ö«®§ æ ÞÑËÎÜÇ Ù»²»ª·8ª» ݸ¿®¹7» ¼» λ½¸»®½¸»­ ËÓÎ ïëîô ×ÎÜóËÐÍô ̱«´±«­» Ü·®»½¬®·½» ÍßÒÑÙÑ Î±µ·¿ Ю±º»­­»«® ¼»­ ˲·ª»®­·¬7­ô Þ¿³¿µ± øÓ¿´·÷ ݱóÜ·®»½¬®·½» ÑÔÔ×Ê×ÛÎ Ûª»´§²» Ю±º»­­»«® ¼»­ ˲·ª»®­·¬7­ô Ó¿®­»·´´» ο°°±®¬»«® ÎÑËÓÇ Ê·²½»²¬ Ó¿2¬®» ¼» ݱ²º7®»²½»­ ¼»­ ˲·ª»®­·¬7­ô Ô·´´» ο°°±®¬»«® ØßÜÜßÜ Ó±¸¿³»¼ ݸ¿®¹7 ¼» λ½¸»®½¸»­ ËÓÎ ïëîô ×ÎÜóËÐÍô ̱«´±«­» Û¨¿³·²¿¬»«® ÚßÞÎÛ Ò·½±´¿­ Ю±º»­­»«® ¼»­ ˲·ª»®­·¬7­ô ̱«´±«­» Ю7­·¼»²¬ Contribution à l’étude de l’activité pharmacologique de Terminalia macroptera Guill. & Perr. (Combretaceae) dans le but de l'élaboration d'un médicament traditionnel amélioré au Mali (Afrique de l’Ouest). Présentée par Mahamane HAIDARA Directrice de thèse : Geneviève BOURDY Co-directrice de thèse : Rokia SANOGO Unité de recherche : UMR 152 Pharma-Dev, Université Paul Sabatier, Institut de Recherche pour le Développement, Toulouse, France Ecole doctorale : BSB (Biologie, Santé, Biotechnologies) Soutenance prévue le 21 février 2018 DEDICACES A ALLAH Je rends grâce à ALLAH, le Créateur, le Tout puissant, le Tout Miséricordieux, le Très Miséricordieux. Merci de m’avoir donné la vie, la santé, la force, la patience, la volonté et l’opportunité d’être instruit. ….Ce que ALLAHaccorde en miséricorde aux gens, il n’est personne à pouvoir le retenir. Et ce qu’il retient, il n’est personne à le relâcher après Lui. Et c’est Lui le Puissant, le Sage… (Sourate 35 : le créateur, verset 2). A mes parents : Almoukoutar et Seynabou N’DIAYE Je ne pourrai jamais assez vous dire merci pour les conseils, le soutien, les encouragements et pour les prières qui m’ont accompagnés tout au long de mes études. Ce travail est le fruit de tous vos sacrifices, qui mieux que des mots, traduit tout l’amour que je ressens pour vous. Que Dieu vous garde longtemps près de nous. A ma très chère épouse Zeinabou Alassane KONE pour ta patience, ton soutien et ton amour durant cette longue et difficile épreuve, et à mes enfantsTènin Mahamane, Khadidiatou Mahamane et Almoukoutar. Sachez que je vous aime profondément, que Allah, le Clément, le Miséricordieux bénisse notre famille. A mon frère et à mes sœurs : Mahalmoudou, N’Deye Mariam, Djeinabou et Ramata Ce travail est aussi le vôtre car sans votre soutien, vos encouragements et vos conseils il n’aurait pas pu voir le jour. A mes grands-parents Mahamane Haїdara, Maria Haїdara, Mahalmoudou Haїdara, Oumar N’Diaye, Emilie Konaté (in memoriam) Ce travail vous est dédié.Malgré votre absence vous resterez présents en nous et cela pour toujours. REMERCIEMENTS Monsieur le Professeur Nicolas FABRE, Merci de nous avoir accueillis comme doctorant dans le laboratoirePharma-Dev de Toulouse et d’avoir accepté de juger ce travail de thèse. Madame le Docteur Geneviève BOURDY (Directrice de thèse) et Mme le Professeur Rokia SANOGO ( Co-Directrice) Permettez-nous de vous adresser nos remerciements pour l’honneur que vous nous avez fait ennous guidant dans la réalisation de ce travail. Nous avons été heureux de travailler sous votredirection.Vous avez fait preuve de patience et de disponibilité à notre égard.Grâce à vous nous avons pu acquerir la rigueur dans la démarche scientifique.Puissiez-vous trouver ici le témoignage de notre reconnaissance la plus sincère. Madame le Professeur Evelyne OLLIVIER et Monsieur le Docteur Vincent ROUMY Merci de nous avoir fait l’honneur d’ête les rapporteurs et de siéger dans le jury de cette thèse. Monsieur le Docteur Mohamed HADDAD Nous avons été très touchés par votre accueil et la disponibilité dont vous avez fait preuve à notreégard. A travers ce travail, recevez notre profonde gratitude. Madame le Professeur Myriam MARTINO et Madame le Professeur Françoise BENOIT-VICAL (Membre du comité de suivi de la thèse) Merci pour vos conseils. Vos critiques constructives nous ont permis d’avancer avec profit dans ce travail de thèse. Madame le Professeur émériteIsabelle FOURASTE Merci pour vos conseils et votre contribution dans la réalisation des essais de contrôle botanique. Monsieur le Professeur Drissa DIALLO Merci pour vos conseils et pour votre soutien. Madame le Docteur Agnès AUBOUY Merci pour votre contribution dans la réalisation du test antiplasmodial in vivo. Monsieur le Docteur Guillaume MARTI Merci pour votre contribution dans la réalisation de la déréplication. Monsieur le Docteur Eric DEHARO Merci pour vos conseils. Monsieur le Docteur Sergio GIANI Merci pour vos conseils et pour votre soutien. Madame le Docteur Nah TRAORE et Monsieur le Docteur Aimé SOMBORO Merci pour vos conseils et votre soutien. Madame l’Ingénieure Sandra BOURGEADE-DELMAS Merci pour votre contribution dans la réalisation du test antiplasmodial in vitro. Mesdames et Messieurs les Docteurs Marie Nyoni SOGOBA, Fatoumata KANADJIGUI, Adama DENOU, Amadou DIAKITE, Salia DIARRA, Aboubacar NIARE, Birama DIARRA, Merci pour vos conseils, votre soutien et pour l’aide apportée pour la réalisation des travaux au sein du laboratoire du Département de Médecine Traditionnelle de Bamako, Mali. Monsieur le Techniciendes Eaux et des Forêts N’golo BALLO, Merci pour votre soutien dans la réalisation de l’enquête auprès des tradipraticiens-herboristes et dans la récolte des espèces. Dr André Tibiri † Merci pour sa contribution dans l’analyse statistique des données pharmacologiques Monsieur les Techniciens Kassim COULIBALY, Fagnan SANOGO, Merci pour l’aide apportée pour la réalisation des travaux de laboratoire au sein du Département de Médecine Traditionnelle de Bamako, Mali. Monsieur l’Ingénieur des Eaux et Forêts Seydou DEMBELE, Merci de nous avoir aidés pour l’identification des espèces et la confection des herbiers. Je tiens également à remercier : Institut de Recherche pour le Développement (IRD) et Programme de Formation des Formateurs (PFF)des universités du Mali Je remercie ces deux institutions pour l’aide financière apportée pour la réalisation des travaux de cette thèse. Monsieur Bruno SICARD, Directeur de l’IRD à Bamako et Monsieur Solimane Ag ATTEYNINE. Mes oncles, tantes, cousins, cousines, beaux-frères, belles sœurs, nièces et neveux Mes amis : Soungalo DIARRA, Younouss KEITA, Oumar KANE, Aly DIAKITE, Ibrahim Diomansi DOUMBIA, Dramane SIDIBE, Fousseini KOUYATE, Salif DIARRA, Youba DIARRA, Pascal DIARRA et Tidiane SANGARE. Monsieur le Docteur Amadou Makhan SARR du laboratoire d’analyse biomédical « Biotech »pour son soutien dans la réalisation du dosage des enzymes marqueurs du foie. Monsieur le Docteur Nouhou Madali DIALLO de la Pharmacie « Bazi-Gourma de Kati ». Mme KONE Korotoumou TRAORE. Le personnel du Département de Médecine Traditionnellede Bamako (Mali) pour leur soutien et leur affection. L’ensemble de l’équipe du laboratoire Pharma-Dev pour leur soutien et leur affection. Mes amis pharmaciens et médecins de la Faculté de Médecine de Pharmacie et d’Odonto-Stomatologie de Bamako, (Mali). Sans oublier tous ceux que je n’ai pas cités ! RESUME En Afrique, la valorisation des pharmacopées traditionnelles constitue bien souvent un moyen d’orienter la recherche vers de nouveaux antipaludéens. Les plantes médicinales antipaludiques peuvent servir de base à la formulation de Médicaments Traditionnels Améliorés (MTA) ou être source de nouvelles molécules antiplasmodiales. Sur la base d'une recherche bibliographique exhaustive, 10 plantes médicinales largement utilisées au Mali dans le traitement du paludisme et des affections hépatiques (ictères) ont été sélectionnées par une approche d'ethnopharmacologie quantitative et évaluées in vitro sur Plasmodium falciparum FcB1, conduisant à la sélection de Terminalia macroptera (Feuilles et Racines). Terminalia macroptera est une espèce largement utilisée au Mali contre le paludisme, la fièvre, les affections hépatiques (ictères) et la plaie. Dans le contexte de mise sur le marché d'un
Load more

Recommended publications
  • Chemistry and Pharmacology of Kinkéliba (Combretum
    CHEMISTRY AND PHARMACOLOGY OF KINKÉLIBA (COMBRETUM MICRANTHUM), A WEST AFRICAN MEDICINAL PLANT By CARA RENAE WELCH A Dissertation submitted to the Graduate School-New Brunswick Rutgers, The State University of New Jersey in partial fulfillment of the requirements for the degree of Doctor of Philosophy Graduate Program in Medicinal Chemistry written under the direction of Dr. James E. Simon and approved by ______________________________ ______________________________ ______________________________ ______________________________ New Brunswick, New Jersey January, 2010 ABSTRACT OF THE DISSERTATION Chemistry and Pharmacology of Kinkéliba (Combretum micranthum), a West African Medicinal Plant by CARA RENAE WELCH Dissertation Director: James E. Simon Kinkéliba (Combretum micranthum, Fam. Combretaceae) is an undomesticated shrub species of western Africa and is one of the most popular traditional bush teas of Senegal. The herbal beverage is traditionally used for weight loss, digestion, as a diuretic and mild antibiotic, and to relieve pain. The fresh leaves are used to treat malarial fever. Leaf extracts, the most biologically active plant tissue relative to stem, bark and roots, were screened for antioxidant capacity, measuring the removal of a radical by UV/VIS spectrophotometry, anti-inflammatory activity, measuring inducible nitric oxide synthase (iNOS) in RAW 264.7 macrophage cells, and glucose-lowering activity, measuring phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression in an H4IIE rat hepatoma cell line. Radical oxygen scavenging activity, or antioxidant capacity, was utilized for initially directing the fractionation; highlighted subfractions and isolated compounds were subsequently tested for anti-inflammatory and glucose-lowering activities. The ethyl acetate and n-butanol fractions of the crude leaf extract were fractionated leading to the isolation and identification of a number of polyphenolic ii compounds.
    [Show full text]
  • Inhibitory Activities of Selected Sudanese Medicinal Plants On
    Mohieldin et al. BMC Complementary and Alternative Medicine (2017) 17:224 DOI 10.1186/s12906-017-1735-y RESEARCH ARTICLE Open Access Inhibitory activities of selected Sudanese medicinal plants on Porphyromonas gingivalis and matrix metalloproteinase-9 and isolation of bioactive compounds from Combretum hartmannianum (Schweinf) bark Ebtihal Abdalla M. Mohieldin1,2, Ali Mahmoud Muddathir3* and Tohru Mitsunaga2 Abstract Background: Periodontal diseases are one of the major health problems and among the most important preventable global infectious diseases. Porphyromonas gingivalis is an anaerobic Gram-negative bacterium which has been strongly implicated in the etiology of periodontitis. Additionally, matrix metalloproteinases-9 (MMP-9) is an important factor contributing to periodontal tissue destruction by a variety of mechanisms. The purpose of this study was to evaluate the selected Sudanese medicinal plants against P. gingivalis bacteria and their inhibitory activities on MMP-9. Methods: Sixty two methanolic and 50% ethanolic extracts from 24 plants species were tested for antibacterial activity against P. gingivalis using microplate dilution assay method to determine the minimum inhibitory concentration (MIC). The inhibitory activity of seven methanol extracts selected from the 62 extracts against MMP-9 was determined by Colorimetric Drug Discovery Kit. In search of bioactive lead compounds, Combretum hartmannianum bark which was found to be within the most active plant extracts was subjected to various chromatographic (medium pressure liquid chromatography, column chromatography on a Sephadex LH-20, preparative high performance liquid chromatography) and spectroscopic methods (liquid chromatography-mass spectrometry, Nuclear Magnetic Resonance (NMR)) to isolate and characterize flavogalonic acid dilactone and terchebulin as bioactive compounds. Results: About 80% of the crude extracts provided a MIC value ≤4 mg/ml against bacteria.
    [Show full text]
  • Isolation of Ellagitannin Monomer and Macrocyclic Dimer from Castanopsis Carlesii Leaves
    HETEROCYCLES, Vol. 86, No. 1, 2012 381 HETEROCYCLES, Vol. 86, No. 1, 2012, pp. 381 - 389. © 2012 The Japan Institute of Heterocyclic Chemistry Received, 9th June, 2012, Accepted, 20th July, 2012, Published online, 24th July, 2012 DOI: 10.3987/COM-12-S(N)29 ISOLATION OF ELLAGITANNIN MONOMER AND MACROCYCLIC DIMER FROM CASTANOPSIS CARLESII LEAVES Yong-Lin Huang,a,b Takashi Tanaka,*,a Yosuke Matsuo,a Isao Kouno,a Dian-Peng Li,b and Gen-ichiro Nonakac aGraduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-Machi, Nagasaki 852-8521, Japan; [email protected] bGuangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guilin 541006, China c Usaien Pharmaceutical Company, Ltd., 1-4-6 Zaimoku, Saga 840-0055, Japan Abstract – In a phytochemical and chemotaxonomical investigation of Castanopsis species (Fagaceae), new monomeric and dimeric ellagitannins, named carlesiins A (1) and B (2), were isolated from fresh leaves of Castanopsis carlesii along with 55 known compounds. Carlesiin A was identified as 1-O-galloyl-4,6-(S)-tergalloyl-β-D-glucose. Carlesiin B is a macrocyclic ellagitannin dimer with a symmetrical structure composed of two tergalloyl and two glucopyranose moieties. Their structures were elucidated based on spectroscopic and chemical evidence. INTRODUCTION The species in the Castanopsis (Fagaceae) genus are evergreen trees that are found in East Asia, sometimes as the dominant species in a forest. These trees are often used as forestry or ornamental trees, and the wood is an important construction material. There are about 120 species in the genus, but the chemical compositions of only a few species have been studied.
    [Show full text]
  • Print This Article
    PEER-REVIEWED ARTICLE bioresources.com Analysis of Valonia Oak (Quercus aegylops) Acorn Tannin and Wood Adhesives Application Soliman Abdalla,a,* Antonio Pizzi,a,b,* Fatimah Bahabri,c and Aysha Ganash d The coupling of matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) mass spectrometry with 13C nuclear magnetic resonance (NMR) is a suitable method for examining the composition of hydrolysable tannins and has been applied to the investigation of valonia oak (Quercus aegylops) acorn tannin extract. Such methods can determine the extract’s structural aspects and other characteristics. It was determined that valonia oak acorn tannin extract is composed of mainly pentagalloylglucose structures; their rearrangement structures, vescalagin/castalagin (with linkages to flavogallonic acid) and vescalin/castalin; ellagic acid and vescavaloneic/castavaloneic acid; and free gallic acid and glucose. Traces of catechin gallate were also observed in this tannin extract. The tannin from acorns of valonia oak was used to substitute up to 50% of the phenol used in the preparation of phenolic resins as adhesives for wood particleboard. These phenol-tannin-formaldehyde resins showed comparable performance to phenol-formaldehyde resins. Keywords: MALDI; Mass spectrometry; 13C NMR; Hydrolysable tannins; Structure; Structural composition; Oligomer distribution; Wood panels; Phenolic adhesives Contact information: a: Department of Physics, Faculty of Science, King Abdulaziz University Jeddah, P.O. Box 80203, Jeddah 21589, Saudi Arabia; b:
    [Show full text]
  • Growing Naturally in Sudan No
    50 REPORTS FORESTRY TROPICAL UNIVERSITY OF HELSINKI UNIVERSITY OF HELSINKI Viikki Tropical Resources Institute Viikki Tropical Resources Institute VITRI UNIVERSITYVITRI OF HELSINKI Viikki Tropical Resources Institute TROPICAL FORESTRY REPORTS VITRI TROPICAL FORESTRY REPORTS No.No. 37 32 Husgafvel,Laxén, J. 2007.R. 2010. Is prosopis Global aand curse EU or governance a blessing? for– An sustainable ecological-economic forest management with special TROPICAL FORESTRY REPORTS referenceanalysis to of capacity an invasive building alien in tree Ethiopi speciesa and in SouthernSudan. Doctoral Sudan. thesis.Doctoral thesis. 34 No.No. 38 33 Walter,Katila, K. P. 2011. 2008. Prosopis, Devolution an alienof forest-related among the sacred rights: trees Comparative of South analysesIndia. Doctoral of six developing thesis. 50 No. 39 Kalame,countries. F.B. Doctoral2011. Forest thesis. governance and climate change adaptation: Case studies of four African No. 34 countries.Reyes, T.Doctoral 2008. Agroforestry thesis. systems for sustainable livelihoods and improved Ethnobotan No. 40 Paavola,land management M. 2012. The in impact the East of villageUsambara development Mountains, funds Tanzania. on community Doctoral welfare thesis. in the Lao People’s and No. 35 DemocraticZhou, P. 2008.Republic. Landscape-scale Doctoral thesis. soil erosion modelling and ecological restoration for a Anogeissus No. 41 Omoro,mountainous Loice M.A. watershed 2012. Impacts in Sichuan, of indigenous China. Doctoral and exotic thesis. tree species on ecosystem services: Case No. 36 studyHares, on the M. mountain& Luukkanen, cloud O. forests 2008. ofResearch Taita Hills, Collaboration Kenya. Doctoral on Responsible thesis. Natural Resource No. 42 Alam,Management, S.A. 2013. TheCarbon 1st UniPID stocks, Workshop.
    [Show full text]
  • Molecular Investigation of Valonea Tannin
    Molecular investigation of valonea tannin by Hasan ÖZGÜNAY Özcan SARI Ege University Faculty of Engineering Department of Leather Engineering 35100 Bornova-İZMİR - TÜRKİYE and Murat TOZAN TFL Deri Teknolojisi San. ve Tic. A. S. 34957 Tuzla-ISTANBUL-TÜRKİYE ABSTRACT Valonea is one of the well-known vegetable tannins, have been used for tannage and retannage processes in leather making. Besides being used very extensively in leather industry, its main components and chemical structure is gradually identified. In order to investigate the chemical structure of valonea with novel techniques, MALDI-TOF (Matrix- Assisted Laser Desorption/Ionisation Time-of-Flight) and FTIR (Fourier Transform Infrared) Spectroscopy were used. MALDI-TOF spectrum showed the presence of low molecular weight fraction of hydrolysable tannins like nonahydroxytriphnoic, flavogallonic acid, ellagic and gallic acid, pentagalloylglucose and all sorts of degradation and oxidation products are thought to be major components of valonea tannin. Moreover, castalagin/vescalagin and ones added by a few residual structures/atoms in this way having larger molecule and bigger mass than castalagin/vescalagin, derived by internal rearragements of a larger molecule are major components of valonea. From the FTIR spectrum of valonea, it is detected that valonea has a -1 -1 -1 complex structure having -OH at 3420 cm , C=C at 1610 cm , C=O at 1734 cm , CH2 at 2939 cm-1, C-OH at 1340 cm-1, C-O-C at 1185 cm-1 and ester bonds at 1045 cm-1. INTRODUCTION Leather industry is looking at options for metal-free tanning systems and especially tanning materials based on the natural products such as vegetable tannins are gained importance.
    [Show full text]
  • WO 2018/002916 Al O
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2018/002916 Al 04 January 2018 (04.01.2018) W !P O PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C08F2/32 (2006.01) C08J 9/00 (2006.01) kind of national protection available): AE, AG, AL, AM, C08G 18/08 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, PCT/IL20 17/050706 HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (22) International Filing Date: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 26 June 2017 (26.06.2017) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (26) Publication Language: English TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 246468 26 June 2016 (26.06.2016) IL kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (71) Applicant: TECHNION RESEARCH & DEVEL¬ UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, OPMENT FOUNDATION LIMITED [IL/IL]; Senate TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, House, Technion City, 3200004 Haifa (IL).
    [Show full text]
  • Plantes Médicinales Guinéennes : Validation De L’Effet Antipaludique Et Impact Sur La Modulation De L’Immunité Aïssata Camara
    Plantes médicinales guinéennes : validation de l’effet antipaludique et impact sur la modulation de l’immunité Aïssata Camara To cite this version: Aïssata Camara. Plantes médicinales guinéennes : validation de l’effet antipaludique et impact sur la modulation de l’immunité. Immunologie. Université Paul Sabatier - Toulouse III; Université Gamal Abdel Nasser (Conakry), 2020. Français. NNT : 2020TOU30028. tel-03008482 HAL Id: tel-03008482 https://tel.archives-ouvertes.fr/tel-03008482 Submitted on 16 Nov 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. THÈSE En vue de l’obtention du DOCTORAT DE L’UNIVERSITÉ DE TOULOUSE Délivré par l'Université Toulouse 3 - Paul Sabatier Cotutelle internationale : Université Gamal Abdel Nasser de Conakry Présentée et soutenue par Aissata CAMARA Le 24 juin 2020 Plantes médicinales guinéennes : validation de l'effet antipaludique et impact sur la modulation de l'immunité Ecole doctorale : BSB - Biologie, Santé, Biotechnologies Spécialité : PHARMACOLOGIE Unité de recherche : PHARMA-DEV -Laboratoire Pharmacochimie et Pharmacologie pour le Développement Thèse dirigée par Agnès AUBOUY et Mamadou Aliou BALDE Jury M. Vincent ROUMY, Rapporteur M. David COURTIN, Rapporteur M. Alexis VALENTIN, Examinateur Mme Sandrine HOUZé, Examinatrice Mme Agnès AUBOUY, Directrice de thèse M.
    [Show full text]
  • Characterization of Gum from Anogeissus Leiocarpus توصيف صمغ شجرة الصهب
    Sudan University of Science and Technology Post College of Graduate Studies Characterization of Gum From Anogeissus leiocarpus توصيف صمغ شجرة الصهب A Thesis Submitted in Fulfillment of the Requirement of the Degree of Ph.D. in Chemistry By Muzamil Hassaballa Abd El-Mula (B.Sc., M.Sc., Chemistry) Supervisor Professor: Mohammed El-Mubarak Osman Co-Supervisor Professor: Elfatih Ahamed Hassan Oct., 2018 1 2 3 اﻷستهﻻل سىرح: يىسف اﻵيخ: 76 i Dedication To Souls of my parents, who inspired and encouraged me, through hard times, and to my brothers and sisters. ii Acknowledgements First and foremost, I would like to praise ALLAH who made all things possible... I cannot express gratitude to supervisors professor, Mohammed El-Mubark Osman, and; professor. El-Fatih Ahmed Hassan for their continued support and encour- agement. I offer my sincere appreciation for the learning opportunities provided by them. I would like to thank my classmates, Dr. Mai Makki, Dr. Amira Abd Elaziz; and my children, Doaa, Waed , Shahed, Ahed, Daed and Bassam for moral support. Thanks are due to Mr. Alrasheed Awad Mohammed for technical support, Univer- sity of Khartoum. To my caring, loving, and supportive wife, Nadia Bushra: my deepest gratitude. Your encouragement when the times got rough was much appreciated and duly noted. It was a great comfort and relief to know that you were willing to provide management of our household activities while I completed my work. Special thanks to my Azal Pharma colleagues for their undivided support and interest who inspired and encouraged me to go my own way. Last but not the least I want to thank my friends who appreciated my work and motivated me.
    [Show full text]
  • The Chemistry and Biological Activities of Natural Products from Northern African Plant Families: from Taccaceae to Zygophyllaceae
    Nat. Prod. Bioprospect. (2016) 6:63–96 DOI 10.1007/s13659-016-0091-9 REVIEW The Chemistry and Biological Activities of Natural Products from Northern African Plant Families: From Taccaceae to Zygophyllaceae Fidele Ntie-Kang . Leonel E. Njume . Yvette I. Malange . Stefan Gu¨nther . Wolfgang Sippl . Joseph N. Yong Received: 12 January 2016 / Accepted: 15 February 2016 / Published online: 1 March 2016 Ó The Author(s) 2016. This article is published with open access at Springerlink.com Abstract Traditional medicinal practices have a profound influence on the daily lives of people living in developing countries, particularly in Africa, since the populations cannot generally afford the cost of Western medicines. We have undertaken to investigate the correlation between the uses of plants in Traditional African medicine and the biological activities of the derived natural products, with the aim to validate the use of traditional medicine in Northern African communities. The literature is covered for the period 1959–2015 and part III of this review series focuses on plant families with names beginning with letters T to Z. The authors have focused on curating data from journals in natural products and phytomedicine. Within each journal home page, a query search based on country name was conducted. All articles ‘‘hits’’ were then verified, one at a time, that the species was harvested within the Northern African geographical regions. The current data partly constitutes the bases for the development of the Northern African natural compounds database. The review discusses 284 plant-based natural compounds from 34 species and 11 families. It was observed that the ethnob- otanical uses of less than 40 % of the plant species surveyed correlated with the bioactivities of compounds identified.
    [Show full text]
  • Traditional Applications of Tannin Rich Extracts Supported by Scientific Data: Chemical Composition, Bioavailability and Bioaccessibility
    foods Review Traditional Applications of Tannin Rich Extracts Supported by Scientific Data: Chemical Composition, Bioavailability and Bioaccessibility Maria Fraga-Corral 1,2 , Paz Otero 1,3 , Lucia Cassani 1,4 , Javier Echave 1 , Paula Garcia-Oliveira 1,2 , Maria Carpena 1 , Franklin Chamorro 1, Catarina Lourenço-Lopes 1, Miguel A. Prieto 1,* and Jesus Simal-Gandara 1,* 1 Nutrition and Bromatology Group, Analytical and Food Chemistry Department, Faculty of Food Science and Technology, Ourense Campus, University of Vigo, 32004 Ourense, Spain; [email protected] (M.F.-C.); [email protected] (P.O.); [email protected] (L.C.); [email protected] (J.E.); [email protected] (P.G.-O.); [email protected] (M.C.); [email protected] (F.C.); [email protected] (C.L.-L.) 2 Centro de Investigação de Montanha (CIMO), Campus de Santa Apolonia, Instituto Politécnico de Bragança, 5300-253 Bragança, Portugal 3 Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Veterinary, University of Santiago of Compostela, 27002 Lugo, Spain 4 Research Group of Food Engineering, Faculty of Engineering, National University of Mar del Plata, Mar del Plata RA7600, Argentina * Correspondence: [email protected] (M.A.P.); [email protected] (J.S.-G.) Abstract: Tannins are polyphenolic compounds historically utilized in textile and adhesive industries, Citation: Fraga-Corral, M.; Otero, P.; but also in traditional human and animal medicines or foodstuffs. Since 20th-century, advances in Cassani, L.; Echave, J.; analytical chemistry have allowed disclosure of the chemical nature of these molecules. The chemical Garcia-Oliveira, P.; Carpena, M.; profile of extracts obtained from previously selected species was investigated to try to establish a Chamorro, F.; Lourenço-Lopes, C.; bridge between traditional background and scientific data.
    [Show full text]
  • MOLECULAR INVESTIGATION of VALONEA TANNIN by H
    154 MOLECULAR INVESTIGATION OF VALONEA TANNIN by H. OZGUNAY1, O. SARI1 AND M. TOZAN2 1Ege University Faculty of Engineering Department of Leather Engineering 35100 BORNOVA-IZMIR - TURKEY 2TFL Deri Teknolojisi San. ve Tic. A. S. 34957 TUZLA-ISTANBUL - TURKEY ABSTRACT productos de la degradación y oxidación tal y cual son considerados como componentes principales del Valonea is one of many well-known vegetable tannins tanino de la Valonea. Más aun, castalegina/vescalegina, used in tanning and retanning processes for leather y aquellos residuos añadidos por unas cuantas making. Although it is used extensively in the leather estructuras/átomos, creando una molécula más industry, its main components and chemical structure grande y con más peso que las de castalegina/ are only gradually being identified. In order to vescalegina, y derivada de reestructuraciones internas investigate the chemical structure of valonea with en moléculas más grandes, constituyen los principales novel techniques, MALDI-TOF (Matrix-Assisted componentes de la valonea. Laser Desorption/Ionisation Time-of-Flight) and FTIR (Fourier Transform Infrared) Spectroscopy INTRODUCTION were used. The MALDI-TOF spectrum showed the presence of low molecular weight fraction of The leather industry is looking at options for metal-free hydrolysable tannins such as nonahydroxytriphnoic, tanning systems and especially tanning materials based on flavogallonic acid, ellagic and gallic acid, natural products such as vegetable tannins, which have gained pentagalloylglucose and all sorts of degradation and in importance. It is known that plants synthesize different oxidation products which are thought to be major polyphenolic substances, some of which may contribute to the components of valonea tannin. Moreover, formation of tannins.
    [Show full text]