CURRICULUM VITAE

Updated: September 11, 2019

Name: Sunil D. Kapila

Current Title and Department: Professor and Eugene E. West Endowed Chair Division of Orthodontics 707 Parnassus Avenue Department of Orofacial Sciences University of California San Francisco San Francisco, California, 94143

EDUCATION

Dates Institution Degree conferred, Attended and Location Title or Status Major Subject

1977-1981 University of Nairobi Bachelor of Dental Surgery Kenya Dental Surgery

1984-1987 University of Oklahoma Master of Science Orthodontics Health Sciences Center & Certificate of Oklahoma City Specialization

1987-1994 University of California Ph.D. Oral Biology San Francisco

LICENSES AND CERTIFICATIONS

1981 Bachelor of Dental Surgery, University of Nairobi, Kenya 1987 Certificate of Specialization in Orthodontics, University of Oklahoma 1987 Master of Science in Orthodontics, University of Oklahoma 1988 American Board of Orthodontics Phase II: Board Eligible 1989-Present California Board of Dental Examiners, Dental License #37681 1994 Doctor of Philosophy (Ph.D.) in Oral Biology, University of California San Francisco 1999-Present Diplomate, American Board of Orthodontics 2004-2016 Michigan State Board of Dentistry, Dental License 2004-2016 Michigan State Board of Dentistry, Specialty License

EMPLOYMENT

PRINCIPAL POSITIONS HELD

Dates Institution and Location Position

1981-1983 Kenyatta National Hospital Dental Officer Nairobi, Kenya

1983-1984 University of Nairobi Dental School Clinical Instructor & Tutor Nairobi, Kenya in Orthodontics

1993-1999 University of California San Francisco Assistant Professor Department of Growth and Development 2

1999-2004 University of California San Francisco Associate Professor Department of Growth and Development

2000-2001 University of California San Francisco Interim Chair Division of Orthodontics

2001-2004 University of California San Francisco Eugene E. West Endowed Chair Division of Orthodontics of Orthodontics

2004-2015 The University of Michigan Robert W. Browne Department of Orthodontics and Pediatric Dentistry Endowed Professor of Orthodontics in Dentistry and Chair

2004-2015 The University of Michigan Director of Graduate Orthodontics Department of Orthodontics and Pediatric Dentistry

2015-2016 The University of Michigan Thomas M. and Doris Graber Department of Orthodontics and Pediatric Dentistry Endowed Professor of Dentistry

2016-Present University of California San Francisco Professor and Eugene. E. West Department of Orofacial Sciences Endowed Chair of Orthodontics

2017-2019 University of California San Francisco CEO and Chief Dental Officer School of Dentistry UCSF Dental Center

2017-2019 University of California San Francisco Interim Graduate Orthodontics Department of Orofacial Sciences Program Director

ANCILLARY POSITIONS HELD CONCURRENTLY

1985-1986 University of Oklahoma Instructor Health Science Center Preclinical Orthodontics

1986-1987 University of Oklahoma Clinical Instructor Health Science Center in Orthodontics

1987-1988 University of California San Francisco Teaching Assistant Department of Growth and Development

1988-1993 University of California San Francisco Assistant Adjunct Professor Department of Growth and Development

1994-2004 University of California San Francisco Member Graduate Group in Oral Biology

1998-1999 University of California San Francisco Assistant Professor Department of Stomatology

1999-2004 University of California San Francisco Associate Professor Department of Stomatology

2004-2016 The University of Michigan Professor Oral Health Sciences Graduate Program

2012-2016 The University of Michigan Member Wireless Integrated MicroSystems (WIMS)

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2016-2017 The University of Michigan Adjunct Professor Department of Orthodontics and Pediatric Dentistry

2016-Present University of California San Francisco Member Graduate Group in Oral and Craniofacial Sciences

HONORS, AWARDS AND SCHOLARSHIPS

1984-1987 Fulbright Hayes Scholarship for graduate studies and research in orthodontics 1987-1992 Dean's Fellowship, School of Dentistry, University of California at San Francisco 1987-1992 Non-Resident Tuition Scholarship from the Dean of Graduate Division, University of California San Francisco 1989-1990 Regents Fellowship, University of California San Francisco 1993 Hatton Award Winner, American Association for Dental Research and Hatton Award Finalist, International Association for Dental Research 1994 Elected to Omicron Kappa Upsilon, National Dental Honor Society 1995 Milo Hellman Research Award, American Association of Orthodontists for research on "Matrix metalloproteinases and proteinase inhibitors in antigen-induced arthritis of the juvenile temporomandibular joint" 1999 B.F. Dewel Honorary Research Award, American Association of Orthodontists Foundation 2000 Second Annual Eugene E. West Lecture. UCSF Dental Alumni Association Annual Scientific Session, San Francisco. 2001-2004 Eugene E. West Endowed Chair of Orthodontics, UCSF 2004-2014 Robert W. Browne Endowed Professor of Orthodontics in Dentistry, University of Michigan, School of Dentistry 2007 Outstanding Alumnus Award, The University of Oklahoma College of Dentistry, Department of Orthodontics 2010-2012 Honorary Professorship, Nanjing University Stomatological Hospital, Nanjing, Peoples Republic of China 2012 16th Annual Robert E. Moyers Memorial Lecture, Ann Arbor, Michigan 2013 Salzmann Lecture, Annual Session of the American Association of Orthodontists, Philadelphia, Pennsylvania 2013 Elected as Fellow of the International College of Dentists 2014-2016 Thomas M. and Doris Graber Endowed Professor in Dentistry, University of Michigan, School of Dentistry 2015 University of California San Francisco 150th Anniversary Alumni Excellence Award Recipient 2015 1st Annual Ravindra Nanda Lecture, University of Connecticut School of Dental Medicine 2016-present Eugene E. West Endowed Chair of Orthodontics, UCSF 2018-2019 Burstone Fellow in Biomechanics. American Association of Orthodontists Foundation

CLINICAL ACTIVITIES

CLINICAL ACTIVITIES SUMMARY

I have been actively involved in patient care since I graduated from dental school first as a general dentist working in a Kenya Government Hospital (1981-1984) and then as an orthodontist (1984-present). My clinical activities include both providing care in faculty practices at UCSF and at University of Michigan and supervision of clinical care provided by graduate students. One of the key areas of emphasis in my faculty practice is treating complex cases requiring teamwork with dentists, dental specialists and physicians. I also place an emphasis in using current technologies such as virtual treatment planning in both my own practice and in the student clinics. I am a Diplomate of the American Board of Orthodontics.

CLINICAL SERVICE

1981-1984 General Dentistry and Orthodontics, Kenyatta National Hospital and University of Nairobi, Nairobi, Kenya

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1984-1987 Orthodontic Residency, University of Oklahoma College of Dentistry, Oklahoma City, Oklahoma 1987-2004 Orthodontic Intramural Practice, University of California San Francisco, School of Dentistry, San Francisco, California 2010-2016 Orthodontics Faculty Practice, The University of Michigan, School of Dentistry, Ann Arbor, Michigan 2019-present Orthodontic Faculty Practice, University of California San Francisco, School of Dentistry, San Francisco, California

PROFESSIONAL ACTIVITIES

MEMBERSHIPS

1981-1984 Kenya Dental Association 1985-present American Association of Orthodontists 1987-2000 American Dental Association 1988-present International Association for Dental Research 1988-present American Association for Dental Research 1988-present Craniofacial Biology Group of the IADR and AADR 1989-2004 California Dental Association 1993-2004 University of California Orthodontic Alumni Foundation 1993-2004 Pacific Coast Society of Orthodontists 1994-2004 American Society for Bone and Mineral Research 1994-2004 American Association for the Advancement of Science 1998-2004 San Francisco Dental Society 1999-2014 College of Diplomates of the American Board of Orthodontists 1999-present Mineralized Tissue Group of the IADR and AADR 2000-2004 American Dental Education Association 2003-2004 Associate Member of the Angle Society of Northern California 2004-2016 Great Lakes Association of Orthodontists 2004-2016 Michigan Association of Orthodontists 2010-2012 Affiliate Member, Edward H. Angle Society of Orthodontists, North Atlantic Component 2010-2012 Member of the American Dental Association, Michigan Dental Association and Washtenaw County Dental Association 2012-present Member, Edward H. Angle Society of Orthodontists, North Atlantic Component 2013-present Fellow of the International College of Dentists 2016-present Member, Pacific Coast Society of Orthodontists and California Association of Orthodontists 2016-present Member, University of California San Francisco Orthodontic Alumni Association

SERVICE TO PROFESSIONAL ORGANIZATIONS

1990 Judge: Scientific Session, American Association of Orthodontists 90th Annual Session, Washington D.C. 1992 Session Chair, Craniofacial Biology, Temporomandibular Disorders. General Session of the International and American Associations for Dental Research, Boston, Massachusetts. 1994 Invited participant: International Workshop on the Temporomandibular Disorders and Related Pain Disorders. Sponsored by National Institute of Dental Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, and the Office on Research on Women's Health. Hunt Valley, Maryland 1996 Session Chair, Craniofacial Biology, TMD and TMJ Condyle. General Session of the International and American Associations for Dental Research, San Francisco, California 1996 Organizer and Chair, Symposium on "Clinical Implications of Recent Scientific Advances in Orthodontics" at University of California San Francisco, San Francisco, California 1997 Session Chair, Craniofacial Biology, Fibroblasts, Chondroblasts and Osteoblasts. General Session of the International and American Associations for Dental Research, Orlando, Florida 1997-1999 Secretary-Treasurer, Rho Rho Chapter, Omicron Kappa Upsilon, National Dental Honor Society 4 5

1998 Invited participant: Beyond Hunt Valley: Research on Women’s Health for the 21st Century. Sponsored by Office of Research on Women’s Health, National Institutes of Health, Bethesda, Maryland. 1998 Moderator, American Association of Orthodontists Annual Session, Dallas, Texas for session on Biomechanics and Orthodontic Materials 1998 Session Chair, Craniofacial Biology, Craniofacial and Dental Development. General Session of the International Association for Dental Research, Nice, France. 1998-2000 Member, Joint Publications Committee, International and American Associations for Dental Research. 1998-1999 Co-organizer and Co-Chair, Craniofacial Biology Symposium on “Skeletal and Connective Tissue Remodeling in Orthodontic and Dentofacial Orthopedic Treatment” for the 1999 General Session of the International and American Associations for Dental Research, Vancouver, British Columbia. 1999-2002 President, Conferences on Orthodontic Advances in Science and Technology (COAST: A science transfer symposia series) 2000 Session Chair, Craniofacial Biology, Osteoblasts and Temporomandibular Disorders, General Session of the International and American Associations for Dental Research, Washington D.C. 2000-2002 Founding Member and President, Conferences on Orthodontic Advances in Science and Technology (COAST) Foundation 2000-2002 Organizer, COAST Foundation’s Inaugural Symposium. Craniofacial Imaging in the 21st Century. Asilomar Conference Center, September 6 to 9, 2002. 2000 Judge, Sarnat Award Competition, Craniofacial Biology Group, International Association for Dental Research 2001-2004 Member, Council on Scientific Affairs, American Association of Orthodontists 2002-2005 Director, Craniofacial Biology Group, International Association for Dental Research. 2002-2005 Member, Hatton Awards Committee, American Association for Dental Research. 2003-2005 Scientific Advisory Board Member, Conferences on Orthodontic Advances in Science and Technology 2nd Symposium on “Craniofacial Skeletal Bioengineering.” 2003-2004 Program Committee Member, CARS 2004 Computed Assisted Radiology and Surgery Conference. 10th Computed Maxillofacial Imaging Congress. Chicago, IL. 2004-2006 Organizing Committee: Third Biennial Symposium of COAST Foundation. “Craniofacial Skeletal Anomalies: From Genes to Therapies.” 2005 Abstract Reviewer, Craniofacial Biology Group, American Association for Dental Research. 2005 Moderator, American Association of Orthodontists Annual Session, Toronto, Canada for session on Biomechanics and Orthodontic Materials 2005-present Organizing Committee, Moyers Symposium and International Conference on Craniofacial Research 2006-2007 Vice President, Craniofacial Biology Group, International Association for Dental Research. 2006-2008 Organizing Committee and Scientific Advisory Board: Fourth Biennial Symposium of COAST Foundation. “Biomedicine in Orthodontics; From Tooth Movement to Growth Modification.” 2007 Chair, Sarnat Competition, Craniofacial Biology Group, International Association for Dental Research. 2007 Session Chair, Craniofacial Biology, Temporomandibular Disorders, General Session of the International and American Associations for Dental Research, New Orleans, LA. 2007 Member, American Association of Orthodontists Foundation, Strategic Long Range Planning Committee. 2007-2008 President Elect, Craniofacial Biology Group, International Association for Dental Research. 2007-2008 Group Program Chair, Craniofacial Biology Group, International Association for Dental Research. 2008 Abstract Reviewer, Craniofacial Biology Group, American Association for Dental Research. 2008 Session co-chair, on Temporomandibular Joint Development and Engineering. Craniofacial Biology Group, International Association for Dental Research. 2008-2009 President, Craniofacial Biology Group, International Association for Dental Research. 2009-2010 Immediate Past President, Craniofacial Biology Group, International Association for Dental Research. 2010-2016 Member, American Association of Orthodontists Foundation’s Planning and Awards Review Committee

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2010 Moderator, American Association of Orthodontists Annual Session, Washington DC for session on Temporomandibular Disorders 2010 External Reviewer, Graduate Program in Orthodontics at the University of Illinois, Chicago. 2010-2016 Program Organizer and Director, Advanced Orthodontics Mini Residency for Portugese- speaking Audience 2010-2015 Co-director of University of Michigan School of Dentistry’s Kenya Summer Research Program. 2010-2012 Organizing Committee and Scientific Advisory Board: Fifth Biennial Symposium of Consortium for Orthodontic Advances in Science and Technology (COAST). “Neuromuscular- Skeletal Craniofacial Biology: Translating Bench Research to Clinical Practice.” 2011-2016 Chair, American Association of Orthodontists Foundation’s Planning and Awards Review Committee (PARC) 2011-2016 Ad Hoc Member, American Association of Orthodontists Foundation Board of Directors 2011 Moderator, American Association of Orthodontists Annual Session, Chicago, Illinois for session on Temporomandibular Disorders 2011 Program Organizer and Director. Advanced Orthodontics Mini Residency for Spanish-speaking Audience 2011-2012 Director & Organizer of the 39th Annual Moyers Symposium and the International Conference on Craniofacial Research (Presymposium) “Cone Beam Computed Tomography in Orthodontics: Indications, Insights and Innovations” 2013-2018 Organizing Committee and Scientific Advisory Board: 6th, 7th & 8th Biennial Symposium of Consortium for Orthodontic Advances in Science and Technology (COAST). “Personalized and Precision Orthodontic Therapy” 2013-2014 Director & Organizer of 41st Annual Moyers Symposia and the International Conference on Craniofacial Research (Presymposium) “Expedited Orthodontics: Improving the Efficiency of Orthodontic Treatment Through Novel Technologies” 2013 External Examiner, Department of Orthodontics, University of Western Australia, Perth, Australia. 2014-2015 Director & Organizer of 42nd Annual Moyers Symposia and the International Conference on Craniofacial Research (Presymposium) “Interdisciplinary Therapy: Optimizing Treatment in Complex Cases” 2015-2018 Councilor, Craniofacial Biology Group of the International Association for Dental Research. 2015-2016 Director & Organizer of 43rd Annual Moyers Symposia and the International Conference on Craniofacial Research (Presymposium) “Anecdote, Expertise and Evidence: Applying New Knowledge to Everyday Orthodontics” 2016 Cincinnati Children’s Hospital Dental Program Reviewer 2018 Judge, Sarnat Competition, Craniofacial Biology Group of the International Association for Dental Research.

SERVICE TO PROFESSIONAL PUBLICATIONS

1990-present Ad Hoc Reviewer, American Journal of Orthodontics and Dentofacial Orthopedics 1990-present Ad Hoc Reviewer, Angle Orthodontist 1992 Ad Hoc Reviewer, Archives of Oral Biology 1994-1997 Ad Hoc Reviewer, Journal of Orofacial Pain 1994-present Ad Hoc Reviewer, Journal of Dental Research 1996 Ad Hoc Reviewer, FASEB Journal 1997-2007 Member, Editorial Board, Angle Orthodontist 1998 Ad Hoc Reviewer, Journal of Oral Pathology and Medicine 1997-2001 Discussant, Journal of Oral and Maxillofacial Surgery 1999-2001 Ad Hoc Reviewer, Clinical Orthodontics and Research 2000-2005 Ad Hoc Reviewer, European Journal of Oral Sciences 2002-2003 Proceedings Editor, Proceedings on “Craniofacial Imaging in the 21st Century” Orthodontic and Craniofacial Research Journal. 2004-2010 Ad Hoc Reviewer: Arthritis and Rheumatism 2004-2010 Ad Hoc Reviewer, Arthritis Research and Therapy 2004-2007 Ad Hoc Reviewer, Journal of Oral and Maxillofacial Surgery 2004-2010 Reviewer, Journal of Oral Pathology, Oral Surgery, Oral Medicine and Endodontics

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2004-2005 Proceedings Editor, Proceedings on “Craniofacial Skeletal Bioengineering” Orthodontic and Craniofacial Research Journal 2005-2009 Editorial Board, Journal of Dental Research 2006-2012 Ad Hoc Reviewer, Journal of Bone and Mineral Research 2007-2012 Ad Hoc Reviewer, Bone 2007-2014 Ad Hoc Reviewer, Tissue Engineering 2008-2011 Editorial Board, International Journal of Oral Science 2008-2014 Ad Hoc Reviewer, Calcified Tissue International 2008-present Ad Hoc Reviewer, Stem Cell and Development 2008-2009 Proceedings Editor, Proceedings on “Biomedicine in Orthodontics: From Tooth Movement to Growth Modification” Orthodontic and Craniofacial Research Journal 2010-present Ad Hoc Reviewer, Orthodontic and Craniofacial Research 2013-present Associate Editor, Progress in Orthodontics 2013-2017 Editor-in-Chief, Moyers Symposium Monographs #51, 52 and 53 2015-2017 Proceedings Editor, Proceedings on “Personalized and Precision Orthodontic Therapy” Orthodontic and Craniofacial Research 2016-present Editorial Board, Journal of Orthodontics 2018-present Associate Editor, Orthodontics and Craniofacial Research

NATIONAL AND INSTITUTIONAL GRANT REVIEWS

1999-2002 Grant Reviewer, Academic Senate, University of California San Francisco 2001 Grant Reviewer, NIH / NIDCR Special Emphasis Panel. International Collaborative Oral Health Research Centers Planning Grants 2002 Ad Hoc Grant Reviewer, NIH/NIDCR R13 Conference Grant 2003 Grant Reviewer, Special Emphasis Panel, Pathobiology of TMJ Disorders, NIH/NIDCR 2006 Ad Hoc Grant Reviewer, NIH/NIDCR R13 Conference Grant 2006 Ad Hoc Grant Reviewer, NIH/NIDCR Training K Awards and R03 Grant Mechanisms 2008-2016 Grant Reviewer, American Association of Orthodontists Foundation 2009 Ad Hoc Grant Reviewer, NIH/NIAMS, RFA AR-10-010; Ancillary Studies on Large Ongoing Clinical Projects (RO1) 2009-2012 Ad Hoc Grant Reviewer, Qatar National Research Foundation, Doha, Qatar 2009-2010 Chair, Grant Review Panel, NIH/NIDCR U13 Grant 2009-2011 Member, American Association of Orthodontists Foundation, Planning and Awards Review Committee (PARC) 2011-2017 Chair, American Association of Orthodontists Foundation, Planning and Awards Review Committee (PARC) 2014 Ad Hoc Grant Reviewer, NIH/NIDCR, PAR-11-289; Institutional Career Development Award for Enhancing Research Capacity in TMJDs and Orofacial Pain (K12). 2016 Grant Reviewer, European Orthodontic Society. 2017-present Grant Reviewer, Center for Dental, Oral & Craniofacial Tissue & Organ Regeneration (C- DOCTOR)

INVITED PRESENTATIONS - INTERNATIONAL

1983 International Workshop on Fluoride Research Strategies, Nairobi, Kenya. “Fluorides and Fluorosis in Kenya - an overview”. (also see Chapters)

1994 Conference on Interactive Jaw Mechanics on Force Distribution and Masticatory Tissue Response, Squaw Valley, California. “Mechanisms of Tissue Loss in TMJ Arthritis: The Role of Matrix Degrading Enzymes” (also see Chapters)

1994 Conference on Interactive Jaw Mechanics on Force Distribution and Masticatory Tissue Response, Squaw Valley, California. “Mechanical Considerations in Degenerative Joint Disease: Tissue Turnover in Response to Joint Loading” (also see Chapters)

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1995 Moyers Symposium, University of Michigan, Ann Arbor, Michigan. “Matrix metalloproteinases and proteinase inhibitors in antigen-induced arthritis of the juvenile temporomandibular joint” (also see Chapters)

1995 Annual Session of the International Orthodontic Congress and the American Association of Orthodontists, San Francisco, California. Milo Hellman Award Recipient Speaker on “Matrix Metalloproteinases and proteinase inhibitors in antigen-induced arthritis of the juvenile rabbit temporomandibular joint”

1996 Danish Orthodontic Society, Aarhus, Denmark. “Biologic basis for the diagnosis and treatment of TMJ diseases”

1996 Department of Orthodontics, Royal Dental College, Aarhus, Denmark. “Clinical implications of bracket- wire friction in orthodontic mechanotherapy”

1996 Department of Orthodontics, Royal Dental College, Aarhus, Denmark. “Material properties and optimal clinical applications of orthodontic wires”

1996 Royal Dental College, Aarhus, Denmark. “Development and research applications of animal models of TMJ disease”

1997 Keynote Speaker at the World Congress on Orthodontics and 31st Indian Orthodontic Conference, New Delhi, India. “Optimal clinical applications of contemporary orthodontic wires”

1998 American Association of Orthodontists Annual Session, Dallas, Texas. “TMJ diseases: Diagnostic methods and therapies in the new millennium”

1999 International and American Associations of Dental Research Craniofacial Biology Symposium on Skeletal and Connective Tissue Remodeling in Orthodontic and Orthopedic Treatment. Vancouver, British Columbia “Alterations in cell-matrix interactions modulate matrix degradation in connective tissues”.

1999 Biologic Mechanisms of Tooth Movement and Craniofacial Adaptation Conference, Harvard Society for the Advancement of Orthodontics in Seoul, Korea. “The role of matrix metalloproteinases in orthodontic tooth movement”

2003 American Association of Orthodontists Annual Session, Honolulu, Hawaii. “Efficient treatment through selective mechanics”

2003 Sun Valley Hard Tissue Workshop, Sun Valley, Idaho. “Does the relaxin, estrogen and matrix metalloproteinase axis contribute to the degradation of TMJ fibrocartilage”

2003 Kenya Dental Association, Nairobi, Kenya. “The role of orthodontics in multidisciplinary treatments”

2004 American Association of Orthodontists, Orlando, FL. “Understanding TMJ Disorders: Future Innovations in Diagnosis and Treatments”

2004 Graduate Orthodontic Residents Program (GORP), Ann Arbor, MI. “Understanding TMJ Disorders: Future Innovations in Diagnosis and Treatments”

2005 American Association of Orthodontists, San Francisco, CA. “Materials and Mechanics Interface in Attaining Efficient Treatment Outcomes”

2007 Shanghai Jiatong University 9th Hospital, Shanghai, China. “Understanding TMJ Disorders: Future Innovations in Diagnosis and Treatments”

2007 Peking University School of Stomatology, Beijing, China. “Understanding TMJ Disorders: Future Innovations in Diagnosis and Treatments”

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2007 Tianjin Medical University School of Stomatology, Tianjin, China. “Understanding TMJ Disorders: Future Innovations in Diagnosis and Treatments”

2007 Xi’an Jia Tong University School of Dentistry, Xi’an, China. “Understanding TMJ Disorders: Future Innovations in Diagnosis and Treatments”

2007 International Association for Dental Research. “Targeted Degradation of TMJ Fibrocartilage via Hormone- MMP Axis.” Symposium. Title- “Gender Effects on Temporomandibular Disorders.”

2008 Moyers Symposium. Ann Arbor, Michigan. “Current and Future Innovations in TMD Diagnostics and Therapeutics.”

2008 American Association of Orthodontists, Denver, CO. “Optimizing Treatment Mechanics in Complex and Compromised Cases.”

2008 Relaxin 2008. 5th International Conference on Relaxin and Related Peptides. Kaanaapali, Hawaii. “Relaxin’s Induction of Specific MMPs Contributes to Degradation of Cartilage in Target Synovial Joints: Receptor Profiles Correlate with Matrix Remodeling Responses.

2008 4th Biennial Meeting of the COAST Foundation on Biomedicine in Orthodontics: From Tooth Movement to Facial Growth. Pacific Grove, CA. “Hormonal Pathobiology of Temporomandibular Joint (TMJ) Degeneration”

2008 1st Collaborative Research Symposium- University of Michigan, Federal University of Sao Paulo and Federal University of Rio Grande Del Sul, Porto Allegre, Brazil. “Matrix Metalloproteinases in Periodontal Osteolysis and Regeneration.”

2009 Shanghai Jia Tong University 9th Hospital, Shanghai, China. “Optimized Biomechanics in Complex and Compromised Cases.”

2009 Nanjing University Stomatological Hospital, Nanjing, China. “Optimized Biomechanics in Complex and Compromised Cases.”

2009 University of Poznan, 50th Anniversary Celebrations Conference, Poznan, Poland. “Optimized Biomechanics in Complex and Compromised Cases.”

2009 University of Poznan, 50th Anniversary Celebrations Conference, Poznan, Poland. “Complex and Interdisciplinary Case Conference.”

2009 Indian Orthodontic Society Meeting, New Delhi, India. “Optimized Biomechanics in Complex and Compromised Cases.”

2010 American Association of Orthodontists Annual Session, Washington DC. “Pathways to Success in Academic Orthodontics.”

2010 American Association of Orthodontists Annual Session, Washington DC. “TMJ Disorders: Innovations in Diagnostics and Therapeutics.”

2010 Advanced Orthodontics Mini-residency for Portuguese-speaking audience, Ann Arbor, MI. “Selective Biomechanics and Materials for Effective and Efficient Treatments.”

2010 DenTech China 2010 Conference, Shanghai, China. “Orthodontic and Dental Considerations for Optimizing Treatment Results in Interdisciplinary Cases.”

2010 DenTech China 2010 Conference, Shanghai, China. “The Use of CBCT in Diagnosis and Treatment of Transposed Teeth: Lessons Learnt from a Case.”

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2010 Jiangsu Stomatological Association Inaugural Meeting, Nanjing China. “TMJ Disorders: Innovations in Diagnostics and Therapeutics.”

2010 Nanjing University Stomatological Hospital, Nanjing, China. “Treatment Planning and Sequencing of Complex Interdisciplinary Cases”

2011 American Association of Orthodontists Annual Session, Chicago, IL. “Planning and Implementing Optimal Biomechanics in 3D: Applications to Impacted and Transposed Teeth.”

2011 Tokyo Medical and Dental University, Tokyo, Japan. “Biomedicine in Orthodontics: From Tooth Movement to Tissue Engineering.”

2011 Tokyo Medical and Dental University, Tokyo, Japan. “Planning and Implementing Optimal Biomechanics in 3D: Applications to Impacted and Transposed Teeth.”

2011 Japanese TMJ Society Meeting, Hiroshima, Japan. “TMJ Disorders: Innovations in Diagnostics and Therapeutics.”

2011-13 Advanced Orthodontics Mini-residency for Spanish-speaking audience, Ann Arbor, MI. “Selective Biomechanics and Materials for Effective and Efficient Treatments.”

2012 Moyers Symposium, Keynote Speaker, Ann Arbor, Michigan. “Current Status of CBCT Imaging in Orthodontics.”

2012 American Association for Dental Research Symposium on TMJ Stem Cell Biology and Engineering Towards Clinical Translation, Tampa, Florida. “Hormonal Pathobiology of TMJ Degeneration: Implications to Diagnostics and Therapeutics.”

2012 Edward H. Angle Society of Orthodontists, North Atlantic Component. Barcelona, Spain. “Female Hormone Receptors are Differentially Expressed in Mouse TMJ, Knee and Pubic Fibrocartilages.”

2012 The Lebanese Orthodontic Society and Association Francophone Orthodontie Pluridisciplinaire Scientific Meeting. Beirut, Lebanon. “3D Image-aided Treatment of Impacted and Transposed Teeth.”

2012 The Lebanese Orthodontic Society and Association Francophone Orthodontie Pluridisciplinaire Scientific Meeting. Beirut, Lebanon. “Optimizing Treatment Mechanics in Complex and Compromised Cases.”

2012 American Association of Orthodontists Annual Session. Honolulu, Hawaii. “3D Image-aided Treatment of Impacted and Transposed Teeth.”

2012 Dominican Republic Orthodontic Society, San Domingo, Dominican Republic. “Selective Biomechanics and Biomaterials for Effective and Efficient Treatments.”

2012 Relaxin 2012. 6th International Conference on Relaxin and Related Peptides, Florence, Italy. “Mechanisms for Relaxin’s Modulation of MMPs and Matrix Loss in Fibrocartilages.”

2012 Italian Orthodontic Society Meeting, Florence, Italy. “3D Image-aided Treatment of Impacted and Transposed Teeth.”

2013 Panamaniam Orthodontic Society, Panama City, Panama. “Selective Biomechanics and Biomaterials for Effective and Efficient Treatments.”

2013 American Association of Orthodontists Annual Session, Salzmann Lecture, Philadelphia, Pennsylvania. “Biomedicine- and Technology-driven Paradigm Shifts in Orthodontics.”

2013 Paranese Orthodontic Society, Curitiba, Brazil. “Selective Biomechanics and Biomaterials for Effective and Efficient Treatments.”

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2013 Western Australia Orthodontic Society, Perth, Australia. “Optimized Biomechanics in Complex and Compromised Cases” and “3D Image-aided Treatment of Impacted and Transposed Teeth.”

2013 University of Western Australia, Department of Orthopedic Surgery, Perth, Australia. “Mechanisms for Relaxin’s Modulation of MMPs and Matrix Loss in Fibrocartilages.”

2014 University of Naples and Naples Orthodontic Society, Naples, Italy. “3D Image-aided Treatment of Impacted and Transposed Teeth.”

2014 Canadian Orthodontic Association. Melbourne, Canada. “3D Image-aided Treatment of Impacted and Transposed Teeth.”

2014 Consortium on Orthodontic Advances in Science and Technology (COAST) 6th Biennial Conference, Keynote Address, Chicago, IL. “The Promise and Challenge of Precision Orthodontics”

2014 Belgian Orthodontic Society. “Optimized Treatment Mechanics in Complex and Compromised Cases,” “3D Image-aided Treatment of Impacted and Transposed Teeth” and “Orthodontic Treatment in 90 Days: The Future Promise of Biomedicine and Technology.” Brussels, Belgium.

2015 American Association of Orthodontists Annual Session, San Francisco, CA. “New Horizons in Expedited Orthodontics: The Future Promise of Technology and Biomedicine”

2015 8th International Orthodontics Congress, World Federation of Orthodontists. “3D Image-aided Treatment of Impacted and Transposed Teeth.” London, England.

2015 American Association of Oral and Maxillofacial Surgeons 2015 Annual Meeting. “Virtual Tooth Movement and Occlusal Planning for Orthognathic Surgery.” Washington DC.

2015 Colombian Society of Orthodontists. “Orthodontics in 5D: Enhancing Treatment Efficiency and Outcomes.” Cali, Colombia.

2016 Malaysian Orthodontic Society. ““Orthodontics in 5D: Enhancing Treatment Efficiency and Outcomes.” Langkawi, Malaysia.

2016 Chilean Orthodontic Society. “Orthodontics in 5D: Enhancing Treatment Efficiency and Outcomes.” Santiago, Chile.

2017 New Zealand Association of Orthodontists. “Orthodontics in 5D: Enhancing Treatment Efficiency and Outcomes.” Queenstown, New Zealand.

2017 International Association for Dental Research, National Student Research Group. “Beyond Dental School: Continuing your Research to Become a Leader in your Specialty” San Francisco, CA. (symposium panelist)

2017 American Association of Orthodontists Annual Session. “Integrating Technology and Biomedicine Towards Precision Orthodontics.” San Diego, CA.

2017 International Orthodontic Forum- Orthodontic and Periodontal Interdisciplinary Treatment. “The Myths and Realities of Expedited Orthodontics” and “Dentoalveolar Boundary Conditions in Planning Orthodontic Treatment.” Nanjing University, Nanjing, China.

2017 Chilean Orthodontic Society Mini Residency. Orthodontics in 5D: Enhancing Treatment Efficiency and Outcomes.” San Francisco, CA.

2018 American Association of Orthodontists Annual Session. “Emerging Applications of CBCT in Orthodontic Diagnosis and Treatment Planning.” Washington DC.

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2019 UCSF / University of Nairobi Kenya Oral Health Program. “Optimal Management of Complex Interdisciplinary Cases.” Nairobi, Kenya

INVITED PRESENTATIONS – NATIONAL

1982 Swedish Dental Association, Nairobi, Kenya. “Prevalence of malocclusions in African and Asian children in Nairobi schools”

1984 Hepatitis B Virus in East Africa Seminar, Nairobi, Kenya. “Hepatitis B viral serology in dental and paradental staff in Kenya”

1992 Pacific Coast Society of Orthodontists, Honolulu, Hawaii. “Clinical considerations of friction in orthodontic treatment”

1998 Annual Session of the American Association for Dental Schools, Washington D.C. “Utilizing the strengths of academia and industry to enhance orthodontic education”

1999 Keynote Speaker, Workshop on Inflammation, Pain and Temporomandibular Disorders, Dallas. Texas. “Understanding the mechanisms of TMJ diseases: Implications for diagnosis and treatment”

2000 North East Society of Orthodontists, New York, NY. “Efficient treatment through SMART mechanics”

2006 University of Oklahoma Orthodontic Alumni Meeting, Las Vegas, Nevada. “Materials and Mechanics Interface in Attaining Efficient Treatment Outcomes.”

2007 Moyers Presymposium, Ann Arbor, Michigan. “Implants and Beyond in the Age of Biomedicine.”

2007 The University of Connecticut School of Dental Medicine Dean’s Seminar, Farmington, Connecticut. “Hormonal Pathobiology of TMJ Degeneration”

2007 The University of Washington 2007 Distinguished Professor in Dentistry Symposium. “Current Concepts in TMJ Disorders: Imaging and Biomedicine for Rational Diagnosis and Treatments.” Seattle, Washington.

2008 Orthodontic Education and Research Foundation. “Biomedicine in Orthodontics: Applications to TMJ Disorders and Tooth Movement.” St. Louis, Missouri.

2009 Pacific Coast Society of Orthodontists. “TMJ Disorders: Current and Future Innovations in Diagnostics and Therapeutics.” Phoenix, Arizona.

2011 International Conference on Craniofacial Research. “Biomedical Approaches to Orthodontic Tooth Movement and Retention.” Ann Arbor, Michigan.

2012 13th Annual Robert E. Moyers Memorial Speaker. 39th Annual Moyers Symposium. “Current Status of CBCT Imaging in Orthodontics. Ann Arbor, Michigan.

2012 American Association for Dental Research. “Hormonal Pathobiology of TMJ Degenerations: Implications to Diagnostics and Therapeutics.” Symposium Title- TMJ: Stem Cell Biology and Engineering Towards Clinical Translation.” Tampa, Florida.

2012 Consortium for Orthodontic Advances in Science and Technology. “Mechanisms for Hormonal Modulation of MMPs and Matrix Loss in Fibrocartilages.” Chapel Hill, North Carolina.

2012 Pacific Coast Society of Orthodontists. “3D Image-aided Treatment of Impacted and Transposed Teeth.” Monterey, California.

2013 40th Annual Moyers Symposium. “Biomedicine in Orthodontics: Regulating Tooth Movement and Enhancing Retention.” Ann Arbor, Michigan. 12 13

2013 American Association of Orthodontists and American Academy of Periodontics Mid-winter Meeting. “3D Image-aided Treatment of Impacted and Transposed Teeth.” Palm Springs, California.

2013 3rd Annual Burstone Symposium. “3D Image-aided Treatment of Impacted and Transposed Teeth.” Indianapolis, Indiana.

2014 Consortium for Orthodontic Advances in Science and Technology. “Precision Orthodontics Driven by Technology and Biomedicine.” Eaglewood, IL.

2015 UConn Orthodontic Symposium. “3D Image-aided Treatment of Impacted and Transposed Teeth.” Farmington, Connecticut.

2016 Consortium for Orthodontic Advances in Science and Technology. “From Laboratory to Chairside: What Should We Expect in the Next 20 Years.” West Palm Beach, Florida.

2018 College of the Diplomates of the American Board of Orthodontics. “Optimized Treatment of Impacted and Transposed Teeth Using 3D Imaging & Mechanics”. Orlando, Florida

2018 TMJ Bioengineering Conference. “Hormone-Receptor-MMP Axis in the Targeted Degradation of TMJ Fibrocartilage and Subchondral Bone.” Los Angeles, CA.

INVITED PRESENTATIONS – REGIONAL AND OTHER INVITED PRESENTATIONS

1987 Oklahoma Orthodontic Society, Western Hills, Oklahoma. “Post-orthodontic treatment of localized decalcification with hydrochloric acid-pumice technique”

1991 Medico-Dental Guild of California, San Francisco, California. “Mandibulofacial adaptations following induced lateral deviation of the mandible”

1991 Temporomandibular Dysfunction Group, San Francisco, California. “Biochemical mediators of temporomandibular joint degeneration in experimental arthritis”

1992 University of California Orthodontic Alumni Foundation, Monterey, California. “Is bracket - wire friction of importance in clinical orthodontics?”

1992 Department of Growth and Development, UCSF, San Francisco, California. “Matrix metalloproteinases and inhibitors in antigen-induced arthritis of the temporomandibular joint”

1992 Temporomandibular Joint Dysfunction Group, San Francisco, California. “Embryogenesis, histology and mechanisms of temporomandibular joint degeneration”

1993 University of Pacific Dental School, San Francisco, California. “Clinical implications of bracket-wire friction in orthodontic treatment”

1993 John E. Gurley Dental Alumni Day, UCSF, San Francisco, California. “Recent advances in Orthodontics: Implications to dentistry”

1994 University of California Orthodontic Alumni Foundation, San Francisco, California. “Future directions in the diagnosis and treatment of TMDs”

1994 San Francisco Bone and Mineral Club, San Francisco, California. “Matrix metalloproteinases and inhibitors in experimental arthritis”

1994 Symposia in Honor of Dean John Greene, UCSF, San Francisco, California. “The biology of temporomandibular joint degeneration”

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1994 Oral and Maxillofacial Surgery / Orthodontic, Orthognathic Surgery Grand Rounds, UCSF, San Francisco, California. “Biological basis for TMJ degeneration in arthritis”

1994 Temporomandibular Joint Dysfunction Group, San Francisco, California. “Pathophysiology of temporomandibular joint degeneration”

1995 University of Florida, College of Dentistry, Gainesville, Florida. “The biology of TMJ degeneration: Role of matrix metalloproteinases and their inhibitors”

1995 Angle Society of Northern California, San Mateo, California. “Future directions in the diagnosis and treatment of temporomandibular joint diseases”

1995 Prosthodontic Residents Conference, San Francisco, California. “Future directions in the diagnosis and treatment of temporomandibular joint diseases”

1995 Temporomandibular Joint Dysfunction Group, San Francisco, California. “The biologic basis for diagnosis and treatment of TMJ diseases”

1996 Seminar Series on Osteoporosis and Bone Biology, UCSF, San Francisco, California. “Load-induced changes in matrix macromolecules in cultured chondrocytes”

1996-00 Oral and Maxillofacial Surgery / Orthodontic Grand Rounds, UCSF, San Francisco, California. “Future directions in the diagnosis and treatment of TMJ disease”

1996 University of Pacific School of Dentistry. “Biologic basis of the diagnosis and treatment of TMJ diseases”

1997 Ohio State University, College of Dentistry, Columbus, Ohio. “Future directions in the diagnosis and treatment of TMJ diseases”

1997 University of Connecticut Health Sciences Center, Hartford, Connecticut. “The evolution of treatments for TMJ diseases”

1997 University of Florida, College of Dentistry, Gainesville, Florida. “Biomedical approaches to rational therapies for TMJ diseases”

1998 University of Michigan, School of Dentistry, Ann Arbor, Michigan. “Mechanisms of action of female reproductive hormones in TMJ diseases”

1998 University of California San Francisco, presentation to Chancellor Designate Dr. Bishop and faculty of the School of Dentistry. “The role of female reproductive hormones in the etiopathogenesis of TMJ diseases”

1999 UCSF Dental Alumni Association Annual Scientific Session, San Francisco. “Mechanisms of action of female reproductive hormones in TMJ disease”

2000 Oregon Health Sciences University, School of Dentistry, Portland, Oregon. “Recent findings for mechanisms of TMJ diseases: Potential indicators for novel therapies”

2000 UCSF Dental School. “Understanding Temporomandibular Joint Diseases: A Model for Integrating Translational Research into Dental Education”

2000 Second Annual Eugene E. West Lecture. UCSF Dental Alumni Association Annual Scientific Session, San Francisco. “The role of orthodontics in multidisciplinary treatment”

2000 UCSF/UCB Graduate Group in Biomedical Engineering. UCSF, San Francisco, California. “Bioengineering a mature fibrocartilaginous TMJ disc”

2000 Southern Alameda Dental Society. Pleasanton, California. “Future directions in the diagnosis and treatment of TMJ diseases” 14 15

2001 Pacific Coast Society of Orthodontics, San Francisco, California. “Optimizing treatment results in complex cases”

2002 Pacific Coast Society of Orthodontics, Los Angeles, California. “Optimizing treatment results in complex cases”

2003 University of Michigan School of Dentistry. “Understanding Temporomandibular Joint Diseases: A Model for Integrating Translational Research into Dental Education”

2005 Ann Arbor Study Group. “Treatment Mechanics and Coordination in Complex Cases”

2006 University of Illinois, Chicago. “Materials and Mechanics Interface in Attaining Efficient Treatment Outcomes” and “Understanding TMJ Disorders: Future Innovations in Diagnosis and Treatments”

2006 George Eastman Study Group, Warwick Hills, Michigan. “Contemporary Techniques in Interdisciplinary and Complex Cases.”

2007 The University of Oklahoma College of Dentistry, Oklahoma City, Oklahoma. “Optimized Treatment Mechanics in Complex and Compromised Cases”

2007 The University of Connecticut School of Dental Medicine, Farmington, Connecticut. “Contemporary Techniques in Complex and Interdisciplinary Treatments”

2008 Ohio State University, College of Dentistry, Department of Orthodontics. “Optimizing Treatment Mechanics in Complex and Compromised Cases.”

2010 University of Maryland School of Dentistry, Department of Orthodontics. “Optimizing Treatment Mechanics in Complex and Compromised Cases.”

2014 University of Michigan Orthodontic Alumni Association. “Recent Orthodontic Discoveries and Successes at Michigan.” Ann Arbor, MI.

2014 University of California San Francisco. “Hormone-Receptor-MMP Axis in Degenerative TMJ Diseases.” San Francisco, CA.

2014 Oregon Health Sciences University School of Dentistry Dean’s Seminar. “Temporomandibular Joint Disorders: Innovations in Diagnostics and Therapeutics.” Portland, OR.

2015 Peninsula Orthodontic Research Group. “Orthodontics in 4D: Enhancing Treatment Efficiency and Outcomes.” San Mateo, CA.

2015 University of California San Francisco, School of Dentistry. “Modulation of Temporomandibular Joint Degeneration by Sex Hormones.” San Francisco, CA.

2016 Eugene E. West Lecture, University of California Orthodontic Alumni Association. “Orthodontics in 5D: Enhancing Treatment Efficiency and Outcomes.” Napa Valley, California

2017 Edward H. Angle Society of Northern California. “The Myths and Realities of Expedited Orthodontics Treatment.” Oakland, CA.

2017 Pacific Coast Society of Orthodontists Annual Meeting. “Orthodontics in 5D: Optimizing Treatment Efficiency and Outcomes.” Reno, NV.

2018 UCSF Fresno Continuing Dental Education Program. “Current Concepts in Expedited and Precision Orthodontics.” Fresno, CA.

POSTGRADUATE AND CONTINUING EDUCATION COURSES ATTENDED 15 16

All continuing education requirements for California State Dental Board license have been met.

UNIVERSITY AND PUBLIC SERVICE

SERVICE ACTIVITIES SUMMARY My initial University service included student leadership roles at the University of Oklahoma as President of the Graduate Student Association and its attendant responsibilities within the institution. During my previous employment at UCSF, I served in departmental, school-wide, campus-wide and systemwide committees that provided me a broad exposure to institutional organization and operations. Similarly, I have served as a member or chair of many committees at the University of Michigan and now again at UCSF. The committees I have served on have a broad range of interests and responsibilities including student and continuing education, research and clinical activities, facility remodeling, financial and efficiency enhancements, organizational structure and public service.

UC SYSTEM AND MULTI-CAMPUS SERVICE

1994-1996 UCSF Delegate to Assembly of the University of California Systemwide Academic Senate 1994-1996 Member, Coordinating Committee of the University of California San Francisco Academic Senate

CAMPUSWIDE

1984-1985 President, International Students Organization, University of Oklahoma Health Sciences Center 1986-1987 President, Graduate Student Association, University of Oklahoma Health Sciences Center 1986-1987 Member, Graduate Council, University of Oklahoma Health Sciences Center 1986-1987 Member, Student Council, University of Oklahoma Health Sciences Center 1986-1987 Member, Academic Misconduct Board of the Graduate College, University of Oklahoma Health Sciences Center 1998-2001 Member, Academic Senate Committee on Research, UCSF 1998 Chair, Ad Hoc Committee for Nominating Burroughs-Wellcome Fellows, UCSF 2018-present Member, Quality Improvement Executive Committee 2018-2019 Clinical Care Subcommittee of UCSF Technology Governance Committee

SCHOOL OF DENTISTRY

1993-1994 Contributing Editor, UCSF School of Dentistry Faculty Development Newsletter 1993-1995 Member, Faculty Development Committee, UCSF School of Dentistry 1993-1994 Member, Organizing Committee for Symposia on "Dentistry in the Age of DNA: The Practical use of DNA Technology in Clinical Dentistry" 1994-1995 Member, Faculty Search Committee, Division of Periodontology, Department of Stomatology, UCSF 1995-1997 Member, Academic Planning and Budget Committee, School of Dentistry, UCSF 1995-1997 Member, Search Committee for Chair of Division of Orthodontics, Department of Growth and Development, UCSF 1995-1997 Co-Chair, Curriculum Committee, Division of Orthodontics, Department of Growth and Development, UCSF 1995 Member, Search Committee for Graduate Program Director in Periodontics, UCSF 1995-2002 Member, Clinic Modernization Committee, UCSF School of Dentistry Chair, Clinics Floor Configuration and Clinic Location Subcommittee 1996-2004 Member, Postgraduate Education Coordinating Committee, UCSF School of Dentistry 1996-1997 Member, Search Committee, Clinic Director, Division of Orthodontics, Department of Growth and Development, UCSF 1996-1997 Member, Continuing Dental Education Advisory Committee, UCSF School of Dentistry 1996-1998 Member, Comprehensive Oral Health Research Center of Discovery Planning Committee 1997-2004 Member, Admissions Committee, Graduate Group in Oral Biology 1998-1999 Member, Dean’s Committee on Mission Bay 16 17

1998-1999 Member, Clinical Training Task Force 2000-2004 Member, Search Committee for Chair, Department of Growth and Development 2000-2004 Member, Executive Committee, Graduate Group in Oral Biology, UCSF School of Dentistry 2004-2015 Member, Department Chair’s Committee, School of Dentistry, University of Michigan 2004-2015 Member, Leadership Team, School of Dentistry, University of Michigan 2004 Member, School of Dentistry Renovation/NIH Application Committee, School of Dentistry, University of Michigan 2005 Member, Chair’s Ad Hoc Collections and Billing Office Organization Committee, School of Dentistry, University of Michigan 2006 Member, Strategic Planning School of Dentistry Reorganization Subcommittee, School of Dentistry, University of Michigan 2007 Member, Faculty Funding Committee, School of Dentistry, The University of Michigan 2011-2015 Director, Kenya Summer Research and Outreach Program, School of Dentistry, University of Michigan 2012-2013 Chair, Clinic Efficiencies Committee, School of Dentistry, The University of Michigan 2013-2014 Member, Chief Financial Officer Search Committee, School of Dentistry, University of Michigan 2015-2016 Member, Committee to Promote School of Dentistry Clinical Services, School of Dentistry, University of Michigan 2015-2016 Chair, Educational Advisory Team. R34 Regenerative Medicine Center at University of Michigan. 2016-present Member, Deans and Chairs Executive Group, UCSF School of Dentistry 2017-present Member, Accreditation Steering Committee, UCSF School of Dentistry 2017-present Member, Electronic Health Record Committee, UCSF Dental Center 2017-present Member & Mentor, UCSF Kenya Global Oral Health Program, UCSF School of Dentistry 2018-present Coordinator, Faculty Study Club. UCSF Dental Center 2018-2019 Chair, Image Storage, Access and Applications Task Force, UCSF Dental Center 2018-present Co-chair, Clinical-Discovery Integration Task Force, UCSF School of Dentistry 2018-present Member, Technology Governance Committee, UCSF School of Dentistry 2018-2019 Health System Clinical Practicum Task Force, UCSF School of Dentistry 2019-present Co-chair, Faculty Practice Visioning Task Force, UCSF School of Dentistry 2019-present Dean’s Executive Committee, UCSF School of Dentistry

DEPARTMENT

1988-1990 Member, Admissions Committee, Postgraduate Program in Orthodontics, University of California San Francisco 1990-2003 Chair, Admissions Committee, Postgraduate Program in Orthodontics, University of California San Francisco 1990-1991 Member, Education Policy Committee, Department of Growth and Development, University of California San Francisco 1990-1993 Member, Research Committee, Department of Growth and Development, University of California San Francisco 1991-1992 Member, Faculty Search Committee, Division of Pediatric Dentistry, University of California San Francisco 1991-2004 Member, Faculty Advisory Committee, Department of Growth and Development, University of California San Francisco 1991-1995 Member, Steering Committee, Division of Orthodontics, Department of Growth and Development, University of California San Francisco 1992-1995 Member, Executive Committee, Division of Orthodontics, Department of Growth and Development, University of California San Francisco 1993 Contributing Editor, Orthodontic Newsletter, Division of Orthodontics, Department of Growth and Development, UCSF 1995-1997 Member, Faculty Advisory Committee, Division of Orthodontics, Department of Growth and Development, University of California San Francisco 1996-2000 Member, Clinic Management Committee, Division of Orthodontics, Department of Growth and Development, UCSF

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1996-2000 Chair, Clinic Modernization Committee, Division of Orthodontics, Department of Growth and Development, UCSF 1997-2004 Member, Orthodontics Advisory and Full-time Faculty Committees 1998-1999 Chair, Faculty Search Committee, Division of Orthodontics, Department of Growth and Development, UCSF 2000-2004 Chair, Orthodontic Advisory Committee, Division of Orthodontics, Department of Growth and Development, University of California San Francisco 2000-2003 Chair, Clinic Management Committee, Division of Orthodontics, Department of Growth and Development, UCSF 2002-2004 Member, Faculty Search Committee, Division of Craniofacial Anomalies, Department of Growth and Development, UCSF 2004-2015 Chair, Department of Orthodontics and Pediatric Dentistry Faculty Committee, University of Michigan School of Dentistry 2004-2015 Chair, Orthodontics Full-time Faculty Committee, University of Michigan School of Dentistry 2007-2009 Member, Pediatric Dentistry Administrative Team, University of Michigan School of Dentistry 2010-2016 Director, Advanced Orthodontics Mini-Residency Program, University of Michigan School of Dentistry 2011-2016 Director, Orthodontics Continuing Dental Education, University of Michigan School of Dentistry 2016-2019 Co-Chair, Pediatric Dentistry Chair Search Committee, Department of Orofacial Sciences, UCSF 2016-present Co-Chair, Orthodontic Residents Admissions Committee, Division of Orthodontics, UCSF 2016-present Chair, Full-time Faculty Committee, Division of Orthodontics, UCSF

COMMUNITY / PUBLIC SERVICE

1979-1980 Class President, University of Nairobi Dental School 1981-1984 President, Hindu Youth. A charitable organization in Nairobi, Kenya 1997-2009 Organizer of UCSF – Kenya Continuing Dental Education Program (Lecture presentations by Dr. Ib Nielsen, 10/98; External Examiner and lecture by Dr. Amr Moursi 6/02; Sunil and Yvonne Kapila, 7/03; Sunil Kapila, 12/07, 12/09) 2010-2015 Kenya Summer Research and Outreach Program

CONTRIBUTIONS TO DIVERSITY

With my background as a first-generation college graduate from an economically disadvantaged background, and growing up as a minority in Kenya, I am highly sensitive to and supportive of diversity and inclusiveness in all its forms. At the University of Michigan, this strong belief led to a transformed Department from about 30% female full-time faculty to 60% female faculty during my tenure as Department Chair. I have provided substantial hands on mentorship to a diverse cohort of junior faculty, several of who are now in academic leadership positions. In my leadership position at the University of Michigan, we developed and budgeted revenues to provide scholarships to economically disadvantaged students that included first-gens. I have participated in pipeline programs for high school students from under-represented minority communities. We also developed a craniofacial orthodontic fellowship training program and raised over $1 M endowment through the generosity of a grateful parent to serve this underserved and complex patient population. Finally, I initiated and led the dental component of a Kenya Global Oral Health Program at the University of Michigan. A similar program has now been launched at UCSF. This program aims to find sustainable solutions to oral health needs of rural and urban underserved communities in Kenya.

My strong support of and active participation in intellectual diversity and cross-disciplinary collaborations is reflected by several achievements. These include the recruitment of faculty from different institutions and the transdisciplinary programs including the Kenya Summer Research Program (which included faculty and students from the Schools of Medicine, Dentistry, Pharmacy, Nursing and Colleges and Engineering); the compilation of our NIH-funded Institutional Career Development (K12) Award that included faculty from the Schools of Medicine and Dentistry and Public Health, and the College of Literature, Science and Arts; and launching of an interdisciplinary Faculty Study Club at UCSF School of Dentistry. My personal collaborations across clinical areas include those 18 19 with medical, dental and specialty providers in oral maxillofacial surgery, prosthodontics, periodontics and other disciplines, and with faculty from the University of Michigan’s College of Engineering for technology innovation.

TEACHING AND MENTORING

TEACHING SUMMARY

I have been involved in didactic and clinical teaching and research mentorship to a diverse range of student levels including undergraduate (BA) students, dental students, and graduate residents. I have also provided one-on-one mentorship on research and careers to dental and graduate students, postdoctoral scholars and faculty. Besides providing didactic instruction in several areas, I am involved in teaching residents in patient care. Given my background in bone and cartilage biology, my initial didactic instruction focused in this topical area. My interests in physics has led to the development of a comprehensive course in Biomechanics, which I have directed and do most of the teaching in since 1989 both at UCSF and University of Michigan. I also direct and teach a year-long treatment planning course. Additionally, I provide clinical instruction in orthodontics one half day a week, and mentor students on their thesis projects. My teaching both in the classroom and clinics places an emphasis of evidence- based and competency-driven philosophy. I attempt to understand the individual learning styles and pace of comprehension of materials of each student to customize my teaching approaches accordingly. I also seek active engagement and participation of students in their own learning during my didactic, clinical and research instruction. I have co-mentored several dental students in my capacity as the Director of the Kenya Summer Research Program at University of Michigan. In collaboration with Dr. Ben Chaffee we have initiated a similar program for Dental Students at UCSF in which I also serve as a co-mentor. These experiences emphasize experiential learning.

COURSES PRESENTED / DIRECTED

Year Qtr Institution Course Title Units Class Class size 1983 S,F,W Univ of Nairobi Orthodontic Lectures 1 Dent 3 25 1984 W,Sp,S Univ of Nairobi Orthodontic Lectures 1 Dent 4 25 1988 W,Sp,S,F UCSF Orthodontic Seminars 1 Pedo 1 4 1989 Sp UCSF Biomaterials 1 Ortho 1 6 1989 W,Sp,S,F UCSF Orthodontic Seminars 1 Pedo 1 4 1990 F UCSF Ortho Biomaterials 2 Ortho 1 6 1990 W,Sp,S,F UCSF Ortho Diag & Treatment 1 Ortho 1 6 1990 W,Sp,S,F UCSF Ortho Diag & Treatment 1 Pedo 1 5 1990 F UCSF Ortho Biomaterials 2 Ortho 1 6 1991 W, Sp UCSF Ortho Diag & Treatment 1 Pedo 1 5 1991-1995 S,F,W,Sp UCSF Ortho Diagnosis and Treatment Planning 1 Ortho 1 6 1991-1995 S,F,W,Sp UCSF Research Methods 2 Ortho 1 & 2 11 1989-2004 S,F,W,Sp UCSF Treatment in Progress 1 Ortho 1, 2 & 3 15 1991-1994 F UCSF Ortho Biomaterials 2 Ortho 1 5 1991-1993 S,F,W,Sp UCSF Orthodontic Journal Club 1 Ortho 1, 2 & 3 15 1992-2004 W UCSF Principles of Biomechanics 2 Ortho 1 5 1992-2004 Sp UCSF Applied Biomechanics 2 Ortho 1 5 1995-2004 S UCSF Ortho Biomaterials 2 Ortho 1 & 2 10 1995-2004 S,F,W,Sp UCSF Orthognathic Surgery 1 Ortho 1,2 & 3 20 Conference OMFS 1 to 4 1996-2004 S,F,W,Sp UCSF Journal Club 1 Ortho 1,2 & 3 15 1996-2004 S,F,W,Sp UCSF Literature Review 1 Ortho 1,2 & 3 15 2000 Sp UCSF Ortho 121 1 DS 2 80 2004-2015 W,Sp,Su Univ of Michigan Biomechanics of Ortho 2 Ortho 1 7 Materials 2004-2006 W Univ of Michigan Orthodontic Biomaterials 2 Ortho 1 7 2007-2016 S,F,W,Sp Univ of Michigan Treatment in Progress 1 Ortho 1,2 & 3 21 19 20

2017 W,Sp UCSF Biomechanics in Ortho 2 Ortho 1 & 2 10 2017-present W,Sp UCSF Biomechanics in Ortho 2 Ortho 1 5

CLINICAL INSTRUCTION

Year Qtr Institution Clinical Field Units Class Class 1983 S,F,W Univ of Nairobi Orthodontics 12 Dent 3 25 1984 W,Sp,S Univ of Nairobi Orthodontics 12 Dent 4 25 1986-1987 F,W,Sp Univ of Oklahoma Orthodontics 4 Dent 3 & 4 85 1988-1991 S,F,W,Sp UCSF Orthodontics 4 Pedo 1 & 2 4 1989-2004 S,F,W,Sp UCSF Orthodontics 4 Ortho 1, 2 & 3 15 2004-2016 S,F,W,Sp Univ of Michigan Orthodontics 4 Ortho 1, 2 & 3 21 2004-2005 S,F,W,Sp Univ of Michigan Orthodontics 1 Dent 3 80 2016-present W,Sp,S,F UCSF Orthodontics 4 Ortho 1,2 & 3 15

CONTRIBUTIONS TO OTHER COURSES

Year Qtr Course No. & Lecture Title Hours Class Class size 1985 F Univ of Oklahoma Preclinical Laboratory 4 Dent 2 82 1988 F GD 131A: Biomechanics and Biomaterials 1 Dent 3 85 1988 W GD 109: Predoctoral Laboratory 8 Dent 3 20 1989 F GD 131A: Biomechanics and Biomaterials 1 Dent 3 90 1989 W GD 109: Predoctoral Laboratory 8 Dent 3 18 1989 W GD 120: Endochondral & Intramembranous 1 Dent 1 75 Ossification 1989 W GD 120: Craniofacial Growth 1 Dent 1 75 1990 Sp GD 121: Development & Eruption of Permanent 1 Dent1/DH1 100 teeth 1990 Sp GD 121: Establishment of Occlusion 1 Dent1/DH1 100 1990-1995 S Bioactive Molecules of Bone Matrix & Matrix 2 Ortho 1 5-6 Mineralization 1990-1995 S Biochemical & Bioelectric Mediators of 2 Ortho 1 5-6 Mechanically-Induced Bone Remodeling 1990 F GD 120: Osteogenesis & Develop of Craniofacial Skeleton 1 Dent1/DH1 100 1991 Sp GD 121: Development of Occlusion 1 Dent 2/DH1 105 1991-1996 S GD 130.01: Biomechanics 1 Dent 3 90 1991-2000 F GD 120: Intramembranous & Endochondral Ossification and Development of Craniofacial Skeleton 1 Dent 1/ DH 1 90 1991-1994 Sp GD 121: Development and Eruption of Permanent Teeth. Establishment of Occlusion 1 Dent 2 90 1992-2000 Sp GD 121: Development of the Temporomandibular 1 Dent 2 90 Joint 1992-1996 S GD 130.01: Biology of Tooth Movement 1 Dent 3 90 1992-1995 S Morphologic Changes During Tooth and Sutural 1.5 Ortho 1 5 Movement 1992-1996 W GD 131: Orthodontic Biomaterials 1 Dent 3 90 1993-1994 W Restorative Dent 113B: Histopathology of the 1 Dent 1 90 Craniomandibular Articulation 1996 Sp OB 220: Molecular mechanisms for joint degeneration 1 OB Grad 15 students 1997 Sp GD 121: Development of the TMJ 1 Dent 1 85 2005-2012 F LS&A Seminar UC151: The Science and Practice of 1 LS&A 1 15-20 Dentistry in the 21st Century 2017-present Sp Dent Sci 128: Juvenile Idiopathic Arthritis 1 DS2 & IDP1 100 2018 W OCS221: Matrix metalloproteinases in cartilage matrix 2 PhD (BME,OCS) 4 degradation and osteoarthritis 20 21

MENTORING SUMMARY

I have served as a formal or informal research, project and / or career mentor to individuals at various stages of their careers ranging from dental students to junior and senior faculty. Most of the graduate and dental students I have mentored worked with me on their research projects including MS projects. Many of these projects have been published and 15 students/residents have received national research awards from the IADR, AADR and AAO- the latter include three separate recipients of the highest research award given by the AAO. Several of the students and scholars that I have mentored have been funded during their training by NIH-NIDCR grants including an Institutional Career Development (K12) Award on which I was a co-PI. Several of the junior faculty that I have mentored are now funded investigators and / or serve in academic leadership positions.

Predoctoral Students Supervised or Mentored 1986-1987 Shaila Rao, Dental Student at University of Oklahoma: Effect of Cranial Base morphology on facial prognathism. 1989-1990 Stacey Quo, Dental Student at UCSF: A comparison of the validity of bending tests used for evaluating the properties of orthodontic wires. 1992 Miles Guyton and Ms. Lisa Grosso, Dental Students at UCSF: Relationship between wire characteristics in bending tests and bracket - arch wire friction. 1992 Stanley Wong, Dental Student at UCSF: Matrix-degradative response of cultured temporomandibular joint disc cells to cytokines. Supported by NIH-NIDR 5 T35 DE07103-013 1993-1996 Patricia Sing, Dental Student at UCSF: Identification, characterization and regulation of matrix metalloproteinases and inhibitors synthesized by mandibular condylar articular cells. Supported by NIH-NIDR 5 T35 DE07103-014. 1993-1996 Trang Duong, Dental Student at UCSF; Construction of cDNA probes for collagenase, stromelysin, TIMP, TGF-bs and BMP-2. 1994-1995 Romona Yousefipour, Dental Student at UCSF; Modulation of matrix metalloproteinases in mechanically stimulated TMJ disc cells 1996-1997 Michael Anthony, Dental Student at UCSF; Development and calibration of a microprocessor regulated instrumentation for straining skeletal tissues in culture. 1998-1999 Jasmine Gorton, Dental Student at Harvard School of Dental Medicine, 5th year extramural program; Role of integrins in the modulation of collagenase in mechanically stimulated chondrocytes. Supported by NIDR Oral Biology Training Grant. 2000-2003 Loren Jolley, Dental Student at UCSF. Association of bone density with orthodontic root resportion. Supported by NIH-NIDR 5 T35 DE07103. 2001 Natalie Miller, Dental Student at UCSF. Bioengineering a mature TMJ disc. Supported by NIH- NIDR 5 T35 DE07103 2005-2006 Karen Uston, Dental Student at University of Michigan. Relaxin signaling in the regulation of MMPs. Supported by NIDCR Summer Research Program. 2007-2010 Remi Nair, Dental Student at University of Michigan. Relaxin signaling in the regulation of MMPs. Supported by NIDCR Summer Research Program. 2010-2016 Mentored over 20 Dental Students for projects and services rendered as part of the Kenya Summer Research Program.

Postdoctoral Fellows and Residents Mentored 1993-1995 Yue Rao, DDS., MS., PhD., Visiting Assistant Professor and Lee-Heisen Scholar from the Peoples Republic of China. Induction of matrix metalloproteinases and proteinase inhibitors in mechanically loaded fibrochondrocytes and chondrocytes. Presently post-doctoral fellow, Department of Endocrinology, School of Medicine, University of Connecticut 1996-1998 Hu Bo, DDS., PhD., Visiting Assistant Professor from the Peoples Republic of China. Modulation of matrix metalloproteinases by relaxin and estrogen in TMJ synoviocytes, disc cells and ligament cells. 1996-1999 Momotoshi Shiga, DDS., Visiting post-doctoral fellow from Aichi-Gakuin University School of Dentistry. Induction of osteoblastic phenotype in cells retrieved from the periodontal ligament. 1996-1998 Yiqiang Xie, BS, MA., Postgraduate Researcher. Identification of relaxin-inducible elements in the collagenase gene promoter.

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1998-1999 Dr. Julie Huh, DDS., Research Associate. Contribution of relaxin-induced matrix metalloproteinases to altered mechanical properties of lateral and medial collateral ligaments. 2000-2001 Dr. Tabassum Naqvi, PhD. Postodoctoral Fellow. Regulation of fibrocartilaginous matrix degradation via MMPs induced by relaxin and estrogen. 2000-2002 Dr. Madhavee Budhikott, PhD., Postdoctoral Fellow. Mechanisms for hormonal regulation of matrix metalloproteinases in fibrocartilaginous and breast cancer cells. 2001-2004 Dr. Gihan Hashem, MD., MPH., PhD. Postdoctoral Fellow. In vivo changes in cartilaginous tissues to relaxin and bioengineering a TMJ disc. 2002-2015 Dr. Takayuki Hayami, DDS., PhD. Postdoctoral Fellow. The regulation of osteoblast differentiation by matrix metalloproteinases. 2005-2006 Dr. Wanpeng Xu, DDS., PhD. Postdoctoral Fellow. The regulation of osteoclast function by matrix metalloproteinases. 2005-2016 Dr. Jinping Xu, MD. Chondrogenesis in mesenchymal stem cells; Isolation and characterization of multipotent periodontal ligament cells. 2005-2008 Dr. Wei Wang, DDS., PhD. Research Investigator. Hormone-hormone receptor-MMP axis in TMJ degeneration. 2006-2010 Dr. Jeena Joseph, PhD. The effects of fibronectin fragment modulated matrix metalloproteinases on osteoblast differentiation. 2007-2008 Dr. Nika Grigartis, DDS. Identification of progesterone receptor isoforms expressed by TMJ disc and pubic symphysis cells. 2008-2012 Dr. Nisar Ahmad, PhD. Relaxin- and estrogen-mediated signaling in the induction of matrix metalloproteinases. 2008-2016 Dr. Youngnam Park, PhD. Hormone-hormone receptor-MMP axis in TMJ degeneration. 2010-2012 Dr. Jun Hoshomishi, DDS, PhD. Immortalization, cloning and characterization of mouse TMJ disc cells. 2011-2013 Dr. Huang Li, DDS, PhD. Cellular and morphologic characteristics of bone and cartilage in MMP- 9 and -13 null mice. 2013-2014 Dr. Jonah Lee, PhD. Fabrication of three dimensional, multi-phasic, scaffoldless, tissue- engineered temporomandibular joint disc-ligament complex construct (co-mentor). 2013-2016 Dr. Chunxi Ge, MD, PhD. The role of DDR2 in TMJ development and degeneration (co-mentor). 2016-2019 Dr. Songcang Chen, MD, PhD. Deciphering the mechanisms of estrogen and relaxin in enhancing subchondral TMJ bone porosity.

Graduate Students Supervised and M.S. Thesis Chaired 1988-1989 Gary Reichhold, DDS., Orthodontic Resident: Effects of clinical recycling on the mechanical properties of nickel-titanium alloy wires. 1988-1989 Scott Anderson, DDS., Orthodontic Resident: Effects of clinical recycling on the mechanical properties of nickel-titanium alloy wires. 1989-1990 John Haugen, DDS., Orthodontic Resident: Effects of heat and cold sterilization on the bending and tensile properties of nickel-titanium alloy wires. 1990-1992 Howard Freedman, DDS., Orthodontic Resident: Temporomandibular joint loading in asymmetric patients. 1992-1994 Majid Tavakkoli Jou, DDS., Orthodontic Resident and Graduate Student in Oral Biology: Mandibulofacial adaptations in an animal model of juvenile rheumatoid arthritis of the temporomandibular joint. (MS Thesis). 1992-1994 Michael Lyons, DDS., Orthodontic Resident and Graduate Student in Oral Biology: Mechanical induction of TGF-b1 and TGF-b2 in cultured human periodontal ligament cells. (MS Thesis). 1998-1999 Blair Kirk, DDS., Orthodontic Resident and Graduate Student in Oral Biology. Correlative studies on enhanced magnetic resonance imaging and histopathology of temporomandibular joint arthritis. (MS Thesis). Supported by the American Association of Orthodontists. 1998-2000 Meghan O'Connor, DDS., Pediatric Dentistry Resident and Graduate Student in Oral Biology: Mechanically induced expression of TGF-bs in craniofacial sutural explants. (MS Thesis). Supported by the American Association of Orthodontists Foundation. 1998-2001 Elana Peikoff, DDS., Orthodontic Resident and Graduate Student in Oral Biology. Systemic factors associated with temporomandibular disease in women. (MS Thesis). Supported by the American Association of Orthodontists Foundation.

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1995-1997 Melanie Parker, DDS., Orthodontic Resident and Graduate Student in Oral Biology. Modulation by relaxin and beta-estradiol of matrix macromolecules and proteinases in the temporomandibular joint disc. (MS Thesis). 1995-1997 Olivier Collieu, BA, Doctoral Student in Biomedical Engineering. Modulation of intervertebral disc degeneration under mechanical loading. 1996-1999 Trang Duong, DDS., Orthodontic Resident and Graduate Student in Oral Biology. Modulation by relaxin and b-estradiol of proteinases and matrix macromolecules TMJ discs. (MS Thesis) 1997-2000 Tina Vezendy-Reed, DDS., Orthodontic Resident and Graduate Student in Oral Biology. Systemic levels of relaxin, b-estradiol and progesterone in women with TMJ symptoms and asymptomatic controls. (MS Thesis) 1998-1999 Jeffrey Wong, DDS, Orthodontic Resident and Graduate Student in Oral Biology. Differentiation- dependent responses of osteoblasts to mechanical strain (MS Thesis) 1998-2002 Kristen Miller, DDS., Orthodontic Resident and Graduate Student in Oral Biology. Systemic factors associated with TMJ disease in women (MS Thesis) 1998-2002 Jean Chen, DDS., Orthodontic Resident and Graduate Student in Oral Biology. In vivo effects of relaxin on matrix metalloproteinases and matrix macromolecules in the TMJ disc (MS Thesis). 1998-2002 Chad Cassidy, DDS., Orthodontic Resident and Graduate Student in Oral Biology. Is orthodontic root resorption associated with alveolar bone density? (MS Thesis). 2001-2004 Kristy Chung, DMD., The role of female reproductive hormones in TMJ disease in women (MS Thesis). 2001-2004 Paul Rim, DMD., Bioengineering a mature TMJ disc (MS Thesis). 2004-2006 Matt Dunn, DDS., Local delivery of Osteoprogerin as a means of orthodontic anchorage (MS Thesis). 2005-2007 Vivian Chan, DMD., The role of female reproductive hormones in TMJ diseases in women (MS Thesis). 2005-2008 Mindy Greenblatt, DMD., Volumetric Airway Measurements of Pre-orthognathic Cleft Lip and Cleft Palate Patients Using 3D Imaging (MS Thesis). 2006-2010 Paul Hwang, DDS., Non-thermal, superelastic nickel titanium alloy arch-wires reveal distinctly different behavior in a simulated arch form than in a three-point bend test (M.S. Thesis) 2007-2010 Brad Hudson, DDS. Enhancing post-orthodontic stability by local administration of osteoprotegerin (MS Thesis) 2008-2011 Ashwini Joshi, DDS., The effects of IGF-1 and mandibular hyperpropulsion on mandibular growth (MS Thesis). 2009-2011 Devin Johnson, DMD., Effects of Curve of Wilson correction and boundary conditions on quantitative changes in alveolar bone morphology during orthodontic treatment (M.S. Thesis). 2009-2012 Adam Welmerink, DDS., Effects of orthodontic expansion on bone phenotype and morphology. 2009-2012 Sarah Smith, DDS., Enhancing rates of orthodontic tooth movement through local administration of RANKL (MS Thesis). 2009-2012 Dylan Schneider, DDS., Dose and temporal effects of local Osteoprotegerin administration in enhancing post-orthodontic stability (MS Thesis). 2010-2015 Danielle Ward, DDS. Dosing and efficacy of orally delivered osteoprotegerin in preventing post- orthodontic relapse (M.S. Thesis) 2010-2015 Ambre Ehlert, DDS. Biomarkers of orthodontic root resorption. (M.S. Thesis). 2010-2015 Kelly Goeckner, DDS. Characterization of strains on rapid palatal expander. (M.S. Thesis) 2016-2019 Marianne Demirdji, DDS. The role of osteocyte-mediated bone remodeling in TMJ osteoarthritis (M.S. Thesis; co-advisor with Dr. Tamara Aliston) 2017-present Sia Novashadian, DDS. Regulating orthodontic tooth movement via slow release biomolecules (M.S. Thesis)

Thesis Committee Membership 1994 Member, MS Thesis, Ye Ming Wu, DDS., Pediatric Dentistry Resident and Graduate Student in Oral Biology: In vitro characteristics of periodontal ligament fibroblast-like cells from primary teeth. 1996 Member, MS Thesis, Glenn Frial, DDS., Orthodontic Resident and Graduate Student in Oral Biology. Effects of mechanical strain on L6J1 myoblasts. 1998 Member, MS Thesis, Urmi Amin, DDS., Pediatric Dentistry Resident and Graduate Student in Oral Biology.

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2004 Member, PhD Thesis. Katherine Kursa, Graduate Student in Biomedical Engineering. “Mechanical characterization of the flexor tendon” 2004-2017 Member MS Theses: Heather Zablocki, 2005; Laurie McNamara, 2005; Marcus Daeger, 2006; Katherine Swan, 2007; Fatima Ahmed, 2009; Jason Charnley, 2009; Matthew Lineberger, 2011; Inna Sydorak, 2017.

Qualifying Examination Committees 1997 Member, Ph.D. Qualifying Examination Committee, Ms. Erica Whitney in Biomedical Engineering, UCSF 1997 Member, Ph.D. Qualifying Examination Committee, Dr. Chin-Yu Lin in Oral Biology, UCSF 1999 Member, Ph.D. Qualifying Examination Committee, Dr. David Young in Oral Biology, UCSF 2000-2004 Member, Ph.D. Thesis Committee. Ms. Katherine Kursa in Biomedical Engineering, UCSF

PhD Thesis External Examiner 2009 External Examiner, Ph.D. Thesis. Dr. Qian Feng Li, University of Hong Kong. 2011 External Examiner, Ph.D. Thesis. Su Ee Wong. Investigating the Significance of Relaxin in Experimental Diabetic Renal Disease. Florey Neuroscience Institute, Department of Biochemistry and Molecular Biology, University of Melbourne.

Faculty Mentor 2005-2015 Dr. Nan Hatch, DMD, PhD. Assistant Professor, University of Michigan School of Dentistry (currently Chair, Department of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry) 2006-2011 Dr. Sunil Wadhwa, DMD, PhD. Assistant Professor, The University of Connecticut School of Dental Medicine. Mentor on K22 Award. (currently Chair, Department of Orthodontics, Columbia University College of Dentistry) 2007-2010 Dr. Sylvia Frazier-Bowers, DDS, PhD. Assistant Professor, University of North Carolina (currently Assistant Dean for Diversity and Inclusion, University of North Carolina School of Dentistry) 2006-2010 Dr. R. Scott Coley, DMD. Assistant Professor, University of Michigan School of Dentistry (currently Chair, Department of Orthodontics, University of Buffalo, School of Dentistry) 2007-2011 Dr. Zenyang Wang, DDS, PhD. Assistant Professor, University of Michigan School of Dentistry 2011-2013 Dr. Jeanne Nervina, DMD, PhD. Assistant Professor, University of Michigan School of Dentistry 2011-2015 Dr. Lucia Cevidanes, DDS, PhD. Assistant Professor, University of Michigan School of Dentistry 2014-2015 Dr. Noriaki Ono, DDS, PhD. Assistant Professor, University of Michigan School of Dentistry 2014-2015 Dr. Wanida Ono, DDS, PhD, DMSc. Assistant Professor, University of Michigan School of Dentistry 2015-2016 Dr. Sumit Yadav, DDS, PhD. Assistant Professor, University of Connecticut School of Dental Medicine 2017-present Dr. Mona Bajestan, DDS. MS. Assistant Clinical Professor, University of California San Francisco 2018-present Dr. Andrew Jheon, DDS, PhD. Assistant Professor, University of California San Francisco

Student Research Awards 1993 Patricia Sing, Dental Student, University of California San Francisco, Recipient of the 1993 Dean’s Basic Science Research Award. 1996 Blair Kirk, Orthodontics Graduate Student, University of California San Francisco, Recipient of the Award of Special Merit for M.S. Thesis from the American Association of Orthodontists. 1997 Elana Peikoff, Orthodontics Graduate Student, University of California San Francisco, Recipient of the Award of Special Merit for M.S. Thesis from the American Association of Orthodontists. 2000 Trang Duong, Orthodontics Graduate Student, University of California San Francisco, Recipient of the Harry Sicher First Essay Research Award for M.S. Thesis from the American Association of Orthodontists. 2001 Loren Jolley, Dental Student, University of California San Francisco, Recipient of 2001 Dean’s Clinical Research Award and IADR Travel Award. 2005 Kristy Chung, Orthodontics Graduate Student, University of California San Francisco, Recipient of Thomas M. Graber Award of Special Merit for M.S. Thesis from the American Association of Orthodontists. 24 25

2005 Paul Rim, Orthodontics Graduate Student, University of California San Francisco, Recipient of Thomas M. Graber Award of Special Merit for M.S. Thesis from the American Association of Orthodontists. 2005 Karen Uston, Dental Student, The University of Michigan Summer Research Program NIDCR Fellowship. 2006 Mathew Dunn, Orthodontics Graduate Student, The University of Michigan, Recipient of Thomas M. Graber Award of Special Merit for M.S. Thesis from the American Association of Orthodontists. 2008 Wei Wang, Postdoctoral Fellow, The University of Michigan, Recipient of the Sarnat Award from the Craniofacial Biology Group of the International Association for Dental Research. 2008 Remi Nair, Dental Student, The University of Michigan, Recipient of AADR Student Research Award. 2011 Brad Hudson, Orthodontics Graduate Student, The University of Michigan, Recipient, Milo Hellman Award from the American Association of Orthodontists. 2012 Ashwini Joshi, Orthodontics Graduate Student, The University of Michigan, Recipient Milo Hellman Research Award from the American Association of Orthodontists. 2013 Dylan Schneider, Orthodontics Graduate Student, The University of Michigan, Recipient Thomas Graber Research Award from the American Association of Orthodontists. 2014 Sarah Smith, Orthodontics Graduate Student, The University of Michigan, Recipient Thomas Graber Research Award from the American Association of Orthodontists. 2018 Inna Sydorak, Orthodontics Graduate Student, The University of Michigan, Recipient, Milo Hellman Award from the American Association of Orthodontists.

TEACHING AWARDS

1990-1991 Outstanding Teacher of the Year Award, Department of Growth and Development, UCSF

GRANTS FOR TEACHING AIDS

Dynamic Three-Dimensional Instructional Program in Orthodontic Biomechanics. Academic Services Instructional Improvement Project Grant. Total direct costs $1,902; Project period 8/1/1996 to 6/30/1997.

RESEARCH AND CREATIVE ACTIVITIES

RESEARCH AND CREATIVE ACTIVITIES SUMMARY

My work over the past almost three decades has focused on three inter-related research and academic endeavors that have been both fruitful and successful in furthering discoveries through (1) studies in biomedical and technology fields; (2) mentorship of scholars and faculty towards developing the next generation of researchers and leaders in the field; and (3) the transfer of contemporary knowledge and discoveries towards clinical utilization through scientific symposia and publication of proceedings. I have been consistently funded by NIH and other extramural sources for studies focusing on mechanisms for cartilage and bone remodeling, regeneration and degeneration in health and disease that cover a range of conditions and systems including the temporomandibular joint (TMJ), biological modulation of tooth movement and progenitor and stem cell differentiation. These studies utilize both in vivo animal models and in vitro studies to dissect the cellular and molecular basis for skeletal tissue turnover as explained below. In order to create a pipeline of scholars in fields related to our work, over the years I have been involved in the training and career development of students, postdoctoral fellows and faculty. In this regard and given my background and history of funding in temporomandibular joint disorders (TMJD), we have trained scholars in TMJD and Orofacial Pain through an NIH funded Career Development (K12) Award (NIH-NIDCR K12DE023574). Using this mechanism, I co-mentored postdoctoral fellows and a junior faculty member on various projects on TMJ development, pathobiology and regeneration. Success in research and career mentorship is reflected by the fact that 15 individual I mentored or co-mentored received national research awards, and several junior faculty that I have mentored are now independently funded investigators and /or hold leadership positions in their respective institutions. For technology transfer and precision orthodontics, several colleagues and I have organized

25 26 eight biennial conferences and several Moyers Symposia, compiled the latest information in 15 proceedings and monographs, and have been involved in several technological innovations one of which recently received a patent. Early Scientific Contributions During the first part of my career following completion of my dental education, I worked in an environment devoid of any scientific resources, mentorship or technologies in Kenya. Despite these limitations and as a young inexperienced researcher, I embarked on studies of importance that had implications both to dental health professionals and the population in general. My contributions to the knowledge included determining the incidence of hepatitis B in dental professionals (Likimani and Kapila, 1983) that formed the basis for justifying hepatitis B vaccinations, which had just then become available, to oral health care providers. Working with Dr. Firoze Manji, a public health dentist, we established baseline information on the prevalence on fluorosis in Kenya (Manji and Kapila, 1986a, b and c), and I assisted in organizing an international workshop on this topic in Nairobi. These endeavors together led to corporations re-introducing fluoride-free toothpaste in areas of endemic fluorosis and the education of parents against children swallowing toothpaste that would aggravate dental fluorosis. I was also the first to determine the prevalence of malocclusions in Kenyan children (Kapila, 1983) and cephalometric norms in an indigenous group of the Kenyan population (Kapila, 1989). Prior to this work, no such information was available for Kenyans or for any other part of sub-Saharan Africa except South Africa. This early work led to my being awarded a Fulbright Hayes Scholarship to train as an orthodontist in the US. Contributions to Understanding the Pathobiology of TMJ Disorders I embarked on my long-term research endeavors to unravel the pathologic, diagnostic and therapeutic challenges in the poorly understood area of TMJD during my PhD studies at UCSF. Working with colleagues and my PhD mentor Dr. David Richards, we developed and characterized the first reproducible animal model of inflammatory TMJ disease (Kapila et al., 1995a). We were also the first to document the mandibulofacial growth changes in juvenile rheumatoid arthritis (JRA)-like disease of the TMJ in this animal model (Tavakkoli et al., 1999). This model has since been used by others to test the efficacy of new therapeutic regimens to minimize the adverse effects JRA of the TMJ. We also were the first to characterize the matrix metalloproteinases (MMPs) expressed by temporomandibular joint cells (Kapila et al., 1995b), which has formed the foundation of subsequent work by our laboratory and several other investigators in deciphering the regulation of TMJ development, disease progression and markers of disease. Besides the original publications in this field cited above, some of our initial work in TMJDs is summarized in two chapters (Kapila and Trosien, 1996; Kapila,1997). One of my group’s other key contributions during this time was the investigation and validation of a novel sensitive method to determine the presence and severity of inflammatory joint disease using a newly introduced high molecular weight contrast agent in conjunction with dynamic magnetic resonance imaging (MRI). Working with colleagues in UCSF’s Department of Radiology, we showed that the change in post-contrast signal intensity over time in inflamed TMJs and knee joints was highly correlated with the severity of joint inflammation (Demsar et al., 1996; van Dijke et al., 1997, 1999). This work is the basis of a standard sensitive diagnostic procedure now routinely used to determine the presence and severity of arthritis. The main focus of our lab’s current studies is to elucidate the role of female sex hormones in contributing or predisposing to TMJDs. This line of inquiry is based on the fact that degenerative TMJDs have a high female to male predilection. Furthermore, TMJDs have an early onset in women during reproductive years as opposed to similar degenerative conditions in systemic joints that largely afflict postmenopausal women. Because of these reasons, our laboratory is elucidating the contribution and mechanisms of action of estrogen- and relaxin-induced MMPs to the targeted degradation of TMJ fibrocartilage. Our long-term goal is to delineate rationale preventive strategies or therapies for degenerative joint diseases of the TMJ. For these studies, we have performed in vitro and in vivo studies demonstrating that both relaxin and estrogen cause a targeted dose-dependent induction of specific MMPs in TMJ fibrocartilage (Kapila and Xie, 1998; Kapila, 2003; Kapila et al., 2009b; Kapila et al., 2013; Ahmad et al., 2018; Park et al., 2019) that leads to the loss of collagen and glycosaminoglycans (Naqvi et al., 2005; Hashem et al., 2006; Park et al., 2019). Progesterone attenuates the induction of MMPs and matrix loss by relaxin and estrogen. The changes in matrix composition in TMJ fibrocartilage by these hormones is similar to that observed in the pubic symphysis and differs from that of the knee meniscus; the latter tissue does not show any changes in its matrix composition on hormonal stimulation. Our lab has also found that the two target tissues showing the greatest modulation of MMPs and matrix loss, namely the TMJ disc and pubic symphysis, have similar expression profiles of the estrogen receptors (ER)-a and -b, and the relaxin receptors, relaxin family peptide (RXFP)-1 and -2 that differed substantially from those in cells from the knee meniscus (Wang et al., 2009; Kapila et al., 2009a). We also showed that relaxin’s induction of MMP-9 and -13 26 27 is mediated via RXFP1 but not RXFP2 (Ahmad et al., 2012), while estrogen modulates MMP-9 and -13 expression by signaling via ER-a but not ER-b (Ahmad et al., 2018). (Supported by NIH R29 DE11993, K02 DE00458 and R01 DE018455). Our lab is currently dissecting the contribution of MMP-9 and -13 to the in vivo loss of matrix molecules by relaxin or estrogen in the TMJ using MMP-null mice (Park et al., 2019). In vivo studies are also ongoing to determine the contribution of RXFP1 and ER-a, respectively, to relaxin- and estrogen-mediated degradation of disc matrices. Towards addressing some of the goals of these studies, we have isolated, cloned and immortalized TMJ disc cells (Park et al., 2015) that are a highly valuable resource in studying the mechanisms of TMJ cell responses to exogenous stimulants and, because of their multipotent differentiation capacity, could prove to be useful in tissue engineering of the TMJ. Two of the disc cell clones have been licensed to a commercial enterprise (Applied Biological Materials, Inc). Together these findings suggest a novel model for targeted tissue turnover of TMJ fibrocartilage through hormone-mediated induction of select MMPs via specific hormone receptors and cell-type specific responses. These are the first studies to identify the presence of relaxin receptors in TMJ fibrocartilage, and the first in the field of estrogen and relaxin biology to show that these hormones regulate MMPs via ER-a and RXFP1, respectively. Our work has also established the specificity and basis for differences between knee and TMJ cartilage degeneration mediated by estrogen and relaxin. These findings point towards possible therapeutic targets for mitigating the adverse effects of hormones on TMJ tissues. Some of this work is also summarized in two review articles (Kapila, 2003; Wadhwa and Kapila, 2008). Other Contributions to Science 1. MMP- and Mechano-Regulation of Progenitor / Stem Cell Differentiation in Bone and Cartilage: Our lab has also determined the contribution of MMP-1 and -13 in bone degeneration in periodontal disease, with potential applications to conditions such as osteoarthritis, osteoporosis and osteopenia. We have identified a critical role of MMP-1 and -13 in inhibiting osteoblast differentiation of progenitor cells, which by decreasing the pool of osteoblasts available for bone regeneration, may perpetuate ongoing osteolysis (Shiga et al., 2002; Hayami et al., 2007 and 2011; Joseph et al., 2010). Conversely, we have shown that MMP-1 and -13 inhibition enhances osteoblast differentiation of osteogenic cells that has potential applications to bone regeneration and tissue engineering (Hayami et al., 2007 and 2011). Additional studies have characterized growth factor-mediated and mechano- mediated differentiation of progenitor cells into chondrocytes (Yoneno et al., 2005; Xu et al., 2008b; Haudenschild et al., 2008). Working with collaborators in orthopedic surgery at UCSF, we have provided the first in depth characterization of gene regulation in stem cells undergoing chondrogenic differentiation (Xu et al., 2008b). Our laboratory has also isolated and characterized progenitor cells from the periodontal ligament and TMJ disc for use in regenerative therapies (Xu et al., 2008b; Park et al., 2015) and, working with collaborators, determined the role of PDL progenitor cells in in vivo cementogenesis (Paula-Silva, 2010). (Supported by NIH-NIAMS R01 AR49786 and NIH-NIDCR R01 DE016671 and R01 DE018455). 2. Biomodulation of Tooth Movement and Root Resorption in Orthodontic Therapy: In a series of animal studies, we have examined the potential efficacy of (a) osteoprotegerin (OPG) in minimizing tooth movement for orthodontic anchorage or post-orthodontic retention (Dunn et al., 2007; Hudson et al., 2012; Schneider et al., 2015, Sydorak et al., 2018), and (b) RANKL to expedite tooth movement (Smith et al., in preparation). Studies using OPG have progressed from submucosal high dose multiple injections of OPG to prevent unwanted tooth movement to a single low dose injection with minimal systemic effects of the drug. Current studies are focused on determining the efficacy of time-release low dose delivery of OPG to prevent relapse in rats prior to embarking on human trials. Studies to expedite orthodontic treatment have been performed using RANKL to enhance the rate of orthodontic tooth movement and demonstrated its efficacy for this purpose. These studies, performed by graduate orthodontic students under my mentorship, have won five national research awards from the American Association of Orthodontists. Some of our work in this field is also summarized in a textbook chapter (Kapila and King, 2014). 3. Devise Development for Craniofacial Anomalies and Other Skeletal Defects: Towards developing additional approaches for directionally controlled bone regenerative therapies, I have undertaken projects with colleagues at the University of Michigan’s College of Engineering to develop new devices and instrumentation. Remolding of bone is critical to the normalization of facial structures in patients with craniofacial anomalies and other developmental or acquired craniofacial skeletal dysplasias. In the more severe forms of these conditions, this requires both surgical intervention and the use of mechanical devices or distractors that attempt to relocate bones of the face into more normal relationships. Conventional distractors have several design constraints that prevent ideal, efficient and predictable realignment and normalization of craniofacial bone placement and relationships. This is further complicated by the fact that the craniofacial anatomy, unlike that of other bones, is a highly complex 3D design. Because of the limitations of current devices, we have designed distractors that control force delivery vectors and 27 28 magnitudes in real time in three-dimensions (Supported by FDA F029564; PI: Nervina, J). Towards the goal of 3D printing of custom distractors and other medical / dental devices, my engineering colleagues and I have recently received a patent (Patent # US10,406,750) for a novel fiber-reinforced 3D printing technology that will facilitate the fabrication of patient-specific devices with the desired mechanical properties.

RESEARCH AWARDS - AS PRINCIPAL INVESTIGATOR

Previous Funding Effect of mandibular position on craniomandibular growth. Academic Senate Committee on Research. Total direct costs $7,500; Project period 7/1/1988 to 6/30/1989.

Effect of altered occlusal position of the mandible on craniomandibular growth. UCSF Dental School Biomedical Research Support Grant. Total direct costs $7,700; Project period 7/1/1989 to 6/30/1990.

Extracellular matrix degradative enzymes in temporomandibular joint disease. UCSF Academic Senate Committee on Research. Total direct costs $8,000; Project period 7/1/1989 to 6/30/1990.

Characterization of metalloproteinases and inhibitor regulation by temporomandibular joint fibroblasts, chondrocytes and disc cells. Biomedical Sciences Research Grant, University of California San Francisco Dental School. Total direct costs $8,102.00; Project period 7/1/1990 to 6/30/1991.

Mandibulofacial adaptations in response to juvenile rheumatoid arthritis of the temporomandibular joint. American Association of Orthodontists Research Grant. Total direct costs $14,000; Project period 7/1/1993 to 12/31/1994.

Microprocessor regulated instrumentation for mechanical perturbation of cells. UCSF Academic Senate Shared Equipment Grant. Total Direct Costs $12,000; Project period not applicable.

TGF-bs in Mechanically Induced Bone Modeling. NIH-NIDR 1 P50 DE10306-01; Research Center in Oral Biology. Total direct costs $20,000; Project period 1/1/1993 to 12/31/1994.

Correlative Studies on Enhanced Magnetic Resonance Imaging and the Histopathology of Temporomandibular Arthritis. American Association of Orthodontists Research Grant. Total direct costs $15,000; Project period 7/1/1994 to 12/31/1995.

The Role of Mechanically Induced TGF-bs in Osteoblast Proliferation, Differentiation and Bone Matrix Turnover. NIH-NIDR 1 P50 DE10306-03; Research Center in Oral Biology. Total direct costs $10,000; Project period 1/1/1995 to 12/31/1996.

Mechanically Induced Expression of TGF-bs in Craniofacial Sutural Explants. American Association of Orthodontists Foundation Biomedical Research Grant. Total direct costs $15,000; Project period 7/1/1994 to 12/31/1996.

Load-induced Matrix Degradative Activity in Temporomandibular Joint Chondrocytes and Fibrochondrocytes. University of California Orthodontic Alumni Foundation. Total direct costs $8,000; Project period 1/1/1995 to 6/1/1996.

The Role of the Hormone Relaxin in Temporomandibular Joint Disease in Women. American Association of Orthodontists Foundation Biomedical Research Grant. Total direct costs $15,000; Project period 7/1/1995 to 12/31/1996.

Modulation of osteoblast activity and bone remodeling by mechanical strain. American Association of Orthodontists Foundation Biomedical Research Grant. Total direct costs $15,000; Project period 7/1/1996 to 12/31/1997.

The Role of the Hormone Relaxin in Temporomandibular Joint Disease in Women. University of California Orthodontic Alumni Foundation. Total direct costs $6,825; Project period 5/1/1997 to 4/30/1998.

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Cellular and molecular pathophysiology of root resorption during orthodontic tooth movement. American Association of Orthodontists Foundation Biomedical Research Grant. Total direct costs $15,000; Project period 7/1/1997 to 6/30/1999.

Mechanisms for transduction of mechanical loading into bone degradative gene expression. American Association of Orthodontists Foundation Biomedical Research Grant. Total direct costs $15,000; Project period 7/1/1998 to 12/31/1999.

Tunable Microplate Spectrofluorometer. UCSF Academic Senate Shared Equipment Grant. Total costs $25,000. Project period 3/1/00 to 9/30/00.

Modulation of TMJ Degradation by Relaxin and Estrogen. NIH-NIDCR 1R29DE11993. Total Annual Direct Costs for 05 grant year $74,886; Project period 9/15/1996-9/14/2001.

Characterizing the role of estrogen and relaxin receptors in TMJ disc degradation. American Association of Orthodontists Foundation Biomedical Research Grant. Total direct costs $15,000; Project period 7/1/2000 to 12/31/2001.

Structure Function Relationships within the Temporomandibular Joint. NIH-NIAMS Multipurpose Arthritis and Musculoskeletal Disease Center P60-AR20684 (Center Principal Investigator, Dr. David Woofsy). Project co-PI with Dr. Jeffrey Lotz. Total annual direct costs $43,090; Project period 1/1/01-12/31/02.

Predicting load-induced degradation of the TMJ disc through finite element modeling. American Association of Orthodontists Foundation Biomedical Research Grant. Total direct costs $15,000; Project period 7/1/2001 to 12/31/2002.

Craniofacial Imaging in the 21st Century. NIH / NIDCR 1 R13 DE014919-01 (Conference Grant). Total annual direct costs $23,000; Project period 8/1/2002 to 7/30/2003.

The role of female reproductive hormones in the etiopathogenesis of TMJ disease. NIH-NIDCR P60 DE13058. Comprehensive Oral Health Research Center for Discovery (Center Principal Investigator, Dr. Caroline Damsky). Total annual direct costs $72,000; Project period 7/1/1999 to 6/30/2004 (No cost extension to 6/30/05).

Female reproductive hormones in TMJ diseases. NIH General Clinical Research Center M01 RR00079 (Center Principal Investigator, Dr. Haile Debas) Total annual direct costs approximately $45,000; Project period 1/1/2000 to 12/31/2005.

Modulation of TMJ degradation by relaxin and estrogen. NIH-NIDCR 1 K02 DE00458 (Independent Scientist Award). Total annual direct costs $90,000; Project period 4/1/2000 to 3/31/2005.

Mesenchymal stem cells and mechanoplasticity. NIH-NIAMS R01 AR 49786-01(Co-PIs, Dr. Jeffrey Lotz and Sunil Kapila). Total annual direct costs $176,000; Project period 7/1/2005 to 6/30/2009.

Craniofacial Skeletal Tissue Engineering Technology Transfer Symposium. NIH-NIDCR 1R13 DE 016253. (PI, S. Kapila). Total annual direct costs $23,000; Project period 7/1/2004 to 5/30/2009

Fibronectin Fragment-induced Osteolysis Mediated by MMPs. NIH-NIDCR R01 DE016671-01. (PI, S. Kapila) Total annual direct costs $237,500; Project period 4/1/05 to 3/31/11.

Hormone-Receptor-MMP Axis in Degenerative TMJ Diseases. NIH-NIDCR R01 DE018455 (PI, S. Kapila) Total annual direct costs $242,500; Project period 9/1/07 to 6/30/14.

University of Michigan’s TMJD and Orofacial Pain Interdisciplinary Consortium (UM-TOPICs). NIH-NIDCR K12DE023574 (PI, S. Kapila; D. Clauw). Total annual direct cost $494,698; Project period 7/1/13 to 6/30/19.

Current Funding

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The Role of Osteocyte-mediated Bone Remodeling in TMJ Osteoarthritis. American Association of Orthodontists Foundation. Total annual direct cost $30,000; Project Period 7/1/18 to 6/30/20.

Educational Innovation in Orthodontics: A Novel Multicenter Faculty Career Enrichments in Orthodontics (FACEs in Orthodontics) Consortium. American Association of Orthodontists Foundation. Total annual direct costs $49,500; 7/1/19 to 6/30/23.

Applications Pending Review or Funding None

RESEARCH AWARDS - AS CO-INVESTIGATOR

Previous Funding Animal models for TMJ dysfunction. UCSF Dental School Biomedical Research Support Grant. Principal Investigator, Rich Kao. Total direct costs $6,000; Project period 7/1/1988 to 6/30/1989.

Effect of Mandibular Position on Craniomandibular Growth in the Rabbit. NIH-NIDR, 1 R03 DE08987-01A1. Principal Investigator, Arthur J. Miller. Total direct costs for 01 grant year $22,000; Project period 3/1/1990 to 2/28/1991.

Specialized microscope for examination of thick sections. UCSF Academic Senate Shared Equipment Grant. Principal Investigator, Dr. Pamela DenBesten. Total Direct Costs $15,375; Project period not applicable.

Relaxin and estrogen in the etiopathogenesis of TMJ disease. NIH-NIDCR Comprehensive Oral Health Research Center for Discovery Planning Grant (Center Principal Investigator, Dr. Caroline Damsky). Total direct costs $100,000; Project period 7/1/1997 to 12/31/1998.

Institutional Dentist Scientist Award. NIH-NIDCR. Principal Investigator, Dr. Grayson Marshall. Project period 7/1/1996 to 6/31/2000.

Oral Biology Training Grant. NIH-NIDCR T32 DE07204. Principal Investigator, Dr. Caroline Damsky. Project period 1/1/95-12/31/00.

Institutional Dentist-Scientist Training Program. NIH-NIDCR. Principal Investigator, Dr. Grayson Marshall. Project period 7/1/1996 to 6/31/2001.

Craniofacial Anomalies Training Grant. NIH-NIDCR. Principal Investigator, Dr. Arnold Kahn. Project period 9/1/96 to 8/30/2001.

COHORT Training Grant. NIH-NIDCR. Principal Investigator, Dr. Grayson Marshall. Project period 9/1/2001 to 8/30/2006.

K12 Career Development Grant. NIH-NIDCR. Principal Investigator, Dr. John Greenspan. Project period 6/1/2002 to 5/31/2007.

Laser effects on dental hard tissues. NIH-NIDCR. Principal Investigator, Dr. John Featherstone. Total annual direct costs $225,000; 8/1/2004 to 7/30/2009 (departed UCSF prior to initiation of this project).

Smart Rapid Palatal Expander for Pediatric Cleft Lip and Palate Patients. FDA F029564, Principal Investigator, Dr. Jeanne Nervina. Health and Human Services, Department of Food and Drug Administration. Total annual direct costs $300,000; 9/15/2011 to 08/31/2013.

Imaging and Biological Markers of TMJ Osteoarthritis. Principal Investigator, Cevidanes, L. American Association of Orthodontists Foundation. Total annual direct costs $25,000; 7/1/12 to 6/30/14.

Quantification of 3D Bony Changes in Temporomandibular Joint Osteoarthritis. NIH-NIDCR R01-DE024450-01. Principal Investigator, Cevidanes, L. Total Annual Direct Costs $303,499; Project Period: 7/1/13 to 30 31

6/30/17. (Terminated my role on this project on moving to UCSF on April 1, 2016)

Educational Innovation in Orthodontics: A Novel Multicenter Faculty Career Enrichments in Orthodontics (FACEs in Orthodontics) Consortium. Co-Principal Investigators: Conley, RS., Kapila, S. American Association of Orthodontists Foundation. Total annual direct costs $49,775; 7/1/12 to 6/30/15.

Educational Innovation in Orthodontics: A Novel Multicenter Faculty Career Enrichments in Orthodontics (FACEs in Orthodontics) Consortium. PI: Conley, RS. American Association of Orthodontists Foundation. Total annual direct costs $50,000; 7/1/15 to 6/30/19.

Current Funding

Consortium for Orthodontic Advances in Science and Technology Innovators' Workshops on "Personalized and Precision Orthodontic Therapy" PI: Nickel, J. American Association of Orthodontists Foundation. Total annual direct costs $37,500; 7/1/15 to 6/30/20.

Applications Pending Review or Funding

The Mechanistic Control of Bone Quality and Joint Crosstalk by Osteocytes. NIH R01 DE019284. Principal Investigator, Alliston, T. Project Period 1/1/2020 to 12/31/2024. Role: Co-investigator

PATENTS AND LICENSES ISSUED OR PENDING

2019 Kapila, S., Park, YN.: Immortalized mouse temporomandibular joint disc cell clones with multi-lineage differentiation capacity. UM Invention Report #6969. Licensed to Applied Biological Materials, Inc.

2019 Barton, K., Kapila, S., Tse, LYL. Fiber Reinforced 3D Printing. Provisional patent #62/370,938; 15/669,441; PCT/US2017/45570; US2018/0036946 A1. Patent # US10,406,750; Sept 10, 2019.

ARTICLES AND PUBLICATIONS

PEER REVIEWED ORIGINAL ARTICLES AND REVIEWS

1983 Kapila, S.*: Distribution of malocclusions in African and Asian children in some Nairobi schools. Odontostomatologie Tropicale, VI:131-137.

1985 Likimani, S. and Kapila, S.: Hepatitis B virus and dental practice. Medicus, 4:21-25.

1986 Manji, F. and Kapila, S.: Fluorides and fluorosis in Kenya. Part I: The occurrence of fluorides. Odontostomatologie Tropicale, IX:15-20.

1986 Manji, F. and Kapila, S.: Fluorides and fluorosis in Kenya. Part II: The occurrence of dental and skeletal fluorosis. Odontostomatologie Tropicale, IX:71-75.

1986 Manji, F. and Kapila, S.: Fluorides and Fluorosis in Kenya. Part III: Fluorides, fluorosis and dental caries. Odontostomatologie Tropicale, IX:135-139.

1988 Meng, H.P., Goorhuis, J., Kapila, S. and Nanda, R.S.: Growth changes in the nasal profile from 7 to 18 years. American Journal of Orthodontics and Dentofacial Orthopedics, 94:317-326.

1988 Kapila, S.* and Currier, G.F.: Hydrochloric acid-pumice treatment for post-orthodontic localized decalcification. American Journal of Dentistry, 1:15-19.

1989 Kapila, S.*: Selected cephalometric angular norms in Kikuyu children. Angle Orthodontist, 59:139-144.

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1989 Kapila, S.* and Sachdeva, R.: Mechanical properties and clinical applications of orthodontic wires. American Journal of Orthodontics and Dentofacial Orthopedics, 96:100-109. (see below for translations into Portuguese, German and Spanish)

1990 Nanda, R.S., Meng, H.P., Kapila, S., and Goorhuis, J.: Growth changes in soft tissue profile. Angle Orthodontist, 60:177-190.

1990 Kapila, S.,* Angolkar, P., Duncanson, M., and Nanda, R.S.: Evaluation of friction between edgewise stainless steel brackets and orthodontic wires of four alloys. American Journal of Orthodontics and Dentofacial Orthopedics, 98:117-126.

1990 Angolkar, P., Kapila, S., Duncanson, M., and Nanda R.S.: Evaluation of friction between ceramic brackets and orthodontic wires of four alloys. American Journal of Orthodontics and Dentofacial Orthopedics, 98:499-506.

1991 Curtis, D.A., Nielsen, I.L., Kapila, S., and Miller, A.J.: Adaptability of the adult primate craniofacial complex to asymmetrical lateral forces. American Journal of Orthodontics and Dentofacial Orthopedics, 100:266-273.

1991 Kapila, S.,* Reichhold, G.W., Anderson, R.S., and Watanabe, L.G.: Effects of clinical recycling on the mechanical properties of nickel-titanium alloy wires. American Journal of Orthodontics and Dentofacial Orthopedics, 100:428-435.

1992 Zylinski, C.G., Nanda, R.S., and Kapila, S.: Analysis of soft tissue facial profile in white males. American Journal of Orthodontics and Dentofacial Orthopedics, 101:514-518.

1992 Kapila, S.,* Haugen, J.W., and Watanabe, L.G.: Load-deflection characteristics of nickel-titanium alloy wires following clinical recycling and dry-heat sterilization. American Journal of Orthodontics and Dentofacial Orthopedics, 101:120-126.

1992 Curtis, D.A., Kapila, S., Curtis, T., Miller, A.J., and Nielsen, I.L.: Vertical dimension increases in the adult rhesus monkey: A pilot study. Journal of Prosthetic Dentistry, 67:701-7.

1995 Kapila, S.,* Lee, C., and Richards, D.W.: Characterization and identification of proteinases and proteinase inhibitors synthesized by temporomandibular joint disc cells. Journal of Dental Research, 74:1328-36.

1995 Kapila, S.,* Lee, C., Tavakkoli-Jou, M., Miller, A.J., and Richards, D.W.: Development and histologic characterization of an animal model of antigen-induced arthritis of the juvenile temporomandibular joint. Journal of Dental Research, 74:1870-9.

1996 Kapila, Y.L., Kapila, S., and Johnson, P.W.: Fibronectin and fibronectin fragments modulate the expression of proteinases and proteinase inhibitors in human periodontal ligament cells. Matrix Biology, 15:251-261.

1996 Demsar, F., van Dijke C.F., Kirk, B.A., Kapila, S., Peterfy, C.G., Roberts, T.P.L., Shames, D.M., Mann, J., and Brasch, R.C.: Mapping abnormal synovial vascular permeability in temporomandibular joint arthritis in the rabbit using MRI. British Journal of Rheumatology, 35:23-25.

1997 van Dijke, C., Kirk, B.A., Peterfy, C., Genant H.K., Brasch, R.C., and Kapila, S*.: Albumin-(Gd-DTPA)30- enhanced MR imaging parameters correlate with histopathology of the arthritic temporomandibular joint. Radiology, 204:825-832. (also published as a chapter in van Dijke, C.F. Ph.D. Dissertation, drukkerij Groenenvelt bv Landgraaf, The Netherlands. pp:115-139)

1998 Kapila, S.,* Xie, Y.: Targeted induction of collagenase and stromelysin in unprimed and b-estradiol- primed temporomandibular joint fibrocartilaginous cells but not in synoviocytes. Laboratory Investigation, 78:925-938.

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1999 Tavakkoli Jou M., Miller A.J., Kapila, S*.: Mandibulofacial adaptations in a juvenile animal model of temporomandibular joint arthritis. Journal of Dental Research, 78:1426-1435.

1999 Quintero, J.C., Trosien, A., Hatcher, D., Kapila, S*.: Craniofacial imaging: Historical perspectives, current status and future developments. Angle Orthodontist, 69:491-506.

1999 van Dijke, C.F., Peterfy, C.J., Brasch, R.C., Lang, P., Roberts, T.P.L., Shames, D., Kneeland, J.B., Lu, Y., Mann, J.S., Kapila, S., Genant, H.K.: MR imaging of the arthritic knee joint using albumin-(Gd-DTPA)30 with correlation to histopathology. Magnetic Resonance Imaging. 17:237-245. (also published as a chapter in van Dijke, C.F. Ph.D. Dissertation, drukkerij Groenenvelt bv Landgraaf, The Netherlands. pp:151-171)

2000 Hu, B., Kapila, Y.L., Budhikott, M., Shiga, M., Kapila, S*.: Coordinate induction of collagenase-1, stromelysin-1 and urokinase plasminogen activator (uPA) by the 120-kDa cell-binding fibronectin fragment in fibrocartilaginous cells: uPA contributes to activation of procollagenase-1. Matrix Biology. 19:657-669.

2002 Huynh, Q.N., Wang, S., Tafolla, E., Gansky, S.A., Kapila, S., Armitage, G., Kapila, Y.L.: Specific fibronectin fragments as markers of periodontal disease. Journal of Periodontal Research 73:1101-1110.

2002 Shiga M., Kapila, Y.L., Zhang, Q., Hayami, T., Kapila, S*.: Ascorbic acid induces collagenase-1 in human periodontal ligament cells but not in MC3T3-E1 osteoblast-like cells: Potential association between collagenase expression and changes in alkaline phosphatase phenotype. Journal of Bone and Mineral Research 18:67-77.

2003 Kapila, S., Sachdeva, R.C.L., Hannam, A.G., Farman, A.G.: Discussions and recommendations of breakout sessions. Proceedings of Conference on Craniofacial Imaging in the 21st Century. Orthodontics and Craniofacial Research, 6 (S 1): 179-182.

2003 Kapila, S.: Does the relaxin, estrogen and metalloproteinase axis contribute to degradation of TMJ fibrocartilage? Journal of Musculoskeletal and Neuronal Interactions. 3:401-405

2004 Tanimoto, K., Ohin., S., Imada, M., Honda, K., Ohno-Nakahara, M., Kapila, S., Tanne, K.: Utility of urinary pyridinoline and deoxypyridinoline ratio for diagnosis of osteoarthritis at temporomandibular joint. Journal of Oral Pathology and Medicine. 23:218-23.

2005 Naqvi, T., Duong, T., Hashem, G., Shiga, M., Zhang, Q. and Kapila, S*: Relaxin’s induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants. Arthritis Research and Therapy. 7:R1-R11.

2005 Tanaka, N., Ohno, S., Honda, K., Tanimoto, K., Doi, T., Ohno-Nakahara, M., Tafolla, E., Kapila, S., Tanne, K.: Cyclic mechanical force regulates the PTHrP expression in cultured chondrocytes via activation of the Ca2+ channel . Journal of Dental Research. 84:64-68.

2005 Yoneno, K., Ohno S., Tanimoto, K., Honda, K., Tanaka, N., Doi, T., Kawata, T., Tanaka, E., Kapila, S. and Tanne, K. Multi-differentiation potential of mesenchymal stem cells in three-dimensional collagen gel cultures. Journal of Biological Materials Research 75:733-41.

2006 Hashem, G., Zhang, Q., Hayami, T., Chen, J., Wang W., and Kapila, S.*: Relaxin and b-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: Progesterone prevents matrix loss. 2006; Arthritis Research and Therapy, Published online 19 June, 2006; 8:R98. (http://arthritis- research.com/content/8/4/R98).

2006 Jolley, L, Majumdar, S., Cassidy, C., Kapila, S.*: Technical factors affecting fractal analysis of periapical radiographs. Dentomaxillofacial Radiology, 2006; 35:393-397.

2007 Hayami, T., Zhang, Q., Kapila, Y., and Kapila, S.*: Dexamethasone enhances specific markers of osteoblastic differentiation in human periodontal ligament cells by inhibiting collagenase expression. Bone, 2007; 40:93-104.

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2007 Dunn, MD., Park, CH., Kosteniuk, PJ., Kapila S.,^ and Giannobile, WV.^: Local delivery of osteoprotegerin inhibits mechanically mediated bone modeling in orthodontic tooth movement. Bone, 41:446-455.

2008 Xu, J., Wang, W., Ludeman, M., Cheng, K., Hayami, T., Lotz, J., Kapila, S.*: Chondrogenic differentiation of mesenchymal stem cells in 3-dimensional alginate gels. Tissue Engineering. Part A. 14:667-680.

2008 Wadhwa, S., Kapila, S.*: TMJ Disorders: Future innovations in diagnostics and therapeutics. Journal of Dental Education. 72:930-947.

2008 Haudenschild, A., Hsieh, AH., Kapila, S., Lotz, JC.: Pressure and distortion regulate human mesenchymal stem cell differentiation. Annals of Biomedical Engineering. 37:492-502. Epub http://dx.doi.org/10.1007/s10439-0080-9629-2.

2008 Hayami, T., Kapila, Y., Kapila, S.*: MMP-1 (Collagenase-1) and MMP-13 (Collagenase-3) differentially regulate markers of osteoblastic differentiation in osteogenic cells. Matrix Biology. 27:682-92. http://dx.doi.org/10.1016/j.matbio.2008.07.05).

2008 Xu, J., Wang, W., Kapila, Y., Kapila, S.*: Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells. Stem Cell and Development. 18:487-496. Epub http://dx.doi.org/10.1089/scd.2008.0113.

2009 Kapila, S.* Wang, W., Uston, K.: MMP induction by relaxin causes cartilage matrix degradation in target synovial joints: Receptor profiles correlate with matrix turnover. Annals New York Academy of Sciences. 1160:322-328. Epub doi: 10.1111/j.1749-6632.2009.03830.x.

2009 Wang, W., Hayami, T., Kapila, S.*: Female hormone receptors are differentially expressed in mouse fibrocartilages. Osteoarthritis and Cartilage. 17:646-654. Epub http://dx.doi.org/10.1016/j.joca.2008.09.015.

2009 Kapila, S.,* Xie, Y., Wang, W.: Induction of MMP-1 (collagenase-1) by relaxin in fibrocartilaginous cells requires both the AP-1 and PEA-3 promoter sites. Journal of Orthodontics and Craniofacial Research. 12:178-186. Epub doi: OCR1451 [pii] http://dx.doi.org/10.1111/j.1601.2009.01451.x.

2010 Joseph, J., Kapila, YL., Hayami, T., Kapila, S.*: Disease-associated extracellular matrix suppresses osteoblastic differentiation of human periodontal ligament cells via MMP-1. Calcified Tissue International, 86: 154-162. Epub http://dx.doi.org/10.1007/s00223-009-9321-z.

2010 Paula-Silva, FWG., Ghosh, A., Higinio Arzate, H., Kapila, S., da Silva, LAB., Kapila., Y. Calcium hydroxide promotes cementogenesis and induces cementoblastic differentiation of mesenchymal periodontal ligament cells in a CEMP1 and ERK-dependent manner. Calcified Tissue International, 87:144-57. Epub 2010 May 4. PubMed PMID: 20440482.

2011 Kapila, S.,* Conley, RS., Harrel, W.: Current status of Cone Beam computed tomography imaging in orthodontics. Journal of Dentomaxillofacial Radiology. 40:24–34. Epub http://dx.doi.org/10.1259/dmfr/12615645.

2011 Hayami, T., Kapila, YL., Kapila, S.*: Divergent upstream osteogenic events contribute to the differential modulation of MG63 cell osteoblast differentiation by MMP-1 (collagenase-1) and MMP-13 (collagenase-3). Matrix Biology, 30:281–289. Epub http://dx.doi.org/10.1016/j.matbio.2011.04.003.

2012 Hudson, JB., Hatch, N., Hayami, T., Shin, JM., Stolina, M., Kostenuik, PJ, Kapila, S*. Local delivery of recombinant osteoprotegerin prevents post-orthodontic relapse. Calcified Tissue International, 90:33-342. doi: 10.1007/s00223-012-9579-4. http://dx.doi.org/10.1007/s00223-012-9579-4

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2012 Ahmed, F., Brooks, SL., Kapila, S*. The efficacy of identifying maxillofacial lesions in cone beam computed tomographs by orthodontists and orthodontic residents. American Journal of Orthodontics and Dentofacial Orthopedics, 141: 451-9. http://dx.doi.org/10.1016/j.ajodo.2011.10.025

2012 Ahmad, N., Wang, W., Nair, R., Kapila, S*. Relaxin induces matrix metalloproteinases-9 and-13 via RXFP1: Induction of MMP-9 involves the PI3K, ERK, Akt and PKC- ζ pathways. Molecular and Cellular Endocrinology, 363:46-61. http://dx.doi.org/10.1016/j.mce.2012.07.006

2012 Ponder, S., Benavides, E., Kapila, S., Hatch, N.: Quantification of external root resorption by low vs. high resolution cone beam computed tomography and periapical radiography: A volumetric and linear analysis. American Journal of Orthodontics and Dentofacial Orthopedics, 143:77-91. http://dx.doi.org/10.1016/j.ajodo.2012.08.023

2013 Kapila, S*., Park, Y., Ahmad, N., Hosomichi, J., Hayami, T., Tacon, C.: Mechanisms for relaxin’s modulation of MMPs and matrix loss in fibrocartilages. Italian Journal of Anatomy and Embryology. 118:62-65.

2014 Cevidanes, LH., Walker, D., Schilling, J., Paniagua, B., Benavides, E., Ludlow, JB., Nackley, A., Rhodes, J., Lim, P., Sugai, J., Nguyen, T., Zhu, H., Baranowski, D., Giannobile, WV., Kapila, S., Styner. M.: 3D osteoarthritic changes in TMJ condylar morphology Correlates with specific systemic and local biomarkers of disease. Osteoarthritis and Cartilage. 22(10):1657-67.

2014 Kapila, S*., Nervina, J.: Cone beam computed tomography in orthodontics: Assessment of treatment outcomes and indications for its use. Dentomaxillofacial Radiology. 44: DOI: 10.1259/dmfr.20140282

2014 Fujawa, D., Tyus, J., Cooper, J., Dzingle, J., Kapila, S., Eber, R., Gonzalez-Cabezas, C., Ndege, PK., Peck, M., Peck, S., and Kapila, Y.: Oral health status of children in rural schools in Kithoka, Kenya. Oral Health and Dental Management. 13:1174-1183.

2014 Kapoor, P., Kharbanda, OP., Miglani, R., Kapila, S.: Effect of orthodontic forces on cytokine and receptor levels in gingival crevicular fluid: A systematic review. Progress in Orthodontics. 15:65-86. doi:10.1186/s40510-014-0065-6.

2015 Iwasaki, LR., Covell, DA. Jr., Frazier-Bowers, SA., Kapila, S., Huja, SS., Nickel JC.: Personalized and precision orthodontic therapy. Orthodontics and Craniofacial Research. 18 (SI):1-7.

2015 Cevidanes, LHS, Gomes, LR., Jung, BT., Gomes, MR., Ruellas, ACO., Goncalves, JR., Schilling, J., Styner, M., Nguyen, T., Kapila, S., Paniauga, B.: 3D superimposition and understanding temporomandibular joint arthritis. Orthodontics and Craniofacial Research. 18(SI):18-28.

2015 Schneider, DA., Smith, SM., Campbell, C., Hayami, T., Kapila S^., Hatch, NE^.: Local limited inhibition of bone resorption and orthodontic relapse by osteoprotegerin protein. Orthodontics and Craniofacial Research. 18(SI):187-195.

2015 Park, Y., Hosomichi, J., Ge, C., Jinping Xu, J., Franceschi, R., Kapila, S*.: Immortalization and characterization of mouse temporomandibular joint disc cell clones with capacity for multi-lineage differentiation. Osteoarthritis and Cartilage. 23(9):1532-42. http://dx.doi.org/10.1016/j.joca.2015.04.006

2015 Kamarajan, P., Hayami, T., Matte, B., Liu, Y., Ramamoorthy, A., Worden, FP., Kapila, S., and Kapila, YL.: Nisin ZP, an bacteriocin and food preservative, inhibits head and neck tumorigenesis and prolongs survival. PLOS One. doi: 10.1371/journal.pone.0131008

2015 Crouch, S., Dzingle, J., Tyus, J., Kapila, S., Eber, R., Ndege, P., Kapila, Y.L.: Oral health status of adults in rural Meru, Kenya. Oral Health and Dental Management. 15:5-13.

2016 Goeckner, K., Pepakayala, V., Nervina, J., Gianchandani, Y, Kapila, S*.: Three-dimensional force measurements during rapid palatal expansion in Sus scrofa. MDPI Micromachines. 7, 64; doi:10.3390/mi7040064 35 36

2016 Lamia, A.F., Aminlari, A., Botero, T., Holland, G.R., Kapila, S., Jin, T., Arzate, H., Kapila, Y.L.: Cellular aging promotes CEMP1 expression in STRO-1 positive PDL cells. International Journal of Oral Science. 3, 276-280. DOI: dx.doi.org/10.19070/2377-8075-1600057

2017 Jheon, AH., Oberoi, S., Solem, RC., Kapila, S.*: Moving towards precision orthodontics: An evolving paradigm shift in the planning and delivery of customized orthodontic therapy. Orthodontics and Craniofacial Research. 20: 106-113. doi: 10.1111/ocr.12171. Review. PubMed PMID: 28643930.

2017 Nickel JC., Covell DA Jr., Frazier-Bowers SA., Kapila S., Huja SS., Iwasaki LR. Preface to COAST 2016 innovators' workshop on personalized and precision orthodontic therapy. Orthodontics and Craniofacial Research. 20 Suppl 1:5-7. doi: 10.1111/ocr.12173. PubMed PMID: 28643915.

2018 Ge, C., Mohamed, F., Binrayes, A., Kapila, S., Franceschi, RT.: Selective role of Discoidin Receptor 2 in the development and ageing of the mouse temporomandibular joint. Journal of Dental Research, 97(3):321-328. doi: 10.1177/0022034517738190. Epub 2017 Oct 26. PubMed PMID: 29073363; PubMed Central PMCID: PMC5833185.

2018 Ahmad N., Chen S., Wang W., Kapila S.* (2018). 17β-estradiol induces MMP-9 and MMP-13 in TMJ fibrochondrocytes via estrogen receptor α. Journal of Dental Research. 97(9):1023-1030. doi: 10.1177/0022034518767108. Epub 2018 Apr 5. PubMed PMID: 29621430; PubMed Central PMCID: PMC6055253. 2018 Sydorak, I., Dang, M., Halcomb, M., Mah, P., Kapila, S., Hatch, N. Microsphere controlled drug delivery for local control of tooth movement. European Journal of Orthodontics. https://doi.org/10.1093/ejo/cjy017 Mar 28. doi: 10.1093/ejo

2019 Almarza, AJ., Mercuri, LG., Arzi, B., Gallo, LM., Granquist, E., Kapila, S. and Detamore, MS. State of TMJ Bioengineering: Working Together Toward Improving Clinical Outcomes. J Biomechanical Engineering. DOI:10.1115/1.4044090

2019 Park, Y., Chen, S., Ahmad, N., Hayami, T., Kapila, S.* Estrogen selectively enhances TMJ disc but not knee meniscus matrix loss. Journal of Dental Research. doi.org/10.1177/0022034519875956

(* = principal and corresponding author; ^ = co-senior and corresponding authors)

OTHER REFEREED ARTICLES AND THESIS

1986 Kapila, S.: Lip Profile Growth Changes: A Longitudinal Cephalometric Study from 7 to 18 Years. M.S. Thesis, University of Oklahoma Health Sciences Center, College of Dentistry.

1994 Kapila, S.: Matrix Metalloproteinases and Proteinase Inhibitors in Antigen-induced Arthritis of the Juvenile Temporomandibular Joint. Ph.D. Dissertation, University of California San Francisco.

BOOKS

2009 Nanda R., Kapila, S. Current Therapy in Orthodontics. Mosby Elsevier. (translated into Spanish, Portuguese and Chinese). http://www.elsevier.com/books/current-therapy-in-orthodontics/nanda/978-0- 323-05460-7

2014 Kapila, S. Cone Beam Computed Tomography in Orthodontics: Indications, Insights and Innovations. Wiley Blackwell, Ames, Iowa. (translated into Chinese) http://www.wiley.com/WileyCDA/WileyTitle/productCd-1118448480.html

PROCEEDINGS

2003 Kapila, S. and Farman, A.G. (editors). Craniofacial Imaging in the 21st Century. Proceedings of the 2002 COAST Conference, Asilomar Conference Center, Pacific Grove, California. Journal of Orthodontics and Craniofacial Research, Munksgaard Press, Copenhagen, Denmark. vol 6; Supplement 1. 36 37

2005 King, G. and Kapila, S. (editors). Craniofacial Skeletal Bioengineering I. Proceedings of the 2004 COAST Conference, Asilomar Conference Center, Pacific Grove, California. Orthodontics and Craniofacial Research, Munksgaard Press, Copenhagen, Denmark. vol 8 (3).

2005 Kapila, S. and King, G. (editors). Craniofacial Skeletal Bioengineering II. Proceedings of the 2004 COAST Conference, Asilomar Conference Center, Pacific Grove, California. Orthodontics and Craniofacial Research, Munksgaard Press, Copenhagen, Denmark. vol 8 (4).

2006 McNamara, JA., Kapila, S. (editors). Digital Radiography and Three-Dimensional Imaging. Craniofacial Growth Series Monograph Number 43, Needham Press, Ann Arbor, Michigan.

2009 McNamara, JA., Kapila, S. (editors). Temporomandibular Disorders and Orofacial Pain. Craniofacial Growth Series Monograph Number 46, Needham Press, Ann Arbor, Michigan.

2009 Covell, D., Frazier-Bowers, S., Hatch, N., and Kapila, S. (editors). Biomedicine in Orthodontics: From Tooth Movement to Facial Growth I. Proceedings of the 2006 COAST Conference, Asilomar Conference Center, Pacific Grove, California. Orthodontics and Craniofacial Research, Munksgaard Press, Copenhagen, Denmark. vol 12 (4).

2009 Covell, D., Frazier-Bowers, S., Hatch, N., and Kapila, S. (editors). Biomedicine in Orthodontics: From Tooth Movement to Facial Growth II. Proceedings of the 2006 COAST Conference, Asilomar Conference Center, Pacific Grove, California. Orthodontics and Craniofacial Research, Munksgaard Press, Copenhagen, Denmark. vol 12 (6).

2010 McNamara, JA., Kapila, S. (editors). Surgical Adjuncts to Orthodontics. Craniofacial Growth Series Monograph Number 47, Needham Press, Ann Arbor, Michigan.

2011 McNamara, JA., Hatch, N., Kapila, S. (editors). Effective and Efficient Tooth Movement. Craniofacial Growth Series Monograph Number 48, Needham Press, Ann Arbor, Michigan.

2015 Kapila, S., Nervina, J.M., Hatch, N. (editors) Expedited Orthodontics: Improving the Efficiency of Orthodontic Treatment Through Novel Technologies. Craniofacial Growth Series Monograph Number 51, Needham Press, Ann Arbor, Michigan.

2015 Covell, Jr. D., Frazier-Bowers, S.A., Huja, S., Iwasaki, L., Kapila, S., Nickel, J. (editors) Personalized and Precision Orthodontic Therapy. Proceedings of the 2014 COAST Innovators’ Workshop, Eaglewood Resort and Spa, Itasca, IL, USA. Orthodontics and Craniofacial Research, Wiley Blackwell, Copenhagen, Denmark. Volume 18 (SI).

2016 Kapila, S., Goonewardene, M. (editors). Interdisciplinary Treatment: Using Contemporary Approaches for Complex Cases. Craniofacial Growth Series Monograph Number 52, Needham Press, Ann Arbor, Michigan.

2017 Kapila, S., Vig, K., Huang, G. (editors). Anecdote, Expertise and Evidence: Applying New Knowledge to Everyday Orthodontics. Craniofacial Growth Series Monograph Number 53, Needham Press, Ann Arbor, Michigan.

2017 Covell, Jr. D., Frazier-Bowers, S.A., Huja, S., Iwasaki, L., Kapila, S., Nickel, J. (editors) Personalized and Precision Orthodontic Therapy. Proceedings of the 2016 COAST Innovators’ Workshop, West Palm Beach, Florida, USA. Orthodontics and Craniofacial Research, Wiley Blackwell, Copenhagen, Denmark. Volume 20 (SI).

CHAPTERS AND OTHER INVITED ARTICLES

1983 Manji, F., and Kapila, S.: Fluorides and Fluorosis in Kenya: An Overview. In Proceedings of Workshop on Fluoride Research Strategies, Nairobi. African Medical Research Foundation, pp:11-21.

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1996 Kapila, S., and Trosien, A.: Pathophysiology and Mandibulofacial Developmental Aberrations in Juvenile Rheumatoid Arthritis of the TMJ. In: Orthodontic Treatment: Management of Unfavorable Sequelae. Craniofacial Growth Series, Monograph Number 31. Eds: McNamara, J.A. and Trotman, C.A. Center for Human Growth and Development, University of Michigan, Ann Arbor, Michigan. pp: 333-364.

1997 Kapila, S.*: The Biology of Temporomandibular Joint Degeneration: The Role of Matrix Degrading Enzymes. In: Science and Practice of Occlusion. Ed: McNeill C. Quintessence Publishing Co, Inc. pp:235-258.

2000 Kapila, S.*, and Chen, J.J.: Matrix metalloproteinases in orthodontic tooth movement: principles and potential applications. In: Biological Mechanisms of Tooth Movement and Craniofacial Adaptation. Eds: Davidovitch, Z and Mah, J. Harvard Society for the Advancement of Orthodontics, Boston, MA. pp: 107- 118.

2000 van Dijke, C.F., Peterfy, C.J., Kirk, B.A., Kapila, S., Genant, H.K.: MR imaging of the normal and arthritic rabbit temporomandibular joint. van Dijke, C.F., Ph.D. Dissertation, drukkerij Groenenvelt bv Landgraaf, The Netherlands. pp:99-113.

2003 Kapila, S*., Sachdeva, R.C.L., Hannam, A.G., Farman, A.G.: Discussion and recommendations of breakout sessions. In: Proceedings of Inaugural Coast Conference: Craniofacial Imaging in the 21st Century. Eds: Kapila, S. and Farman, A.G. Blackwell Munskgard, Copenhagen, Denmark. Pp:179-182.

2005 Huang, J., King, G., and Kapila, S.*: Biologic Mechanisms of Tooth Movement. In: Esthetic Strategies in Orthodontics. Ed: Nanda, R. Elsevier/Saunders, St. Louis, Missouri. Pp:17-37.

2009 Haerian, A., Kapila., S.* Biomechanics in Orthodontics. In: Mosby’s Orthodontic Review. Ed: English, J. Mosby Publishing. Pp: 96-103.

2009 Kapila S.* Current and Future Innovations in Diagnostics and Therapeutics of TMJ Diseases. In: Temporomandibular Disorders and Orofacial Pain. Craniofacial Growth Series, Monograph Number 43. Eds: McNamara, J.A. and Kapila, S. Center for Human Growth and Development, University of Michigan, Ann Arbor, Michigan. Pp: 283-310.

2009 Kapila, S.* and Conley, RS.: Optimizing Biomechanics in Complex and Compromised Cases. In: Current Therapy in Orthodontics. Nanda R., Kapila, S. Mosby Elsevier. Pp: 228-250.

2012 Cevidanes, L., Kapila, S., Kharbanda OP. 3D Imaging in Orthodontics. In. Kharbanda OP (Ed).

2014 Kapila, S.,* King, G. Biologic Mechanisms in Orthodontic Tooth Movement. In: Esthetic Strategies in Orthodontics (2nd Edition). Ed: Nanda, R. Elsevier/Saunders, St. Louis, Missouri.

2014 Haerian, A., Kapila., S.* Biomechanics in Orthodontics. In: Mosby’s Orthodontic Review (2nd Edition). Ed: English, J. Mosby Publishing.

2014 Kapila, S. Contemporary Concepts on Cone-Beam Computed Tomography in Orthodontics. In: Cone Beam Computed Tomography in Orthodontics: Indications, Insights and Innovations. Ed: Kapila, S. Wiley Blackwell, Ames, Iowa.

2014 Kharbanda OP, Wadhawan, N., Balachandran, R., Kandasamy D., Kapila, S.D.: Functional and Technical Characteristics of Different Cone-Beam Computed Tomography Units. In: Cone Beam Computed Tomography in Orthodontics: Indications, Insights and Innovations. Ed: Kapila, S. Wiley Blackwell, Ames, Iowa.

2014 Hajati, A-K., Cevidanes L.H.S., Iwasaki, L., Nickel J., Kapila, S.D.: Application of 3D TMJ Imaging to TMJDs, TMJ Functional Analyses and Orthodontic Treatment Outcomes. In: Cone Beam Computed Tomography in Orthodontics: Indications, Insights and Innovations. Ed: Kapila, S. Wiley Blackwell, Ames, Iowa.

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2014 Kapila, S.D., Nervina, J.M.: Alveolar Boundary Conditions in Orthodontic Diagnosis and Treatment Planning. In: Cone Beam Computed Tomography in Orthodontics: Indications, Insights and Innovations. Ed: Kapila, S. Wiley Blackwell, Ames, Iowa.

2014 Nervina, J.M., Kapila, S.D.: Assessment of Root Position and Morphology by Cone-Beam Computed Tomography. In: Cone Beam Computed Tomography in Orthodontics: Indications, Insights and Innovations. Ed: Kapila, S. Wiley Blackwell, Ames, Iowa.

2014 Kapila, S.D., Nervina, J.M.: 3D Image-Aided Diagnosis and Treatment of Impacted and Transposed Teeth. In: Cone Beam Computed Tomography in Orthodontics: Indications, Insights and Innovations. Ed: Kapila, S. Wiley Blackwell, Ames, Iowa.

2014 Nervina, J.M., Kapila, S.D., Mir, C.F.: Assessment of Maxillary Transverse Deficiency and Treatment Outcomes by Cone-Beam Computed Tomography . In: Cone Beam Computed Tomography in Orthodontics: Indications, Insights and Innovations. Ed: Kapila, S. Wiley Blackwell, Ames, Iowa.

2016 Lee JD, Becker JI, Larkin LM, Kapila SD. Fabrication and Morphological Characterization of a Three dimensional, Multi-phasic, Scaffoldless, Tissue-engineered Temporomandibular Joint Disc-Ligament Complex Construct. In: Kapila SD, Goonewardene M, eds. Interdisciplinary Therapy: Using Contemporary Approaches for Complex Cases. Monograph 52, Craniofacial Growth Series, The University of Michigan, Ann Arbor, 291-315.

ORIGINAL ARTICLES TRANSLATED INTO DIFFERENT LANGUAGES

1990 Kapila, S.*, Sakima, T., Miyazaki, S., and Sachdeva, R.: Ligas ortodontica correntmente em uso. Revisao (Parte I). Revista de Odontologia da Universidade de Sao Paulo, 4:334-342.

1990 Sachdeva, R., Miyazaki, S., Sakima, T., and Kapila, S.: Fios Correntmente em uso em ortodontia. Revisao (Parte II). Revista de Odontologia da Univesidade de Sao Paulo, 4:343-348.

1994 Kapila, S.*, and Quo, S.D.: Kieferorthopädische drahte - Eigenschagten und optimale anwendungsmöglichkeiten. Informationen aus Orthodontie und Kieferorthopedie. 1994(3):373-89.

1995 Kapila, S.*, and Quo, S.D.: Alambres de ortodontica: propiedades y aplicaciones clínicas óptimas. Revisita Espanola De Ortodoncia, 25:285-300.

(* = principal and corresponding author)

OTHER PUBLICATIONS

1985 Kapila, S.: Comparative cephalometrics - Review of literature. Nairobi University Journal of Dentistry, Sept 1985; 27-31.

1992 Kapila, S.: Friction in orthodontics. Pacific Coast Society of Orthodontists Bulletin, 64:39-41.

1998 Kapila, S., Carlson, C., Van den Berg, H.R. Orthodontic treatment of anterior cross-bite and dental asymmetry associated with an impacted canine. Case Studies in Orthodontics, II (2):1-11.

ABSTRACTS

1984 Bowry, T., Likimani, S., Kapila, S. and Omari, M.: Hepatitis B viral serology in dental and paradental staff in Kenya. Proceedings of the Hepatitis B Virus in East Africa Seminar, Nairobi MSD International, pp: 25- 26.

1989 Kapila, S., Angolkar, P., Duncanson, M.G. Jr., and Nanda, R.S.: Effect of wire size and alloy on bracket- wire friction. Journal of Dental Research, 68 (SI):1636A.

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1989 Curtis, D., Miller, A., Nielsen, I., and Kapila, S.: Lateral shifts in occlusion of the Macaca mullata monkey. Journal of Dental Research, 68 (SI): 1866A.

1990 Kapila, S., Miller, A.J., Curtis, D., and Hatcher, D.: Effect of lateral deviation of mandibular position on craniomandibular growth. Journal of Dental Research, 69 (SI):339A.

1990 Curtis, D.A., Miller, A.J., and Kapila, S.: Bone density and vertical dimension changes in the rhesus monkey. Journal of Dental Research, 69 (SI):305A.

1990 Kapila, S., and Sachdeva, R.: Mechanical properties and clinical applications of orthodontic wires. Yearbook of Dentistry, 90-93.

1991 Curtis, DA., Kapila, S., Nielsen, I.L., Miller, A.J.: Dento-alveolar adaptations to vertical dimensions in adult rhesus monkeys. Journal of Dental Research, 70 (SI).

1992 Quo, S.D., Haugen, J.W., Watanabe, L., and Kapila, S.: Evaluation of nickel-titanium wire properties following clinical use. Journal of Dental Research, 71 (SI):140A.

1992 Kapila, S., Lee, C., Tavakkoli-Jou, M., Kao, R., and Miller, A.J.: An animal model for juvenile rheumatoid arthritis of the temporomandibular joint. Journal of Dental Research, 71 (SI): 237A.

1992 Kapila, S., Lee, C., Miller A.J., and Richards, D.: Matrix-degradative activity in a juvenile animal model of antigen-induced arthritis. Journal of Dental Research, 71 (SI): 237A.

1992 Kapila, S., Lee, C., and Richards, D.: Specific metalloproteinases released by temporomandibular joint disc in culture. Journal of Dental Research, 71 (SI): 213A.

1992 Kapila, S., Lee, C., and Richards, D.: In vitro synthesis of metalloproteinases and their inhibitors by temporomandibular joint disc and disc cells. American College of Rheumatology Scientific Abstracts, S173:C-37.

1992 Haugen, J., Watanabe, L., and Kapila, S.: Load-deflection characteristics of nickel-titanium wires following clinical use and dry-heat sterilization. American Journal of Orthodontics and Dentofacial Orthopedics, 102:573.

1993 Kapila, S., Lee, C., Wong, S., and Richards, D.: Mechanisms of matrix degradation in the temporomandibular joint disc. Journal of Dental Research, 72(SI):301.

1994 Kapila, S., Lee, C., Miller, A.J., and Richards, D.W.: Histochemical changes in temporomandibular joint (TMJ) disc during experimental arthritis. Journal of Dental Research, 73 (SI):303.

1994 Sing, P.J., Duong, T., Richards, D.W., and Kapila, S.: Matrix metalloproteinases and inhibitor regulation by mandibular condyle articular cells. Journal of Dental Research, 73 (SI):266.

1994 Lyons, M.S., Richards, D.W., and Kapila, S.: Mechanically induced expression of TGF-b2 by periodontal ligament cells. Journal of Dental Research, 73 (SI):194.

1994 Vu, H.A.Q., Kapila, S., Curtis, D., Nielsen, I.L., and Miller, A.J.: Computer tomography analysis of the rabbit cranioskeleton. Journal of Dental Research, 73 (SI):220.

1994 Kapila, S., Lee, C., and Richards, D.W.: Temporomandibular joint (TMJ) disc matrix degradation in experimental arthritis. Journal of Bone and Mineral Research, 9:S313.

1995 Tavakkoli Jou, M.J., Miller, A.J., and Kapila, S.: Abnormal mandibulofacial development in experimental arthritis of the juvenile temporomandibular joint. American Journal of Orthodontics and Dentofacial Orthopedics., 107: pp 688.

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1995 Kapila, S., and Richards, D.W.: Matrix metalloproteinases and proteinase inhibitors in antigen-induced arthritis of the juvenile temporomandibular joint. American Journal of Orthodontics and Dentofacial Orthopedics. 107: pp 688.

1995 Kirk, B., van Dijke, C., Miller, A.J., and Kapila, S.: Development and characterization of an experimental model of arthritis of the temporomandibular joint. Journal of Dental Research, 74 (SI):1958A.

1995 Tavakkoli Jou, M.J., Miller, A.J., and Kapila, S.: Abnormal mandibulofacial development in experimental arthritis of the juvenile temporomandibular joint. Journal of Dental Research, 74 (SI):1960A.

1995 Demsar, F., Roberts T.P.L., Schwickert, H.C., van Dijke, C.F., Shames, D.M., Peterfy, C.G., Kapila, S.D., Brasch, R.C.: MR mapping of tissue permeability and blood volume based on contrast enhancement using a blood pool agent. Contrast Media Research, Finland, June, 1995.

1995 Demsar, F., Roberts, T.P.L., Schwickert, H.C., van Dijke, C.F., Shames, D.M., Mann, J., Kapila, S., Peterfy, C.G., Saeed, M., and Brasch, R.C.: A mapping technique of microvascular permeability (PS) and tissue blood volume (BV) using a blood pool MRI contrast agent. Third Scientific Meeting and Exhibition of the Society of Magnetic Resonance, Nice, France, August 1995:1017

1995 Peterfy, C.G., van Dijke, C.F., Kapila, S., Brasch, R., Mann, J.S., Lang, P., and Genant, H.K.: MRI quantification of abnormal synovial capillary permeability in the arthritic rabbit knee using a macromolecular contrast agent. European Congress of Radiology. Vienna, Austria, March, 1995:S13.

1996 Rao, Y., Shi, S.T., and Kapila, S.: Cyclic mechanical strain modulates the expression of matrix macromolecules and differentiation of chondrocytes. Journal of Dental Research, 75 (SI):119.

1996 Kirk, B.A., van Dijke, C., Peterfy, C., and Kapila, S.: Quantitative parameters of enhanced magnetic resonance imaging correlate with severity of TMJ arthritis. Journal of Dental Research, 75 (SI):122.

1996 Kapila, S., Villadelgado, M., Seunghyun, K., Liu, M., and Peikoff, E.: Relaxin and b-estradiol modulate the expression of matrix metalloproteinases in TMJ disc cells. Journal of Dental Research, 75 (SI):123.

1996 Rao, Y., Shi, S.T., and Kapila, S.: Differentiation-related modulation of matrix macromolecules in mechanically stimulated chondrocytes. Journal of Bone and Mineral Research. 11:S297

1997 Colliou, O., Mathews, T., Lotz, J., and Kapila, S.: Static mechanical loading modulates collagenase expression in the rabbit annulus fibrosus. Journal of Orthopedic Research Society.

1997 Kapila, S., and Shiga, M.: Differential modulation of TGF-bs and matrix metalloproteinase expression in mechanically stimulated osteoblasts. Journal of Dental Research. 76 (SI):377

1998 Hu, B., and Kapila, S.: TGF-b1 inhibits relaxin-induced expression of collagenase and stromelysin in temporomandibular joint fibrocartilaginous cells. Journal of Dental Research. 77 (SI):188

1998 Kapila, S., and Yiqiang, X.: The induction of collagenase by relaxin in fibrocartilaginous cells is mediated by the AP-1 and PEA3 promoter sites. Journal of Dental Research. 77 (SI):634

1998 Trang, D., Hu, B., Parker, M., and Kapila, S.: Relaxin and b-estradiol induce collagenase expression in temporomandibular disc explants. Journal of Dental Research. 77 (SI):635

1998 Shiga, M., Kapila, Y., and Kapila, S.: Ascorbic acid enhances collagenase expression in human periodontal ligament cells. Journal of Dental Research. 77 (SI):1012

1999 Hu B., Kapila, Y.L., Shiga, M., and Kapila, S.: Fibronectin and its fragments modulate matrix metalloproteinase and inhibitor expression in TMJ disc cells. Journal of Dental Research, 78:439.

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2000 Duong, T., Shiga, M., and Kapila, S.: Modulation by relaxin of proteinases and glycosaminoglycans in the temporomandibular joint (TMJ) disc. Journal of Dental Research, 79 (SI):146

2001 Naqvi, T., Zhang, Q., Duong, T., and Kapila, S.: Relaxin’s induction of collagenase directly mediates loss of collagen in rabbit TMJ disc explants. Journal of Dental Research, 80 (SI).

2002 Buddhikot, M. and Kapila, S.: Regulation of matrix metalloproteinases by relaxin in breast cancer cells. J Cancer Res.

2002 Zhang, Q., Buddhikot, M., and Kapila, S.: Dexamethasone mediates osteoblastic differentiation of human PDL cells by inhibiting collagenase expression. Journal of Dental Research, 81A (SI): 467. iadr.confex.com/iadr/2002SanDiego/techprogram/abstract_19789.htm

2004 Hashem, G., Zhang, Q., Hayami, T., Kapila, S.: Female hormones modulate matrix loss in TMJ and symphyseal fibrocartilages. Journal of Dental Research. 83 (SI): 0224. iadr.confex.com/iadr/2004Hawaii/techprogram/abstract_45775.htm

2004 Hashem, G., P. Rim, P., Lotz, J., Kapila, S.: Bioengineering cartilage using rat mesenchymal cells in 3-D gels. Journal of Dental Research. 83 (SI): 3894. iadr.confex.com/iadr/2004Hawaii/techprogram/abstract_47092.htm

2004 Hayami, T., Q. Zhang, Q., Kapila, S.: Endogenous collagenase regulates osteoblastic differentiation of periodontal ligament (PDL) cells. Journal of Dental Research. 83 (SI): 2596. iadr.confex.com/iadr/2004Hawaii/techprogram/abstract_47360.htm

2006 Hayami, T, Kapila, YL., Kapila, S.: Osteoblastic differentiation of PDL cells is regulated by collagenase-1. Journal of Dental Research. 85A (SI):1665. iadr.confex.com/iadr/2006Orld/techprogram/abstract_74517.htm

2006 Uston, K., Hayami, T., Chen, C., Xu, W., Kapila, S.: Targeted modulation of collagenases by female hormones in mouse fibrochondrocytes. Journal of Dental Research. 85A (SI): 0022. iadr.confex.com/iadr/2006Orld/techprogram/abstract_76254.htm

2006 Wang, W., Hayami, T., Chen, C., Kapila, S.: Relaxin and estrogen receptors in mouse TMJ and meniscus fibrocartilages. Journal of Dental Research. 85A (SI) 0021. iadr.confex.com/iadr/2006Orld/techprogram/abstract_75282.htm

2006 Xu, J., Wang, W., Hayami, T., Staples, A., Lotz, J., Kapila, S.: Chondrogenic differentiation of HMSCs in 3D alginate gels. Journal of Dental Research. 85A (SI) 0763. iadr.confex.com/iadr/2006Orld/techprogram/abstract_75827.htm

2006 Hayami, T., Kapila, Y., Kapila, S.: Osteoblastic differentiation of periodontal ligament cells is regulated by Collagenase-1. Journal of Dental Research. 85A (SI) 1665. iadr.confex.com/iadr/2006Orld/techprogram/abstract_74517.htm

2006 Hayami, T., Kapila, Y., Kapila, S.: Collagenase-1 and -3 differentially upregulate markers of osteoblastic differentiation. American Society for Cell Biology.

2007 Xu, J., Cheng, K., Wang, W., Ludeman, M., Lotz, J., Kapila, S.: Comparison of hMSCs chondrogenesis in sodium and protanal alginate gels. Journal of Dental Research, 86A (SI): 1938. iadr.confex.com/iadr/2007orleans/techprogram/abstract_92269.htm

2007 Dunn MD., Park CH., P. Kostenuik, P., Kapila, S., Giannobille, W.: Local delivery of osteoprotegerin for orthodontic anchorage. Journal of Dental Research, 86A (SI): 1417. iadr.confex.com/iadr/2007orleans/techprogram/abstract_92978.htm

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2007 Wang, W., Hayami, T., Kapila, S.: Estrogen and relaxin induce while progesterone represses MMP expression in TMJ fibrochondrocytes. Journal of Dental Research, 86A (SI): 1279. iadr.confex.com/iadr/2007orleans/techprogram/abstract_92759.htm

2008 Joseph, J., Kapila, Y.L., Hayami, T., Kapila, S.: Disease-associated extracellular matrix suppresses osteoblastic differentiation of human periodontal ligament cells by MMP-1. Journal of Dental Research, 87A (SI): 1259.

2008 Hayami, T., Kapila, Y.L., Kapila S.: Collagenase-1 and -3 differentially regulate MG63 cell osteoblastic differentiation. Journal of Dental Research. 87B (SI): 0023.

2008 Xu, J., Wang, W., Kapila, Y., Lotz, J., Kapila S.: Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells. Journal of Dental Research, 87B (SI).

2008 Wang, W., Kapila, S.: ER-α enhances and ER-β represses estrogen-induced MMPs in TMJ fibrochondrocytes. Journal of Dental Research, 87B (SI).

2009 Joseph, J., Kapila, YL., Hayami, T., Kapila, S. Disease-associated ECM fragment modulates differentiation and activity of osteoclastic cells. Journal of Dental Research, 88A (SI).

2009 Hayami, T., Kapila, YL., Kapila, S. MMP-13’s Regulation of osteoblastic differentiation occurs via low- Density Lipoprotein Receptor-Related-Protein. Journal of Dental Research, 88A (SI)

2009 Xu, J., Hayami, T., Kapila, YL., Kapila, S. MMP-1 modulates osteoblastic differentiation of human PDL mesenchymal progenitor cells. Journal of Dental Research, 88A (SI)

2009 Nair R, Ahmad N, Wang W, Kapila S. Relaxin receptor RXFP1 (LGR7) is the primary mediator of relaxin induced matrix metalloproteinases in mouse TMJ fibrochondrocytes. Hinman Symposium, Cincinnati, Ohio, 2009.

2010 Hayami, T., Kapila, YL., Kapila, S. MMP-1 regulates osteoblastic differentiation via Protease-Activated Receptor-1. Journal of Dental Research, 89B (SI)

2010 Paula-Silva, FWG., Ghosh, A., Higinio Arzate, H., Kapila, S., da Silva, LAB., Kapila., Y. CEMP-1 and ERK mediate periodontal ligament cell differentiation and cementogenesis. Journal of Dental Research, 89B (SI)

2010 Nair R, Ahmad N, Wang W, Kapila S. Relaxin receptor RXFP1 (LGR7) is the primary mediator of relaxin induced matrix metalloproteinases in mouse TMJ fibrochondrocytes. Journal of Dental Research, 89B (SI) (winner of the IADR Travel Award).

2011 Park Y, Hosomichi J, Kapila S. Immortalization and characterization of mouse temporomandiblar disc cell clones. 24th Annual Meeting of Japanese Society for TMJ and 2nd Asian Congress for TMJ, Hiroshima, Japan.

2012 Park Y, Okagbare P, Ahmad N, Hayami T, Morris M, Kapila S. Relaxin and estrogen modulate targeted matrix loss in TMJ disc. Journal of Dental Research, 91A (SI)

2012 Hosomichi J, Park Y, Kapila S. Immortalization and characterization of mouse temporomandibular joint disc cells. Journal of Dental Research, 91B (SI)

2014 Lee, J.D., Becker, J.I., Kapila, S.D., Larkin, L.M. Morphological characteristics of a three-dimensional multi-phasic tissue engineered temporomandibular joint construct. Presented at the Seventh Scientific Meeting of the TMJ Association: Genetic and Epigenetic Basis of Temporomandibular Joint Disorders and related Chronic Overlapping Conditions, Bethesda, Maryland, September 7-9, 2014. 2014 Lee, J.D., Becker, J.I., Kapila, S.D., Larkin, L.M. Morphology and histology of the temporomandibular joint: Pig versus sheep model for tissue engineering applications. Presented at the Seventh Scientific 43 44

Meeting of the TMJ Association: Genetic and Epigenetic Basis of Temporomandibular Joint Disorders and related Chronic Overlapping Conditions, Bethesda, Maryland, September 7-9, 2014. 2014 Lee, J.D., Becker, J.I., Kapila, S.D., Larkin, L.M. Morphological characteristics of a three-dimensional multi-phasic tissue engineered temporomandibular joint construct. Presented at TERMIS Americas: Tissue Engineering and Regenerative Medicine International Society, Washington D.C., December 13-16, 2014.

2015 Ge, C., Sun, H., Li, Y., Kapila, S., Franceschi, RT. Runx2 and Runx2 phosphorylation are required for in vitro TMJ chondrocyte differentiation and OA-associated gene expression. Journal of Dental Research, 94A (SI): 2011.

2015 Kapila, S., Park, Y., Ahmad, N., Hosomichi, J., Hayami, T., Xu, P.: Mechanisms for relaxin’s modulation of fibrocartilage MMPs and matrix loss. Journal of Dental Research, 94A (SI): 1840.

2015 Crouch, SB., Dzingle, J., Tyus, J., Kapila, S., Eber, RM., Gonzalez-Cabezas, C., Ndege, P., Kapila, YL.: Oral health status of adults in rural Meru, Kenya. Journal of Dental Research, 94A (SI): 4143.

2015 Ge, C., Li, Y., Sun H., Kapila, S., Franceschi, R.T.: Discoidin receptor 2 is necessary for in vitro TMJ chondrocyte differentiation while its absence is associated with aging related TMJ degeneration. American Society for Bone and Mineral Research Annual Meeting. Journal of Bone and Mineral Research, 30:S77

2016 Park, Y., Jinping Xu, JP., Kapila, S. Estrogen and relaxin mediate targeted increase in TMJ subchondral bone porosity that requires MMP9 and MMP13. Journal of Dental Research, 95B (SI)

2017 Ge C, Mohamed F, Binrayes A, Kapila S and Franceschi RT. An Important Role for Discoidin Receptor 2 in TMJ Development and Aging. Journal of Dental Research, 96A (SI).

2017 Smith, S., Schneider, D., Hayami, T., Hatch, N., Kapila, S.: RANKL enhances orthodontic tooth movement and root resorption in rats. Journal of Dental Research, 96A (SI).

AUDIOTAPES AND VIDEO RECORDINGS

2003 Kapila, S.: Efficient Treatment Through Selective Mechanics. American Association of Orthodontists Audio Library, St. Louis, Missouri. (audiotape)

2004 Kapila, S.: Understanding TMJ Disorders: Future Innovations in Diagnosis and Treatments. American Association of Orthodontists Audio Library, St. Louis, Missouri. (audiotape)

2005 Kapila, S.: The Materials / Mechanics Interface in Optimizing Treatment Results. American Association of Orthodontists Audio Library, St. Louis, Missouri. (DVD)

2008 Kapila, S.: Optimizing Treatment Mechanics in Complex and Compromised Cases. American Association of Orthodontists Audio Library, St. Louis, Missouri. (DVD)

2010 Kapila, S.: Pathways to Success in Academic Orthodontics. American Association of Orthodontists Audio Library, St. Louis, Missouri. (DVD)

2010 Kapila, S.: TMJ Disorders: Innovations in Diagnostics and Therapeutics. American Association of Orthodontists Audio Library, St. Louis, Missouri. (DVD)

2011 Kapila, S.: Planning and Implementing Optimal Biomechanics in 3D: Applications to Impacted and Transposed Teeth. American Association of Orthodontists Audio Library, St. Louis, Missouri. (DVD)

2012 Kapila, S.: 3D Image-aided Treatment of Impacted and Transposed Teeth. American Association of Orthodontists Audio Library, St. Louis, Missouri. (DVD)

2013 Kapila, S.: Biomedicine- and Technology-driven Paradigm Shifts in Orthodontics. American Association of Orthodontists Audio Library, St. Louis, Missouri. (DVD) 44 45

2013 Kapila, S.: 3D Image-aided Treatment of Impacted and Transposed Teeth. American Association of Orthodontists Audio Library, St. Louis, Missouri. (DVD)

2014 Kapila, S.: Current Status of CBCT Imaging in Orthodontics. T.R.A.C.E. Video Inc., in Cone Beam Computed Tomography in Orthodontics: Indications, Insights and Innovations. Wiley Blackwell, Ames, Iowa. (DVD)

2015 Kapila, S.: New Horizons in Expedited Orthodontics: The Future Promise of Biomedicine and Technology. American Association of Orthodontists Audio Library, St. Louis, Missouri. (DVD)

2017 Kapila, S.: Integrating Technology and Biomedicine Towards Precision Orthodontics. American Association of Orthodontists Audio Library, St. Louis, Missouri. (DVD)

2018 Kapila, S.: Emerging Applications of CBCT in Orthodontic Diagnosis and Treatment Planning. American Association of Orthodontists Audio Library, St. Louis, Missouri. (DVD)

SOLICITED COMMENTARIES FOLLOWING REVIEW OF ARTICLES

1991 Kapila, S.: On the design of looped orthodontic retainer wires. Authors: Nikolai, R.J., Horner, K.D., Blackwell, D.A., Carr, R.J. Angle Orthodontist, 61:221.

1992 Kapila, S.: Facial growth during adolescence in early, average and late maturers. Authors: Silveira, A.M., Fishman, L.S., Subtelny, J.D., Kassebaum, D.K. Angle Orthodontist, 62:190.

1993 Kapila, S.: On tooth movement. Authors: Issacson, R.J., Lindauer, S.J., Davidovitch, M. Angle Orthodontist, 63:309.

1994 Boyd, R., and Kapila, S.: Fluoride releasing elastomeric chain. Angle Orthodontist, 64:210.

1994 Kapila, S.: Force application and decay characteristics of untreated and treated polyurethane elastomeric chains. Authors: Stevenson, J.S., Kusy, R.P. Angle Orthodontist, 64:465-6.

1997 Kapila, S.: Presence of denatured hemoglobin deposits in diseased temporomandibular joints. Authors: Zardeneta G., Milam, S.B., Schmitz, J.P. Journal of Oral and Maxillofacial Surgery, 55:1249.

1998 Kapila, S.: Effect of intrarticular versus systemic antiinflammatory drugs in a rabbit model of TMJ inflammation. Authors: Swift, J.Q., Roszkowski, M.T., Alton, T., Hargreaves, K.M. Journal of Oral and Maxillofacial Surgery, 56:1295.

1999 Kapila, S.: Determination of interleukin-1 receptor antagonist, interleukin-10, and transforming growth factor-b1 in synovial fluid aspirates of patients with temporomandibular disorders. Authors: Fang, P-K., Ma, X-C., Ma, D-L., Fu, K-Y. Journal of Oral and Maxillofacial Surgery, 57:928-929.

OTHER CREATIVE ACTIVITIES

Interinstitutional Collaborations: In 2001, I lead a group of orthodontic department chairs to launch the Consortium for Orthodontic Advances in Science and Technology (COAST) with the objective of transitioning discoveries in technology and biomedicine to clinical practice. This included holding biennial conferences with participants from industry, private practitioners, research and clinical academics. The biennial conferences that were initially funded by NIH and are now in the 18th year have had several successes in translating clinical applications, initiation of interinstitutional collaborations and faculty mentorship programs. These symposia and workshops have resulted in the publication of seven volumes of proceedings in Orthodontics and Craniofacial Research. Similarly, in 2008 I launched an interinstitutional grassroots faculty networking, mentorship and development group called Orthodontic Network of Educators (ONEders).

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ACADEMIC LEADERSHIP

1999-2004: Chair, Division of Orthodontics, Department of Growth and Development, UCSF. During this time, we implemented a comprehensive didactic curriculum, structured clinics to improve clinical care, student education and productivity and undertook fund raising to renovate the graduate orthodontics clinic.

2004-2015: Chair, Department of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry. In partnership with department faculty, division / program leadership and administrative staff, my academic, administrative and financial leadership achievements included: • Developing a vision and strategic plan in partnership with faculty that included enhancing clinical and didactic education, quality and quantity of research output, increased extramural funding, operational efficiencies and fiscal strength. • Successfully transitioning a primarily clinical department to a well-balanced academic/research unit while maintaining core strengths in clinical dentistry and keeping the clinical faculty engaged. This involved recruiting and mentoring several new tenure track faculty resulting in a broad mix of faculty, scholarship and gender and ethnic diversity. This transition resulted in an evolution of the Department from not having a single NIH-funded PI to all but one NIH-funded tenure track faculty during my tenure. • Implementing efficient operations and profitable clinics and reinvestment of surpluses towards the goals of the unit and school from departmental resources. These reinvestments included upgrading laboratory and clinic facilities, implementing the first electronic patient records at UM’s School of Dentistry, implementing a sustainable faculty incentive model, funding faculty start-up and bridging funds, enhancing educational and research experiences for students, implementing student stipends, and initiating new programs, while concurrently increasing the departmental reserves by five-fold. • Excellent successes in fund raising that resulted in establishment of two endowed professorships, and endowments for a new interprofessional CODA-accredited Craniofacial and Special Care Orthodontics (CFSCO) Fellowship program and two student scholarships. • Enhancing the faculty and student diversity in the Department through recruitment and development of female faculty and students of diverse backgrounds including first gens. • Hands-on research and career mentorship of faculty, postdoctoral fellows and graduate and dental students within UM and at other institutions, with success of several faculty in becoming NIH-funded investigators. • Supporting and developing graduate specialty students for careers in academic dentistry. • Achieving high level of faculty and student successes including awarding of numerous national and international research awards. • Initiating and sustaining novel inter-institutional initiatives for technology transfer; faculty development and mentorship in orthodontics; and interprofessional programs at University of Michigan including CFSCO Fellowship, and the Kenya Summer Research Program (KSRP). The KSRP is a unique interprofessional program that initially involved faculty and students from University of Michigan’s Schools of Medicine, Dentistry, Pharmacy, Nursing, Engineering, and Business to develop and implement sustainable resources for a rural community in Kenya. • Building interdepartmental and intercampus collaborations including establishing research collaborations with faculty at University of Michigan’s School of Engineering and recruiting diverse mentors from the Schools of Medicine, Dentistry and Public Health and the College of Literature, Science and Arts for an Institutional Career Development (K12) Award for training junior faculty and postdoctoral scholars in TMJD / Orofacial Pain (OP) with the goal of developing a strong cohort of diverse scholars in this field.

2016-present: Eugene E. West Endowed Chair, Division of Orthodontics, UCSF Working with faculty, residents and staff we have accomplished the following: • Defined a strategic direction and plan for the Division of Orthodontics focused on delivering outstanding patient-centered collaborative care founded on a strong didactic curriculum and scholarship, and strong alumni relations. • Revamped curriculum; streamlined courses to eliminate redundancies and increase diversity of content making the curriculum more comprehensive; initiated outcomes measures for clinics, residents and faculty including setting and review of annual objectives. • Optimized clinical operations and efficiencies through structuring regular and proactive faculty clinic coverage; resident and faculty leave policies and processes; decreased number of appliance prescriptions to a manageable level and clinic inventory controls; transitioned to central sterilization. The resulting improved clinical efficiencies have resulted in a net positive Division budget three of the first four years of my leadership after a decade of consistent deficits prior to my appointment as chair. 46 47

• Refined and implemented research requirements with the goal of generating higher caliber comprehensive projects that can be published and compete for national research awards. • Enhanced faculty, staff and resident communication and participation in Division activities through regular meetings. This includes a biannual full faculty retreats to engage faculty, staff and residents in decision making in defining curriculum content, organization and timing; clinical operations; build teamwork; and transition to a contemporary technology-based clinic. • Launched a campaign to create scholarship endowments for residents which has already realized over $1 million, the highest level of funds raised since our clinic renovation in 2000. Initiated the disbursement of the earnings on this endowment as travel and leadership scholarships to all residents in Fall 2018. Additional development activity has resulted in improved net position of the Orthodontics Fund for Excellence for use towards resident and division activities. • Recruited 7 new part-time volunteer faculty and two full-time faculty including a new graduate orthodontics program director. The recruitments have begun to improve the diversity in Division faculty, and the full-time faculty recruits are on their way towards becoming independent funded investigators. • Implemented a structured and transparent orthodontic admissions process. • Transitioning predoctoral curriculum towards a more cohesive program that will offer dental students additional and structured opportunities for orthodontic experiences. • Re-established strong alumni relationships as evidenced by record-breaking attendances at the annual alumni meetings and at receptions at national and regional meetings, and alumni giving to endowments and our annual fund. • Successfully completed 2019 CODA Accreditation review.

2016-2017: Special Advisor to the Dean on Strategic Initiatives • Working with the Dean of the School of Dentistry and other leaders, laid the groundwork for the launch of UCSF Dental Center. • Established an Advisory Board of internal and external board members and held regular meetings for planning the Dental Center. • Sought input from Dental Center stakeholders to gain insights on urgent priorities and formulated plans to address these once the Dental Center was launched. • Initial operationalization of some projects of the Dental School strategic plan pertaining to patient experiences and business. • Implemented a communications plan to keep stakeholders informed of the roll out of the Dental Centre- related enhancements. • Designed job descriptions and responsibilities of the Dental Center administrative team members.

2017-2019: CEO and Chief Dental Officer, UCSF Dental Center • Developed an operational structure, organizational chart and relationship of the Dental Center with the School of Dentistry. • Defined areas of responsibilities and hired or appointed an executive team including Director of Operations, Chief Financial Officer, Chief Business Officer and the Director of Marketing and Strategic Relations and formalized the reporting of the Director of Clinical Informatics and Technology to the CEO. Hired new Director of Clinical Informatics and Technology after the retirement of the previous director. • The Dental Center administrative team working in partnership with school-wide academic and staff leadership including clinical department chairs delivered on several Dental Center goals as outlined: o Developed the 2017-2022 Dental Center Strategic Plan based on the School of Dentistry’s 2015- 2020 strategic plan. o Developed relationships with relevant campus entities including Quality Improvement Executive Committee, Information Technology Committee, IT Field Services, Campus Procurement, Facilities Management, etc. o Introduced Lean Management principles to the Dental Center and lead this charge for the School of Dentistry. This included developing a Dental Center True North Scorecard (Key Performance Indicators – KPIs) and finalizing Key Behavior Indicators (KBIs) for all leadership. Other frontline tools (e.g. Active Daily Engagement, PDCA, etc.) were initiated. Developed standardization, capture and reporting of metrics (KPIs) to the True North Scorecard. o Completed several urgent projects (e.g. internal referrals, patient surveys, patient billing statement, central sterilization, standardized financial reporting, central image storage, staff training, facilities deep cleaning and upgrades, etc.). o Implemented several staff leadership and staff training programs and a monthly faculty study club to enhance collaborations and best practices. 47 48 o Initiated the next iteration of higher level long-term strategic projects including digital transformation of the Dental Center and new faculty practice models.

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