Dr Vincenzo Abbate
King's College London | Senior Lecturer in Analytical Toxicology
Biography
Dr Vincenzo Abbate completed his Pharm. D. in 2004 (110/110 cum laude) at Federico II
University of Naples (Italy). He then moved to the UK to undertake a PhD in Chemistry and
Analytical Sciences at The Open University. In 2008 he was awarded a prestigious
Maplethorpe Fellowship of the University of London for the promotion of teaching and research in the pharmaceutical area. Abbate is currently a Senior Lecturer in Analytical
Toxicology within the King’s Forensics Research Group at King’s College London (UK), where he leads a research group of 8 personnel and serves as the Programme Director for the Analytical Toxicology MSc programme. Abbate is a Titular Member of the IUPAC
Division of Chemistry and Human Health where he chairs an international committee on
New Psychoactive Substances and is the President of the IUPAC Subcommitte on
Toxicology and Risk Assessment. He is member of the RSC, ACS, SOT, BTS and TIAFT, a
Chartered Chemist (CChem) and Chartered Scientist (CSci) and is author/co-author of over
60 peer-reviewed publications.
Dr Vincenzo Abbate
King's College London | Senior Lecturer in Analytical Toxicology
CURRICULUM VITAE – Dr Vincenzo Abbate
NAME: Vincenzo Abbate
POSITION TITLE: Senior Lecturer Education & Training Completion DEGREE FIELD OF STUDY Date
INSTITUTION AND LOCATION Federico II University, Naples, Italy Pharm. D. 07/2004 Pharmacy
Federico II University, Naples, Italy EEA 11.2004 Pharmacy Qualified Pharmacist
The Open University, Milton Keynes, UK PhD 10/2008 Chemistry and Analytical Sciences King’s College London, London, UK PGCAPHE 07/2014 Higher Education Degree
Positions
2019-current Senior Lecturer in Analytical Toxicology, King’s Forensics, Department of Analytical, Environmental and Forensic Sciences, King’s College London, London, UK
2018-2019 Lecturer in Analytical Toxicology, King’s Forensics, Department of Analytical, Environmental and Forensic Sciences, King’s College London, London, UK
2017 Lecturer in Pharmaceutical Chemistry, Institute of Pharmaceutical Science, King’s College London, London, UK
2016 – 2017 Senior Research Scientist and Head of R&D, Drug Control Centre, King’s College London, London, UK
2010 – 2016 Research Associate, Institute of Pharmaceutical Science, King’s College London, London, UK
2015 Consultant – Legal Assistant, RPC Law Firm, London, UK
2008 – 2010 Maplethorpe Fellow of the University of London, Institute of Pharmaceutical Science, King’s College London, London, UK
Dr Vincenzo Abbate
King's College London | Senior Lecturer in Analytical Toxicology
2003 – 2004 Research Internship, Federico II University, Naples, Italy
2002 Pharmacy professional training, Naples, Italy Honours
Chair - IUPAC Subcommittee on Toxicology; Member of the Royal Society of Chemistry (MRSC); Chartered Chemist (CChem); Chartered Scientist (CSci); Fellow of the Higher Education Academy (FHEA); Titular Member, IUPAC Division of Chemistry and Human Health; Member of the IUPAC Subcommittees on Drug Discovery and Development (DDD); WAADS Affiliate Member. Member of the London Toxicology Group (LTG). Member of the British Toxicology Society (BTS). Member of the American Chemical Society (ACS). Member of the International Association of Forensic Toxicology (TIAFT). STEMNET Ambassador. Invited speaker (Keynote or Plenary) to refular national & international meetings.
Grant support
2008-2010 Maplethorpe Fellowship and Maplethorpe Travel awards (£90,000); 2013 BBSRC Sparking Impact Award (PI; £10,000); 2013 – 2017 Acquisition of a Waters Autopurification LC-MS system, two Agilent HP1100 HPLC systems, a Polymer Lab 1000 ELSD, and a Micromass ZQ MS from Pfizer (face value ~£200,000), two Thermo Finnigan Deca XP Ion Trap Mass Spectrometers and associated equipment (face value ~£100,000), and a Waters UPLC-Quattro Premier LC-MS/MS system (face value ~£100,000); 2013 IUPAC Young Observer Award (£2,000); 2014 IUPAC Project Award (PI; USD 7,000); 2015 Accretion Biotechnology Industrial Project Award (£29,200); 2016 MRC King’s Health Partner’s Research and Development Challenge Fund (PI; £78,692); 2017 Parkinson’s UK Project Grant (KCL Lead Applicant, £50,000); 2018 Theragnostics Limited – Industrial Grant (PI, £50,000); 2019 MRC King’s Health Partner’s Research and Development Challenge Fund (PI; £80,000); 2019 EPSRC King’s Together Grant (JPI; £75,000); 2020 NERC – research grant (co-I; £9,629.00); 2020 European Commission (PI; £176,735.00).
Dr Vincenzo Abbate
King's College London | Senior Lecturer in Analytical Toxicology
Publication list
Solid-Phase Synthesis and In-Silico Analysis of Iron-Binding Catecholato Chelators Gacesa, R., Tripodi, A., Cilibrizzi, A., Leggio, A., Hider, R. & Abbate, V., 12 Oct 2020, International Journal of Molecular Sciences. 21, 20, p. 1-14
The complexities associated with new psychoactive substances in influent wastewater: the case of 4-ethylmethcathinone Bade, R., Abbate, V., Abdelaziz, A., Nguyen, L., Trobbiani, S., Stockham, P., Elliot, S., White, J. M. & Gerber, C., 1 Oct 2020, Drug Testing & Analysis. 12, 10, p. 1494-1500
Pharmacokinetics of mephedrone and its metabolites in whole blood and plasma after a controlled intranasal administration to healthy human volunteers Czerwinska, J., Parkin, M., George, C., Kicman, A., Dargan, P. I. & Abbate, V., 23 Aug 2020, (Accepted/In press) Journal of Analytical Toxicology.
Comparative untargeted metabolomics analysis of the psychostimulants 3,4- methylenedioxy-methamphetamine (MDMA), amphetamine, and the novel psychoactive substance mephedrone after controlled drug administration to humans Steuer, A. E., Kaelin, D., Boxler, M. I., Eisenbeiss, L., Holze, F., Vizeli, P., Czerwinska, J., Dargan, P. I., Abbate, V., Liechti, M. E. & Kraemer, T., Aug 2020, Metabolites. 10, 8, p. 1-20
The First Reported Case of a Synthetic Cannabinoid Ethyl Ester Detected in a Postmortem Blood Toxicological Analysis Apirakkan, O., Hudson, S., Couchman, L., Cowan, D., Morley, S. & Abbate, V., 5 May 2020, Journal of Analytical Toxicology.
Isolation, detection and identification of synthetic cannabinoids in alternative formulations or dosage forms Apirakkan, O., Frinculescu, A., Denton, H., Shine, T., Cowan, D., Abbate, V. & Frascione, N., May 2020, Forensic Chemistry. 18.
In vitro phase I metabolic profiling of the synthetic cannabinoids AM-694, 5F-NNEI, FUB-APINACA, MFUBINAC and AMB-FUBINACA Apirakkan, O., Gavrilovic, I., Cowan, D. & Abbate, V., 17 Apr 2020, Chemical Research in Toxicology.
Detection of mephedrone and its metabolites in fingerprints from a controlled human administration study by liquid chromatography- tandem mass spectrometry and paper spray-mass spectrometry Czerwinska, J., Jang, M., Costa, C., Parkin, M., George, C., Kicman, A., Bailey, M., Dargan, P. I. & Abbate, V., 28 Feb 2020, Analyst (RSC).
Anti-doping: Two Scientists’ Points of View Cowan, D. A. & Abbate, V., 13 Feb 2020, Chemistry International.
Dr Vincenzo Abbate
King's College London | Senior Lecturer in Analytical Toxicology
Evidence of enzyme-mediated transesterification of synthetic cannabinoids with ethanol: potential toxicological impact Apirakkan, O., Gavrilovic, I., Floresta, G., Pierre, C., Cannaert, A., Stove, C., Dargan, P. I., Cowan, D. A., Couchman, L. & Abbate, V., 1 Jan 2020, Forensic Toxicology. 38, 1, p. 95- 107
Structure-based approach for the prediction of mu-opioid binding affnity of unclassified designer fentanyl-like molecules Floresta, G., Rescifina, A. & Abbate, V., 10 May 2019, International Journal of Molecular Sciences. 20, 9, 2311.
3D-QSAR assisted identification of FABP4 inhibitors: An effective scaffold hopping analysis/QSAR evaluation Floresta, G., Cilibrizzi, A., Abbate, V., Spampinato, A., Zagni, C. & Rescifina, A., 1 Mar 2019, BIOORGANIC CHEMISTRY. 84, p. 276-284
The role of mitochondrial labile iron in Friedreich's ataxia skin fibroblasts sensitivity to ultraviolet A Reelfs, O., Abbate, V., Cilibrizzi, A., Pook, M. A., Hider, R. C. & Pourzand, C., 1 Mar 2019, Metallomics. 11, 3, p. 656-665 iVS analysis to evaluate the impact of scaffold diversity in the binding to cellular targets relevant in cancer Cilibrizzi, A., Floresta, G., Abbate, V. & Giovannoni, M. P., 2019, JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. 34, 1, p. 44-50
FABP4 inhibitors 3D-QSAR model and isosteric replacement of BMS309403 datasets Floresta, G., Cilibrizzi, A., Abbate, V., Spampinato, A., Zagni, C. & Rescifina, A., 19 Dec 2018, Data in Brief.
Stability of mephedrone and five of its phase I metabolites in human whole blood Czerwinska, J., Parkin, M. C., Dargan, P. I., George, C., Kicman, A. T. & Abbate, V., 20 Oct 2018, Drug Testing And Analysis.
The ongoing challenge of novel psychoactive drugs of abuse. Part I. Synthetic cannabinoids (IUPAC Technical Report) Abbate, V., Schwenk, M., Presley, B. & Uchiyama, N., 28 Aug 2018, PURE AND APPLIED CHEMISTRY. 90, 8
On-water pyrrolidine-mediated domino synthesis of 2-iminoisatins Pelliccia, S., Abbate, V., Meneghetti, F., Frascione, N., Hider, R. C., Novellino, E., Tron, G. C. & Giustiniano, M., 25 Jul 2018, GREEN CHEMISTRY.
Hydroxypyridinone Journey into Metal Chelation Cilibrizzi, A., Abbate, V., Chen, Y-L., Ma, Y., Zhou, T. & Hider, R. C., 23 Jul 2018, Chemical Reviews.
Soft, adhesive (+) alpha tocopherol phosphate planar bilayers that control oral biofilm growth through a substantive antimicrobial effect Harper, R. A., Saleh, M. M., Carpenter, G., Abbate, V., Proctor, G., Harvey, R. D., Gambogi, R. J., Geonnotti, A., Hider, R. & Jones, S. A., 2 Feb 2018, Nanomedicine-Nanotechnology Biology And Medicine. Dr Vincenzo Abbate
King's College London | Senior Lecturer in Analytical Toxicology
The Effect of Banisteriopsis caapi (B. caapi) on the Motor Deficits in the MPTP-treated Common Marmoset Model of Parkinson's disease Fisher, R., Lincoln, L., Jackson, M. J., Abbate, V., Jenner, P., Hider, R. C., Lees, A. & Rose, S., 24 Jan 2018, PHYTOTHERAPY RESEARCH. 32, 4
Discovery of High-Affinity Cannabinoid Receptors Ligands through a 3D-QSAR Ushered by Scaffold-Hopping Analysis Floresta, G., Apirakkan, O., Rescifina, A. & Abbate, V., 2018, Molecules (Basel, Switzerland).
Proanthocyanidin trimer gallate modulates lipid deposition and fatty acid desaturation in Caenorhabditis elegans Nie, Y., Littleton, B., Kavanagh, T., Abbate, V., Bansal, S. S., Richards, D., Hylands, P. & Sturzenbaum, S. R., Nov 2017, Faseb Journal. 31, 11, p. 4891-4902
Iron in biology Abbate, V. & Hider, R. C., 31 Oct 2017, Metallomics. 9, p. 1467-1469
Fluorogenic substrates for the detection of saliva Gooch, J., Chua, C. R., Abbate, V. & Frascione, N., 29 Sep 2017, Forensic Science International: Genetics Supplement Series.
(68)Ga-THP-PSMA: a PET imaging agent for prostate cancer offering rapid, room temperature, one-step kit-based radiolabeling Young, J. D., Abbate, V., Imberti, C., Meszaros, L. K., Ma, M. T., Terry, S. Y. A., Hider, R. C., Mullen, G. E. & Blower, P. J., 1 Aug 2017, Journal of Nuclear Medicine. 58, 8, p. 1270- 1277
Analytical characterization of three cathinone derivatives, 4-MPD, 4 F-PHP and bk- EPDP, purchased as bulk powder from online vendors Apirakkan, O., Frinculescu, A., Shine, T., Parkin, M. C., Cilibrizzi, A., Frascione, N. & Abbate, V., 18 Jul 2017, Drug Testing And Analysis.
Novel Hyaluronic Acid Conjugates for Dual Nuclear Imaging and Therapy in CD44- Expressing Tumors in Mice In Vivo Dubey, R. D., Klippstein Martin, R. M., Wang, T-W., Hodgins, N. O., Mei, K-C., Sosabowski, J. K., Hider, R. C., Abbate, V., Gupta, P. N. & Al-Jamal, K., 1 Jan 2017, Nanotheranostics. 1, 1
Taggant materials in forensic science: A review Gooch, J., Daniel, B., Abbate, V. & Frascione, N., Oct 2016, TRENDS IN ANALYTICAL CHEMISTRY. 83, B, p. 49–54
A powerful mitochondria-targeted iron chelator affords high photoprotection against solar ultraviolet A radiation Reelfs, O. S., Abbate, V., Hider, R. C. & Pourzand, C., Aug 2016, Journal of Investigative Dermatology. 136, 8, p. 1692-1700
Monitoring Criminal Activity through Invisible Fluorescent “Peptide Coding” Taggants Gooch, J. P., Goh, H., Daniel, B. E., Abbate, V. & Frascione, N., 24 Mar 2016, Analytical Chemistry. Dr Vincenzo Abbate
King's College London | Senior Lecturer in Analytical Toxicology
Solid-phase synthesis of Rhodamine-110 fluorogenic substrates and their application in forensic analysis Gooch, J., Abbate, V., Daniel, B. & Frascione, N., 24 Mar 2016, Analyst. 141
Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth Li, J., Olaleye, E., Kong, X., Zhou, T., Ma, Y., Jurach, J., Al Rugaie, O., Hider, R. C., Zhang, G., Alsam, S. & Abbate, V., 22 Mar 2016, Polymer. 87, p. 64-72 5-Hydroxypyran-4-one derivatives as potential therapeutic iron–chelating agents Li, J., Abbate, V., Jurach, J., Kong, X. & Hider, R. C., 22 Jan 2016, ChemistrySelect. 1, 2, p. 297-300
Design, Synthesis and in Vivo Evaluation of Novel Glycosylated Sulfonylureas as Antihyperglycemic Agents Suaifan, G. A. R. Y., Shehadeh, M. B., Darwish, R. M., Al-Ijel, H. A. N. & Abbate, V., 6 Nov 2015, Molecules (Basel, Switzerland). 20, 11, p. 20063-20078
Establishing evidence of contact transfer in criminal investigation by a novel 'peptide coding' reagent Gooch, J., Koh, C., Daniel, B., Abbate, V. & Frascione, N., 1 Nov 2015, TALANTA. 144, p. 1065-1069.
Solvent-Free Click-Mechanochemistry for the Preparation of Cancer Cell Targeting Graphene Oxide Rubio Carrero, N., Mei, K-C., Klippstein Martin, R., Coutinho Da Costa, P. M., Hodgins, N., Wang, J. T-W., Festy, F., Abbate, V., Hider, R. C., Chan, K. L. A. & Al-Jamal, K. T., 17 Aug 2015, In : ACS Applied Materials and Interfaces. 7, 34, p. 18920–18923
Synthesis of double-clickable functionalised graphene oxide for biological applications Mei, K-C., Rubio, N., Coutinho Da Costa, P. M., Kafa, H., Abbate, V., Festy, F., Bansal, S. S., Hider, R. C. & Al-Jamal, K. T., 7 Aug 2015, Chemical communications (Cambridge, England). 51, 81, p. 14981-14984.
Design of novel fluorescent mitochondria-targeted peptides with iron-selective sensing activity Abbate, V., Reelfs, O. S., Hider, R. C. & Pourzand, C., 26 May 2015, Biochemical Journal. 469, 3, p. 357–366
Synthesis and Characterization of Novel Iron-Specific Bicyclic Fluorescent Probes Ma, Y., Kong, X., Abbate, V. & Hider, R. C., 21 Feb 2015, Sensors And Actuators B- Chemical. 213, p. 12-19
Deferitazole, a new orally active iron chelator Hider, R. C., Kong, X., Abbate, V., Harland, R., Conlon, K. & Luker, T., 17 Feb 2015, Dalton Transactions. 44, p. 5197-5204
Design and synthesis of novel pegylated iron chelators with decreased metabolic rate Li, J., Lu, Z., Kong, X., Ma, Y., Zhang, X., Bansal, S., Abbate, V. & Hider, R. C., 2015, Future Medicinal Chemistry. 7, 18, p. 2439-2449
Dr Vincenzo Abbate
King's College London | Senior Lecturer in Analytical Toxicology
Dual Selective Iron Chelating Probes with a Potential to Monitor Mitochondrial Labile Iron Pools Abbate, V., Reelfs, O. S., Kong, X., Pourzand, C. & Hider, R. C., 2015, CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY. 52, p. 784-787
Fluorogenic displacement biosensors for PSA detection using antibody- functionalised quantum dot nanoparticles Frascione, N., Gooch, J., Abbate, V. & Daniel, B., 2015, RSC Advances. 5, 9, p. 6595-6598 4 p. Novel mitochondria-targeted peptide iron chelators for iron sensing and protection against oxidative stress-induced mitochondrial damage
The Emerging Problem of Novel Psychoactive Substances Abbate, V., 2015, Chemistry International, 37, 1, p. 24-24.
Iron-sensitive fluorescent probes: monitoring intracellular iron pools Ma, Y., Abbate, V. & Hider, R. C., 15 Oct 2014, Metallomics. 7, p. 212-222
Anabolic steroids detected in bodybuilding dietary supplements – a significant risk to public health Abbate, V., Kicman, A. T., Evans-Brown, M., McVeigh, J., Cowan, D. A., Wilson, C., Coles, S. J. & Walker, C. J., 6 Oct 2014, Drug Testing & Analysis. 7, 7, p. 609-618
Polyethylene Glycol Conjugated Polymeric Nanocapsules for Targeted Delivery of Quercetin to Folate-Expressing Cancer Cells In Vitro and In Vivo El-Gogary, R., Wang, J., Rubio Carrero, N., Al-Jamal, W. A-J., Bourgognon, M., Kafa, H., Naeem, M., Klippstein Martin, R., Abbate, V., Leroux, F., Bals, S., Van Tendeloo, G., Kamal, AO., Awad, GAS., Mortada, N. & Al-Jamal, K., 25 Feb 2014, In : ACS Nano. 8, 2, p. 1384- 1401 18 p.
Manipulating the pH response of 2,3-diaminopropionic acid rich peptides to mediate highly effective gene silencing with low-toxicity Abbate, V., Liang, W., Patel, J., Lan, Y., Capriotti, L., Iacobucci, V., Bui, T., Chaudhuri, P., Kudsiova, L., Vermeer, L., Chan, P., Kong, X., Drake, A., Lam, J., Bansal, S. & Mason, J., 28 Dec 2013, JOURNAL OF CONTROLLED RELEASE. 172, 3, p. 929-938
Functional Characterization of Fluorescent Hepcidin Durrenberger, F., Abbate, V., Ma, Y., Arno, M. C., Jaiash, D., Parmar, A., Marshall, V., Latunde-Dada, G., Zimmerman, T., Senn, D., Altermatt, P., Manolova, V., Hider, R. & Bansal, S., 18 Sep 2013, Bioconjugate Chemistry. 24, 9, p. 1527–1532
Enzyme-Catalyzed Transetherification of Alkoxysilanes Abbate, V., Brandstadt, K. F., Taylor, P. G. & Bassindale, A. R., 2013, Catalysts. 3, 1, p. 27- 35
Conformational flexibility determines selectivity and antibacterial, antiplasmodial and anticancer potency of cationic α-helical peptides Vermeer, L., Lan, Y., Abbate, V., Ruh, E., Bui, T., Wilkinson, L., Kanno, T., Jumagulova, E., Kozlowska, J., Patel, J., McIntyre, C. A., Yam, WC., Siu, G., Atkinson, R. A., Lam, J., Bansal, S., Drake, A., Mitchell, G. H. & Mason, J., 5 Oct 2012, Journal of Biological Chemistry. 287, 41, p. 34120-34133
Dr Vincenzo Abbate
King's College London | Senior Lecturer in Analytical Toxicology
Photocrosslinked bovine serum albumin hydrogels with partial retention of esterase activity Abbate, V., Kong, X. & Bansal, S. S., 10 Feb 2012, ENZYME AND MICROBIAL TECHNOLOGY. 50, 2, p. 130 - 136
An artificial organosilicon receptor Abbate, V., Bassindale, A. R., Brandstadt, K. F. & Taylor, P. G., 2012, Polymer Chemistry. 3, 8, p. 2018-2027
Inclusion complexes between cyclic siloxanes and cyclodextrins: synthesis and characterization Abbate, V., Bassindale, A. R., Brandstadt, K. F. & Taylor, P. G., 2012, JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY. 74, 1, p. 223-230
A large scale enzyme screen in the search for new methods of silicon-oxygen bond formation Abbate, V., Bassindale, A. R., Brandstadt, K. F. & Taylor, P. G., 2011, Journal of Inorganic Biochemistry. 105, 2, p. 268–275
Biomimetic catalysis at silicon centre using molecularly imprinted polymers Abbate, V., Bassindale, A. R., Brandstadt, K. F. & Taylor, P. G., 2011, JOURNAL OF CATALYSIS. 284, 1, p. 68–76
Incorporation of 2,3-Diaminopropionic Acid into Linear Cationic Amphipathic Peptides Produces pH-Sensitive Vectors Lan, Y., Langlet-Bertin, B., Abbate, V., Vermeer, L. S., Kong, X., Sullivan, K. E., Leborgne, C., Scherman, D., Hider, R. C., Drake, A. F., Bansal, S. S., Kichler, A. & Mason, A. J., 14 Jun 2010, Chembiochem : a European journal of chemical biology. 11, 9, p. 1266 - 1272 7 p.
Quantitation of hepcidin in serum using ultra-high-pressure liquid chromatography and a linear ion trap mass spectrometer Bansal, S. S., Abbate, V., Bomford, A., Halket, J. M., Macdougall, I., Thein, S. L. & Hider, R. C., 15 May 2010, Rapid Communications in Mass Spectrometry. 24, 9, p. 1251 - 1259.
Preparation, Characterization, and Binding Profile of Molecularly Imprinted Hydrogels for the Peptide Hepcidin Abbate, V., Frascione, N. & Bansal, S. S., 15 Apr 2010, Journal of Polymer Science. Part A, Polymer Chemistry. 48, 8, p. 1721 - 1731
Enzyme mediated silicon–oxygen bond formation; the use of Rhizopus oryzae lipase, lysozyme and phytase under mild conditions Abbate, V., Bassindale, A. R., Brandstadt, K. F., Lawson, R. & Taylor, P. G., 2010, Dalton Transactions. 39, 48, p. 9361-9368
Simple and mild preparation of silica-enzyme composites from silicic acid solution Bassindale, A. R., Taylor, P. G., Abbate, V. & Brandstadt, K. F., 2009, JOURNAL OF MATERIALS CHEMISTRY. 19, p. 7606-7609