Opiates, Methadone, Alcohol, Barbiturates
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Best Bets from the Manchester Royal Infirmary Edited by K Mackway-Jones
247 BEST EVIDENCE TOPIC REPORTS Emerg Med J: first published as 10.1136/emj.19.3.248 on 1 May 2002. Downloaded from Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary Edited by K Mackway-Jones Clinical scenario Best evidence topic reports (BETs) summarise the evidence A 23 year old woman attends an emergency department hav- pertaining to particular clinical questions. They are not ing taken sixty 500 mg paracetamol tablets. Her four hour systematic reviews, but rather contain the best (highest paracetamol levels are above the treatment line. She does not level) evidence that can be practically obtained by busy want to be treated with intravenous therapy. You wonder practising clinicians. The search strategies used to find the whether oral antidote is as effective. best evidence are reported in detail in order to allow clinicians to update searches whenever necessary. The BETs published below were first reported at the Critical Three part question Appraisal Journal Club at the Manchester Royal Infirmary.1 In [patients who need an antidote for paracetamol overdose] Each BET has been constructed in the four stages that have is [intravenous therapy better than oral therapy] at [prevent- been described elsewhere.2 The BETs shown here together ing liver damage and death]? with those published previously and those currently under construction can be seen at http://www.bestbets.org.3 Six Search strategy BETs are included in this issue of the journal. Medline 1966 to 12/01 using the OVID interface. [exp acetyl- -
(12) Patent Application Publication (10) Pub. No.: US 2004/0024006 A1 Simon (43) Pub
US 2004.0024006A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2004/0024006 A1 Simon (43) Pub. Date: Feb. 5, 2004 (54) OPIOID PHARMACEUTICAL May 30, 1997, now abandoned, and which is a COMPOSITIONS continuation-in-part of application No. 08/643,775, filed on May 6, 1996, now abandoned. (76) Inventor: David Lew Simon, Mansfield Center, CT (US) Publication Classification Correspondence Address: (51) Int. Cl. ................................................ A61K 31/485 David L. Simon (52) U.S. Cl. .............................................................. 514/282 P.O. Box 618 100 Cemetery Road (57) ABSTRACT Mansfield Center, CT 06250 (US) The invention is directed in part to dosage forms comprising a combination of an analgesically effective amount of an (21) Appl. No.: 10/628,089 opioid agonist analgesic and a neutral receptor binding agent or a partial mu-opioid agonist, the neutral receptor binding (22) Filed: Jul. 25, 2003 agent or partial mu-opioid agonist being included in a ratio Related U.S. Application Data to the opioid agonist analgesic to provide a combination product which is analgesically effective when the combina (63) Continuation-in-part of application No. 10/306,657, tion is administered as prescribed, but which is leSS analge filed on Nov. 27, 2002, which is a continuation-in-part Sically effective or less rewarding when administered in of application No. 09/922,873, filed on Aug. 6, 2001, excess of prescription. Preferably, the combination product now Pat. No. 6,569,866, which is a continuation-in affects an opioid dependent individual differently from an part of application No. 09/152,834, filed on Sep. -
Capture and Immobilization of Exotic Small Ruminants
NAVC Conference 2009 ______________________________________________________________________________________________ CAPTURE AND IMMOBILIZATION OF EXOTIC blindfolded to reduce visual stimulation. If the head, SMALL RUMINANTS ears, antlers, or horns are manipulated then a halter can be applied and the head tied. Local anesthetic, sedation, Peregrine L. Wolff, DVM or immobilization agents can be administered within the Oregon Department of Fish and Wildlife chute. Corvallis, OR The design of the sorting and holding pens and runways leading to the chute should incorporate Nondomestic small ruminants can be encountered on principles developed for safely moving domestic cattle, exotic animal or cervid ranches on breeding farms, in sheep, and farmed deer. A circular pattern layout with, zoos or petting farms, and even as pets. Species non-slip solid footing, adequate lighting, and appropriate commonly kept outside of a zoological institution include: visual barriers are recommended for decreasing stress during the handling of any grazing species. Any Cervids: North American species such as elk (Cervus unnecessary noise should be minimized and lighting elaphus sp) white tail deer (Odocoileus virginianus) should be adequate but muted. Elevated catwalks and reindeer (Rangifer tarandus) or Eurasian species facilitate animal handling but should never go over the such as sika deer (Cervus nippon), fallow deer top of chute area as animals will become distracted by (Dama dama), axis deer (Axis axis), red deer (Cervus what is above them and reluctant and fearful to move elaphus), and muntjac (Muntiacus muntjak) forward. Animals should be restrained and handled Antelope: Scimitar-horned oryx (Oryx dammah), gently but firmly and it is important that they feel secure addax (Addax nasomaculatus), blackbuck (Antilope and balanced in the squeeze. -
The Cardiovascular Actions of Mu and Kappa Opioid Agonists In
THE CARDIOVASCULAR ACTIONS OF MU AND KAPPA OPIOID AGONISTS IN VIVO AND IN VITRO. By Abimbola T. Omoniyi, BSc (Hons) A thesis submitted in accordance with the requirements of the University of Surrey for the Degree of Doctor of Philosophy. Department of Pharmacology, September 1998. Cornell University Medical College, New York, NY 10021, ProQuest Number: 27733163 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a com plete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. uest ProQuest 27733163 Published by ProQuest LLC (2019). Copyright of the Dissertation is held by the Author. All rights reserved. This work is protected against unauthorized copying under Title 17, United States C ode Microform Edition © ProQuest LLC. ProQuest LLC. 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106 - 1346 ACKNOWLEDGEMENTS I would like to thank God through whom all things are made possible. Many thanks to Dr. Hazel Szeto for funding this thesis. Heartfelt gratitude to Dr. Dunli Wu for his support, encouragement and for keeping me sane. I thoroughly enjoyed the funny stories, the relentless Viagra jokes and endless tales of the Chinese revolution! Thanks to Dr. Yi Soong for all her support and generous assistance and all that food! Thanks to Dr. Ian Kitchen and Dr. Susanna Hourani for making this a successful collaborative degree. Thanks to my family for all their support and belief in me. -
Understanding Capture Myopathy—A Malignant Outcome of Stress During Capture and Translocation
Volume 7 • 2019 10.1093/conphys/coz027 Review article Themed Issue Article: Conservation of Southern Hemisphere Mammals in a Changing World Conserving wildlife in a changing world: Understanding capture myopathy—a malignant outcome of stress during capture and translocation Dorothy Breed 1,7, Leith C.R. Meyer2,5, Johan C.A. Steyl2,5, Amelia Goddard3,5, Richard Burroughs4,5,6 and Tertius A. Kohn1,2,* 1Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Boundary Road, Cape Town 7725, South Africa 2Department of Paraclinical Sciences, University of Pretoria, Soutpan Road, Onderstepoort 0110, South Africa 3Department of Companion Animal Clinical Studies, University of Pretoria, Soutpan Road, Onderstepoort 0110, South Africa 4Department of Production Animal Studies, University of Pretoria, Onderstepoort 0110, South Africa 5Centre for Veterinary Wildlife Studies, University of Pretoria, Soutpan Road, Onderstepoort, 0110, South Africa 6Mammal Research Institute, University of Pretoria, Soutpan Road, Onderstepoort 0110, South Africa 7Biodiversity Management Branch, Environmental Management Department, City of Cape Town, 53 Berkley Road, Maitland, 6504, South Africa *Corresponding author: Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Boundary Road, Cape Town 7725, South Africa. Tel.: +27 21 406 6235; Email: [email protected] ......................................................................................................................................................... -
Outline for Controlled Substances Program
Environmental Health and Safety Controlled Substances Program Date of Issuance: Review Date: 10/1/2019 (no changes) 10/01/2018 Revision Number: Initial Prepared by: EH&S Table of Contents HEADINGS Introduction Applicability Responsibilities Registration Requirements Authorized Use Ordering/Purchasing Administering and Dispensing Inventory Procedures (Continuing Records) Security Disposal FORMS: Registering or renewing a DEA or state license (CMU) Controlled Substances Authorized users list (CMU) Employee questionnaire for those with access to controlled substances (CMU) Record of Form 222 use (Order form) (CMU) Records of Controlled Substance Purchases (CMU) Record of Controlled Substance Administering and dispensing (CMU) Controlled Substance Physical Inventory (CMU) DEA Registration of Persons doing research or analysis (Form 225) DEA Registration of Dispensers (Form 224) DEA Registration Instructional (Form 224 and 226 to renew) DEA Report of loss or theft (Form 106) DEA Report of drugs surrendered (From 41) DEA SCHEDULES: Schedule I Schedule II Schedule III Schedule IV Schedule V INTRODUCTION State and Federal regulations have been promulgated concerning the use and handling of US Department of Justice Drug Enforcement Administration (DEA) controlled substances. These regulations are in place to address materials which are or have the potential to be addictive or habit forming. These substances have been categorized into “schedules” that have been created by the DEA to reflect their level of concern. The “Carnegie Mellon University DEA Controlled Substances Program” is intended to ensure that Carnegie Mellon University is in compliance with our regulatory requirements. Required activities under the DEA include: 1. Registration of your work with the DEA and with Carnegie Mellon’s Department of Environmental Health and Safety (EH&S). -
The Prevention and Treatment of Drug Misuse in Britain
If you have issues viewing or accessing this file contact us at NCJRS.gov. .. " FW The prevention and treatment of drug misuse in Britain "I Issued by Rererence Division BRITISH INFORMATION SERVICES All Agency of the British Government 845 THIRD AVENUE, NEW YORK, N.Y. ]0022 This material is prepared, edited, issued or circulated by British Information Servic(!s, 845 Third Avenue, New York, N. Y.l0022, which is registered under the Foreign Agents Registration Act as an agent of the Brilish Government. This material is filed with the Department of Justice where the required registration statement is available for public inspection. Registration does not indicate approval 0/ the contents of this material by the United States Government. PRINTED IN ENGLAND BY TRADE UNION LABOR BY COLUNS AND WILSON LTD., ANDOVER The prevention and treatment of drug misuse in Britain Prepared by REFERENCE DIVISION CENTRhL OFFICE OF INFORMATION, LONDON Oclo~'er 1978 Quote No RS94S/78 CLASSIFICATION 4(c) N.B.-This pamphlet is i//tellded to be used for referellce purposes alld may be freely used ill preparing articles, speeches, broadcasts, elc. No acknowledgment is necessary. Please Ilote the date ofpreparation. Tire text gives general gUidance only, and should 1I0t be treated as an authoritative statement of the law. Pamphlets ill this series may be obtained from the Tllformation Office at tlte British Embassy, Consulate or High Commission in tile inquirer's Co/lIltl'Y of residellce. CONTENTS Page INTRODUCTION 1 BACKGROUND .. 3 PREVENTING DRUG MISUSE 8 The Law 8 Health Education 17 TREATMENT AND REHABILITATION .. 20 Narcotic Drug Misuse and the Role of the Clinics 20 Treating Other Forms of Drug Misuse 26 Rehabilitation 26 INFORMATION AND RESEARCH ., 29 APPENDICES 1. -
Prescription of Controlled Drugs to Addicts
1876 BRITISH MEDICAL JOURNAL VOLUME 286 11 JUNE 1983 Br Med J (Clin Res Ed): first published as 10.1136/bmj.286.6381.1876 on 11 June 1983. Downloaded from For Debate . P Unacceptable face of private practice: prescription of controlled drugs to addicts THOMAS BEWLEY, A HAMID GHODSE Abstract practitioners. In the past three years, however, the pattern has shown a pronounced change (table), large numbers of addicts Self administered questionnaires completed by 69 out again having drugs prescribed for them by private general of 100 consecutive drug addicts two attending drug practitioners. These drugs are no longer heroin and cocaine dependence clinics that some suggested private general but other controlled drugs which are not included in the practitioners were easily persuaded to prescribe con- licensing regulations. trolled drugs. These drugs were usually methadone, dipipanone-cyclizine (Diconal), and methylphenidate (Ritalin). Numbers of new narcotic addicts notified to New narcotic addicts notified to Home Office the Home Office confirmed the practice, which may lead Source of notification to a severe spread of addiction, as occurred in the 1960s with heroin and cocaine. Year Hospital treatment Prison medical General medical Total centret officert practitionert If the General Medical Council or a tribunal set up 1972 480 250 80 800 in accordance with the Misuse of Drugs Act 1971 cannot 1973 430 230 150 807 stop then the 1974 380 240 250 870 the practice, present licensing system 1975 390 270 260 922 should be extended to include all controlled drugs. 1976 400 290 290 984 1977 450 290 370 1109 1978 590 240 520 1347 1979 610 270 720 1597 1980 570 240 790 1600 Introduction 1981* 760 320 1220 2300 Prescribing drugs of addiction to addicts is accepted medical Provisional. -
Table 6.12 Deaths from Poisoning, by Sex and Cause, Scotland, 2004
Table 6.12 Deaths from poisoning, by sex and cause, Scotland, 2004 ICD Cause of death Both Males Females ICD Cause of death Both Males Females Codes and substance sexes Codes and substance sexes ACCIDENTS INTENTIONAL SELF-HARM X40 Accidental poisoning by and exposure X60 Intentional self-poisoning by -49 to noxious substances 57 40 17 -69 and exposure to 166 92 74 X40 Nonopioid analgesics, antipyretics X60 Nonopioid analgesics, antipyretics and antirheumatics and antirheumatics Ibuprofen 1 1 - Meptazinol, Alcohol 1 1 - Paracetamol 1 - 1 Meptazinol, Dihydrocodeine, Amitriptyline, Tramadol, Alcohol 1 1 - Imipramine, Alcohol 1 1 - Paracetamol 15 6 9 X41 Antiepileptic, sedative-hypnotic, Paracetamol, Codeine, Alcohol 1 1 - antiparkinsonism and Paracetamol, Diazepam 1 - 1 psychotropic drugs, Paracetamol, Oxazepam 1 1 - not elsewhere classified Tramadol 3 - 3 Clozapine, Diazepam, Alcohol 1 - 1 X61 Antiepileptic, sedative-hypnotic, antiparkinsonism and X42 Narcotics and psychodysleptics psychotropic drugs, (hallucinogens), not elsewhere not elsewhere classified classified Amitriptyline 8 3 5 Cocaine, Amphetamine 1 - 1 Amitriptyline, Alcohol 1 1 - Codeine, Tylex, Paracetamol, Alcohol 1 - 1 Amitriptyline, Dihydrocodeine 1 - 1 Dihydrocodeine, Diazepam 1 - 1 Amitriptyline, Paracetamol 1 1 - Ecstasy 1 1 - Carbamazepine 2 - 2 Heroin 4 3 1 Carbamazepine, Paroxetine, Paracetamol 1 1 - Heroin, Cocaine 1 1 - Chlordiazepoxide, Co-proxamol 1 - 1 Heroin, Methadone, Alcohol 1 1 - Chlorpromazine, Alcohol 2 2 - Heroin, Morphine 1 1 - Citalopram, Alcohol 1 - -
Effects of Medication-Assisted Treatment (MAT) on Functional Outcomes Among Patients with Opioid Use Disorder (OUD)
NATIONAL DEFENSE RESEARCH INSTITUTE Effects of Medication- Assisted Treatment (MAT) for Opioid Use Disorder on Functional Outcomes A Systematic Review Margaret A. Maglione, Laura Raaen, Christine Chen, Gulrez Shah Azhar, Nima Shahidinia, Mimi Shen, Ervant J. Maksabedian Hernandez, Roberta M. Shanman, Susanne Hempel Prepared for the Office of the Secretary of Defense Approved for public release; distribution unlimited For more information on this publication, visit www.rand.org/t/RR2108 Published by the RAND Corporation, Santa Monica, Calif. © Copyright 2018 RAND Corporation R® is a registered trademark. Limited Print and Electronic Distribution Rights This document and trademark(s) contained herein are protected by law. This representation of RAND intellectual property is provided for noncommercial use only. Unauthorized posting of this publication online is prohibited. Permission is given to duplicate this document for personal use only, as long as it is unaltered and complete. Permission is required from RAND to reproduce, or reuse in another form, any of its research documents for commercial use. For information on reprint and linking permissions, please visit www.rand.org/pubs/permissions. The RAND Corporation is a research organization that develops solutions to public policy challenges to help make communities throughout the world safer and more secure, healthier and more prosperous. RAND is nonprofit, nonpartisan, and committed to the public interest. RAND’s publications do not necessarily reflect the opinions of its research clients and sponsors. Support RAND Make a tax-deductible charitable contribution at www.rand.org/giving/contribute www.rand.org Preface Over the past two decades, the U.S. Department of Defense (DoD) has invested unparalleled resources into developing effective treatments for military-related psychological health conditions. -
Guidelines for Prescribing Controlled Substances for Pain
GUIDELINES FOR PRESCRIBI NG CONTROLLED SUBSTANCE S FOR PAIN MEDICAL BOARD OF CALIFORNIA NOVEMBER 2014 Edmund G. Brown Jr., Governor David Serrano Sewell, J.D., President, Medical Board of California Kimberly Kirchmeyer, Executive Director, Medical Board of California Guidelines for Prescribing Controlled Substances for Pain Table of Contents PREAMBLE ..................................................................................................................... 1 UNDERSTANDING PAIN ................................................................................................ 2 Pain ............................................................................................................................. 2 Acute and Chronic Pain ............................................................................................... 3 Nociceptive and Neuropathic Pain ............................................................................... 3 Cancer and Non-Cancer Pain ...................................................................................... 3 Tolerance, Dependence and Addiction ........................................................................ 4 Pain as an Illness......................................................................................................... 4 SPECIAL PATIENT POPULATIONS............................................................................... 4 Acute Pain ................................................................................................................... 4 Emergency -
Double-Blind Crossover Trial of Oral Meptazinol, Pentazocine and Placebo in the Treatment of Pain in the Elderly V
Postgrad Med J: first published as 10.1136/pgmj.56.657.474 on 1 July 1980. Downloaded from Postgraduate Medical Journal (July 1980) 56, 474-477 Double-blind crossover trial of oral meptazinol, pentazocine and placebo in the treatment of pain in the elderly V. PEARCE P. J. ROBSON M.B. B.S., M.R.C.P. M.B. B.S., M.R.C.P. Chesterton Hospital, Cambridge and Wyeth Laboratories, Maidenhead, Berkshire Summary unit, pentazocine 25 mg orally, and placebo. The 2 In a randomized, double-blind crossover trial in 30 active drugs were given in deliberately small doses elderly patients suffering from moderate to severe as it is well recognized that age is highly correlated pain, the analgesic efficacy, tendency to produce with the pain relief obtained from a given dose of mental confusion and side effect profile of meptazinol analgesic (Beliville et al., 1971) and that the elderly 100 mg orally were compared with those of pentazo- are more susceptible to drugs in general (Leading cine 25 mg orally and placebo. Article, 1977). Both the active drugs produced significantly better analgesia than placebo but meptazinol also provided Materials and methods significantly better pain relief than pentazocine, This was a randomized double-blind crossover whilst at the same time causing less mental confusion. trial in 30 patients over the age of 70 years who had Side effects were unremarkable. given informed consent to participate and whocopyright. Meptazinol appears to be a better general purpose would in any case have required a potent oral anal- oral analgesic in this group of patients than penta- gesic.