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METHODICAL GUIDANCE for the Lecture Academic Subject Human
Ministry of Public Health of Ukraine Ukrainian Medical Stomatological Academy "Approved" at the meeting of the Department of Human Anatomy «29» 08 2020 Minutes № Head of the Department Professor O.O. Sherstjuk ________________________ METHODICAL GUIDANCE for the lecture Academic subject Human Anatomy Module No 3 "The heart. Vessels and nerves of the head, the neck, the trunk, extremities" Lecture No 15 Review of the autonomic nervous system, its central departments. The principles of the autonomic innervation of the organs Year of study ІI Faculty Foreign students' training faculty, specialty «Medicine» Number of 2 academic hours Poltava – 2020 1. Educational basis of the topic The autonomic division of peripheral nervous system regulates physiological processes of the human organism like blood circulation, respiration, digestion, excretion and general metabolism; also, it regulates tissue trophic processes. The autonomic division acts relatively independently from the cerebral cortex and the organs supplied act involuntarily as well. It is quite clear that that distinguishing of the somatic and the autonomic compartments is conditional and exact delimitation is not possible. Such impossibility appears due to common regulatory centers for both divisions and tight morphological and functional associations featured by them. The somatic neurons and the interneurons of PNS like those of CNS feature topographical and synaptic associations so a reflex arc may comprise both somatic (e.g. afferent) and autonomic neurons. Summarizing the aforesaid, the term ’autonomic nervous system’ will be applied to a specific compartment of PNS but not for a separate nervous system. 2. Learning objectives of the lecture: . to familiarize students with the autonomic division of CNS; . -
Autonomic Nervous System
AUTONOMIC NERVOUS SYSTEM PAGE 1 AUTONOMIC NERVOUS SYSTEM PAGE 2 AUTONOMIC NERVOUS SYSTEM PAGE 3 AUTONOMIC NERVOUS SYSTEM PAGE 4 AUTONOMIC NERVOUS SYSTEM PAGE 5 AUTONOMIC NERVOUS SYSTEM PAGE 6 AUTONOMIC NERVOUS SYSTEM PAGE 7 AUTONOMIC NERVOUS SYSTEM PAGE 8 AUTONOMIC NERVOUS SYSTEM PAGE 9 REVIEW QUESTIONS 1. The autonomic nervous system controls the activity of _?_. (a) smooth muscle (b) cardiac muscle (c) glands (d) all of these (e) none of these 2. All preganglionic and postganglionic autonomic neurons are _?_ neurons. (a) somatic efferent (b) visceral efferent (c) somatic afferent (d) visceral afferent (e) association neurons 3. Which neurotransmitter is released at the synapses between preganglionic and postganglionic autonomic neurons ? (a) epinephrine (b) norepinephrine (c) acetylcholine (d) serotonin (e) oxytocin 4. All preganglionic sympathetic neurons are located in: (a) the lateral horn of the spinal cord of spinal cord segments T1-L2 (b) brainstem nuclei (c) intramural (terminal) ganglia (d) paravertebral ganglia of the sympathetic chains (e) prevertebral ganglia 5. All preganglionic parasympathetic neurons are located in _?_. (a) prevertebral ganglia (b) the lateral horn of spinal cord segments T1-L2 (c) sympathetic chain ganglia (d) intramural ganglia (e) brainstem nuclei and spinal cord segments S2-S4 6. Prevertebral and paravertebral ganglia contain _?_. (a) preganglionic sympathetic neurons (b) preganglionic parasympathetic neurons (c) postganglionic sympathetic neurons (d) postganglionic parasympathetic neurons (e) all of these 7. The otic, ciliary, submandibular and pterygopalatine ganglia are located in the head region and contain _?_. (a) preganglionic sympathetic neurons (b) preganglionic parasympathetic neurons (c) postganglionic sympathetic neurons (d) postganglionic parasympathetic neurons (e) none of these 8. -
Medical Study Center
https://www.facebook.com/Medicalstudycenter2012 https://www.facebook.com/Medicalstudycenter2012 Notes On CNS Physiology Gray Matter of Spinal Cord: in the spinal cord gray matter is in the form of H shaped pillars which can be divided into three types of columns i.e. anterior horn or ventral horn, posterior horn or dorsal horn and in segments from T1 to L2 there is lateral horn. Neurons in these horns are Ventral Horn: Two groups of neurons Alpha motor neurons which are large multi polar neurons and their nerve fibers are alpha efferents which innervate skeletal muscle. Gamma neurons present in ventral horn are small and multi polar neurons and there nerve fibers are gamma efferents which innervate the intrafusal fibers of the muscle spindles. Both these alpha and gamma efferents come out of the spinal cord through ventral root of spinal nerves. Dorsal Horn: there are 4 groups of neurons 1. Substantia gelatinosa: this group of neurons is present at the apex of the posterior gray column. These neurons receive afferent nerve fibers carrying impulses of pain, temperature and crude touch. 2. Nucleus Proprius: this group is located anterior to the first group. These neurons receive afferent nerve fibers carrying impulses of proprioception and two point tactile discrimination. 3. Clarke’s column or nucleus dorsalis: this group is present at the base of the posterior gray column. These neurons are present in segments from T1 to L3, 4. These neurons are part of spinocerebellar tract and these receive afferent nerve fibers from spinocerebellar tract. 4. Visceral Afferent Nucleus: Present at the base of the posterior horn lateral to the clarke’s column. -
Acupuncture and Pain Management
IN-DEPTH: INTEGRATIVE MEDICINE (COMPLEMENTARY & ALTERNATIVE MEDICINE) Acupuncture and Pain Management James D. Kenney, DVM There is a large and expanding body of scientific evidence supporting the use of acupuncture in pain management. In the last decade, our understanding of how the brain processes acupuncture anal- gesia has undergone considerable development. Profound studies on neural mechanisms underlying acupuncture analgesia have evolved rapidly and predominately focus on cellular and molecular substrate and functional brain imaging. The currently understood mechanisms of acupuncture analgesia are complex and involve direct and indirect neurohumoral effects that block pain percep- tion, reduce the pain response, relieve muscle spasms, and reduce inflammation. The analgesic mechanisms of acupuncture involve the spinal cord grey matter, hypothalamic-pituitary axis, mid- brain periaqueductal grey matter, medulla oblongata, limbic system, cerebral cortex, and autonomic nervous system. Electroacupuncture (EA) stimulation of these sites results in activation of descend- ing pathways that inhibit pain through endogenous opioid, noradrenergic, and serotonergic sys- tems. There are growing numbers of human trials supporting the use of acupuncture as an evidence- based practice for pain management in human medicine. There are many studies that support the efficacy of acupuncture for low back pain, neck pain, chronic idiopathic and migraine headaches, knee pain, shoulder pain, fibromyalgia, temporomandibular joint pain, and postoperative pain. Although the number of well-designed, controlled clinical research studies in veterinary medicine is lagging behind the number of studies in human medicine, much of the basic science research has been done in animals with neurophysiology that is more similar to veterinary patients than humans. Although there is research to support EA as an evidence-based practice for the control of back pain in horses, additional studies are needed in other clinical situations in veterinary medicine where pain manage- ment is required. -
Thesis Comprises Only My Original Work Towards the Doctor of Philosophy Except Where Indicated in the Preface;
Development, prevalence and treatment of blood pressure abnormalities in spinal cord injury Min Yin Goh ORCID: 0000-0003-2517-7745 Doctor of Philosophy August 2019 Department of Medicine, Austin Health Faculty of Medicine, Dentistry and Health Sciences The University of Melbourne Submitted in total fulfilment of the requirements of the degree of Doctor of Philosophy Abstract Disorders of blood pressure control arise from disruption of the autonomic nervous system and result in symptomatic orthostatic hypotension and large fluctuations in blood pressure. Ambulatory blood pressure monitoring is used in the general population for assessment of blood pressure control and to detect episodes of hypotension. In spinal cord injury (SCI), impaired control of the sympathetic nervous system leads to orthostatic intolerance and autonomic dysreflexia. Smaller studies in restricted populations have examined ambulatory pressures in SCI and observed abnormalities in diurnal blood pressure variation in complete cervical SCI. Altered diurnal blood pressure is associated with abnormalities in diurnal urine production and orthostatic intolerance in autonomic failure. This triad may also occur in SCI to explain the orthostatic intolerance. A retrospective examination of ambulatory pressures of patients with SCI referred for clinically significant blood pressure disorders revealed a high prevalence of abnormalities in diurnal blood pressure and urine production in acute and chronic tetraplegia and in acute paraplegia. To characterise the course of diurnal blood pressure, urine production and orthostatic symptoms in SCI, two prospective studies were performed. First, consecutive patients admitted with acute SCI were screened for recruitment, and consenting volunteers were compared with immobilised and mobilising controls. In the second study, people with chronic SCI (>1 year) living in the community were compared with mobilising controls. -
Neuronal Types and Their Specification Dynamics in the Autonomic Nervous System
From the Department of Medical Biochemistry and Biophysics Karolinska Institutet, Stockholm, Sweden NEURONAL TYPES AND THEIR SPECIFICATION DYNAMICS IN THE AUTONOMIC NERVOUS SYSTEM Alessandro Furlan Stockholm 2016 All previously published papers were reproduced with permission from the publisher. Published by Karolinska Institutet. Printed by E-Print AB © Alessandro Furlan, 2016 ISBN 978-91-7676-419-0 On the cover: abstract illustration of sympathetic neurons extending their axons Credits: Gioele La Manno NEURONAL TYPES AND THEIR SPECIFICATION DYNAMICS IN THE AUTONOMIC NERVOUS SYSTEM THESIS FOR DOCTORAL DEGREE (Ph.D.) By Alessandro Furlan Principal Supervisor: Opponent: Prof. Patrik Ernfors Prof. Hermann Rohrer Karolinska Institutet Max Planck Institute for Brain Research Department of Medical Biochemistry and Research Group Developmental Neurobiology Biophysics Division of Molecular Neurobiology Examination Board: Prof. Jonas Muhr Co-supervisor(s): Karolinska Institutet Prof. Ola Hermansson Department of Cell and Molecular Biology Karolinska Institutet Department of Neuroscience Prof. Tomas Hökfelt Karolinska Institutet Assistant Prof. Francois Lallemend Department of Neuroscience Karolinska Institutet Division of Chemical Neurotransmission Department of Neuroscience Prof. Ted Ebedal Uppsala University Department of Neuroscience Division of Developmental Neuroscience To my parents ABSTRACT The autonomic nervous system is formed by a sympathetic and a parasympathetic division that have complementary roles in the maintenance of body homeostasis. Autonomic neurons, also known as visceral motor neurons, are tonically active and innervate virtually every organ in our body. For instance, cardiac outflow, thermoregulation and even the focusing of our eyes are just some of the plethora of physiological functions under the control of this system. Consequently, perturbation of autonomic nervous system activity can lead to a broad spectrum of disorders collectively known as dysautonomia and other diseases such as hypertension. -
Facsimile Del Frontespizio Della Tesi Di Dottorato
Allma Mater Studiiorum – Uniiversiità dii Bollogna DOTTORATO DI RICERCA IN SCIENZE MEDICHE VETERINARIE Ciclo XXIX° Settore Concorsuale di afferenza: 07/H1 Settore Scientifico disciplinare: VET 01 The nervous system of Delphinidae: neurochemical studies on different central and peripheral regions Presentata da: Anna Maria Rambaldi Coordinatore Dottorato Relatore Chiar.mo Prof. Arcangelo Gentile Chiar.mo Prof. Cristiano Bombardi Esame finale anno 2017 The nervous system of Delphinidae: neurochemical studies on different central and peripheral regions INDEX ABSTRACT 1 INTRODUCTION 7 1 Cetaceans and general adaptations to aquatic environment 8 2 The nervous system of cetaceans 11 2.1 Evolution 11 2.2 The central nervous system 14 2.3 The peripheral nervous system 23 EXPERIMENTAL STUDIES 25 3 Distribution of calretinin immunoreactivity in the lateral nucleus of the 26 bottlenose dolphin (Tursiops truncatus) amygdala 4 Calcitonin gene-related peptide (CGRP) expression in the spinal cord and 41 spinal ganglia of the bottlenose dolphin (Tursiops truncatus) 5 Nitrergic and substance P immunoreactive neurons in the enteric nervous 58 system of the bottlenose dolphin (Tursiops truncatus) intestine 6 Preliminary study on the expression of calcium binding proteins and 72 neuronal nitric oxide synthase (nNOS) in different brain regions of striped dolphins (Stenella Coeruleoalba) affected by morbillivirus CONCLUSIONS 91 REFERENCES 94 ABSTRACT During the evolutionary path, Cetaceans experienced a return to waters and hence had to adapt many of their anatomical and physiological features to this new life. Many organs and systems present several modifications and specialisations, which make these mammals different from their mainland ancestors. The nervous system either displays peculiar features like an extremely large brain, in terms of both absolute and relative mass, a very high level of gyrification, a minimization, or in some cases a complete lack, of olfactory structures, and a poorly developed corpus callosum. -
Thesis Rests with the Author
University of Bath PHD Studies on the alpha-bungarotoxin binding component in human brain. Whyte, J. Award date: 1985 Awarding institution: University of Bath Link to publication Alternative formats If you require this document in an alternative format, please contact: [email protected] General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Download date: 10. Oct. 2021 i Ta \ D'--- V ^ STUDIES ON THE a-BUNGAROTOXIN BINDING COMPONENT IN HUMAN BRAIN submitted by J. Whyte for the degree of Ph.D. of the University of Bath 1985 COPYRIGHT Attention is drawn to the fact that the copyright of this thesis rests with the author. This copy of the thesis has been supplied on condition that anyone who consults it is under stood to recognize that its copyright rests with the author and that no quotation from the thesis and no information derived from it may be published without the prior written consent of the author. -
Autonomic Nervous System
Autonomic nervous System Regulates activity of: Smooth muscle Cardiac muscle certain glands Autonomic- illusory (convenient)-not under direct control Regulated by: hypothalamus Medulla oblongata Divided in to two subdivisions: Sympathetic Parasympathetic Sympathetic: mobilizes all the resources of body in an emergency Parasympathetic: maintains the normal body functions Complimentary to each other. ANS Activity expressed • Regulation of Blood Pressure • Regulation of Body Temperature • Cardio-respiratory rate • Gastro-intestinal motility • Glandular Secretion Sensations • General – Hunger , Thirst , Nausea • Special -- Smell, taste and visceral pain • Location of ANS in CNS: 1. cerebral hemispheres (limbic system) 2. Brain stem (general visceral nuclei of cranial nerves) 3. Spinal cord (intermediate grey column) ANS Anatomy • Pathway: Two motor neurons 1. In CNS -->Axon-->Autonomic ganglion 2. In Autonomic ganglion-->Axon-->effector organ • Anatomy: Preganglionic neuron--->preganglionic fibre (myelinated axon)--->out of CNS as a part of cranial/spinal nerve--->fibres separate & extend to ANS ganglion-->synapse with postganglionic neuron--->postganglionic fibre (nonmyelinated)-- >effector organ Sympathetic system Components • Pair of ganglionic sympathetic trunk • Communicating rami • Branches • Plexuses • Subsidiary ganglia – collateral , terminal ganglia Sympathetic trunk (lateral ganglia) • Paravertebral in position • Extend from base of skull to coccygeal • Both trunk unite to form – ganglion impar Total Ganglia • Cervical-3 • Thoracic-11 -
DESCENDING TRACTS Descending Tracts Have Three Neurons
Neuroanatomy Luka Tomšič Ahčin Bell’s Palsy Neuroanatomy Written: 2 October 2010 DESCENDING TRACTS Descending tracts have three neurons: 1. 1st order neurons (UMN): cell bodies are in the cerebral cortex and other supra spinal areas 2. 2nd order neurons: short and situated in the anterior grey column of the spinal cord 3. 3rd order neuron (LMN): situated in the anterior grey column and innervate the skeletal muscles through anterior roots of the spinal nerves Corticospinal tract: rapid, skilled and voluntary movements 1st order neuron Axons arise from the pyramidal cells of the cerebral cortex (situated in the 5th layer), 2/3 from the pre central gyrus and 1/3 from the post central gyrus: 1. 1/3 of fibers arise from the 1stry motor !!cortex (Area 4) 2. 1/3 of fibers arise from the 2ndry motor !!cortex (Area 6) 3. 1/3 of fibers arise from the parietal lobe ! (Area 1, 2 and 3). Descending fibers converge in the corona radiata and pass though the posterior limb of the internal capsule; organization of fibers within the internal capsule: 1. close to genu (medial): concerned with the cervical parts of the body 2. away from the genu (lateral): concerned with the lower extremity. 1! Bell’s Palsy http://bellspalsycranialnerves.wordpress.com/ Neuroanatomy The tract then passes through the middle 3/5 of the basis pedunculi of the midbrain; organization of fibers in the midbrain: 1. medially: cervical parts of the body 2. laterally: lower limbs. When the tract enters the pons, it's broken into many bundles by the transverse pontocerebellar fibers. -
LRRK2 Is Expressed in Areas Affected by Parkinson's Disease in the Adult
Simón-Sánchez, 1 LRRK2 is expressed in areas affected by Parkinson’s disease in the adult mouse brain Javier Simón-Sánchez1, Vicente Herranz-Pérez1, Francisco Olucha- Bordonau2, Jordi Pérez-Tur1, * 1. Unitat de Genètica Molecular. Departament de Genòmica i Proteòmica. Institut de Biomedicina de València-CSIC. 2. Departament d’Anatomia i Embriologia Humana. Facultat de Medicina. Universitat de València-Estudi General. *: Address for correspondence at: Unitat de Genètica Molecular. Institut de Biomedicina de València-CSIC. C/ Jaume Roig, 11. E46010 València (Spain). Telephone: +34 96 339 1755 Fax: +34 96 339 3774 e-mail: [email protected] Running title: Expression of LRRK2 in the Adult Mouse Brain pages; 4 figures; 2 tables. Word count: manuscript: 4,314 words; abstract: 179 words; introduction: 515 words. Simón-Sánchez, 2 ABSTRACT The LRRK2 gene was recently found to have multiple mutations that are causative for autosomal dominant inherited Parkinson´s disease (PD). Previously, we used Northern blot analysis to show that that this gene was expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe and caudate putamen. However, a more comprehensive map of LRRK2 mRNA localization in the central nervous system is still lacking. In this study we have mapped the distribution of the mRNA encoding for LRRK2 using non-radioactive in situ hybridization. We detected a moderate expression of this PD-related gene throughout the adult mouse brain. A stronger hybridization signal was observed in deep cerebral cortex layers, superficial cingulate cortex layers, the piriform cortex, hippocampal formation, caudate putamen, substantia nigra, the basolateral and basomedial anterior amygdala nuclei, reticular thalamic nucleus and also in the cerebellar granular cell layer. -
The LIM-Homeobox Gene Lhx8 Is Required for the Development of Many Cholinergic Neurons in the Mouse Forebrain
The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain Yangu Zhao*, Oscar Marı´n†‡, Edit Hermesz*§, Aaron Powell*, Nuria Flames†‡, Miklo´ s Palkovits¶, John L. R. Rubenstein†, and Heiner Westphal*ʈ *Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892; †Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, University of California, San Francisco, CA 94143; §Department of Biochemistry, University of Szeged, P.O. Box 533, H-6701 Szeged, Hungary; and ¶Laboratory of Neuromorphology, Semmelweis University, Tu¨zolto´utca 58, H-1094 Budapest, Hungary Edited by Joshua R. Sanes, Washington University School of Medicine, St. Louis, MO, and approved June 2, 2003 (received for review December 30, 2002) Forebrain cholinergic neurons play important roles as striatal local circuit neurons and basal telencephalic projection neurons. The genetic mechanisms that control development of these neurons suggest that most of them are derived from the basal telenceph- alon where Lhx8, a LIM-homeobox gene, is expressed. Here we report that mice with a null mutation of Lhx8 are deficient in the development of forebrain cholinergic neurons. Lhx8 mutants lack the nucleus basalis, a major source of the cholinergic input to the cerebral cortex. In addition, the number of cholinergic neurons is Fig. 1. In situ analysis of Lhx8 mRNA expression in the developing mouse reduced in several other areas of the subcortical forebrain in Lhx8 basal forebrain. (A and B) Lhx8 expression in the MGE and POa (PO) of E11.5 mutants, including the caudate-putamen, medial septal nucleus, (A) and E12.5 (B) mouse embryos.