COMMUNITY REPORT 2015-2016

A PLACE WHERE EVERY CHILD CAN ACCESS THE FINEST, MOST ADVANCED MEDICAL CARE FROM SOME OF THE TOP DOCTORS IN THEIR FIELDS. IMAGINE A PLACE WHERE RARE IS FAMILIAR. WHERE THERE’S NO SUCH THING AS UNTREATABLE, UNIMAGINABLE OR IMPOSSIBLE. WHERE EVERY DAY, NEVER-BEFORE-SEEN TREATMENTS BECOME THE GOLD-STANDARD AND OUR PHYSICIAN-SCIENTISTS ARE UNLOCKING NEW POSSIBILITIES FOR FUTURE GENERATIONS OF CHILDREN.

IMAGINE A PLACE WHERE ANYTHING IS POSSIBLE. President John Kennedy lit America’s imagination on fire with his bold vision of landing astronauts on the moon in a decade’s time.

Imagination is what a child employs when she tells an adult she wants to be a veterinarian or a princess. It’s what our Child Life Department taps into when they do medical play with patients to help them understand a procedure they’re about to undergo. At Children’s Hospital of Pittsburgh of UPMC, and free from stigma. And each is made possible, we value imagination. We want to think big. or made better, with philanthropic support. We want our physicians, families, staff members, volunteers, and donors to think big. “Thinking In short, we couldn’t fulfill our mission without big” developed the polio vaccine, introduced the financial support that comes from our and perfected organ transplantation as a community, both in big and small ways. Your lifesaving therapy, and discovered a cure generosity gives our physicians and researchers for a rare liver disease. the chance to dream. It gives parents the space to hope, at what could be their moment of In this Community Report, you’ll meet some greatest need. It gives our children the ability to of Children’s Hospital’s most imaginative imagine a future like any other child’s. is what a child employs thinkers. They are physicians, scientists, and administrators, and in big and small ways they’re So with gratitude, we ask you to enjoy this changing the world around us. They are fighting glance back at our achievements through brain cancer with a vaccine, regenerating fiscal year 2016. Then join us with eyes diseased heart tissue, and treating kids’ and teens’ forward as we imagine what we might mental health issues in a way that’s full of respect accomplish next.

J. Gregory Barrett, President Christopher Gessner, President Children’s Hospital of Pittsburgh Foundation Children’s Hospital of Pittsburgh of UPMC HEALING BROKEN HEARTS

A FAMILY HOLDS CHILDREN’S CLOSE TO THEIR HEART When John and Cathy Pelusi’s youngest child, Jodie, came to Children’s for surgery to correct her ventricular septal defect (VSD), a hole in the wall separating the two lower chambers of the heart, she was only 6 years old. The Pelusis say the level of care was outstanding — they realized how lucky they were to have Children’s skilled doctors and nurses repair Jodie’s heart defect, and they knew that other children with even more serious issues were being cured. Today, Jodie is a thriving, caring young adult with a big heart, working as a Peace Corps volunteer in Cameroon. Her family remains grateful for the wonderful cardiac care she received. For more than 15 years, the Pelusi family has supported the Cardiac Research Fund in honor of Jodie to honor Children’s and the wonderful things it does in the community.

Bernhard Kühn, MD THE RICHARD KING MELLON FOUNDATION INSTITUTE FOR PEDIATRIC RESEARCH ENABLES PROMISING PHYSICIAN-SCIENTISTS TO PURSUE LONG-TERM, AND SOMETIMES LONG-SHOT, GROUNDBREAKING MEDICAL ADVANCES. IN SHORT, THE PROGRAM BROKEN FUNDS PHYSICIAN-SCIENTISTS WITH BIG DREAMS.

Bernhard Kühn, MD, is a Mellon Scholar with a Dr. Kühn realized this stimulant potentially “Regenerative medicine, by definition, should colossal dream: to help the heart regenerate. could be used in therapies to trigger heart cells help you get better permanently. When you absent through disease or congenital defect, come off the medicine, you should stay better,” “As a field, we understand how to fix faulty to grow anew. he says. “This is a game changer in how heart blood flow in the heart,” says Dr. Kühn, “But disease is dealt with because we have the what we have not figured out is how to restore Now, Dr. Kühn is working toward that goal. potential to stop the progression and partially heart muscle that is damaged, diseased, or His lab has already yielded insights into the revert the disease.” might not have grown.” growth mechanisms of heart cells. The next step will be to develop strategies for clinical When asked where he would imagine his work Scientists have long believed that, after a trials in children with damaged hearts or could lead, he responds simply, “Saving lives. baby is born, the human heart cannot certain congenital heart defects. Dr. Kühn How many times does a researcher get to make regenerate itself. says the drug is most likely to be effective in a direct impact on patient care? For many the youngest patients, whose hearts are still researchers, once in a lifetime; for most, never. developing. If I can help bring a new therapy to children That was, until a few years ago, when Dr. Kühn — that would be something I could look back published a landmark paper in the prestigious on and say, this was a professional life worth journal Cell, which showed heart muscle cells “We’re hoping developments continue to living.” do proliferate during early development be positive, we maintain a good safety profile, after birth — raising the possibility that and to have clinical trials soon. But this drug scientists could stimulate new cell growth has theoretical, not proven benefits, so we in human infants. must be very careful. We want to be quick, but we must be safe,” he says. He identified the growth factor neuregulin-1 as the stimulant that encourages heart muscle While Dr. Kühn is cautious about the cells to divide. overstating the benefits, he admits the drug has the potential to be revolutionary. IMAGINEHARNESSING THE POWER OF A CHILD’S IMMUNE TO FIGHT THE SCARIEST SYSTEM BRAIN TUMORS

Ian Pollack, MD

WWE FAN INSPIRES HEAVYWEIGHT RESEARCH WWE (World Wrestling Entertainment Inc.) executives Stephanie McMahon and Paul “Triple H” Levesque’s lives were forever changed by super fan Connor “The Crusher” Michalek, an 8-year-old battling a rare brain and spinal cord tumor called medulloblastoma. When Connor lost his battle to medulloblastoma, Stephanie and Paul decided to keep the fight going by creating Connor’s Cure. In 2015, 1,328 donors, including WWE fans across the globe, contributed $578,219.56 to Connor’s Cure. Today, in partnership with The V Foundation for Cancer Research, Connor’s Cure provides support to leading research hospitals from across the country including Children’s Hospital. WHAT IF A VACCINE COULD BOOST THE BODY’S ABILITY TO FIGHT CANCER? IMAGINE THE HOPE IT WOULD BRING TO THOUSANDS OF CHILDREN WHO WEREN’T RESPONDING TO STANDARD THERAPIES, AND THEIR FAMILIES.

(Left to right) Brent, Olivia, Lance, and Christine Hupkovich. Lance is a participant in one of the vaccine trials.

Sounds like pie-in-the sky stuff, but Brain tumor treatment is very difficult. One little girl from Minnesota has responded immunotherapy is here. And for years, Chemotherapy and radiation treatment can really well to immunotherapy. She’s now 2. “The Children’s Hospital of Pittsburgh of UPMC has only do so much, and surgery often is not an tumor has shrunk over time, and she’s been been leading the way. option. Immunotherapies show promise for able to walk and get better since being on the brain tumors that are difficult to treat. vaccine. It’s been wonderful to see.” In 2009, the lab of Ian Pollack, MD, chief of the Division of Pediatric Neurosurgery, first Unlike chemotherapy, immunotherapy has few What does the future hold for immunotherapy? identified antigens on tumor cells that could be side affects. The most common are a minor rash Maybe it will become a first-course therapy used as a vaccine. When an early study of this at the injection site and fever within the first for brain tumors, instead of a last-ditch effort. approach proved successful in adults, the team 24 hours. Maybe it will work synergistically with other moved on to kids. standard therapies. Whatever the case may be, Pediatric patients come from all over the Children’s is committed to moving the Today, Children’s Hospital has three open nation to participate in Children’s clinical trials, needle forward. clinical trials — for high-grade glioma, including Oregon, the Midwest, and North low-grade glioma, and ependymoma — all Carolina. Since Dr. Pollack’s first trial, more than types of brain tumor. To qualify, a patient must 70 patients, ages 1 to 21, have enrolled. have failed up to five other therapies. STRONG ALLIES The Alliance for a Healthier Generation, founded by the American Heart Association and the Clinton Foundation has been an instrumental partner in initiating the Healthy Schools program locally. The Alliance takes a comprehensive approach to building healthier learning environments and offers free technical support to participating schools.

GETS O A

H N

W A for their efforts?

Pittsburgh Arsenal 6–8 Pittsburgh Arsenal PreK–5 Pittsburgh Brashear 9–12 Pittsburgh Dilworth PreK–5 Pittsburgh Faison K–5 Pittsburgh Langley K–8 Pittsburgh Minadeo K–5 Pittsburgh Montessori PreK–5 Pittsburgh Sterrett 6–8 Pittsburgh Woolslair PreK–5 WHAT IF ALL STUDENTS HAD ACCESS TO ENVIRONMENTS THAT PROMOTED HEALTHY EATING AND ACTIVE LIVING?

Megan Perfetti is a Brashear health and NO WHAT IFS. WE’RE physical education instructor who supervises health and physical education in the district. MAKING SURE THAT “We have a lot of hands on deck implementing the Healthy Schools Program. This is a whole HEALTHIER LIVING IS faculty buy-in,” said Ms. Perfetti.

BEING ACTIVATED IN Consistency and keeping things fun is key. Rob Aleva, another Brashear phys ed instructor, THE SCHOOLS IN OUR said, “It’s nice to see those ‘aha’ moments’ when you say something, and then see the look on a BACKYARD. student’s face that says … I get it.”

As part of Children’s Community Benefit “It’s been a great initiative thus far,” Ms. Kuchera Initiative, Children’s Hospital of Pittsburgh of said. “We’re looking forward to expanding UPMC has welcomed working with the Alliance into more schools, and identifying additional for a Healthier Generation. We embrace our ways Children’s can support student health role as local manager of the Alliance’s national and achievement.” Healthy Schools Program.

Interest in the Healthy Schools Program In 2014–15, 10 Pittsburgh Public Schools chose continues to grow, almost as fast as the kids to enroll in the Healthy Schools program — a themselves. Already, 19 Pittsburgh Public program designed to help schools create, Schools have signed on for the coming year. implement, and sustain healthy environments. Participating schools were challenged to complete a health assessment, which helped “You increase nutrition, you increase them identify their priority areas and then movement, and you’re going to increase test develop individualized action plans for making scores. And that’s what we want to do,” said their schools more health-promoting places for Ms. Perfetti. students and staff.

“At Children’s Hospital, we serve as the catalysts of positive change. But it’s really the schools that are doing the work and deserve all the credit,” said Anne Marie Kuchera, project director for Children’s Community Benefit Initiatives.

Brashear 9–12 has implemented everything from a walking roll call and healthy fundraisers to nutritious taste tests and sports activities between students and staff. For the steps they’ve taken, they’re eligible for a national Healthy Schools Award.

Anne Marie Kuchera, MS, MA, RD, LPC TREATING RARE DISEASES HIDDEN IN PLAIN SIGHT

CLEVELANDS LOVE PITTSBURGH In January 2015, the Cleveland family made a generous gift to Children’s to establish the Cleveland Family Endowed Chair in Pediatric Research. By supporting Dr. Vockley’s research the family hopes to advance new therapies for children living with debilitating and difficult-to-treat genetic conditions. The Clevelands’ steadfast commitment to Children’s extends back to 2006. They remain committed to investing in Children’s Hospital to give hope to families here in Pittsburgh, and to families everywhere.

Jerry Vockley, MD, PhD A GOOD HOSPITAL TREATS THE NEEDS OF ITS PATIENTS. A GREAT HOSPITAL RECOGNIZES THE NEEDS OF ITS PATIENTS, AND PLANS TAILORED CARE BEFORE IT IS NEEDED.

On a patient level, it’s called personalized information to about 30 family members. sect communities,” says Dr. Vockley, who is medicine. On a community level, it’s the idea Most of the family members agreed to genetic developing a database of known diseases behind Children’s Hospital’s Plain Communities testing. affecting Plain people in western Pennsylvania Translational Medicine Program. and eastern Ohio to complement similar efforts Genetic testing revealed that over a dozen in eastern Pennsylvania. “Now when a patient Western Pennsylvania’s Plain sect communities, relatives were affected, some who had from those communities walks in our door, both Amish and Mennonite, are the been seen at other hospitals for symptoms we can look at that database and ask descendants of small groups of immigrants. consistent with MELAS, but had not yet ourselves, ‘OK, what are these symptoms Because of their limited founder population, been diagnosed. consistent with?’ they have a unique spectrum of genetic diseases. In this region, they travel to Pittsburgh “We realized that there was more going on, “Similar clinics are also springing up around the for specialty care, often at great expense. and that we needed to think in a more country,” says Dr. Vockley. “Now we’re working integrated fashion,” said Dr. Vockley. with them to develop a national effort to The need to focus on these communities as diagnose and care for these populations.” a group came into sharp focus after Jerry This realization was part of the impetus behind Vockley, MD, PhD, chief of Medical Genetics, the Plain Communities Translational Medicine Dr. Vockley explains the program is part of a and child neurologist Amy Goldstein, Program, which includes Medical Genetics bigger effort, “We’re always imagining new MD, diagnosed Martha, a 15-year-old care at the Children’s Specialty Care Center ways to be able to diagnose — specifically, Amish girl, with a rare and serious genetic Hermitage and improved coordination of care accurately, and early — diseases that may disease, a mitochondrial disorder known as throughout the Children’s system. There also have adverse outcomes in children and young mitochondrial encephalopathy with lactic are ongoing collaborations with community adults. And develop better therapies for acidosis and stroke-like episodes (MELAS) that clinics like the Clinic for Special Children in patients with these diseases.” is passed through the maternal line. Strasburg, Pennsylvania, and the Central Pennsylvania Clinic in Belleville. Dr. Vockley, who also is medical director of the Center for Rare Disease Therapy at Children’s, Patients seen through the Plain Communities knew that other members of Martha’s family Translational Medicine Program receive would be at risk for the congenital disease. culturally sensitive care at a significant reduction in cost. He and his team obtained permission from the community’s deacon to meet with “We have identified genetic testing options Martha’s extended family, and they presented to diagnose disorders specific to the Plain D WIN AN AWARD-WINNING BEHAVIORAL HEALTH PROGRAM. R N FOR EVERYTHING FROM ANXIETY AND DEPRESSION TO ADHD AND OBSESSIVE COMPULSIVE BEHAVIORS. A E

R Bronze Award: The Fine Awards for Teamwork Excellence in Health W

A Award for Innovation: The Hospital Association of Pennsylvania Silver Award for Psychiatric Services: The American Psychiatric Society

TEACHING PHYSICIANS WELL. SUBSTANCE ABUSE PROBLEMS START YOUNG. A grant from the Staunton Farm Foundation has educated SO LET’S SCREEN YOUNG. physicians on how to treat depression and anxiety. After A Sewickley women’s group, the Child Health Association of attending a voluntary four-part series, 50 percent changed Sewickley, has funded a pilot program for substance abuse their practice behavior based on what they learned about screenings in 11- to 17-year-olds. In three offices, over 1,000 evidence-based medicine. screenings were done in the first six months. IMAGINE IF EVERY KID HAD ACCESS TO THE RIGHT BEHAVIORAL HEALTH CARE, AT THE RIGHT TIME AND IN THE RIGHT PLACE.

RECOGNIZING THAT AN INCREASING NUMBER OF KIDS WEREN’T GETTING THE BEHAVIORAL HEALTH SUPPORT THEY NEEDED, CHILDREN’S COMMUNITY PEDIATRICS (CCP), A SUBSIDIARY OF CHILDREN’S HOSPITAL OF PITTSBURGH OF UPMC, HAS MADE PEDIATRIC BEHAVIORAL HEALTH A PRIORITY.

“Children’s is really ahead of the curve Pediatric behavioral health care is now in building an integrated system,” said available in 20 locations across western Abigail Schlesinger, MD, clinical director of Pennsylvania, including at most CCP offices Community Services for the Behavioral Science and with hubs at Children’s Pine Center and Division of Children’s Hospital. “We’ve been Children’s South. As the program grows, recognized on the local, state, and national therapists and psychiatrists will be embedded level for providing an innovative model of care.” in even more sites, including in Erie.

CCP’s Behavioral Health Program provides CCP’s Behavioral Health Program reported early access to integrated behavioral health over 12,000 visits this year. It boasts a 90 services right in the pediatrician’s office. Having percent show rate; at standalone community a behavioral health care provider on site helps behavioral health providers, the show rate can reduce the stigma that can keep patients from be as low as 50 percent. seeking mental health care. And it raises the comfort level of pediatricians — giving them a The program is embraced by children, families, behavioral health expert to collaborate with in pediatricians, psychiatrists, and therapists alike. the practice. And why not?

“Our goal is to get kids early, identify their It’s helping kids get the behavioral health care needs, and provide treatment right in the they need, when they need it most. pediatric primary care office. But if a child needs more care or needs a specialist, we get Sooner, rather than later. him there,” said Dr. Schlesinger.

Dr. Schlesinger helped develop and implement the program in concert with a leadership team from CCP, Children’s Hospital, and Western Psychiatric Institute and Clinic of UPMC. She’s devoted her career to improving how we talk about and treat mental health issues.

Abigail Schlesinger, MD IT’S NOT JUST HEALTH INFORMATION. IT’S A REVOLUTION IN HEALTH INFORMATION SHARING.

MEET OUR SPONSOR Children’s Connect is made possible with the generous support of PNC. Like Children’s, PNC is committed to helping kids live well and achieve great things. Our friends at PNC have pledged to sponsor the initiative for its first five years.

Heather Ambrose, DNP, RN, CPON, CPN IMAGINE WATCHING A VIDEO THAT PUTS YOUR MIND AT EASE ABOUT YOUR CHILD’S CHRONIC CONDITION. IMAGINE PLAYING A GAME WHILE YOU’RE WAITING TO HAVE A TEST. IMAGINE GETTING DISCHARGE ORDERS DELIVERED TO YOUR SMART PHONE.

That day is coming, thanks to Children’s “This is an opportunity to provide better Children’s Connect is expected to greatly Connect. Our new patient engagement tool education for our patient populations, and impact and increase patient satisfaction, is revolutionizing the way Children’s Hospital to make education more dynamic and and deliver a whole new level of comfort of Pittsburgh of UPMC communicates with user-friendly. Hopefully, it will lead to greater and support. patient families. understanding from the parent perspective,” Ms. Ambrose said. Ms. Ambrose said, “I think it will improve Virtually every area of the hospital will be fair patient satisfaction regarding the discharge game for learning — including the Emergency For patients in outpatient settings, Children’s process and how well the families feel prepared Department, waiting areas, inpatient rooms, Connect will not only educate, it will serve as a to go home with their child.” exam rooms, and physician offices. Life- welcome distraction. During waiting periods, changing content will live on hospital TVs children will be able to play a game or watch a Children’s Connect is a two-year, five-phase and tablets and will be accessible from any movie to pass the time. project. Now in the Pilot Phase, it’s being personal device. tested in Surgery, Hematology/Oncology, the For inpatients, the platform will also be used Emergency Department, Observation Unit, and “In today’s world, people want information to entertain, but more importantly, to teach. outpatient waiting areas. It should expand to on their phones and tablets. They want to Patients and families will follow a whole new Children’s regional locations by mid-2017. access it multiple times. So part of the goal set of doctors’ and nurses’ orders: by watching of Children’s Connect is to make patient videos. And once they’ve tuned in, it will be Thousands of parents and children can’t wait education more readily accessible and documented in the electronic medical record. to connect. available,” said Heather Ambrose, DNP, RN, CPON, CPN, director of Nursing. THE PERFECT RECIPE FOR

HOPEIN BONE MARROW TRANSPLANT

A CULTURE OF CARING The Division of Blood and Marrow Transplantation and Cellular Therapies is just one of many hospital programs helped by Children’s employee giving campaigns. In FY15, more than one-third of Children’s staff and physicians gave personally to benefit research like this. In all, Children’s employees gave over $500,000.

Paul Szabolcs, MD WHEN 22-YEAR-OLD ZACHARY BEWLEY, FOUND OUT HE HAD A DORMANT FORM OF METACHROMATIC LEUKODYSTROPHY OR MLD, THE SAME DISEASE THAT CLAIMED THE LIFE OF HIS BROTHER, HE WAS FACED WITH A CHOICE.

(Left) Poster and cards Zach received during his BMT, 2014; (right) Zach’s friend Jenn dedicated part of her Bikes for Tikes ride to Zach, 2015

“Do I let my life play out and take the risk of the with malignant diseases like blood cancers Next, they recruited 40 patients with more disease activating, or do I use this opportunity and lymphomas, they destroy existing bone than 20 different diseases, all treatable with presented to me?” Zachary asked himself. He marrow cells to make way for donor cells, either bone marrow replacement. “Actually one of knew the risks. And he knew what he had to do. bone marrow or cord blood. These regimens the strengths of the regimen is its effectiveness “I know Nate would have taken the opportunity can be lifesaving, but they have a high in treating as many as 14 diseases,” said Dr. as well if it had been caught in time.” mortality rate, and are avoided entirely Szabolcs. Zachary Bewley was among the in patients deemed too fragile. participants. The opportunity Zachary had was a bone marrow transplant. It had the potential to Dr. Szabolcs set out to investigate if the Their results confirmed their hopes. Mortality cure his disease, but the risk of this lifesaving intensity of chemotherapy used to fight decreased almost three-fold, from 15 to 20 treatment could be life-threatening itself. malignant diseases could be reduced for percent mortality down to 5 to 7 percent. And Fortunately, a study was underway at Children’s patients with non-malignant diseases, patients patients suffered far fewer health problems that could make his treatment less risky. just like Zachary. then expected after traditional conditioning.

Paul Szabolcs, MD, chief of the Division of Many devastating diseases are non-malignant Zachary is back to his old self. “With the support Blood and Marrow Transplantation and Cellular — diseases of the immune system, congenital of my family pushing me, and by taking it one Therapies, was investigating a safer approach errors of metabolism — life-threatening step at a time, my endurance is back to where it for bone marrow transplantation for patients diseases that are potentially curable through used to be, if not better. Every day I think about with non-malignant diseases. bone marrow and cord blood transplant. how blessed and how fortunate I am to be able to be doing all of these activities again.” “The traditional regimens for myeloablative He designed a new regimen with careful conditioning were determined in the 1970s consideration. “We looked at earlier trials. It Dr. Szabolcs says the study “could have a huge and ‘80s,” said Dr. Szabolcs. was helpful to see other results even in trials impact. Imagine a therapy where you get the where the results were not encouraging,” same results or better, with less suffering, less These “conditioning” regimens, which can said Dr. Szabolcs. “It’s a delicate balance; risk of dying, and a higher quality of life.” include chemotherapy and total body you’re choosing between shades of grey.” radiation, are what make bone marrow The new regimen relied on lower doses of transplants possible. Designed for patients chemotherapy and no radiation. UNRAVELING THE IMPACT OF HEART DEFECTS ON BRAIN DEVELOPMENT

In the spring of 2016, Drs. Panigrahy and Lo were awarded a $2 million grant from the U.S. Department of Defense to study brain ciliary genetic abnormalities in congenital heart disease.

Dr. Panigrahy recently received a prestigious R01 grant from the National Lung, Heart, and Blood Institute to use innovative brain connectivity techniques to study aberrant brain development in patients with hypoplastic left heart syndrome who are enrolled in the Single Ventricle Reconstruction Trial of the Pediatric Heart Network.

Cecilia Lo, PhD Ashok Panigrahy, MD SHERLOCK HOLMES WOULD HAVE MADE A GOOD MEDICAL RESEARCHER. MEDICAL RESEARCH INVOLVES DETECTIVE WORK, COLLECTING EVIDENCE, FOLLOWING CLUES, AND LINKING DATA TO FIND A SOLUTION. THE IMPACT OF HEART DEFECTS ON

Ashok Panigrahy, MD, plays with Hank Sabo as sister Lauren (left) and mom Kerani (background) look on.

Children with congenital heart disease are Dr. Lo’s cardiac research on mice showed subtle For Kerani and Caleb Sabo, whose infant fortunate to have Ashok Panigrahy, MD, abnormalities in specific areas of the brain. “We was diagnosed with hypoplastic left heart radiologist-in-chief at Children’s Hospital, on discussed these abnormalities. I looked back syndrome in utero, the study has meant peace their case. For them, advances in cardiovascular over 10 years of scans, looking specifically for of mind. “I wanted to set Hank up to have the surgery and therapies have led to longer lives. these subtle abnormalities in these key areas best chance,” says Ms. Sabo, so brain imaging Unfortunately, the quality of those lives has of the brain. There it was,” says Dr. Panigrahy. was done in utero, at birth, before and after been adversely affected by brain abnormalities. his first two surgeries, and will continue The reasons why have long been a mystery. He began to pile up evidence that would throughout his first six years. “He’s doing very indict not surgical technique, but genetics as well,” says Ms. Sabo, who has high hopes for the Dr. Panigrahy set out to solve that mystery. He the driving cause behind brain abnormalities, research, “I hope they find a way to protect the had a hunch it was the surgeries to repair the the notion being that the same genetic brain or minimize the impact of heart defects defects that led to these brain abnormalities. causes of heart defects may also perturb brain on brain development.” If he could identify what was happening in development. surgery to cause the problem, perhaps he In the short term, when the team identifies could advise changes in surgical technique Now Dr. Panigrahy and Dr. Lo have teamed abnormalities, they can refer patients like Hank to prevent it. up, recruiting patients in parallel, to study to early interventions to address behavioral the brain throughout the first 10 years of life. and cognitive issues. In the long term, they But as so often happens in detective work, Through advanced brain imaging they are hope to unlock the mechanism driving these the first suspect isn’t always guilty. learning many different factors are involved. abnormalities and focus strategies “What compounds the issue is not surgery, for treatment. The breakthrough came when a basic but developmental events occurring in the science researcher, Cecilia Lo, PhD, chair of prenatal period. Additional stressors, like the Someday, Dr. Panigrahy imagines, “All kids Developmental Biology at the University of ICU and post-operative period, play a role. Also with congenital heart disease will have normal Pittsburgh, shared research findings on the important is the influence of socioeconomic cognitive development throughout their lives. genetic factors underlying heart disease, factors, the family, and parenting skills.” Not only will we fix their heart, but their brains published in Nature last year. Dr. Panigrahy will develop as normally as any other child.” spotted a clue. CAN GENE THERAPY

CUREDIABETES?

IT TAKES A VILLAGE Children’s groundbreaking research would not be possible without the generous support of our community. In 1997, an anonymous donor family established the Cochrane-Weber Endowed Fund in Diabetes Research. Each year, the fund’s committee, which includes members of the donor family, ranks proposals and awards approximately $100,000 in grants toward research projects at Children’s benefitting children with diabetes. Through this fund, several junior investigators in Dr. Gittes’ lab have been able to apply their time and talent to this important work.

George Gittes, MD ROBIN DEHAVEN UNDERSTANDS JUST HOW IMPORTANT INSULIN IS. SHE’S AN EXPERT AT MONITORING BLOOD GLUCOSE, AND SHE KNOWS HOW CARBOHYDRATES AND EXERCISE CAN AFFECT A1C LEVELS. ROBIN ISN’T A PHYSICIAN. SHE’S A 12-YEAR-OLD GIRL.

(Left to right) Monica, Robin, and Paul Dehaven.

At age 4, when Robin started to have insulin. Remarkably, the mice’s immune In mice the therapy requires open surgery, extreme thirst and mood changes, her systems did not destroy these but Dr. Gittes explains treatment would be parents, Monica and Paul Dehaven, knew insulin-producing cells — an outcome never noninvasive for human patients, “Fortunately something was wrong. Robin was diagnosed before seen without the use of powerful and there is a well-established non-surgical with Type 1 diabetes, a disease most doctors dangerous immunosuppressive drugs. procedure that would make this a simple believe is irreversible. One doctor isn’t so outpatient treatment.” sure. The mice were effectively cured of diabetes, and they stayed cured for four months. Whether this therapy can be translated to In a healthy body, alpha cells secrete work safely in humans remains to be seen, glucagon and beta cells secrete insulin, “We were very excited about the results,” says but Dr. Gittes is optimistic and eager to begin hormones that together keep blood sugar in Dr. Gittes, “because four months in a mouse human trials. “I can imagine a future where balance. But for Robin, and millions of other model can translate into 10 to 20 years in the effects of diabetes can be mitigated or people with Type 1 diabetes, the body’s human metabolism.” eliminated through gene therapy.” own immune system destroys the insulin- producing beta cells. Now, Dr. Gittes and his team are working This is a future millions of people around the to translate these findings into a treatment world would love to see, including Robin and George Gittes, MD, surgeon-in-chief at for humans. her parents. “We’ve talked about what we’d Children’s, is leading research into a gene do if a cure ever becomes available,” says Paul therapy that would enable the alpha cells to Dehaven, “We’d invite all of her friends and “For Type 1 diabetes, this could be the holy produce insulin instead of glucagon. have an ice cream party.” grail,” says Dr. Gittes. Patients with Type 2 diabetes also would benefit from the Dr. Gittes and his team used a doctored treatment since many suffer from pancreas It’s hard to imagine a sweeter ending than virus to shuttle DNA into the pancreas of “burnout” where the overworked pancreas that. diabetic mice — altering the genetic profile stops producing insulin. of the alpha cells to instruct them to produce

A big, resounding thank you to our community — the community that established and has supported Children’s Hospital for 125 years.

Back in 1890, young Kirk LeMoyne endowed one single cot in an adult hospital to be used for a child. His act sparked the Pittsburgh community to come together to eventually establish the region’s only children’s hospital. Pittsburgh Hospital for Children admitted its first patient on June 4, 1890. In the more than 125 years since, community members like you have continued to invest in this special institution.

Today, community support goes well beyond funding cots...it purchases state-of-the-art research equipment, funds programs that otherwise wouldn’t exist, and pays for positions that would go unfilled.

You do this through your generosity, and we celebrate your efforts.

In total, more than $22 million was raised during the 125th anniversary year to support Children’s Hospital of Pittsburgh of UPMC. Thank you for doing your part to make 125 years of caring possible for our kids and their families!

A milestone anniversary such as ours deserves a proper celebration, so we celebrated our 125th with you for a full year! Here’s a recap, inside:

125 Years of Caring was generously sponsored by 125TH ANNIVERSARY KICK-OFF EVENT AND GIVING BOOTH DEBUT JUNE 4, 2015

Held for patients, families, staff, volunteers, and community leaders in the hospital’s Eat’n Park Atrium, the event included government leaders including State Senator Jay Costa, State Senator Wayne Fontana, Allegheny County Executive Rich Fitzgerald, and Pittsburgh Mayor Bill Peduto. Musicians, jugglers, and other entertainers roamed the floors of the hospital, entertaining kids and families in waiting areas.

Children’s Giving Booth made its debut this same day. Over the anniversary year, the mobile, interactive story kiosk traveled to events throughout the region, and members of the community had an opportunity to share their Children’s Hospital memories or memories from their own childhood. Over the year, more than 400 kids and adults shared their stories through the Giving Booth, which you can still view at givetochildrens.org. IT’S ABOUT TIME! BLACK-TIE GALA OCTOBER 2, 2015

The 125th Anniversary Gala was held at the David L. Lawrence Convention Center with more than 900 supporters in attendance, including celebrities, athletes, and business and government leaders. This celebration recognized 125 years of caring by our community and the hundreds of thousands of individuals who have given their time and support to ensure that every child in this region has access to the care they need and deserve, according to Foundation President Greg Barrett.

The honorary chair for the evening was actor and Pittsburgh native, Joe Manganiello. Emcee for the gala was KDKA-TV anchor Ken Rice. Other celebrity guests included former Pittsburgh Steelers Brett Keisel and Troy Polamalu; Mario Lemieux; and Stephanie McMahon, chief brand officer, World Wrestling Entertainment Inc. (WWE).

The Gala honored Beacon of Hope recipients Eat’n Park Hospitality Group and Howard Hanna Real Estate Services, which collectively have raised nearly $20 million for the care of children. The gala’s Legacy of Hope recipient John G. Rangos Sr. is a renowned business leader and member of the Children’s Hospital of Pittsburgh Foundation Board of Trustees. He has donated more than $9.5 million to Children’s, including a significant gift in 1989 that helped to found the first Children’s Hospital research building.

Denise Pampena and Ramsey Lyons, who serve as trustees of the board of Children’s Hospital of Pittsburgh Foundation, co-chaired the event and helped make the Gala one of the most successful nights in Children’s Hospital fundraising history. PATIENT CHAMPION MEDAL CEREMONY MAY 25, 2016

This unique medal ceremony, held in the Eat’n Park Atrium, celebrated the resiliency of our patients and was hosted by retired Pittsburgh Steeler Brett Keisel.

The Patient Champion Medal Ceremony was an event held as a precursor to the Walk for Children’s, held on June 4, 2016, to culminate the anniversary year.

To honor all of our patients — and in particular those unable to walk for themselves — Keisel distributed special medals to both inpatients as well as outpatients coming in for appointments. WALK FOR CHILDREN’S JUNE 4, 2016

To close out our special 125th anniversary year, families, caregivers, corporate partners, and other community supporters participated in the inaugural Walk for Children’s held at Flagstaff Hill in Schenley Park. Once again, our community of supporters ensured this event — a first of its kind — was a resounding success. More than 2,500 walkers participated, and the walk raised more than $611,000.

The Walk kicked off with a patient champion parade, with more than 100 patients and their families and friends dressed in purple shirts and displaying medals, leading the group to the starting line.

Entertainment filled the park from 96.1 KISS FM, Blended Reality, and the Pittsburgh Steeline. Other activities included a free helmet giveaway, courtesy of Kohl’s Hard Heads Helmet Program; bounce houses; face painting; a race car display by Kennedy Motorsports; snacks from Dairy Queen and Eat’n Park, and more.

Walk co-chairs were Scott Lammie, chief financial officer, UPMC Health Plan, and Morgan O’Brien, chief executive officer, Peoples Natural Gas. Ken Rice from KDKA-TV served as the emcee.

The event was such a success that we’ve decided to make it an annual opportunity for our community to come out to support, celebrate — and walk — with us. IMAGINATIVE WAYS TO GIVE

Sharing is Caring Shootout Altoona native SARAH DONLEY organizes Preston John this ANNUAL HIGH Streiff Memorial SCHOOL GIRLS’ Golf Outing Angels Fund Soirée BASKETBALL TIPOFF DR. MARION VUJEVICH and EVENT to raise money Golfers hit the links for this his son DR. JUSTIN VUJEVICH for the Free Care Fund. INAUGURAL GOLF OUTING HONORING THE MEMORY OF organize this annual evening In FY15, fundraising of FOOD, FUN, AND SPECIAL efforts totaled PRESTON JOHN STREIFF. All GUESTS to help families with proceeds are divided between extraordinary medical need. $2,800; the Free Care Fund and the PICU. In FY15, the event raised this year’s event raised The outing raised nearly $30,000; $8,400 In FY16, the event OVER and the 2nd annual saw donations $12,000. event was held DOUBLE May 21, 2016. Bowling with Barb $60,000. To strike out mitochondrial diseases, BARB MENDLESOHN of Shawnee Mission, Kansas hosts an annual bowling event benefitting THE FISCH FAMILY FUND in support of No Shave DR. JERRY VOCKLEY’S RESEARCH. November In FY15, the event raised over In November, things get a little hairy at $18,000 In FY15, participants raised Children’s. PEDIATRIC totaling more than RESIDENTS GO WITHOUT SHAVING, securing sponsorships $93,000 OVER over the past 7 years. to raise funds for $8,000. Pennies From Heaven. IMAGINATIVE WAYS TO GIVE OUR COMMUNITY DOES NOT LACK IMAGINATION WHEN IT COMES TO FINDING INVENTIVE WAYS TO RAISE FUNDS FOR CHILDREN’S. EXPLORE A FEW OF THE MANY WAYS PEOPLE HAVE HELPED TRANSFORM YOUNG LIVES.

Layups for Lucy 8th grader GRACE BEAL ORGANIZES THIS ANNUAL BASKETBALL LAYUP EXHIBITION at Neshannock High School to honor her sister Arlen Janet runs for Lucy who passed away from congenital heart Team Children’s disease in 2009. In 2014, the event raised ARLEN JANET of Leesburg, Virginia runs the half marathon as an All-Star for Team Children’s. EIGHT YEARS AGO, ARLEN DONATED PART $5,850. OF HIS LIVER TO HIS DAUGHTER ALAINA In 2015, the event raised who was born with a rare liver disease. OVER In 2015, Arlen raised nearly $17,000. $11,000 for Transplant Research. Brendan Allison’s Birthday Birdies for a Cause For his EIGHTH BIRTHDAY, BRENDAN asked friends and family to make a Whenever the UPPER ST. CLAIR HIGH SCHOOL donation to Children's IN LIEU OF A GIFT. GOLF TEAM makes a birdie, they have a great reason to celebrate. EACH BIRDIE made last Brendan raised more than season raised money for the FREE CARE FUND. $2,000 In FY15, the team raised and plans to do it again for his 9th birthday. $4,444. Elliot Mast’s “For the Teresa’s Hope 4 Hearts Kids” Campaign RICH AND CHELSEA STACY established For every homerun, base hit, and an annual golf outing IN HONOR OF THEIR strikeout thrown, college baseball DAUGHTER TERESA, to help give hope player and former Children’s patient to other “heart” families. ELLIOT MAST pledges to raise additional funds “for the kids who In FY15, Teresa’s Hope 4 Hearts fund can’t play.” raised over All of Elliot’s fundraising $5,000. efforts support the Child Life department. FOUNDATION BY THE NUMBERS

FY15 Donation Totals BY AREA OF SUPPORT (FY15 was July 1, 2014 through June 30, 2015.)

Capital/Facilities $26,087

Division/Program Support $7,739,005 Research $3,423,333 Uncompensated Care $2,253,898 Unreimbursed Services $1,669,625 TOTAL Unrestricted Support $5,247,840 Uncompensated Care helps Children’s Hospital fulfill its mission of caring $20,359,788 for every child regardless of his or her family’s ability to pay.

Unreimbursed Services represents the money raised for services for patients and families that are not covered by health insurance, such as Child and Family Life, the Ronald McDonald Care Mobile, Family Care Connection Centers, the School Program, and Supportive Care.

Unrestricted Support directs funds toward the hospital’s greatest needs.

GIVING SOCIETY DONORS (July 1, 2014–June 30, 2015) LeMoyne Society Children’s Circle of Care 606 $1,000 to $9,999 annually 155 $10,000 or more annually TOTAL NUMBER 25,047 OF DONORS WE ARE GRATEFUL TO OUR COMMUNITY, ALL OF THE INDIVIDUALS, BUSINESSES, AND FOUNDATIONS WHOSE SUPPORT HAS MADE A DIFFERENCE IN CARING FOR KIDS AND FAMILIES.

FY16 Donation Totals BY AREA OF SUPPORT (FY16 was July 1, 2015 through June 30, 2016.)

Capital/Facilities $444,942 Division/Program Support $5,048,980 Research $5,919,515 Uncompensated Care $1,788,437 Unreimbursed Services $1,931,188 TOTAL Unrestricted Support $7,011,616 Uncompensated Care helps Children’s Hospital fulfill its mission of caring $22,144,678 for every child regardless of his or her family’s ability to pay.

Unreimbursed Services represents the money raised for services for patients and families that are not covered by health insurance, such as Child and Family Life, the Ronald McDonald Care Mobile, Family Care Connection Centers, the School Program, and Supportive Care.

Unrestricted Support directs funds toward the hospital’s greatest needs.

GIVING SOCIETY DONORS (July 1, 2015–June 30, 2016) LeMoyne Society Children’s Circle of Care 579 $1,000 to $9,999 annually 144 $10,000 or more annually TOTAL NUMBER 31,160 OF DONORS THROUGH YOUR GENEROSITY, WE WERE ABLE TO REINVEST RESOURCES BACK INTO OUR LOCAL COMMUNITY, PROVIDING THESE TOTAL COMMUNITY BENEFITS IN 2015.

TOTAL COMMUNITY BENEFITS FY15

Free and $20.8m Uncompensated Care Support of Scientific $10.3m Research Projects Community Benefit $10.1m Programs Support of Graduate Medical $29.7m Education Programs

FISCAL YEAR 2016 COMMUNITY BENEFITS NUMBERS WILL BE PUBLICLY REPORTED IN JANUARY 2017

STAYS, VISITS, AND PROCEDURES

Hospital and Physician Emergency and Surgical Procedures Outpatient Visits Inpatient Stays Express Care Visits FY15 23,534 1,055,033 20,725 131, 320 FY16 23,660 1,121,407 21,321 136,220

HIGHLIGHTS & FEATURES

HEART OF GOLD CAMP CELEBRATES SILVER ANNIVERSARY Imagine, children with heart conditions enjoying summer camping fun — just like any other kid. For the 25th year, that’s just what has happened at Dr. Bill Neches Heart Camp for Kids. Funded almost entirely through philanthropy, this community treasure would not be possible without the generous support of generous patient families and community members, the American Heart Association and Atria’s Restaurant.

LEADING FOOD ALLERGY CARE FORWARD In the United States,

1 in every 13 kids suffers from potentially life-threatening food allergies. Children’s is working to make sure they get the very best care. In May 2015, Food Allergy Research & Education (FARE) gave our hospital a $120,000 grant and named us a Food Allergy Center of Excellence. As a full inaugural member of the FARE Clinical Network (FCN), Children’s will help set the standard of food allergy care for kids across the nation. IN FULL SWING MARKING A MILESTONE WALK-OFF CELEBRATION University of Pittsburgh students danced IN STYLE The 125th anniversary celebration the night away for a great cause. The The signature event of the 125th ended with the beginning of University’s largest student-run Anniversary celebration, something new fundraising event, Pitt Dance Marathon the inaugural (PDM), is a yearlong effort culminating in It’s About Time, a 16-hour dance marathon. On February Children’s 125th Anniversary 21, 2015, an estimated 2,000 dancers and Celebration Gala, was held Friday, Walk for supporters came out for the event, raising October 2, 2015 at the David L. more than $153,000 for Children’s. Their Lawrence Convention Center. efforts got the ball rolling, because in May, Children’s. On June 4, 2016 Children’s Hospital American Eagle committed a generous Nearly 900 guests of Pittsburgh Foundation hosted the $300,000 grant to Children’s — a portion attended the black-tie event honoring inaugural Walk, a community-wide of which is designated to expand the Dance the corporate and community fundraiser that celebrates both the Marathon over the next three years. partners who have given generously culmination of the hospital’s milestone to Children’s throughout our 125-year 125th anniversary year, as well as CELEBRATING 125 YEARS history. the beginning of a new chapter for Children’s Hospital of Pittsburgh of UPMC. OF CARING Co-chairs: Ramsey Lyons and On June 4, 2015, Denise M. Pampena TOP 10, SEVEN YEARS STRONG Children’s Hospital Infinity Title Sponsor: For the seventh consecutive year, kicked off a yearlong PNC Bank Children’s was named to the celebration of our 125th Host Committee Chair: anniversary, Dorothy Pollon U.S. News & with the goals of raising funds for patient Corporate Leaders Chair: care and research, attracting a new World Report Howard W. Hanna III generation of support, and engaging the community. The 125th Anniversary Honorary Chair: Honor Roll campaign galvanized the community in Joe Manganiello of America’s “Best Children’s Hospitals” in 2016-17. support of Children’s Hospital of Pittsburgh Legacy of Hope Honoree: of UPMC. John G. Rangos Sr. Beacon of Hope Honorees: We ranked 7th Eat’n Park Hospitality Group, Inc. in the nation Howard Hanna Real Estate Services overall Emcee: and were rated among the Ken Rice, KDKA top 15 pediatric hospitals in Honorary Guest: Sam Cain, Children’s patient 8 of the 10 and cancer survivor specialties the magazine evaluates. “This recognition speaks to the talent, passion, and dedication of our physicians, nurses, staff, and volunteers,” said Christopher Gessner, president. HIGHLIGHTS & FEATURES

IN THE LEED What if we could provide world-class pediatric care while taking good care world?of the You’d have Children’s South. The South Fayette facility received LEED (Leadership in Energy and Environmental Design) certification from the U.S. Green Building Council (USGBC) in recognition of the building’s energy-saving features and “green” construction.

SHINE A LIGHT ON BULLYING What if we all stood together against bullying? We’d have a chance to put a stop to it for good. That’s why Children’s and 100.7 STAR joined together for Shine a Light on Bullying. This innovative program helps children and teens spot and address bullying in their schools. The Division of Adolescent and Young Adult Medicine was proud to team up with Bubba, Shelly, and the whole morning crew at 100.7 STAR. A HEART TO HEART RECORD-BREAKING BETWEEN HOSPITALS RADIOTHON BIG BEN THROWS IN In October 2014, Children’s Hospital Ben Roethlisberger called in to of Pittsburgh of UPMC announced a the thannual contribute, putting up not just partnership with St. Joseph’s Children’s 8 $5,000, but also the cleats that he Hospital in Florida to enhance pediatric DVE Rocks wore when he broke Terry Bradshaw’s heart services. Together, Children’s and St. record for starts. The QB’s cleats were Joseph’s are providing highly specialized for Children’s raffled off during a “Power Hour” that cardiovascular care for everything from helped attract 250 new donors — fetal cardiology to adult congenital Radiothon another record for Children’s. heart disease inside St. Joseph’s Heart ruled the airwaves from Institute, a new 35,000-square-foot, September 24-26, state-of-the-art facility in Tampa. The HOME IMPROVEMENT using the power of radio partnership offers the expertise of some of Pittsburgh Magazine debuted the the country’s top-ranking pediatric heart to encourage listeners to pitch in for kids. first-ever Ultimate House, a multi- specialists, based here at Children’s, to million-dollar home in Pine Township Thanks to the tireless effort ofthe families across Florida. that showcases the latest trends in home talented people at WDVE, the innovations and architectural design. support of hundreds of volunteers Children’s was chosen as the beneficiary of AT OUR MOST BEAUTIFUL and staff, and the nearly the inaugural project, with 100 percent of Children’s was named one of the most Ultimate House tour ticket sales going beautiful hospitals in the United States 4,000donors toward Children’s Free Care Fund. by Soliant Health, a leading specialty health care staffing provider and part of Along with Pittsburgh Magazine, many Adecco Group. Voting took place during other companies contributed to Ultimate a month long period. Folks who voted House fundraising, including: People’s for us might have liked our Healing who answered the call, the Natural Gas, Primrose Homes, Baierl Garden, Transformation Corridor and three-day event raised more than Automotive, Don’s Appliances — even the giant neon bugs in the Atrium. the home’s eventual owner and his employer. In total, the 2015 Ultimate

$653,000, House generated $100,000 for the A GOOD JOE a new record. Free Care Fund.

Favorite son Joe Manganiello keeps The station’s generosity did not go Pittsburgh and Children’s close to his heart. unnoticed. Children’s Miracle Network His generosity can be seen in his visits Hospitals recently announced that WDVE with patients and families, in directing has been named their 2016 English Radio wedding gifts from his marriage to Station of the Year — a national honor! Ticket sales for the 2016 Ultimate Sofia Vergara to Children’s and in The 9th annual Radiothon was held Sept. House will again benefited Children’s committing to serve as the Honorary 15–17, 2016. With this year’s event, the total Free Care Fund. The home is located at Chair of Children’s Foundation’s dollars given through Radiothon surpassed 2500 Smallman Street in the Strip District. Creative and Expressive Arts Therapy campaign. $4 million.

WELCOME ABOARD The Boards of Trustees for Children’s Hospital of Pittsburgh of UPMC and Children’s Hospital of Pittsburgh Foundation consist of talented community leaders helping to guide efforts to establish Children’s Hospital as the world leader in children’s health. In FY15–16, both boards welcomed new members who add invaluable experience, knowledge, and imagination to Children’s. Russell L. Cersosimo* Randall S. Dearth* Russell L. Cersosimo is the founder and A recognized leader both regionally and former CEO of Guardian Protection Services, internationally, Randall S. Dearth brings a the nation’s largest privately held security wealth of expertise and experience to the systems firm. Under his leadership for 30 years, Children’s Hospital of Pittsburgh Foundation the company received numerous industry Board of Trustees. Mr. Dearth serves as recognitions. In addition to his service to chairman, president, and CEO of Calgon Children’s Foundation, Mr. Cersosimo has Carbon Corporation. In addition to the Calgon previously been active in the Make-A-Wish Carbon Corporation Board of Directors, Foundation and has also served on the board Mr. Dearth also sits on the boards of the of Camp Kon-O-Kwee, a camp focused on Allegheny Conference on Community serving children and adults with disabilities Development, the Carnegie Museums of and youth from at-risk communities. Pittsburgh, and Hiram College. Lalit Chordia, PhD* Terence Dermody, MD** A world-renowned technology innovator, As a world-renowned researcher and Lalit Chordia, PhD, owns and operates four infectious disease specialist, Terence Dermody, companies in the United States and India, MD, has devoted his professional career to including Thar Energy, LLC, a global leader in the care and cure of children. Dr. Dermody green, high-pressure processing technologies is the Vira I. Heinz Professor and chair of the for the pharmaceutical, food, chemical, and Department of Pediatrics at the University of energy industries. Dr. Chordia and his wife, Pittsburgh School of Medicine and Supriya, reside in Fox Chapel. They have three physician-in-chief and scientific director at sons, Eshan, Priyansh, and Shivang. Children’s. A visionary leader in his field, Dr. Dermody brings considerable experience and Amanda Cindrich* knowledge to the Children’s Hospital board. In her current role as a project advisor with Dr. Dermody and his wife, Margot, have two Collateral Opportunities, Amanda Cindrich sons who live in Denver. The Dermodys are adds a tech-forward perspective to Children’s animal lovers and have a greyhound and a Foundation. Her management and support- quarter horse. focused role with Cindrich Consulting, LLC, has enhanced her multitasking capabilities, which Annette “Tinsy” Labrie* have served her well as a member of the Annette “Tinsy” Labrie brings a little bit Hearing Center Auxiliary since 2013. She has of sparkle and a lot of know-how to the also co-chaired the Auxiliary’s Casino Royale Children’s Hospital of Pittsburgh Foundation event for the past three years. Her two children Board of Trustees. Ms. Labrie is vice president are Jacob and Samantha, who are both young of marketing of VisitPITTSBURGH. She formerly scholars and athletes. held marketing and communications positions with the Pittsburgh Symphony Orchestra, Randall L. Crawford* Pittsburgh Penguins, Pittsburgh Spirit, and Proven leadership performance. It’s what Corinthian Broadcasting. Ms. Labrie has been Randall L. Crawford, senior vice president and a member of the Foundation’s Transplantation president of Midstream & Commercial for EQT Surgery Auxiliary since 2013 and served as Corporation, brings to Children’s Foundation. both co-chair and honorary chair for the Mr. Crawford is also EVP, COO, and a member auxiliary’s Diamonds and Denim fundraiser. of the Board of EQT Midstream Partners, LP. She serves on the boards of directors of Mr. Crawford resides in Fox Chapel. His fiancée, the Greater Pittsburgh Arts Council and Ellen R. Goodman, is a founding member of the Pittsburgh International Airport art the Children’s Foundation’s Cancer and Blood commission and is a Certified Destination Disorders Auxiliary. Marketing Executive through Destination Marketing Association International. In 2016 she chaired the events committee for Pittsburgh’s Bicentennial. She is a graduate of St. Francis University and Syracuse University.

George V. Mazariegos, MD* Andrew J. Nowalk, MD, PhD** World-renowned transplant surgeon As president of Children’s Medical Staff, George V. Mazariegos, MD, joined the Andrew J. Nowalk, MD, PhD understands what Children’s Foundation Board of Trustees, it takes to lead the best and the brightest. adding immense medical expertise to the Dr. Nowalk is an assistant professor in Foundation’s leadership. Dr. Mazariegos the Division of Infectious Diseases in the is director of the Hillman Center for Department of Pediatrics at Children’s Hospital, Pediatric Transplantation, Thomas E. Starzl and serves as a director of the Pediatric Transplantation Institute; holds the Jamie Residency Program. He also mentors medical Lee Curtis Endowed Chair in Transplantation students through his role as an advisory Surgery; and is a professor at the University of dean at the University of Pittsburgh School Pittsburgh School of Medicine. Dr. Mazariegos, of Medicine. As an accomplished researcher his wife, Rebekah, and their three children and talented medical education professional, reside in North Oakland. Dr. Nowalk brings a unique perspective to the Children’s Hospital Board of Trustees. He Gerald F. (Jerry ) MacCleary* resides in Fox Chapel with his wife, Amy, an The expertise at the helm of a world-leading attorney with Dickie, McCamey & Chilcote, and material provider is now at the disposal of sons Max, James, and Peter. Children’s Foundation. Jerry MacCleary is president of Covestro LLC (formerly Bayer C. Lance Ruttenberg* MaterialScience LLC) for North America. The Children’s Hospital of Pittsburgh Mr. MacCleary also serves on the Board of Foundation Board of Trustees is bolstered by Directors for Variety the Children’s Charity, the business acumen and extensive expertise United Way of Allegheny County, the Imani of C. Lance Ruttenberg, president and chief Christian Academy, and the Allegheny executive officer for American Textile Co. Conference on Community Development. Mr. Ruttenberg is a member of the board’s He has three children, and resides in Venetia Finance and Investment Committee. He also with his wife, Wanda. sits on the board of Shady Side Academy. Mr. Ruttenberg and his wife, Nicole, reside in Stephanie McMahon* Fox Chapel with their three daughters, Elle, The Children’s Hospital of Pittsburgh Reese, and Brooklyn. Foundation Board of Trustees is strengthened by the appointment of prominent Mark G. Schoeppner* businesswoman, professional wrestler, and Children’s Foundation’s Board of Trustees philanthropist Stephanie McMahon. added global leadership experience with Ms. McMahon is chief brand officer and the appointment of Mark G. Schoeppner, member of the Board of Directors for WWE. managing member of Quaker Capital Ms. McMahon and her husband, Paul “Triple Investments. In addition to Children’s Hospital H” Levesque personally established Connor’s of Pittsburgh Foundation, Mr. Schoeppner Cure at Children’s Foundation in 2014. serves on the board of HAS Haiti, a full-service Named in honor of Children’s patient Connor hospital in Haiti. He and his wife, Cindy, reside Michalek, the fund supports groundbreaking in Upper St. Clair with their four children, pediatric cancer research. In 2016, after raising Lucas, Kyle, Troy, and Lauren. nearly $1 million, Connor’s Cure expanded John A. Staley V* to serve leading research institutions John A. Staley V has been a staunch supporter nationally, including Children’s, through a new of Children’s since his son’s successful partnership with the V Foundation for Cancer kidney transplant in 1998. Now he adds his Research. The couple has three daughters, considerable talents to Children’s Foundation’s ages 10, 8, and 6. Board of Trustees. Mr. Staley is senior vice president of Wealth Management and Trust for Federated Investors and resides in Fox Chapel with his wife, Karen, and two children, John and Julie. Former co-chairs of the Children’s Foundation’s Transplantation Surgery Auxiliary, the Staleys continue to be steadfast advocates of Children’s.

*Denotes Children’s Hospital of Pittsburgh Foundation Board of Trustee **Denotes Children’s Hospital of Pittsburgh of UPMC Board of Trustee Children’s Hospital of Pittsburgh of UPMC Board of Trustees 2016

Howard W. Hanna III Douglas P. Dick Chair Mary Jo Dively, Esq. Christopher A. Gessner Steven G. Docimo, MD President George K. Gittes, MD Kimberly D. Moses, Esq. Lawrence N. Gumberg Secretary Arthur S. Levine, MD Nicholas J. Barcellona Treasurer Martha H. Munsch, Esq. Leslie W. Braksick, PhD Andrew J. Nowalk, MD, PhD Leslie Davis The Honorable Jill E. Rangos Ronald R. Davenport Jr. Joan Rossin Stephans Terence S. Dermody, MD Joseph C. Walton

Children’s Hospital of Pittsburgh Foundation Board of Trustees 2016

Officers Jay W. Cleveland Jr. James L. Guttman Rebecca Cost Snyder Chair Howard W. Hanna III John A. Staley V Clifford R. Rowe Jr. Sylvan M. Holzer Joan Rossin Stephans Vice Chair B. Scott Kern, Esq. Joseph C. Walton J. Gregory Barrett President Arthur S. Levine, MD Non-Voting Ex Officio Voting Ex Officio L. Douglas Lioon Amanda Cindrich Nicholas J. Barcellona Joseph P. Lohman Terence S. Dermody, MD Treasurer Ramsey Lyons Steven G. Docimo, MD Non-Voting Ex Officio Gerald F. MacCleary Christopher A. Gessner Rachel A. Petrucelli George K. Gittes, MD Secretary George V. Mazariegos, MD, FACS Non-Voting Ex Officio Stephanie McMahon Cindy Gradowski Tinsy Labrie Trustees Vanessa Opperman Morehouse Russell L. Cersosimo Martha H. Munsch, Esq. Brooke G. Mullin Lalit Chordia, PhD Denise M. Pampena Randall L. Crawford Dorothy J. Pollon, MBA, JD Ronald R. Davenport Jr. John G. Rangos Sr. Randall S. Dearth C. Lance Ruttenberg Douglas P. Dick Mark G. Schoeppner Mary Jo Dively, Esq. Steven J. Shangold Lawrence N. Gumberg Mark A. Snyder

givetochildrens.org

MC15175 KL/JO 11/2016 1.6K RR © 2016 UPMC

UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, gender identity, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.