Pathways to the Future
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Pathways THOUGHTS to the & INSIGHTS Future FROM FOUNDATION OUTSTANDING ACHIEVEMENT PRIZEWINNERS BBRFOUNDATION.ORGbbrfoundation.org 1 BOARD OF SCIENTIFIC COUNCIL DIRECTORS PRESIDENT J. Raymond DePaulo, Jr., M.D. President & CEO Herbert Pardes, M.D. Ariel Y. Deutch, Ph.D. Jeffrey Borenstein, M.D. Wayne C. Drevets, M.D. VICE PRESIDENT EMERITUS Ronald S. Duman, Ph.D. President, Scientific Council Floyd E. Bloom, M.D. Stan B. Floresco, Ph.D. Herbert Pardes, M.D. Judith M. Ford, Ph.D. Ted Abel, Ph.D. Alan Frazer, Ph.D. Anissa Abi-Dargham, M.D. Robert R. Freedman, M.D. OFFICERS Schahram Akbarian, M.D., Fred H. Gage, Ph.D. Chairman Ph.D. Aurelio Galli, Ph.D. Stephen A. Lieber Huda Akil, Ph.D. Mark S. George, M.D. Vice President Susan G. Amara, Ph.D. Elliot S. Gershon, M.D. Anne E. Abramson Stewart A. Anderson, M.D. Mark A. Geyer, Ph.D. Nancy C. Andreasen, M.D., Jay N. Giedd, M.D. Secretary John B. Hollister Ph.D. Jay A. Gingrich, M.D., Ph.D. Amy F.T. Arnsten, Ph.D. David Goldman, M.D. Treasurer Gary S. Aston-Jones, Ph.D. Frederick K. Goodwin, M.D. Arthur Radin, CPA Jay M. Baraban, M.D., Ph.D. Joshua A. Gordon, M.D., Deanna Barch, Ph.D. Ph.D. DIRECTORS Jack D. Barchas, M.D. Elizabeth Gould, Ph.D. Carol Atkinson Samuel H. Barondes, M.D. Anthony A. Grace, Ph.D. Eric F. Bam Francine M. Benes, M.D., Paul Greengard, Ph.D. Donald M. Boardman Ph.D. Raquel Gur, M.D., Ph.D. J. Anthony Boeckh Karen F. Berman, M.D. Suzanne N. Haber, Ph.D. Susan Lasker Brody Wade H. Berrettini, M.D., Philip D. Harvey, Ph.D. Paul T. Burke Ph.D. Stephan Heckers, M.D. Suzanne Golden Bonnie D. Hammerschlag Randy D. Blakely, Ph.D. René Hen, Ph.D. John Kennedy Harrison II Pierre Blier, M.D., Ph.D. Fritz A. Henn, M.D., Ph.D. Carole H. Mallement Hilary Blumberg, M.D. Takao Hensch, Ph.D. Milton Maltz Robert W. Buchanan, M.D. Robert M.A. Hirschfeld, M.D. Marc R. Rappaport Peter F. Buckley, M.D. L. Elliot Hong, M.D. Virginia M. Silver William E. Bunney, Jr., M.D. Steven E. Hyman, M.D. Kenneth H. Sonnenfeld, Joseph D. Buxbaum, Ph.D. Robert B. Innis, M.D., Ph.D. Ph.D., J.D. William Byerley, M.D. Jonathan A. Javitch, M.D., Barbara K. Streicker William Carlezon, Ph.D. Ph.D. Barbara Toll Marc G. Caron, Ph.D. Daniel C. Javitt, M.D., Ph.D. Robert Weisman, Esq. William T. Carpenter, Jr., M.D. Dilip Jeste, M.D. Cameron S. Carter, M.D. Lewis L. Judd, M.D. PUBLICATION CREDITS BJ Casey, Ph.D. Ned Kalin, M.D. Editors Bruce M. Cohen, M.D., Ph.D. Peter W. Kalivas, Ph.D. Lauren Duran Jonathan D. Cohen, M.D., Eric R. Kandel, M.D. Peter Tarr Ph.D. Richard S.E. Keefe, Ph.D. Designer Peter Jeffrey Conn, Ph.D. Samuel J. Keith, M.D. Jenny Reed Edwin Cook, M.D. Martin B. Keller, M.D. Richard Coppola, DSc John R. Kelsoe, M.D. Rui Costa, Ph.D., HHMI Kenneth S. Kendler, M.D. Joseph T. Coyle, M.D. James L. Kennedy, M.D. Jacqueline N. Crawley, Ph.D. Robert M. Kessler, M.D. John G. Csernansky, M.D. Kenneth K. Kidd, Ph.D. Karl Deisseroth, M.D., Ph.D. Mary-Claire King, Ph.D. JULY 2017 2 168 Members (4 Emeritus) 2 Nobel Prize Winners 4 Former Directors of the National Institute of Mental Health as well as the current Director 4 Recipients of the National Medal of Science 13 Members of the National Academy of Sciences 26 Chairs of Psychiatry & Neuroscience Departments at Leading Medical Institutions 55 Members of the National Academy of Medicine Rachel G. Klein, Ph.D. Patricio O’Donnell, M.D., J. David Sweatt, Ph.D. John H. Krystal, M.D. Ph.D. John A. Talbott, M.D. Amanda Law, Ph.D. Dost Ongur, M.D., Ph.D. Carol A. Tamminga, M.D. James F. Leckman, M.D. Steven M. Paul, M.D. Laurence H. Tecott, M.D., Francis S. Lee, M.D., Ph.D. Godfrey D. Pearlson, Ph.D. Ellen Leibenluft, M.D. MBBS, M.D. Ming T. Tsuang, M.D., Robert H. Lenox, M.D. Mary L. Phillips, M.D. Ph.D., DSc Pat Levitt, Ph.D. Marina Piciotto, Ph.D. Kay M.Tye, Ph.D. David A. Lewis, M.D. Daniel S. Pine, M.D. Leslie G. Ungerleider, Ph.D. Jeffrey A. Lieberman, M.D. Robert M. Post, M.D. Rita J. Valentino, Ph.D. Irwin Lucki, Ph.D. James B. Potash, M.D., M.P.H. Jim van Os, M.D., Ph.D., Gary Lynch, Ph.D. Steven G. Potkin, M.D. MRCPsych Robert C. Malenka, M.D., Pasko Rakic, M.D., Ph.D. Susan Voglmaier, M.D., Ph.D. Ph.D. Judith L. Rapoport, M.D. Nora D. Volkow, M.D. Anil K. Malhotra, M.D. Perry F. Renshaw, M.D., Mark von Zastrow, M.D., Husseini K. Manji, M.D., Ph.D., M.B.A. Ph.D. FRCPC Kerry J. Ressler, M.D., Ph.D. Karen Dineen Wagner, J. John Mann, M.D. Carolyn B. Robinowitz, M.D. M.D., Ph.D. John S. March, M.D., M.P.H. Bryan L. Roth, M.D., Ph.D. Daniel R. Weinberger, M.D. Daniel Mathalon, Ph.D., M.D. John L.R. Rubenstein, Myrna M. Weissman, Ph.D. Helen S. Mayberg, M.D. M.D., Ph.D. Marina Wolf, Ph.D. Robert W. McCarley, M.D. Bernardo Sabatini, M.D., Jared W. Young, Ph.D. Bruce S. McEwen, Ph.D. Ph.D. L. Trevor Young, M.D., Ph.D. Ronald D.G. McKay, Ph.D. Gerard Sanacora, M.D., Ph.D. Jon-Kar Zubieta, M.D., Ph.D. James H. Meador-Woodruff, Akira Sawa, M.D., Ph.D. M.D. Alan F. Schatzberg, M.D. MEMBERS EMERITUS Herbert Y. Meltzer, M.D. Nina R. Schooler, Ph.D. George K. Aghajanian, M.D. Kathleen Merikangas, Ph.D. Robert Schwarcz, Ph.D. Dennis S. Charney, M.D. Richard J. Miller, Ph.D. Philip Seeman, M.D., Ph.D. Jan A. Fawcett, M.D. Karoly Mirnics, M.D., Ph.D. Yvette I. Sheline, M.D. Bita Moghaddam, Ph.D. Pamela Sklar, M.D., Ph.D. Dennis L. Murphy, M.D. Solomon H. Snyder, M.D., DSc, D.Phil. Charles B. Nemeroff, M.D., (Hon. Causa) Ph.D. Matthew State, M.D. Eric J. Nestler, M.D., Ph.D. Murray Stein, M.D., M.P.H. Andrew A. Nierenberg, M.D. John S. Strauss, M.D. bbrfoundation.org 3 LETTER FROM THE PRESIDENT As we celebrate our 30th anniversary, we are excited to share the thoughts and insights of our Outstanding Achievement Prizewinners. Together, they provide a rare glimpse into the future – visionary statements of men and women who are leaders in their respective specialties. Their assessments of where we are and where we are headed are comprehensive in scope. There is universal acknowledgement of how far brain and behavior research has come since the Foundation’s inception, and excitement about recent technological advances that have made possible experiments that would have seemed like science fiction 30 years ago. However, there is recognition of how much remains to be learned about the brain’s workings. The significant impact of the Foundation is only possible through the collaboration between scientists and our generous donors, who understand that investing in brain and behavior research will continue to bring better treatment and ultimately cures and methods of prevention. We are deeply appreciative of this collaboration. Jeffrey Borenstein, M.D. President & CEO 4 The Brain & Behavior Research Foundation Outstanding Achievement Prizes These top prizes in psychiatric and neuroscience research recognize leading scientists for their innovation and productivity, and for achieving breakthrough discoveries that are bringing us closer to our goal of conquering mental illness. These prizes not only recognize and award extraordinary leadership in key fields of psychiatric research; they provide models of accomplishment for younger scientists involved in brain and behavior studies. The Outstanding Achievement Prizewinners are dedicated teachers and scientists who represent models of accomplishment for younger scientists in brain and behavior research. Lieber Prize for Schizophrenia Research Established in 1987 by Constance E. Lieber, Foundation President Emerita, and her husband, Stephen A. Lieber, Chairman of the Foundation’s Board of Directors, to bring public recognition to the outstanding discoveries being made in schizophrenia research. Colvin Prize for Mood Disorders Research Established in 1993, this prize was formerly known under the successive titles of the Selo Prize, Falcone Prize and Bipolar Mood Disorder Prize. The prize was renamed in 2012 in honor of the late Oliver D. Colvin, Jr., a great benefactor of the Foundation who left the largest single contribution in the Foundation’s history. Ruane Prize for Childhood & Adolescent Psychiatric Research This prize was initiated in 2000 by philanthropists Joy and William Ruane to recog- nize important advances in understanding and treatment of early-onset brain and behavior disorders. Goldman-Rakic Prize for Cognitive Neuroscience This prize was created by Constance and Stephen Lieber in memory of Patricia Goldman-Rakic, Ph.D., a distinguished neuroscientist renowned for discoveries about the brain’s frontal lobe, after her tragic death in an automobile accident in 2003. Maltz Prize for Innovative & Promising Schizophrenia Research Established in 2005, the prize was renamed in 2016 in honor of Board Members Milton and Tamar Maltz. The Maltz Prize is given to an investigator who has under- taken innovative and promising research in schizophrenia.