ASBMB FELLOWS Planning a Scientific Conference? the ASBMB Is Here to Help
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation
The Journal of Neuroscience, September 15, 1997, 17(18):6952–6960 Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation Lisa Cseh Edsall, Grisha G. Pirianov, and Sarah Spiegel Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007 Sphingolipid metabolites, such as ceramide and sphingosine- elicited by suboptimal doses of NGF. Moreover, SPP also pro- 1-phosphate (SPP), are emerging as a new class of second tected PC12 cells from apoptosis induced by serum with- messengers involved in cellular proliferation, differentiation, and drawal. To further substantiate a role for SPP in the cytopro- apoptosis. Nerve growth factor (NGF), a neurotrophic factor for tective actions of NGF, we found that N,N-dimethylsphingosine, pheochromocytoma PC12 cells, induced a biphasic increase in a competitive inhibitor of sphingosine kinase, also induced the activity of sphingosine kinase, the enzyme that catalyzes apoptosis and interfered with the survival effect of NGF. These the formation of SPP. This activation was blocked by K252a, an effects were counteracted by exogenous SPP. Moreover, other inhibitor of tyrosine kinase A (trkA). A rapid 1.7-fold increase structurally related compounds, such as dihydrosphingosine was followed by a marked prolonged increase reaching a max- 1-phosphate and lysophosphatidic acid, had no significant pro- imum of fourfold to fivefold stimulation with a concomitant tective effects. Our results suggest that activation of sphin- increase in SPP levels and a corresponding decrease in endog- gosine kinase and subsequent formation of SPP may play an enous sphingosine levels. Levels of ceramide, the precursor of important role in the differentiation and survival effects induced sphingosine, were only slightly decreased by NGF in serum- by NGF. -
Shigekazu Nagata Is Better Known for His Work on Apoptosis
© 2001 Nature Publishing Group http://medicine.nature.com NEWS Having originally researched the activities of the potent hematopeotic stimulator of bone-marrow cells, granulocyte colony stimulating factor, Shigekazu Nagata is better known for his work on apoptosis. Here, one of Japan’s most renowned biomedical scientists outlines the path that has taken him full circle: from stimulating cells to grow, to finding out how they die, to tying the two processes together. Shigekazu Nagata For a man who spends most of his time clusively activated in apoptosis. He says Charles Weissmann. He took the job be- thinking about death, Shigekazu Nagata is there are several questions left to be an- cause at that time, “almost no one was remarkably upbeat. For over a decade, he swered concerning the Fas pathway. using recombinant DNA technology in has been making a name for himself with Central among them is, how does the onco- Japan.” He credits his experience in research on apoptosis, the mechanism of gene product Bcl-2 block apoptosis? Weissman’s lab with forming the basis for programmed cell death, and during that However, he has no personal plans to work his future studies and teaching him an “or- time he has watched the field come alive. on an answer to that question, perhaps be- derliness and logical procedure” to re- “Medline publications on apoptosis have cause he has become a victim of his own search. In 1982, he returned to IMS for a risen from only a couple of hundred in success at propagating interest in cell death. short time before moving to the OBI in 1990 to over 10,000 this year,” he says with “There are so many other 1987 and then to taking up a satisfied nod. -
Fringe Season 1 Transcripts
PROLOGUE Flight 627 - A Contagious Event (Glatterflug Airlines Flight 627 is enroute from Hamburg, Germany to Boston, Massachusetts) ANNOUNCEMENT: ... ist eingeschaltet. Befestigen sie bitte ihre Sicherheitsgürtel. ANNOUNCEMENT: The Captain has turned on the fasten seat-belts sign. Please make sure your seatbelts are securely fastened. GERMAN WOMAN: Ich möchte sehen wie der Film weitergeht. (I would like to see the film continue) MAN FROM DENVER: I don't speak German. I'm from Denver. GERMAN WOMAN: Dies ist mein erster Flug. (this is my first flight) MAN FROM DENVER: I'm from Denver. ANNOUNCEMENT: Wir durchfliegen jetzt starke Turbulenzen. Nehmen sie bitte ihre Plätze ein. (we are flying through strong turbulence. please return to your seats) INDIAN MAN: Hey, friend. It's just an electrical storm. MORGAN STEIG: I understand. INDIAN MAN: Here. Gum? MORGAN STEIG: No, thank you. FLIGHT ATTENDANT: Mein Herr, sie müssen sich hinsetzen! (sir, you must sit down) Beruhigen sie sich! (calm down!) Beruhigen sie sich! (calm down!) Entschuldigen sie bitte! Gehen sie zu ihrem Sitz zurück! [please, go back to your seat!] FLIGHT ATTENDANT: (on phone) Kapitän! Wir haben eine Notsituation! (Captain, we have a difficult situation!) PILOT: ... gibt eine Not-... (... if necessary...) Sprechen sie mit mir! (talk to me) Was zum Teufel passiert! (what the hell is going on?) Beruhigen ... (...calm down...) Warum antworten sie mir nicht! (why don't you answer me?) Reden sie mit mir! (talk to me) ACT I Turnpike Motel - A Romantic Interlude OLIVIA: Oh my god! JOHN: What? OLIVIA: This bed is loud. JOHN: You think? OLIVIA: We can't keep doing this. -
A Sublethal ATP11A Mutation Associated with Neurological Deterioration Causes Aberrant Phosphatidylcholine Flipping in Plasma Membranes
A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes Katsumori Segawa, … , Shigeo Kure, Shigekazu Nagata J Clin Invest. 2021. https://doi.org/10.1172/JCI148005. Research In-Press Preview Cell biology Metabolism Graphical abstract Find the latest version: https://jci.me/148005/pdf A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes Katsumori Segawa,1,16,17 Atsuo Kikuchi,2,16 Tomoyasu Noji,3 Yuki Sugiura,4 Keita Hiraga,3 Chigure Suzuki,5,6 Kazuhiro Haginoya,7,8 Yasuko Kobayashi,7,9 Mitsuhiro Matsunaga,1 Yuki Ochiai,1 Kyoko Yamada,1 Takuo Nishimura,1,18 Shinya Iwasawa,2 Wataru Shoji,10 Fuminori Sugihara,11 Kohei Nishino,12 Hidetaka Kosako,12 Masahito Ikawa,13 Yasuo Uchiyama,5,6 Makoto Suematsu,4 Hiroshi Ishikita,3 Shigeo Kure,2,14 Shigekazu Nagata1, 15* 1Laboratory of Biochemistry & Immunology, World Premier International Research Center, Immunology Frontier Research Center, 11Central Instrumentation Laboratory, Research Institute for Microbial Diseases, 13Department of Experimental Genome Research, Research Institute for Microbial Diseases, 15Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan. 2Department of Pediatrics, Tohoku University School of Medicine, 10Frontier Research Institute for Interdisciplinary Sciences, and 14Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. 3Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan. 4Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan. 5Department of Cellular and Molecular Pharmacology, and 6Department of Cellular and Neuropathology, Juntendo University Graduate School of Medicine, Tokyo, Japan. 7Department of Pediatric Neurology, Takuto Rehabilitation Center for Children, Sendai, Miyagi, Japan. -
Dressing in American Telefantasy
Volume 5, Issue 2 September 2012 Stripping the Body in Contemporary Popular Media: the value of (un)dressing in American Telefantasy MANJREE KHAJANCHI, Independent Researcher ABSTRACT Research perspectives on identity and the relationship between dress and body have been frequently studied in recent years (Eicher and Roach-Higgins, 1992; Roach-Higgins and Eicher, 1992; Entwistle, 2003; Svendsen, 2006). This paper will make use of specific and detailed examples from the television programmes Once Upon a Time (2011- ), Falling Skies (2011- ), Fringe (2008- ) and Game of Thrones (2011- ) to discover the importance of dressing and accessorizing characters to create humanistic identities in Science Fiction and Fantastical universes. These shows are prime case studies of how the literal dressing and undressing of the body, as well as the aesthetic creation of television worlds (using dress as metaphor), influence perceptions of personhood within popular media programming. These four shows will be used to examine three themes in this paper: (1) dress and identity, (2) body and world transformations, and (3) (non-)humanness. The methodological framework of this article draws upon existing academic literature on dress and society, combined with textual analysis of the aforementioned Telefantasy shows, focussing primarily on the three themes previously mentioned. This article reveals the role transformations of the body and/or the world play in American Telefantasy, and also investigates how human and near-human characters and settings are fashioned. This will invariably raise questions about what it means to be human, what constitutes belonging to society, and the connection that dress has to both of these concepts. KEYWORDS Aesthetics, Body, Dress, Falling Skies, Fringe, Game of Thrones, Identity, Once Upon a Time, Telefantasy. -
It Began in 1897 As a Simple System for Holding Exams Without Proctors
The Myth of Martyrdom Good For Business Indie Innovator Challenging the conventional thinking Educating the next generation Putting the independence back about suicide bombers of executives and entrepreneurs into independent film The Magazine of Haverford College WINTER 2013 It began in 1897 as a simple system for holding exams without proctors. Since then, the cherished HONOR CODE has become the purest expression of the College’s values and an intrinsic part of a Haverford education. 9 20 Editor Contributing Writers DEPARTMENTS Eils Lotozo Charles Curtis ’04 Prarthana Jayaram ’10 Associate Editor Lini S. Kadaba 2 View from Founders Rebecca Raber Michelle Martinez 4 Letters to the Editor Graphic Design Alison Rooney Tracey Diehl, Louisa Shepard 6 Main Lines Justin Warner ’93 Eye D Communications 15 Faculty Profile Assistant Vice President for Contributing Photographers College Communications Thom Carroll 20 Mixed Media Chris Mills ’82 Dan Z. Johnson Brad Larrison 25 Ford Games Vice President for Josh Morgan 48 Roads Taken and Not Taken Institutional Advancement Michael Paras Michael Kiefer Josh Rasmussen 49 Giving Back/Notes From Zachary Riggins the Alumni Association 54 Class News 65 Then and Now On the cover: Photo by Thom Carroll Back cover photo: Courtesy of Haverford College Archives The Best of Both Worlds! Haverford magazine is now available in a digital edition. It preserves the look and page-flipping readability of the print edition while letting you search names and keywords, share pages of the magazine via email or social networks, as well as print to your personal computer. CHECK IT OUT AT haverford.edu/news/magazine.php Haverford magazine is printed on recycled paper that contains 30% post-consumer waste fiber. -
General Report on 8Th IDS
General Report on 8th IDS I) Local Organizing Committee Toshiaki Hanafusa (President, First Department of Internal Medicine, Osaka Medical College) Tetsuro Kobayashi (Vice President, Third Department of Internal Medicine, Yamanashi University) Hiroshi Ikegami (Osaka University) Akihisa Imagawa (Osaka Medical College) Yasuko Uchigata (Tokyo Women’s Medical University) Eiji Kawasaki (Nagasaki University) Kaichi Kida (Ehime University) Akira Shimada (Keio University) Kazuma Takahashi (Tohoku University) Masao Nagata (Kobe University) Eiichi Makino (Ehime University) Taro Maruyama (Saitama Social Insurance Hospital) II) Overseas Speakers GS. Eisenbarth (Barbara Davis Center UCHSC, USA) E. Gale (Southmead Hospital, Bristol, UK) DM. Harlan (National Institutes of Health, USA) LC. Harrison (The Walter and Eliza Hall Institute of Medical Research, Australia) YS. Park (Hanyang University, Korea) BO. Roep (Leiden University Medical Center, the Netherlands) L. Chatenoud (Paris, France) III) Local Speakers Tadatsugu Taniguchi (Tokyo University) Shigekazu Nagata (Osaka University) Shimon Sakaguchi (Kyoto University) Jun-ichi Miyazaki (Osaka University) Shizuo Akira (Osaka University) IV) Number of Participants 75 from Japan 145 from Overseas (12 accompanying persons) 1 IDS-8 participants list Accom. Country Subtotal Member Non-Member Person Australia 9 6 3 Belgium 1 0 1 Brazil 1 0 1 Canada 4 3 1 1 Denmark 2 1 1 Finland 21 13 8 France 2 2 0 Germany 3 3 0 India 1 0 1 Israel 1 1 0 1 Italy 2 1 1 1 Japan 75 46 29 3 Korea 9 2 7 New Zealand 2 2 0 Norway 2 2 0 1 Spain 2 1 1 Sweden 17 11 6 1 The Czech Republic 2 2 0 The Netherlands 4 3 1 U.K. -
FRINGE (September 2008 – January 2013) 5 Seasons, 100 Episodes
FRINGE (September 2008 – January 2013) 5 Seasons, 100 Episodes 1. 1-1 09 Sep 08 Pilot 2. 1-2 16 Sep 08 The Same Old Story 3. 1-3 23 Sep 08 The Ghost Network 4. 1-4 30 Sep 08 The Arrival 5. 1-5 14 Oct 08 Power Hungry 6. 1-6 21 Oct 08 The Cure 7. 1-7 11 Nov 08 In Which We Meet Mr. Jones 8. 1-8 18 Nov 08 The Equation 9. 1-9 25 Nov 08 The Dreamscape 10. 1-10 02 Dec 08 Safe 11. 1-11 20 Jan 09 Bound 12. 1-12 27 Jan 09 The No-Brainer 13. 1-13 03 Feb 09 The Transformation 14. 1-14 10 Feb 09 Ability 15. 1-15 07 Apr 09 Inner Child 16. 1-16 14 Apr 09 Unleashed 17. 1-17 21 Apr 09 Bad Dreams 18. 1-18 28 Apr 09 Midnight 19. 1-19 05 May 09 The Road Not Taken There's More than One of 20. 1-20 12 May 09 Everything 21. 2-1 17 Sep 09 A New Day in the Old Town 22. 2-2 24 Sep 09 Night of Desirable Objects 23. 2-3 01 Oct 09 Fracture 24. 2-4 08 Oct 09 Momentum Deferred 25. 2-5 15 Oct 09 Dream Logic 26. 2-6 05 Nov 09 Earthling 27. 2-7 12 Nov 09 Of Human Action 28. 2-8 19 Nov 09 August 29. 2-9 03 Dec 09 Snakehead 30. 2-10 10 Dec 09 Grey Matters 31. -
Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associate
Cancer Cell Article Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer Jie Liang,1,3,4 Masayuki Nagahashi,1,2,4 Eugene Y. Kim,1,4 Kuzhuvelil B. Harikumar,1 Akimitsu Yamada,1,2 Wei-Ching Huang,1 Nitai C. Hait,1 Jeremy C. Allegood,1 Megan M. Price,1 Dorit Avni,1 Kazuaki Takabe,1,2 Tomasz Kordula,1 Sheldon Milstien,1 and Sarah Spiegel1,* 1Department of Biochemistry and Molecular Biology and the Massey Cancer Center 2Division of Surgical Oncology, Department of Surgery Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA 3Present address: State Key Laboratory of Cancer Biology, Xi’an, Shannxi 710032, China 4These authors contributed equally to this work *Correspondence: [email protected] http://dx.doi.org/10.1016/j.ccr.2012.11.013 SUMMARY Inflammatory bowel disease is an important risk factor for colorectal cancer. We show that sphingosine-1- phosphate (S1P) produced by upregulation of sphingosine kinase 1 (SphK1) links chronic intestinal inflam- mation to colitis-associated cancer (CAC) and both are exacerbated by deletion of Sphk2. S1P is essential for production of the multifunctional NF-kB-regulated cytokine IL-6, persistent activation of the transcription factor STAT3, and consequent upregulation of the S1P receptor, S1PR1. The prodrug FTY720 decreased SphK1 and S1PR1 expression and eliminated the NF-kB/IL-6/STAT3 amplification cascade and development of CAC, even in Sphk2À/À mice, and may be useful in treating colon cancer in individuals with ulcerative colitis. Thus, the SphK1/S1P/S1PR1 axis is at the nexus between NF-kB and STAT3 and connects chronic inflammation and CAC. -
Happy Holidays ASBMB Membersbayside Biomolecules
SUBMIT YOUR LATE BREAKING MEETING ABSTRACTS BY FEB 25 January 2009 Happy Holidays ASBMB MembersBayside Biomolecules American Society for Biochemistry and Molecular Biology Edited by Ajit Varki, University of California, San Diego, Richard D. Cummings, Emory University School of Medicine, Atlanta, Jeffrey D. Esko, University of California, San Diego, Hudson H. Freeze, Burnham Institute for Medical Research, La Jolla, Pamela Stanley, Albert Einstein College of Medicine of Yeshiva University, New York, Carolyn R. Bertozzi, University of California, Berkeley, Gerald W. Hart, Johns Hopkins University of School of Medicine, Baltimore, and Marilynn E. Etzler, University of California, Davis he sugar chains of cells—known collectively as glycans—play a variety of impressive, critical, and often Tsurprising roles in biological systems. Glycobiology is the study of the roles of glycans in the growth and development, function, and survival of an organism. Glyco-related processes, described in vivid detail in the text, have become increasingly significant in many areas of basic research as well as biomedicine and biotechnology. This new edition of Essentials of Glycobiology covers the general principles and describes the structure and biosynthesis, diversity, and function of glycans and their relevance to both normal physiologic processes and human disease. Several new chapters present significant advances that have occurred since the publication of the first edition. Three sections of note describe organismal diversity, advances in our understanding of disease states and related therapeutic applications, and the genomic view of glycobiology. “Glycomics,” analogous to genomics and proteomics, is the systematic study of all glycan structures of a given cell type or organism and paves the way for a more thorough understanding of the functions of these ubiquitous molecules. -
Enhanced and Accelerated Lymphoproliferation in Fas
Proc. Natl. Acad. Sci. USA Vol. 93, pp. 2131-2136, March 1996 Biochemistry Enhanced and accelerated lymphoproliferation in Fas-null mice MASASHI ADACHI*, SACHIKO SUEMATSUt, TAKASHI SUDA*, DAISUKE WATANABE*, HIDEHIRO FUKUYAMA*, JUN OGASAWARA*, TAKASHI TANAKAt, NOBUAKI YOSHIDAt, AND SHIGEKAZU NAGATA* *Osaka Bioscience Institute, 6-2-4 Furuedai, Suita. Osaka 565. Japan, and 'Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi, Osaka 590-0)2, Japan Communicated by Charles Weissmann, Universitat Ziurich, Zutriclh, Switzerland, November 22, 1995 (received for review Jutne 26, 1995) ABSTRACT Fas is a 45-kDa membrane protein that retrovirus-into an intron of the Fas chromosomal gene transduces an apoptotic signal. The mouse lymphoprolifera- (25-28), which results in premature termination and aberrant tion (lpr) mutation is a leaky mutation of Fas. In this study, splicing of the Fas transcript. However, a small amount of we examined lymphocyte development in Fas-null mice gen- intact Fas mRNA or protein is expressed in the thymus of lpr erated by gene targeting. The Fas-/- mice progressively mice (26, 28, 29), indicating that the lpr mutation is leaky (25). accumulated abnormal T cells (Thyll, B220+, CD4-, and Therefore, it was thought that the absence in lpr mice of altered CD8-) and developed lymphadenopathy and splenomegaly, thymic cell development was related to the leakiness of the which were much more accelerated and pronounced than mutation (29). those in lpr mice. In addition, the Fas-null mice showed To overcome this problem, we created Fas-knockout mice lymphocytosis, accompanied by lymphocytic infiltration in and found that they developed hepatomegaly in addition to the lungs and liver. -
While Karen Bass Continues to Represent Her District on by Stacy M
BBA Salutes Entertainment BET Genius Talks: New Edition Industry Giants Clarence Avant Tells All (See page D-2) and Lee Bailey (See page E-3) SEPTEMBER 17, 2015 VOL.VOL. LXXVV, LXXXI NO. NO49 • 26 $1.00 $1.00 + CA. +CA Sales. Sales Tax Tax“For Over “For Eighty Over Eighty Years YearsThe Voice The Voice of Our of CommunityOur Community Speaking Speaking for for Itself Itself” THURSDAY THURSDAY,, DECEMBER JUNE 12 29, - 18, 2017 2013 BY KIMBERLEE BUCK Staff Writer Legendary filmmaker George Lucas who intro- duced movie lovers to Star Wars and Indiana Jones along with his wife Mel- lody Hobson received ap- proval from the Los An- geles City Council for the construction of the Lucas Museum of Narrative Art (LMNA). On Tuesday, June 27 the Lucas family, Los An- geles Mayor Eric Garcetti, Supervisor Mark Ridley- Thomas, Councilmember Curren Price, City Council President Herb Wesson, and other community lead- ers, representatives, stake- holders, and local schools Supervisor Mark Ridley-Thomas gathered at City Hall to publicly announce the ap- proval. The state-of-the-art cultural institution will be fully funded by the Lucas family which is estimated E. MESIYAH MCGINNIS at over 1.2 billion dollars George Lucas (at podium) speaks at a press conference after L.A. City Council approves his 1.2 Billion dollar dona- for construction and oper- tion to build the Lucas Museum of Narrative Art in Exposition Park. (L-R) Supervisor, Mark Ridley Thomas, Councilman ating endowment with no Curren Price, Filmmaker and founder of Lucasfilm, George Lucas, L.A.