Rubus Coreanus Miquel

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Culinary Science and Hospitality Research (October 2015) Vol. 21, No. 5, pp. 160-170

Review on Anti-Cancer and Anti-Imflammatory Activity from Rubus coreanus Miquel

You-Na Song1, Heon-Ok Lee1, Geon-Min Noh2, Haeng-ran Kim2, Jeong-Sook Choe and Ae-Son Om1¶ 1¶Laboratory of Food Safety and Toxicology, Department of Food Science and Nutrition, Hanyang University, Seoul 133-791, Korea 2Functional Food and Nutrition Division, Department of Agrofood Resources, National Academy of Agricultural Science, Jeonbuk 565-851, Korea

ABSTRACT: In accordance to the increasing number of death due to cancer and side effects of chemotherapy, attention has recently focused on combined treatment of natural component and anti-tumor agent. Therefore development of safe and effective functional substances derived from natural materials is required. The emergence of various functional activities of Rubus coreanus Miquel, such as antioxidant, anticancer, anti-inflammatory, etc. is continuously increasing its consumption. To utilize the above activities, many products developed by using Rubus coreanus Miquel extracts in the areas of foods, liquors, and cosmetics and medicines. In this review, anti-cancer, anti-inflammatory activity and patents of Rubus coreanus Miquel are summarized. Further studies are needed to search for development of functional material from natural origin and various application possibility using stem, leaf and fruit of Rubus coreanus Miquel.

Keywords: Rubus coreanus Miquel, anti-cancer, anti-inflammatory, patent, review

INTRODUCTION (Park EJ et al 2002). Therefore, interest in foods which have anti-cancer effects is continuously ris- In 2014, cancer is the number one cause of death ing(Peter B, Bernard L 2008). in Korea with 28.0%, where 149 of every hundred Furthermore, the reports of the correlation be- thousand people are dying from it and the death tween chronic inflammation and cancer sparked rate from cancer is continuously increasing(Jung et continuous research on dietary intervention to de- al 2015). Approximately 80～90% cause for cancer, crease inflammation reaction and then the risk of which is mainly caused by hereditary and environ- cancer(Aggarwal BB et al 2006). Inflammation is sup- mental factors, is known as radiation, virus, pro- pressed by the mechanism in which the activity of fessional carcinogen and food, smoking, drinking, nuclear factor-KB(NF-KB)is suppressed and in turn and other lifestyle factors(Kleinsmith LJ 2008; Kim SS decreased the production of inflammation related

1998). About one third of these cancer-causing fac- factors such as nitricoxide(NO) or prostaglandin E2 tors is preventative and decreases the risk of cancer (PGE2)(Sur YJ, Na HK 2008). The mechanism of many through food containing especially phytochemicals inflammation-suppressing substances with anti-in-

¶ Corresponding Author: Ae-Son Om, Laboratory of Food Safety & Toxicology, Department of Food Science & Nutrition, College of Human Ecology, Hanyang University, Seoul 133-791, Korea, Tel. +82-10-3894-8255, Fax. +82-2-2220-1856, E-mail: aesonom@ hanyang.ac.kr Culinary Science and Hospitality Research, Volume 21, Number 5 161

flammatory effects is currently based on this theo- search, it showed that national production area in- ry(Jun YK et al 2012; Kim DH et al 2011; Lee HN et creased from 23.5 ha in 1998 to 3,368 ha in 2011 al 2011; Yoon TS et al 2010; Han JY et al 2009). and production increased greatly from 12,282 M/T Meanwhile, the most widely used cancer treat- in 2008 to 17,169 M/T in 2011. However, the reality ment is surgery, which is followed by radiation the- of the increase in consumption is usually in pro- rapy or chemotherapy to aid in cancer cell death cessed foods such as jam, beverages and alcoholic (Downs-Holmes C, Silverman P 2011). However, the beverages. Therefore, there is a need for a solution anti-cancer drugs used in chemotherapy are repor- search to apply it not only in processed foods but ted to not only killing cancer cells but healthy cells. as a naturally derived biologically active substan- They can cause side effects such as kidney toxicity, ce(Choi HS et al 2006). liver toxicity, hair loss, and loss of bone marrow This study organized the research results of R. cor- functions, etc(Links M, Lewis C 1999; Lewis C 1994). eanus’s medicinal properties, especially its anticancer Therefore, to decrease the anti-cancer drug side ef- and anti-inflammation function. Also, it is aimed to fects, a more safe and effective co-administration of be a base data for naturally derived biologically ac- natural substances is gaining attention(Xu Y et al tive substance development and application possi- 2012; Tokalov SV et al 2010; Cipk L et al 2003). bility search of R. coreanus product by analyzing ex- Rubus coreanus Miquel(R. coreanus), a type of rasp- isting patent application trend. berry, which is a member of the Rosaceae family, which has been used as medicine since the ancient Anti-cancer Activity of Rubus coreanus Miquel times and is known to have the most remedial effect Various study results of R. coreanus anti-cancer ef- in the berry family has been used medically since fects are shown in Table 1. ancient times. The flower blooms in May to June To find the prostate tumor growth inhibition ef- and in July to August, the fruit ripens into a red col- fects of R. coreanus, Baek EY et al(2009) studied to or and fully ripens into a black color. The unripen find the prostate tumor growth inhibition effects of fruit is what oriental medicine calls bokbunja(An YH, R. coreanus using prostate cancer cell strain PC-3 im- Kim YH 2007; Bae GH 2000; Jeong JS, Sin MK 1996). planted mice. All the mice were fed unripe or fully R. coreanus contains as its nutrients, carbohy- ripe fruits and their prostate tumor size significantly drates, proteins, fats and fibers(Cha HS et al 2007; decrease in both groups compared to those not fed Cho SH et al 2004). It is abundant in minerals such R. coreanus(p<0.05). Decrease in prostate tumor is as phosphorus, iron and calcium and is especially assumed to have resulted from R. coreanus activat- rich in organic acids and vitamin C. Additionally, it ing caspase-3, a main gene for cell death, leading is known to have phytochemicals, various vegetable to cell death process(Baek EY et al 2013). derived bioactive components, like anthocyanin, fla- Additionally, Kim Y et al(2012) reported that un- vonoid, tannin, quercetin and phenolic acid(Yoon I ripe R. coreanus and ethanol extracts of unripe fruit et al 2003; Kim MS et al 1997; Kim MS et al 1996; (EUR) suppresses the growth of androgen-depen- Pang KC et al 1996; Lee MW 1995; Lee YA 1995; Lee dent LNCaP cell and androgen-independent DU145 MW 1995). These substances result in R. coreanus to cell. As the result of EUR administration, the ex- have antioxidant and antibacterial effect, anticancer pression of the proliferating tumor cell markers and and anti-inflammatory effect, anaphylaxix suppre- cancer gene like proliferating cell nuclear antigen ssion effect, anti-angiogenesis effect, allergy related (PCNA) and cyclin D1 and CDK4, decreased. Its ef- illness treatment effect, hepatitis type B (HBV) sup- fects were greater in LNCaP, an androgen-depend- pression effect and other various biological activi- ent prostate cancer cell compared to androgen-in- ty(Jeon YH et al 2009; Kim S et al 2013; Park MC dependent DU145 cell. Furthermore, EUR increased et al 2007). pro-apoptotic protein(Bax) and decreased anti-apop- As biological activity of R. coreanus like these re- totic protein(Bcl-2, Bcl-xL) inducing mitochondria ceive attention, consumption has continuously in- mediated cell death. crease and according to National Statiscial Office re- Meanwhile, Choung MG, Lim JD(2012) examined 162 Review on Anti-Cancer and Anti-Imflammatory Activity from Rubus coreanus Miquel the suppressing effect of cell growth by anthocyanin results showed R. coreanus suppressed growth acti- fraction of Rubus coreanus, AFRC, in human cancer vity in AGS and Kato3 cells and induced high DNA cell strains: prostate cancer, colorectal cancer, kidney damage effects. When 100 μg/mL of buthanol fr, and renal cancer, lung cancer, and leukemia. The re- ethyl acetate fr. was treated in AGS, it showed high sults showed 50% suppression of cancer cell growth growth impediment at 77-87% and 46-60% growth in prostate cancer cell strain(LNCaP) and lung cancer impediment in Kato3. Furthermore, the result of cell strain(A549) was shown at the concentration of comet assay to observe DNA damage showed R. cor- 27.6 and 16.4 μg/mL, respectively. eanus extract treatment induced DNA damage in On the other hand, AFRC of leukemia, colorectal stomach cancer cells, especially in buthanol fr. It cancer, and kidney and renal cancer cell strains showed approximately 50% DNA damage within 1 showed cancer cell growth suppression did not oc- hour of treatment. cur at over approximately 500 μg/mL, thus conclud- In addition, Jeon YH et al(2009) studied if R. co- ing it did not have growth suppression effects. reanus ethanol and hot water extract had cancer cell Furthermore, when AFRC was processed in normal growth suppressing effect on human uterine cancer human liver cell strain 293, growth suppression was cells(HeLa) and liver cancer cells(Hep3B). In HeLa under 5%, implying high safety and stability on nor- cells, of 100, 200, 400, 600, 700 μg/assay R. coreanus mal cells. It can conclude that AFRC does not affect extract concentration, 700 μg/assay concentration normal cell growth and displays high anti-cancer ac- showed high growth suppression with over 65% tivity on specific cancer cell strains. Thus, it can be (ethanol extracts of Rubus coreanus, ERC 68.5%, hot used in combination with existing anti-cancer drugs water extract, HWE 66.4%) and Hep3B also showed to assure safety and further be used as synergist to high growth suppression with 67.2% and 65.8% in improve treatment effects. ERC and HWE, respectively. Therefore, the possibility R. coreanus extracts showed suppression effect on of R. coreanus usage as anti-cancer active natural various cancer cells other than prostate cancer. functioning material is clear. Kim HJ et al(2013) measured anti-cancer effect of Kim JH et al(2006) conducted in vivo experiment R. coreanus on breast cancer cells. When treatment with inoculating mouse with tumor cell, Sarcoma- of ethanol extracts of R. coreanus, ERC, on human 180, to induce ascites tumor and solid cancer and body breast cancer cell strain, MDA-MB-231, breast then they measured the effect of HWE of R. coreanus cancer cell activity showed significant decrease(p< on tumor cell growth suppression. The result was R. 0.05)(0, 200, 300, 400 μg/mL) in concentration de- coreanus showed greater cancer cell suppression ef- pendent manner. Also, the rate of cell death in- fect than dong qual(Korean angelica root). Further- creased in concentration dependent manner by sta- more, when water extract of R. coreanus and ethanol ining both Hoechst 33322 and propidium iodide extract of R. coreanus was treated in human colon (p<0.05). Additionally, cell death related gene ex- cancer cell, HT-29, caspase-3 mediated cell death pression on mRNA and protein level, death genes, was induced and water extract of R. coreanus show- Bax and caspase-3 expression significantly increa- ed greater effects than ethanol extract of R. cor- sed(p<0.05) but anti-death gene, Bcl-2, expression eanus(Kim EJ et al 2005). significantly decreased(p<0.05). It was observed that Meanwhile, Lee KK et al(2009) confirmed metha- R. coreanus extracts not only induced decrease of nol extract of R. coreanus significantly suppressed breast cancer cell’s activity and membrane perme- (p<0.05) U937 leukemia cell growth in concentration ability but also induced cell death by controlling dependent manner(1, 10, 100 μg/mL). gene expression contributing to cell death. In study of Jeon SG et al(2007) R. coreanus ex- Anti-inflammatory Activity of Rubus coreanus Mi- tracted by methanol and each fraction(butanol fr., quel ethyl acetate fr., water fr.) administered in human Various study results of R. coreanus anti-infla- origin stomach cancer cells, AGS and Kato3 cells, to mmatory effects are summarized in Table 2. investigate growth hindrance and DNA damage. The Lee JE et al(2013) investigated inflammation re- Culinary Science and Hospitality Research, Volume 21, Number 5 163

Table 1. Anti-cancer activitiy of Rubus coreanus Miquel in experimental models

Rubus coreanus Miquel Organ Experimental cells Results Ref. (RCM) Oral dose of Nude mice Reduction in tumor growth by unripe or ripe RCM transplanted with Baek EY enhancing capase-3-mediated powder human prostate et al 2013 apoptotic process (2%, 10%(w/w)) cancer cells(PC-3) Reduction in proliferating cells by Protaste Human prostate inducing mitochondrial-mediated 50% ethanol extracts Kim Y cancer cell apoptosis of unripe fruit of RCM et al 2012 (DU145, LNCaP) (reduced Bcl-2 & Bcl-xL, increased Bax) Anthocyanin fraction Human prostate Yoon I Inhibition proliferation in cells from fruits of RCM cancer cell(LNCaP) et al 2003 50% methanol extracts of unripe fruit of RCM Human gastic Inhibition on cell growth by Jeon SG Gastric and its fraction cancer cell inducing DNA damage et al 2007 (butanol fr., ethyl- (AGS, KatoIII) acetate fr., water fr.) Inhibition on cell growth by Human breast 30% ethanol extracts inducing apoptotic genes(Bcl-2&Bax) Kim HJ Breast cancer cell of fruits of RCM and enhancing capase-3-mediated et al 2013 (MDA-MB-231) apoptotic process Aqueous and ethanol Inhibition on proliferation in cells by Human colon Kim EJ Colon extracts of unripened enhancing capase-3-mediated cancer cell(HT-29) et al 2005 fruits of RCM apoptotic process Anthocyanin fraction Human lung cancer Yoon I Lung Inhibition on proliferation in cells from fruits of RCM cell(A549) et al 2003 Ethanol and water Human uterus Jeon YH Uterus extracts of Inhibition on cell growth over 60% cancer cell(HeLa) et al 2009 fruits of RCM Ethanol and water Human liver cancer Jeon YH Liver extracts of Inhibition on cell growth over 60% cell(Hep3B) et al 2009 fruits of RCM Oral dose of Nude mice Kim JH Ascites water extracts transplanted with Inhibition on ascite tumor growth et al 2006 of fruits of RCM sarcoma-180 cells Induction of apoptosis expression Methanol gene : p53, NF B increased Human histiocytic k Lee KK Leukocyte extracts of ripened IB decreased leukemia(U937) k et al 2009 fruits of RCM protein: NFkB increased PCNA,BcL-xL decreased sponse of mice peritoneal macrophage fed with un- inflammatory response using lipopolysaccharide(LPS) ripe or fully ripe R. coreanus fruit intake. For 8 weeks, after dividing peritoneal macrophage. Secretion of R. coreanus was fed according to concentration tumor necrosis factor(TNF)-α, interleukin (IL)-1β, IL-6,

(unripe and fully ripe at 2% and 10%) and induced a proinflammatory cytokines, prostaglandin(PG)E2, 164 Review on Anti-Cancer and Anti-Imflammatory Activity from Rubus coreanus Miquel

Table 2. Anti-inflammatory activity of Rubus coreanus Miquel in experimental models

Rubus coreanus Experimental Results Ref. Miquel(RCM) material Suppression of pro-inflammatory Oral dose of LPS-stimulated mouse mediator expression Lee JE 2%, 10% fruits of RCM peritoneal macrophases Reduced TNF-α, IL-β, IL-6, PGE 2 et al 2013 (unripened, ripened) in mice Reduced gene expression (5-LOX, IL-11, NOS-2, iNOS) Inhibition of inflammatory Ethanol extracts of mediator expression LPS-stimulated fruits of RCM Reduced NO, PGE levels Yang HM RAW 264.7 murine 2 (unripened, Reduced protein levels of iNOS, COX-2 et al 2008 marcrophages half-ripened, ripened) Reduced production of cytokines (TNF-α, IL-6) LPS-stimulated Activation of the HO-1pathway Ethanol extracts of Park JH RAW 264.7 murine Reduced NO, PGE unripened fruits of RCM 2 et al 2006 marcrophages Reduced protein levels of iNOS, COX-2 Inhibition of inflammatory mediator expression Ethanol extracts of LPS-stimulated Reduced NO, PGE 2 Kim SK root and unripened RAW 264.7 murine Reduced production of cytokines et al 2013 fruits of RCM marcrophages (TNF-α, IL-1β, IL-6, IL-10) Reduced mRNA levels of iNOS, COX-2 and gene expression through cDNA microarray me- Yang HM et al(2008)’s study compared anti-in- thod was measured. The result showed unripe and flammatory effect of ethanol extracts depending on fully ripe R. coreanus intake significantly suppressed R. coreanus fruit ripening levels(unripe, medium ripe, TNF-α production(p<0.05) but IL-1β and IL-6 only de- and fully ripe). Ethanol extract of R. coreanus was creased with unripe R. coreanus and PGE2 secretion treated after inducing inflammation on RAW 264.7 was not affected by either unripe or fully ripe R. cell, a murine marcrophage, using LPS. Unripe and coreanus. Also, unripe and fully ripe R. coreanus fruit medium ripe fruits extracts significantly decreased intake markedly decreased(p<0.05) inflammatory re- nitric oxide(NO) and PGE2 production but fully ripe sponse related gene, arachidonate 5-lipoxygenase fruits did not show NO and IL-6 production sup- (5-LOX), inducible nitric oxide synthase(iNOS), IL-11, pression activity. expression. R. coreanus has difference in phenolic compound According to this data, unripe and fully ripe R. co- content according to ripening level. It is reported reanus fruit intake not only suppresses inflammatory that unripe fruit has 16 times more of cinnamic acid, response related gene expression, but also suppre- 6 times more of ferulic acid and epicatechine, 4 sses occurrence of chronic illnesses, especially car- times more of protocatechuic acid, 3 times more of diovascular related gene, ceruloplasmin, vascular en- gallic acid, and 2.5 times more of vanillic acid than dothelial growth factor(VEGF) A, tissue plasminogen fully ripe fruit(Kim HS et al 2011). Additionally, Park activation(tPA), thrombospondin 1. It revealed effec- Y et al(2008) also reported that components and tive in preventing thrombosis or various cardiovas- substance content differs by the ripened level of R. cular related illnesses. Thus, R. coreanus is concluded coreanus, which affects antioxidant effects. to have various application possibilities in related Through these studies we can see ripened levels functional foods development. of R. coreanus not only affect antioxidant activities Culinary Science and Hospitality Research, Volume 21, Number 5 165

but anti-inflammatory response as well and the ef- In national patent cases, using the registered data fects of unripe fruit is much stronger than fully ripe from January 1st 2006 to September 29th, 2015 as fruits. the standard it was evident that after 2010, patent Moreover, Park JH et al(2006) also reported that application increased significantly(Figure 1). This was unripe R. coreanus and ethanol extracts can induce due to various research results presented on R. cor- heme oxygenase-1(HO-1) expression in inflammation eanus and the rising interest of its application in induced RAW 264.7 murine macrophages by LPS to functional foods, medicine and cosmetics. Also it suppress production of iNOS, cyclooxygenase(COX)- seems to be related to the Korea’s Ministry of Food

2, NO, and PGE2(Elbirt KK, Bonkowsky HL 1999). and Drug Safety individually recognized R. coreanus Heme oxygemase(HO) is the rate-limiting enzyme in extracts as functional raw material in December heme catabolism with consequent generation of bili- 2010. Additionally from January1st, 1990 to Decem- verdin, free ion, and carbon monoxide(CO). Three ber 31st 2001, as there were only 2 patents applied mamalian HO isoforms have been identified, one of related to R. coreanus, the rapid increase of interest which, HO-1, is a stress-responsive protein endowed in R. coreanus is evident. with important cyto-protective effects. Expression of Meanwhile, according to the International Patent HO-1 in marcrophages is an element of the repair Classification(IPC) patent registration numbers it was processes that occur during the resolution of in- ranked A23(52%), A61(24%) and C12(15%) (Figure 2). flammation that leads to healing and tissue repair(Moris D, Choi AM 1968). Additionally, it is reported that not only the fruit of R. coreanus but the roots also have high anti-inflammatory activity. Kim SK et al(2013) compared anti-inflammatory activity according to different parts of R. coreanus with LPS induced inflammatory response RAW 264.7 cell. The cells were treated with concentration(1, 5, 10, 25, 50, 100 μg/mL) of separated polyphenol from 80% ethanol extract of R. coreanus roots and unripe Figure 1. Number of patents related to Rubus coreanus fruit. The result showed both root extract and unripe Miquel from 2006 to 2015.09. fruit extract displayed decrease NO, pro-inflammatory cytokine(IL-1β, IL-6, IL-10), and PGE2 production. Root extract had much stronger anti-inflammatory activity compared to the unripe fruit extract. PGE2, especially, showed excellent reducing effect (approximately 47% when compared to NO and other inflammation factors) in the lowest concentration of 1 μg/mL of R. coreanus root extract. These results confirm that R. coreanus fruit and roots can be used as effective treatment for inflammation related diseases.

Application of Rubus coreanus Miquel To investigate application prospect of R. coreanus, recent patent trend was organized and examined. Since Kwon et al(2006) presented analysis of na- Figure 2. Classfication of Rubus coreanus Miquel patents tional patent trend of R. coreanus, this study ana- according to international patent classfication (IPC) from lyzed the patent trend after 2006. 2006 to 2015.09. 166 Review on Anti-Cancer and Anti-Imflammatory Activity from Rubus coreanus Miquel

These results were similar to patent trend from 2001 ripe fruit extract. Also, R. coreanus extract did to 2006(Kwon et al 2006). not affect normal cells and only target cancer The largest portion, A23(52%), was invention per- cell strains for anti-cancer activity, which im- taining ‘Food and/or groceries; processing of those plies application possibility as natural func- not included in others’ including Berry juice com- tional material to secure safety in existing an- prising R. coreanus and manufacturing method the- ti-cancer drugs. reof(application number 1020130003461), Concen- 2. R. coreanus extract displayed anti-inflammatory trated functionality drink comprising unripened R. effects by decreasing expression of inflamma- coreanus and manufacturing method thereof(app- tion related genes and inflammation mediated lication number 1020130027732), functionality drink substances in inflammatory response induced comprising unripened R. coreanus and manufactur- macrophage. The ripened level of R. coreanus ing method thereof(application number 10201300- not only affects antioxidant activity but also an- 27731), manufacturing method for R. coreanus tea ti-inflammatory response and effect of unripe using berry and leaf of R. coreanus(application num- fruit was considerable stronger than fully ripe ber 1020070096797), etc. fruit. Additionally, roots of R. coreanus is also re- The second largest portion, A61K field of 24%, ported to have high anti-inflammatory effects was on inventions included in ‘medicine and cos- and thus, it can be used as an effective treating metics, etc’. This field is in relation to functional inflammation related diseases. product production using fixed ingredients from R. 3. Additionally, to apply various functions of R. coreanus extracts. Typical patents include A compo- coreanus, several forms of food, cosmetics and sition comprising an extract of R. coreanus potentiat- medicine is currently being developed but food ing testosterone excretion as an active ingredi- related inventions are still the mainstream. ent(application number 1020040114316), Composi- tion containing an extract of R. coreanus for prevent- As cancer holds a high possibility of metastasizing ing and treating anxiety and depression(application to various tissues, a wide-range anti-cancer therapy number 1020060041105). Additionally, in medicinal is commonly used. To decrease anti-cancer drug side products, patents include anticancer and anti-in- effects whilst maintain its effectiveness, administer- flammatory effects of R. coreanus extracts mentioned ing natural substances along with anti-cancer drug before. method is recently receiving much attention. Hence, The overall of patent trend showed that A23 and continuous studies on safe and powerful natural A61K were the main portion and A23, ‘food and gro- substances are crucial. ceries’, held up to double the ratio of A61K, ‘medi- Medicinal effects of R. coreanus has been widely cine and cosemtics, etc’. From this result, it is evi- known since antient times due to its use in oriental dent that despite its outstanding medical activity, R. medicine and home remedy. Recently, through vari- coreanus is currently used mainly in food rather than ous researches, scientific effectiveness of R. coreanus medicine or cosmetics. is constantly being proven. However, medicinal effects of R. coreanus are considered to be effective CONCLUSION when various ingredients are combined rather than a specific ingredient itself. Also, most research held was experimental and lacks in clinical research. Various studies on anti-cancer, anti-inflammation effects and patents of R. coreanus were organized. Therefore, to clearly prove usefulness of R. coreanus in humans, further studies on R. coreanus bio- 1. R. coreanus extracts displayed anti-cancer ef- logical activity index is crucial. fects mostly through cancer cell growth inhibition, DNA damage induction, and cancer ACKNOWLEDGEMENTS cell death process. And unripe fruit extract was shown to be much more effective than fully This study was conducted by Rural Development Culinary Science and Hospitality Research, Volume 21, Number 5 167

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복분자딸기(Rubus coreanus Miquel)의 항암 및 항염 효과

송유나1) 이헌옥1) 노건민2) 최정숙2) 김행란2) 엄애선1)¶ 1)¶한양대학교 생활과학대학 식품영양학과, 2)농촌진흥청 국립농업과학원 기능성식품과

국문초록

최근 암에 의한 사망률이 증가하고, 암 치료를 위한 화학적 항암제의 부작용이 지속적으로 대두됨에 따라 암 예방 뿐 아니라, 항암제의 부작용을 감소시키면서 효과는 유지시킬 수 있는 방법이 필요하다. 이를 위해 최근 천연물과 항암제의 병용투여법이 주목 받고 있으며, 보다 안전하고 효과적인 천연물질의 개발이 요구된다. 최근 복분자딸기의 항산화, 항암, 항염 등 다양한 생리활성이 부각되면서 소비가 지속적으로 증가하고 있다. 또한 이러한 생리활성을 활용하여 식품, 주류, 화장품과 의약품과 같은 분야에서 복분자딸기를 이용한 다양한 상품이 개발되고 있다. 따라서 이 고찰은 복분자딸기의 항암 및 항염증 효능에 대한 연구결과와 복분자딸기의 특허동향을 정리하였다. 향후 복분자 딸기의 열매뿐 아니라, 줄기, 잎 등 다양한 부위를 활용한 천연유래 기능성 소재 개발 및 복분자딸기의 다양한 응용가 능성을 모색하기 위한 더 많은 연구가 이루어져야 할 것으로 여겨진다.

주제어: 복분자딸기, 항염, 항암, 특허, 문헌고찰