Lectures and Seminars, Michaelmas Term 2015

Total Page:16

File Type:pdf, Size:1020Kb

Lectures and Seminars, Michaelmas Term 2015 WEDNESDay 7 octobEr 2015 • SUPPLEMENt (1) to No 5107 • VoL 146 Gazette Supplement Lectures and Seminars, Michaelmas term 2015 Witness Seminar (the UN orthopaedics, rheumatology and Islamic Studies at 70) 26 Musculoskeletal Sciences Reuters Institute for the Study of Pathology Journalism Pharmacology Reuters Institute for the Study of Charles Simonyi Lecture 26 Physiology, anatomy and Genetics Journalism/Nuffield Population Health Latin american centre Humanities 26 Psychiatry Foundation for Law, Justice and Society/ centre for Socio-Legal Studies TORCH | The Oxford Research Centre in Social Sciences 34 Learning Institute the Humanities Maison Française Rothermere American Institute anthropology and Museum Ethnography oxford Martin School Classics Archaeology Population ageing English Language and Literature Saïd Business School English/History/History of Art/Theology/ Education Colleges, Halls and Societies 44 Music Geography and the Environment all Souls/Magdalen History Intellectual Property research centre Balliol History/Politics and International Interdisciplinary Area Studies Relations Green templeton International Development (Queen Linguistics, Philology and Phonetics Elizabeth House) Keble Linguistics, Philology and Phonetics/ Law Lady Margaret Hall Medieval and Modern Languages Politics and International relations Magdalen Medieval and Modern Languages Social Policy and Intervention Mansfield Music Socio-legal Studies Nuffield Oriental Studies Sociology Oriel St Anne’s Mathematical, Physical and Department for Continuing St Antony’s Life Sciences 31 Education 39 St Cross Weldon Memorial Prize Lecture St Edmund Hall Kellogg college centre for creative St Hugh’s Chemistry Writing St John’s Earth Sciences rewley House Somerville Engineering Science Graduate Seminar Programme in the arts Mathematical Institute and Humanities University college Physics Wolfson Plant Sciences Institutes, Centres and blackfriars Hall Museums 39 Medical Sciences 32 Other Groups 48 ashmolean Museum Biochemistry bodleian Libraries Friends of the Bodleian Clinical Neurosciences coMPaS Oxford Italian Association Friends of the Pitt rivers Museum Molecular Medicine Hebrew and Jewish Studies Hindu Studies 25 26 University of Oxford Gazette • Supplement (1) to No 5107 • 7 october 2015 Witness Seminar (the UN Humanities TORCH/Bodleian Libraries at 70) a panel discussion will be held at 5pm on TORCH | The Oxford Research Centre in 29 october in the Lecture theatre, Weston a seminar will be held 9.30am–5.30pm on the Humanities Library, to celebrate the 60th anniversary of 16 october in the Lecture theatre, Weston the publication of the final volume oft olkien’s Library. Sponsors: british association of Unconscious memory seminars The Lord of the Rings. Speakers: Professor Former UN civil Servants; all Souls; bodleian UNCONSCIOus: CONCEPT OR METAPHOR? Andy Orchard, Dr Dimitra Fimi, cardiff Library; United Nations association; KcL; Metropolitan, and Dr Patrick Curry, Lampeter. Humanitarian Policy Group, oDI. chair: the following papers will be presented chair: Dr Stuart Lee. accompanied by a display Professor Sir adam roberts. Speakers: consecutively from 4.30pm to 6.45pm on of original drawings from the tolkien archive. Michael Mosselmans, christian aid; Angela 26 october in the Seminar room, radcliffe registration required: www.torch.ox.ac.uk/ Raven-Roberts, independent consultant; Humanities building, followed by drinks and tolkien. Lamees Hafeez, Manchester; David Harland, discussion. convener: Sowon Park (sowon. Subject: ‘The Lord of the Rings; tolkien’s Humanitarian Dialogue; Alan Doss, Kofia nnan [email protected]) legacy’ Foundation; Dr Nicola Dahrendorf, the Policy Professor Andrew Mayes, Manchester: TORCH/Museum of Natural History Practice; Professor Guy Goodwin-Gill; Sir ‘the neural bases of the unconscious’ John Holmes, Ditchley Foundation; Professor a public event will be held at 5.30pm on 18 Mukesh Kapila, Manchester; Michael Keating, Dr Angus Nicholls, QMUL: ‘Is the November at the Museum of Natural History to chatham House; Dr Randolph Kent, KcL. unconscious a concept or a metaphor?’ celebrate the life and legacy of the oxford dodo, conveners: Edward Mortimer; Martin barber, Humanitas along with an opportunity to view the dodo. BAFUNcS. Free but places limited. to register: Speakers: Paul Smith, Pietro Corsi, Jasper www.bodleian.ox.ac.uk/whatson/whats-on/ VISITING PROFEssOrshIP IN MusEUMS, Fforde, author, Paul Jepson, Environmental upcoming-events/2015/oct/un-at-70. GALLERIES AND LIBrarIES LECTURE researcher, and Kirsten Shepherd-Barr. Part Subject: ‘the UN and humanitarian action: SERIES: THE RISE AND fall OF Adam of being Human, the nationwide festival of the learning lessons from past experience for AND EvE humanities. registration required: http://torch. ox.ac.uk/dodo. future policy’ Professor Stephen Greenblatt, Harvard, will Subject: ‘the oxford dodo: culture at the give the following lectures. More information crossroads’ Charles Simonyi Lecture and to register: www.torch.ox.ac.uk/ humanitas/museums-galleries-and-libraries. Rothermere American Institute 5.30pm, 19 Oct, Blackwell Hall, Weston Melissa Franklin, Mallinckrodt Professor of Library: ‘In the bathhouse’ Physics, Harvard, will deliver the 2015 charles the following events will take place at the Simonyi Lecture at 5pm on 5pm, 20 Oct, South School, Examination rothermere american Institute, unless otherwise noted. 6 November at the oxford Playhouse. Schools: ‘Getting real’ tickets: £7 (£5 concessions) from www. TORCH/Museum of the History of Science Harmsworth Lecture in American History oxfordplayhouse.com/theatre/3456/Putting- Professor Kristin Hoganson, Illinois, will the-Higgs-boson-in-its-place. Dr Silke Ackermann, Dr Liz Bruton and deliver her inaugural lecture as Harmsworth Subject: ‘Putting the Higgs boson in its Professor Nigel Biggar will discuss the ethics Visiting Professor of american History at 5pm place’ of scientists going to war, in response to the current Museum of the History of Science on 17 November in the Examination Schools. exhibition exploring the life and legacy of Subject: ‘Isolationism as an urban legend’ Henry Moseley, at 7pm on American Literature research seminar 13 october in the Museum of the History of Science. registration required: http://torch. the following seminars will be held at 5.30pm ox.ac.uk/too-valuable-die. on thursdays in the large seminar room. Subject: ‘too valuable to die? the ethics of conveners: Jurrit Daalder, christine Fouirnaies science and scientists going to war’ Professor Nancy Bentley, Pennsylvania TORCH/Worcester 15 Oct: 'Kinship politics: Jewett, Zitkala-Sa and literary clans' Professor Oliver Taplin and Professor Seamus Perry will lead a roundtable Dr Thomas Karshan, East anglia discussion at 6pm on 16 october at the 29 Oct: 'Neither snow nor rain nor heat nor Mathematical Institute to celebrate the gloom of night: american writers at the publication of Professor Jonathan bate’s Ted dead letter office’ Hughes: An Unauthorised Life. registration Benjamin Markovits required: http://torch.ox.ac.uk/tedhughes. 5 Nov: Discussion of his new novel You Subject: ‘ted Hughes: the unauthorised life’ Don’t Have To Live Like This Dr Stephen Burn, Glasgow 26 Nov: 're-reading the core texts: american fiction after the decade of the brain' University of Oxford Gazette • Supplement (1) to No 5107 • 7 october 2015 27 Special events Faculty of Classics Faculty of English Language and Literature Dr Robert Scott, adelphi the following events will take place at the 3pm, 23 Oct: ‘american higher education: Ioannou centre for classical and byzantine Professor of Poetry Lecture observations from the field’. Followed by Studies, 66 St Giles’. a round-table discussion led by Dr Gail Professor Simon Armitage will deliver his Mellow, LaGuardia, Professor Margaret APGRD free public lectures inaugural Professor of Poetry Lecture at 5.30pm on 24 November in the Examination MacMillan and Darryl Greer, Stockton. the following free public lectures will be given Schools. Professor Don Doyle, South carolina at 2.15pm on Mondays in the Lecture theatre. Clarendon Lectures in English: Psyche and 4pm, 26 Oct: ‘the cause of all nations: an Marina Carr, playwright Ethos international history of the american civil 12 Oct: In conversation about her new War’ version of Euripides’ Hecuba Professor Amanda Anderson, andrew W Mellon Professor of Humanities and English Tim Griffin, Lt Gov, arkansas Adele Thomas, director, and Rory Mullarkey, and Director, cogut center for the Humanities, 12.30pm, 5 Nov: ‘congress, constituents and playwright brown, will deliver the clarendon Lectures the constitution: thoughts on the House 2 Nov: ‘on the Globe theatre’s production of in English at 5.15pm on the following days in republican majority, 2010–present’ The Oresteia’ room 6, Examination Schools. Dr Stella Krepp, bern Professor Peter Wiseman 10 Nov: ‘Psychology contra morality’ 5pm, 5 Nov: ‘From the western hemisphere 9 Nov: ‘rhinthon and the roman audience’ (followed by a drinks reception) to the west: the United States and Latin america, 1941–9’ APGRD seminar series: Reception and 12 Nov: ‘In the middle of life’ scholarship Book launch 17 Nov: ‘Psychic life and the claims of others’ Professor Celeste-Marie Bernier, Nottingham the following seminars will be given at 5pm 19 Nov: ‘a human science’ 5pm, 23 Nov: ‘Suffering and sunset: World on Mondays in the First Floor Seminar room. War I in the art and life of Horace Pippin’ conveners: Professor Fiona Macintosh, Dr
Recommended publications
  • Old Road Campus
    Old Road Campus 4a, 4b, 4c, U5 n o t Oxford City Centre g OLD ROAD n i d 4a, 4b, 4c, U5 a e H K O L L A D R O W AD E M I L 4,4a,4b,4c, U1X,U5 A41 42 4,4a,4b,4c,U5 Rin D 4 g R oad 6 7 1 13 3 11 C H U R C H I L L 900 D 2 R I 700, 900 V E E O x f o 5 A C rd 12 C i ty 10 C e n t re B 8 CAR PARK C 9 h u r c R F h i O l l O S H E o V s N E p L i T t DRI a VE ENTRANCE ROOSEVELT DRIVE l 900, ST2 Index 1 The Triangle Nursery 9 Old Road Campus Estates Annexe 13 Boundary Brook House Interserve Joint Research Office Kennedy Institute 2 - Research Services, Medical Sciences Division Old Road Campus Research Building 10 - Clinical Trials and Research Governance 3 New Richards Building Department of Oncology - Human Tissue Governance CRUK/MRC Oxford Institute for Radiation Oncology - Medical Sciences Division Business Development 4 NDM Research Building Institute of Biomedical Engineering Nuffield Department of Primary Care Health Sciences Target Discovery Institute Jenner Institute Medical Sciences Divisional Safety Officers Centre for Tropical Medicine and Global Health Bodleian Knowledge Centre (Library Services) Medical Sciences Division IT Services 5 Wellcome Centre for Human Genetics (WHG) Ludwig Institute for Cancer Research Structural Genomics Consortium 6 Henry Wellcome Building for Molecular Physiology Nuffield Department of Surgical Sciences Loading Bays and Delivery Offices of the Nuffield Professor of Medicine ENTRANCE VIA BUILDING 5 11 Big Data Institute A Wellcome Trust Centre for Human Genetics 7 Henry Wellcome Building for Particle Imaging
    [Show full text]
  • Lectures and Seminars, Trinity Term 2015
    WEDNESDay 22 april 2015 • SUpplEMENT (2) TO NO 5092 • VOl 145 Gazette Supplement Lectures and Seminars, Trinity term 2015 Romanes Lecture 462 Experimental psychology Buddhist Studies Orthopaedics, rheumatology and COMPAS Musculoskeletal Sciences Hebrew and Jewish Studies University Administration pathology Hindu Studies and Services 462 pharmacology Museum of the History of Science Disability Lecture physiology, anatomy and Genetics islamic Studies population Health reuters institute for the Study of Humanities 462 psychiatry Journalism Foundation for law, Justice and Society TOrCH | The Oxford research Centre in Social Sciences 470 the Humanities learning institute Maison Française rothermere american institute interdisciplinary research Methods Oxford Martin School Classics Sanjaya lall Memorial Trust population ageing English language and literature anthropology and Museum Ethnography ian ramsey Centre History Saïd Business School linguistics, philology and phonetics Economics Colleges, Halls and Societies 482 Medieval and Modern languages Education Music interdisciplinary area Studies all Souls Oriental Studies international Development (Queen Balliol philosophy Elizabeth House) Green Templeton Theology and religion Oxford internet institute Keble Law lady Margaret Hall Mathematical, Physical and politics and international relations linacre Life Sciences 466 Social policy and intervention lincoln Socio-legal Studies Chemistry Magdalen Sociology Computer Science Mansfield Nuffield Earth Sciences Department for Continuing Queen’s Engineering
    [Show full text]
  • IRR-Issue-8-October-2019.Pdf
    INTERRELIGIOUS RELATIONS Occasional Papers of The Studies in Interreligious Relations in Plural Societies Programme Western Perspectives on Dialogue in a World of Conflict and Violence Gavin Flood ISSN: 2661345X Editors: Professor Abdullah Saeed, University of Melbourne, Australia, and Advisor to the SRP Programme, RSIS, Nanyang Technological University, Singapore Dr Paul Hedges, SRP Programme, RSIS, Nanyang Technological University, Singapore Editorial Assistant: Nursheila Muez, SRP Programme, RSIS, Nanyang Technological University, Singapore Advisory Board: Ambassador Mohammad Alami Musa, SRP Programme, RSIS, Nanyang Technological University, Singapore Ambassador Barry Desker, RSIS, Nanyang Technological University, Singapore Rt Rev Dr John Chew, Emeritus, Trinity Theological College, Singapore Professor Lily Kong, Singapore Management University, Singapore Professor Joseph Liow Chin Yong, College of Humanities, Arts and Social Sciences (COHASS), and RSIS, Nanyang Technological University, Singapore Professor Julius Lipner, Emeritus, University of Cambridge, UK Editorial Board: Dr Mohamed Ali, SRP Programme, RSIS, Nanyang Technological University, Singapore Professor Scott Appleby, Keough School of Global Affairs, University of Notre Dame, USA Professor Azyumardi Azra, Syarif Hidayatullah State Islamic University Jakarta, Indonesia Dr Lang Chen, Hong Kong Polytechnic University, Hong Kong Professor Catherine Cornille, Boston College, USA Professor Gavin D’Costa, Bristol University, UK Professor Farid Esack, University of Johannesburg,
    [Show full text]
  • THE 422 Mps WHO BACKED the MOTION Conservative 1. Bim
    THE 422 MPs WHO BACKED THE MOTION Conservative 1. Bim Afolami 2. Peter Aldous 3. Edward Argar 4. Victoria Atkins 5. Harriett Baldwin 6. Steve Barclay 7. Henry Bellingham 8. Guto Bebb 9. Richard Benyon 10. Paul Beresford 11. Peter Bottomley 12. Andrew Bowie 13. Karen Bradley 14. Steve Brine 15. James Brokenshire 16. Robert Buckland 17. Alex Burghart 18. Alistair Burt 19. Alun Cairns 20. James Cartlidge 21. Alex Chalk 22. Jo Churchill 23. Greg Clark 24. Colin Clark 25. Ken Clarke 26. James Cleverly 27. Thérèse Coffey 28. Alberto Costa 29. Glyn Davies 30. Jonathan Djanogly 31. Leo Docherty 32. Oliver Dowden 33. David Duguid 34. Alan Duncan 35. Philip Dunne 36. Michael Ellis 37. Tobias Ellwood 38. Mark Field 39. Vicky Ford 40. Kevin Foster 41. Lucy Frazer 42. George Freeman 43. Mike Freer 44. Mark Garnier 45. David Gauke 46. Nick Gibb 47. John Glen 48. Robert Goodwill 49. Michael Gove 50. Luke Graham 51. Richard Graham 52. Bill Grant 53. Helen Grant 54. Damian Green 55. Justine Greening 56. Dominic Grieve 57. Sam Gyimah 58. Kirstene Hair 59. Luke Hall 60. Philip Hammond 61. Stephen Hammond 62. Matt Hancock 63. Richard Harrington 64. Simon Hart 65. Oliver Heald 66. Peter Heaton-Jones 67. Damian Hinds 68. Simon Hoare 69. George Hollingbery 70. Kevin Hollinrake 71. Nigel Huddleston 72. Jeremy Hunt 73. Nick Hurd 74. Alister Jack (Teller) 75. Margot James 76. Sajid Javid 77. Robert Jenrick 78. Jo Johnson 79. Andrew Jones 80. Gillian Keegan 81. Seema Kennedy 82. Stephen Kerr 83. Mark Lancaster 84.
    [Show full text]
  • IFS 172: Religions from India: Schedule
    IFS 172: Religions from India: Schedule http://www4.westminster.edu/staff/brennie/REL172/rel172Fall2020.htm... RELIGIONS FROM INDIA FALL 2020 INTERFAITH STUDIES 172 Classes will begin Monday, August 17, and conclude with finals just before Thanksgiving. There will be no fall midterm break. Fall semester classes will end Friday, Nov. 20, and final exams will take place Saturday, Nov. 21 through Wednesday, Nov. 25. Reading Course Description Grading Schedule The Term Paper Vocabulary Students are recommended NOT to print out this syllabus as it may change during the semester. However, if, for any reason, you really do need a printed copy, click this link for a Pdf formatted version. REQUIRED READING: Gavin Flood, An Introduction to Hinduism. Cambridge University Press, 1996. ISBN-10: 0521438780, ISBN-13: 978-0521438780. Richard Robinson, Willard Johnson, and Thanissaro Bikkhu, Buddhist Religions: A Historical Introduction. Wadsworth, 2004. ISBN-10: 0534558585, ISBN-13: 978-0534558581 Various Sacred Scriptures of the Hindu and Buddhist traditions that will be provided on D2L. RECOMMENDED READING: Wendy Doniger, The Rig Veda and The Laws of Manu (with Brian K. Smith). Robert Ernest Hume, The Thirteen Principal Upanishads. de Bary, William Theodore, Sources of Indian Tradition. Brockington, John, The Sacred Thread. Eliade, Mircea, Yoga, Immortality, and Freedom. Stoler-Miller, Barbara, The Bhagavadgita. Patanjali, The Yoga Sutra of Patanjali. Edward Conze, Buddhist Texts through the Ages. E. A. Burtt, The Teachings of the Compassionate Buddha. Walpola Rahula, What the Buddha Taught. Sue Hamilton, Early Buddhism: A New Approach. Donald Lopez (ed.), Critical Terms for the Study of Buddhism. ON-LINE RESOURCES: Religious Tolerance.Org V.
    [Show full text]
  • Daily Report Thursday, 14 January 2021 CONTENTS
    Daily Report Thursday, 14 January 2021 This report shows written answers and statements provided on 14 January 2021 and the information is correct at the time of publication (06:29 P.M., 14 January 2021). For the latest information on written questions and answers, ministerial corrections, and written statements, please visit: http://www.parliament.uk/writtenanswers/ CONTENTS ANSWERS 7 Police and Crime BUSINESS, ENERGY AND Commissioners: Elections 15 INDUSTRIAL STRATEGY 7 Schools: Procurement 16 Additional Restrictions Grant 7 Veterans: Suicide 16 Business: Coronavirus 7 DEFENCE 17 Business: Grants 8 Armed Forces: Health Conditions of Employment: Services 17 Re-employment 9 Defence: Expenditure 17 Industrial Health and Safety: HMS Montrose: Repairs and Coronavirus 9 Maintenance 18 Motor Neurone Disease: HMS Queen Elizabeth: Research 10 Repairs and Maintenance 18 Podiatry: Coronavirus 11 DIGITAL, CULTURE, MEDIA AND Public Houses: Coronavirus 11 SPORT 19 Wind Power 12 British Telecom: Disclosure of Information 19 CABINET OFFICE 13 Broadband: Elmet and Civil Servants: Business Rothwell 20 Interests 13 Broadband: Greater London 20 Coronavirus: Disease Control 13 Chatterley Whitfield Colliery 21 Coronavirus: Lung Diseases 13 Data Protection 22 Debts 14 Educational Broadcasting: Fisheries: UK Relations with Coronavirus 23 EU 14 Events Industry and Iron and Steel: Procurement 14 Performing Arts: Greater National Security Council: London 23 Coronavirus 15 Football: Dementia 24 Football: Gambling 24 Organic Food: UK Trade with Freedom of Expression
    [Show full text]
  • Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent
    1128 Diabetes Volume 67, June 2018 Adrenaline Stimulates Glucagon Secretion by Tpc2- Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic a-Cells Alexander Hamilton,1 Quan Zhang,1 Albert Salehi,2 Mara Willems,1 Jakob G. Knudsen,1 Anna K. Ringgaard,3,4 Caroline E. Chapman,1 Alejandro Gonzalez-Alvarez,1 Nicoletta C. Surdo,5 Manuela Zaccolo,5 Davide Basco,6 Paul R.V. Johnson,1,7 Reshma Ramracheya,1 Guy A. Rutter,8 Antony Galione,9 Patrik Rorsman,1,2,7 and Andrei I. Tarasov1,7 Diabetes 2018;67:1128–1139 | https://doi.org/10.2337/db17-1102 Adrenaline is a powerful stimulus of glucagon secretion. It The ability of the “fight-or-flight” hormone adrenaline to acts by activation of b-adrenergic receptors, but the down- increase plasma glucose levels by stimulating liver gluconeo- stream mechanisms have only been partially elucidated. genesis is in part mediated by glucagon, the body’sprincipal Here, we have examined the effects of adrenaline in mouse hyperglycemic hormone (1). Glucagon is secreted by the and human a-cells by a combination of electrophysiology, a-cells of the pancreas (2). Reduced autonomic stimulation 2+ imaging of Ca and PKA activity, and hormone release of glucagon secretion may result in hypoglycemia, a serious measurements. We found that stimulation of glucagon and potentially fatal complication of diabetes (3). It has been secretion correlated with a PKA- and EPAC2-dependent estimated that up to 10% of insulin-treated patients die of (inhibited by PKI and ESI-05, respectively) elevation of hypoglycemia (4). Understanding the mechanism by which [Ca2+] in a-cells, which occurred without stimulation of i adrenaline stimulates glucagon secretion and how it becomes ISLET STUDIES electrical activity and persisted in the absence of extracel- perturbed in patients with diabetes is therefore essential.
    [Show full text]
  • Peter Hitchens on Whether the European Argues That Great Britain the Union Has Changed Britain Is a Nation in Decline Progressive Conscience
    DAMIAN GREEN MP PETER HITCHENS on whether the European argues that Great Britain The Union has changed Britain is a nation in decline Progressive Conscience From Global Empire to the Global Race: modern Britishness john redwood mp | professor tim bale | daniel hannan mep | stephen crabb mp Contents 03 Editor’s introduction 18 Daniel Hannan: To define Contributors James Brenton Britain, look to its institutions PROF TIM BALE holds the Chair James Brenton politics in Politics at Queen Mary 20 Is Britain still Great? University of London 04 Director’s note JAMES BRENTON is the editor of Peter Hitchens and Ryan Shorthouse Ryan Shorthouse The Progressive Conscience 23 Painting a picture of Britain NICK CATER is Director of 05 Why I’m a Bright Blue MP the Menzies Research Centre Alan Davey George Freeman MP in Australia 24 What’s the problem with STEPHEN CRABB MP is Secretary 06 Replastering the cracks in the North of State for Wales promoting British values? Professor Tim Bale ROSS CYPHER-BURLEY was Michael Hand Spokesman to the British 07 Time for an English parliament Embassy in Tel Aviv 25 Multiple loyalties are easy John Redwood MP ALAN DAVEY is the departing Damian Green MP Arts Council Chief Executive 08 Britain after the referendum WILL EMKES is a writer 26 Influence in the Middle East Rupert Myers GEORGE FREEMAN MP is the Ross Cypher-Burley Minister for Life Sciences 09 Patriotism and Wales DR ROBERT FORD lectures at 27 Winning friends in India Stephen Crabb MP the University of Manchester Emran Mian DAMIAN GREEN MP is the 10 Unionism
    [Show full text]
  • Synthesis of the Ca -Mobilizing Messengers NAADP
    ARTICLE cro Author’s Choice Synthesis of the Ca2؉-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in ␤-adrenoceptor signaling Received for publication, April 3, 2017, and in revised form, May 13, 2017 Published, Papers in Press, May 24, 2017, DOI 10.1074/jbc.M117.789347 Wee K. Lin‡, Emma L. Bolton‡, Wilian A. Cortopassi§¶, Yanwen Wangʈ, Fiona O’Brien‡, Matylda Maciejewska‡, Matthew P. Jacobson¶, Clive Garnham‡, Margarida Ruas‡, John Parrington‡, Ming Lei‡1, Rebecca Sitsapesan‡2, Antony Galione‡3, and Derek A. Terrar‡4 From the ‡Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom, the §Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom, the ¶Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, and the ʈFaculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9NT, United Kingdom Edited by Roger J. Colbran Nicotinic acid adenine dinucleotide phosphate (NAADP) and increase both Ca2؉ transients and the tendency to disturb .cyclic ADP-ribose (cADPR) are Ca2؉-mobilizing messengers heart rhythm important for modulating cardiac excitation–contraction cou- pling and pathophysiology. CD38, which belongs to the ADP- ribosyl cyclase family, catalyzes synthesis of both NAADP and ADP-ribosyl cyclases (ARCs)5 are enzymes capable of con- cADPR in vitro. However, it remains unclear whether this is the verting NAD into cyclic adenosine diphosphate ribose main enzyme for their production under physiological condi- (cADPR). In addition, some of these cyclases (for example, tions. Here we show that membrane fractions from WT but not CD38 and Aplysia cyclase), can (at least under in vitro condi- ؊/؊ CD38 mouse hearts supported NAADP and cADPR synthe- tions) also produce nicotinic acid adenine dinucleotide phos- sis.
    [Show full text]
  • Oxford CENTRE for HINDU STUDIES ONLINE COURSES
    Oxford Centre for Hindu Studies Online Courses Prospectus 2021 Bhagavad-gita The Gita’s explanation of belief and Tutor: Dr Layne Little practice has had a huge influence Course creator: Dr Nick Sutton on Hindu thought. We study the Weekly Sessions: 7 main themes of Krishna’s teachings Course notes: 153pp and the principal ideas within the Video: 5hr 14min eighteen chapters (700 verses) of Pathways: Sacred Texts | Yoga Studies Bhagavad Gita. You are provided Optional assessment: 2000 word essay with a full English translation of the Total estimated study time: 37 hours Gita and discussions of the meaning and significance of these verses. We also reflect on the contemporary significance of the teachings and their relevance to the modern world. Discovering Ancient Temples In this course we learn about Tutor: Prof. Himanshu Prabha Ray Hinduism through the prism of Course creator: Prof. Himanshu Prabha Ray archaeology. We explore the Weekly Sessions: 7 multiple identities of sacred sites Course notes: 97pp and how these are negotiated. We Video: 4hr 27min learn how archaeology can uncover Pathways: Culture | History changes in ritual, transformations Optional assessment: 2000 word essay in diet, and changes in how sacred Total estimated study time: 29 hours spaces are used. The texts tell us only part of the story, the stones tell their own tales. Hindu Devotional Music & Chant This course presents a historical and Tutor: Dr Guy Beck theoretical study of Hindustani chant Course creator: Dr Guy Beck and music. We begin with sacred Weekly Sessions: 7 sound in ancient India and proceed Course notes: 111pp to important forms of chant and Video: 8hr 38min devotional music that have developed Pathways: Culture since.
    [Show full text]
  • Metabolic Tracing of NAD Precursors Using Strategically Labelled Isotopes of NMN
    A thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy Metabolic tracing of NAD+ precursors using strategically labelled isotopes of NMN by Lynn-Jee Kim Supervisors Dr. Lindsay E. Wu (Primary) Prof. David A. Sinclair (Joint-Primary) Dr. Lake-Ee Quek (Co-supervisor) School of Medical Sciences Faculty of Medicine Thesis/Dissertation Sheet Surname/Family Name: Kim Given Name/s: Lynn-Jee Abbreviation for degree as give in PhD the University calendar: Faculty: Faculty of Medicine School: School of Medical Sciences + Thesis Title: Metabolic tracing of NAD precursors using strategically labelled isotopes of NMN Abstract 350 words maximum: (PLEASE TYPE) Nicotinamide adenine dinucleotide (NAD+) is an important cofactor and substrate for hundreds of cellular processes involved in redox homeostasis, DNA damage repair and the stress response. NAD+ declines with biological ageing and in age-related diseases such as diabetes and strategies to restore intracellular NAD+ levels are emerging as a promising strategy to protect against metabolic dysfunction, treat age-related conditions and promote healthspan and longevity. One of the most effective ways to increase NAD+ is through pharmacological supplementation with NAD+ precursors such as nicotinamide mononucleotide (NMN) which can be orally delivered. Long term administration of NMN in mice mitigates age-related physiological decline and alleviates the pathophysiologies associated with a high fat diet- and age-induced diabetes. Despite such efforts, there are certain aspects of NMN metabolism that are poorly understood. In this thesis, the mechanisms involved in the utilisation and transport of orally administered NMN were investigated using strategically labelled isotopes of NMN and mass spectrometry.
    [Show full text]
  • Sabbatical Panorama 2013-2014
    Sabbatical Panorama 2013•2014 i Table of Contents Provost’s Introduction ................................................................................................................................................................ i Simone A. James Alexander ................................................................................................................................................. 1 Assefaw Bariagaber ................................................................................................................................................................ 3 David Bénéteau......................................................................................................................................................................... 6 Alan Brill ...................................................................................................................................................................................... 7 Janine P. Buckner ................................................................................................................................................................... 12 Martha C. Carpentier ............................................................................................................................................................ 16 Colleen Conway ...................................................................................................................................................................... 18 Jorge López Cortina .............................................................................................................................................................
    [Show full text]