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Index

Old Road Campus Estates Annexe

Interserve

The Triangle Nursery

Boundary Brook House

Joint Research Oﬃce

12
13

Kennedy Institute

- Research Services, Medical Sciences Division - Clinical Trials and Research Governance - Human Tissue Governance - Medical Sciences Division Business Development

Nuﬃeld Department of Primary Care Health Sciences Medical Sciences Divisional Safety Oﬃcers

Medical Sciences Division IT Services

Old Road Campus Research Building

Department of Oncology

CRUK/MRC Oxford Institute for Radiation Oncology

Institute of Biomedical Engineering Jenner Institute

Bodleian Knowledge Centre (Library Services) Ludwig Institute for Cancer Research Structural Genomics Consortium

Nuﬃeld Department of Surgical Sciences

New Richards Building

NDM Research Building

Target Discovery Institute Centre for Tropical Medicine and Global Health

Wellcome Centre for Human Genetics (WHG)

Loading Bays and Delivery

Henry Wellcome Building for Molecular Physiology

Oﬃces of the Nuﬃeld Professor of Medicine

Wellcome Trust Centre for Human Genetics Richard Doll Building

ABCDE

ENTRANCE VIA BUILDING

Big Data Institute

11 12

Henry Wellcome Building for Particle Imaging

Innovation Building

- Multi-storey car-park (authorised users only) - Kitchen facilities Bioescalator Novo Nordisk

ENTRANCE VIA BUILDING

Old Road Campus Research Building NDM Research Building

Richard Doll Building

Nuﬃeld Department of Population Health

Cancer Epidemiology Unit Clinical Trial Service Unit

Kennedy Institute

Oxford University Security Services

Innovation Building

National Perinatal Epidemiology Unit Regius Professor

Cycle Racks Café
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Recommended publications

Endoscopy Disease Detection Challenge 2020

ENDOSCOPY DISEASE DETECTION CHALLENGE 2020 Sharib Ali1 Noha Ghatwary7 Barbara Braden2 Dominique Lamarque3 Adam Bailey 2 Stefano Realdon4 Renato Cannizzaro 5 Jens Rittscher1 Christian Daul6 James East 2 1 Institute of Biomedical Engineering, Big Data Institute, University of Oxford, Old Road Campus, Oxford, UK 2 Translational Gastroenterology Unit, Experimental Medicine Div., John Radcliffe Hospital, University of Oxford, Oxford, UK 3 Universite´ de Versailles St-Quentin en Yvelines, Hopitalˆ Ambroise Pare,´ France 4 Instituto Onclologico Veneto, IOV-IRCCS, Padova, Italy 5 CRO Centro Riferimento Oncologico IRCCS Aviano Italy 6 CRAN UMR 7039, University of Lorraine, CNRS, Nancy, France 7 University of Lincoln, UK ABSTRACT improve current medical practices and reﬁne health-care Whilst many technologies are built around endoscopy, there systems worldwide. However, well-annotated, representative is a need to have a comprehensive dataset collected from publicly available datasets for disease detection for assessing multiple centers to address the generalization issues with research reproducibility and facilitating standardized com- most deep learning frameworks. What could be more im- parison of methods is still lacking. Many methods to detect portant than disease detection and localization? Through diseased regions in endoscopy have been proposed however our extensive network of clinical and computational experts, these have been primarily focused on the task of polyp we have collected, curated and annotated gastrointestinal detection in the gastrointestinal tract with demonstration on endoscopy video frames. We have released this dataset and datasets acquired from at most a few data centers and single have launched disease detection and segmentation challenge modality imaging, most commonly white light. Here, we EDD20201 to address the limitations and explore new di- present our multi-class, multi-organ and multi-population rections.
Astrazeneca-Oxford Vaccine Approved for Use in the U.K

P2JW366000-6-A00100-17FFFF5178F ****** THURSDAY,DECEMBER 31,2020~VOL. CCLXXVI NO.154 WSJ.com HHHH $4.00 DJIA 30409.56 À 73.89 0.2% NASDAQ 12870.00 À 0.2% STOXX 600 400.25 g 0.3% 10-YR. TREAS. À 3/32 , yield 0.926% OIL $48.40 À $0.40 GOLD $1,891.00 À $10.50 EURO $1.2300 YEN 103.21 Deadly Attack at Airport Targets New Yemen Government U.S. IPO What’s News Market Reaches Business&Finance Record nvestorspiled into IPOs Iat a record rate in 2020, with companies raising Total $167.2 billion via 454 of- ferings on U.S. exchanges this year through Dec. 24. Few see signs of letup Few expect the euphoria after companies raise to wear off soon. A1 more than $167 billion Detenteisending in the global fight over tech taxes, despite pandemic with Franceresuming collec- tion of itsdigital-services tax BY MAUREEN FARRELL and the U.S. poised to retali- atewith tariffs.Other coun- Defying expectations,inves- tries areset to join the fray. A1 S tors piled intoinitial public of- China finished 2020 PRES feringsatarecordrateiN with a 10th consecutive TED 2020, and few expect the eu- month of expansion in its CIA phoria to wear off soon. manufacturing sector. A7 SO Companies raised $167.2 AS TheEUand China agreed TENSIONS HIGH: People fled after an explosion Wednesday at the airport in Aden, Yemen, moments after members of the billion through 454 offerings in principle on an invest- country’s newly sworn-in cabinet arrived. At least 22 people were killed, but all the members of the cabinet were safe.
Annual Meeting

Volume 97 | Number 5 Volume VOLUME 97 NOVEMBER 2017 NUMBER 5 SUPPLEMENT SIXTY-SIXTH ANNUAL MEETING November 5–9, 2017 The Baltimore Convention Center | Baltimore, Maryland USA The American Journal of Tropical Medicine and Hygiene The American Journal of Tropical astmh.org ajtmh.org #TropMed17 Supplement to The American Journal of Tropical Medicine and Hygiene ASTMH FP Cover 17.indd 1-3 10/11/17 1:48 PM Welcome to TropMed17, our yearly assembly for stimulating research, clinical advances, special lectures, guests and bonus events. Our keynote speaker this year is Dr. Paul Farmer, Co-founder and Chief Strategist of Partners In Health (PIH). In addition, Dr. Anthony Fauci, Director of the National Institute of Allergy and Infectious Diseases, will deliver a plenary session Thursday, November 9. Other highlighted speakers include Dr. Scott O’Neill, who will deliver the Fred L. Soper Lecture; Dr. Claudio F. Lanata, the Vincenzo Marcolongo Memorial Lecture; and Dr. Jane Cardosa, the Commemorative Fund Lecture. We are pleased to announce that this year’s offerings extend beyond communicating top-rated science to direct service to the global community and a number of novel events: • Get a Shot. Give a Shot.® Through Walgreens’ Get a Shot. Give a Shot.® campaign, you can not only receive your free flu shot, but also provide a lifesaving vaccine to a child in need via the UN Foundation’s Shot@Life campaign. • Under the Net. Walk in the shoes of a young girl living in a refugee camp through the virtual reality experience presented by UN Foundation’s Nothing But Nets campaign.
Jenner Institute Complementary Vaccines Platform Technologies

WHO R&D Blueprint: Janssen Vaccines – Jenner Institute complementary Vaccines Platform Technologies Janssen Vaccines: Jenner Institute: Olga Popova Prof. Sarah Gilbert Jerome Custers WHO Geneva, 21 July 2016 Background • Jenner Institute & Janssen Vaccines presented respective proposals to WHO R&D Blueprint Workshop in April 2016, and were invited to join forces for Round 2 submission • Example of alignment, coordination and partnership between public and private sector stakeholders • Understanding nature of vaccine development, established complementary end‐to‐end skills and capabilities • Long‐term, sustainable & consistent approach and funding • High‐level flexible proposal with illustrative examples • «Bona fide»: collaborative framework to be developed JOINTLY TOWARDS TANGIBLE OUTCOMES x GLOBAL PUBLIC HEALTH 2 Success factors • Available platforms and previous experience with pathogens • Ability to invest time and resources, leverage expertise, minimise opportunity costs and ensure business continuity • Appropriate and functionable operational model, speed • Lean governance, partner alignment and milestone orientation INTERNAL • Reliable & qualified partners, durable commitments • Long‐term reliable funding (min 5‐year horizon) • Resolving vaccination indemnification / liability issue • Consistency in pathogen prioritisation and defined, consistent pre‐ established endpoint commitment • Clear and accelerated / streamlined regulatory pathways, conditions & predictability of licensure EXTERNAL • Anticipated deployment plans and community
Archaeology in Oxford Oxford City Report to the Oxford City and County Archaeological Forum February-June 2021

Archaeology in Oxford Oxford City report to the Oxford City and County Archaeological Forum February-June 2021 The impact of Covid 19 on archaeological work in the city The Urban Design and Heritage Team has continued to work remotely from home since the February OCCAF update with normal service levels being maintained. National Planning Policy Framework related field work in Oxford Armstrong Road, Littlemore Between January and May further intermittent archaeological excavation was undertaken around the site of Busy Bees Nursery on Armstrong Road by Oxford Archaeology. A number of pits of Early/Middle Iron Age date were recorded, forming part of a domestic settlement. Above: Early Iron Age pits recorded at Armstrong Road. Images courtesy of Oxford Archaeology. Warneford Hospital In February an evaluation trench was excavated by John Moore Heritage Services on land to the south of Warneford Hospital. The trench was required in advance of a hospital extension because of the potential Roman remains in this area, no significant archaeological remains were noted Old Road Campus Plot B1 In February trial trenching was undertaken by Oxford Archaeology prior to the construction of new University buildings at Old Road Campus. The work was required because of the general potential for prehistoric and Roman remains in this location. No significant archaeological deposits were noted. St Peter's College Castle Hill House, In February historic building recording was undertaken at Castle Hill House by Oxford Archaeology. The 19th century house is due to be demolished as part of the redevelopment of the site by St Peter’s College. The location of a documented 18th-19th century tunnel running under Bulwark’s Lane was confirmed (visible as a semi-circular damp patch in Bulwarks Lane) and recorded.
Sir Bryn Terfel Premieres John Rutter's 'Joseph's Carol', Dedicated to the Oxford Vaccine Team in Celebratory Concert Fr

Sir Bryn Terfel premieres John Rutter’s ‘Joseph’s Carol’, dedicated to the Oxford vaccine team in celebratory concert from the Oxford Philharmonic Orchestra Friday 18 December 2020, 18:30 Streamed on Oxford Philharmonic Orchestra’s YouTube Channel: bit.ly/OPOVaccineTribute Elgar Chanson de Matin William Henry Monk Abide with Me Rodgers & Hammerstein You’ll Never Walk Alone John Rutter Joseph’s Carol WORLD PREMIERE John Rutter Look to the Day Handel Hallelujah Chorus Sir Bryn Terfel bass-baritone Oxford Philharmonic Orchestra Maxim Vengerov violin Choir of Merton College, Oxford John Rutter conductor Alexandra Lowe soprano Marios Papadopoulos conductor Alexander Olleson treble John Suchet presenter In recognition of the formidable work accomplished by the team of scientists at the University of Oxford on their Covid-19 vaccine, the Oxford Philharmonic Orchestra will stream a celebratory concert on Friday 18 December, recorded in the city’s historic Sheldonian Theatre. Performed by bass-baritone Sir Bryn Terfel, the short concert features the premiere of John Rutter’s Joseph’s Carol, written in tribute to the Oxford Vaccine Group, the Jenner Institute and the RECOVERY team. The words by John Rutter recount the long and weary journey of Joseph and Mary to Bethlehem before the birth of the baby Jesus, echoing the programme’s journey from struggle through to hope. Bryn Terfel also joins the Orchestra and the Choir of Merton College, Oxford, in a rousing programme from Rodgers & Hammerstein’s You’ll Never Walk Alone (with Jette Parker Young Artist Alexandra Lowe) to Handel’s Hallelujah Chorus. Sir Bryn and the Orchestra are also joined in the hymn of comfort, Abide with Me, by chorister Alexander Olleson of Christ Church Cathedral Choir, the recent winner of BBC Young Chorister Of The Year 2020.
Immunomodulatory Effects of the Hepatitis C Virus (HCV) Core Protein

Immunomodulatory Effects of the Hepatitis C Virus (HCV) Core Protein By Rachel Elizabeth Owen A thesis submitted for the degree of Doctor of Philosophy at the University of London September 2003 The Edward Jenner Institute for Vaccine Research University College London ProQuest Number: U642330 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. uest. ProQuest U642330 Published by ProQuest LLC(2015). Copyright of the Dissertation is held by the Author. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code. Microform Edition © ProQuest LLC. ProQuest LLC 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106-1346 Abstract Hepatitis C virus establishes a persistent infection in approximately 80% of infected individuals. It is unclear why the immune system is frequently unable to mediate a response capable of controlling HCV replication. Dendritic cells (DCs) may be an extrahepatic site of viral replication and it is hypothesised that expression of the core protein within DCs may impair their functions resulting in inadequate immune responses. To investigate potential immunomodulatory effects of the core protein on DCs, replication-deficient adenoviral vectors co-expressing different versions of the core protein (full-length, truncated and a version lacking residues 125-144) with GFP were constructed. Whilst these adenoviruses were being generated, experiments were carried out with an adenoviral vector expressing all the HCV structural proteins (Ad- CE1E2).
'Astrazeneca' Covid-19 Vaccine

Medicines Law & Policy How the ‘Oxford’ Covid-19 vaccine became the ‘AstraZeneca’ Covid-19 vaccine By Christopher Garrison 1. Introduction. The ‘Oxford / AstraZeneca’ vaccine is one of the world’s leading hopes in the race to end the Covid-19 pandemic. Its history is not as clear, though, as it may first seem. The media reporting about the vaccine tends to focus either on the very small (non-profit, academic) Jenner Institute at Oxford University, where the vaccine was first invented, or the very large (‘Big Pharma’ firm) AstraZeneca, which is now responsible for organising its (non-profit) world-wide development, manufacture and distribution. However, examining the intellectual property (IP) path of the vaccine from invention to manufacture and distribution reveals a more complex picture that involves other important actors (with for-profit perspectives). Mindful of the very large sums of public money being used to support Covid-19 vaccine development, section 2 of this note will therefore contextualise the respective roles of the Jenner Institute, AstraZeneca and these other actors, so that their share of risk and (potential) reward in the project can be better understood. Section 3 provides comments as well as raising some important questions about what might yet be done better and what lessons can be learned for the future. 2. History of the ‘Oxford / AstraZeneca’ vaccine. 2.1 Oxford University and Oxford University Innovation Ltd. The Bayh-Dole Act (1980) was hugely influential in the United States and elsewhere in encouraging universities to commercially exploit the IP they were generating by setting up ‘technology transfer’ offices.
Job Description and Person Specificationselection Criteria

Job title Senior Postdoctoral Scientist Division Medical Sciences Department Nuffield Department of Medicine, Jenner Institute Clinical Centre for Vaccinology and Translational Medicine Location (CCVTM), Old Road Campus, Headington, Oxford, OX3 7LE Grade 8: £41,526 - £49,553 per annum with a discretionary range Grade and salary to £54,131 per annum Hours Full time Contract type Fixed-term contract for 20 months, in the first instance Reporting to Professor Christine Rollier & Professor Cal MacLennan Vacancy reference 147960 Additional Position funded by US funding information Development of a Gonococcal Outer Membrane Vesicle Vaccine Research topic from Lead Optimization to Phase 1 Clinical Trial Principal Investigator Professor Christine Rollier & Professor Cal MacLennan / supervisor Project team Gonococcal Vaccine Group http://www.jenner.ac.uk/ Project web site Funding partner US funding 1. Gottlieb SL, et al. Gonococcal vaccines: public health value and preferred product characteristics; report of a WHO global stakeholder consultation, January 2019. Vaccine 2020; 38: 4362-4373. 2. Micoli, F et al. Comparative immunogenicity and efficacy of equivalent outer membrane vesicle and glycoconjugate vaccines against nontyphoidal Salmonella. PNAS 2018; Recent publications 115: 10428-33. 3. Folegatti PM, et al. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. Lancet 2020; 396: 467-478. 4. Marsay L, et al. A novel meningococcal outer membrane vesicle vaccine with constitutive expression of FetA: A phase I clinical trial. J Infect 2015; 71: 326-37. The Role The Gonococcal Vaccine Project is based at the Jenner Institute, University of Oxford, and utilizes a novel outer membrane vesicle (OMV) technology to develop a vaccine against gonorrhoea.
Job Description and Person Specification

Job description and selection criteria Job title Statistician (for Biomedical Informatics) Division Medical Sciences The George Institute for Global Health / Nuffield Department Department of Population Health New Richards Building, Old Road Campus, Location Headington, Oxford Grade and salary Grade 7: £29,541 - £36,298 Hours Full-time or part-time (at least 50%) Contract type Fixed-term, 18 months Reporting to Dr Kazem Rahimi Vacancy 111004 reference Introduction The University The University of Oxford is a complex and stimulating organisation, which enjoys an international reputation as a world-class centre of excellence in research and teaching. It employs over 10,000 staff and has a student population of over 22,000. Most staff are directly appointed and managed by one of the University’s 130 departments or other units within a highly devolved operational structure - this includes over 6,500 ‘academic-related’ staff (postgraduate research, computing, senior library, and administrative staff) and over 2,700 ‘support’ staff (including clerical, library, technical, and manual staff). There are also over 1,600 academic staff (professors, readers, lecturers), whose appointments are in the main overseen by a combination of broader divisional and local faculty board/departmental structures. Academics are generally all also employed by one of the 38 constituent colleges of the University as well as by the central University itself. Our annual income in 2011/12 was £1,016.1m. Oxford is one of Europe's most innovative and entrepreneurial universities: income from external research contracts exceeds £409m p.a., and more than 80 spin-off companies have been created. For more information please visit www.ox.ac.uk/staff/about_the_university.html The Medical Sciences Division The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching, and the largest academic division in the University of Oxford.
Graduate Prospectus 2012–13

Graduate Prospectus 2012–13 cover - separate file www.ox.ac.uk/graduate inside front cover - separate file Produced by © The University of The photographs used within University of Oxford this prospectus were submitted Do you need this prospectus Oxford 2011 by current graduate students Public Affairs Directorate and recent alumni as part of in another format? Distributed by All rights reserved. No part a photography competition University of Oxford of this publication may be that took place in 2011. All Braille, large print and audio formats Graduate Admissions reproduced, stored in a photographs are credited to are available on request from: and Funding retrieval system, or the photographer where they University Offices, transmitted, in any form appear. Graduate Admissions and Funding Wellington Square, or by any means, Oxford OX1 2JD electronic, mechanical, Cover photograph by Greg Smolonski Tel: +44 (0)1865 270059 photocopying, recording, +44 (0)1865 270059 Photograph by Michael Camilleri, or otherwise, without Email: [email protected] graduate.admissions@ MSc Computer Science prior permission. admin.ox.ac.uk (St Anne’s College) Graduate Prospectus 2012–13 | 3 Welcome to Oxford Our graduate students are vital to the University of Oxford. They form part of the academic research community, and the teaching and training they receive sets them up to join the next generation of leaders and innovators. Graduate study at Oxford is a very special experience. Our graduate students have the opportunity to work with leading academics, and the University has some of the best libraries, laboratories, museums and Rob Judges collections in the world.
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A Thesis Submitted for the Degree of PhD at the University of Warwick Permanent WRAP URL: http://wrap.warwick.ac.uk/149337 Copyright and reuse: This thesis is made available online and is protected by original copyright. Please scroll down to view the document itself. Please refer to the repository record for this item for information to help you to cite it. Our policy information is available from the repository home page. For more information, please contact the WRAP Team at: [email protected] warwick.ac.uk/lib-publications A Randomized Trial of Neprilysin Inhibition with Sacubitril/valsartan vs Irbesartan in Chronic Kidney Disease by Dr Parminder Kaur Judge Thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy (PhD) in Medicine University of Warwick & Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford Submitted June 2020 1 Contents Section Page List of Tables 7 List of Figures 9 Acknowledgements 10 Declarations 12 Inclusion of Published Work 13 Abstract 14 Chapters 1 List of abbreviations 15 2 Introduction 19 3 Natriuretic peptide system and neprilysin 35 2 4 Angiotensin receptor-neprilysin inhibitor (ARNI) 46 Effects on renal function 50 Effects on albuminuria 53 5 Methods 65 Trial organisation 70 Staff training 70 Data management 70 Trial treatments 70 Consent 72 Biological samples 73 Randomized treatment and blinding 76 Blood and urine samples 76 3 Adverse events and compliance with trial treatment 77 Physical measurements