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THE HUMAN MICROBIOME: Emerging Themes at the Horizon of the 21St Century

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THE HUMAN MICROBIOME: Emerging Themes at the Horizon of the 21St Century THE HUMAN MICROBIOME: Emerging Themes at the Horizon of the 21st Century August 16-18, 2017 • Natcher Conference Center, NIH PROGRAM BOOK *The workshop organizers would like to thank Ms. Maria G. Paez Segala ([email protected]) for invoking the spirit of Giuseppe Arcimboldo (http://www.giuseppe-arcimboldo.org/) to create ‘microbiome family’ for the Emerging Themes workshop program. TABLE OF CONTENTS Purpose and Goals and Acknowledgements ........................................................................................ 1 Agenda Social Media and Rules ........................................................................................................................... 3 Agenda .................................................................................................................................................... 5 Speaker Abstracts ............................................................................................................................ 15 Speaker Biosketches ........................................................................................................................ 39 Joint Agency Panel ........................................................................................................................... 57 Posters Social Media and Rules ......................................................................................................................... 59 Poster Titles and Numbers ................................................................................................................... 61 Poster Abstracts ................................................................................................................................... 69 Participants Speakers ............................................................................................................................................. 127 Poster Presenters ............................................................................................................................... 129 General Participants ........................................................................................................................... 135 Joint Agency Panel/Agency Representatives ..................................................................................... 151 Workshop Planning Committee ...................................................................................................... 153 Notes - i - - ii - PURPOSE AND GOALS This 2017 NIH-wide microbiome workshop was organized by a planning committee of the trans-NIH Microbiome Working Group (TMWG, https://commonfund.nih.gov/hmp/related_activities), which includes program staff from the 19 NIH Institutes, Centers, and Offices that support human microbiome research through their extramural portfolios. The TMWG is interested in taking stock of where the microbiome field stands after NIH’s 10-year investment in the Human Microbiome Project (https://commonfund.nih.gov/hmp) and evaluating what is needed for this field to advance over the next decade. This meeting will strive to cover advances that reveal the specific ways in which the microbiota influences the physiology of the host, in both a healthy and a diseased state, and how the microbiota may be manipulated, at either the community, population, organismal, or molecular level, to maintain and/or improve the health of the host. The goal of this workshop is to seek input from a trans- disciplinary group of scientists to identify (1) knowledge gaps, (2) technical hurdles, (3) new approaches, and (4) research opportunities which will inform the development of novel prevention and treatment strategies based on host/microbiome interactions over the next 10 years. The workshop closes with an Joint Agency Panel that includes the seven other government agencies which support human microbiome research activities human microbiome research activities to discuss areas of common interest and possible collaboration. ACKNOWLEDGMENTS The trans-NIH Microbiome Working Group 2017 “Emerging Themes” workshop planning committee would like to acknowledge the generous support of the following NIH Institutes, Centers, and Offices for this workshop: NCI, NHLBI, NIDCR, NIDDK, NIEHS, NIGMS, NINR, NCCIH, OAR/OD, ODS/OD, and ORWH/OD. In particular, we would like to thank the Office of Strategic Coordination, fondly known as The Common Fund, for providing generous monetary support, but also for hosting the workshop website and always expressing encouragement and enthusiasm for this workshop’s purpose and goals. - 1 - - 2 - SOCIAL MEDIA #ETmicrobiome Please ask the Presenter if their talk or poster can be live tweeted. Presenters, please let the audience know your choice. PHOTOGRAPHY/VIDEOCASTING Please ask the Presenter if their talk or poster can be photographed. Presenters, please let the audience know your choice. Presenters, please email the workshop organizers at [email protected] if you do not want your talk webcast. WORKSHOP URL https://commonfund.nih.gov/hmp/meetings/emerging Participants, monitor this website for updates to the program. WORKSHOP EMAIL [email protected] Participants, use this email to submit questions for the daily Round Tables and the Joint Agency Panel. - 3 - - 4 - AGENDA This conference is being recorded and will be available via live webcast at: The Human Microbiome: Emerging Themes at the Horizon of the 21st Century (Day 1) https://videocast.nih.gov/live.asp?live=24940 The Human Microbiome: Emerging Themes at the Horizon of the 21st Century (Day 2) https://videocast.nih.gov/live.asp?live=24944 The Human Microbiome: Emerging Themes at the Horizon of the 21st Century (Day 3) https://videocast.nih.gov/live.asp?live=24948 Day One: Wednesday, August 16, 2017 Theme of the Day: Overview and Approaches 9:00 a.m. Opening Session I. 9:00 a.m. – 9:15 a.m. Call to Order and Charge to the Moderator: Meeting Participants Lita Proctor National Human Genome Research Institute, NIH 9:15 a.m. – 10:00 a.m. Keynote I: What the Great Ape Howard Ochman Microbiome Can Tell Us About University of Texas at the Human Microbiome Austin 10:05 a.m. Theme Session I. The NIH Human Microbiome Project: Catalyst for an Emerging Field Session Purpose: Reflect on the resources, outcomes, and legacy of the 10-year HMP program. 10:05 a.m. – 10:10 a.m. Introduction to Session Moderator: Purpose Lita Proctor National Human Genome Research Institute, NIH 10:10 a.m. – 10:25 a.m. The NIH Human Microbiome Mary Ellen Perry Project: Overview of HMP Office of the Director, Program Goals and NIH Accomplishments 10:25 a.m. – 10:40 a.m. The Impact of the Microbiome Gregory A. Buck of the Female Reproductive Virginia Commonwealth Tract on Health and Pregnancy University 10:40 a.m. – 10:55 a.m. Integrative Personal Omics Michael P. Snyder Profiling During Periods of Stanford University Environmental Stress 10:55 a.m. – 11:10 a.m. Characterizing the Gut Curtis Huttenhower Microbial Ecosystem for T.H. Chan Harvard School Diagnosis and Therapy in of Public Health and Inflammatory Bowel Disease Broad Institute - 5 - Day One: Wednesday, August 16, 2017 11:10 a.m. – 11:25 a.m. Management and Integration Owen R. White of the iHMP Data University of Maryland 11:25 a.m. – 11:40 a.m. Joint QA Session 11:40 p.m. 11:40 a.m. – 1:00 p.m. Lunch and Poster Session 1:00 p.m. Theme Session II. State of the Art Microbiome Tools, Technologies, and Approaches #1: Beyond Sequencing Session Purpose: Highlight new tools/technologies for human microbiome research, what is appearing on the horizon, what other tools/technologies are needed, and what is needed to make progress in tool development for human microbiome research. 1:00 p.m. – 1:05 p.m. Introduction to Session Moderator: Purpose Lisa Chadwick National Institute of Environmental Health Sciences, NIH 1:05 p.m. – 1:20 p.m. Metagenotyping Reveals Katherine S. Pollard Cryptic Functional Variation in University of California, the Human Microbiome San Francisco 1:20 p.m. – 1:35 p.m. Moving Microbiome Studies Rob Knight Toward Causality With University of California, Temporal and Spatial San Diego Visualizations 1:35 p.m. – 1:50 p.m. The Need for Reproducible Pieter Dorrestein Global Chemical Analysis of the University of California, Microbiome by Mass San Diego Spectrometry 1:50 p.m. – 2:05 p.m. Systems Biology and Model- Elhanan Borenstein Based Analysis of the Human University of Washington Microbiome 2:05 p.m. – 2:20 p.m. Joint QA Session 2:25 p.m. Theme Session III. State of the Art Microbiome Tools, Technologies, and Approaches #2: Alternate Models Session Purpose: Highlight new and novel animal and nonanimal models for human microbiome research, what other kinds of models are needed, and what is needed to make progress in model development. 2:25 p.m. – 2:30 p.m. Introduction to Session Moderator: Purpose Dwayne Lunsford National Institute of Dental and Craniofacial Research, NIH 2:30 p.m. – 2:45 p.m. Minibioreactor Arrays to Probe Robert A. Britton the Functions of Complex Baylor College of Microbial Communities Medicine 2:45 p.m. – 3:00 p.m. The Drosophila Model for Gut Angela Douglas Microbiome Research Cornell University - 6 - Day One: Wednesday, August 16, 2017 3:00 p.m. – 3:15 p.m. Zebrafish as a Tractable Model John F. Rawls for Host-Microbiome Duke University Interactions 3:15 p.m. – 3:30 p.m. Swine as a Preclinical Model for Sharon M. Donovan Human Gut Microbiome University of Illinois Research 3:30 p.m. – 3:45 p.m. Spatiotemporal Metagenomics Harris H. Wang of the
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