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Cory Newman Thesis 5-2021 Signed.Pdf (1.303Mb)
DocuSign Envelope ID: 4851A328-CF63-4770-A833-B4246E7E5D23 Simulating Homonymous Hemianopsia for the Care Team by Cory Newman May 2021 Presented to the Division of Science, Information Arts, and Technologies University of Baltimore In Partial Fulfillment of the Requirements for the Degree of Master of Science 5/25/2021 Approved by: ________________________________ [name, Thesis Advisor] ________________________________5/25/2021 [name, Committee Member] i DocuSign Envelope ID: 4851A328-CF63-4770-A833-B4246E7E5D23 Abstract Homonymous hemianopsia is a visual impairment that involves the bilateral loss of a complete visual field. While research has been done to ascertain the details of cause and prognosis of homonymous hemianopsia, an obvious disparity arose in the research on how to educate the supporting care team of a person with homonymous hemianopsia to maximize the creation of educational and rehabilitation plans. This research presents two studies focused on closing that gap by providing an alternative method of understanding. In the initial study 16 participants with a confirmed caregiver relationship to one or more persons with homonymous hemianopsia were surveyed on their personal knowledge of the visual impairment. These participants were asked to express any visual obstacles they have encountered, and to ascertain the availability of a device or program that could provide an interactive interpretation of how their homonymous hemianopsia patient views their surroundings. Survey results confirmed the need for a program that could easily simulate homonymous hemianopsia for the care provider. An additional usability study was completed by eight of the 16 previous participants on a mobile homonymous hemianopsia simulation application prototype. User tests showed that participants gained a significant increase in understanding of how those with a homonymous hemianopsia visual impairment view the environment. -
(Kir) Channels in Tick Salivary Gland Function Zhilin Li Louisiana State University and Agricultural and Mechanical College, [email protected]
Louisiana State University LSU Digital Commons LSU Master's Theses Graduate School 3-26-2018 Characterizing the Physiological Role of Inward Rectifier Potassium (Kir) Channels in Tick Salivary Gland Function Zhilin Li Louisiana State University and Agricultural and Mechanical College, [email protected] Follow this and additional works at: https://digitalcommons.lsu.edu/gradschool_theses Part of the Entomology Commons Recommended Citation Li, Zhilin, "Characterizing the Physiological Role of Inward Rectifier Potassium (Kir) Channels in Tick Salivary Gland Function" (2018). LSU Master's Theses. 4638. https://digitalcommons.lsu.edu/gradschool_theses/4638 This Thesis is brought to you for free and open access by the Graduate School at LSU Digital Commons. It has been accepted for inclusion in LSU Master's Theses by an authorized graduate school editor of LSU Digital Commons. For more information, please contact [email protected]. CHARACTERIZING THE PHYSIOLOGICAL ROLE OF INWARD RECTIFIER POTASSIUM (KIR) CHANNELS IN TICK SALIVARY GLAND FUNCTION A Thesis Submitted to the Graduate Faculty of the Louisiana State University and Agricultural and Mechanical College in partial fulfillment of the requirements for the degree of Master of Science in The Department of Entomology by Zhilin Li B.S., Northwest A&F University, 2014 May 2018 Acknowledgements I would like to thank my family (Mom, Dad, Jialu and Runmo) for their support to my decision, so I can come to LSU and study for my degree. I would also thank Dr. Daniel Swale for offering me this awesome opportunity to step into toxicology filed, ask scientific questions and do fantastic research. I sincerely appreciate all the support and friendship from Dr. -
Homonymous Hemianopsia
Source: CLEVELAND CLINIC OHIO USA FACTSHEET Homonymous Hemianopsia Homonymous hemianopsia is a condition in which a person sees only one side - right or left of the visual world of each eye; results from a problem in brain function rather than a disorder of the eyes themselves. This can happen after a head or brain injury. What is homonymous hemianopsia? Homonymous hemianopsia is a condition in which a person sees only one side―right or left―of the visual world of each eye. The person may not be aware that the vision loss is happening in both eyes, not just one. Under normal circumstances, the left half of the brain processes visual information from both eyes about the right side of the world. The right side of the brain processes visual information from both eyes about the left side of the world. A visual world of someone with normal vision A visual world of someone with homonymous hemianopsia In homonymous hemianopsia, an injury to the left part of the brain results in the loss of the right half of the visual world of each eye. An injury to the right part of the brain produces loss of the left side of the visual world of each eye. This condition is created by a problem in brain function rather than a disorder of the eyes themselves. What causes homonymous hemianopsia? The most common cause of this type of vision loss is stroke. However, any disorder that affects the brain—including tumours, inflammation, and injuries--can be a cause. Source: CLEVELAND CLINIC OHIO USA It is estimated that 70% of the injuries leading to hemianopsias are due to an obstruction (blockage) of the blood supply (stroke). -
Neuroophthalmology
Neuroophthalmology MAREK MICHALEC, MD PHD Clinic of Ophthalmology Faculty Hospital Brno and Masaryk University Version 12/2019 Content • Visual pathway affection • Diseases and affections of optic nerve • Optic chiasm pathology • Pathology of retrochiasmic part • Eye movement disorders • Binocular diplopia • Pupillary reaction abnormalities • Anisocoria • Combined disorders Examination - part I • Medical history • subjective (visual loss, diplopia) • When it started/ how long lasts it? • Does it change in time/ during the day? • Any progression? • What about the fellow eye? • Other signs? • Personal medical history? • Pharmacological history? • objective (pupillary dysfunction, eye movement disorders, ptosis of upper eyelid, red eye) Examination - part II • Visual acuity • Without and with correction • Monocular vision / binocular vision • Basic ophthalmological examination • Anterior segment (by slit lamp) • Posterior segment - arteficial mydriasis is essential (indirect ophthalmoscopy) • Visual field examination (static / kinetic perimetry) Examination - part III • Basic examination (GP) • Neurological examination • Intracranial conditions (including MRI) • neurological signs • Endocrinology • Thyroid associated orbitopathy / ophthalmopathy • Pituitary dysfunction Examination - part IV • Imaging techniques • Ultrasonography (eye bulb, orbit) • X-ray of skull (orbit, paranasal cavities) • Computerised Tomography of head (brain, skull bones, orbital bones) • MRI of head (brain, orbital structures) Optic nerve disorders Clinical signs • -
Oct Institute
Low Vision, Visual Dysfunction and TBI – Treatment, Considerations, Adaptations Andrea Hubbard, OTD, OTR/L, LDE Objectives • In this course, participants will: 1. Learn about interventions involving specialized equipment to adapt an environment for clients with low vision. 2. Learn about the most typical low vision presentations/conditions. 3. Gain increased knowledge of eye anatomy and the visual pathway. Overview of TBI Reference: Centers for Disease Control and Prevention Overview of TBI Risk Factors for TBI Among non-fatal TBI-related injuries for 2006–2010: • Men had higher rates of TBI hospitalizations and ED visits than women. • Hospitalization rates were highest among persons aged 65 years and older. • Rates of ED visits were highest for children aged 0-4 years. • Falls were the leading cause of TBI-related ED visits for all but one age group. – Assaults were the leading cause of TBI-related ED visits for persons 15 to 24 years of age. • The leading cause of TBI-related hospitalizations varied by age: – Falls were the leading cause among children ages 0-14 and adults 45 years and older. – Motor vehicle crashes were the leading cause of hospitalizations for adolescents and persons ages 15-44 years. Reference: Centers for Disease Control and Prevention Overview of TBI Risk Factors for TBI Among TBI-related deaths in 2006–2010: • Men were nearly three times as likely to die as women. • Rates were highest for persons 65 years and older. • The leading cause of TBI-related death varied by age. – Falls were the leading cause of death for persons 65 years or older. -
Ministry of Public Health of Ukraine Ukrainian Medical Stomatological Academy
Ministry of Public Health of Ukraine Ukrainian Medical Stomatological Academy Approved At the meeting of the department of neurological diseases with neurosurgery and medical genetic "__"__ ____________20___ Protocol №________ Head of department _______________ prof. Delva M.Yu. METHODICAL INSTRUCTIONS FOR THE INDEPENDENT WORK OF STUDENTS FOR PREPARATION TO PRACTICAL CLASSES AND DURING PRACTICAL CLASSES Academic subject Neurology The module № 1 General neurology Topic Syndromes of defeat oculomotor nerves. Pathology of olfactory and visual analyzers. Year of study IV Faculty Foreign Students Training (Medicine) Poltava 20___ 1.Relevance of the topic: the olfactory and visual analyzers play a role in receptor function of the nervous system. With the functions of these disorders analyzers, as well as with oculomotor disturbances faced by doctors of different specialties - neurologists, ophthalmologists, neurosurgeons, pediatricians, phthisiatricians, endocrinologists, internists. Violations of the functions of these analyzers is observed in a variety of inflammatory, demyelinating processes, tumors, trauma, endocrine disorders. The correct methodological approach to the study of functions, pathological changes of the olfactory and visual analyzers, oculomotor nerves makes it possible to deliver topical and clinical diagnosis and treatment in a timely manner. 2. Specific Objectives: To investigate the function of I, II, III, IV, VI pairs of cranial nerves, identify signs of a lesion of the nerve disorder Examine the identification functions -
Scienti®C Review Spastic Movement Disorder
Spinal Cord (2000) 38, 389 ± 393 ã 2000 International Medical Society of Paraplegia All rights reserved 1362 ± 4393/00 $15.00 www.nature.com/sc Scienti®c Review Spastic movement disorder V Dietz*,1 1Paracare, Paraplegic Centre of the University Hospital Balgrist, ZuÈrich, Switzerland This review deals with the neuronal mechanisms underlying spastic movement disorder, assessed by electrophysiological means with the aim of ®rst, a better understanding of the underlying pathophysiology and second, the selection of an adequate treatment. For the patient usually one of the ®rst symptoms of a lesion within the central motor system represents the movement disorder, which is most characteristic during locomotion in patients with spasticity. The clinical examination reveals exaggerated tendon tap re¯exes and increased muscle tone typical of the spastic movement disorder. However, today we know that there exists only a weak relationship between the physical signs obtained during the clinical examination in a passive motor condition and the impaired neuronal mechanisms being in operation during an active movement. By the recording and analysis of electrophysiological and biomechanical parameters during a functional movement such as locomotion, the signi®cance of, for example, impaired re¯ex behaviour or pathophysiology of muscle tone and its contribution to the movement disorder can reliably be assessed. Consequently, an adequate treatment should not be restricted to the cosmetic therapy and correction of an isolated clinical parameter but should be based on the pathophysiology and signi®cance of the mechanisms underlying the disorder of functional movement which impairs the patient. Spinal Cord (2000) 38, 389 ± 393 Keywords: spinal cord injury; spasticity; electrophysiological recordings; treatment Introduction Movement disorders are prominent features of impaired strength of electromyographic (EMG) activation of function of the motor systems and are frequently best antagonistic leg muscles as well as intrinsic and passive re¯ected during gait. -
Toxicological Testing in Large Animals
Toxicological Testing in Large Animals Toxic causes of ill health and death in production animals are numerous. Toxin testing requires a specific toxin to be nominated as there is no suite of tests that covers all possibilities. Toxin testing is inherently expensive, requires specific sample types and false negatives can occur; for instance the toxin may have been eliminated from the body or be undetectable, but clinical signs may persist. Gribbles Veterinary Pathology can offer specific testing for a range of toxic substances, however it is important to consider the specific sample requirements and testing limitations for each toxin when advising your clients. Many tests are referred to external laboratories and may have extended turnaround times. Please contact the laboratory if you need testing for a specific toxin not listed here; we can often source unusual tests as needed from our network of referral laboratories. Clinicians should also consider syndromes which may mimic intoxication such as hypocalcaemia, hypoglycaemia, hepatic encephalopathy, peripheral neuropathies and primary CNS diseases. Examples of intoxicants that can be tested are provided below. See individual tests in the Pricelist for sample requirements and costs. Biological control agents Heavy metals • 1080 (fluoroacetate) • Arsenic • Strychnine • Lead • Synthetic pyrethroids • Copper • Organophosphates • Selenium • Organochlorines • Zinc • Carbamates • Metaldehyde • Anticoagulant rodenticides (warfarin, pindone, coumetetryl, bromadiolone, difenacoum, brodifacoum) -
Clinical Neurophysiology Board Review Q&A
Clinical Neurophysiology Board Review Board Clinical Neurophysiology Clinical Neurophysiology Board Review Q&A Clinical Puneet K. Gupta, MD, MSE • Pradeep N. Modur, MD, MS • Srikanth Muppidi, MD his high-yield, illustrated clinical neurophysiology board review is a comprehen- Neurophysiology sive resource for assessing and refining the knowledge tested on multiple board Texaminations. Written by authors who are collectively board certified in all of the areas covered, the book is a valuable study tool for candidates preparing for certifica- tion or recertification in clinical neurophysiology, neuromuscular medicine, epilepsy, Board Review sleep medicine, and neurology. Using structured question formats typically encountered on boards, this comprehensive review allows users to assess their knowledge in a wide range of topics, provides rationales for correct answers, and explains why the other choices are incorrect. A unique “Pearls” section at the end of the book allows for quick review of the most important concepts prior to exam day. Clinical Neurophysiology Board Review Q&A contains 801 questions with answers and detailed explanations. The book is divided into eight chapters covering anatomy Q and physiology, electronics and instrumentation, nerve conduction studies and EMG, & EEG, evoked potentials and intraoperative monitoring, sleep studies, ethics and safety, and advanced topics including QEEG, MEG, TES, autonomic testing, and more. A Liberal use of image-based questions illustrating the full spectrum of neurophysiologic & tests and findings build interpretive skills. Questions are randomized and include Q A both case-related questions in series and stand-alone items to familiarize candidates Gu with the question types and formats they will find on the exam. -
TWITCH, JERK Or SPASM Movement Disorders Seen in Family Practice
TWITCH, JERK or SPASM Movement Disorders Seen in Family Practice J. Antonelle de Marcaida, M.D. Medical Director Chase Family Movement Disorders Center Hartford HealthCare Ayer Neuroscience Institute DEFINITION OF TERMS • Movement Disorders – neurological syndromes in which there is either an excess of movement or a paucity of voluntary and automatic movements, unrelated to weakness or spasticity • Hyperkinesias – excess of movements • Dyskinesias – unnatural movements • Abnormal Involuntary Movements – non-suppressible or only partially suppressible • Hypokinesia – decreased amplitude of movement • Bradykinesia – slowness of movement • Akinesia – loss of movement CLASSES OF MOVEMENTS • Automatic movements – learned motor behaviors performed without conscious effort, e.g. walking, speaking, swinging of arms while walking • Voluntary movements – intentional (planned or self-initiated) or externally triggered (in response to external stimulus, e.g. turn head toward loud noise, withdraw hand from hot stove) • Semi-voluntary/“unvoluntary” – induced by inner sensory stimulus (e.g. need to stretch body part or scratch an itch) or by an unwanted feeling or compulsion (e.g. compulsive touching, restless legs syndrome) • Involuntary movements – often non-suppressible (hemifacial spasms, myoclonus) or only partially suppressible (tremors, chorea, tics) HYPERKINESIAS: major categories • CHOREA • DYSTONIA • MYOCLONUS • TICS • TREMORS HYPERKINESIAS: subtypes Abdominal dyskinesias Jumpy stumps Akathisic movements Moving toes/fingers Asynergia/ataxia -
The Peripheral Nerves: Update on Ultrasound and Magnetic Resonance Imaging I
The peripheral nerves: update on ultrasound and magnetic resonance imaging I. Möller1, M. Miguel2, D.A. Bong1, F. Zaottini3, C. Martinoli4 1Instituto Poal de Reumatologia, ABSTRACT of the nerve along its trajectory along University of Barcelona, Spain, The motor and sensory branches of with immediate one-to-one compari- and EULAR Working Group Anatomy the somatic peripheral nervous system son with the contralateral structures (6, for the Image; (PNS) can be visualised by different im- 7). In addition, US-guidance has led to 2Department of Pathology and Experimental Therapeutics, Human aging systems. This article focuses on the development of a variety of inter- Anatomy and Embryology Unit, imaging of peripheral nerves by mag- ventional procedures. The use of US is University of Barcelona, Spain; netic resonance imaging (MRI) and becoming widespread in providing ac- 3Department of Health Sciences, high-resolution ultrasound (US). The curate and safe regional anesthesia as DISSAL, University of Genoa; anatomic basis of the peripheral nerve well as focal and regional pain manage- 4 Department of Health Science, image, common pathologies and clini- ment. It has also becoming an increas- University of Genoa, Ospedale cal value of US and MRI imaging of pe- ingly important component of muscu- Policlinico San Martino, Genoa, Italy. ripheral nerves are reviewed. loskeletal specialties such as physical Ingrid Möller, MD medicine and rehabilitation and sports Maribel Miguel, MD David A. Bong, MD Introduction medicine. Federico Zaottini, MD Nerve pathology may be a cause of Carlo Martinoli, MD chronic pain and disability. The initial Anatomical considerations Please address correspondence to: diagnostic evaluation of the periph- The PNS includes spinal nerves that Dr David A. -
Nonnekes Gait Upper Motor Neuron Syndrome Clean
A review of the management of gait impairments in chronic unilateral upper motor neuron lesions Jorik Nonnekes MD PhD1, 2, Nathalie Benda MD PhD2, Hanneke van Duijnhoven MD1, Frits Lem MD2, Noël Keijsers PhD3, Jan Willem K. Louwerens MD PhD4, Allan Pieterse PT PhD1, Bertjo Renzenbrink MD,5 Vivian Weerdesteyn PT PhD,1,3 Jaap Buurke PT PhD,6,7 Alexander C.H. Geurts MD PhD1,2 1Department of Rehabilitation, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands; 2Department of Rehabilitation, Sint Maartenskliniek, Nijmegen, The Netherlands 3Research Department, Sint Maartenskliniek, Nijmegen, The Netherlands 4Department of Orthopaedics, Sint Maartenskliniek, Nijmegen, The Netherlands 5Rijndam Rehabilitation Center, Rotterdam, The Netherlands 6Roessingh Research and Development, Enschede, the Netherlands 7Biomedical Signals and Systems, MIRA - Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands Running title: Gait impairments in supratentorial upper motor neuron syndromes Word count: 3497 Corresponding author Jorik Nonnekes, MD, PhD Radboud University Medical Centre Department of Rehabilitation PO Box 19101, 6500 HB Nijmegen The Netherlands E-mail: [email protected] ABSTRACT Importance: A variety of neurological disorders can damage the corticospinal tract in the supratentorial region of the brain. Gait impairments are common in patients with chronic supratentorial upper motor neuron lesions, and are a source of great disability. Clinical management aimed at improving the gait pattern in these patients is generally perceived as a challenging task, as many possible abnormalities may interact. Moreover, a multitude of treatment options exist – ranging from assistive devices and muscle stretching to pharmacological and surgical interventions – but evidence is inconclusive for most approaches and there is a lack of clear treatment guidelines.