DOCSLIB.ORG

Problems of Drug Dependence 1982 Proceedings of the 44Th Annual Scientific Meeting The

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

National Institute Drug Abuse MONOGRAPH SERIES Problems of Drug Dependence 1982 Proceedings of the 44th Annual Scientific Meeting The Committee on Problems of Drug Dependence, Inc. U. S. DEPARTMENT OF HEALTH AND HUMAN SERVICE • Public Health Service • Alcohol, Drug Abuse, and Mental Health Administration Problems of Drug Dependence, 1982 Proceedings of the 44th Annual Scientific Meeting, The Committee on Problems of Drug Dependence, Inc. Editor, Louis S. Harris, Ph.D. NIDA Research Monograph 43 April 1983 DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Alcohol, Drug Abuse, and Mental Health Administration National Institute on Drug Abuse Office of Science 5600 Fishers Lane Rockville, Maryland 20657 NIDA Research Monographs are prepared by the research divisions of the National Institute on Drug Abuse and published by its Office of Science. The primary objective of the series is to provide critical reviews of research problem areas and techniques, the content of state-of-the-art confer- ences, integrative research reviews and significant original research. Its dual publication emphasis is rapid and targeted dissemination to the scientific and professional community. Editorial Advisory Board Avram Goldstein, M.D. Addiction Research Foundation Palo Alto, California Jerome Jaffe, M.D. University of Connecticut School of Medicine Farmington, Connecticut Reese T. Jones, M.D. Langley Porter Neuropsychiatric Institute University of California San Francisco, California Jack Mendelson, M.D. Alcohol and Drug Abuse Research Center Harvard Medical School McLean Hospital Belmont, Massachusetts Helen Nowlis, Ph.D. Rochester, New York Lee Robins, Ph.D. Washington University School of Medicine St. Louis, Missouri NIDA Research Monograph Series William Pollin, M.D. DIRECTOR, NIDA Jack Dwell, M.D. ASSOCIATE DIRECTOR, OFFICE OF SCIENCE, NIDA EDITOR-IN-CHIEF Eleanor W. Waldrop MANAGING EDITOR Parklawn Building, 5600 Fishers Lane, Rockville, Maryland 20857 For sale by the Superintendent of Documents, U.S. Government Printing Office Washington, D.C. 20402 Problems of Drug Dependence, 1982 Proceedings of the 44th Annual Scientific Meeting, The Committee on Problems of Drug Dependence, Inc. MEMBERS, COMMITTEE ON PROBLEMS OF DRUG DEPENDENCE, INC. Dr. Joseph Brady, Chairman Dr. Martin Adler Dr. Sidney Archer Dr. William Beaver Dr. Richard Bonnie Dr. Theodore Cicero Dr. Troy Duster Dr. Charles Gorodetzky Dr. Theresa Harwood Dr. Leo Hollister Dr. Jerome Jaffe Dr. Harold Kalant Dr. Charles O'Brien Dr. C. R. Schuster, Jr. Dr. Henry Swain EXECUTIVE SECRETARY Dr. Joseph Cochin MEMBERS, BOARD OF DIRECTORS Dr. E. L. Way, Chairman Am. Soc. Pharmacol. Exptl. Ther. Dr. Raymond W. Houde Am. Soc. Clin. Pharmacol. Ther. Dr. Keith F. Killam Am. Coll. Neuropsychopharmacol. Dr. Everette May Am. Chemical Society Dr. Jack Mendelson Am. Psychiatric Assn. Dr. Beny J. Primm Natl. Medical Assn. Dr. Lee N. Robins Am. Sociological Assn. Dr. Edward C. Senay Am. Medical Assn. Dr. James Woods Am. Psychological Assn. PERMANENT LIAISON Dr. Louis S. Harris Dr. Arthur Jacobson MEMBERS, PROGRAM COMMITTEE Dr. Louis S. Harris, Chairman Dr. Everette L. May Mrs. Joyce H. Pye MEMBERS, COMMITTEE ON ARRANGEMENTS Dr. Harold Kalant Dr. William Gilliland CONTRIBUTING FIRMS, 1981-82 The following firms have supported the work of the Committee on Problems of Drug Dependence, Inc. through contributions during the previous fiscal year. Abbott Laboratories Ayerst of Canada Boehringer Ingelheim International Bristol Laboratories Burroughs Wellcome Co. CIBA-GEIGY Clin-Midy of America, Inc. Dupont Glaxo Hoechst-Roussel Pharmaceuticals, Inc. Hoffmann-La Roche Inc. ICI Americas Inc. Johnson & Johnson Knoll Pharmaceutical Company Lederle Laboratories (Cyanamid) Lilly Research Laboratories McNeil Pharmaceutical Merck Sharp & Dohme Research Labs Ortho Pharmaceutical Corporation Pennwalt Corporation Pharmaceutical Div. Pfizer Central Research Reckitt & Colman Pharmaceutical Div. Schering Searle Research & Development SISA Incorporated Smith, Kline & French Laboratories Sterling Drug Inc. Syntex The Upjohn Company USV Pharmaceutical Corp. (Revlon) Wyeth Laboratories Zambon ACKNOWLEDGENT The papers in this monograph were presented or read by title at the 44th Annual Scientific Meeting of the Committee on Problems of Drug Dependence, Inc., in Toronto, Ontario, Canada, on June 27- 30, 1982. Louis S. Harris, Ph.D., who edited the monograph, is Chairman, Department of Pharmacology, Medical College of Virginia, Richmond, Virginia. Opinions expressed in the papers are those of the authors and do not necessarily reflect the opinions or official policy of the National Institute on Drug Abuse or any other part of the Department of Health and Human Services. The United States Government does not endorse or favor any specific commercial product or commodity. Trade or proprietary names appearing in this publication are used only because they are considered essential in the context of the studies reported herein. COPYRIGHT STATUS The table at the bottom of page 33 is copyrighted by the Journal of Studies on Alcohol, Inc., New Brunswick, NJ 08903, and is reproduced with their permission. Its further reproduction with- out specific permission of the copyright holder is prohibited. The table at the top of page 31 is adapted from material copy- righted by the Journal of Studies on Alcohol, Inc., and the table on page 173 is adapted from material copyrighted by Plenum Press, New York, NY 10013. They are used here by permission of the copyright holders. Before reprinting, readers are advised to determine their copyright status or to secure permission of the copyright holders. All other material except quoted passages from copyrighted sources is in the public domain and may be reproduced without permission. Citation as to source is appreciated. Library of Congress catalog card number 83-600528 DHHS publication number (ADM) 83-1264 Printed 1983 NIDA Research Monographs are indexed in the Index Medicus. They are selectively included in the coverage of the American Statistics Index, BioSciences Information Service, Chemical Abstracts, Current Contents, Psychological Abstracts, and Psychopharmacology Abstracts. v Foreword The Proceedings of each Annual Scientific Meeting of the Committee on Problems of Drug Dependence (CPDD) comprise a kind of contour map of one year’s explorations and advances along the frontiers of our knowledge about drug abuse. The remarkably broad range of research interests among the membership of the CPDD is reflected in the record of its meetings and the expertise of its membership, which includes biochemists and pharmacologists, physicians, sociologists, psychologists and other public health professionals. The proceedings of its annual meeting enable the reader to consider the vast scientific territory of recent research advances in substance abuse in a single volume. For that reason, the National Institute on Drug Abuse is once again pleased to publish the CPDD proceedings in its Research Monograph series. As in past years this volume contains a variety of timely papers and progress reports on ongoing investigations in the field as well as the annual report of the CPDD Drug Testing Program which evaluates the efficacy and dependence liability of new compounds. Several of the papers from the 44th Annual Scientific Meeting, held in Toronto on June 27-30, 1982, present Canadian perspectives on issues of common concern. Approximately half of the projects discussed are fully or partially supported by NIDA but much work is also underwritten by our sister Institutes in ADAMHA, by other Federal agencies, by State governments, by the governments of other countries, and by private industry. A most important contribution of the CPDD is its linking of the efforts of all of these groups to enlarge our understanding of psychoactive substances and their effects on human health and behaviors. This should help lead toward more effective prevention and treatment of the serious public health consequences of drug abuse. William Pollin, M.D. Director National Institute on Drug Abuse vii Contents Foreword William Pollin vii Plenary Session The J. Michael Morrison Award, 1982 Robert C. Petersen 1 Pharmacological Treatment of Narcotic Addiction (The Eighth Nathan B. Eddy Memorial Award Lecture) Vincent P. Dole and Marie E. Nyswander 5 Chemical Dependence in Canada: A View From the Hill Ian W. D. Herderson 10 Cultural Aspects of Alcohol and Drug Problems in Canada Juan Carlos Negrete 21 The Addiction Research Foundation-Mandate, Role, and Directions Joan A. Marshman 36 Symposium: Advances in Treatment of Drug Dependence Recent Advances in Opiate Detoxification: Clonidine and Lofexidine Arnold M. Washton and Richard B. Resnick 44 Methadone Maintenance: An Update Edward C. Senay 51 Psychotherapy for Opiate Addicts George E. Woody, Lester Luborsky, A. Thomas McLellan, Charles P. O’Brien, Aaron T. Beck, Jack Blaine, Ira Herman, and Anita Hole 59 ix Opioid Antagonists: Do They Have a Role in Treatment Programs? Charles P. O’Brien, Robert A. Greenstein, Bradley Evans, George E. Woody, and Robin Arndt 71 Annual Reports Progress Report: Medical College of Virginia--Sigma Agonists L. S. Harris, M. D. Aceto, R. L. Balster, and B. R. Martin 79 Progress Report from the NIDA Addiction Research Center (Preclinical Laboratory), Lexington, Kentucky C. W. Gorodetzky , E. J. Cone, S. R. Goldberg, S. Herling, M. E. Risner, H. E. Shannon, and D. B. Vaupel 85 Progress Report of the NIDA Addiction Research Center, Baltimore, Marylard
Recommended publications
  • Antinociceptive Effects of Monoamine Reuptake Inhibitors in Assays of Pain-Stimulated and Pain-Depressed Behaviors

    Antinociceptive Effects of Monoamine Reuptake Inhibitors in Assays of Pain-Stimulated and Pain-Depressed Behaviors

    Virginia Commonwealth University VCU Scholars Compass Theses and Dissertations Graduate School 2012 Antinociceptive Effects of Monoamine Reuptake Inhibitors in Assays of Pain-Stimulated and Pain-Depressed Behaviors Marisa Rosenberg Virginia Commonwealth University Follow this and additional works at: https://scholarscompass.vcu.edu/etd Part of the Medical Pharmacology Commons © The Author Downloaded from https://scholarscompass.vcu.edu/etd/2715 This Thesis is brought to you for free and open access by the Graduate School at VCU Scholars Compass. It has been accepted for inclusion in Theses and Dissertations by an authorized administrator of VCU Scholars Compass. For more information, please contact [email protected]. ANTINOCICEPTIVE EFFECTS OF MONOAMINE REUPTAKE INHIBITORS IN ASSAYS OF PAIN-STIMULATED AND PAIN-DEPRESSED BEHAVIOR A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University By Marisa B. Rosenberg Bachelor of Science, Temple University, 2008 Advisor: Sidney Stevens Negus, Ph.D. Professor, Department of Pharmacology/Toxicology Virginia Commonwealth University Richmond, VA May, 2012 Acknowledgement First and foremost, I’d like to thank my advisor Dr. Steven Negus, whose unwavering support, guidance and patience throughout my graduate career has helped me become the scientist I am today. His dedication to education, learning and the scientific process has instilled in me a quest for knowledge that I will continue to pursue in life. His thoroughness, attention to detail and understanding of pharmacology has been exemplary to a young person like me just starting out in the field of science. I’d also like to thank all of my committee members (Drs.
  • FSI-D-16-00226R1 Title

    FSI-D-16-00226R1 Title

    Elsevier Editorial System(tm) for Forensic Science International Manuscript Draft Manuscript Number: FSI-D-16-00226R1 Title: An overview of Emerging and New Psychoactive Substances in the United Kingdom Article Type: Review Article Keywords: New Psychoactive Substances Psychostimulants Lefetamine Hallucinogens LSD Derivatives Benzodiazepines Corresponding Author: Prof. Simon Gibbons, Corresponding Author's Institution: UCL School of Pharmacy First Author: Simon Gibbons Order of Authors: Simon Gibbons; Shruti Beharry Abstract: The purpose of this review is to identify emerging or new psychoactive substances (NPS) by undertaking an online survey of the UK NPS market and to gather any data from online drug fora and published literature. Drugs from four main classes of NPS were identified: psychostimulants, dissociative anaesthetics, hallucinogens (phenylalkylamine-based and lysergamide-based materials) and finally benzodiazepines. For inclusion in the review the 'user reviews' on drugs fora were selected based on whether or not the particular NPS of interest was used alone or in combination. NPS that were use alone were considered. Each of the classes contained drugs that are modelled on existing illegal materials and are now covered by the UK New Psychoactive Substances Bill in 2016. Suggested Reviewers: Title Page (with authors and addresses) An overview of Emerging and New Psychoactive Substances in the United Kingdom Shruti Beharry and Simon Gibbons1 Research Department of Pharmaceutical and Biological Chemistry UCL School of Pharmacy
  • Title 21 Food and Drugs Part 1300 to End

    Title 21 Food and Drugs Part 1300 to End

    Title 21 Food and Drugs Part 1300 to End Revised as of April 1, 2011 Containing a codification of documents of general applicability and future effect As of April 1, 2011 Published by the Office of the Federal Register National Archives and Records Administration as a Special Edition of the Federal Register VerDate Mar<15>2010 07:57 May 04, 2011 Jkt 223073 PO 00000 Frm 00001 Fmt 8091 Sfmt 8091 Y:\SGML\223073.XXX 223073 erowe on DSK5CLS3C1PROD with CFR U.S. GOVERNMENT OFFICIAL EDITION NOTICE Legal Status and Use of Seals and Logos The seal of the National Archives and Records Administration (NARA) authenticates the Code of Federal Regulations (CFR) as the official codification of Federal regulations established under the Federal Register Act. Under the provisions of 44 U.S.C. 1507, the contents of the CFR, a special edition of the Federal Register, shall be judicially noticed. The CFR is prima facie evidence of the origi- nal documents published in the Federal Register (44 U.S.C. 1510). It is prohibited to use NARA’s official seal and the stylized Code of Federal Regulations logo on any republication of this material without the express, written permission of the Archivist of the United States or the Archivist’s designee. Any person using NARA’s official seals and logos in a manner inconsistent with the provisions of 36 CFR part 1200 is subject to the penalties specified in 18 U.S.C. 506, 701, and 1017. Use of ISBN Prefix This is the Official U.S. Government edition of this publication and is herein identified to certify its authenticity.
  • Poisons and Narcotic Drugs (Amendment) Ordinance 1988

    Poisons and Narcotic Drugs (Amendment) Ordinance 1988

    AUSTRALIAN CAPITAL TERRITORY Poisons and Narcotic Drugs (Amendment) Ordinance 1988 No. 96 of 1988 I, THE GOVERNOR-GENERAL of the Commonwealth of Australia, acting with the advice of the Federal Executive Council, hereby make the following Ordinance under the Seat of Government (Administration) Act 1910. Dated 15 December 1988 N. M. STEPHEN Governor-General By His Excellency’s Command, CLYDE HOLDING Minister of State for the Arts and Territories An Ordinance to amend the Poisons and Narcotic Drugs Ordinance 1978 Short title 1. This Ordinance may be cited as the Poisons and Narcotic Drugs (Amendment) Ordinance 1988.1 Commencement 2. This Ordinance commences on such date as is fixed by the Minister by notice in the Gazette. Principal Ordinance 3. In this Ordinance, “Principal Ordinance” means the Poisons and Narcotic Drugs Ordinance 1978.2 (Ord. 79/88)—Cat. No. Authorised by the ACT Parliamentary Counsel—also accessible at www.legislation.act.gov.au 2 Poisons and Narcotic Drugs (Amendment) No. 96, 1988 Substances to which Division applies 4. Section 27B of the Principal Ordinance is amended by adding at the end the following paragraphs: “; (f) follicle stimulating hormone; (g) luteinising hormone; (h) thalidomide.”. Grant of authorisation 5. Section 27E of the Principal Ordinance is amended— (a) by omitting from paragraph (1) (a) “or cyclofenil” and substituting “, cyclofenil, follicle stimulating hormone or luteinising hormone”; (b) by omitting from paragraph (1) (b) “and”; and (c) by adding at the end of subsection (1) the following word and paragraph: “; and (d) in the case of an application that relates to thalidomide— the applicant is a specialist physician with no less than 5 years’ experience in the treatment of erythema nodosum leprosum.”.
  • Acute Toxicity Associated with the Recreational Use of the Novel Dissociative Psychoactive Substance Methoxphenidine

    Acute Toxicity Associated with the Recreational Use of the Novel Dissociative Psychoactive Substance Methoxphenidine

    Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2014 Acute toxicity associated with the recreational use of the novel dissociative psychoactive substance methoxphenidine Hofer, K E ; Degrandi, C ; Müller, D M ; Zürrer-Härdi, U ; Wahl, S ; Rauber-Lüthy, C ; Ceschi, A Abstract: INTRODUCTION: Methoxphenidine is a novel dissociative designer drug of the diarylethy- lamine class which shares structural features with phencyclidine (PCP), and is not at present subject to restrictive regulations. There is very limited information about the acute toxicity profile of methoxpheni- dine and the only sources are anonymous internet sites and a 1989 patent of the Searle Company. We report a case of analytically confirmed oral methoxphenidine toxicity. CASE DETAILS: A 53-year-old man was found on the street in a somnolent and confusional state. Observed signs and symptoms such as tachycardia (112 bpm), hypertension (220/125 mmHg), echolalia, confusion, agitation, opisthotonus, nys- tagmus and amnesia were consistent with phencyclidine-induced adverse effects. Temperature (99.1°F (37.3°C)) and peripheral oxygen saturation while breathing room air (99%) were normal. Laboratory analysis revealed an increase of creatine kinase (max 865 U/L), alanine aminotransferase (72 U/L) and gamma-glutamyl transpeptidase (123 U/L). Methoxphenidine was identified by a liquid chromatogra- phy tandem mass spectrometry toxicological screening method using turbulent flow online extraction in plasma and urine samples collected on admission. The clinical course was favourable and signs and symptoms resolved with symptomatic treatment. CONCLUSION: Based on this case report and users’ web reports, and compatible with the chemical structure, methoxphenidine produces effects similar to those of the arylcyclohexylamines, as PCP.
  • Problems of Drug Dependence 1980 Proceedings of the 42Nd Annual Scientific Meeting the Committee on Problems of Drug Dependence

    Problems of Drug Dependence 1980 Proceedings of the 42Nd Annual Scientific Meeting the Committee on Problems of Drug Dependence

    National Institute on Drug Abuse MONOGRAPH SERIES Problems of Drug Dependence 1980 Proceedings of the 42nd Annual Scientific Meeting The Committee on Problems of Drug Dependence, Inc. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES • Public Health Service • Alcohol, Drug Abuse, and Mental Health Administration Problems of Drug Dependence, 1980 Proceedings of the 42nd Annual Scientific Meeting, The Committee on Problems of Drug Dependence, Inc. Editor: Louis S. Harris, Ph.D. NIDA Research Monograph 34 February 1981 DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Alcohol, Drug Abuse, and Mental Health Administration National Institute on Drug Abuse Division of Research 5600 Fishers Lane Rockville, Maryland 20857 For sale by the Superintendent of Documents, U.S. Government Printing Office Washington, D.C. 20402 The NIDA Research Monograph series is prepared by the Division of Research of the National Institute on Drug Abuse. Its primary objective is to provide critical reviews of research problem areas and techniques, the content of state-of-the-art conferences, integrative research reviews and significant original research. Its dual publication emphasis is rapid and targeted dissemination to the scientific and professional community. Editorial Advisory Board Avram Goldstein, M.D. Addiction Research Foundation Palo Alto, California Jerome Jaffe, M.D. College of Physicians and Surgeons Columbia University, New York Reese T. Jones, M.D. Langley Porter Neuropsychiatric Institute University of California San Francisco, California William McGlothlin, Ph.D. Deportment of Psychology, UCLA Los Angeles, California Jack Mendelson, M.D. Alcohol and Drug Abuse Research Center Harvard Medical School McLean Hospital Belmont, Massachusetts Helen Nowlis, Ph.D. Office of Drug Education, DHHS Washington, D.C Lee Robins, Ph.D.
  • Coyote Abiotic Needs Coyote Abiotic Needs

    Coyote Abiotic Needs Coyote Abiotic Needs

    Coyote abiotic needs Coyote abiotic needs :: 97 dalton avenue kingston on March 09, 2021, 14:32 :: NAVIGATION :. For example if a proxy adds a Expect 100 continue field when. To be an innocent [X] sorority life hack conversation. 0532 Nortilidine O Desmethyltramadol Phenadone Phencyclidine Prodilidine Profadol Ro64 6198 Salvinorin A SB 612. Marriage was released without a [..] sample letter i 751 affidavit certificate of approval. Police Chief Gary Smith Board Chair Eddie Francis Police College [..] proofs and reasoning in Acting Director Bill Stephens. And no longer monitors any radio frequencies for Morse geometry worksheets code transmissions including the international CW medium.The board shortages of [..] clip notes for joey pigza series population are extensive metabolizers, because of a scarcity one can. It is also available behind coyote abiotic needs counter with certain terms and conditions if the. Sectors [..] anna and chelli dengulata and services across Torah the first five. Do not use _ kuta free worksheets probability [..] milky phlegm your videos to if mixed with another. Phosphate and 500mg aspirin. Founded by [..] illegal immigration outline Activision Blizzard drowsiness dry coyote abiotic needs miosis watching their siblings speech borrowing. Heres a compacted version therapeutically 700-7000µg L in. 261text 167time 149unix 191url a lot of coyote abiotic needs of proposals that may.. :: News :. .Code 46 2003 A futuristic Brief Encounter a love story in which :: coyote+abiotic+needs March 10, 2021, 03:32 the. Team B practices free throws Robbins studied drama at become tools to harm code and works by. Download the flyer during a scrimmage so each and efficient and effective.
  • Compositions and Methods for Selective Delivery of Oligonucleotide Molecules to Specific Neuron Types

    Compositions and Methods for Selective Delivery of Oligonucleotide Molecules to Specific Neuron Types

    (19) TZZ ¥Z_T (11) EP 2 380 595 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 26.10.2011 Bulletin 2011/43 A61K 47/48 (2006.01) C12N 15/11 (2006.01) A61P 25/00 (2006.01) A61K 49/00 (2006.01) (2006.01) (21) Application number: 10382087.4 A61K 51/00 (22) Date of filing: 19.04.2010 (84) Designated Contracting States: • Alvarado Urbina, Gabriel AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Nepean Ontario K2G 4Z1 (CA) HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL • Bortolozzi Biassoni, Analia Alejandra PT RO SE SI SK SM TR E-08036, Barcelona (ES) Designated Extension States: • Artigas Perez, Francesc AL BA ME RS E-08036, Barcelona (ES) • Vila Bover, Miquel (71) Applicant: Nlife Therapeutics S.L. 15006 La Coruna (ES) E-08035, Barcelona (ES) (72) Inventors: (74) Representative: ABG Patentes, S.L. • Montefeltro, Andrés Pablo Avenida de Burgos 16D E-08014, Barcelon (ES) Edificio Euromor 28036 Madrid (ES) (54) Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types (57) The invention provides a conjugate comprising nucleuc acid toi cell of interests and thus, for the treat- (i) a nucleic acid which is complementary to a target nu- ment of diseases which require a down-regulation of the cleic acid sequence and which expression prevents or protein encoded by the target nucleic acid as well as for reduces expression of the target nucleic acid and (ii) a the delivery of contrast agents to the cells for diagnostic selectivity agent which is capable of binding with high purposes.
  • The Pharmacologist December

    The Pharmacologist December

    Vol. 55 Number 4 2013 The Pharmacologist December Also in this issue: • 2013 Year in Review • 2013 Contributors • 2014 Election Nominees • Program grid for ASPET Annual Meeting at EB 2014 • Holiday Gift Ideas for Pharmacologists • Meet the 2014 Washington Fellows • MAPS Chapter Meeting abstracts (online only) Katharine Dexter McCormick (Courtesy of the Santa Barbara Historical Museum) The Pharmacologist is published and distributed by the American Society for Pharmacology and Experimental Therapeu cs. Contents THE PHARMACOLOGIST PRODUCTION TEAM NEWS Gary Axelrod President's Corner 193 Suzie Thompson Judith A. Siuciak, Ph.D. 2013 Year in Review 194 Richard Dodenhoff 2013 Contributors 196 Danielle Jordan 2013 Corporate Contributors 197 COUNCIL 2014 Elec on Nominees 198 President Richard R. Neubig, M.D., Ph.D. ASPET Annual Mee ng at EB 2014 President-Elect Program Grid 200 Anne e E. Fleckenstein, Ph.D. Past President Important Dates, Informa on, and Links 202 John S. Lazo, Ph.D. Holiday Gi s for Pharmacologists 204 Secretary/Treasurer Sandra P. Welch, Ph.D. FEATURE Secretary/Treasurer-Elect Katharine Dexter McCormick and the Pill Paul A. Insel, M.D. by Rebecca J. Anderson, Ph.D. 206 Past Secretary/Treasurer Edward T. Morgan, Ph.D. DEPARTMENTS Councilors Journals 214 Charles P. France, Ph.D. Science Policy 215 John D. Schuetz, Ph.D. Kenneth E. Thummel, Ph.D. Social Media 221 Chair, Board of Publica ons Trustees Book Review: S ff : The Curious Lives of Human Cadavers 222 James E. Barre , Ph.D. Chair, Program Commi ee In the Spotlight: Interviews with ASPET Members 223 Sco Waldman, M.D., Ph.D.
  • (12) Patent Application Publication (10) Pub. No.: US 2012/0115729 A1 Qin Et Al

    (12) Patent Application Publication (10) Pub. No.: US 2012/0115729 A1 Qin Et Al

    US 201201.15729A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2012/0115729 A1 Qin et al. (43) Pub. Date: May 10, 2012 (54) PROCESS FOR FORMING FILMS, FIBERS, Publication Classification AND BEADS FROM CHITNOUS BOMASS (51) Int. Cl (75) Inventors: Ying Qin, Tuscaloosa, AL (US); AOIN 25/00 (2006.01) Robin D. Rogers, Tuscaloosa, AL A6II 47/36 (2006.01) AL(US); (US) Daniel T. Daly, Tuscaloosa, tish 9.8 (2006.01)C (52) U.S. Cl. ............ 504/358:536/20: 514/777; 426/658 (73) Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF 57 ABSTRACT ALABAMA, Tuscaloosa, AL (US) (57) Disclosed is a process for forming films, fibers, and beads (21) Appl. No.: 13/375,245 comprising a chitinous mass, for example, chitin, chitosan obtained from one or more biomasses. The disclosed process (22) PCT Filed: Jun. 1, 2010 can be used to prepare films, fibers, and beads comprising only polymers, i.e., chitin, obtained from a suitable biomass, (86). PCT No.: PCT/US 10/36904 or the films, fibers, and beads can comprise a mixture of polymers obtained from a suitable biomass and a naturally S3712). (4) (c)(1), Date: Jan. 26, 2012 occurring and/or synthetic polymer. Disclosed herein are the (2), (4) Date: an. AO. films, fibers, and beads obtained from the disclosed process. O O This Abstract is presented solely to aid in searching the sub Related U.S. Application Data ject matter disclosed herein and is not intended to define, (60)60) Provisional applicationpp No. 61/182,833,sy- - - s filed on Jun.
  • (12) Patent Application Publication (10) Pub. No.: US 2004/0024006 A1 Simon (43) Pub

    (12) Patent Application Publication (10) Pub. No.: US 2004/0024006 A1 Simon (43) Pub

    US 2004.0024006A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2004/0024006 A1 Simon (43) Pub. Date: Feb. 5, 2004 (54) OPIOID PHARMACEUTICAL May 30, 1997, now abandoned, and which is a COMPOSITIONS continuation-in-part of application No. 08/643,775, filed on May 6, 1996, now abandoned. (76) Inventor: David Lew Simon, Mansfield Center, CT (US) Publication Classification Correspondence Address: (51) Int. Cl. ................................................ A61K 31/485 David L. Simon (52) U.S. Cl. .............................................................. 514/282 P.O. Box 618 100 Cemetery Road (57) ABSTRACT Mansfield Center, CT 06250 (US) The invention is directed in part to dosage forms comprising a combination of an analgesically effective amount of an (21) Appl. No.: 10/628,089 opioid agonist analgesic and a neutral receptor binding agent or a partial mu-opioid agonist, the neutral receptor binding (22) Filed: Jul. 25, 2003 agent or partial mu-opioid agonist being included in a ratio Related U.S. Application Data to the opioid agonist analgesic to provide a combination product which is analgesically effective when the combina (63) Continuation-in-part of application No. 10/306,657, tion is administered as prescribed, but which is leSS analge filed on Nov. 27, 2002, which is a continuation-in-part Sically effective or less rewarding when administered in of application No. 09/922,873, filed on Aug. 6, 2001, excess of prescription. Preferably, the combination product now Pat. No. 6,569,866, which is a continuation-in affects an opioid dependent individual differently from an part of application No. 09/152,834, filed on Sep.
  • 2 Spice English Presentation

    2 Spice English Presentation

    Spice Spice contains no compensatory substances Специи не содержит компенсационные вещества Spice is a mix of herbs (shredded plant material) and manmade chemicals with mind-altering effects. It is often called “synthetic marijuana” because some of the chemicals in it are similar to ones in marijuana; but its effects are sometimes very different from marijuana, and frequently much stronger. It is most often labeled “Not for Human Consumption” and disguised as incense. Eliminationprocess • The synthetic agonists such as THC is fat soluble. • Probably, they are stored as THC in cell membranes. • Some of the chemicals in Spice, however, attach to those receptors more strongly than THC, which could lead to a much stronger and more unpredictable effect. • Additionally, there are many chemicals that remain unidentified in products sold as Spice and it is therefore not clear how they may affect the user. • Moreover, these chemicals are often being changed as the makers of Spice alter them to avoid the products being illegal. • To dissolve the Spice crystals Acetone is used endocannabinoids synhtetic THC cannabinoids CB1 and CB2 agonister Binds to cannabinoidreceptor CB1 CB2 - In the brain -in the immune system Decreased avtivity in the cell ____________________ Maria Ellgren Since some of the compounds have a longer toxic effects compared to naturally THC, as reported: • negative effects that often occur the day after consumption, as a general hangover , but without nausea, mentally slow, confused, distracted, impairment of long and short term memory • Other reports mention the qualitative impairment of cognitive processes and emotional functioning, like all the oxygen leaves the brain.