Allergy to Quinolones: Low Cross-Reactivity to Levofloxacin
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
1057-1064, 1984 the Effect of Pipemidic Acid on The
Microbiol. Immunol. Vol. 28 (9), 1057-1064, 1984 The Effect of Pipemidic Acid on the Growth of a Stable L-Form of •ôNH•ôStaphylococcus aureus•ôNS•ô Kunihiko YABU,*,1 Hiromi ToMizu,1 and Yayoi KANDA2 1 Department of Biology, Hokuriku University School of Pharmacy, Kanazawa-machi, Kanazawa, Ishikawa ,920-11, and 2Department of Microbiology, Teikyo University School of Medicine, Kaga 2-chome, Ilabashi-ku, Tokyo 173 (Accepted for publication, June 12, 1984) Bacterial L-forms usually display spherical forms in an osmotically protective medium and seem to lack the typical binary fission process of cellular division ob servedin most bacteria (7). Although various modes of replication, such as budding binary fission, and release of elementary bodies from large bodies have been observed by light and electron microscopy (2, 5, 16), little is known about the processes involved in replication of L-forms. In the course of an experiment designed to test the effect of DNA synthesis inhibitors on the growth of a stable L-form of •ôNH•ôStaphylococcus•ôNS•ôaureus which grows in liquid medium, it was found that pipemidic acid, a synthetic antibacterial agent structurally related to nalidixic acid (13), induced a marked morphological altera tionat growth inhibitory concentrations. This study was initiated in an attempt to clarify the mechanism of replication of stable L-forms by analyzing the mor phologicalalteration caused by pipemidic acid. The stable L-form used was isolated as follows. S. •ôNH•ôaureus•ôNS•ôFDA 209P was grown in 10ml of Brain Heart Infusion broth (Difco) at 37C. The culture grown at 5•~105 colony-forming units (CFU) per ml was washed with saline by filtration and suspended in saline containing 100ƒÊg of N-methyl-N'-nitro-N-nitrosoguanidine per nil. -
Clinically Isolated Chlamydia Trachomatis Strains
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, JUIY 1988, p. 1080-1081 Vol. 32, No. 7 0066-4804/88/071080-02$02.00/0 Copyright © 1988, American Society for Microbiology In Vitro Activities of T-3262, NY-198, Fleroxacin (AM-833; RO 23-6240), and Other New Quinolone Agents against Clinically Isolated Chlamydia trachomatis Strains HIROSHI MAEDA,* AKIRA FUJII, KATSUHISA NAKATA, SOICHI ARAKAWA, AND SADAO KAMIDONO Department of Urology, School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe-city, Japan Received 9 December 1987/Accepted 29 March 1988 The in vitro activities of three newly developed quinolone drugs (T-3262, NY-198, and fleroxacin [AM-833; RO 23-6240]) against 10 strains of clinically isolated Chiamydia trachomatis were assessed and compared with those of other quinolones and minocycline. T-3262 (MIC for 90% of isolates tested, 0.1 ,ug/ml) was the most active of the quinolones. The NY-198 and fleroxacin MICs for 90% of isolates were 3.13 and 62.5 ,ug/ml, respectively. Recently, it has become well known that Chlamydia 1-ml sample of suspension was seeded into flat-bottomed trachomatis is an important human pathogen. It is respon- tubes with glass cover slips and incubated at 37°C in 5% CO2 sible not only for trachoma but also for sexually transmitted for 24 h. The monolayer was inoculated with 103 inclusion- infections, including lymphogranuloma venereum. In forming units of C. trachomatis. The tubes were centrifuged women, it causes cervicitis, endometritis, and salpingitis at 2,000 x g at 25°C for 45 min and left undisturbed at room asymptomatically (19), while in men it causes nongono- temperature for 2 h. -
A TWO-YEAR RETROSPECTIVE ANALYSIS of ADVERSE DRUG REACTIONS with 5PSQ-031 FLUOROQUINOLONE and QUINOLONE ANTIBIOTICS 24Th Congress Of
A TWO-YEAR RETROSPECTIVE ANALYSIS OF ADVERSE DRUG REACTIONS WITH 5PSQ-031 FLUOROQUINOLONE AND QUINOLONE ANTIBIOTICS 24th Congress of V. Borsi1, M. Del Lungo2, L. Giovannetti1, M.G. Lai1, M. Parrilli1 1 Azienda USL Toscana Centro, Pharmacovigilance Centre, Florence, Italy 2 Dept. of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), 27-29 March 2019 Section of Pharmacology and Toxicology , University of Florence, Italy BACKGROUND PURPOSE On 9 February 2017, the Pharmacovigilance Risk Assessment Committee (PRAC) initiated a review1 of disabling To review the adverse drugs and potentially long-lasting side effects reported with systemic and inhaled quinolone and fluoroquinolone reactions (ADRs) of antibiotics at the request of the German medicines authority (BfArM) following reports of long-lasting side effects systemic and inhaled in the national safety database and the published literature. fluoroquinolone and quinolone antibiotics that MATERIAL AND METHODS involved peripheral and central nervous system, Retrospective analysis of ADRs reported in our APVD involving ciprofloxacin, flumequine, levofloxacin, tendons, muscles and joints lomefloxacin, moxifloxacin, norfloxacin, ofloxacin, pefloxacin, prulifloxacin, rufloxacin, cinoxacin, nalidixic acid, reported from our pipemidic given systemically (by mouth or injection). The period considered is September 2016 to September Pharmacovigilance 2018. Department (PVD). RESULTS 22 ADRs were reported in our PVD involving fluoroquinolone and quinolone antibiotics in the period considered and that affected peripheral or central nervous system, tendons, muscles and joints. The mean patient age was 67,3 years (range: 17-92 years). 63,7% of the ADRs reported were serious, of which 22,7% caused hospitalization and 4,5% caused persistent/severe disability. 81,8% of the ADRs were reported by a healthcare professional (physician, pharmacist or other) and 18,2% by patient or a non-healthcare professional. -
Antibiotic Resistance in the European Union Associated with Therapeutic Use of Veterinary Medicines
The European Agency for the Evaluation of Medicinal Products Veterinary Medicines Evaluation Unit EMEA/CVMP/342/99-Final Antibiotic Resistance in the European Union Associated with Therapeutic use of Veterinary Medicines Report and Qualitative Risk Assessment by the Committee for Veterinary Medicinal Products 14 July 1999 Public 7 Westferry Circus, Canary Wharf, London, E14 4HB, UK Switchboard: (+44-171) 418 8400 Fax: (+44-171) 418 8447 E_Mail: [email protected] http://www.eudra.org/emea.html ãEMEA 1999 Reproduction and/or distribution of this document is authorised for non commercial purposes only provided the EMEA is acknowledged TABLE OF CONTENTS Page 1. INTRODUCTION 1 1.1 DEFINITION OF ANTIBIOTICS 1 1.1.1 Natural antibiotics 1 1.1.2 Semi-synthetic antibiotics 1 1.1.3 Synthetic antibiotics 1 1.1.4 Mechanisms of Action 1 1.2 BACKGROUND AND HISTORY 3 1.2.1 Recent developments 3 1.2.2 Authorisation of Antibiotics in the EU 4 1.3 ANTIBIOTIC RESISTANCE 6 1.3.1 Microbiological resistance 6 1.3.2 Clinical resistance 6 1.3.3 Resistance distribution in bacterial populations 6 1.4 GENETICS OF RESISTANCE 7 1.4.1 Chromosomal resistance 8 1.4.2 Transferable resistance 8 1.4.2.1 Plasmids 8 1.4.2.2 Transposons 9 1.4.2.3 Integrons and gene cassettes 9 1.4.3 Mechanisms for inter-bacterial transfer of resistance 10 1.5 METHODS OF DETERMINATION OF RESISTANCE 11 1.5.1 Agar/Broth Dilution Methods 11 1.5.2 Interpretative criteria (breakpoints) 11 1.5.3 Agar Diffusion Method 11 1.5.4 Other Tests 12 1.5.5 Molecular techniques 12 1.6 MULTIPLE-DRUG RESISTANCE -
Photodegradation Assessment of Ciprofloxacin, Moxifloxacin
Hubicka et al. Chemistry Central Journal 2013, 7:133 http://journal.chemistrycentral.com/content/7/1/133 RESEARCH ARTICLE Open Access Photodegradation assessment of ciprofloxacin, moxifloxacin, norfloxacin and ofloxacin in the presence of excipients from tablets by UPLC-MS/MS and DSC Urszula Hubicka1*, PawełŻmudzki2, Przemysław Talik1, Barbara Żuromska-Witek1 and Jan Krzek1 Abstract Background: Ciprofloxacin (CIP), moxifloxacin (MOX), norfloxacin (NOR) and ofloxacin (OFL), are the antibacterial synthetic drugs, belonging to the fluoroquinolones group. Fluoroquinolones are compounds susceptible to photodegradation process, which may lead to reduction of their antibacterial activity and to induce phototoxicity as a side effect. This paper describes a simple, sensitive UPLC-MS/MS method for the determination of CIP, MOX, NOR and OFL in the presence of photodegradation products. Results: Chromatographic separations were carried out using the Acquity UPLC BEH C18 column; (2.1 × 100 mm, 1.7 μm particle size). The column was maintained at 40°C, and the following gradient was used: 0 min, 95% of eluent A and 5% of eluent B; 10 min, 0% of eluent A and 100% of eluent B, at a flow rate of 0.3 mL min-1. Eluent A: 0.1% (v/v) formic acid in water; eluent B: 0.1% (v/v) formic acid in acetonitrile. The method was validated and all the validation parameters were in the ranges acceptable by the guidelines for analytical method validation. The photodegradation of examined fluoroquinolones in solid phase in the presence of excipients followed kinetic of the first order reaction and depended upon the type of analyzed drugs and coexisting substances. -
Fluoroquinolone Antibiotics: Ciprofloxacin, Levofloxacin, Moxifloxacin, Ofloxacin
21 March 2019 DDL_fluoroquinolones_March-2019 Fluoroquinolone antibiotics: ciprofloxacin, levofloxacin, moxifloxacin, ofloxacin New restrictions and precautions due to very rare reports of disabling and potentially long-lasting or irreversible side effects • Disabling, long-lasting or potentially irreversible adverse reactions affecting musculoskeletal (including tendonitis and tendon rupture) and nervous systems have been reported with fluoroquinolone antibiotics – see Drug Safety Update for more information • Prescribers and dispensers of fluoroquinolones should advise patients to stop treatment at the first signs of a serious adverse reaction, such as tendinitis or tendon rupture, muscle pain, muscle weakness, joint pain, joint swelling, peripheral neuropathy, and central nervous system effects, and to contact their doctor immediately for further advice – see MHRA sheet to discuss measures with patients • Fluoroquinolone treatment should be discontinued at the first sign of tendon pain or inflammation in patients and the affected limb or limbs appropriately treated (for example with immobilisation) Fluoroquinolones should not be prescribed for: • non-severe or self-limiting infections, or non-bacterial conditions • mild to moderate infections (such as in acute exacerbation of chronic bronchitis and chronic obstructive pulmonary disease) unless other antibiotics that are commonly recommended for these infections are considered inappropriate* • uncomplicated cystitis (for which ciprofloxacin or levofloxacin were previously authorised) -
(-Oxacins): What You Need to Know About Side Effects of Tendons, Muscles, Joints, and Nerves March 2019
Fluoroquinolone antibiotics (-oxacins): what you need to know about side effects of tendons, muscles, joints, and nerves March 2019 • Fluoroquinolone medicines (ciprofloxacin, levofloxacin, moxifloxacin, and ofloxacin) are effective antibiotics that treat serious and life-threatening infections in the body • Always take your doctor’s advice on when and how to take antibiotics • Fluoroquinolones have been reported to cause serious side effects involving tendons, muscles, joints, and the nerves – in a small proportion of patients, these side effects caused long-lasting or permanent disability Stop taking your fluoroquinolone antibiotic and contact your doctor immediately if you have the following signs of a side effect: o Tendon pain or swelling, often beginning in the ankle or calf - if this happens, rest the painful area until you can see your doctor o Pain in your joints or swelling in your shoulder, arms, or legs o Abnormal pain or sensations (such as persistent pins and needles, tingling, tickling, numbness, or burning), weakness in your body, especially in the legs or arms, or difficulty walking o Severe tiredness, depressed mood, anxiety, or problems with your memory or severe problems sleeping o Changes in your vision, taste, smell, or hearing • Tell your doctor if you have had one of the above effects during or shortly after taking a fluoroquinolone – this means you should avoid them in the future • Doctors will take special care with these medicines if you are older than 60 years of age, if your kidneys do not work well, or if -
Evaluation of Antibiotic Consumption at Rakovica Community Health Center
ORIGINAL SCIENTIFIC PAPER ORIGINALNI NAUČNI RAD ORIGINAL SCIENTIFIC PAPER EVALUATION OF ANTIBIOTIC CONSUMPTION AT RAKOVICA COMMUNITY HEALTH CENTER FROM 2011 TO 2015 Marijana Tomic Smiljanic1, Vesela Radonjic2, Dusan Djuric3 1 Community Health Center in Rakovica, Belgrade, Serbia 2 Medicines and Medical Devices Agency of Serbia, Belgrade; University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Pharmacy 3 University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Pharmacy EVALUACIJA POTROŠNJE ANTIBIOTIKA U DOMU ZDRAVLJA RAKOVICA U PERIODU 2011_2015. GODINA Marijana Tomić Smiljanić1, Vesela Radonjić2, Dušan Đurić3 1 Dom zrdavlja Rakovica, Beograd, Srbija 2 Agencija za lekove i medicinska sredstva Srbije, Beograd, Univerzitet u Kragujevcu, Srbija, Fakultet medicinskih nauka, Odsek za farmaciju 3 Univerzitet u Kragujevcu, Srbija, Fakultet medicinskih nauka, Odsek za farmaciju Received / Primljen: 08.06.2016. Accepted / Prihvaćen: 12.07.2016. ABSTRACT SAŽETAK Antibacterial drugs are among the major discoveries of the Antibakterijski lekovi su među najvećim otkrićima 20. 20th century because they signifi cantly reduced the rate of mor- veka, jer su znatno smanjili stopu obolevanja i smrtnosti bidity and mortality as well as the risk of infections related to od infektivnih bolesti i rizik od infekcije kod invazivnih invasive medical procedures. Indiscriminate and wrongful use medicinskih procedura. Neodgovorna i pogrešna upotre- of these powerful life-saving drugs has led to the development ba ovih moćnih lekova koji spasavaju život dovela je do of resistance of numerous microorganisms, resulting in an in- razvoja rezistencije mnogih mikroorganizama na njih, a crease in the number of hospital-acquired infections with a fatal rezultat toga je i porast bolničkih infekcija sa smrtnim outcome. -
Daily Moxifloxacin, Clarithromycin, Minocycline, and Clofazimine In
ISSN: 2643-461X Neto et al. Int J Trop Dis 2020, 3:035 DOI: 10.23937/2643-461X/1710035 Volume 3 | Issue 2 International Journal of Open Access Tropical Diseases CASE SERIES Daily Moxifloxacin, Clarithromycin, Minocycline, and Clofazimine in Nonresponsiveness Leprosy Cases to Recommended Treatment Regimen Francisco Bezerra de Almeida Neto, MD1,2,3*, Rebeca Daniele Buarque Feitosa, OT3 and Marqueline Soares da Silva, RN3 1Department of Dermatology, Mauricio de Nassau Recife University Center, Brazil Check for 2Department of Tropical Medicine, Federal University of Pernambuco (UFPE), Brazil updates 3Cabo de Santo Agostinho Health Care Hansen's Disease Specialized Center, Cabo de Santo Agostinho, Brazil *Corresponding author: Francisco Bezerra de Almeida Neto, MD, Department of Dermatology, Mauricio de Nassau Recife University Center; Department of Tropical Medicine, Federal University of Pernambuco (UFPE); Cabo de Santo Agostinho Health Care Hansen's Disease Specialized Center, Cabo de Santo Agostinho, R Jonathas de Vasconcelos, 316, Boa Viagem, Recife, PE, CEP 51021140, Brazil, Tel: +5581988484442 Abstract Introduction Background: In hyperendemic countries for leprosy, there Although leprosy is the first infectious disease at- has been a growing increase in clinical multibacillary “non- tributed to a pathogen by Gerard Amauer Hansen, it responsiveness” leprosy cases to the fixed-duration treat- remains a relevant public health problem in countries ment recommended by World Health Organization (MDT- MB). There are no defined protocols to treat these patients. considered hyper-endemic for the disease [1]. Methods: A retrospective, observational case series study The main etiologic agents areMycobacterium leprae was conducted of 4 patients with multibacillary leprosy who and Mycobacterium lepromatosis. The clinical mani- presented to a specialized Leprosy health care. -
Paper I and II)
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1335 Constraints on up-regulation of drug efflux in the evolution of ciprofloxacin resistance LISA PRASKI ALZRIGAT ACTA UNIVERSITATIS UPSALIENSIS ISSN 1651-6206 ISBN 978-91-554-9923-5 UPPSALA urn:nbn:se:uu:diva-320580 2017 Dissertation presented at Uppsala University to be publicly examined in B22, BMC, Husargatan 3, Uppsala, Friday, 9 June 2017 at 09:00 for the degree of Doctor of Philosophy (Faculty of Medicine). The examination will be conducted in English. Faculty examiner: Professor Fernando Baquero (Departamento de Microbiología, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain). Abstract Praski Alzrigat, L. 2017. Constraints on up-regulation of drug efflux in the evolution of ciprofloxacin resistance. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1335. 48 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9923-5. The crucial role of antibiotics in modern medicine, in curing infections and enabling advanced medical procedures, is being threatened by the increasing frequency of resistant bacteria. Better understanding of the forces selecting resistance mutations could help develop strategies to optimize the use of antibiotics and slow the spread of resistance. Resistance to ciprofloxacin, a clinically important antibiotic, almost always involves target mutations in DNA gyrase and Topoisomerase IV. Because ciprofloxacin is a substrate of the AcrAB-TolC efflux pump, mutations causing pump up-regulation are also common. Studying the role of efflux pump-regulatory mutations in the development of ciprofloxacin resistance, we found a strong bias against gene-inactivating mutations in marR and acrR in clinical isolates. -
Reduced Moxifloxacin Exposure in Patients with Tuberculosis and Diabetes
AGORA | RESEARCH LETTER Reduced moxifloxacin exposure in patients with tuberculosis and diabetes To the Editor: Prevalence of diabetes mellitus (DM) in patients with tuberculosis (TB) is increasing and may negatively impact TB outcomes in patients with active disease [1]. Gastrointestinal problems, including gastroparesis, may result in delayed drug absorption or malabsorption in patients with DM, which may cause suboptimal drug exposure and poor outcome [2]. Studies on the pharmacokinetics of the first-line anti-TB drugs in patients with DM yielded conflicting results on low drug exposure [3–7]. Moxifloxacin is a potent bactericidal drug against Mycobacterium tuberculosis and is key for the treatment of multidrug-resistant tuberculosis (MDR)-TB [8]. Moreover, moxifloxacin can be recommended for TB treatment in patients with monoresistance or intolerance to first-line drugs [9]. Recently, we reported on a patient with TB and DM in whom moxifloxacin exposure was reduced [10]. In this study, we aimed to evaluate moxifloxacin drug exposure in patients with TB and DM. We retrospectively identified all patients aged ⩾16 years who underwent routine therapeutic drug monitoring (TDM) using at least three time-points for moxifloxacin as part of their TB treatment at our centre in the period 2006–2018. For this study, the Medical Ethical Committee of the University Medical Center Groningen (Groningen, the Netherlands) waived the need for written informed consent due to the retrospective nature of the study (reference 2013/492). Patient data were processed according to the Declaration of Helsinki. Controls were TB patients without DM matched for age, sex and rifampicin use (cases/controls 1/1). -
Metal Complexes of Quinolone Antibiotics and Their Applications: an Update
Molecules 2013, 18, 11153-11197; doi:10.3390/molecules180911153 OPEN ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Review Metal Complexes of Quinolone Antibiotics and Their Applications: An Update Valentina Uivarosi Department of General and Inorganic Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia St, Bucharest 020956, Romania; E-Mail: [email protected]; Tel.: +4-021-318-0742; Fax: +4-021-318-0750 Received: 8 August 2013; in revised form: 2 September 2013 / Accepted: 2 September 2013 / Published: 11 September 2013 Abstract: Quinolones are synthetic broad-spectrum antibiotics with good oral absorption and excellent bioavailability. Due to the chemical functions found on their nucleus (a carboxylic acid function at the 3-position, and in most cases a basic piperazinyl ring (or another N-heterocycle) at the 7-position, and a carbonyl oxygen atom at the 4-position) quinolones bind metal ions forming complexes in which they can act as bidentate, as unidentate and as bridging ligand, respectively. In the polymeric complexes in solid state, multiple modes of coordination are simultaneously possible. In strongly acidic conditions, quinolone molecules possessing a basic side nucleus are protonated and appear as cations in the ionic complexes. Interaction with metal ions has some important consequences for the solubility, pharmacokinetics and bioavailability of quinolones, and is also involved in the mechanism of action of these bactericidal agents. Many metal complexes with equal or enhanced antimicrobial activity compared to the parent quinolones were obtained. New strategies in the design of metal complexes of quinolones have led to compounds with anticancer activity.