DOCSLIB.ORG

Botulinum Toxin in the Treatment of Sweatworsened Foot Problems In

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Botulinum Toxin in the Treatment of Sweatworsened Foot Problems In 15 March 2005 Use of Articles in the Pachyonychia Congenita Bibliography The articles in the PC Bibliography may be restricted by copyright laws. These have been made available to you by PC Project for the exclusive use in teaching, scholar- ship or research regarding Pachyonychia Congenita. To the best of our understanding, in supplying this material to you we have followed the guidelines of Sec 107 regarding fair use of copyright materials. That section reads as follows: Sec. 107. - Limitations on exclusive rights: Fair use Notwithstanding the provisions of sections 106 and 106A, the fair use of a copyrighted work, including such use by reproduction in copies or phonorecords or by any other means specified by that section, for purposes such as criticism, comment, news reporting, teaching (including multiple copies for classroom use), scholarship, or research, is not an infringement of copyright. In determining whether the use made of a work in any particular case is a fair use the factors to be considered shall include - (1) the purpose and character of the use, including whether such use is of a commercial nature or is for nonprofit educational purposes; (2) the nature of the copyrighted work; (3) the amount and substantiality of the portion used in relation to the copyrighted work as a whole; and (4) the effect of the use upon the potential market for or value of the copyrighted work. The fact that a work is unpublished shall not itself bar a finding of fair use if such finding is made upon consideration of all the above factors. We hope that making available the relevant information on Pachyonychia Congenita will be a means of furthering research to find effective therapies and a cure for PC. 2386 East Heritage Way, Suite B, Salt Lake City, Utah 84109 USA Phone +1-877-628-7300 • Email—[email protected] www.pachyonychia.org BJD THERAPEUTICS British Journal of Dermatology Botulinum toxin in the treatment of sweat-worsened foot problems in patients with epidermolysis bullosa simplex and pachyonychia congenita C. Swartling,* M. Karlqvist,*à K. Hymnelius,* J. Weis§ and A. Vahlquist* Departments of *Dermatology and §Radiology, and àCentre for Research and Development, County Council of Ga¨vleborg, Uppsala University, University Hospital, SE-751 85 Uppsala, Sweden Sophiahemmet AB, Hidrosis Clinic, Box 5605, SE-114 86 Stockholm, Sweden Summary Correspondence Background Painful foot blistering is a common problem in patients with epider- Carl Swartling. molysis bullosa simplex (EBS) and pachyonychia congenita (PC). Hyperhidrosis, E-mail: [email protected] a condition which can be effectively blocked by plantar injections of botulinum toxin (Btx), often exacerbates the blistering. Accepted for publication 22 June 2010 Objectives A retrospective evaluation of the effects of Btx injections in 14 patients with EBS and PC with foot blisters and painful callosities. Key words Methods After informed consent, patients with EBS (n = 6) and PC (n = 8), aged blisters, botulinum toxin, callus, epidermolytic 7–66 years, who had received Btx therapy at our centre since 2003, were disorders, hyperhidrosis, keratin mutation included. The treatment consisted of multiple plantar injections of Btx A or Btx B Conflicts of interest after prior regional or general anaesthesia. Patients were interviewed about the None declared. treatment effect and were asked to score the improvement from 0 to 5, where 5 is ‘excellent’. One patient with PC with painful callosities was studied by DOI 10.1111/j.1365-2133.2010.09927.x magnetic resonance (MR) spectroscopic microimaging before and after Btx injec- tions to disclose any underlying blisters. Results In total, 76 treatments were evaluated (one to 19 sessions per patient). Thirteen patients (93%) reported reduced plantar blistering and pain; the improvement score was ‡ 4 in four of six patients with EBS and six of eight patients with PC. The mean effect duration was 3 months. No adverse events, apart from mild anticholinergic side-effects in two patients, were noted. MR spectroscopic microimaging showed disappearance of intraepidermal blistering after Btx therapy. Conclusions Plantar injection of Btx is an efficient, long-lasting and safe treatment of painful blistering and callosities in EBS and PC that can be given repeatedly without loss of efficacy. Epidermolysis bullosa simplex (EBS) and pachyonychia con- [Dowling–Meara (DM); 1 : 200 000] with blistering all over genita (PC) belong to a group of congenital keratinopathies the body.4 PC (OMIM 167200 ⁄167210) has a prevalence of characterized by stress-induced epidermolysis and hyperkerato- about 1 : 100 000. It starts with thickening of the nails and is sis due to cytoskeletal fragility and clumping of intermediate later followed by foot blisters and painful callosities. Two filaments (IFs). There is no curative treatment for keratino- forms of PC exist: type 1 with mucosal involvement, and type pathies, but siRNA therapy has shown promising results in 2 with steatocystoma multiplex.5 PC.1 In patients with both EBS and PC, foot blisters and callosi- EBS and PC are caused by dominant negative keratin muta- ties deteriorate in a hot and humid environment, especially tions affecting the heterodimerization of IFs expressed in the when plantar hyperhidrosis is prominent. Alas, topical anti- basal and spinous layers of epidermis and encoded by sweating agents, such as glutaric aldehyde and aluminium KRT5 ⁄KRT14 and KRT6 ⁄KRT16 ⁄17, respectively.2,3 EBS (OMIM chloride, are insufficient to reduce the foot problems.6 How- 131800 ⁄131760) exists in two forms: the localized subtype ever, intracutaneous injection of botulinum toxin (Btx) is a previously called Weber–Cockayne; prevalence 1:25 000) with more efficacious treatment of focal hyperhidrosis.7,8 Btx inhib- predominantly foot blisters, and the generalized subtype its eccrine sweat glands by blocking the acetylcholine Ó 2010 The Authors 1072 BJD Ó 2010 British Association of Dermatologists 2010 163, pp1072–1076 Botulinum toxin for EBS and PC, C. Swartling et al. 1073 pathway. The anaerobic bacterium Clostridium botulinum produces PC were included in a previous report of the short-term different types of Btx named A to G. Type A and type B are effects of Btx therapy.11 commercially available. Btx A and Btx B differ in pharmaco- dynamics, covering proteins and additives in the vials. Differ- Anaesthesia ent Btx A preparations are not exchangable regarding the potency of 1 U.9,10 Foot analgesia was accomplished either by bilateral intrave- Several years ago, we began treating a few patients with PC nous regional anaesthesia (IVRA)13 with a low tourniquet and ) by plantar injections of Btx and noticed a spectacular reduc- 25 mL prilocaine (5 mg mL 1) given intravenously to each tion in pain from walking.11 We also reported preliminary foot (n = 39 sessions), or by general anaesthesia (n =37 good results in two patients with EBS with pedal blisters,11 sessions). The selection of method was dependent on the which was recently confirmed by others.12 We have now trea- patient’s age and attitudes to anaesthesia (see Table 1). ted a total of 14 patients with EBS and PC, and wish to report in a retrospective study our experience with Btx therapy for Botulinum toxin injections this indication. After reducing the callosities by curettage, all patients received plantar injections with Btx A (DysportÒ; Ipsen, Patients and methods ) Slough, U.K.) 100 U mL 1. The individual doses are shown in Table 1. Due to treatment resistance, three patients were Patients later switched to Btx B (NeuroblocÒ; Eisai, Stockholm, Swe- ) Six patients with EBS of localized type or DM (age den) 250 U mL 1. Our initial strategy was to distribute Btx 7–46 years) and eight patients with PC of type 1 or 2 (age evenly on the sole, injecting it intradermally every 15 mm 26–66 years) were included in the study after informed in a checked pattern. This regimen was later modified so that consent (Table 1). The patients were referred from all parts only weight-bearing areas of the feet were treated, distri- of Sweden and were followed for a maximum of 6 years. A buting the same total dose especially below blisters and diagnosis of EBS or PC was established using clinical criteria, callosities. inheritance pattern, and ⁄or KRT mutation analysis (kindly Similar procedures have been repeatedly approved by the performed by Dr Paul Bowden, Cardiff, U.K., and Dr Marie local ethical committee in Uppsala for other studies of Btx Virtanen, in Uppsala). All patients had a history of sweat- therapy performed over the years.13 All treatments were worsened blisters or painful hyperkeratoses that negatively performed at the Department of Neurology, Uppsala Univer- affected their activities of daily life. Three of the patients with sity Hospital. Table 1 Patient characteristics, global outcome and details of the therapy with botulinum toxin (Btx) Global Preferred Age Clinical Affected No. of Dose (U) of Btx A improvement Effect duration type of Patient (years) ⁄sex subtype Inheritance gene treatments or Btx B (score)a (months) anaesthesia EBS 1b 7 ⁄F Loc. AD NA 3 A: 170–250 5 4 General EBS 2b 46 ⁄M Loc. AD NA 1 A: 300 (one foot) 4 3 IVRA EBS 3 24 ⁄F Loc. AD NA 4 A: 580–700 5 3Æ5 IVRA EBS 4 46 ⁄F DM AD K5 3 A: 576–600 5 3 IVRA EBS 5 30 ⁄M Loc. AD K5 1 A: 300 (one foot) 0 0 IVRA EBS 6 33 ⁄M DM AD K5 1 A: 315 (one foot) 3 3 IVRA PC 1 32 ⁄F PC-2 AD NA 2 A: 600 4 2 General PC 2b 36 ⁄F PC-2 AD NA 6 A: 600–700 4 3 IVRA PC 3b 66 ⁄M PC-2 AD NA 1 A: 600 3 3 IVRA PC 4c 26 ⁄M PC-1 Spor.
Load more

Recommended publications
  • White Lesions of the Oral Cavity and Derive a Differential Diagnosis Four for Various White Lesions
    2014 self-study course four course The Ohio State University College of Dentistry is a recognized provider for ADA, CERP, and AGD Fellowship, Mastership and Maintenance credit. ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry. Concerns or complaints about a CE provider may be directed to the provider or to ADA CERP at www.ada.org/goto/cerp. The Ohio State University College of Dentistry is approved by the Ohio State Dental Board as a permanent sponsor of continuing dental education ABOUT this FREQUENTLY asked COURSE… QUESTIONS… Q: Who can earn FREE CE credits? . READ the MATERIALS. Read and review the course materials. A: EVERYONE - All dental professionals in your office may earn free CE contact . COMPLETE the TEST. Answer the credits. Each person must read the eight question test. A total of 6/8 course materials and submit an questions must be answered correctly online answer form independently. for credit. us . SUBMIT the ANSWER FORM Q: What if I did not receive a ONLINE. You MUST submit your confirmation ID? answers ONLINE at: A: Once you have fully completed your p h o n e http://dent.osu.edu/sterilization/ce answer form and click “submit” you will be directed to a page with a . RECORD or PRINT THE 614-292-6737 unique confirmation ID. CONFIRMATION ID This unique ID is displayed upon successful submission Q: Where can I find my SMS number? of your answer form.
    [Show full text]
  • Foot Pain in Scleroderma
    Foot Pain in Scleroderma Dr Begonya Alcacer-Pitarch LMBRU Postdoctoral Research Fellow 20th Anniversary Scleroderma Family Day 16th May 2015 Leeds Institute of Rheumatic and Musculoskeletal Medicine Presentation Content n Introduction n Different types of foot pain n Factors contributing to foot pain n Impact of foot pain on Quality of Life (QoL) Leeds Institute of Rheumatic and Musculoskeletal Medicine Scleroderma n Clinical features of scleroderma – Microvascular (small vessel) and macrovascular (large vessel) damage – Fibrosis of the skin and internal organs – Dysfunction of the immune system n Unknown aetiology n Female to male ratio 4.6 : 1 n The prevalence of SSc in the UK is 8.21 per 100 000 Leeds Institute of Rheumatic and Musculoskeletal Medicine Foot Involvement in SSc n Clinically 90% of SSc patients have foot involvement n It typically has a later involvement than hands n Foot involvement is less frequent than hand involvement, but is potentially disabling Leeds Institute of Rheumatic and Musculoskeletal Medicine Different Types of Foot Pain Leeds Institute of Rheumatic and Musculoskeletal Medicine Ischaemic Pain (vascular) Microvascular disease (small vessel) n Intermittent pain – Raynaud’s (spasm) • Cold • Throb • Numb • Tingle • Pain n Constant pain – Vessel center narrows • Distal pain (toes) • Gradually increasing pain • Intolerable pain when necrosis is present Leeds Institute of Rheumatic and Musculoskeletal Medicine Ischaemic Pain (vascular) Macrovascular disease (large vessels) n Intermittent and constant pain – Peripheral Arterial Disease • Intermittent claudication – Muscle pain (ache, cramp) during walking • Aching or burning pain • Night and rest pain • Cramps Leeds Institute of Rheumatic and Musculoskeletal Medicine Ulcer Pain n Ulcer development – Constant pain n Infected ulcer – Unexpected/ excess pain or tenderness Leeds Institute of Rheumatic and Musculoskeletal Medicine Neuropathic Pain n Nerve damage is not always obvious.
    [Show full text]
  • Tocaloma Spa Services Menu
    Massage Tocaloma Signature 80 min. $210 Seaweed Body Wrap 50 min. $130 Restore Moisture Miracle Facial 50 min. $170 A decadent massage fully customizable to your specific Helps release stored toxins and relieve fluid retention, as When skin is stressed and compromised, it needs a needs. Includes a hydrating hand treatment and scalp well as hormonal and adrenal balancing. A body brush is restorative moisture miracle. This anti-aging facial will massage for the ultimate relaxation. used to exfoliate dead skin cells. Next, a warmed infuse deep hydration while boosting firmness leaving your application of seaweed envelopes the body while a skin feeling soft, nourished and renewed. Swedish 20 mins. $80 | 50 min. $120 | 80 min. $180 relaxing scalp massage soothes stress. After a eucalyptus Acne Clarifying Facial 50 min. $140 This treatment is ideal when arriving at Tapatio to welcome shower, moisture-rich body lotion is applied to leave skin you and ground your energy. Therapists focus on areas silky smooth. Improve skin clarity while combating acne and unbalanced prone to tension after traveling while utilizing long, relaxing skin. Improve skin smoothness, balance oil production, Sedona Purification Body Wrap 50 min. $130 strokes of light to medium pressure, providing instant relief unclog pores and speed up skin cell turnover while creating of pain and stiffness. Rich in minerals from the Arizona desert and derived from an overall glow and revealing healthy skin. the clays of the Southwest, this treatment will nourish, tone Therapeutic 20 mins. $100 | 50 min. $140 | 80 min. $200 Lighten & Brighten Facial 50 min. $160 and purify your skin.
    [Show full text]
  • “Relationship Between Smoking and Plantar Callus
    C HA PTER 3 8 RELATIONSHIP BETWEEN SMOKING AND PLANTAR CALLUS FORMATION OF THE FOOT Thomas J. Merrill, DPM Virginio Vena, DPM Luis A. Rodriguez, DPM Despite the decline in cigarette smoking in the last few smoke can remain in the body (6). The tobacco smoke years as reported by the Centers for Disease Control and components absorbed from the lungs reach the heart Prevention, and the well known health risks in cardiovascular immediately. Smoking increases the heart rate, arterial blood and pulmonary diseases, millions of Americans continue to pressure, and cardiac output. There is a 42% reduction in the smoke cigarettes. It has been proven by both experimental digital blood flow after a single cigarette (7, 8). Nicotine has and clinical observation that cigarettes impair bone and a direct cutaneous vasoconstrictive effect and is the principle wound healing. The purpose of this article is to review the vasoactive component in the gas phase of cigarette smoke. chemical components of cigarette smoke and its relationship It is an odorless, colorless, and poisonous alkaloid that when with plantar callus formation. inhaled or injected, can activate the adrenal catecholamines Increased plantar callus formation with patients who from the adrenergic nerve endings and from the adrenal smoke cigarettes seems to be a common problem. There are medulla, which cause vasoconstriction of vessels especially in approximately 46.6 million smokers in the US. There was a the extremities. Nicotine also induces the sympathetic decline during 1997-2003 in the youth population but nervous system, which results in the release of epinephrine during the last years the rates are stable (1).
    [Show full text]
  • For Peer Review Only
    Expert Opinion On Drug Metabolism & Toxicology For Peer Review Only Please download and read the Referee Guidelines Intravenous immunoglobulin: pharmacological properties and use in polyneuropathies Journal: Expert Opinion On Drug Metabolism and Toxicology Manuscript ID EOMT-2016-0106.R1 Manuscript Type: Review IVIg, CIDP, GBS, anti-idiotype antibodies, anti-ganglioside antibodies, Keywords: sialylation, IgG molecule., Fc receptors URL: http://mc.manuscriptcentral.com/eomt Email: [email protected] Page 1 of 60 Expert Opinion On Drug Metabolism & Toxicology 1 2 Abstract 3 4 Introduction: Intravenous immunoglobulin (IVIg) is increasingly used for the treatment of 5 6 autoimmune and systemic inflammatory diseases with both licensed and off-label indications. The 7 mechanism of action is complex and not fully understood, involving the neutralization of 8 9 pathological antibodies, Fc receptor blockade, complement inhibition, immunoregulation of 10 11 dendritic cells, B cells and T cells and the modulation of apoptosis. 12 13 14 Areas covered:For First, this Peerreview describes Review the pharmacological propertiesOnly of IVIg, including the 15 16 composition, mechanism of action, and adverse events. The second part gives an overview of some 17 of the immune-mediated polyneuropathies, with special focus on the pathomechanism and clinical 18 19 trials assessing the efficacy of IVIg. A literature search on PubMed was performed using the terms 20 21 IVIg, IVIg preparations, side effects, mechanism of action, clinical trials, GBS, CIDP. 22 23 24 Expert opinion: Challenges associated with IVIg therapy and the treatment possibilities for 25 26 immune-mediated polyneuropathies are discussed. The availability of IVIg is limited, the expenses 27 are high, and, in several diseases, a chronic therapy is necessary to maintain the immunomodulatory 28 29 effect.
    [Show full text]
  • Tumours of the Skin*
    TUMOURS OF THE SKIN* BY D. C. BODENHAM Skin tumours are so common that, directly or indirectly, they account for 48-5 per ent of all out operations in the Plastic Unit in Frenchay, and nearly half of those we With are malignant. So it seems appropriate that some of our experiences as a arn ?f surgeons and pathologists in this field should be the subject of a paper, * should to ask this in me some j. first like for your indulgence evening allowing Cence in the interpretation of the word "tumour". The classical description of most ^fliours can be found in any good reference work on the subject. There is no mystery. w^en a tumour which seems clearly to belong to one particular type proves to?KVeVer' then there is and interest Tumours seem to something different, mystery enough. delight in their fellows, and we must be prepared, for example, to find at mimicking what appears to be a typical squamous carcinoma is in fact a non-pigmented nant me^anoma- So too, an process may look and present lit ? exaggerated repair a malignant tumour. A. therefore chose to speak mainly about those presentations of ordinary tumour lch are not usually described, but which to me at least seem to be met with as requently as the text-book types. * he classification of my choice is not new, but has been chosen for its simplicity and rectness, because I can understand it, and I offer no apology for looking back 1,800 ars to Galen, who three broad of "tumour":? *? recognized types Those to nature 2* according (e.g.
    [Show full text]
  • 7343B63553fd73ca9deeb73956f
    QUIZ SECTION 475 Distinct Hyperkeratotic Lesions on Acral Skin and Lips: A Quiz 1# 1# 1,2 1 1,2 DV Youming MEI , Zhiming CHEN , Wei ZHANG , Jingshu XIONG and Hongsheng WANG 1Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, 210042, and 2Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China. E-mail: [email protected] cta #These authors contributed equally to this work. A A 50-year-old man presented with hyperkeratotic scales hyperkeratosis, acanthosis and hypergranulosis (Fig. 1F). on his lips, asymptomatic, round, discrete, hyperkeratotic, There was lymphocyte infiltration around the vessels and verrucous nodules on the dorsa of the interphalangeal and in the upper dermis, and mucin deposition in the superficial metacarpophalangeal joints, the left ear, right heel (Fig. and mid-dermis (Fig. 1G). Direct immunofluorescence of 1A–E), and poikiloderma over his fingers and left ear (Fig. IgG and complement 3 was negative. After treatment with 1B). The lesions had gradually increased over a period of methylprednisolone, 8 mg q.d., hydroxychloroquine 100 mg and viaminate 50 mg b.i.d., topical 0.05% halometasone 20 years. Laboratory examinations revealed reduced pla- cream b.i.d. for 1 month, the patient reported that most of telet number (92×109/l), positive antinuclear antibodies enereologica the lesions became flatter. (1:160, speckled pattern), anti-dsDNA and anti-SSA/Ro. V Histopatho logy of biopsied foot lesions revealed marked What is your diagnosis? See next page for answer. ermato- D cta A DV cta A Fig.
    [Show full text]
  • Intraoral 'Leukoplakia'
    Intraoral 'leukoplakia' SHATTUCK W. HARTWELL, JR., M.D. Department of Plastic Surgery LEUKOPLAKIA has become a convenient catchall term for many epithelial * abnormalities within the mouth. According to Sprague1 the term was first used by Schwimmer in 1887; it simply means "white patch." White patches are common in the mouth. Oral epithelium is constantly moist, and those abnormalities or portions of oral epithelium which are characterized by excess keratin will take on a white appearance because keratin character- istically turns white when it is thoroughly wet. As occurs with squamous epithelial surfaces elsewhere in the body, so too in healthy oral mucosa there is an orderly progression of epithelial cells toward the surface, and a continuing desquamation takes place without keratin accumulation. If a painless, unobtrusive, or even unnoticed, white patch in the mouth had no more significance than a callus on a laborer's hands, then there would be no problem to discuss. There is real danger, though, in intraoral leuko- plakia, since leukoplakia may be a premalignant condition or mask a lesion that is actually a carcinoma. WHAT IS INTRAORAL LEUKOPLAKIA? Leukoplakia is a term to be used strictly for a clinical diagnosis of a white mucosal patch. It has no precise histopathologic meaning; as a definitive diagnosis (after biopsy) it should be abandoned; and it should not be used to designate carcinoma.2 Leukoplakia has been used to designate epithelial lesions in the mouth which are not white,3 and this has caused confusion. Lesions that are red and eroded in appearance should not be labeled leuko- plakias.
    [Show full text]
  • David W. Jenkins, DPM, FACFAS Professor Arizona School of Podiatric Medicine Midwestern University * *
    * David W. Jenkins, DPM, FACFAS Professor Arizona School of Podiatric Medicine Midwestern University * * *Define verruca plantaris *Review epidemiology of plantar verruca *Review clinical findings for plantar verruca *List a differential diagnosis for plantar verruca *Discuss conservative management of verruca plantaris *Describe the surgical approach to verruca plantaris * *Epidermal lesion *Etiology is the human papilloma virus *High rate of recurrence * * 7-10% prevalence-occur commonly in children and young adults * More common in handlers of meat, fish, poultry * Worse with decreased cell mediated immunity * Spread by skin to skin contact * 2-6 month incubation * More common in whites * Spontaneous remission in up to 2/3 within two years * Recurrence is common * *“rock in shoe” *Corn or callus may have black dots *Slowly growing in size and/or number *May bleed *May be quite tender *Won’t go away *Others in family have this * *Punctate black dots *Lesion very well demarcated *Devoid of skin lines * *Cauliflower appearance *Tenderness to lateral pressure>>> direct pressure *May see satellite lesions *May present in MOSAIC pattern * * * Porokeratosis* * Tyloma (callus)* * Heloma (corn) * Foreign body inclusion cyst * Seborrheic keratosis * Lichen planus * Epidermal nevus * Molluscum contagiosum * Squamous cell carcinoma * Irritated achrocordon * Amelanotic melanoma * Viral eruptions *most commonly confused * *Benign neglect *Topicals Salicylic acid Cantharone Trichloroacetic acid Podophyllin Imiquimod 5-flourouracil *Intralesional
    [Show full text]
  • Corns and Calluses
    Corns and Calluses What’s the problem? A corn is an area of hard, thickened skin that can occur on the top, between, or on the tip of the toes. A callus is similar in nature, but is larger and usually occurs across the ball of the foot, on the heel, or on the outer side of the great toe. How Does it feel? Calluses and corns quite often are due to pressure and bursal sacs (fluid-filled balloons that act as shock absorbers) beneath them, causing symptoms ranging from sharp, shooting pain to dull, aching soreness. How did this happen? Corns and calluses form because of repeated friction and pressure, as a shoe (or ground) rubbing against a bony prominence (bone spur) on the toe or foot. In order to prevent the formation of an open sore of a blister, the skin thickens in response to this pressure. Small amounts of friction or pressure over long periods of time cause a corn or callus. Large amounts of friction or pressure over shorter periods of time cause blisters or open sores. How is it diagnosed? First, your doctor will conduct a thorough inspection of these areas. She may gently trim some of the thickened skin away, in order to rule out a wart. Your doctor may also order some X-rays to identify the specific bone problem that is causing the corn or callus. How can I care for myself? Metabolism, Endocrinology, Diabetes & Podiatry - 1 - Do not try to treat yourself if you are diabetic or have poor circulation. If you cut yourself, you may cause an infection.
    [Show full text]
  • Buffalo Medical Group, P.C. Robert E
    Buffalo Medical Group, P.C. Robert E. Kalb, M.D. Phone: (716) 630-1102 Fax: (716) 633-6507 Department of Dermatology 325 Essjay Road Williamsville, New York 14221 2 FOOT- 1 HAND SYNDROME 2 foot - 1 hand syndrome is a superficial infection of the skin caused by the common athlete's foot fungus. It is quite common for people to have a minor amount of an athlete's foot condition. This would appear as slight scaling and/or itching between the toes. In addition, patients may have thickened toenails as part of the athlete's foot condition. Again the problem on the feet is very common and often patients are not even aware of it. In some patients, however, the athlete's foot fungus can spread to another area of the body. For some strange and unknown reason, it seems to affect only one hand. That is why the condition is called 2 foot - 1 hand syndrome. It is not clear why the problem develops in only one hand or why the right or left is involved in some patients. Fortunately there is very effective treatment to control this minor skin problem. If the problem with the superficial fungus infection is confined to the skin, then a short course of treatment with an oral antibiotic is all that is required. This antibiotic is very safe and normally clears the skin up fairly rapidly. It is often used with a topical cream to speed the healing process. If, however, the fingernails of the affected hand are also involved then a more prolonged course of the antibiotic will be necessary.
    [Show full text]
  • The Effective Management of Hyperkeratosis
    Clinical REVIEW The effective management of hyperkeratosis There are various skin conditions that fall under the umbrella term ‘hyperkeratosis’. and this article looks at the aetiology and subsequent modes of treatment in regards to these conditions. yperkeratosis is an umbrella skin disease of the ichthyosis family, term for a number of skin affecting around 1 in 250,000 people. conditions. It involves a Hthickening of the stratum corneum It involves the clumping of keratin (the outer layer of the skin), often filaments (Freedberg et al, 2003). This 8 Fungal infection associated with a keratin abnormality, is a hereditary disease, the symptoms 8 Hyperkeratosis and is also usually accompanied by an of which are hyperkeratosis, blisters 8 Stratum corneum increase in the granular layer of the and erythema. At birth, the skin of 8 Keratin skin. As the corneum layer normally the individual is entirely covered varies greatly in thickness across with thick, horny, armourlike plates different sites, some experience is that are soon shed, leaving a raw needed to assess minor degrees of surface on which scales then reform. hyperkeratosis (Kumar et al, 2004). Multiple minute digitate This thickening is often the skin’s hyperkeratoses (MMDH) normal protection against rubbing, MMDH is a rare familial or acquired pressure and other forms of irritation, cutaneous eruption of filiform keratosis, causing calluses and corns on the hands typically found across the trunk and and feet or whitish areas inside the extremities. Histopathology, distribution mouth. Other forms of hyperkeratosis and history can distinguish it from occur as part of the skin’s defence other digitate keratoses.
    [Show full text]