Chaudhary VM, Kokate KK - A comprehensive review of Daruharidra ( Aristata). INTERNATIONAL JOURNAL OF RESEARCH IN AYURVEDA AND MEDICAL SCIENCES Review Article (www.ijrams.com) ISSN: 2582-2748 Vol. 1; Issue 2: Oct - Dec 2018

A COMPREHENSIVE REVIEW OF DARUHARIDRA (Berberis Aristata).

Chaudhary Vivek Muralidhar,1* Kokate Krishna Kiran.2 1. M.D. (Dravyaguna), Assistant Professor, Department of Dravyaguna, Sumatibhai Shah Ayurved Mahavidya- laya, Hadapsar, Pune, MS, India. 2. M.D. (Ayurved Siddhant), Consulting Ayurveda Physician, Shashwat Ayurveda Multispeciality Clinic And Panchakarma Center, Bharati Vidyapeet, Pune, MS, India. Received on: 15/09/18; Revised on: 30/09/18; Accepted on: 04/10/18 ABSTRACT Berberis aristata Dc. commonly known as Daruharidra is a popular drug which has been used globally in var- ious systems of Medicine viz. Ayurveda, Homeopathy, Allopathy, Unani. Ayurveda classics and Nighantus clearly mentioned Daruharidra in detail with specific synonyms and therapeutic indications. In Ayurveda it is mainly used Netra Roga,Pandu, Kamala, Kushtha, Mutrakruccha, Pratishyaya, Prameha. Clinical and exper- imental studies shows that it shows antioxidative, antiinflamatory,anticancer, hepatoprotective, immunomodu- latory properties. In this article we tried to compile all the information about Daruharidra mentioned in Ayur- vedic Samhitas, Nighantus and other text. Keywords – Daruharidra, Berberis Aristata, Ayurveda, Unani, Pandu, Prameha, Mutrakruccha, Netra rog, Antioxidative, Antiinflamatory, Hepatoprotective, Pharmacognocy.

1. INTRODUCTION 2. LITERARY REVIEW Berberis aristata DC. commonly known as 2.1. History Daruharidra is a popular drug which has been used globally in various systems of Medicine viz. Ayurve- Knowing the drug from ancient time was the prime da, Homeopathy, Allopathy, Unani. is native to task as, their identification, properties and uses were Himalayas at an elevation of 2000 to 3500 metere explained clearly. This ancient study can be classified and also found in Nilgiri Mountains. In Ayurveda it as follows- is mainly used Netra Roga, Pandu, Kamala, Kushtha, Mutrakruccha, Pratishyaya, Prameha. Clinical and 2.1.1. Veda kala experimental studies shows that it shows antioxida- In Vedic literature, “Kesava paddati” describes tive, antiinflamatory,anticancer, hepatoprotective, “Daruharidra” along with “Haridra” in the manage- immunomodulatory properties. ment of “Khalitya” for topical application.1 Some of the major formulations of Da- 2.1.2. Upanishad and Purana kala ruharidra are Rasanjana, Dashang Lepa, Daryadi Kwath, Mahamanjisthadi Kashayam, Mahayograj During the time of Upanishad, references regarding Guggulu, Khadiradi Vati. In this article Daruharidra Daruharidra have not been found. But in Brahmana is explained in detail by quoting all the references grantha this Daruharidra was found in the name of from Brihatrayis like Charaka Samhita, Sushruta Peetadaru and Haridru.2 Samhita, Ashtanga Sangrha, and Nighantus like Bha- vaprakasha, Raja Nighantu, Dhanvantari Nighantu 2.1.3 Samhita Kala etc, the detailed descriptions regarding the taxonomi- cal classification, macroscopic, microscopic, mor- In Charaka samhita, this drug mentioned in different phology, pharmacological actions are explained in contexts synonyms like Darunisa, Darvi, Daruharid- modern review of the drug. ra etc., totally 79 times we can see in different Sthanas. Similarly in Shushruta Samhita description

*Corresponding Author: Chaudhary Vivek Muralidhar. M.D. (Dravyaguna), Assistant Professor, Department of Dravyaguna, Sumatibhai Shah Ayurved Mahavidya- laya, Hadapsar, Pune, MS, India. Email – [email protected].

153 Chaudhary VM, Kokate KK - A comprehensive review of Daruharidra (Berberis Aristata). INTERNATIONAL JOURNAL OF RESEARCH IN AYURVEDA AND MEDICAL SCIENCES Review Article (www.ijrams.com) ISSN: 2582-2748 Vol. 1; Issue 2: Oct - Dec 2018 of Daruharidra 38 different contexts and in Ashtanga  Rasa: Katu, Tikta hridraya it has explained in 69 different contexts.  Vipak: Katu  Veerya: Ushna 2.1.4. Nighantu Kala  Guna: Ushna, Ruksha This Daruharidra is mentioned in almost all Nighan- 2.6. Modern Review of Daruharidra18 tus like, Dhanvantari Nighantu, Bhavaprakash Nighantu, Madanapala Nighantu, Raja Nighantu  Latin name: Berberis aristata Dc. etc., and they were explained in different Vargas.  Berberis: Belonging to the Berberis family  Aristata: Furnished with an elongated projecting 2.1.5. Aadhunika Kala bristle, in connection with the costa (rib).  Berberidae: From Berberys (Arabic name). Dr. P. V. Sharma explained it as hepatoprotective. In Shaligrama Nighantu, Nighantu Adarsha and in Pri- 2.6.1. Taxonomical Classification ya Nighantu explained under different Vargas. Other authors like Nadakarni, Kirithikar Basu have dealt its  Kingdom: Plantae different aspects like its description, morphology,  Division: Phanerogamea types and therapeutic utility.  Sub-division: Angiospermea  Class: Dicotyledonae 2.2. Gana and Varga  Sub-Class: Polypetalae  Group: Thalamiflorae “Gana and Varga of Daruharidra”3-16 are mentioned  Natural Order: Ranales in detail in Table No. 1.  Family: 2.3. Vernacular Names17  Genus: Berberis  Species: aristata  Arabic: Aargis, Ambarbaris.  Bengali: Daruharidra 2.6.2. Habitat  Bhutia: Tsema This species is native to Nepal, globally distributed  Canarese: Bagisutra in India, Nepal and Bhutan. Within India, it has been  English: Indian Barberry, Tree Turmeric recorded in Jammu & Kashmir, Himachal Pradesh,  Greek: Lykion indikoc Uttar Pradesh, Sikkim between an altitude range  Gujrati: Daruhalad of 2000 - 3500 meters, Madhya Pradesh and Tamil  Hindi: Chitra, Chotra, Dahaldi, Kashmal, Kash- Nadu. mar, Raswat  Kannada: Doddamaradarisina 2.6.3. Characteristic features of family Berberida-  Malayalam: Maradarisina, Maramanjal ceae  Marathi: Daruhalad  Oriya: Daruharidra, Daruhalidi Glabrous herbs or shrubs, sometimes climbing.  Punjabi: Chitra, Kasmal, Simlu, Sumlu, Da- Leaves -Simple or compound, rarely stipulate. Flow- ruhaldi ers -Hermaphrodite or rarely diclinous, regular, axil-  Tamil: Mullukala, Usikkala, Garamenjal lary, solitary or in simple compound , usually  Telgu: Kasturipuspu yellow or white. Sepals - Often petaloid, 3 – 9, in 1 –  Urdu: Darhald 3 whorls. Petals -Equal in number to the sepals or twice as many and like them caduceus. -4 – 2.4. Bheda 8, usually 6, opposite to the petals; filaments free or connate; anthers bursting by two apical valves or According to Nighantu Aadarsh there are two types- longitudinally. Carpel- 1-3, rarely more, distinct, stig-  Kashmal; Found in Nilgiri mountains. ma usually peltate. Fruit- 1-3 berries or capsule, usu-  Chitra: By this variety “Rasut” is prepared and ally indehiscent. the fruits are available in the name of “Jarisht”. 2.6.4. Characteristic features of genus Berberis 2.5. Rasapanchak (Tourni) Linn

154 Chaudhary VM, Kokate KK - A comprehensive review of Daruharidra (Berberis Aristata). INTERNATIONAL JOURNAL OF RESEARCH IN AYURVEDA AND MEDICAL SCIENCES Review Article (www.ijrams.com) ISSN: 2582-2748 Vol. 1; Issue 2: Oct - Dec 2018 Habit – Erect shrubs with yellow wood. Leaves - crystals; broad zone of secondary phloem consist- Simple, alternative or fascicled in the axils of 3 – 5.7 ing of sieve elements and phloem fibers, trav- partial or rarely simple Spines, entire or more often ersed by multi seriate phloem rays; sieve elements spiny toothed. Flowers – Small yellow, solitary fas- found in tangential bands with single to five rows cicled, or in bracteates simple or compound recemes. of phloem fibers, lignified, thick-walled phloem Sepals – 6, petaloid, imbricate in two whorls. Petals fibers having pointed ends, broad secondary xy- – 6, imbricate in two whorls, usually with 2 glands lem consisting of tracheids, xylem vessels, xylem inside at the base. Stamens – 6, free, dehiscing by fibers and traversed by multi seriate xylem rays. ascending valves. Carpel – 1. Fruit – A berry, blue Numerous medium sized xylem vessels distributed or red. throughout xylem region in groups or in singles,

19 groups of radially arranged vessels cylindrical with 2.6.5. Morphology of Berberis aristata Dc rounded or projected at one or both ends with spiral thickening; xylem fibers numerous, lignified, large, Habit – A large deciduous shrub usually 1.8 – 3.6m thick-walled with wide lumen, and pointed tips; mul- high but attaining 4.5m. with stem 20cm. diameter. ti-seriate xylem rays consisting of radially rectangu- Twigs – white to pale yellowish brown in color. lar cells, each ray 30-53 cells high, 8-12 cells wide, Bark – Pale brown, closely deep furrowed, rough in a few ray cells containing brown contents. nature. Leaves – 3.8 to 10 by 1.5to 3.3cm., obo- vate to elliptic in shape, entire margin or toothed, Powder base gradually narrowed, reticulate nerves, glossy dark green above, glossy pale green. Petiole – 0 or Yellow in color, fragments of cork cells, yellow col- distinct up to 4mm. – A simple droop- ored phloem fibers, sieve elements, stone cells in ing , 2.5 – 7.5cm. long, dense-flowered. Pedi- singles or in groups, numerous prismatic crystals cels – Stout, 4 – 6mm. long. Fruit – 7 – 10mm. long, of calcium oxalate, thick-walled lignified xylem ovoid, blue-black with a thick pale bloom; style dis- fibers, xylem vessels having spiral thickening. tinct. Identity, purity and strength22 2.7. Microscopic and Macroscopic structures of Berberis aristata Dc stem  Foreign matter not more than 2 per cent.  Total Ash not more than 14 per cent. 20 2.7.1. Macroscopic  Acid-insoluble ash not more than 5 per cent.  Alcohol-soluble extractive not less than 6 per Length and thickness are variable, bark about 0.4 - cent. 0.8 cm thick, pale yellowish-brown in color, soft,  Water-soluble extractive not less than 8 per cent. deeply furrowed, rough, brittle, xylem portion yel- low with xylem rays, pith mostly absent, when pre- Constituents: sent small, yellowish-brown when dried, fracture short. Berberine, Berbamine, Palmitine, Oxyberberine, Ox- ycanthine, Aromoline. 2.7.2. Microscopic21 2.8. Toxicology23 Cork L.D. 50 value of berberine in mice was found to be Rhytidoma present, cork consisting of 3-45 25mg/kg i.p. Drug was found free from any serious square- rectangular yellow colored, radially ar- toxicity in human being. ranged thin-walled cells, irregular in shape sieve elements , phloem fibers in 1-4 cells arranged in 3. DISCUSSION tangential rows, each fiber spindle-shaped, ligni- fied thick-walled, with wide lumen; all phloem 3.1. Karma ray cells and rhytidoma contain single prismatic Doshghnata of Daruharidra is mentained in Table crystals of calcium oxalate, stone cells present scat- No. 2. tered in phloem ray cells in groups, rarely single, elongated, a few radially arranged rounded, some 3.2. Prayoga of which contain a single prism of calcium oxalate

155 Chaudhary VM, Kokate KK - A comprehensive review of Daruharidra (Berberis Aristata). INTERNATIONAL JOURNAL OF RESEARCH IN AYURVEDA AND MEDICAL SCIENCES Review Article (www.ijrams.com) ISSN: 2582-2748 Vol. 1; Issue 2: Oct - Dec 2018 3.2.1. Netra Roga 3.2.7. Upadamsa  Milk boiled with Daruharidra cooled, mixed Paste of Rasanjana, Shirisha and Haritaki mixed with with little rock salt and should be used for wash- honey should be used. ing eyes or Shunthi rubbed with breast milk and mixed with ghee should be used as collyrium. 3.2.8. Prameha  Decoction made of Darvi 40gms with water 640ml reduced to 1\8th is mixed with honey and Darvi and Amalaki svarasa mixed with honey allevi- used for washing. It is useful in inflammation of ate Prameha In Pistameha, Haridra and Daruharidra eyes caused by all Doshas. decoction is useful.  Decoction of Darvi and Prapaundarika is used as eye drops. 3.3. Pharmacological Action  Rasanjana combined with Trikatu is made into 3.3.1. Anti-inflammatory activity pills which are rubbed and applied as paste.  It destroys (Anjananamika) associated with itch- Aqueous extracts of the roots of B. Aristata in dose ing and inflammation. 500-1000 mg/kg showed significant anti-  In night blindness, Varti made of Rasanjana, inflammatory effect in rats with carrageenan induced Haridra, Daruharidra, leaves of Jati and Nimba paw edema which was compared with that induced by Twak is useful. 10 mg diclofenac sodium.24 Methanolic and aqueous extracts of B. aristata and C. fenestratum have shown 3.2.2. Pandu and Kamala Roga similar anti-inflammatory activity in carrageenan in- Darvighruta: One suffering from Kamala should take duced raw paw edema in rat model.25 cooled decoction of Triphala, Guduchi, Darvi or Nimba mixed with honey in the morning. 3.3.2. Anti-microbial activity 3.2.3. Kushtha The alkaloid berberine from B.aristata showed anti- bacterial effects against trachoma.26 Hydro alcoholic Darvi or Rasanjana taken with Gomutra checks extracts of four Berberis species showed antimicrobi- Kustha. Similarly, Haritaki taken with Trikatu, al activity against eleven bacterial and eight fungal Jaggery and oil for a month it cures Kustha. strain.27 Darvi and Rasanjana, Nimba and Patola, Khadira (heart wood), Aragvadha and Kutaja, Triphala, 3.3.3. Cytotoxic and Anti-tumour Activity Saptaparna, Tinisa and Karavira – This decoction should be used in various ways such as bath, intake, Study of methanolic extracts of B.aristata stem and paste, rubbing, dusting and processing of oil and rhizomes of Hemidesmus indicus on MCF7 breast ghee for alleviation of Kustha. cancer cell line proved that extracts have in vitro cy- Oil cooked with Darvi, Vidanga and Kampillaka is totoxic activity.28 Alcoholic stem extract showed An- useful and in that having predominance of Kapha and tidiabetic activity in Streptozotocin nicotinamide in- in Pitta, Ghrita cooked with Durva juice is effica- duced type 2 diabetic rats.29 cious. 3.3.4. Anti-diarrhoeal activity 3.2.4. Mutrakruccha Berberine from the roots and barks of B.aristata In Pittaja Mutrakrachra Darvi, Amalaki rasa and showed inhibition of secretary response of heat labile Makshika is useful. enterotoxins of Vibrio cholerae and Escherichia coli in rabbit ligated intestinal loop model and infant 3.2.5. Pratishyaya mouse assay.30 Effects of B. aristata showed hypoli- pidemic effects on lipid profile and blood coagulation Dhumapana should be used with Vati made of Dar- in hyperlipidemia induced rabbits.31 Methanol extract vi, Igundi, Danti and Kinhi. of B. aristata was reported to possess potent anti- 3.2.6. Mukha roga osteoporotic activity based on the observations on bone loss, ash content, uterine weight, biomechanical, biochemical and histopathological changes in ovariec- The extract of Darvi with Honey destroys the dis- 32 eases of mouth, disorders of blood and sinus. tomized rats.

156 Chaudhary VM, Kokate KK - A comprehensive review of Daruharidra (Berberis Aristata). INTERNATIONAL JOURNAL OF RESEARCH IN AYURVEDA AND MEDICAL SCIENCES Review Article (www.ijrams.com) ISSN: 2582-2748 Vol. 1; Issue 2: Oct - Dec 2018 3.4. Cultivation and Propagation 7. Pandit Hara Govinda Sastri Editior. Amara Kosa of Amar Simha, Verse 2,4,101-102. Varanasi: Warm moist loamy soil and light shade is prefera- Chaukambha Sanskrit Sansthan, 2006; p. 208. ble, succeeding in thin, dry and shallow soils. Grows well in heavy clay soils. can be pruned 8. P.V Sharma Editor. (1st ed.). Hindi Commen- back quite severely and re-sprout well from the base. tary of Dr. Guru Prasad Sharma on Dhanvantari Seed can be sown when ripe in a cold frame, they Nighantu, Guduchyadi varga, Verse 56-58. Vara- germinate in late winter or early spring. Stored seeds nasi: Chaukambha Orientalia, 1982; p. 26. may require cold stratification and should be sown in 9. Brahmasankara Misra, Shri Rupalalaji Vaisya, a cold frame. After putting seedlings in individual th pots once they are at least 20cm tall, plant them Editors. (9 ed.). Bhavaprakasha Nighantu of out into their permanent positions in late spring or Bhavmishra, Haritakyadi varga, Verse 201-202. early summer. Varanasi: Chaukambha Sanskrit Sansthan, 1999. p. 119. 4. CONCLUSION 10. Ramprasad Patiala Editor. (Reprint ed.). Mada- Daruharidra was used as medicine since Veda, Upan- napala Nighantu of Madanapala, Haritakyadi ishad and Samhita period. Daruharidra possesses Ka- varga, Verse 30. Mumbai: Khemraj Shri tu, Tikta, Kashay Rasa, Katu Vipaka, Ushana Veerya Krishnadas Prakashan, 1998. p. 42 and Laghu and Ruksha properties thus showing 11. Dr. Indradeva Tripathi Editor. (2nd ed.). Raj Pramehaghna, KuShthaghna, Netrya and many more Nighantu of Pandith Narahari, Pippalyadi varga. therapeutic actions. Clinical and experimental studies Verse 7. Varanasi: Krishnadas Academy, 1998; show that it shows antioxidative, anti-inflammatory, p. 135. anticancer, hepatoprotective, immunomodulatory properties. 12. P.V Sharma. Editor. (1st ed.). Hindi Commentary of Dr. Guru Prasad sharma, on Kaiyadev 5. REFERENCES Nighantu of Kaiyadeva, Aushadha Varga, st Verse 1116-1117. Varanasi: Chaukambha Orien- 1. J.L.N. Shastri Editor. (1 ed.). Illustrated Dra- talia, 1979; p. 206. vyaguna Vignana (Vol II). Varanasi: Chukamba Orientalia; 2004. p. 54. 13. Dr. P.V. Sharma. Madhav Dravyaguna Vid- st st nyan. 1 ed. Varanasi: Chowkhamba Vidyabha- 2. Priyavrat Sharma Editor. (1 ed.). Dravyaguna wan, 2004. p. 8. Vijnana (Part–4). Varanasi: Chukambha San- skrit Sansthan; 2012. P. 206-209. 14. S. L. Harishankar Editor (1st ed.), Shaligrama Nighantu of Shaligrama Vaishya, Ashta varga. 3. Vaidya Yadavji Trikramji Acharya Editor, Mumbai: Khemraj Shri Krishnadas Prakashan, (Reprint ed.) Charaka Samhita of Charaka, Sutra 1997; p. 160. Sthana; Chapter 4, Verse 9-11. Varanasi: Chaukambha Sanskrith Samsthana, 2004; p. 32. 15. P. V. Sharma Editor. (1st ed.). Priya Nighantu, th Shatapushpadi Varga, Verse 172. Varanasi: 4. Vaidya Yadavji Trikramjim Acharya Editor. (8 Chaukambha Surabharati Prakashan, 1983; p. ed.). Sushrutha Samhita of Sushruta, Suthra 108. Sthana; Chapter 38. Verse 53-64. Varanasi: Chaukambha Orientalia, 2005; p. 166-169. 16. Vaidya Bapalal. Nighantu Adarsha, Uttarardha. rd th 3 ed. Daruharidradi Varga. Varanasi: 5. Vaidya Yadunandana Upadhyaya editor. (14 Chaukambha Bharati academy, 2002; p. 48. ed.). Ashtanga Hridaya of Vagbhata, Suthra sthana; Chapter 15, Verse 35-40. Varanasi: 17. Ibidem 16, Uttarardha, Daruharidradi Varga. p. Chaukambha Sanskrit Sansthan, 2003; p. 106- 48. 107. 18. K. R, Kiritikar, B.D. Basu, Indian Medicinal 6. Dr. P. V. Sharma Editor. (1st ed.). The Astanga Plants, Vol 1. (2nd ed.). In: Dehradun: E. Blatter Nighantu of Acharya Vahata. Madras: Kup- and J. F. Caius, Editors. International Book Dis- pusawamy Sastri Research Institute, 1973; p. 20. tributors, 1999; p. 100.

157 Chaudhary VM, Kokate KK - A comprehensive review of Daruharidra (Berberis Aristata). INTERNATIONAL JOURNAL OF RESEARCH IN AYURVEDA AND MEDICAL SCIENCES Review Article (www.ijrams.com) ISSN: 2582-2748 Vol. 1; Issue 2: Oct - Dec 2018 19. Ibidem 18, p. 101. Int Trach Pathol Ocul Trop Subtrop Sante Publique. 1992; 69: 147–165. 20. Ibidem 18, p. 102. 27. S Meenakshi, S Shrivastava, AKS Rawat. Anti- 21. Anonymous, Ayurvedic Pharmacopoeia of India, microbial activities of Indian Berberis species. Part I - Vol 3. 1st ed. New Delhi: Ministry of Fitoterapia, 2007; 78 (7-8): 574-576. Health and Family Welfare, Govt. of India, 1999. p. 34-35. 28. PM Mazumder, S Das, MK Das. Cytotoxic activi- th ty of methanolic extracts of Berberis aristata DC 22. K.R. Khandelwal. Practical Pharmacognosy. 13 and Hemidesmus indicus R.Br. in MCF7 Cell ed. Pune: Nirali Prakashan, 2005. p. 12-16. Line. Journal of Current Pharmaceutical Re- 23. Toxicology, Available from, http://www.pfaf.org/ search. 2011; 01: 12-15. database/plants.php?Berberia+aristata. Last ac- 29. A Shirwaikar, K Rajendran, ISR Punitha. J Eth- cessed on 24.10.17. anopharmacol. 2005; 97: 369-374. 24. N Rajput, JM Nigam, DN Srivastava, YP Sahni. 30. Sack PB, Froehlich JL. Berberine inhibits intesti- Anti-inflammatory activity of Adhatoda vasica nal secretory response of Vibrio cholerae and and Berberis aristata on carrageenan induced paw Escherichia coli enterotoxins. Infect Immun. oedema in rats. Journal of Natural Remedies 1982; 35(2): 353-365. 2004; 4(1): 97– 102. 31. FA Razzaq, RA Khan, Z Feroz, S Afroz. Effect 25. S Sekhar, R Karmakar, KK Ramachandra, SN of Berberis aristata on lipid profile and coagula- Ramachandrappa, HS Prakash. Potential anti- tion parameters. African Journal of Pharmacy and inflammatory bio-actives from medicinal plants Pharmacology 2011; 5(7): 943 – 947. of Western Ghats, India. Pharmacognosy Com- munications. 2012; 2(2): 2-12. 32. HS Yogesh, VM Chandrashekhar, HR Katti. Anti -osteoporotic activity of aqueous methanol ex- 26. PK Khosla, VI Neeraj, SK Gupta, G Satpathy. tract of Berberis aristata in Ovariectomized rats. J Berberine, A potential drug for Trachoma. Rev Ethnopharmacol. 2011; 24(134[2]): 334-8.

6. TABLES

Sr. No. Samhita Gana / Varga 1 Charak Samhita Lekhaniya3, Kushtagna3, Kandughna3, Arshogna.3 4 4 4 2 Sushrut Samhita Vachaharidradi , Mustadi , Lakshadi 3 Ashtang Sangraha Vachaharidradi5, Mustadi5 6 4 Ashtanga Nighantu Vachadi, Haridradi 5 Amara Kosh Vanaushadi7 8 6 Dhanvantari Nighantu Guduchyadi

7 Bhavprakash Nighantu Haritakyadi9 8 Madanpala Nighantu Vividhaushadi10 11 9 Raja Nighantu Pippalyadi 10 Kaiyadeva Nighantu Oushadhi12 13 11 Madhav Dravyaguna Vividoushadhi 12 Shaligram Nighantu Ashtvarga14

13 Priya Nighantu 15 Shatpushpadi 14 Nighantu Aadarsh Daruharidradi16

Table No. 1. Gana and Varga of Daruharidra. 158 Chaudhary VM, Kokate KK - A comprehensive review of Daruharidra (Berberis Aristata). INTERNATIONAL JOURNAL OF RESEARCH IN AYURVEDA AND MEDICAL SCIENCES Review Article (www.ijrams.com) ISSN: 2582-2748 Vol. 1; Issue 2: Oct - Dec 2018

Sr. Samhita Doshaghnata

No. Vatahara Pittahara Kaphahara

1 Sushruta Samhita - + +

2 Ashtang Hriday + - + 3 Shaligram Nighantu - - +

4 Nighantu Adarsha + - +

5 Nhavprakash Nighantu - + + 6 Madanpal Nighantu - + +

7 Kaiyadev Nighantu - + +

8 Madhav Dravyaguna + - + 9 Priya Nighantu - + +

10 Dhanvantari Nighantu - + +

Table No. 2. Doshaghnata of Daruharidra.

Cite this article as: Chaudhary VM, Kokate KK. A comprehensive review of Daruharidra (Berberis Aristata). International Jour- nal of Research in Ayurveda and Medical Sciences 2018; 1 (2): 153-159.

Source of Support: Nil; Conflict of Interest: None declared.

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