The Encyclopedia of Mind Control
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Anti-Cholinergic Alkaloids As Potential Therapeutic Agents for Alzheimer's Disease
Indian Journal of Biochemistry & Biophysics Vol. 50, April 2013, pp. 120-125 Anti-cholinergic alkaloids as potential therapeutic agents for Alzheimer’s disease: An in silico approach Huma Naaz, Swati Singh, Veda P Pandey, Priyanka Singh and Upendra N Dwivedi* Bioinformatics Infrastructure Facility, Center of Excellence in Bioinformatics, Department of Biochemistry, University of Lucknow, Lucknow 226 007, India Received 10 September 2012; revised 25 January 2013 Alzheimer’s disease (AD), a progressive neurodegenerative disorder with many cognitive and neuropsychiatric symptoms is biochemically characterized by a significant decrease in the brain neurotransmitter acetylcholine (ACh). Plant-derived metabolites, including alkaloids have been reported to possess neuroprotective properties and are considered to be safe, thus have potential for developing effective therapeutic molecules for neurological disorders, such as AD. Therefore, in the present study, thirteen plant-derived alkaloids, namely pleiocarpine, kopsinine, pleiocarpamine (from Pleiocarpa mutica, family: Annonaceae), oliveroline, noroliveroline, liridonine, isooncodine, polyfothine, darienine (from Polyalthia longifolia, family: Apocynaceae) and eburnamine, eburnamonine, eburnamenine and geissoschizol (from Hunteria zeylanica, family: Apocynaceae) were analyzed for their anti-cholinergic action through docking with acetylcholinesterase (AChE) as target. Among the alkaloids, pleiocarpine showed promising anti-cholinergic potential, while its amino derivative showed about six-fold -
5994392 Tion of Application No. 67375.734 Eb3-1685, PEN. T
USOO5994392A United States Patent (19) 11 Patent Number: 5,994,392 Shashoua (45) Date of Patent: Nov.30, 1999 54 ANTIPSYCHOTIC PRODRUGS COMPRISING 5,120,760 6/1992 Horrobin ................................. 514/458 AN ANTIPSYCHOTICAGENT COUPLED TO 5,141,958 8/1992 Crozier-Willi et al. ................ 514/558 AN UNSATURATED FATTY ACID 5,216,023 6/1993 Literati et al. .......................... 514/538 5,246,726 9/1993 Horrobin et al. ....................... 424/646 5,516,800 5/1996 Horrobin et al. ....................... 514/560 75 Inventor: Victor E. Shashoua, Brookline, Mass. 5,580,556 12/1996 Horrobin ................................ 424/85.4 73 Assignee: Neuromedica, Inc., Conshohocken, Pa. FOREIGN PATENT DOCUMENTS 30009 6/1981 European Pat. Off.. 21 Appl. No.: 08/462,820 009 1694 10/1983 European Pat. Off.. 22 Filed: Jun. 5, 1995 09 1694 10/1983 European Pat. Off.. 91694 10/1983 European Pat. Off.. Related U.S. Application Data 59-025327 2/1984 Japan. 1153629 6/1989 Japan. 63 Continuation of application No. 08/080,675, Jun. 21, 1993, 1203331 8/1989 Japan. abandoned, which is a continuation of application No. 07/952,191, Sep. 28, 1992, abandoned, which is a continu- (List continued on next page.) ation of application No. 07/577,329, Sep. 4, 1990, aban doned, which is a continuation-in-part of application No. OTHER PUBLICATIONS 07/535,812,tion of application Jun. 11, No. 1990, 67,375.734 abandoned, Eb3-1685, which is a continu-PEN. T. Higuchi et al. 66 Prodrugs as Noye Drug Delivery Sys 4,933,324, which is a continuation-in-part of application No. -
THE TAKING of AMERICA, 1-2-3 by Richard E
THE TAKING OF AMERICA, 1-2-3 by Richard E. Sprague Richard E. Sprague 1976 Limited First Edition 1976 Revised Second Edition 1979 Updated Third Edition 1985 About the Author 2 Publisher's Word 3 Introduction 4 1. The Overview and the 1976 Election 5 2. The Power Control Group 8 3. You Can Fool the People 10 4. How It All BeganÐThe U-2 and the Bay of Pigs 18 5. The Assassination of John Kennedy 22 6. The Assassinations of Robert Kennedy and Dr. Martin Luther King and Lyndon B. Johnson's Withdrawal in 1968 34 7. The Control of the KennedysÐThreats & Chappaquiddick 37 8. 1972ÐMuskie, Wallace and McGovern 41 9. Control of the MediaÐ1967 to 1976 44 10. Techniques and Weapons and 100 Dead Conspirators and Witnesses 72 11. The Pardon and the Tapes 77 12. The Second Line of Defense and Cover-Ups in 1975-1976 84 13. The 1976 Election and Conspiracy Fever 88 14. Congress and the People 90 15. The Select Committee on Assassinations, The Intelligence Community and The News Media 93 16. 1984 Here We ComeÐ 110 17. The Final Cover-Up: How The CIA Controlled The House Select Committee on Assassinations 122 Appendix 133 -2- About the Author Richard E. Sprague is a pioneer in the ®eld of electronic computers and a leading American authority on Electronic Funds Transfer Systems (EFTS). Receiving his BSEE degreee from Purdue University in 1942, his computing career began when he was employed as an engineer for the computer group at Northrup Aircraft. He co-founded the Computer Research Corporation of Hawthorne, California in 1950, and by 1953, serving as Vice President of Sales, the company had sold more computers than any competitor. -
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Botany and Ecology DIPLOMA TH
Charles University in Prague, Faculty of Pharmacy In Hradec Kralove Department of Pharmaceutical Botany and Ecology ______________________________________________________________________ DIPLOMA THESIS Biological Activity of Plant Metabolites XVII. Alkaloids of Corydalis yanhusuo W.T. Wang Supervisor of Diploma Work: Assoc. Prof. RNDr. Lubomir Opletal, CSc. Head of Department: Prof. RNDr. Luděk Jahodář, CSc. Hradec Králové April, 2011 Gabriella Cipra Declaration I declare that this thesis is my original copyrighted work. All literature and other sources from which I extracted my research in the process are listed in the bibliography and all work is properly cited. This work has not been used to gain another or same title. Acknowledgements I wish to express my deepest gratitude, first and foremost to Assoc. Prof. RNDr. Lubomír Opletal, CSc. for all his guidance, support and enthusiasm with the preparation of this thesis. I would also like to thank the Department of Pharmaceutical Botany and Ecology for the pleasant working environment, as well as Assoc. Prof. PharmDr. Jiří Kuneš, Ph.D. for preparation and interpretation of NMR spectra, Ing. Kateřina Macáková for biological activity measurements, and Ing. Lucie Cahlíková, Ph.D. for MS spectra measurements and interpretations. This work was financially supported by Specific University Research Foundation No SVV-2011-263002 (Study of biologically active compounds in prespective of their prevention and treatment in civil diseases) Table of Contents 1 INTRODUCTION 7 2 AIM OF WORK 10 3 THEORETICAL -
Analysis of L-Dopa Induced Dyskinesias in 51 Patients with Parkinsonism
J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.34.6.668 on 1 December 1971. Downloaded from J. Neurol. Neurosurg. Psychiat., 1971, 34, 668-673 Analysis of L-dopa induced dyskinesias in 51 patients with Parkinsonism R. J. MONES, T. S. ELIZAN, AND G. J. SIEGEL From the Department of Neurology, Mount Sinai Medical School, New York, New York, U.S.A. SUMMARY An analysis of 51 patients with Parkinsonism who have developed L-dopa induced dyskinesias is presented. The cause has not been proven, although various hypotheses are discussed. One third of the total number of patients treated developed dyskinesia. These patients tend to re- spond better to L-dopa than the other group. There is a tendency for the older patient or the patient with long-standing disease to develop dyskinesias. There appears to be no way of predicting which patients will develop dyskinesia by analysis of the symptoms or the aetiology of the Parkinsonism syndrome. The unilateral characteristic of the dyskinesia in patients with hemi-Parkinsonism and patients with unilateral thalamotomies suggests that structural abnormalities are critical in deter-guest. Protected by copyright. mining the presence and localization of dyskinesias. This is supported by non-occurrence of similarly treated patients without Parkinsonism. L-dopa is now established as the treatment of choice and 45 started in the hospital. The protocol for the medical for Parkinsonism. Many articles have appeared in and neurological evaluation of these patients, the follow- the literature since the initial work of Cotzias, up care, and the laboratory data are included in a pre- Van vious paper (Mones, 1969). -
Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Sedative
Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Sedative Chemical Dosage (+)-BORNYL-ISOVALERATE -- (-)-DICENTRINE LD50=187 1,8-CINEOLE -- 2-METHYLBUT-3-ENE-2-OL -- 6-GINGEROL -- 6-SHOGAOL -- ACYLSPINOSIN -- ADENOSINE -- AKUAMMIDINE -- ALPHA-PINENE -- ALPHA-TERPINEOL -- AMYL-BUTYRATE -- AMYLASE -- ANEMONIN -- ANGELIC-ACID -- ANGELICIN ED=20-80 ANISATIN 0.03 mg/kg ANNOMONTINE -- APIGENIN 30-100 mg/kg ARECOLINE 1 mg/kg ASARONE -- ASCARIDOLE -- ATHEROSPERMINE -- BAICALIN -- BALDRINAL -- BENZALDEHYDE -- BENZYL-ALCOHOL -- Chemical Dosage BERBERASTINE -- BERBERINE -- BERGENIN -- BETA-AMYRIN-PALMITATE -- BETA-EUDESMOL -- BETA-PHENYLETHANOL -- BETA-RESERCYCLIC-ACID -- BORNEOL -- BORNYL-ACETATE -- BOSWELLIC-ACID 20-55 mg/kg ipr rat BRAHMINOSIDE -- BRAHMOSIDE -- BULBOCAPNINE -- BUTYL-PHTHALIDE -- CAFFEIC-ACID 500 mg CANNABIDIOLIC-ACID -- CANNABINOL ED=200 CARPACIN -- CARVONE -- CARYOPHYLLENE -- CHELIDONINE -- CHIKUSETSUSAPONIN -- CINNAMALDEHYDE -- CITRAL ED 1-32 mg/kg CITRAL 1 mg/kg CITRONELLAL ED=1 mg/kg CITRONELLOL -- 2 Chemical Dosage CODEINE -- COLUBRIN -- COLUBRINOSIDE -- CORYDINE -- CORYNANTHEINE -- COUMARIN -- CRYOGENINE -- CRYPTOCARYALACTONE 250 mg/kg CUMINALDEHYDE -- CUSSONOSIDE-A -- CYCLOSTACHINE-A -- DAIGREMONTIANIN -- DELTA-9-THC 10 mg/orl/man/day DESERPIDINE -- DESMETHOXYANGONIN 200 mg/kg ipr DIAZEPAM 40-200 ug/lg/3-4x/day DICENTRINE LD50=187 DIDROVALTRATUM -- DIHYDROKAWAIN -- DIHYDROMETHYSTICIN 60 mg/kg ipr DIHYDROVALTRATE -- DILLAPIOL ED50=1.57 DIMETHOXYALLYLBENZENE -- DIMETHYLVINYLCARBINOL -- DIPENTENE -
`The Primary Emotions Were Exhaustion and Fear'
`The Primary Emotions THE WASHINGTON POST Tuesday, November 21,1978 A15 Were Exhaustion and Fear' Deborah Layton Blakey, 25, was a top punishment for defection was death. The aide of the Rev. Jim Jones until May, when fact that severe corporal punishment was she asked American consul officials to safe- frequently administered to temple members guard her departure from the Peoples Tem- gave the threats a frightening air of reality. ple jungle outpost in Guyana. In the follow. The Rev. Jones saw himself as the center ing June 15, 1978, affidavit given to her of a conspiracy. The identity of the con- lawyer for potential action, she detailed. spirators changed from day to day along conditions at the agricultural mission, say- with his erratic world vision. He induced ing Jones had become a "paranoid" ob- the fear in others that, through their contact sessed with "traitors." Spokesmen for the with him, they had become targets of the temple categorically denied her charges at conspiracy. He convinced black temple mem- the time. bers that if they did not follow him to The purpose of this affidavit is to call Guyana they would be put into concentra- tion camps and killed. White members were to the attention of the United States govern- instilled with the belief that their names ap- ment the existence of a situation which peared on a secret list of enemies of the threatens, the lives of United States citizens state that was kept by the CIA and that they living in Jonestown, Guyana. would be tracked down, tortured, impris- oned' and subsequently killed, if they did From August• 1971 until May 13, 1978, I not flee to Guyana. -
The Black Panther Party Under Attack
UE DI IPV DIUTUED 25 r :~" NIS THt BUM rANIntn cents Black Community News Service VOL. III NO. 20 SATURDAY SEPTEMBER 6, 1969 PUBLISHED MINISTRY OF INFORMATION THE BLACK PANTHER PARTY BOX 2967, CUSTOM HOUSE WEEKLY SAN FRANCISCO, CA 94126 THE BLACK PANTHER, SATURDAY SEPTEMBER 6, 1969 PAGE 2 ENEMIES "WITHIN" ENEMIES Cultural nationalism is a trick ganization, this is also a part of Haiti, and that the oppressor is long rapping and standing on the barbituates to the young people in used by the black bourgeoisie and the plan of the continuation of very shrewd in that manner be corner and waving our hands and our community, they can survive in the children of the bourgeoisie. Nixon's program referred to as cause racism, black racism, cul swaying and trying to style, I this system by joining certain or They tell brothers to love every black capitalism. The cultural na tural nationalism, black capitalism don't mean that kind of education, ganizations that come under the po thing black and to have an undying tionalists take the position that all these things are just the in I mean the kind of education that litical standards of the system like love for blacks, while they jockey capitalism isn't bad, it was only bad gredients, just the kind of ingred has put America up against the the US organization, the N.A for positions, executive positions because blacks never had a chance ients that's necessary to create a wall the kind of education that was A.C.P., the Black Muslims all of on Richard Nixon's black capi to excel or that they never had a Haiti within the black communities exemplified by the two courageous these organizations that's not talist program. -
An FBI Message Sheet Dated 3-28-93 Discussing What to Do in Response to a Letter from a Lawyer Who Once Represented Jim Jones
To:[email protected] Subject:(no subject) CC: Date:Wed, 08 Oct 2003 14:18:39 -0500 Status:Normal From:Lee Hancock <[email protected]> [saveaddr-1236] Reply-to:Lee Hancock [saveaddrbook-1236] <[email protected]> Cathy - Last email for a while. Promise. But I ran across this while rummaging through electronic files. I can't give you any information on how I came across it, but can tell you that I got access in the late 90s to number of FBI internal documents on the Davidian siege and aftermath. Time and logistical constraints allowed me only to take notes on much of what I saw. I took them copiously, often copying document contents verbatim onto my laptop. Among the sea of records I slogged through was an FBI Message sheet dated 3-28-93 discussing what to do in response to a letter from a lawyer who once represented Jim Jones. The letter, also in the records, warned that the FBI's tactics will lead to disaster. Here's what it said, w/ any of my notes placed in {} I just thought this would be of particular interest. I found it fascinating at the time I stumbled across it but never found the proper venue to write about it. Had I ever done a book on the Waco debacle, I would've definitely included it. Let me know what you think. Lee Here's the Jones' lawyer document: FBI Message Sheet Date: 3-28-93 From: San Antonio: Rigler Synopsis: Lawyer for Jim Jones of Jonestown suicide volunteers Details: SA George Houston, FBI San Francisco, called re: conversation with Timothy Stoen who was attorney for Jim Jones. -
Extraordinary Encounters: an Encyclopedia of Extraterrestrials and Otherworldly Beings
EXTRAORDINARY ENCOUNTERS EXTRAORDINARY ENCOUNTERS An Encyclopedia of Extraterrestrials and Otherworldly Beings Jerome Clark B Santa Barbara, California Denver, Colorado Oxford, England Copyright © 2000 by Jerome Clark All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, except for the inclusion of brief quotations in a review, without prior permission in writing from the publishers. Library of Congress Cataloging-in-Publication Data Clark, Jerome. Extraordinary encounters : an encyclopedia of extraterrestrials and otherworldly beings / Jerome Clark. p. cm. Includes bibliographical references and index. ISBN 1-57607-249-5 (hardcover : alk. paper)—ISBN 1-57607-379-3 (e-book) 1. Human-alien encounters—Encyclopedias. I. Title. BF2050.C57 2000 001.942'03—dc21 00-011350 CIP 0605040302010010987654321 ABC-CLIO, Inc. 130 Cremona Drive, P.O. Box 1911 Santa Barbara, California 93116-1911 This book is printed on acid-free paper I. Manufactured in the United States of America. To Dakota Dave Hull and John Sherman, for the many years of friendship, laughs, and—always—good music Contents Introduction, xi EXTRAORDINARY ENCOUNTERS: AN ENCYCLOPEDIA OF EXTRATERRESTRIALS AND OTHERWORLDLY BEINGS A, 1 Angel of the Dark, 22 Abductions by UFOs, 1 Angelucci, Orfeo (1912–1993), 22 Abraham, 7 Anoah, 23 Abram, 7 Anthon, 24 Adama, 7 Antron, 24 Adamski, George (1891–1965), 8 Anunnaki, 24 Aenstrians, 10 Apol, Mr., 25 -
Kenn Thomas Papers (S1195)
PRELIMINARY INVENTORY S1195 (SA3811, SA3812, SA4367) KENN THOMAS PAPERS This collection is available at The State Historical Society of Missouri. If you would like more information, please contact us at [email protected]. Introduction Approximately 44 cubic feet The papers of Kenn Thomas contain correspondence, business files, travel records, a collection of independently produced, small press fanzines, audio/visual recordings, and subject files documenting the assassination of John F. Kennedy, the Iran-Contra scandal, and Unidentified Flying Objects. Other materials of interest include video and audio recordings of Bob Dylan and the Band, performing in St. Louis area venues. The papers date from 1970 to 2007. Kenn Thomas was born on June 12, 1958, in St. Louis City, Missouri. Thomas began his career as a freelance writer in the 1980s as a rock music critic for the St. Louis Post- Dispatch, the St. Louis Globe-Democrat and the Riverfront Times. He also produced and hosted a radio program focusing on the Beat era writers, Off The Beaten Path (later retitled Offbeat) for KDHX community-based radio. In 1988 he launched a magazine, Steamshovel Press, to publicize his unpublished music reviews and interviews with notable pop-culture icons, including Amiri Baraka and Ram Dass (Richard Alpert). Thomas’s lifelong fascination with conspiracy theories prompted him to shift the magazine’s focus in 1992 to examine conspiracy theories and their sociological dimension in popular culture. Steamshovel Press soon gained notice and wider distribution in conspiracy circles. Three back issue anthologies eventually were published: Popular Alienation (Illuminet, 1995), Popular Paranoia (Adventures Unlimited Press, 2002); and Parapolitics: Conspiracy in Contemporary America (AUP, 2006). -
The Case Against Mark Lane
•'-//3/ 7 '' 7 Date Page The Case Against Mark Lane The conclusion: He has only two motives—profit and headlines by Steven Brill t is pounding rain on 101 going north of San Francis- intelligence agencies and how the confrontation with Jones [and co, and Mark Lane's Hertz Toyota is not taking it Congressman Leo Ryan] was arranged by them." well. The wind, the splash, the tin grind of the motor, In the months following Guyana, we will be hearing from him nearly drown out his voice—a voice that is at the again. Not in his early Toyota monotone. But with the practiced beginning of our 120-mile, three-and-a-half-hour drive hysteria that I'll see later in our ride—the .kind that's wowed surprisingly subdued. We are on our way from the them on campuses before, when the subject was death and the San Francisco airport to Santa Rosa, 60 miles north, dead were John Kennedy and Martin Luther King Jr. And where Lane, he says, needs to interview a potential always the adjective lawyer will come in front of his name. witness in the Guyana suicide case. As we go, I keep an eye out Lawyer Mark Lane today charged that ... Lawyer Mark Lane for a rent-a-car billboard. Should he explode when I start asking revealed ... Lawyer Mark Lane attacked.... questions, I'll need a way back. Don't believe him. On major issues, Mark Lane is as utterly I expect a raving conspiracy addict, a foamer at the mouth.