Natural Experiments in the Social Sciences
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The Practice of Causal Inference in Cancer Epidemiology
Vol. 5. 303-31 1, April 1996 Cancer Epidemiology, Biomarkers & Prevention 303 Review The Practice of Causal Inference in Cancer Epidemiology Douglas L. Weedt and Lester S. Gorelic causes lung cancer (3) and to guide causal inference for occu- Preventive Oncology Branch ID. L. W.l and Comprehensive Minority pational and environmental diseases (4). From 1965 to 1995, Biomedical Program IL. S. 0.1. National Cancer Institute, Bethesda, Maryland many associations have been examined in terms of the central 20892 questions of causal inference. Causal inference is often practiced in review articles and editorials. There, epidemiologists (and others) summarize evi- Abstract dence and consider the issues of causality and public health Causal inference is an important link between the recommendations for specific exposure-cancer associations. practice of cancer epidemiology and effective cancer The purpose of this paper is to take a first step toward system- prevention. Although many papers and epidemiology atically reviewing the practice of causal inference in cancer textbooks have vigorously debated theoretical issues in epidemiology. Techniques used to assess causation and to make causal inference, almost no attention has been paid to the public health recommendations are summarized for two asso- issue of how causal inference is practiced. In this paper, ciations: alcohol and breast cancer, and vasectomy and prostate we review two series of review papers published between cancer. The alcohol and breast cancer association is timely, 1985 and 1994 to find answers to the following questions: controversial, and in the public eye (5). It involves a common which studies and prior review papers were cited, which exposure and a common cancer and has a large body of em- causal criteria were used, and what causal conclusions pirical evidence; over 50 studies and over a dozen reviews have and public health recommendations ensued. -
Statistics and Causal Inference (With Discussion)
Applied Statistics Lecture Notes Kosuke Imai Department of Politics Princeton University February 2, 2008 Making statistical inferences means to learn about what you do not observe, which is called parameters, from what you do observe, which is called data. We learn the basic principles of statistical inference from a perspective of causal inference, which is a popular goal of political science research. Namely, we study statistics by learning how to make causal inferences with statistical methods. 1 Statistical Framework of Causal Inference What do we exactly mean when we say “An event A causes another event B”? Whether explicitly or implicitly, this question is asked and answered all the time in political science research. The most commonly used statistical framework of causality is based on the notion of counterfactuals (see Holland, 1986). That is, we ask the question “What would have happened if an event A were absent (or existent)?” The following example illustrates the fact that some causal questions are more difficult to answer than others. Example 1 (Counterfactual and Causality) Interpret each of the following statements as a causal statement. 1. A politician voted for the education bill because she is a democrat. 2. A politician voted for the education bill because she is liberal. 3. A politician voted for the education bill because she is a woman. In this framework, therefore, the fundamental problem of causal inference is that the coun- terfactual outcomes cannot be observed, and yet any causal inference requires both factual and counterfactual outcomes. This idea is formalized below using the potential outcomes notation. -
Natural Experiments
Natural Experiments Jason Seawright [email protected] August 11, 2010 J. Seawright (PolSci) Essex 2010 August 11, 2010 1 / 31 Typology of Natural Experiments J. Seawright (PolSci) Essex 2010 August 11, 2010 2 / 31 Typology of Natural Experiments Classic Natural Experiment J. Seawright (PolSci) Essex 2010 August 11, 2010 2 / 31 Typology of Natural Experiments Classic Natural Experiment Instrumental Variables-Type Natural Experiment J. Seawright (PolSci) Essex 2010 August 11, 2010 2 / 31 Typology of Natural Experiments Classic Natural Experiment Instrumental Variables-Type Natural Experiment Regression-Discontinuity Design J. Seawright (PolSci) Essex 2010 August 11, 2010 2 / 31 Bolstering Understand assumptions. J. Seawright (PolSci) Essex 2010 August 11, 2010 3 / 31 Bolstering Understand assumptions. Explore role of qualitative evidence. J. Seawright (PolSci) Essex 2010 August 11, 2010 3 / 31 Classic Natural Experiment J. Seawright (PolSci) Essex 2010 August 11, 2010 4 / 31 Classic Natural Experiment 1 “Nature” randomizes the treatment. J. Seawright (PolSci) Essex 2010 August 11, 2010 4 / 31 Classic Natural Experiment 1 “Nature” randomizes the treatment. 2 All (observable and unobservable) confounding variables are balanced between treatment and control groups. J. Seawright (PolSci) Essex 2010 August 11, 2010 4 / 31 Classic Natural Experiment 1 “Nature” randomizes the treatment. 2 All (observable and unobservable) confounding variables are balanced between treatment and control groups. 3 No discretion is involved in assigning treatments, or the relevant information is unavailable or unused. J. Seawright (PolSci) Essex 2010 August 11, 2010 4 / 31 Classic Natural Experiment 1 “Nature” randomizes the treatment. 2 All (observable and unobservable) confounding variables are balanced between treatment and control groups. -
Bayesian Causal Inference
Bayesian Causal Inference Maximilian Kurthen Master’s Thesis Max Planck Institute for Astrophysics Within the Elite Master Program Theoretical and Mathematical Physics Ludwig Maximilian University of Munich Technical University of Munich Supervisor: PD Dr. Torsten Enßlin Munich, September 12, 2018 Abstract In this thesis we address the problem of two-variable causal inference. This task refers to inferring an existing causal relation between two random variables (i.e. X → Y or Y → X ) from purely observational data. We begin by outlining a few basic definitions in the context of causal discovery, following the widely used do-Calculus [Pea00]. We continue by briefly reviewing a number of state-of-the-art methods, including very recent ones such as CGNN [Gou+17] and KCDC [MST18]. The main contribution is the introduction of a novel inference model where we assume a Bayesian hierarchical model, pursuing the strategy of Bayesian model selection. In our model the distribution of the cause variable is given by a Poisson lognormal distribution, which allows to explicitly regard discretization effects. We assume Fourier diagonal covariance operators, where the values on the diagonal are given by power spectra. In the most shallow model these power spectra and the noise variance are fixed hyperparameters. In a deeper inference model we replace the noise variance as a given prior by expanding the inference over the noise variance itself, assuming only a smooth spatial structure of the noise variance. Finally, we make a similar expansion for the power spectra, replacing fixed power spectra as hyperparameters by an inference over those, where again smoothness enforcing priors are assumed. -
The Distribution of Information in Speculative Markets: a Natural Experiment∗
The Distribution of Information in Speculative Markets: A Natural Experiment∗ Alasdair Brown† University of East Anglia June 9, 2014 ∗I would like to thank an associate editor, two anonymous referees, Fuyu Yang, and seminar participants at UEA for comments on this work. All remaining errors are my own. †School of Economics, University of East Anglia, Norwich, NR4 7TJ. Email: [email protected] 1 1 Introduction Abstract We use a unique natural experiment to shed light on the distribution of information in speculative markets. In June 2011, Betfair - a U.K. betting exchange - levied a tax of up to 60% on all future profits accrued by the top 0.1% of profitable traders. Such a move appears to have driven at least some of these traders off the exchange, taking their information with them. We investigate the effect of the new tax on the forecasting capacity of the exchange (our measure of the market’s incorporation of information into the price). We find that there was scant decline in the forecasting capacity of the exchange - relative to a control market - suggesting that the bulk of information had hitherto been held by the majority of traders, rather than the select few affected by the rule change. This result is robust to the choice of forecasting measure, the choice of forecasting interval, and the choice of race type. This provides evidence that more than a few traders are typically involved in the price discovery process in speculative markets. JEL Classification: G14, G19 Keywords: informed trading, natural experiment, betting markets, horse racing 1 Introduction There is a common perception that the benefits of trading in speculative assets are skewed towards those on the inside of corporations, or those that move in the same circles as the corporate elite. -
The Visser Chronicles
1 Animorphs Chronicles 3 Visser K.A. Applegate *Converted to EBook by asmodeus *edited by Dace k 2 Prologue “Honey?” No answer. My husband was watching a game on television. He was preoccupied. “Honey?” I repeated, adding more urgency to my tone of voice. He looked over. Smiled sheepishly. “What’s up?” “Marco’s fever is down. I think he’s basically over this thing. He’s asleep. Anyway, I was thinking of getting some fresh air.” He muted the television. “Good idea. It’s tough when they’re sick, huh? Kids. He’s okay, though, huh?” “It’s just a virus.” “Yeah, well, take some time, you’ve been carrying the load. And if you’re going to the store- “ “Actually, I think I’ll go down to the marina.” He laughed and shook his head. “Ever since you bought that boat… I think Marco has some competition as the favorite child in this household.” He frowned. “You’re not taking it out, are you? Looks kind of gloomy out.” I made a smile. “Just want to make sure it’s well secured, check the ropes and all.” He was back with the game. He winced at some error made by his preferred team. “Uh-huh. Okay.” I stepped back, turned, and walked down the hall. The door to Marco’s room was ajar. I paused to look inside. I almost couldn’t do otherwise because the other voice in my head, the beaten-down, repressed human voice, was alive and screaming and screaming at me, begging me, pleading <No! No! No!> Marco was still asleep. -
Articles Causal Inference in Civil Rights Litigation
VOLUME 122 DECEMBER 2008 NUMBER 2 © 2008 by The Harvard Law Review Association ARTICLES CAUSAL INFERENCE IN CIVIL RIGHTS LITIGATION D. James Greiner TABLE OF CONTENTS I. REGRESSION’S DIFFICULTIES AND THE ABSENCE OF A CAUSAL INFERENCE FRAMEWORK ...................................................540 A. What Is Regression? .........................................................................................................540 B. Problems with Regression: Bias, Ill-Posed Questions, and Specification Issues .....543 1. Bias of the Analyst......................................................................................................544 2. Ill-Posed Questions......................................................................................................544 3. Nature of the Model ...................................................................................................545 4. One Regression, or Two?............................................................................................555 C. The Fundamental Problem: Absence of a Causal Framework ....................................556 II. POTENTIAL OUTCOMES: DEFINING CAUSAL EFFECTS AND BEYOND .................557 A. Primitive Concepts: Treatment, Units, and the Fundamental Problem.....................558 B. Additional Units and the Non-Interference Assumption.............................................560 C. Donating Values: Filling in the Missing Counterfactuals ...........................................562 D. Randomization: Balance in Background Variables ......................................................563 -
Synthetic Control Method: Inference, Sensitivity Analysis and Confidence Sets∗
Synthetic Control Method: Inference, Sensitivity Analysis and Confidence Sets∗ Sergio Firpo† Vitor Possebom‡ Insper Yale University September 1st, 2017 Abstract We extend the inference procedure for the synthetic control method in two ways. First, we impose a parametric form to the treatment assignment probabilities that includes, as a particular case, the uniform distribution that is assumed by Abadie et al.(2015). By changing the value of this parameter, we can analyze the sensitiveness of the test's decision to deviations from the usual uniform distribution assumption. Second, we modify the RMSPE statistic to test any sharp null hypothesis, including, as a specific case, the null hypothesis of no effect whatsoever analyzed by Abadie et al.(2015). Based on this last extension, we invert the test statistic to estimate confidence sets that quickly show the point-estimates' precision, and the test's significance and robustness. We also extend these two tools to other test statistics and to problems with multiple outcome variables or multiple treated units. Furthermore, in a Monte Carlo experiment, we find that the RMSPE statistic has good properties with respect to size, power and robustness. Finally, we illustrate the usefulness of our proposed tools by reanalyzing the economic impact of ETA's terrorism in the Basque Country, studied first by Abadie & Gardeazabal(2003) and Abadie et al.(2011). Keywords: Synthetic Control Estimator, Hypothesis Testing, Sensitivity Analysis, Con- fidence Sets JEL Codes: C21, C23, C33 ∗We are grateful to FAPESP that provided financial aid through grant number 2014/23731-3. We are in debt to the editor and two anonymous referees for useful suggestions. -
Causation and Causal Inference in Epidemiology
PUBLIC HEALTH MAnERS Causation and Causal Inference in Epidemiology Kenneth J. Rothman. DrPH. Sander Greenland. MA, MS, DrPH. C Stat fixed. In other words, a cause of a disease Concepts of cause and causal inference are largely self-taught from early learn- ing experiences. A model of causation that describes causes in terms of suffi- event is an event, condition, or characteristic cient causes and their component causes illuminates important principles such that preceded the disease event and without as multicausality, the dependence of the strength of component causes on the which the disease event either would not prevalence of complementary component causes, and interaction between com- have occun-ed at all or would not have oc- ponent causes. curred until some later time. Under this defi- Philosophers agree that causal propositions cannot be proved, and find flaws or nition it may be that no specific event, condi- practical limitations in all philosophies of causal inference. Hence, the role of logic, tion, or characteristic is sufiicient by itself to belief, and observation in evaluating causal propositions is not settled. Causal produce disease. This is not a definition, then, inference in epidemiology is better viewed as an exercise in measurement of an of a complete causal mechanism, but only a effect rather than as a criterion-guided process for deciding whether an effect is pres- component of it. A "sufficient cause," which ent or not. (4m JPub//cHea/f/i. 2005;95:S144-S150. doi:10.2105/AJPH.2004.059204) means a complete causal mechanism, can be defined as a set of minimal conditions and What do we mean by causation? Even among eral. -
Experiments & Observational Studies: Causal Inference in Statistics
Experiments & Observational Studies: Causal Inference in Statistics Paul R. Rosenbaum Department of Statistics University of Pennsylvania Philadelphia, PA 19104-6340 1 My Concept of a ‘Tutorial’ In the computer era, we often receive compressed • files, .zip. Minimize redundancy, minimize storage, at the expense of intelligibility. Sometimes scientific journals seemed to have been • compressed. Tutorial goal is: ‘uncompress’. Make it possible to • read a current article or use current software without going back to dozens of earlier articles. 2 A Causal Question At age 45, Ms. Smith is diagnosed with stage II • breast cancer. Her oncologist discusses with her two possible treat- • ments: (i) lumpectomy alone, or (ii) lumpectomy plus irradiation. They decide on (ii). Ten years later, Ms. Smith is alive and the tumor • has not recurred. Her surgeon, Steve, and her radiologist, Rachael de- • bate. Rachael says: “The irradiation prevented the recur- • rence – without it, the tumor would have recurred.” Steve says: “You can’t know that. It’s a fantasy – • you’re making it up. We’ll never know.” 3 Many Causal Questions Steve and Rachael have this debate all the time. • About Ms. Jones, who had lumpectomy alone. About Ms. Davis, whose tumor recurred after a year. Whenever a patient treated with irradiation remains • disease free, Rachael says: “It was the irradiation.” Steve says: “You can’t know that. It’s a fantasy. We’ll never know.” Rachael says: “Let’s keep score, add ’em up.” Steve • says: “You don’t know what would have happened to Ms. Smith, or Ms. Jones, or Ms Davis – you just made it all up, it’s all fantasy. -
Randomized Controlled Trials, Development Economics and Policy Making in Developing Countries
Randomized Controlled Trials, Development Economics and Policy Making in Developing Countries Esther Duflo Department of Economics, MIT Co-Director J-PAL [Joint work with Abhijit Banerjee and Michael Kremer] Randomized controlled trials have greatly expanded in the last two decades • Randomized controlled Trials were progressively accepted as a tool for policy evaluation in the US through many battles from the 1970s to the 1990s. • In development, the rapid growth starts after the mid 1990s – Kremer et al, studies on Kenya (1994) – PROGRESA experiment (1997) • Since 2000, the growth have been very rapid. J-PAL | THE ROLE OF RANDOMIZED EVALUATIONS IN INFORMING POLICY 2 Cameron et al (2016): RCT in development Figure 1: Number of Published RCTs 300 250 200 150 100 50 0 1975 1980 1985 1990 1995 2000 2005 2010 2015 Publication Year J-PAL | THE ROLE OF RANDOMIZED EVALUATIONS IN INFORMING POLICY 3 BREAD Affiliates doing RCT Figure 4. Fraction of BREAD Affiliates & Fellows with 1 or more RCTs 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 1980 or earlier 1981-1990 1991-2000 2001-2005 2006-today * Total Number of Fellows and Affiliates is 166. PhD Year J-PAL | THE ROLE OF RANDOMIZED EVALUATIONS IN INFORMING POLICY 4 Top Journals J-PAL | THE ROLE OF RANDOMIZED EVALUATIONS IN INFORMING POLICY 5 Many sectors, many countries J-PAL | THE ROLE OF RANDOMIZED EVALUATIONS IN INFORMING POLICY 6 Why have RCT had so much impact? • Focus on identification of causal effects (across the board) • Assessing External Validity • Observing Unobservables • Data collection • Iterative Experimentation • Unpack impacts J-PAL | THE ROLE OF RANDOMIZED EVALUATIONS IN INFORMING POLICY 7 Focus on Identification… across the board! • The key advantage of RCT was perceived to be a clear identification advantage • With RCT, since those who received a treatment are randomly selected in a relevant sample, any difference between treatment and control must be due to the treatment • Most criticisms of experiment also focus on limits to identification (imperfect randomization, attrition, etc. -
Reflections on Experimental Techniques in the Law*
University of Chicago Law School Chicago Unbound Journal Articles Faculty Scholarship 1974 Reflections on Experimental echniquesT in the Law Hans Zeisel Follow this and additional works at: https://chicagounbound.uchicago.edu/journal_articles Part of the Law Commons Recommended Citation Hans Zeisel, "Reflections on Experimental echniquesT in the Law," 15 Jurimetrics Journal 256 (1974). This Article is brought to you for free and open access by the Faculty Scholarship at Chicago Unbound. It has been accepted for inclusion in Journal Articles by an authorized administrator of Chicago Unbound. For more information, please contact [email protected]. REFLECTIONS ON EXPERIMENTAL TECHNIQUES IN THE LAW* Hans Zeiselt Much of the law's reasoning turns on the effects of the rules it creates or enforces. Normally these effects are alleged or implied, but rarely proven. Yet during the last decades, first the natural sciences and, learn- ing from them, the social sciences have developed techniques of ek- perimentation that would allow firmer determinations of what a rule of law does or does not accomplish.' The basic tool (and also the paradigm for retrospective analysis) is the controlled experiment. Its essence is simple: The objects or people on which the experiment is to be performed are divided randomly, that is, by some lottery device, into two groups; the experimental treatment is then applied to the one group and withheld from the other, the control group. If an effect is found in the experimental group that is absent from the control group, it can be attributed to the experimental treatment, since at the time of the prior random selection the two groups had been strictly comparable, and in fact interchangeable.' And randomization assures that whatever the outcome of the experiment, it is possible to calculate the degree of certainty that can be attached to it.