PRE - FEASIBILITY REPORT

For

PROPOSED BULK DRUGS MANUFACTURING UNIT

at

Sy. No. 138/3, APIIC - Industrial Park, Gollapuram Village, Hindupur Mandal, Anantapur District, Andhra Pradesh State

by

SRIPHAL LIFE SCIENCES PVT. LTD.

Reg Office: D.No. 21-8-243, Teachers Colony, Hindupur, Anantapur Dist., Andhra Pradesh state.

November, 2019

Contents

S. No. Description Page no. 1.0 Executive Summary 1 2.0 Introduction of the Project 2 2.1 Brief description of nature of the project 2 2.2 Brief description of project proponent 2 Need for the project and its importance to the country 2.3 2-4 and or region 2.4 Demand-Supply Gap 4 Employment Generation (Direct and Indirect) due to the 2.5 4 project 3.0 Project description 5 3.1 Proposed Products and Production Capacity 9 -10 3.2 Manufacturing Process 10 3.3 Resource – Utilize and Recycling 11 3.3.1 Water Requirement 11-12 3.3.2 Power Requirement 12 3.3.3 Fuel Requirement 12 3.4 Quantity of wastes to be generated 12 3.4.1 Waste Water Generation and utilization 12 Hazardous and Solid waste generation and Disposal 3.4.2 13 method 3.5 Applicability of the SO 1533 (E) 13-14 4.0 Site Analysis 14 4.1 Connectivity 14 4.2 Land Form, Land use and Land ownership 14 4.3 Existing Infrastructure 14 4.4 Soil classification 14 4.5 Climatic data from secondary sources 14 4.6 Social Infrastructure available. 15 5.0 Planning brief 15 6.0 Proposed infrastructure 15 6.1 Industrial Area 15 6.2 Residential Area 15 6.3 Green Belt 15 6.4 Social Infrastructure 15 6.5 Water management 16 6.6 Sewerage System 16 6.7 Industrial Waste Management 16 7.0 Rehabilitation and Resettlement (R&R) Plan 16 8.0 Project Schedule and Cost estimates 16 9.0 Analysis of project 16

LIST OF TABLES

Table No Description Page no. Details of Employment Generation for the Proposed 2.1 4 Project 3.1 List of Proposed Products and its Quantities 9 -10 3.2 List of By- Products and its Quantities 10 3.3 Water Requirement Details 11 3.4 Effluent generation Details 12 3.5 Effluent generation details and Treatment Method 12-13 3.6 Hazardous & Solid waste generation details and 14 Disposal Method

LIST OF FIGURES

Figure No Description Page no. 3.1 Location Map 6 3.2 Google Earth Map showing Sriphal Life Sciences Pvt. 7 Ltd 3.3 Topo Map showing Sriphal Life Sciences Pvt. Ltd 8

LIST OF FLOW CHART

Flow Description Page no. Chart No 3.1 Generalized Flow Chart for Bulk Drug Manufacturing 11

Pre Feasibility Report

1.0 EXECUTIVE SUMMARY Sriphal Life Sciences Pvt. Ltd. is proposed for Manufacturing of Bulk Drugs at Sy.No.: 138/3, APIIC - Industrial Park, Gollapuram (V), Hindupur Mandal, Anantapur District, Andhra Pradesh state.

S. No Parameter Description Sriphal Life Sciences Pvt. Ltd. Sy.No.: 138/3, APIIC - Industrial Park, Gollapuram 1 Project Location (V), Hindupur Mandal, Anantapur District, Andhra Pradesh state Category of Project as 5(f), Synthetic Organic Chemical Industry 2 per EIA Notification & Category - “A” Amendments 3 Project cost 800 Lakhs (8 Crores) 4 Plot area 2.37 Acres (9584.83 Sq. m) 5 Proposed Products Mentioned in Table 3.1 (I)Electricity 6 600 KVA Requirement Andhra Pradesh Southern Power Distribution Source of electricity Company Limited (APSPDCL) D. G. Set 250 KVA & 320 KVA

7 (II)Water consumption 112.62 KLD Andhra Pradesh Industrial Infrastructure Source of water Corporation (APIIC) water supply Waste water generation 32.72 KLD

8 (III) Boiler 2.0 TPH & 3.0 TPH Coal fired Boilers 9 (IV) Fuel Coal – 17 MT/Day 10 Mode of disposal Mentioned in Table 3.6 of report 11 Solid waste generation Mentioned in Table 3.6 of report Andhra Pradesh – Karnataka State Boundary is 12 Interstate Boundary 1.10 km (NE) from project site. 13 Nearest Highway SH-472 – 2.15 Km (W) Lake near Gollapuram – 1.00 Km (SE) Lake near Manepalli – 5.10 Km (NE) Penner River – 3.60 Km (W) Lake near Santebidanuru – 4.40 Km (W) 14 Nearest Water bodies Lake near Kadagatturu – 7.05 Km (W) Kumadvati River – 8.75 Km (W) Lake near Kotipi – 2.70 Km (NNE) Lake near Appalakunta – 3.40 Km (SW) Lake near Kirikera – 4.55 Km (NW)

Sriphal Life Sciences Pvt. Ltd. Page 1 Pre Feasibility Report

S. No Parameter Description Lake near Bevinahalli – 5.90 Km (NW) Lake near Pulamati – 5.35 Km (N) Lake near Kodihalli – 8.20 Km (NE) 15 Nearest Reserved Forest None within 10 Km radius 16 Major habitation Hindupur – 8.70 Km (N) 17 Nearest habitation Gollapuram village – 0.72 Km (SE)

2.0 INTRODUCTION OF THE PROJECT The objective of this pre- feasibility study is to provide information for the proposed Bulk Drugs Manufacturing unit of Sriphal Life Sciences Pvt. Ltd. located at Sy.No.: 138/3, APIIC - Industrial Park, Gollapuram (V), Hindupur Mandal, Anantapur District, Andhra Pradesh state.

2.1 Brief description of nature of the project Sriphal Life Sciences Pvt. Ltd. is proposing for Bulk Drugs manufacturing unit. We will start manufacturing of Bulk Drugs - 70 MT/Month after getting the EC from MoEF&CC, New Delhi.

2.2 Brief description of project proponent M.V. Satyanarayana Murthy, K. Anand Nazmal and K Sreenivasa Rao are Directors of the company. NS Bhaskar Rao is the Additional Director of the company.

2.3 Need for the project and its importance to the country and region Sriphal Life Sciences Pvt. Ltd. is intended to start a manufacturing unit of Bulk Drugs at Sy.No.: 138/3, APIIC - Industrial Park, Gollapuram (V), Hindupur Mandal, Anantapur District, Andhra Pradesh state.  Availability of the well-connected road for easy transportation of the construction equipments and materials, Raw materials and finished products.  Easy availability of skilled and unskilled labor for construction of Plant. Bulk Drugs are hygienically formulated using high grade raw materials and they are used in the pharmaceutical and cosmetic industry. The global Bulk drug market is expected to grow at a high rate owing to rising research and development activity globally.

Sriphal Life Sciences Pvt. Ltd. Page 2 Pre Feasibility Report

API intermediate: API or active pharmaceutical ingredient intermediates are the raw materials or raw drugs responsible for therapeutic action. They are the active ingredients which are later converted into various forms such as tablets, capsules, suspensions etc. API acts as a drug itself.

On the basis of end user, the global Bulk drug market is segmented into Pharmaceutical industry, Biotechnology industry, and Chemical industry.

2.4 Demand-Supply Gap There is a quite considerable gap between supply and demand for fine chemicals, bulk drugs. Very few players are in the market who can offer continuous supply. The company wants to bridge this gap between demand and supply by the production capacity and thereby, making good business. Company's marketing edge comes from its direct and close contact with the customers. Their products are major strength of their customers. Each stage of their product is been monitored /checked for their quality to ensure quality product reaches their customer.

2.5 Employment Generation (Direct and Indirect) due to the project Approximate employment generation due to proposed unit is 50. Apart from this there will be significant non estimated employment generation at the supplier firms and service industry providing services to the company. Company shall be giving preference to people from economically weaker sections for employment in various semi-skilled/unskilled jobs thereby contributing to their upliftment.

TABLE 2.1: DETAILS OF EMPLOYMENT GENERATION FOR THE PROPOSED PROJECT S. No. Manpower Total No. 1 Un-Skilled 25 2 Skilled 20 3 Managerial & Supervisory 5

3.0 Project Description Sriphal Life Sciences Pvt. Ltd. is proposing to manufacture Bulk Drugs with the production capacity of 70 TPM.

The Location map is shown at Figure - 3.1, Google earth map showing Sriphal Life

Sriphal Life Sciences Pvt. Ltd. Page 3 Pre Feasibility Report

Sciences Pvt. Ltd. plant is shown at Figure - 3.2 and Topo map showing Sriphal Life Sciences Pvt. Ltd. in Figure – 3.3 The site central coordinates are

Latitude: 13° 44' 01.66" N Longitude: 77° 31' 07.39" E

The project site does not offer any negative impact on the local area, but rather has a positive impact on socio-economic conditions of the habitants around it because of employment to local people. The Sriphal Life Sciences Pvt. Ltd. is 2.15 Km distance away from SH-472 at West direction.

Sriphal Life Sciences Pvt. Ltd. Page 4 Pre Feasibility Report

FIGURE 3.1: LOCATION MAP

Sriphal Life Sciences Pvt. Ltd.

Sriphal Life Sciences Pvt. Ltd. Page 6 Pre Feasibility Report

FIGURE 3.2: GOOGLE EARTH MAP SHOWING SRIPHAL LIFE SCIENCES PVT. LTD.

Sriphal Life ciences Pvt. Ltd. Page 7 Pre Feasibility Report

FIGURE 3.3: TOPO MAP SHOWING SRIPHAL LIFE SCIENCES PVT. LTD.

Sriphal Life Sciences Pvt. Ltd. Page 8 PRE-FEASIBILITY REPORT

3.1 Proposed Products and Production Capacity Sriphal Life Sciences Pvt. Ltd. Propose to produce below mention products with Manufacturing Capacity of 70 TPM and the list of products are shown in Table 3.1.

TABLE 3.1: LIST OF PROPOSED PRODUCTS AND QUANTITIES Production S.No Product Name Capacity in MT/Month 1 Amlodipine Besylate 3.00 2 Atorvastatin calcium 4.00 3 Cetirizine dihydrochloride 10.00 4 Curcumin 30.00 5 Esomeprazole Magnesium Trihydrate 10.00 6 Fexofenadine hydrochloride 10.00 7 Fluconazole 5.00 8 Montelukast sodium 1.00 9 Pantoprazole sodium 5.00 10 Piroctone olamine 10.00 11 Rosuvastatin calcium 5.00 12 Sertraline Hydrochloride 5.00 Total (Any five products will be 70.00 manufactured at any point of time)

TABLE 3.2: LIST OF BY-PRODUCTS AND ITS QUANTITIES Quantity S. No Name of the Product Name of the By-Product in Kg/Day 1 Atorvastatin calcium Potassium chloride 57.38 Boric acid 25.87 Fexofenadine Sodium methoxide 22.61 2 hydrochloride Potassium iodide 127.93 Potassium chloride 96.58 3 Pantoprazole Sodium Sodium Di hydrogen phosphate 483.42 Ammonium Chloride 35.17 4 Sertraline hydrochloride Boric acid 11.82

Note: The quantities of By-products are generated based on respective products being manufactured.

3.2 Manufacturing Process The manufacturing process of Bulk drugs consists of chemical synthesis extending to stages of processing involving different type of chemical reactions. The

Sriphal Life Sciences Pvt. Ltd. Page 9 PRE-FEASIBILITY REPORT generalized Flow chart for bulk drug manufacturing is shown in Flow chart 3.1.

FLOW CHART 3.1: GENERALIZED FLOW CHART FOR BULK DRUG MANUFACTURING

3.3 Resource – Utilize & Recycling 3.3.1 Water Requirement Water requirement of the project for domestic and industrial activity during operation phase will be 112.62 KLD. The water requirement will be met through APIIC water supply. The details of water requirement are shown in below Table 3.3.

TABLE 3.3: WATER REQUIREMENT DETAILS

Water S. No Purpose Input in KLD 1 Process 12.12 2 Washings 2.00 3 Boiler make up 30.00 4 Cooling towers make up 56.00 5 Scrubbing system 4.00 6 Domestic 2.50 7 Gardening 6.00 Total 112.62

Sriphal Life Sciences Pvt. Ltd. Page 10 PRE-FEASIBILITY REPORT

112.62 KLD of water will be met from Andhra Pradesh Industrial Infrastructural Corporation (APIIC) water supply.

3.3.2 Power Requirement Power requirement of proposed project will be made available through APSPDCL. The total power requirement for the unit is 600 KVA respectively. The unit will have 250 KVA & 320 KVA D. G. sets to meet the emergency power requirement of the plant.

3.3.3 Fuel Requirement The industry proposed to install 3.0 TPH & 2.0 TPH Coal Fired Boilers. Total Coal requirement will be 17 TPD, it will be procured from local sources.

3.4 Quantity of wastes to be generated 3.4.1 Waste Water Generation and utilization Total effluent generated in the project is 32.72 KLD. Generated waste water will be sent to ZLD system. The total effluent generated from the proposed project is given in Table 3.4 and treatment method is given in Table 3.5.

TABLE 3.4: EFFLUENT GENERATION DETAILS Effluent S. No Purpose in KLD 1 Process 13.72 2 Washings 2.00 3 Boiler Blow down 5.00 4 Cooling towers Bleed off 6.00 5 Scrubbing system 4.00 6 Domestic 2.00 Total 32.72

TABLE 3.5: EFFLUENT GENERATION DETAILS AND TREATMENT METHOD Effluent HTDS LTDS Unit Generation Treatment Method KLD KLD in KLD Process 12.90 0.82 13.72 HTDS: HTDS effluents sent to MEE Washings 0.00 2.00 2.00 system followed by BTP. LTDS: Boiler Blow down 0.00 5.00 5.00 LTDS effluents treated in BTP – RO Plant. Cooling towers Bleed off 0.00 6.00 6.00 RO Rejects to MEE System

Sriphal Life Sciences Pvt. Ltd. Page 11 PRE-FEASIBILITY REPORT

Scrubbing system 4.00 0.00 4.00 and RO permeate to reuse, Condensate from MEE to reuse Domestic 0.00 2.00 2.00 and MEE residue to ATFD. Total 16.9 15.82 32.72

3.4.2 Hazardous & Solid waste generation and Disposal Method The Hazardous and Solid wastes generated from the proposed project and its method of disposal are given in Table 3.6.

TABLE 3.6: HAZARDOUS & SOLID WASTE GENERATION DETAILS AND DISPOSAL METHOD

Name of the S. No Quantity Disposal Method Hazardous Waste Organic solid waste 1 2118 Kg/Day (Process Residue) Will be sent to Cement 2 Spent Carbon 41 Kg/Day Industries 3 Solvent Distillation Residue 302 Kg/Day 4 Inorganic Solid Waste 431 Kg/Day 5 ETP Sludge 20 Kg/Day Will be sent to TSDF 1448.50 6 MEE Salts Kg/Day Organic distillate from MEE Will be sent to Cement 7 440 Kg/Day Stripper Industries Will be set to SPCB 100 8 Used Oils Authorized Agencies for Ltrs/Annum Reprocessing/ Recycling Detoxified Containers/ 400 After Detoxification sent to 9 Container liners No’s / Month authorized agencies. Send back to suppliers for Used Lead Acid Batteries 4 No’s/ Annum 10 buyback of New Batteries Solid waste details Will be sent to Brick 11 Ash from boiler 5950 Kg/Day Manufacturers

3.5 Applicability of the SO 1533 (E) The applicability of the S. O. 1533 for the proposed project in the Industrial Park was explored by considering different possibilities & provision made in the said notification. Considering the project location it is noticed that the proposed project is located in Industrial Park and interstate boundary is within 5km radius, thus falls under Category 5 (f) “A” of the Schedule-I of EIA Notification SO 1533 as it is applicability of general conditions. As per the provision of the SO 1533, it is necessary to get Environmental Clearance by applying to MoEF&CC, New Delhi along with the Environmental Impacts Assessment Study Report for the proposed project prior to commissioning of the

Sriphal Life Sciences Pvt. Ltd. Page 12 PRE-FEASIBILITY REPORT project activities. 4.0 Site Analysis 4.1 Connectivity Sriphal Life Sciences Pvt. Ltd. located at Sy.No. 138/3, APIIC - Industrial Park, Gollapuram (V), Hindupur Mandal, Anantapur District, Andhra Pradesh state.

 The nearest habitation from the site is Gollapuram village at a distance of 0.72 Km towards SE direction.  Nearest railway station is Devarapalle Railway Station – 1.20 Km (SW)  The nearest airport is Kempegowda International Airport - 61 Km (SSE)  The Nearest Highway is SH – 472 – 2.15 Km (W)

4.2 Land form, Land use and Land ownership The proposed project is within the APIIC industrial area. The land use of the project is 2.37 acres (9584.83 Sq. m).

4.3 Existing Infrastructure The Proposed project is located in the Industrial Park – Hindupur. The common infrastructure provided by APIIC will be used for the proposed project.

4.4 Soil classification The district is mainly covered by three types of soils such as Red Sandy soil, Lateritic soil & Mixed red soil.

4.5 Climatic data from secondary source Annual Max Temp is 44.1 0C Annual Min Temp is 9.4 0C Normal Annual Rainfall is 577.2 mm (Source: IMD Climatatological Normals Anantapur, 1981 - 2010)

4.6 Social Infrastructure available Well developed social infrastructure facilities are available at nearby habitations.

5.0 Planning Brief Propose to manufacture Bulk Drugs. Further the project activities will abide all the rules and regulations of statutory authorities.

Sriphal Life Sciences Pvt. Ltd. Page 13 PRE-FEASIBILITY REPORT

6.0 Proposed Infrastructure 6.1 Industrial Area Any further infrastructure and other facilities will be developed after getting the statutory clearance from the MoEF&CC, New Delhi.

6.2 Residential Area The employees who will work in the industry will be from nearby villages and hence there is no proposal for residential area for employees.

6.3 Green Belt Approximately 40.51 % of Green Belt will develop and it will be maintained.

6.4 Social Infrastructure Facilities like road, railway and communication are good; Banks, ATM's and medical facilities are also adequate. Amenities: Education- schools including middle, secondary and higher secondary schools, social welfare hostels.

Medical and Health- Community Health Centre & Primary Health Centre are available in Hindupur which is 8.70 Km at North direction from proposed project site. Power and water- All the villages are electrified and drinking water facilities are extended to all villages. Rail and Road- The project site is very well connected by road through National Highway SH – 472.

6.5 Water management Water requirement will be met through APIIC water supply.

6.6 Sewerage System Domestic effluent will be sent to ZLD system.

6.7 Industrial Wastewater Management Due to proposed project, the effluent from process, washings, boiler blow down, cooling tower bleed off and scrubbers will be sent to ZLD system.

7.0 Rehabilitation and Resettlement (R & R) Plan Rehabilitation & Resettlement (R&R) plan is not applicable to this proposed project.

Sriphal Life Sciences Pvt. Ltd. Page 14 PRE-FEASIBILITY REPORT

8.0 Project Schedule & Cost Estimates Proposed project activities will be started after getting Environmental Clearance from MoEF&CC, New Delhi for manufacturing the Bulk drugs.

The project cost is 800 Lakhs (8.0 Crores) will be used for Civil works, Plant & machinery and misc.

9.0 Analysis of proposal (Final Recommendations)  Local people will get direct financial benefit by way of employment.  Local people will get some contracts of supply and services to get indirect income.  More revenue will be generated by the way of GST to the State & Central exchequers.

Sriphal Life Sciences Pvt. Ltd. Page 15