A Randomised Controlled Trial
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Listening to music prior to bronchoscopy reduces anxiety – a randomised controlled trial Jeppesen, Elisabeth; Pedersen, Carsten M.; Larsen, Klaus R.; Walsted, Emil S.; Rehl, Anne; Ehrenreich, Julie; Schnoor, Sascha; Backer, Vibeke Published in: European Clinical Respiratory Journal DOI: 10.1080/20018525.2019.1583517 Publication date: 2019 Document version Publisher's PDF, also known as Version of record Document license: CC BY-NC Citation for published version (APA): Jeppesen, E., Pedersen, C. M., Larsen, K. R., Walsted, E. S., Rehl, A., Ehrenreich, J., Schnoor, S., & Backer, V. (2019). Listening to music prior to bronchoscopy reduces anxiety – a randomised controlled trial. European Clinical Respiratory Journal, 6(1), 1-10. [1583517]. https://doi.org/10.1080/20018525.2019.1583517 Download date: 01. Oct. 2021 European Clinical Respiratory Journal ISSN: (Print) 2001-8525 (Online) Journal homepage: https://www.tandfonline.com/loi/zecr20 Listening to music prior to bronchoscopy reduces anxiety – a randomised controlled trial Elisabeth Jeppesen, Carsten M. Pedersen, Klaus R. Larsen, Emil S. Walsted, Anne Rehl, Julie Ehrenreich, Sascha Schnoor & Vibeke Backer To cite this article: Elisabeth Jeppesen, Carsten M. Pedersen, Klaus R. Larsen, Emil S. Walsted, Anne Rehl, Julie Ehrenreich, Sascha Schnoor & Vibeke Backer (2019) Listening to music prior to bronchoscopy reduces anxiety – a randomised controlled trial, European Clinical Respiratory Journal, 6:1, 1583517, DOI: 10.1080/20018525.2019.1583517 To link to this article: https://doi.org/10.1080/20018525.2019.1583517 © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Published online: 17 Mar 2019. Submit your article to this journal Article views: 403 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=zecr20 EUROPEAN CLINICAL RESPIRATORY JOURNAL 2019, VOL. 6, 1583517 https://doi.org/10.1080/20018525.2019.1583517 Listening to music prior to bronchoscopy reduces anxiety – a randomised controlled trial Elisabeth Jeppesena, Carsten M. Pedersenb, Klaus R. Larsena, Emil S. Walsted c, Anne Rehla, Julie Ehrenreicha, Sascha Schnoora and Vibeke Backer a,c aDepartment of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark; bDepartment of Cardiothoracic Anaesthesiology, Rigshospitalet, Copenhagen, Denmark; cRespiratory Research Unit, Bispebjerg Hospital, Copenhagen, Denmark ABSTRACT ARTICLE HISTORY Background: Listening to music as a means of relieving anxiety before and during endoscopy has Received 16 December 2018 been examined in several studies but results so far are contradictory and inconclusive. Accepted 7 February 2019 Aims: We aimed to determine whether listening to music could reduce anxiety prior to and KEYWORDS during bronchoscopy, and whether it is influenced by the patient’s preference in music. Bronchoscopy; lung cancer; Methods: 300 patients undergoing bronchoscopy for suspected lung cancer were randomly anxiety; music; self-selected assigned to: self-selected music, specially-designed music (MusiCureTM), or control (no sound). music; MusiCure Spielberger’s State-Trait Anxiety Inventory (STAI) was administered three times: at admission, after 20 min with or without music (preceding bronchoscopy), and shortly before discharge. The primary outcome was STAI state score after 20 min, with or without exposure to music prior to bronchoscopy. Results: On average, music reduced the STAI score by 2.5 points (95% CI, 1.1 to 4.0; p < 0.001) compared with the control group. This reduction was largest in the self-selected music group (3.4; 95% CI, 1.5 to 5.3; p < 0.001). In contrast, specially designed music did not significantly reduce STAI score (1.7; 95% CI, −0.3 to 3.6; p = 0.1). Conclusion: Listening to music reduces anxiety in patients undergoing bronchoscopy, provided that the music complies with the patient’s preferences. Introduction Colt et al. Patients were exposed to pre-recorded piano improvisations versus no music during bronchoscopy, Bronchoscopy is an important invasive tool in the diag- and STAI was used as primary outcome. It was con- nosis of lung cancer. Fear and anxiety related to broncho- cluded that there was no significant effect of music on scopy are quite common in patients, much like emotions anxiety [8]. observed in patients facing other invasive procedures A major limitation in both studies is the use of [1–3]. Since anxiety is an unpleasant sensation, which investigator-selected music. While some evidence exists negatively affects patients’ tolerance of the procedure, it that music influences anxiety, further research is is important that healthcare staff address and seek to needed to establish the effect of patient-selected music relieve anxiety [2]. With administration of sedatives in relation to investigator-selected music [9,10]. comes an increased risk of respiratory depression [4–6]. The aim of this study was to investigate the anxiety- In a previous randomised investigator-blinded study, reducing effect of self-selected and investigator-selected we examined the effect of specially designed music music, played for a period of 20 min prior to bronchoscopy. (MusiCureTM), played for 10 min before bronchoscopy and throughout the procedure. Anxiety was measured by Spielberger’s State-Trait Anxiety Inventory (STAI) on Material and methods arrival, after 10 min with or without music, and at dis- Subjects charge. We found no significant effect of music when adjusting for baseline anxiety and sex [7]. The study was approved by the Danish Ethics Anxiety and music in relation to bronchoscopy have Committee (Protocol no. H-3–2014-065), and patients also been studied in a randomised controlled trial by were consecutively included in the study among CONTACT Elisabeth Jeppesen [email protected] Department of Respiratory Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark Take home message: Listening to music prior to bronchoscopy reduces anxiety if it complies with patients’ preferences. © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 2 E. JEPPESEN ET AL. patients referred for examination for pulmonary to randomisation and the 300 patients included in the nodules in the period between October 2016 and study. The excluded patients were older, had lower November 2017. In total, 1162 patients were assessed weight and height and lower levels of lung function. for eligibility, 671 patients were excluded, due to exclu- There was, however, no significant difference regarding sion criteria, and a further 191 eligible patients refused gender. to participate, leaving 300 patients to be included in the study and randomised to three groups (Figure 1). Study design Baseline characteristics were not significantly different between the three groups (Table 1), and no clinically Randomisation was performed by block randomisation significant differences were observed between those in blocks of 15 patients, using Statistical Package for 266 who were analysed per protocol, and those 34 the Social Sciences (SPSS) version 22.0. Patients were who were not. There is no difference in conclusions assigned to one of three treatment groups: when analysing data as intention-to-treat and per- protocol analysis. (1) self-selected genre of music (Table 2) However, there were significant differences in some (2) specially-designed music (MusiCure™) baseline values between those who were excluded prior (3) control (no sound) Flowchart of the trial Assessed for eligibility (n = 1162) Excluded (n = 862) -hearing impairment n=181 nemllornE -memory impairment n=66 -does not understand Danish n=93 -not able to operate an Ipad n=67 -other sedation than midazolam/fentanyl n=4 -other invasive examination planned alongside bronchoscopy n=146 -earlier history of bronchoscopy n=108 -refused to participate n = 191 -other reasons n = 6 Randomized (n = 300) Allocated to control Allocated to MusiCure Allocated to self- group (n =100) selected music (n = 100) (n =100) Received allocated no i intervention (n =100) t Received allocated Received allocated a co intervention (n = 100) intervention (n =100) l l Did not receive allocated At Did not receive allocated intervention (n = 0) Did not receive allocated intervention (n = 0) intervention (n = 0) Lost to follow-up Lost to follow-up Lost to follow-up puwolloF (n = 9) (n = 13) (n = 4) Discontinued intervention Discontinued intervention Discontinued intervention (n = 2) (2 patients withdrew (n = 5) (2 patients withdrew (n = 1) (patient withdrew consent) consent and 3 got their consent) bronchoscopy cancelled) sis Analysed (n = 99) Analysed (n = 100) Analysed (n = 100) y lanA Excluded from analysis Excluded from analysis Excluded from analysis (n =1) because of no values (n = 0) (n = 0) Figure 1. Flowchart of the trial (CONSORT flow diagram, www.consort-statement.org). EUROPEAN CLINICAL RESPIRATORY JOURNAL 3 Table 1. Baseline characteristics. All (n = 300) Controls (n = 100) MusiCure (n = 100) Self-selected (n = 100) p Female/male 154/146 48/52 51/49 55/45 0.6 Age in years 61 (12) 61 (14) 61(12) 61 (12)