H OH metabolites OH Article Caucasian Gentiana Species: Untargeted LC-MS Metabolic Profiling, Antioxidant and Digestive Enzyme Inhibiting Activity of Six Plants Daniil N. Olennikov 1,* , Aydan I. Gadimli 2, Javanshir I. Isaev 2, Nina I. Kashchenko 1 , Alexey S. Prokopyev 3, Tatyana N. Kataeva 3, Nadezhda K. Chirikova 4 and Cecile Vennos 5 1 Laboratory of Medical and Biological Research, Institute of General and Experimental Biology, Siberian Division, Russian Academy of Science, 6 Sakh’yanovoy Street, 670047 Ulan-Ude, Russia;
[email protected] 2 Department of Pharmacognosy, Azerbaijan Medical University, Anvar Gasimzade Street 14, Baku AZ1022, Azerbaijan;
[email protected] (A.I.G.);
[email protected] (J.I.I.) 3 Siberian Botanic Garden, Tomsk State University, Lenin Avenue 34/1, 634050 Tomsk, Russia;
[email protected] (A.S.P.);
[email protected] (T.N.K.) 4 Department of Biochemistry and Biotechnology, North-Eastern Federal University, 58 Belinsky Street, 677027 Yakutsk, Russia;
[email protected] 5 Regulatory and Medical Scientific Affairs, Padma AG, 30 Haldenstrasse, CH-8620 Wetzikon, Switzerland;
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[email protected]; Tel.: +7-9021-600-627 Received: 3 October 2019; Accepted: 5 November 2019; Published: 7 November 2019 Abstract: The members of Gentiana genus are widely distributed in the Caucasus region where they are used as phytoremedies, but they still have not been studied for their chemical composition and bioactivity. High-performance liquid chromatography with diode array and electrospray triple quadrupole mass detection (HPLC-DAD-ESI-QQQ-MS) was used to investigate metabolites of herb and roots of six gentians (Gentiana asclepiadea, G.