Supplementary Table 2B. The actual genes involved in each gene ontology term among a set of 687 inter- histological subtype-regulated genes.

GO_ID Gene ontology Gene Symbol GO:0030552 3',5'-cAMP_binding PRKAR2B GO:0030552 3',5'-cAMP_binding PRKAR2A GO:0003854 3-beta-hydroxy-delta5-steroid_dehydrogenase_activity HSD3B2 GO:0003854 3-beta-hydroxy-delta5-steroid_dehydrogenase_activity HSD3B1 GO:0008124 4-alpha-hydroxytetrahydrobiopterin_dehydratase_activity PCBD GO:0017168 5-oxoprolinase_(ATP-hydrolyzing)_activity OPLAH GO:0008413 8-oxo-7,8-dihydroguanine_triphosphatase_activity NUDT1 GO:0001612 A2B_adenosine_receptor_activity,_G-protein_coupled ADORA2B GO:0019413 acetate_biosynthesis ACAS2L GO:0006083 acetate_metabolism ACAS2L GO:0003987 acetate-CoA_ligase_activity ACAS2L GO:0006085 acetyl-CoA_biosynthesis ACAS2L GO:0006084 acetyl-CoA_metabolism ACAS2L GO:0008375 acetylglucosaminyltransferase_activity MGAT5 GO:0016881 acid-D-amino_acid_ligase_activity PAICS GO:0016881 acid-D-amino_acid_ligase_activity RNF128 GO:0016878 acid-thiol_ligase_activity SUCLA2 GO:0016878 acid-thiol_ligase_activity ACAS2L GO:0001669 acrosome ATP6V1E2 GO:0001675 acrosome_formation TBPL1 GO:0003779 actin_binding CAPZA3 GO:0003779 actin_binding MYH11 GO:0003779 actin_binding ARPC1A GO:0003779 actin_binding PLS3 GO:0003779 actin_binding CAPZB GO:0015629 actin_cytoskeleton MYH11 GO:0015629 actin_cytoskeleton CAPZA3 GO:0015629 actin_cytoskeleton ARPC1A GO:0015629 actin_cytoskeleton TNNT3 GO:0015629 actin_cytoskeleton MYOZ2 GO:0015629 actin_cytoskeleton CCT2 GO:0015629 actin_cytoskeleton CAPZB GO:0030036 actin_cytoskeleton_organization_and_biogenesis CAPZA3 GO:0030036 actin_cytoskeleton_organization_and_biogenesis ARPC1A GO:0030036 actin_cytoskeleton_organization_and_biogenesis PLS3 GO:0030036 actin_cytoskeleton_organization_and_biogenesis CAPZB GO:0030036 actin_cytoskeleton_organization_and_biogenesis ELN GO:0051017 actin_filament_bundle_formation ELN GO:0007015 actin_filament_organization ARPC1A GO:0007015 actin_filament_organization PLS3 GO:0007015 actin_filament_organization ELN GO:0030041 actin_filament_polymerization ELN GO:0030029 actin_filament-based_process CAPZA3 GO:0030029 actin_filament-based_process ARPC1A GO:0030029 actin_filament-based_process PLS3 GO:0030029 actin_filament-based_process CAPZB GO:0030029 actin_filament-based_process ELN GO:0008154 actin_polymerization_and/or_depolymerization ELN GO:0000187 activation_of_MAPK LRRN3 GO:0000187 activation_of_MAPK PRKAA1 GO:0000185 activation_of_MAPKKK MSN GO:0017106 activin_inhibitor_activity INHA GO:0006953 acute-phase_response F2 GO:0006953 acute-phase_response FN1 GO:0006953 acute-phase_response PAP GO:0004254 acylaminoacyl-peptidase_activity APEH GO:0006639 acylglycerol_metabolism GK2 GO:0006639 acylglycerol_metabolism APOB GO:0008415 acyltransferase_activity GGTLA1

1:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008415 acyltransferase_activity FEN1 GO:0004000 adenosine_deaminase_activity TENR GO:0001609 adenosine_receptor_activity,_G-protein_coupled ADORA2B GO:0030554 adenyl_nucleotide_binding PRKAA1 GO:0030554 adenyl_nucleotide_binding GK2 GO:0030554 adenyl_nucleotide_binding PRKAR2B GO:0030554 adenyl_nucleotide_binding NARS GO:0030554 adenyl_nucleotide_binding UMPK GO:0030554 adenyl_nucleotide_binding OCA2 GO:0030554 adenyl_nucleotide_binding MAPK4 GO:0030554 adenyl_nucleotide_binding WARS GO:0030554 adenyl_nucleotide_binding ITM2B GO:0030554 adenyl_nucleotide_binding CDK8 GO:0030554 adenyl_nucleotide_binding EPHA3 GO:0030554 adenyl_nucleotide_binding MAP3K5 GO:0030554 adenyl_nucleotide_binding NRBP GO:0030554 adenyl_nucleotide_binding MYH11 GO:0030554 adenyl_nucleotide_binding ATP12A GO:0030554 adenyl_nucleotide_binding SLC2A1 GO:0030554 adenyl_nucleotide_binding CDH16 GO:0030554 adenyl_nucleotide_binding TK1 GO:0030554 adenyl_nucleotide_binding DDX20 GO:0030554 adenyl_nucleotide_binding PRKAR2A GO:0030554 adenyl_nucleotide_binding DDX25 GO:0030554 adenyl_nucleotide_binding TESK2 GO:0030554 adenyl_nucleotide_binding GNE GO:0030554 adenyl_nucleotide_binding HSPA1A GO:0030554 adenyl_nucleotide_binding CCT2 GO:0030554 adenyl_nucleotide_binding DHX35 GO:0030554 adenyl_nucleotide_binding ROR1 GO:0017045 adrenocorticotropin-releasing_hormone_activity CRH GO:0016284 alanine_aminopeptidase_activity ENPEP GO:0016284 alanine_aminopeptidase_activity RNPEP GO:0008784 alanine_racemase_activity PROSC GO:0046165 alcohol_biosynthesis PRKAA1 GO:0046165 alcohol_biosynthesis PGK1 GO:0046164 alcohol_catabolism SUCLA2 GO:0046164 alcohol_catabolism LDHA GO:0046164 alcohol_catabolism PARG GO:0046164 alcohol_catabolism PGK1 GO:0006066 alcohol_metabolism SUCLA2 GO:0006066 alcohol_metabolism PRKAA1 GO:0006066 alcohol_metabolism GK2 GO:0006066 alcohol_metabolism PARG GO:0006066 alcohol_metabolism HDLBP GO:0006066 alcohol_metabolism EKI1 GO:0006066 alcohol_metabolism VLDLR GO:0006066 alcohol_metabolism LDHA GO:0006066 alcohol_metabolism IDI1 GO:0006066 alcohol_metabolism PGK1 GO:0006066 alcohol_metabolism ALDH1A3 GO:0006066 alcohol_metabolism SORL1 GO:0006066 alcohol_metabolism APOB GO:0004030 aldehyde_dehydrogenase_[NAD(P)+]_activity ALDH1A3 GO:0004028 aldehyde_dehydrogenase_activity ALDH1A3 GO:0004035 alkaline_phosphatase_activity ALPI GO:0030144 alpha-1,6-mannosyl-glycoprotein_6-beta-N-acetylglucosaminyltransferase_activity MGAT5 GO:0004557 alpha-galactosidase_activity GLA GO:0015268 alpha-type_channel_activity MID1 GO:0015268 alpha-type_channel_activity FXYD6 GO:0015268 alpha-type_channel_activity GRIN2D

2:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0015268 alpha-type_channel_activity CLIC6 GO:0015268 alpha-type_channel_activity CACNA1C GO:0015268 alpha-type_channel_activity SCN9A GO:0015837 amine/polyamine_transport SLC7A11 GO:0005275 amine/polyamine_transporter_activity SLC7A11 GO:0009309 amine_biosynthesis TMLHE GO:0009309 amine_biosynthesis BCAT1 GO:0009309 amine_biosynthesis EKI1 GO:0009309 amine_biosynthesis CBS GO:0009310 amine_catabolism INDO GO:0009308 amine_metabolism NARS GO:0009308 amine_metabolism BCAT1 GO:0009308 amine_metabolism PCBD GO:0009308 amine_metabolism CDH16 GO:0009308 amine_metabolism HS2ST1 GO:0009308 amine_metabolism EKI1 GO:0009308 amine_metabolism INDO GO:0009308 amine_metabolism TMLHE GO:0009308 amine_metabolism GNE GO:0009308 amine_metabolism WARS GO:0009308 amine_metabolism TTR GO:0009308 amine_metabolism GFPT2 GO:0009308 amine_metabolism CBS GO:0043038 amino_acid_activation NARS GO:0043038 amino_acid_activation WARS GO:0043038 amino_acid_activation CDH16 GO:0006519 amino_acid_and_derivative_metabolism CKMT2 GO:0006519 amino_acid_and_derivative_metabolism NARS GO:0006519 amino_acid_and_derivative_metabolism BCAT1 GO:0006519 amino_acid_and_derivative_metabolism GLB1 GO:0006519 amino_acid_and_derivative_metabolism PCBD GO:0006519 amino_acid_and_derivative_metabolism CDH16 GO:0006519 amino_acid_and_derivative_metabolism EKI1 GO:0006519 amino_acid_and_derivative_metabolism INDO GO:0006519 amino_acid_and_derivative_metabolism TMLHE GO:0006519 amino_acid_and_derivative_metabolism WARS GO:0006519 amino_acid_and_derivative_metabolism TTR GO:0006519 amino_acid_and_derivative_metabolism CKB GO:0006519 amino_acid_and_derivative_metabolism GFPT2 GO:0006519 amino_acid_and_derivative_metabolism CBS GO:0008652 amino_acid_biosynthesis BCAT1 GO:0008652 amino_acid_biosynthesis CBS GO:0009063 amino_acid_catabolism INDO GO:0042398 amino_acid_derivative_biosynthesis TMLHE GO:0042398 amino_acid_derivative_biosynthesis CKMT2 GO:0042398 amino_acid_derivative_biosynthesis GLB1 GO:0042398 amino_acid_derivative_biosynthesis EKI1 GO:0042219 amino_acid_derivative_catabolism INDO GO:0006575 amino_acid_derivative_metabolism TMLHE GO:0006575 amino_acid_derivative_metabolism CKMT2 GO:0006575 amino_acid_derivative_metabolism GLB1 GO:0006575 amino_acid_derivative_metabolism TTR GO:0006575 amino_acid_derivative_metabolism CKB GO:0006575 amino_acid_derivative_metabolism EKI1 GO:0006575 amino_acid_derivative_metabolism INDO GO:0006520 amino_acid_metabolism NARS GO:0006520 amino_acid_metabolism BCAT1 GO:0006520 amino_acid_metabolism WARS GO:0006520 amino_acid_metabolism PCBD GO:0006520 amino_acid_metabolism CDH16 GO:0006520 amino_acid_metabolism GFPT2

3:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006520 amino_acid_metabolism INDO GO:0006520 amino_acid_metabolism CBS GO:0015359 amino_acid_permease_activity SLC7A11 GO:0006865 amino_acid_transport SLC7A11 GO:0015171 amino_acid_transporter_activity SLC7A11 GO:0005279 amino_acid-polyamine_transporter_activity SLC7A11 GO:0006040 amino_sugar_metabolism GNE GO:0006022 aminoglycan_metabolism HS2ST1 GO:0004177 aminopeptidase_activity ENPEP GO:0004177 aminopeptidase_activity RNPEP GO:0030601 aminopeptidase_B_activity RNPEP GO:0016208 AMP_binding PRKAR2B GO:0016208 AMP_binding PRKAR2A GO:0003876 AMP_deaminase_activity AMPD2 GO:0004882 androgen_receptor_activity AR GO:0001525 angiogenesis EPAS1 GO:0001525 angiogenesis ADORA2B GO:0001595 angiotensin_receptor_activity AGTRAP GO:0004945 angiotensin_type_II_receptor_activity AGTRAP GO:0005253 anion_channel_activity CLIC6 GO:0006820 anion_transport SLC17A1 GO:0006820 anion_transport SLCO2A1 GO:0006820 anion_transport CLIC6 GO:0006820 anion_transport PTGER3 GO:0008509 anion_transporter_activity OCA2 GO:0008509 anion_transporter_activity SLC17A1 GO:0008509 anion_transporter_activity SLCO2A1 GO:0009952 anterior/posterior_pattern_formation EMX2 GO:0009952 anterior/posterior_pattern_formation EPHA3 GO:0009718 anthocyanin_biosynthesis GLB1 GO:0046283 anthocyanin_metabolism GLB1 GO:0006916 anti-apoptosis PRKAA1 GO:0006916 anti-apoptosis BIRC3 GO:0006916 anti-apoptosis IGF1 GO:0003823 antigen_binding IL27RA GO:0016209 antioxidant_activity AASS GO:0030121 AP-1_adaptor_complex APM2 GO:0030122 AP-2_adaptor_complex AP2B1 GO:0030122 AP-2_adaptor_complex APM2 GO:0016324 apical_plasma_membrane ANXA4 GO:0016324 apical_plasma_membrane MSN GO:0016327 apicolateral_plasma_membrane CALB2 GO:0016327 apicolateral_plasma_membrane PMP22 GO:0006915 apoptosis AHR GO:0006915 apoptosis PRKAA1 GO:0006915 apoptosis INHA GO:0006915 apoptosis CUL1 GO:0006915 apoptosis TNFRSF1A GO:0006915 apoptosis BIRC3 GO:0006915 apoptosis MAP3K5 GO:0006915 apoptosis CASP7 GO:0006915 apoptosis TRAF5 GO:0006915 apoptosis IGF1 GO:0006915 apoptosis APPBP1 GO:0009074 aromatic_amino_acid_family_catabolism INDO GO:0009072 aromatic_amino_acid_family_metabolism PCBD GO:0009072 aromatic_amino_acid_family_metabolism INDO GO:0019438 aromatic_compound_biosynthesis GLB1 GO:0019438 aromatic_compound_biosynthesis PCBD GO:0019439 aromatic_compound_catabolism INDO GO:0006725 aromatic_compound_metabolism FOLR1

4:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006725 aromatic_compound_metabolism GLB1 GO:0006725 aromatic_compound_metabolism PCBD GO:0006725 aromatic_compound_metabolism AMPD2 GO:0006725 aromatic_compound_metabolism INDO GO:0005885 Arp2/3_protein_complex ARPC1A GO:0015105 arsenite_transporter_activity OCA2 GO:0004816 asparagine-tRNA_ligase_activity NARS GO:0006421 asparaginyl-tRNA_aminoacylation NARS GO:0004815 aspartate-tRNA_ligase_activity NARS GO:0006422 aspartyl-tRNA_aminoacylation NARS GO:0005524 ATP_binding PRKAA1 GO:0005524 ATP_binding GK2 GO:0005524 ATP_binding NARS GO:0005524 ATP_binding UMPK GO:0005524 ATP_binding OCA2 GO:0005524 ATP_binding MAPK4 GO:0005524 ATP_binding WARS GO:0005524 ATP_binding ITM2B GO:0005524 ATP_binding EPHA3 GO:0005524 ATP_binding CDK8 GO:0005524 ATP_binding MAP3K5 GO:0005524 ATP_binding NRBP GO:0005524 ATP_binding MYH11 GO:0005524 ATP_binding ATP12A GO:0005524 ATP_binding SLC2A1 GO:0005524 ATP_binding CDH16 GO:0005524 ATP_binding TK1 GO:0005524 ATP_binding DDX20 GO:0005524 ATP_binding DDX25 GO:0005524 ATP_binding TESK2 GO:0005524 ATP_binding GNE GO:0005524 ATP_binding HSPA1A GO:0005524 ATP_binding CCT2 GO:0005524 ATP_binding DHX35 GO:0005524 ATP_binding ROR1 GO:0006754 ATP_biosynthesis ATP6V1E2 GO:0015991 ATP_hydrolysis_coupled_proton_transport ATP6V1E2 GO:0046034 ATP_metabolism ATP6V1E2 GO:0042773 ATP_synthesis_coupled_electron_transport NDUFB9 GO:0042775 ATP_synthesis_coupled_electron_transport_(sensu_Eukarya) NDUFB9 GO:0015986 ATP_synthesis_coupled_proton_transport ATP6V1E2 GO:0016887 ATPase_activity DDX25 GO:0016887 ATPase_activity ATP12A GO:0016887 ATPase_activity DDX20 GO:0016887 ATPase_activity ATP1B1 GO:0016887 ATPase_activity ATP6V1E2 GO:0042623 ATPase_activity,_coupled ATP12A GO:0042623 ATPase_activity,_coupled DDX25 GO:0042623 ATPase_activity,_coupled DDX20 GO:0042623 ATPase_activity,_coupled ATP1B1 GO:0042623 ATPase_activity,_coupled ATP6V1E2 GO:0042625 ATPase_activity,_coupled_to_transmembrane_movement_of_ions ATP12A GO:0042625 ATPase_activity,_coupled_to_transmembrane_movement_of_ions ATP1B1 GO:0042625 ATPase_activity,_coupled_to_transmembrane_movement_of_ions ATP6V1E2 GO:0015662 ATPase_activity,_coupled_to_transmembrane_movement_of_ions,_phosphorylati ATP12A GO:0015662 ATPase_activity,_coupled_to_transmembrane_movement_of_ions,_phosphorylati ATP1B1 GO:0015662 ATPase_activity,_coupled_to_transmembrane_movement_of_ions,_phosphorylati ATP6V1E2 GO:0042626 ATPase_activity,_coupled_to_transmembrane_movement_of_substances ATP12A GO:0042626 ATPase_activity,_coupled_to_transmembrane_movement_of_substances ATP1B1 GO:0042626 ATPase_activity,_coupled_to_transmembrane_movement_of_substances ATP6V1E2 GO:0001671 ATPase_stimulator_activity AHSA1

5:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008026 ATP-dependent_helicase_activity DDX25 GO:0008026 ATP-dependent_helicase_activity DDX20 GO:0007411 axon_guidance DSCAM GO:0008046 axon_guidance_receptor_activity DSCAM GO:0007409 axonogenesis STMN1 GO:0007409 axonogenesis DSCAM GO:0000917 barrier_septum_formation ACE2 GO:0005605 basal_lamina LAMB2 GO:0005604 basement_membrane COL4A6 GO:0005604 basement_membrane LAMB2 GO:0005604 basement_membrane COL4A5 GO:0016323 basolateral_plasma_membrane CDH17 GO:0016323 basolateral_plasma_membrane MSN GO:0042113 B-cell_activation INHA GO:0030183 B-cell_differentiation INHA GO:0007610 behavior CALB1 GO:0007610 behavior PRKAR2B GO:0007610 behavior ARNTL GO:0007610 behavior BHLHB3 GO:0007610 behavior CRH GO:0007610 behavior PTGDS GO:0004565 beta-galactosidase_activity GLB1 GO:0004565 beta-galactosidase_activity GAL GO:0009341 beta-galactosidase_complex GLB1 GO:0003836 beta-galactoside_alpha-2,3-sialyltransferase_activity SIAT4C GO:0004566 beta-glucuronidase_activity AFP GO:0015701 bicarbonate_transport PTGER3 GO:0005488 binding PRKAR2B GO:0005488 binding INHA GO:0005488 binding TLE4 GO:0005488 binding STAR GO:0005488 binding MTA3 GO:0005488 binding ENPEP GO:0005488 binding PAX5 GO:0005488 binding AHR GO:0005488 binding PARG GO:0005488 binding ANGPTL1 GO:0005488 binding AES GO:0005488 binding DDX20 GO:0005488 binding PLS3 GO:0005488 binding VLDLR GO:0005488 binding PTPRR GO:0005488 binding SIRT7 GO:0005488 binding DNMT3L GO:0005488 binding CART GO:0005488 binding APOE GO:0005488 binding NCALD GO:0005488 binding CX3CL1 GO:0005488 binding PRKAA1 GO:0005488 binding GK2 GO:0005488 binding HEBP1 GO:0005488 binding THBS2 GO:0005488 binding KLF12 GO:0005488 binding TLX2 GO:0005488 binding MLL GO:0005488 binding APEH GO:0005488 binding CDH17 GO:0005488 binding SRGAP2 GO:0005488 binding RPS8 GO:0005488 binding WARS GO:0005488 binding HESX1

6:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005488 binding PPP6C GO:0005488 binding CACNA1C GO:0005488 binding CLEC2 GO:0005488 binding TERF1 GO:0005488 binding MYH11 GO:0005488 binding YBX2 GO:0005488 binding RBPMS GO:0005488 binding ANXA4 GO:0005488 binding MS4A2 GO:0005488 binding HNF3B GO:0005488 binding CALB2 GO:0005488 binding FN1 GO:0005488 binding FOXA1 GO:0005488 binding ROR1 GO:0005488 binding IGF1 GO:0005488 binding SPAG5 GO:0005488 binding CALB1 GO:0005488 binding RPL18A GO:0005488 binding RPL28 GO:0005488 binding JARID2 GO:0005488 binding HNRPM GO:0005488 binding STX6 GO:0005488 binding HDGF GO:0005488 binding GAL GO:0005488 binding RRAS2 GO:0005488 binding SOX30 GO:0005488 binding OCA2 GO:0005488 binding MID1 GO:0005488 binding LYAR GO:0005488 binding ALPI GO:0005488 binding TRPS1 GO:0005488 binding PDZK1 GO:0005488 binding AP2B1 GO:0005488 binding PPP1R12B GO:0005488 binding CAPZB GO:0005488 binding PTPN13 GO:0005488 binding NR2F1 GO:0005488 binding GNB2L1 GO:0005488 binding FEM1B GO:0005488 binding SLC19A2 GO:0005488 binding ITGBL1 GO:0005488 binding LGALS8 GO:0005488 binding CUL1 GO:0005488 binding GNE GO:0005488 binding SHOX2 GO:0005488 binding PRNP GO:0005488 binding CCT2 GO:0005488 binding DHX35 GO:0005488 binding GFPT2 GO:0005488 binding BAZ1B GO:0005488 binding CHRDL2 GO:0005488 binding ARL4 GO:0005488 binding GADD45A GO:0005488 binding SOX14 GO:0005488 binding UMPK GO:0005488 binding EIF3S5 GO:0005488 binding BIRC3 GO:0005488 binding AFP GO:0005488 binding WISP2 GO:0005488 binding NAP1L1 GO:0005488 binding APM2

7:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005488 binding EPHA3 GO:0005488 binding MAP3K5 GO:0005488 binding BMP2 GO:0005488 binding GNA11 GO:0005488 binding VSNL1 GO:0005488 binding GNAI1 GO:0005488 binding TIP120B GO:0005488 binding TK1 GO:0005488 binding BRS3 GO:0005488 binding TNFRSF1A GO:0005488 binding PRKAR2A GO:0005488 binding PTGDS GO:0005488 binding DDX25 GO:0005488 binding HSPA1A GO:0005488 binding TCF8 GO:0005488 binding ANXA3 GO:0005488 binding NFIA GO:0005488 binding NARS GO:0005488 binding PTGER3 GO:0005488 binding H2AFY GO:0005488 binding TPD52L1 GO:0005488 binding TBX3 GO:0005488 binding ANXA9 GO:0005488 binding DRG1 GO:0005488 binding CRH GO:0005488 binding FOLR1 GO:0005488 binding SALL1 GO:0005488 binding RNPEP GO:0005488 binding CDK8 GO:0005488 binding POU5F1 GO:0005488 binding ASF1A GO:0005488 binding ARPC1A GO:0005488 binding CEBPD GO:0005488 binding CDH16 GO:0005488 binding PCBD GO:0005488 binding MT1A GO:0005488 binding H1F0 GO:0005488 binding HEY1 GO:0005488 binding IDI1 GO:0005488 binding TESK2 GO:0005488 binding ATBF1 GO:0005488 binding SERPINC1 GO:0005488 binding COL6A2 GO:0005488 binding VTN GO:0005488 binding TENR GO:0005488 binding PRND GO:0005488 binding DNMT3B GO:0005488 binding PRM2 GO:0005488 binding ETS2 GO:0005488 binding CAPZA3 GO:0005488 binding FABP5 GO:0005488 binding CDC42EP4 GO:0005488 binding CBFB GO:0005488 binding COL6A1 GO:0005488 binding HMGB2 GO:0005488 binding ADAMTS19 GO:0005488 binding SLC19A1 GO:0005488 binding GDF10 GO:0005488 binding APOA2 GO:0005488 binding SULT1E1 GO:0005488 binding NANOG

8:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005488 binding ARID3A GO:0005488 binding PAP GO:0005488 binding AGTRAP GO:0005488 binding ATP12A GO:0005488 binding TGFBI GO:0005488 binding ARNTL GO:0005488 binding F2 GO:0005488 binding LOXL1 GO:0005488 binding CALN1 GO:0005488 binding FEN1 GO:0005488 binding CGA GO:0005488 binding LRP10 GO:0005488 binding FHL2 GO:0005488 binding CBS GO:0005488 binding CCKBR GO:0005488 binding EPAS1 GO:0005488 binding SYCP2 GO:0005488 binding IL27RA GO:0005488 binding ITM2B GO:0005488 binding TNA GO:0005488 binding NRBP GO:0005488 binding CAPNS1 GO:0005488 binding ZFP36L2 GO:0005488 binding GRIN2D GO:0005488 binding PAX3 GO:0005488 binding PROSC GO:0005488 binding TCF7L2 GO:0005488 binding TLE1 GO:0005488 binding GRB14 GO:0005488 binding TBX2 GO:0005488 binding CETN3 GO:0005488 binding TTR GO:0005488 binding MT2A GO:0005488 binding BHLHB3 GO:0005488 binding EMX2 GO:0005488 binding CIRBP GO:0005488 binding DKK1 GO:0005488 binding MMP11 GO:0005488 binding S100A11 GO:0005488 binding MKRN1 GO:0005488 binding TCEA2 GO:0005488 binding PLSCR3 GO:0005488 binding SSBP1 GO:0005488 binding MAPK4 GO:0005488 binding PLEKHA1 GO:0005488 binding ID2 GO:0005488 binding NSEP1 GO:0005488 binding CADPS2 GO:0005488 binding SLC2A1 GO:0005488 binding HDLBP GO:0005488 binding KHDRBS3 GO:0005488 binding AR GO:0005488 binding OGN GO:0005488 binding GDF3 GO:0005488 binding INSL3 GO:0005488 binding TRAF5 GO:0005488 binding STMN1 GO:0005488 binding ZFP36L1 GO:0005488 binding BAP1 GO:0005488 binding LAMB2 GO:0005488 binding SORL1

9:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005488 binding MDK GO:0005488 binding FBLN1 GO:0045125 bioactive_lipid_receptor_activity GPR6 GO:0042401 biogenic_amine_biosynthesis TMLHE GO:0042401 biogenic_amine_biosynthesis EKI1 GO:0042402 biogenic_amine_catabolism INDO GO:0006576 biogenic_amine_metabolism TMLHE GO:0006576 biogenic_amine_metabolism TTR GO:0006576 biogenic_amine_metabolism EKI1 GO:0006576 biogenic_amine_metabolism INDO GO:0008150 biological_process PRKAR2B GO:0008150 biological_process INHA GO:0008150 biological_process TLE4 GO:0008150 biological_process CLIC6 GO:0008150 biological_process GSTA1 GO:0008150 biological_process STAR GO:0008150 biological_process SSPN GO:0008150 biological_process SPA17 GO:0008150 biological_process MTA3 GO:0008150 biological_process HSD17B1 GO:0008150 biological_process ENPEP GO:0008150 biological_process SLC2A3 GO:0008150 biological_process PAX5 GO:0008150 biological_process NUDT11 GO:0008150 biological_process CPR8 GO:0008150 biological_process FZD7 GO:0008150 biological_process AHR GO:0008150 biological_process PARG GO:0008150 biological_process PLAT GO:0008150 biological_process BCAT1 GO:0008150 biological_process PTPRK GO:0008150 biological_process ANGPTL1 GO:0008150 biological_process AES GO:0008150 biological_process DDX20 GO:0008150 biological_process PLS3 GO:0008150 biological_process PTPRR GO:0008150 biological_process VLDLR GO:0008150 biological_process ART3 GO:0008150 biological_process DNMT3L GO:0008150 biological_process SIRT7 GO:0008150 biological_process ACAS2L GO:0008150 biological_process NDUFB9 GO:0008150 biological_process CART GO:0008150 biological_process APOE GO:0008150 biological_process CX3CL1 GO:0008150 biological_process DNCL2A GO:0008150 biological_process PMP22 GO:0008150 biological_process PRKAA1 GO:0008150 biological_process CXXC4 GO:0008150 biological_process GK2 GO:0008150 biological_process HEBP1 GO:0008150 biological_process THBS2 GO:0008150 biological_process SEMA3E GO:0008150 biological_process KLF12 GO:0008150 biological_process SCN9A GO:0008150 biological_process BAG5 GO:0008150 biological_process TLX2 GO:0008150 biological_process MLL GO:0008150 biological_process APEH GO:0008150 biological_process TM4SF3 GO:0008150 biological_process PTGES

10:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008150 biological_process FXYD6 GO:0008150 biological_process CDH17 GO:0008150 biological_process SRGAP2 GO:0008150 biological_process WARS GO:0008150 biological_process RPS8 GO:0008150 biological_process HESX1 GO:0008150 biological_process CACNA1C GO:0008150 biological_process PPP6C GO:0008150 biological_process MPZ GO:0008150 biological_process CLEC2 GO:0008150 biological_process GGPS1 GO:0008150 biological_process MYH11 GO:0008150 biological_process TERF1 GO:0008150 biological_process ANXA4 GO:0008150 biological_process MS4A2 GO:0008150 biological_process HNF3B GO:0008150 biological_process COL1A2 GO:0008150 biological_process GMPR2 GO:0008150 biological_process SEMA6A GO:0008150 biological_process CRYAB GO:0008150 biological_process LDHA GO:0008150 biological_process AMBP GO:0008150 biological_process FN1 GO:0008150 biological_process FOXA1 GO:0008150 biological_process HES7 GO:0008150 biological_process COL14A1 GO:0008150 biological_process ROR1 GO:0008150 biological_process IGF1 GO:0008150 biological_process SPAG5 GO:0008150 biological_process GPC4 GO:0008150 biological_process CALB1 GO:0008150 biological_process DUSP6 GO:0008150 biological_process GSTP1 GO:0008150 biological_process RPL18A GO:0008150 biological_process CYP26A1 GO:0008150 biological_process RPL28 GO:0008150 biological_process JARID2 GO:0008150 biological_process STX6 GO:0008150 biological_process GAL GO:0008150 biological_process RRAS2 GO:0008150 biological_process SOX30 GO:0008150 biological_process OCA2 GO:0008150 biological_process MID1 GO:0008150 biological_process ELOVL4 GO:0008150 biological_process ALPI GO:0008150 biological_process TRPS1 GO:0008150 biological_process TLR8 GO:0008150 biological_process CBR1 GO:0008150 biological_process PDZK1 GO:0008150 biological_process CYP19A1 GO:0008150 biological_process MFAP4 GO:0008150 biological_process CASP7 GO:0008150 biological_process AP2B1 GO:0008150 biological_process PPP1R12B GO:0008150 biological_process GLB1 GO:0008150 biological_process SEMA5B GO:0008150 biological_process CAPZB GO:0008150 biological_process PTPN13 GO:0008150 biological_process NR2F1 GO:0008150 biological_process GNB2L1 GO:0008150 biological_process FEM1B

11:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008150 biological_process SLC19A2 GO:0008150 biological_process ITGBL1 GO:0008150 biological_process LGALS8 GO:0008150 biological_process CUL1 GO:0008150 biological_process GNE GO:0008150 biological_process SHOX2 GO:0008150 biological_process PRNP GO:0008150 biological_process CCT2 GO:0008150 biological_process APOB GO:0008150 biological_process GFPT2 GO:0008150 biological_process BAZ1B GO:0008150 biological_process CYP17A1 GO:0008150 biological_process COPE GO:0008150 biological_process CHRDL2 GO:0008150 biological_process GADD45A GO:0008150 biological_process ARL4 GO:0008150 biological_process UMPK GO:0008150 biological_process SOX14 GO:0008150 biological_process EIF3S5 GO:0008150 biological_process HS2ST1 GO:0008150 biological_process TAGLN GO:0008150 biological_process BIRC3 GO:0008150 biological_process SCAP2 GO:0008150 biological_process FAP GO:0008150 biological_process AFP GO:0008150 biological_process TMLHE GO:0008150 biological_process TAPBP GO:0008150 biological_process ARHGAP4 GO:0008150 biological_process WISP2 GO:0008150 biological_process NAP1L1 GO:0008150 biological_process APM2 GO:0008150 biological_process EPHA3 GO:0008150 biological_process MAP3K5 GO:0008150 biological_process CKMT2 GO:0008150 biological_process BMP2 GO:0008150 biological_process GNA11 GO:0008150 biological_process RACGAP1 GO:0008150 biological_process GNAI1 GO:0008150 biological_process CBR3 GO:0008150 biological_process APG3 GO:0008150 biological_process TK1 GO:0008150 biological_process BRS3 GO:0008150 biological_process AMPD2 GO:0008150 biological_process TNFRSF1A GO:0008150 biological_process MCF2 GO:0008150 biological_process PRKAR2A GO:0008150 biological_process DSCR1L2 GO:0008150 biological_process PTGDS GO:0008150 biological_process COL16A1 GO:0008150 biological_process HSPA1A GO:0008150 biological_process BFSP2 GO:0008150 biological_process SPRY1 GO:0008150 biological_process TCF8 GO:0008150 biological_process SCARB1 GO:0008150 biological_process EMP1 GO:0008150 biological_process NFIA GO:0008150 biological_process NARS GO:0008150 biological_process DSCAM GO:0008150 biological_process PTGER3 GO:0008150 biological_process GLA GO:0008150 biological_process H2AFY

12:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008150 biological_process TBX3 GO:0008150 biological_process ANXA9 GO:0008150 biological_process EKI1 GO:0008150 biological_process CRH GO:0008150 biological_process INDO GO:0008150 biological_process APPBP1 GO:0008150 biological_process ATIC GO:0008150 biological_process PGK1 GO:0008150 biological_process FOLR1 GO:0008150 biological_process COX6A2 GO:0008150 biological_process SALL1 GO:0008150 biological_process RNPEP GO:0008150 biological_process CDK8 GO:0008150 biological_process CDKN3 GO:0008150 biological_process LST1 GO:0008150 biological_process POU5F1 GO:0008150 biological_process ASF1A GO:0008150 biological_process PTPRD GO:0008150 biological_process NUDT1 GO:0008150 biological_process ARPC1A GO:0008150 biological_process BAMBI GO:0008150 biological_process CEBPD GO:0008150 biological_process PCBD GO:0008150 biological_process CDH16 GO:0008150 biological_process CKAP1 GO:0008150 biological_process MT1A GO:0008150 biological_process PRH1 GO:0008150 biological_process H1F0 GO:0008150 biological_process HEY1 GO:0008150 biological_process IDI1 GO:0008150 biological_process TESK2 GO:0008150 biological_process ATBF1 GO:0008150 biological_process SERPINC1 GO:0008150 biological_process COL4A5 GO:0008150 biological_process NQO1 GO:0008150 biological_process COL6A2 GO:0008150 biological_process UBA2 GO:0008150 biological_process VTN GO:0008150 biological_process AASS GO:0008150 biological_process TENR GO:0008150 biological_process COL5A2 GO:0008150 biological_process PWP1 GO:0008150 biological_process ATP1B1 GO:0008150 biological_process PRND GO:0008150 biological_process DNMT3B GO:0008150 biological_process PRM2 GO:0008150 biological_process ETS2 GO:0008150 biological_process CAPZA3 GO:0008150 biological_process FABP5 GO:0008150 biological_process CILP GO:0008150 biological_process CDC42EP4 GO:0008150 biological_process CBFB GO:0008150 biological_process COL6A1 GO:0008150 biological_process HMGB2 GO:0008150 biological_process PPIC GO:0008150 biological_process ADAMTS19 GO:0008150 biological_process ZMPSTE24 GO:0008150 biological_process GDF10 GO:0008150 biological_process SLC19A1 GO:0008150 biological_process APOA2 GO:0008150 biological_process ARID3A

13:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008150 biological_process NANOG GO:0008150 biological_process HSD3B1 GO:0008150 biological_process AGTRAP GO:0008150 biological_process PAP GO:0008150 biological_process ATP12A GO:0008150 biological_process TGFBI GO:0008150 biological_process SLC17A1 GO:0008150 biological_process COL4A6 GO:0008150 biological_process ARNTL GO:0008150 biological_process PDCL3 GO:0008150 biological_process RNF128 GO:0008150 biological_process GPR6 GO:0008150 biological_process F2 GO:0008150 biological_process LOXL1 GO:0008150 biological_process GLRX2 GO:0008150 biological_process CALN1 GO:0008150 biological_process FEN1 GO:0008150 biological_process MSN GO:0008150 biological_process LRP10 GO:0008150 biological_process FHL2 GO:0008150 biological_process CBS GO:0008150 biological_process CCKBR GO:0008150 biological_process EPAS1 GO:0008150 biological_process SIAT4C GO:0008150 biological_process GMPR GO:0008150 biological_process SYCP2 GO:0008150 biological_process LRRN3 GO:0008150 biological_process IL27RA GO:0008150 biological_process HSD3B2 GO:0008150 biological_process ITM2B GO:0008150 biological_process SLC7A11 GO:0008150 biological_process CKB GO:0008150 biological_process MGST1 GO:0008150 biological_process TNA GO:0008150 biological_process NRBP GO:0008150 biological_process RPL29 GO:0008150 biological_process GRIN2D GO:0008150 biological_process NOL6 GO:0008150 biological_process PAX3 GO:0008150 biological_process FZD4 GO:0008150 biological_process C6 GO:0008150 biological_process TCF7L2 GO:0008150 biological_process TLE1 GO:0008150 biological_process GRB14 GO:0008150 biological_process TBX2 GO:0008150 biological_process CITED1 GO:0008150 biological_process PAICS GO:0008150 biological_process CETN3 GO:0008150 biological_process ALDH1A3 GO:0008150 biological_process TTR GO:0008150 biological_process C1R GO:0008150 biological_process MT2A GO:0008150 biological_process BHLHB3 GO:0008150 biological_process EMX2 GO:0008150 biological_process COL1A1 GO:0008150 biological_process SLCO4A1 GO:0008150 biological_process CLC GO:0008150 biological_process CIRBP GO:0008150 biological_process DKK1 GO:0008150 biological_process GALC GO:0008150 biological_process SEMA4C

14:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008150 biological_process MMP11 GO:0008150 biological_process TCEA2 GO:0008150 biological_process COX7C GO:0008150 biological_process TNNT3 GO:0008150 biological_process GSTM3 GO:0008150 biological_process ARMC4 GO:0008150 biological_process SSBP1 GO:0008150 biological_process ATP6V1E2 GO:0008150 biological_process GGTLA1 GO:0008150 biological_process MLF1 GO:0008150 biological_process MAPK4 GO:0008150 biological_process LY6E GO:0008150 biological_process NRXN3 GO:0008150 biological_process FGG GO:0008150 biological_process ID2 GO:0008150 biological_process NSEP1 GO:0008150 biological_process CADPS2 GO:0008150 biological_process SUCLA2 GO:0008150 biological_process LIN28 GO:0008150 biological_process SLC2A1 GO:0008150 biological_process HDLBP GO:0008150 biological_process AHSA1 GO:0008150 biological_process AR GO:0008150 biological_process GPC3 GO:0008150 biological_process SEMA6D GO:0008150 biological_process TBPL1 GO:0008150 biological_process GDF3 GO:0008150 biological_process ELN GO:0008150 biological_process INSL3 GO:0008150 biological_process TRAF5 GO:0008150 biological_process STMN1 GO:0008150 biological_process GPR45 GO:0008150 biological_process BAP1 GO:0008150 biological_process LAMB2 GO:0008150 biological_process SLCO2A1 GO:0008150 biological_process ADORA2B GO:0008150 biological_process SORL1 GO:0008150 biological_process MDK GO:0008150 biological_process ACE2 GO:0008150 biological_process UPP1 GO:0008150 biological_process FBLN1 GO:0000004 biological_process_unknown CPR8 GO:0000004 biological_process_unknown LIN28 GO:0000004 biological_process_unknown TLE4 GO:0000004 biological_process_unknown NOL6 GO:0000004 biological_process_unknown AHSA1 GO:0000004 biological_process_unknown TBX3 GO:0000004 biological_process_unknown PWP1 GO:0000004 biological_process_unknown ANXA9 GO:0000004 biological_process_unknown SEMA6D GO:0000004 biological_process_unknown ARMC4 GO:0000004 biological_process_unknown SSBP1 GO:0000004 biological_process_unknown CILP GO:0000004 biological_process_unknown MTA3 GO:0000004 biological_process_unknown TAPBP GO:0000004 biological_process_unknown CALN1 GO:0000004 biological_process_unknown SRGAP2 GO:0000004 biological_process_unknown ARHGAP4 GO:0000004 biological_process_unknown CBR1 GO:0000004 biological_process_unknown ITM2B GO:0000004 biological_process_unknown SLCO4A1

15:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0000004 biological_process_unknown NUDT11 GO:0000004 biological_process_unknown MAP3K5 GO:0009058 biosynthesis CYP17A1 GO:0009058 biosynthesis PRKAA1 GO:0009058 biosynthesis INHA GO:0009058 biosynthesis NARS GO:0009058 biosynthesis RPL18A GO:0009058 biosynthesis GADD45A GO:0009058 biosynthesis UMPK GO:0009058 biosynthesis RPL28 GO:0009058 biosynthesis STAR GO:0009058 biosynthesis EIF3S5 GO:0009058 biosynthesis HS2ST1 GO:0009058 biosynthesis SIAT4C GO:0009058 biosynthesis EKI1 GO:0009058 biosynthesis ATP6V1E2 GO:0009058 biosynthesis ATIC GO:0009058 biosynthesis GGTLA1 GO:0009058 biosynthesis TMLHE GO:0009058 biosynthesis ELOVL4 GO:0009058 biosynthesis HSD17B1 GO:0009058 biosynthesis PGK1 GO:0009058 biosynthesis WARS GO:0009058 biosynthesis RPS8 GO:0009058 biosynthesis HSD3B2 GO:0009058 biosynthesis GGPS1 GO:0009058 biosynthesis HSD3B1 GO:0009058 biosynthesis RPL29 GO:0009058 biosynthesis CKMT2 GO:0009058 biosynthesis GLB1 GO:0009058 biosynthesis BCAT1 GO:0009058 biosynthesis RNF128 GO:0009058 biosynthesis CDH16 GO:0009058 biosynthesis PCBD GO:0009058 biosynthesis AMPD2 GO:0009058 biosynthesis TBPL1 GO:0009058 biosynthesis PTGDS GO:0009058 biosynthesis IDI1 GO:0009058 biosynthesis ACAS2L GO:0009058 biosynthesis PAICS GO:0009058 biosynthesis GNE GO:0009058 biosynthesis FEN1 GO:0009058 biosynthesis GFPT2 GO:0009058 biosynthesis CBS GO:0007596 blood_coagulation F2 GO:0007596 blood_coagulation FGG GO:0007596 blood_coagulation SERPINC1 GO:0007596 blood_coagulation TM4SF3 GO:0001568 blood_vessel_development EPAS1 GO:0001568 blood_vessel_development ADORA2B GO:0030509 BMP_signaling_pathway BMP2 GO:0030509 BMP_signaling_pathway BAMBI GO:0030509 BMP_signaling_pathway CHRDL2 GO:0004946 bombesin_receptor_activity BRS3 GO:0046849 bone_remodeling CBFB GO:0046849 bone_remodeling GDF10 GO:0046849 bone_remodeling COL1A1 GO:0007420 brain_development HESX1 GO:0007420 brain_development CKB GO:0007420 brain_development EMX2 GO:0007420 brain_development POU5F1

16:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007420 brain_development DKK1 GO:0009082 branched_chain_family_amino_acid_biosynthesis BCAT1 GO:0009081 branched_chain_family_amino_acid_metabolism BCAT1 GO:0004084 branched-chain-amino-acid_transaminase_activity BCAT1 GO:0006700 C21-steroid_hormone_biosynthesis CYP17A1 GO:0006700 C21-steroid_hormone_biosynthesis HSD3B2 GO:0006700 C21-steroid_hormone_biosynthesis STAR GO:0006700 C21-steroid_hormone_biosynthesis HSD3B1 GO:0008207 C21-steroid_hormone_metabolism AFP GO:0008207 C21-steroid_hormone_metabolism CYP17A1 GO:0008207 C21-steroid_hormone_metabolism HSD3B2 GO:0008207 C21-steroid_hormone_metabolism STAR GO:0008207 C21-steroid_hormone_metabolism HSD3B1 GO:0005262 calcium_channel_activity MID1 GO:0005262 calcium_channel_activity CACNA1C GO:0005509 calcium_ion_binding CALB1 GO:0005509 calcium_ion_binding MMP11 GO:0005509 calcium_ion_binding S100A11 GO:0005509 calcium_ion_binding THBS2 GO:0005509 calcium_ion_binding PLSCR3 GO:0005509 calcium_ion_binding ANXA9 GO:0005509 calcium_ion_binding MLL GO:0005509 calcium_ion_binding CDH17 GO:0005509 calcium_ion_binding WISP2 GO:0005509 calcium_ion_binding CACNA1C GO:0005509 calcium_ion_binding TNA GO:0005509 calcium_ion_binding CAPNS1 GO:0005509 calcium_ion_binding ANXA4 GO:0005509 calcium_ion_binding VSNL1 GO:0005509 calcium_ion_binding CDH16 GO:0005509 calcium_ion_binding PLS3 GO:0005509 calcium_ion_binding CALB2 GO:0005509 calcium_ion_binding VLDLR GO:0005509 calcium_ion_binding F2 GO:0005509 calcium_ion_binding CALN1 GO:0005509 calcium_ion_binding CETN3 GO:0005509 calcium_ion_binding LAMB2 GO:0005509 calcium_ion_binding NCALD GO:0005509 calcium_ion_binding ANXA3 GO:0005509 calcium_ion_binding FBLN1 GO:0005509 calcium_ion_binding CBS GO:0006816 calcium_ion_transport MID1 GO:0006816 calcium_ion_transport CACNA1C GO:0016339 calcium-dependent_cell-cell_adhesion CDH17 GO:0005544 calcium-dependent_phospholipid_binding ANXA4 GO:0005544 calcium-dependent_phospholipid_binding ANXA3 GO:0005544 calcium-dependent_phospholipid_binding ANXA9 GO:0004723 calcium-dependent_protein_serine/threonine_phosphatase_activity DUSP6 GO:0019722 calcium-mediated_signaling DSCR1L2 GO:0005516 calmodulin_binding MYH11 GO:0004683 calmodulin_regulated_protein_kinase_activity PGK1 GO:0004198 calpain_activity CAPNS1 GO:0004691 cAMP-dependent_protein_kinase_activity PRKAA1 GO:0004691 cAMP-dependent_protein_kinase_activity MAPK4 GO:0005952 cAMP-dependent_protein_kinase_complex PRKAR2B GO:0005952 cAMP-dependent_protein_kinase_complex PRKAR2A GO:0008603 cAMP-dependent_protein_kinase_regulator_activity SPA17 GO:0008603 cAMP-dependent_protein_kinase_regulator_activity PRKAR2B GO:0008603 cAMP-dependent_protein_kinase_regulator_activity PRKAR2A GO:0019933 cAMP-mediated_signaling PTGER3 GO:0030246 carbohydrate_binding LGALS8

17:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0030246 carbohydrate_binding CLEC2 GO:0030246 carbohydrate_binding TNA GO:0030246 carbohydrate_binding GFPT2 GO:0030246 carbohydrate_binding PAP GO:0016051 carbohydrate_biosynthesis PRKAA1 GO:0016051 carbohydrate_biosynthesis PGK1 GO:0016051 carbohydrate_biosynthesis GNE GO:0016051 carbohydrate_biosynthesis HS2ST1 GO:0016051 carbohydrate_biosynthesis GFPT2 GO:0016052 carbohydrate_catabolism SUCLA2 GO:0016052 carbohydrate_catabolism LDHA GO:0016052 carbohydrate_catabolism PARG GO:0016052 carbohydrate_catabolism PGK1 GO:0005975 carbohydrate_metabolism GALC GO:0005975 carbohydrate_metabolism LDHA GO:0005975 carbohydrate_metabolism SUCLA2 GO:0005975 carbohydrate_metabolism PRKAA1 GO:0005975 carbohydrate_metabolism GK2 GO:0005975 carbohydrate_metabolism PGK1 GO:0005975 carbohydrate_metabolism PARG GO:0005975 carbohydrate_metabolism GLB1 GO:0005975 carbohydrate_metabolism GNE GO:0005975 carbohydrate_metabolism GLA GO:0005975 carbohydrate_metabolism HS2ST1 GO:0005975 carbohydrate_metabolism GFPT2 GO:0008643 carbohydrate_transport PRKAA1 GO:0008643 carbohydrate_transport SLC2A1 GO:0008643 carbohydrate_transport SLC2A3 GO:0015144 carbohydrate_transporter_activity SLC2A1 GO:0015144 carbohydrate_transporter_activity SLC2A3 GO:0015144 carbohydrate_transporter_activity TBPL1 GO:0016830 carbon-carbon_lyase_activity PAICS GO:0016835 carbon-oxygen_lyase_activity PCBD GO:0016835 carbon-oxygen_lyase_activity CBS GO:0016846 carbon-sulfur_lyase_activity HCCS GO:0004090 carbonyl_reductase_(NADPH)_activity CBR1 GO:0004090 carbonyl_reductase_(NADPH)_activity CBR3 GO:0046394 carboxylic_acid_biosynthesis GGTLA1 GO:0046394 carboxylic_acid_biosynthesis PRKAA1 GO:0046394 carboxylic_acid_biosynthesis ACAS2L GO:0046394 carboxylic_acid_biosynthesis ELOVL4 GO:0046394 carboxylic_acid_biosynthesis FEN1 GO:0046394 carboxylic_acid_biosynthesis PTGDS GO:0019752 carboxylic_acid_metabolism PRKAA1 GO:0019752 carboxylic_acid_metabolism PRKAR2B GO:0019752 carboxylic_acid_metabolism NARS GO:0019752 carboxylic_acid_metabolism BCAT1 GO:0019752 carboxylic_acid_metabolism PCBD GO:0019752 carboxylic_acid_metabolism CDH16 GO:0019752 carboxylic_acid_metabolism TNFRSF1A GO:0019752 carboxylic_acid_metabolism PTGDS GO:0019752 carboxylic_acid_metabolism INDO GO:0019752 carboxylic_acid_metabolism PTGES GO:0019752 carboxylic_acid_metabolism TMLHE GO:0019752 carboxylic_acid_metabolism GGTLA1 GO:0019752 carboxylic_acid_metabolism ACAS2L GO:0019752 carboxylic_acid_metabolism ELOVL4 GO:0019752 carboxylic_acid_metabolism FOLR1 GO:0019752 carboxylic_acid_metabolism GNE GO:0019752 carboxylic_acid_metabolism WARS GO:0019752 carboxylic_acid_metabolism FEN1

18:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0019752 carboxylic_acid_metabolism GFPT2 GO:0019752 carboxylic_acid_metabolism CBS GO:0046942 carboxylic_acid_transport SLCO2A1 GO:0046942 carboxylic_acid_transport SLC7A11 GO:0046943 carboxylic_acid_transporter_activity SLCO2A1 GO:0046943 carboxylic_acid_transporter_activity SLC7A11 GO:0016789 carboxylic_ester_hydrolase_activity WISP2 GO:0016789 carboxylic_ester_hydrolase_activity LAMB2 GO:0016831 carboxy-lyase_activity PAICS GO:0004180 carboxypeptidase_activity ACE2 GO:0045329 carnitine_biosynthesis TMLHE GO:0009437 carnitine_metabolism TMLHE GO:0016117 carotenoid_biosynthesis IDI1 GO:0016116 carotenoid_metabolism IDI1 GO:0005386 carrier_activity ATP12A GO:0005386 carrier_activity SLC2A1 GO:0005386 carrier_activity SLC17A1 GO:0005386 carrier_activity COX7C GO:0005386 carrier_activity ATP1B1 GO:0005386 carrier_activity TBPL1 GO:0005386 carrier_activity ATP6V1E2 GO:0005386 carrier_activity AFP GO:0005386 carrier_activity SLC19A2 GO:0005386 carrier_activity NDUFB9 GO:0005386 carrier_activity CDH17 GO:0005386 carrier_activity TTR GO:0005386 carrier_activity COX6A2 GO:0005386 carrier_activity SLC7A11 GO:0005386 carrier_activity SLC2A3 GO:0005386 carrier_activity SLC19A1 GO:0004680 casein_kinase_activity MAPK4 GO:0030693 caspase_activity CASP7 GO:0009056 catabolism SPAG5 GO:0009056 catabolism GALC GO:0009056 catabolism UBA2 GO:0009056 catabolism MMP11 GO:0009056 catabolism TENR GO:0009056 catabolism FAP GO:0009056 catabolism INDO GO:0009056 catabolism APEH GO:0009056 catabolism PGK1 GO:0009056 catabolism COL6A1 GO:0009056 catabolism WISP2 GO:0009056 catabolism ENPEP GO:0009056 catabolism ADAMTS19 GO:0009056 catabolism ZMPSTE24 GO:0009056 catabolism RNPEP GO:0009056 catabolism CASP7 GO:0009056 catabolism SUCLA2 GO:0009056 catabolism NUDT1 GO:0009056 catabolism PARG GO:0009056 catabolism PLAT GO:0009056 catabolism ARNTL GO:0009056 catabolism RNF128 GO:0009056 catabolism GMPR2 GO:0009056 catabolism LDHA GO:0009056 catabolism F2 GO:0009056 catabolism BAP1 GO:0009056 catabolism LAMB2 GO:0009056 catabolism C1R GO:0009056 catabolism ACE2

19:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0003824 catalytic_activity PRKAR2B GO:0003824 catalytic_activity NARS GO:0003824 catalytic_activity GSTA1 GO:0003824 catalytic_activity GLA GO:0003824 catalytic_activity EKI1 GO:0003824 catalytic_activity APPBP1 GO:0003824 catalytic_activity INDO GO:0003824 catalytic_activity HCCS GO:0003824 catalytic_activity MGST2 GO:0003824 catalytic_activity ATIC GO:0003824 catalytic_activity HSD17B1 GO:0003824 catalytic_activity PGK1 GO:0003824 catalytic_activity COX6A2 GO:0003824 catalytic_activity ENPEP GO:0003824 catalytic_activity WBSCR22 GO:0003824 catalytic_activity NUDT11 GO:0003824 catalytic_activity RNPEP GO:0003824 catalytic_activity CDK8 GO:0003824 catalytic_activity CDKN3 GO:0003824 catalytic_activity CPR8 GO:0003824 catalytic_activity FZD7 GO:0003824 catalytic_activity PTPRD GO:0003824 catalytic_activity NUDT1 GO:0003824 catalytic_activity PARG GO:0003824 catalytic_activity BCAT1 GO:0003824 catalytic_activity PLAT GO:0003824 catalytic_activity PTPRK GO:0003824 catalytic_activity CDH16 GO:0003824 catalytic_activity PCBD GO:0003824 catalytic_activity DDX20 GO:0003824 catalytic_activity PRH1 GO:0003824 catalytic_activity PTPRR GO:0003824 catalytic_activity ART3 GO:0003824 catalytic_activity SIRT7 GO:0003824 catalytic_activity IDI1 GO:0003824 catalytic_activity TESK2 GO:0003824 catalytic_activity ACAS2L GO:0003824 catalytic_activity NDUFB9 GO:0003824 catalytic_activity NQO1 GO:0003824 catalytic_activity PRKAA1 GO:0003824 catalytic_activity UBA2 GO:0003824 catalytic_activity GK2 GO:0003824 catalytic_activity AASS GO:0003824 catalytic_activity TENR GO:0003824 catalytic_activity ATP1B1 GO:0003824 catalytic_activity DNMT3B GO:0003824 catalytic_activity APEH GO:0003824 catalytic_activity PTGES GO:0003824 catalytic_activity GSTA2 GO:0003824 catalytic_activity COL6A1 GO:0003824 catalytic_activity WARS GO:0003824 catalytic_activity PPIC GO:0003824 catalytic_activity ADAMTS19 GO:0003824 catalytic_activity PPP6C GO:0003824 catalytic_activity ZMPSTE24 GO:0003824 catalytic_activity GGPS1 GO:0003824 catalytic_activity SULT1E1 GO:0003824 catalytic_activity HSD3B1 GO:0003824 catalytic_activity ATP12A GO:0003824 catalytic_activity DHRS10 GO:0003824 catalytic_activity RNF128

20:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0003824 catalytic_activity GMPR2 GO:0003824 catalytic_activity LDHA GO:0003824 catalytic_activity F2 GO:0003824 catalytic_activity NUDT10 GO:0003824 catalytic_activity OPLAH GO:0003824 catalytic_activity LOXL1 GO:0003824 catalytic_activity FN1 GO:0003824 catalytic_activity FEN1 GO:0003824 catalytic_activity MSN GO:0003824 catalytic_activity ROR1 GO:0003824 catalytic_activity CBS GO:0003824 catalytic_activity SPAG5 GO:0003824 catalytic_activity DUSP6 GO:0003824 catalytic_activity GSTP1 GO:0003824 catalytic_activity CYP26A1 GO:0003824 catalytic_activity SIAT4C GO:0003824 catalytic_activity GAL GO:0003824 catalytic_activity RRAS2 GO:0003824 catalytic_activity GMPR GO:0003824 catalytic_activity OCA2 GO:0003824 catalytic_activity ALPI GO:0003824 catalytic_activity HSD3B2 GO:0003824 catalytic_activity CBR1 GO:0003824 catalytic_activity CKB GO:0003824 catalytic_activity MGST1 GO:0003824 catalytic_activity CYP19A1 GO:0003824 catalytic_activity CASP7 GO:0003824 catalytic_activity NRBP GO:0003824 catalytic_activity MGAT5 GO:0003824 catalytic_activity CAPNS1 GO:0003824 catalytic_activity GLB1 GO:0003824 catalytic_activity PROSC GO:0003824 catalytic_activity PTPN13 GO:0003824 catalytic_activity GNE GO:0003824 catalytic_activity PAICS GO:0003824 catalytic_activity ALDH1A3 GO:0003824 catalytic_activity C1R GO:0003824 catalytic_activity CCT2 GO:0003824 catalytic_activity DHX35 GO:0003824 catalytic_activity GFPT2 GO:0003824 catalytic_activity CYP17A1 GO:0003824 catalytic_activity GALC GO:0003824 catalytic_activity MMP11 GO:0003824 catalytic_activity ARL4 GO:0003824 catalytic_activity UMPK GO:0003824 catalytic_activity HS2ST1 GO:0003824 catalytic_activity COX7C GO:0003824 catalytic_activity GSTM3 GO:0003824 catalytic_activity FAP GO:0003824 catalytic_activity ATP6V1E2 GO:0003824 catalytic_activity AFP GO:0003824 catalytic_activity GGTLA1 GO:0003824 catalytic_activity TMLHE GO:0003824 catalytic_activity MAPK4 GO:0003824 catalytic_activity TPST2 GO:0003824 catalytic_activity WISP2 GO:0003824 catalytic_activity EPHA3 GO:0003824 catalytic_activity MAP3K5 GO:0003824 catalytic_activity SUCLA2 GO:0003824 catalytic_activity CKMT2 GO:0003824 catalytic_activity GNA11

21:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0003824 catalytic_activity GNAI1 GO:0003824 catalytic_activity CBR3 GO:0003824 catalytic_activity TK1 GO:0003824 catalytic_activity AMPD2 GO:0003824 catalytic_activity PRKAR2A GO:0003824 catalytic_activity PTGDS GO:0003824 catalytic_activity DDX25 GO:0003824 catalytic_activity BAP1 GO:0003824 catalytic_activity LAMB2 GO:0003824 catalytic_activity ACE2 GO:0003824 catalytic_activity UPP1 GO:0005261 cation_channel_activity MID1 GO:0005261 cation_channel_activity GRIN2D GO:0005261 cation_channel_activity CACNA1C GO:0005261 cation_channel_activity SCN9A GO:0030003 cation_homeostasis PRNP GO:0030003 cation_homeostasis MT2A GO:0030003 cation_homeostasis PRND GO:0030003 cation_homeostasis MT1A GO:0006812 cation_transport ATP12A GO:0006812 cation_transport MID1 GO:0006812 cation_transport SLC17A1 GO:0006812 cation_transport CACNA1C GO:0006812 cation_transport SCN9A GO:0006812 cation_transport ATP1B1 GO:0006812 cation_transport ATP6V1E2 GO:0008324 cation_transporter_activity ATP12A GO:0008324 cation_transporter_activity NDUFB9 GO:0008324 cation_transporter_activity COX6A2 GO:0008324 cation_transporter_activity COX7C GO:0008324 cation_transporter_activity ATP1B1 GO:0008324 cation_transporter_activity ATP6V1E2 GO:0005623 cell TLE4 GO:0005623 cell CLIC6 GO:0005623 cell STAR GO:0005623 cell SSR1 GO:0005623 cell SSPN GO:0005623 cell SPA17 GO:0005623 cell MTA3 GO:0005623 cell ENPEP GO:0005623 cell PAX5 GO:0005623 cell SLC2A3 GO:0005623 cell WBSCR22 GO:0005623 cell CPR8 GO:0005623 cell FZD7 GO:0005623 cell AHR GO:0005623 cell PARG GO:0005623 cell PTPRK GO:0005623 cell AES GO:0005623 cell DDX20 GO:0005623 cell PTPRR GO:0005623 cell VLDLR GO:0005623 cell DNMT3L GO:0005623 cell SIRT7 GO:0005623 cell ACAS2L GO:0005623 cell NDUFB9 GO:0005623 cell CX3CL1 GO:0005623 cell DNCL2A GO:0005623 cell PMP22 GO:0005623 cell CXXC4 GO:0005623 cell PRKAA1

22:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005623 cell GK2 GO:0005623 cell HEBP1 GO:0005623 cell SCN9A GO:0005623 cell KLF12 GO:0005623 cell IFITM1 GO:0005623 cell TLX2 GO:0005623 cell MLL GO:0005623 cell APEH GO:0005623 cell PTGES GO:0005623 cell FXYD6 GO:0005623 cell CDH17 GO:0005623 cell RPS8 GO:0005623 cell TBC1D1 GO:0005623 cell HESX1 GO:0005623 cell CACNA1C GO:0005623 cell MPZ GO:0005623 cell MYOZ2 GO:0005623 cell CLEC2 GO:0005623 cell GGPS1 GO:0005623 cell TERF1 GO:0005623 cell MYH11 GO:0005623 cell YBX2 GO:0005623 cell ANXA4 GO:0005623 cell MS4A2 GO:0005623 cell HNF3B GO:0005623 cell CALB2 GO:0005623 cell SEMA6A GO:0005623 cell CRYAB GO:0005623 cell AMBP GO:0005623 cell FOXA1 GO:0005623 cell ROR1 GO:0005623 cell SPAG5 GO:0005623 cell GPC4 GO:0005623 cell DUSP6 GO:0005623 cell CALB1 GO:0005623 cell RPL18A GO:0005623 cell EGFL6 GO:0005623 cell CYP26A1 GO:0005623 cell RPL28 GO:0005623 cell JARID2 GO:0005623 cell HNRPM GO:0005623 cell STX6 GO:0005623 cell HDGF GO:0005623 cell RRAS2 GO:0005623 cell SOX30 GO:0005623 cell OCA2 GO:0005623 cell MID1 GO:0005623 cell ELOVL4 GO:0005623 cell ALPI GO:0005623 cell LYAR GO:0005623 cell TRPS1 GO:0005623 cell TLR8 GO:0005623 cell CBR1 GO:0005623 cell LRIG1 GO:0005623 cell CYP19A1 GO:0005623 cell AP2B1 GO:0005623 cell GLB1 GO:0005623 cell GLIPR1 GO:0005623 cell SEMA5B GO:0005623 cell PTPN13 GO:0005623 cell CAPZB

23:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005623 cell NR2F1 GO:0005623 cell SLC19A2 GO:0005623 cell ITGBL1 GO:0005623 cell DCTN2 GO:0005623 cell CUL1 GO:0005623 cell PRNP GO:0005623 cell SHOX2 GO:0005623 cell CCT2 GO:0005623 cell APOB GO:0005623 cell BAZ1B GO:0005623 cell GFPT2 GO:0005623 cell CYP17A1 GO:0005623 cell COPE GO:0005623 cell ARL4 GO:0005623 cell GADD45A GO:0005623 cell SOX14 GO:0005623 cell BIRC3 GO:0005623 cell SCAP2 GO:0005623 cell FAP GO:0005623 cell TMLHE GO:0005623 cell TAPBP GO:0005623 cell JAM2 GO:0005623 cell TPST2 GO:0005623 cell WISP2 GO:0005623 cell NAP1L1 GO:0005623 cell APM2 GO:0005623 cell EPHA3 GO:0005623 cell CKMT2 GO:0005623 cell GNA11 GO:0005623 cell CBR3 GO:0005623 cell BRS3 GO:0005623 cell TIP120B GO:0005623 cell TK1 GO:0005623 cell TNFRSF1A GO:0005623 cell PRKAR2A GO:0005623 cell PTGDS GO:0005623 cell SPRY1 GO:0005623 cell TCF8 GO:0005623 cell SCARB1 GO:0005623 cell EMP1 GO:0005623 cell NFIA GO:0005623 cell NARS GO:0005623 cell DSCAM GO:0005623 cell PTGER3 GO:0005623 cell GLA GO:0005623 cell TPD52L1 GO:0005623 cell H2AFY GO:0005623 cell TBX3 GO:0005623 cell EKI1 GO:0005623 cell HCCS GO:0005623 cell FLRT3 GO:0005623 cell FOLR1 GO:0005623 cell PGK1 GO:0005623 cell COX6A2 GO:0005623 cell SALL1 GO:0005623 cell ROPN1 GO:0005623 cell CDK8 GO:0005623 cell POU5F1 GO:0005623 cell LST1 GO:0005623 cell ASF1A GO:0005623 cell PTPRD

24:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005623 cell ARPC1A GO:0005623 cell BAMBI GO:0005623 cell CEBPD GO:0005623 cell PCBD GO:0005623 cell CDH16 GO:0005623 cell CKAP1 GO:0005623 cell PRH1 GO:0005623 cell MT1A GO:0005623 cell H1F0 GO:0005623 cell HEY1 GO:0005623 cell IDI1 GO:0005623 cell TESK2 GO:0005623 cell ATBF1 GO:0005623 cell COL4A5 GO:0005623 cell UBA2 GO:0005623 cell AASS GO:0005623 cell TENR GO:0005623 cell PWP1 GO:0005623 cell ATP1B1 GO:0005623 cell DNMT3B GO:0005623 cell PRM2 GO:0005623 cell CAPZA3 GO:0005623 cell ETS2 GO:0005623 cell CDC42EP4 GO:0005623 cell CBFB GO:0005623 cell HMGB2 GO:0005623 cell SLC19A1 GO:0005623 cell ZMPSTE24 GO:0005623 cell NANOG GO:0005623 cell ARID3A GO:0005623 cell HSD3B1 GO:0005623 cell ATP12A GO:0005623 cell SLC17A1 GO:0005623 cell ARNTL GO:0005623 cell RNF128 GO:0005623 cell GPR6 GO:0005623 cell MSN GO:0005623 cell FEN1 GO:0005623 cell LRP10 GO:0005623 cell FHL2 GO:0005623 cell CCKBR GO:0005623 cell CBS GO:0005623 cell EPAS1 GO:0005623 cell SIAT4C GO:0005623 cell GPM6B GO:0005623 cell SYCP2 GO:0005623 cell HSD3B2 GO:0005623 cell SLC7A11 GO:0005623 cell ITM2B GO:0005623 cell CKB GO:0005623 cell MGST1 GO:0005623 cell NRBP GO:0005623 cell EPPK1 GO:0005623 cell RPL29 GO:0005623 cell MGAT5 GO:0005623 cell GRIN2D GO:0005623 cell ZFP36L2 GO:0005623 cell NOL6 GO:0005623 cell PAX3 GO:0005623 cell GPC5 GO:0005623 cell FZD4

25:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005623 cell IFNGR2 GO:0005623 cell TLE1 GO:0005623 cell TCF7L2 GO:0005623 cell TBX2 GO:0005623 cell CITED1 GO:0005623 cell CETN3 GO:0005623 cell BHLHB3 GO:0005623 cell EMX2 GO:0005623 cell SLCO4A1 GO:0005623 cell CLC GO:0005623 cell CIRBP GO:0005623 cell SEMA4C GO:0005623 cell GALC GO:0005623 cell TCEA2 GO:0005623 cell PLSCR3 GO:0005623 cell TNNT3 GO:0005623 cell COX7C GO:0005623 cell SSBP1 GO:0005623 cell ATP6V1E2 GO:0005623 cell GGTLA1 GO:0005623 cell MLF1 GO:0005623 cell MAPK4 GO:0005623 cell LY6E GO:0005623 cell NRXN3 GO:0005623 cell PLEKHA1 GO:0005623 cell ID2 GO:0005623 cell NSEP1 GO:0005623 cell CADPS2 GO:0005623 cell SUCLA2 GO:0005623 cell LIN28 GO:0005623 cell SLC2A1 GO:0005623 cell HDLBP GO:0005623 cell AR GO:0005623 cell GPC3 GO:0005623 cell TBPL1 GO:0005623 cell STMN1 GO:0005623 cell GPR45 GO:0005623 cell ZFP36L1 GO:0005623 cell BAP1 GO:0005623 cell SLCO2A1 GO:0005623 cell LAMB2 GO:0005623 cell ADORA2B GO:0005623 cell SORL1 GO:0005623 cell ACE2 GO:0001775 cell_activation INHA GO:0001775 cell_activation CBFB GO:0001775 cell_activation GAL GO:0007155 cell_adhesion COL6A2 GO:0007155 cell_adhesion VTN GO:0007155 cell_adhesion DSCAM GO:0007155 cell_adhesion THBS2 GO:0007155 cell_adhesion COL5A2 GO:0007155 cell_adhesion COL6A1 GO:0007155 cell_adhesion CDH17 GO:0007155 cell_adhesion WISP2 GO:0007155 cell_adhesion NRXN3 GO:0007155 cell_adhesion CLEC2 GO:0007155 cell_adhesion MFAP4 GO:0007155 cell_adhesion TNA GO:0007155 cell_adhesion PAP GO:0007155 cell_adhesion TGFBI

26:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007155 cell_adhesion COL1A2 GO:0007155 cell_adhesion CDH16 GO:0007155 cell_adhesion ITGBL1 GO:0007155 cell_adhesion COL16A1 GO:0007155 cell_adhesion LGALS8 GO:0007155 cell_adhesion FN1 GO:0007155 cell_adhesion LAMB2 GO:0007155 cell_adhesion CX3CL1 GO:0007155 cell_adhesion COL14A1 GO:0007155 cell_adhesion COL1A1 GO:0007155 cell_adhesion SCARB1 GO:0007155 cell_adhesion COL4A5 GO:0007154 cell_communication INHA GO:0007154 cell_communication PRKAR2B GO:0007154 cell_communication TLE4 GO:0007154 cell_communication DSCAM GO:0007154 cell_communication EPAS1 GO:0007154 cell_communication PTGER3 GO:0007154 cell_communication GAL GO:0007154 cell_communication RRAS2 GO:0007154 cell_communication OCA2 GO:0007154 cell_communication SPA17 GO:0007154 cell_communication LRRN3 GO:0007154 cell_communication PDZK1 GO:0007154 cell_communication MFAP4 GO:0007154 cell_communication TNA GO:0007154 cell_communication NRBP GO:0007154 cell_communication FZD7 GO:0007154 cell_communication AHR GO:0007154 cell_communication PTPRD GO:0007154 cell_communication GRIN2D GO:0007154 cell_communication BAMBI GO:0007154 cell_communication PTPRK GO:0007154 cell_communication ANGPTL1 GO:0007154 cell_communication CDH16 GO:0007154 cell_communication FZD4 GO:0007154 cell_communication PTPN13 GO:0007154 cell_communication MT1A GO:0007154 cell_communication TLE1 GO:0007154 cell_communication TCF7L2 GO:0007154 cell_communication GNB2L1 GO:0007154 cell_communication PTPRR GO:0007154 cell_communication SLC19A2 GO:0007154 cell_communication ITGBL1 GO:0007154 cell_communication LGALS8 GO:0007154 cell_communication GRB14 GO:0007154 cell_communication CART GO:0007154 cell_communication CX3CL1 GO:0007154 cell_communication COL1A1 GO:0007154 cell_communication CLC GO:0007154 cell_communication DKK1 GO:0007154 cell_communication COL4A5 GO:0007154 cell_communication COL6A2 GO:0007154 cell_communication PRKAA1 GO:0007154 cell_communication CXXC4 GO:0007154 cell_communication VTN GO:0007154 cell_communication CHRDL2 GO:0007154 cell_communication ARL4 GO:0007154 cell_communication THBS2 GO:0007154 cell_communication COL5A2 GO:0007154 cell_communication CDC42EP4

27:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007154 cell_communication COL6A1 GO:0007154 cell_communication CDH17 GO:0007154 cell_communication WISP2 GO:0007154 cell_communication NRXN3 GO:0007154 cell_communication APM2 GO:0007154 cell_communication EPHA3 GO:0007154 cell_communication CLEC2 GO:0007154 cell_communication PAP GO:0007154 cell_communication TGFBI GO:0007154 cell_communication SLC2A1 GO:0007154 cell_communication BMP2 GO:0007154 cell_communication GNA11 GO:0007154 cell_communication RACGAP1 GO:0007154 cell_communication MS4A2 GO:0007154 cell_communication ARNTL GO:0007154 cell_communication COL1A2 GO:0007154 cell_communication GNAI1 GO:0007154 cell_communication BRS3 GO:0007154 cell_communication TNFRSF1A GO:0007154 cell_communication PRKAR2A GO:0007154 cell_communication DSCR1L2 GO:0007154 cell_communication GPR6 GO:0007154 cell_communication TRAF5 GO:0007154 cell_communication STMN1 GO:0007154 cell_communication COL16A1 GO:0007154 cell_communication GPR45 GO:0007154 cell_communication FN1 GO:0007154 cell_communication MSN GO:0007154 cell_communication LAMB2 GO:0007154 cell_communication SPRY1 GO:0007154 cell_communication ADORA2B GO:0007154 cell_communication HES7 GO:0007154 cell_communication COL14A1 GO:0007154 cell_communication SCARB1 GO:0007154 cell_communication CCKBR GO:0007154 cell_communication IGF1 GO:0007049 cell_cycle TERF1 GO:0007049 cell_cycle SPAG5 GO:0007049 cell_cycle AHR GO:0007049 cell_cycle INHA GO:0007049 cell_cycle GADD45A GO:0007049 cell_cycle NR2F1 GO:0007049 cell_cycle SSBP1 GO:0007049 cell_cycle PRM2 GO:0007049 cell_cycle SYCP2 GO:0007049 cell_cycle ETS2 GO:0007049 cell_cycle SSPN GO:0007049 cell_cycle STMN1 GO:0007049 cell_cycle CUL1 GO:0007049 cell_cycle MAPK4 GO:0007049 cell_cycle CETN3 GO:0007049 cell_cycle FEN1 GO:0007049 cell_cycle PPP6C GO:0007049 cell_cycle MDK GO:0007049 cell_cycle ID2 GO:0007049 cell_cycle ACE2 GO:0007049 cell_cycle PMP22 GO:0007049 cell_cycle CDK8 GO:0007049 cell_cycle NFIA GO:0007049 cell_cycle CDKN3 GO:0007050 cell_cycle_arrest INHA

28:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007050 cell_cycle_arrest GADD45A GO:0007050 cell_cycle_arrest PMP22 GO:0007050 cell_cycle_arrest CDKN3 GO:0008219 cell_death AHR GO:0008219 cell_death PRKAA1 GO:0008219 cell_death INHA GO:0008219 cell_death CUL1 GO:0008219 cell_death TNFRSF1A GO:0008219 cell_death BIRC3 GO:0008219 cell_death MAP3K5 GO:0008219 cell_death CASP7 GO:0008219 cell_death TRAF5 GO:0008219 cell_death IGF1 GO:0008219 cell_death APPBP1 GO:0048468 cell_development MSN GO:0048468 cell_development PMP22 GO:0030154 cell_differentiation DUSP6 GO:0030154 cell_differentiation BMP2 GO:0030154 cell_differentiation INHA GO:0030154 cell_differentiation CHRDL2 GO:0030154 cell_differentiation AES GO:0030154 cell_differentiation GMPR2 GO:0030154 cell_differentiation TBPL1 GO:0030154 cell_differentiation PRM2 GO:0030154 cell_differentiation MLF1 GO:0030154 cell_differentiation CBFB GO:0030154 cell_differentiation MSN GO:0030154 cell_differentiation MDK GO:0030154 cell_differentiation PAX5 GO:0030154 cell_differentiation EMX2 GO:0030154 cell_differentiation PMP22 GO:0030154 cell_differentiation IGF1 GO:0045165 cell_fate_commitment BMP2 GO:0045165 cell_fate_commitment AES GO:0001709 cell_fate_determination AES GO:0000267 cell_fraction NARS GO:0000267 cell_fraction DSCAM GO:0000267 cell_fraction CYP26A1 GO:0000267 cell_fraction HNRPM GO:0000267 cell_fraction PTGES GO:0000267 cell_fraction AMBP GO:0000267 cell_fraction TAPBP GO:0000267 cell_fraction FOLR1 GO:0000267 cell_fraction CBR1 GO:0000267 cell_fraction ITM2B GO:0000267 cell_fraction ZMPSTE24 GO:0000267 cell_fraction APOB GO:0000267 cell_fraction MGST1 GO:0016049 cell_growth WISP2 GO:0016049 cell_growth EMP1 GO:0008151 cell_growth_and/or_maintenance INHA GO:0008151 cell_growth_and/or_maintenance PRKAR2B GO:0008151 cell_growth_and/or_maintenance DSCAM GO:0008151 cell_growth_and/or_maintenance CLIC6 GO:0008151 cell_growth_and/or_maintenance PTGER3 GO:0008151 cell_growth_and/or_maintenance H2AFY GO:0008151 cell_growth_and/or_maintenance STAR GO:0008151 cell_growth_and/or_maintenance SSPN GO:0008151 cell_growth_and/or_maintenance FOLR1 GO:0008151 cell_growth_and/or_maintenance SLC2A3 GO:0008151 cell_growth_and/or_maintenance CDK8

29:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008151 cell_growth_and/or_maintenance LST1 GO:0008151 cell_growth_and/or_maintenance CDKN3 GO:0008151 cell_growth_and/or_maintenance POU5F1 GO:0008151 cell_growth_and/or_maintenance ASF1A GO:0008151 cell_growth_and/or_maintenance AHR GO:0008151 cell_growth_and/or_maintenance ARPC1A GO:0008151 cell_growth_and/or_maintenance CKAP1 GO:0008151 cell_growth_and/or_maintenance PLS3 GO:0008151 cell_growth_and/or_maintenance PRH1 GO:0008151 cell_growth_and/or_maintenance MT1A GO:0008151 cell_growth_and/or_maintenance H1F0 GO:0008151 cell_growth_and/or_maintenance VLDLR GO:0008151 cell_growth_and/or_maintenance SIRT7 GO:0008151 cell_growth_and/or_maintenance APOE GO:0008151 cell_growth_and/or_maintenance DNCL2A GO:0008151 cell_growth_and/or_maintenance PMP22 GO:0008151 cell_growth_and/or_maintenance PRKAA1 GO:0008151 cell_growth_and/or_maintenance COL5A2 GO:0008151 cell_growth_and/or_maintenance SCN9A GO:0008151 cell_growth_and/or_maintenance PRND GO:0008151 cell_growth_and/or_maintenance ATP1B1 GO:0008151 cell_growth_and/or_maintenance PRM2 GO:0008151 cell_growth_and/or_maintenance CAPZA3 GO:0008151 cell_growth_and/or_maintenance ETS2 GO:0008151 cell_growth_and/or_maintenance FABP5 GO:0008151 cell_growth_and/or_maintenance CDC42EP4 GO:0008151 cell_growth_and/or_maintenance FXYD6 GO:0008151 cell_growth_and/or_maintenance CDH17 GO:0008151 cell_growth_and/or_maintenance HMGB2 GO:0008151 cell_growth_and/or_maintenance RPS8 GO:0008151 cell_growth_and/or_maintenance CACNA1C GO:0008151 cell_growth_and/or_maintenance PPP6C GO:0008151 cell_growth_and/or_maintenance SLC19A1 GO:0008151 cell_growth_and/or_maintenance MPZ GO:0008151 cell_growth_and/or_maintenance APOA2 GO:0008151 cell_growth_and/or_maintenance NANOG GO:0008151 cell_growth_and/or_maintenance TERF1 GO:0008151 cell_growth_and/or_maintenance MYH11 GO:0008151 cell_growth_and/or_maintenance ATP12A GO:0008151 cell_growth_and/or_maintenance ANXA4 GO:0008151 cell_growth_and/or_maintenance SLC17A1 GO:0008151 cell_growth_and/or_maintenance ARNTL GO:0008151 cell_growth_and/or_maintenance AMBP GO:0008151 cell_growth_and/or_maintenance FN1 GO:0008151 cell_growth_and/or_maintenance MSN GO:0008151 cell_growth_and/or_maintenance FEN1 GO:0008151 cell_growth_and/or_maintenance LRP10 GO:0008151 cell_growth_and/or_maintenance SPAG5 GO:0008151 cell_growth_and/or_maintenance RPL28 GO:0008151 cell_growth_and/or_maintenance STX6 GO:0008151 cell_growth_and/or_maintenance GAL GO:0008151 cell_growth_and/or_maintenance RRAS2 GO:0008151 cell_growth_and/or_maintenance SYCP2 GO:0008151 cell_growth_and/or_maintenance LRRN3 GO:0008151 cell_growth_and/or_maintenance MID1 GO:0008151 cell_growth_and/or_maintenance SLC7A11 GO:0008151 cell_growth_and/or_maintenance PDZK1 GO:0008151 cell_growth_and/or_maintenance RPL29 GO:0008151 cell_growth_and/or_maintenance AP2B1 GO:0008151 cell_growth_and/or_maintenance GRIN2D GO:0008151 cell_growth_and/or_maintenance CAPZB

30:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008151 cell_growth_and/or_maintenance NR2F1 GO:0008151 cell_growth_and/or_maintenance SLC19A2 GO:0008151 cell_growth_and/or_maintenance CUL1 GO:0008151 cell_growth_and/or_maintenance CETN3 GO:0008151 cell_growth_and/or_maintenance PRNP GO:0008151 cell_growth_and/or_maintenance TTR GO:0008151 cell_growth_and/or_maintenance MT2A GO:0008151 cell_growth_and/or_maintenance CCT2 GO:0008151 cell_growth_and/or_maintenance CLC GO:0008151 cell_growth_and/or_maintenance SLCO4A1 GO:0008151 cell_growth_and/or_maintenance APOB GO:0008151 cell_growth_and/or_maintenance BAZ1B GO:0008151 cell_growth_and/or_maintenance GFPT2 GO:0008151 cell_growth_and/or_maintenance COPE GO:0008151 cell_growth_and/or_maintenance GADD45A GO:0008151 cell_growth_and/or_maintenance ARL4 GO:0008151 cell_growth_and/or_maintenance TAGLN GO:0008151 cell_growth_and/or_maintenance SCAP2 GO:0008151 cell_growth_and/or_maintenance SSBP1 GO:0008151 cell_growth_and/or_maintenance ATP6V1E2 GO:0008151 cell_growth_and/or_maintenance AFP GO:0008151 cell_growth_and/or_maintenance MAPK4 GO:0008151 cell_growth_and/or_maintenance WISP2 GO:0008151 cell_growth_and/or_maintenance NAP1L1 GO:0008151 cell_growth_and/or_maintenance APM2 GO:0008151 cell_growth_and/or_maintenance ID2 GO:0008151 cell_growth_and/or_maintenance CADPS2 GO:0008151 cell_growth_and/or_maintenance BMP2 GO:0008151 cell_growth_and/or_maintenance SLC2A1 GO:0008151 cell_growth_and/or_maintenance HDLBP GO:0008151 cell_growth_and/or_maintenance AR GO:0008151 cell_growth_and/or_maintenance APG3 GO:0008151 cell_growth_and/or_maintenance PRKAR2A GO:0008151 cell_growth_and/or_maintenance GDF3 GO:0008151 cell_growth_and/or_maintenance ELN GO:0008151 cell_growth_and/or_maintenance PTGDS GO:0008151 cell_growth_and/or_maintenance TRAF5 GO:0008151 cell_growth_and/or_maintenance STMN1 GO:0008151 cell_growth_and/or_maintenance BAP1 GO:0008151 cell_growth_and/or_maintenance HSPA1A GO:0008151 cell_growth_and/or_maintenance SLCO2A1 GO:0008151 cell_growth_and/or_maintenance BFSP2 GO:0008151 cell_growth_and/or_maintenance SORL1 GO:0008151 cell_growth_and/or_maintenance ACE2 GO:0008151 cell_growth_and/or_maintenance MDK GO:0008151 cell_growth_and/or_maintenance EMP1 GO:0008151 cell_growth_and/or_maintenance NFIA GO:0019725 cell_homeostasis BAP1 GO:0019725 cell_homeostasis PRNP GO:0019725 cell_homeostasis MT2A GO:0019725 cell_homeostasis ACE2 GO:0019725 cell_homeostasis PRND GO:0019725 cell_homeostasis MT1A GO:0006873 cell_ion_homeostasis PRNP GO:0006873 cell_ion_homeostasis MT2A GO:0006873 cell_ion_homeostasis ACE2 GO:0006873 cell_ion_homeostasis MT1A GO:0006873 cell_ion_homeostasis PRND GO:0030054 cell_junction CALB2 GO:0030054 cell_junction PMP22 GO:0048469 cell_maturation PMP22

31:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0016477 cell_migration DSCAM GO:0016477 cell_migration GPC3 GO:0042074 cell_migration_during_gastrulation GPC3 GO:0006928 cell_motility MYH11 GO:0006928 cell_motility DSCAM GO:0006928 cell_motility TNNT3 GO:0006928 cell_motility GPC3 GO:0016043 cell_organization_and_biogenesis RPL28 GO:0016043 cell_organization_and_biogenesis H2AFY GO:0016043 cell_organization_and_biogenesis TAGLN GO:0016043 cell_organization_and_biogenesis PRM2 GO:0016043 cell_organization_and_biogenesis CAPZA3 GO:0016043 cell_organization_and_biogenesis CDC42EP4 GO:0016043 cell_organization_and_biogenesis MAPK4 GO:0016043 cell_organization_and_biogenesis HMGB2 GO:0016043 cell_organization_and_biogenesis WISP2 GO:0016043 cell_organization_and_biogenesis RPS8 GO:0016043 cell_organization_and_biogenesis NAP1L1 GO:0016043 cell_organization_and_biogenesis PPP6C GO:0016043 cell_organization_and_biogenesis MPZ GO:0016043 cell_organization_and_biogenesis LST1 GO:0016043 cell_organization_and_biogenesis TERF1 GO:0016043 cell_organization_and_biogenesis ASF1A GO:0016043 cell_organization_and_biogenesis MYH11 GO:0016043 cell_organization_and_biogenesis RPL29 GO:0016043 cell_organization_and_biogenesis ARPC1A GO:0016043 cell_organization_and_biogenesis CKAP1 GO:0016043 cell_organization_and_biogenesis APG3 GO:0016043 cell_organization_and_biogenesis PLS3 GO:0016043 cell_organization_and_biogenesis PRH1 GO:0016043 cell_organization_and_biogenesis CAPZB GO:0016043 cell_organization_and_biogenesis H1F0 GO:0016043 cell_organization_and_biogenesis ELN GO:0016043 cell_organization_and_biogenesis STMN1 GO:0016043 cell_organization_and_biogenesis SIRT7 GO:0016043 cell_organization_and_biogenesis FN1 GO:0016043 cell_organization_and_biogenesis HSPA1A GO:0016043 cell_organization_and_biogenesis MSN GO:0016043 cell_organization_and_biogenesis BFSP2 GO:0016043 cell_organization_and_biogenesis DNCL2A GO:0016043 cell_organization_and_biogenesis CCT2 GO:0016043 cell_organization_and_biogenesis EMP1 GO:0016043 cell_organization_and_biogenesis BAZ1B GO:0008283 cell_proliferation SPAG5 GO:0008283 cell_proliferation PRKAR2B GO:0008283 cell_proliferation INHA GO:0008283 cell_proliferation DSCAM GO:0008283 cell_proliferation GADD45A GO:0008283 cell_proliferation SCAP2 GO:0008283 cell_proliferation GAL GO:0008283 cell_proliferation SYCP2 GO:0008283 cell_proliferation PRM2 GO:0008283 cell_proliferation SSBP1 GO:0008283 cell_proliferation ETS2 GO:0008283 cell_proliferation SSPN GO:0008283 cell_proliferation MAPK4 GO:0008283 cell_proliferation WISP2 GO:0008283 cell_proliferation PPP6C GO:0008283 cell_proliferation ID2 GO:0008283 cell_proliferation CDK8 GO:0008283 cell_proliferation NANOG

32:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008283 cell_proliferation CDKN3 GO:0008283 cell_proliferation TERF1 GO:0008283 cell_proliferation AHR GO:0008283 cell_proliferation NR2F1 GO:0008283 cell_proliferation TRAF5 GO:0008283 cell_proliferation STMN1 GO:0008283 cell_proliferation CUL1 GO:0008283 cell_proliferation BAP1 GO:0008283 cell_proliferation CETN3 GO:0008283 cell_proliferation FEN1 GO:0008283 cell_proliferation MDK GO:0008283 cell_proliferation ACE2 GO:0008283 cell_proliferation PMP22 GO:0008283 cell_proliferation NFIA GO:0009986 cell_surface MS4A2 GO:0009986 cell_surface WISP2 GO:0009986 cell_surface PRNP GO:0007166 cell_surface_receptor_linked_signal_transduction CXXC4 GO:0007166 cell_surface_receptor_linked_signal_transduction INHA GO:0007166 cell_surface_receptor_linked_signal_transduction TLE4 GO:0007166 cell_surface_receptor_linked_signal_transduction CHRDL2 GO:0007166 cell_surface_receptor_linked_signal_transduction PTGER3 GO:0007166 cell_surface_receptor_linked_signal_transduction GAL GO:0007166 cell_surface_receptor_linked_signal_transduction CLEC2 GO:0007166 cell_surface_receptor_linked_signal_transduction EPHA3 GO:0007166 cell_surface_receptor_linked_signal_transduction FZD7 GO:0007166 cell_surface_receptor_linked_signal_transduction GNA11 GO:0007166 cell_surface_receptor_linked_signal_transduction BMP2 GO:0007166 cell_surface_receptor_linked_signal_transduction PTPRD GO:0007166 cell_surface_receptor_linked_signal_transduction BAMBI GO:0007166 cell_surface_receptor_linked_signal_transduction GNAI1 GO:0007166 cell_surface_receptor_linked_signal_transduction PTPRK GO:0007166 cell_surface_receptor_linked_signal_transduction ANGPTL1 GO:0007166 cell_surface_receptor_linked_signal_transduction FZD4 GO:0007166 cell_surface_receptor_linked_signal_transduction BRS3 GO:0007166 cell_surface_receptor_linked_signal_transduction TNFRSF1A GO:0007166 cell_surface_receptor_linked_signal_transduction TLE1 GO:0007166 cell_surface_receptor_linked_signal_transduction TCF7L2 GO:0007166 cell_surface_receptor_linked_signal_transduction GNB2L1 GO:0007166 cell_surface_receptor_linked_signal_transduction PTPRR GO:0007166 cell_surface_receptor_linked_signal_transduction GPR6 GO:0007166 cell_surface_receptor_linked_signal_transduction SLC19A2 GO:0007166 cell_surface_receptor_linked_signal_transduction ITGBL1 GO:0007166 cell_surface_receptor_linked_signal_transduction GRB14 GO:0007166 cell_surface_receptor_linked_signal_transduction GPR45 GO:0007166 cell_surface_receptor_linked_signal_transduction CART GO:0007166 cell_surface_receptor_linked_signal_transduction ADORA2B GO:0007166 cell_surface_receptor_linked_signal_transduction HES7 GO:0007166 cell_surface_receptor_linked_signal_transduction DKK1 GO:0007166 cell_surface_receptor_linked_signal_transduction IGF1 GO:0007166 cell_surface_receptor_linked_signal_transduction CCKBR GO:0016337 cell-cell_adhesion LGALS8 GO:0016337 cell-cell_adhesion CDH17 GO:0016337 cell-cell_adhesion CDH16 GO:0016337 cell-cell_adhesion CLEC2 GO:0016337 cell-cell_adhesion TNA GO:0016337 cell-cell_adhesion PAP GO:0007267 cell-cell_signaling GNA11 GO:0007267 cell-cell_signaling INHA GO:0007267 cell-cell_signaling GRIN2D GO:0007267 cell-cell_signaling CART

33:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007267 cell-cell_signaling APM2 GO:0007267 cell-cell_signaling CLC GO:0007160 cell-matrix_adhesion ITGBL1 GO:0042087 cell-mediated_immune_response INHA GO:0007044 cell-substrate_junction_assembly FN1 GO:0005575 cellular_component PRKAR2B GO:0005575 cellular_component INHA GO:0005575 cellular_component TLE4 GO:0005575 cellular_component CLIC6 GO:0005575 cellular_component STAR GO:0005575 cellular_component SSR1 GO:0005575 cellular_component SSPN GO:0005575 cellular_component SPA17 GO:0005575 cellular_component MTA3 GO:0005575 cellular_component ENPEP GO:0005575 cellular_component PAX5 GO:0005575 cellular_component SLC2A3 GO:0005575 cellular_component NUDT11 GO:0005575 cellular_component WBSCR22 GO:0005575 cellular_component CPR8 GO:0005575 cellular_component FZD7 GO:0005575 cellular_component AHR GO:0005575 cellular_component PARG GO:0005575 cellular_component PLAT GO:0005575 cellular_component PTPRK GO:0005575 cellular_component ANGPTL1 GO:0005575 cellular_component AES GO:0005575 cellular_component DDX20 GO:0005575 cellular_component VLDLR GO:0005575 cellular_component PTPRR GO:0005575 cellular_component ART3 GO:0005575 cellular_component SIRT7 GO:0005575 cellular_component DNMT3L GO:0005575 cellular_component ACAS2L GO:0005575 cellular_component NDUFB9 GO:0005575 cellular_component CART GO:0005575 cellular_component APOE GO:0005575 cellular_component CX3CL1 GO:0005575 cellular_component DNCL2A GO:0005575 cellular_component PMP22 GO:0005575 cellular_component CXXC4 GO:0005575 cellular_component PRKAA1 GO:0005575 cellular_component GK2 GO:0005575 cellular_component HEBP1 GO:0005575 cellular_component THBS2 GO:0005575 cellular_component SEMA3E GO:0005575 cellular_component SCN9A GO:0005575 cellular_component KLF12 GO:0005575 cellular_component BAG5 GO:0005575 cellular_component IFITM1 GO:0005575 cellular_component TLX2 GO:0005575 cellular_component MLL GO:0005575 cellular_component APEH GO:0005575 cellular_component PTGES GO:0005575 cellular_component FXYD6 GO:0005575 cellular_component SRGAP2 GO:0005575 cellular_component CDH17 GO:0005575 cellular_component RPS8 GO:0005575 cellular_component TBC1D1 GO:0005575 cellular_component HESX1 GO:0005575 cellular_component CACNA1C

34:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005575 cellular_component MPZ GO:0005575 cellular_component MYOZ2 GO:0005575 cellular_component CLEC2 GO:0005575 cellular_component GGPS1 GO:0005575 cellular_component MYH11 GO:0005575 cellular_component TERF1 GO:0005575 cellular_component YBX2 GO:0005575 cellular_component ANXA4 GO:0005575 cellular_component MS4A2 GO:0005575 cellular_component COL1A2 GO:0005575 cellular_component HNF3B GO:0005575 cellular_component CALB2 GO:0005575 cellular_component GMPR2 GO:0005575 cellular_component SEMA6A GO:0005575 cellular_component CRYAB GO:0005575 cellular_component AMBP GO:0005575 cellular_component FN1 GO:0005575 cellular_component FOXA1 GO:0005575 cellular_component COL14A1 GO:0005575 cellular_component HES7 GO:0005575 cellular_component ROR1 GO:0005575 cellular_component IGF1 GO:0005575 cellular_component SPAG5 GO:0005575 cellular_component CALB1 GO:0005575 cellular_component DUSP6 GO:0005575 cellular_component GPC4 GO:0005575 cellular_component RPL18A GO:0005575 cellular_component EGFL6 GO:0005575 cellular_component RPL28 GO:0005575 cellular_component CYP26A1 GO:0005575 cellular_component JARID2 GO:0005575 cellular_component STX6 GO:0005575 cellular_component HNRPM GO:0005575 cellular_component HDGF GO:0005575 cellular_component GAL GO:0005575 cellular_component RRAS2 GO:0005575 cellular_component SOX30 GO:0005575 cellular_component OCA2 GO:0005575 cellular_component MID1 GO:0005575 cellular_component ELOVL4 GO:0005575 cellular_component TRPS1 GO:0005575 cellular_component LYAR GO:0005575 cellular_component ALPI GO:0005575 cellular_component CRISP2 GO:0005575 cellular_component CBR1 GO:0005575 cellular_component TLR8 GO:0005575 cellular_component LRIG1 GO:0005575 cellular_component MFAP4 GO:0005575 cellular_component CYP19A1 GO:0005575 cellular_component AP2B1 GO:0005575 cellular_component GLB1 GO:0005575 cellular_component GLIPR1 GO:0005575 cellular_component SEMA5B GO:0005575 cellular_component CAPZB GO:0005575 cellular_component PTPN13 GO:0005575 cellular_component NR2F1 GO:0005575 cellular_component SLC19A2 GO:0005575 cellular_component ITGBL1 GO:0005575 cellular_component DCTN2 GO:0005575 cellular_component CUL1 GO:0005575 cellular_component SHOX2

35:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005575 cellular_component PRNP GO:0005575 cellular_component CCT2 GO:0005575 cellular_component APOB GO:0005575 cellular_component BAZ1B GO:0005575 cellular_component GFPT2 GO:0005575 cellular_component CYP17A1 GO:0005575 cellular_component CHRDL2 GO:0005575 cellular_component COPE GO:0005575 cellular_component ARL4 GO:0005575 cellular_component GADD45A GO:0005575 cellular_component SOX14 GO:0005575 cellular_component HS2ST1 GO:0005575 cellular_component BIRC3 GO:0005575 cellular_component SCAP2 GO:0005575 cellular_component FAP GO:0005575 cellular_component AFP GO:0005575 cellular_component TMLHE GO:0005575 cellular_component TAPBP GO:0005575 cellular_component JAM2 GO:0005575 cellular_component ARHGAP4 GO:0005575 cellular_component TPST2 GO:0005575 cellular_component WISP2 GO:0005575 cellular_component NAP1L1 GO:0005575 cellular_component APM2 GO:0005575 cellular_component EPHA3 GO:0005575 cellular_component MAP3K5 GO:0005575 cellular_component CKMT2 GO:0005575 cellular_component BMP2 GO:0005575 cellular_component GNA11 GO:0005575 cellular_component CBR3 GO:0005575 cellular_component BRS3 GO:0005575 cellular_component TIP120B GO:0005575 cellular_component TK1 GO:0005575 cellular_component TNFRSF1A GO:0005575 cellular_component PRKAR2A GO:0005575 cellular_component PTGDS GO:0005575 cellular_component COL16A1 GO:0005575 cellular_component SPRY1 GO:0005575 cellular_component TCF8 GO:0005575 cellular_component SCARB1 GO:0005575 cellular_component EMP1 GO:0005575 cellular_component NFIA GO:0005575 cellular_component NARS GO:0005575 cellular_component DSCAM GO:0005575 cellular_component PTGER3 GO:0005575 cellular_component GLA GO:0005575 cellular_component TPD52L1 GO:0005575 cellular_component H2AFY GO:0005575 cellular_component TBX3 GO:0005575 cellular_component ANXA9 GO:0005575 cellular_component EKI1 GO:0005575 cellular_component CRH GO:0005575 cellular_component HCCS GO:0005575 cellular_component FLRT3 GO:0005575 cellular_component FOLR1 GO:0005575 cellular_component PGK1 GO:0005575 cellular_component COX6A2 GO:0005575 cellular_component SALL1 GO:0005575 cellular_component ROPN1 GO:0005575 cellular_component CDK8 GO:0005575 cellular_component CDKN3

36:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005575 cellular_component POU5F1 GO:0005575 cellular_component LST1 GO:0005575 cellular_component ASF1A GO:0005575 cellular_component PTPRD GO:0005575 cellular_component NUDT1 GO:0005575 cellular_component ARPC1A GO:0005575 cellular_component BAMBI GO:0005575 cellular_component TBL2 GO:0005575 cellular_component CEBPD GO:0005575 cellular_component PCBD GO:0005575 cellular_component CDH16 GO:0005575 cellular_component CKAP1 GO:0005575 cellular_component PRH1 GO:0005575 cellular_component MT1A GO:0005575 cellular_component H1F0 GO:0005575 cellular_component HEY1 GO:0005575 cellular_component IDI1 GO:0005575 cellular_component TESK2 GO:0005575 cellular_component TIMP4 GO:0005575 cellular_component ATBF1 GO:0005575 cellular_component SERPINC1 GO:0005575 cellular_component COL4A5 GO:0005575 cellular_component COL6A2 GO:0005575 cellular_component VTN GO:0005575 cellular_component UBA2 GO:0005575 cellular_component AASS GO:0005575 cellular_component TENR GO:0005575 cellular_component COL5A2 GO:0005575 cellular_component PWP1 GO:0005575 cellular_component ATP1B1 GO:0005575 cellular_component DNMT3B GO:0005575 cellular_component PRM2 GO:0005575 cellular_component CAPZA3 GO:0005575 cellular_component ETS2 GO:0005575 cellular_component CILP GO:0005575 cellular_component CDC42EP4 GO:0005575 cellular_component CBFB GO:0005575 cellular_component COL6A1 GO:0005575 cellular_component HMGB2 GO:0005575 cellular_component PPIC GO:0005575 cellular_component ADAMTS19 GO:0005575 cellular_component GDF10 GO:0005575 cellular_component SLC19A1 GO:0005575 cellular_component ZMPSTE24 GO:0005575 cellular_component APOA2 GO:0005575 cellular_component NANOG GO:0005575 cellular_component ARID3A GO:0005575 cellular_component PAP GO:0005575 cellular_component HSD3B1 GO:0005575 cellular_component ATP12A GO:0005575 cellular_component TGFBI GO:0005575 cellular_component COL4A6 GO:0005575 cellular_component SLC17A1 GO:0005575 cellular_component ARNTL GO:0005575 cellular_component RNF128 GO:0005575 cellular_component GPR6 GO:0005575 cellular_component F2 GO:0005575 cellular_component LOXL1 GO:0005575 cellular_component CALN1 GO:0005575 cellular_component MSN GO:0005575 cellular_component FEN1

37:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005575 cellular_component CGA GO:0005575 cellular_component LRP10 GO:0005575 cellular_component FHL2 GO:0005575 cellular_component CCKBR GO:0005575 cellular_component CBS GO:0005575 cellular_component EPAS1 GO:0005575 cellular_component SIAT4C GO:0005575 cellular_component GPM6B GO:0005575 cellular_component SYCP2 GO:0005575 cellular_component LRRN3 GO:0005575 cellular_component IL27RA GO:0005575 cellular_component HSD3B2 GO:0005575 cellular_component ITM2B GO:0005575 cellular_component SLC7A11 GO:0005575 cellular_component CKB GO:0005575 cellular_component MGST1 GO:0005575 cellular_component TNA GO:0005575 cellular_component EPPK1 GO:0005575 cellular_component NRBP GO:0005575 cellular_component RPL29 GO:0005575 cellular_component MGAT5 GO:0005575 cellular_component ZFP36L2 GO:0005575 cellular_component GRIN2D GO:0005575 cellular_component NOL6 GO:0005575 cellular_component PAX3 GO:0005575 cellular_component GPC5 GO:0005575 cellular_component IFNGR2 GO:0005575 cellular_component FZD4 GO:0005575 cellular_component C6 GO:0005575 cellular_component TCF7L2 GO:0005575 cellular_component TLE1 GO:0005575 cellular_component TBX2 GO:0005575 cellular_component PAICS GO:0005575 cellular_component CETN3 GO:0005575 cellular_component CITED1 GO:0005575 cellular_component TTR GO:0005575 cellular_component C1R GO:0005575 cellular_component MT2A GO:0005575 cellular_component BHLHB3 GO:0005575 cellular_component EMX2 GO:0005575 cellular_component COL1A1 GO:0005575 cellular_component CLC GO:0005575 cellular_component SLCO4A1 GO:0005575 cellular_component CIRBP GO:0005575 cellular_component DKK1 GO:0005575 cellular_component GALC GO:0005575 cellular_component SEMA4C GO:0005575 cellular_component MMP11 GO:0005575 cellular_component TCEA2 GO:0005575 cellular_component COX7C GO:0005575 cellular_component TNNT3 GO:0005575 cellular_component PLSCR3 GO:0005575 cellular_component ARMC4 GO:0005575 cellular_component ATP6V1E2 GO:0005575 cellular_component SSBP1 GO:0005575 cellular_component GGTLA1 GO:0005575 cellular_component MLF1 GO:0005575 cellular_component MAPK4 GO:0005575 cellular_component LY6E GO:0005575 cellular_component NRXN3 GO:0005575 cellular_component PLEKHA1

38:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005575 cellular_component FGG GO:0005575 cellular_component ID2 GO:0005575 cellular_component CADPS2 GO:0005575 cellular_component NSEP1 GO:0005575 cellular_component SUCLA2 GO:0005575 cellular_component LIN28 GO:0005575 cellular_component SLC2A1 GO:0005575 cellular_component HDLBP GO:0005575 cellular_component AHSA1 GO:0005575 cellular_component AR GO:0005575 cellular_component GPC3 GO:0005575 cellular_component OGN GO:0005575 cellular_component SEMA6D GO:0005575 cellular_component GDF3 GO:0005575 cellular_component ELN GO:0005575 cellular_component TBPL1 GO:0005575 cellular_component INSL3 GO:0005575 cellular_component STMN1 GO:0005575 cellular_component ZFP36L1 GO:0005575 cellular_component GPR45 GO:0005575 cellular_component BAP1 GO:0005575 cellular_component LAMB2 GO:0005575 cellular_component SLCO2A1 GO:0005575 cellular_component SORL1 GO:0005575 cellular_component ADORA2B GO:0005575 cellular_component MDK GO:0005575 cellular_component ACE2 GO:0005575 cellular_component FBLN1 GO:0008372 cellular_component_unknown TLE4 GO:0008372 cellular_component_unknown AHSA1 GO:0008372 cellular_component_unknown TBX3 GO:0008372 cellular_component_unknown ANXA9 GO:0008372 cellular_component_unknown SEMA6D GO:0008372 cellular_component_unknown MT1A GO:0008372 cellular_component_unknown BAG5 GO:0008372 cellular_component_unknown ARMC4 GO:0008372 cellular_component_unknown GMPR2 GO:0008372 cellular_component_unknown SSBP1 GO:0008372 cellular_component_unknown CILP GO:0008372 cellular_component_unknown TAPBP GO:0008372 cellular_component_unknown CALN1 GO:0008372 cellular_component_unknown SRGAP2 GO:0008372 cellular_component_unknown BAP1 GO:0008372 cellular_component_unknown ARHGAP4 GO:0008372 cellular_component_unknown CBR1 GO:0008372 cellular_component_unknown MT2A GO:0008372 cellular_component_unknown HES7 GO:0008372 cellular_component_unknown SLCO4A1 GO:0008372 cellular_component_unknown NUDT11 GO:0008372 cellular_component_unknown MAP3K5 GO:0008372 cellular_component_unknown CDKN3 GO:0006968 cellular_defense_response INHA GO:0016066 cellular_defense_response_(sensu_Vertebrata) INHA GO:0000902 cellular_morphogenesis CDC42EP4 GO:0000902 cellular_morphogenesis ARPC1A GO:0000902 cellular_morphogenesis WISP2 GO:0000902 cellular_morphogenesis MSN GO:0000902 cellular_morphogenesis PPP6C GO:0000902 cellular_morphogenesis EMP1 GO:0000902 cellular_morphogenesis LST1 GO:0000904 cellular_morphogenesis_during_differentiation MSN

39:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0050875 cellular_physiological_process INHA GO:0050875 cellular_physiological_process PRKAR2B GO:0050875 cellular_physiological_process DSCAM GO:0050875 cellular_physiological_process CLIC6 GO:0050875 cellular_physiological_process PTGER3 GO:0050875 cellular_physiological_process H2AFY GO:0050875 cellular_physiological_process STAR GO:0050875 cellular_physiological_process APPBP1 GO:0050875 cellular_physiological_process SSPN GO:0050875 cellular_physiological_process FOLR1 GO:0050875 cellular_physiological_process SLC2A3 GO:0050875 cellular_physiological_process CDK8 GO:0050875 cellular_physiological_process POU5F1 GO:0050875 cellular_physiological_process LST1 GO:0050875 cellular_physiological_process CDKN3 GO:0050875 cellular_physiological_process ASF1A GO:0050875 cellular_physiological_process AHR GO:0050875 cellular_physiological_process ARPC1A GO:0050875 cellular_physiological_process CKAP1 GO:0050875 cellular_physiological_process PLS3 GO:0050875 cellular_physiological_process MT1A GO:0050875 cellular_physiological_process PRH1 GO:0050875 cellular_physiological_process H1F0 GO:0050875 cellular_physiological_process VLDLR GO:0050875 cellular_physiological_process SIRT7 GO:0050875 cellular_physiological_process APOE GO:0050875 cellular_physiological_process DNCL2A GO:0050875 cellular_physiological_process PMP22 GO:0050875 cellular_physiological_process PRKAA1 GO:0050875 cellular_physiological_process SCN9A GO:0050875 cellular_physiological_process COL5A2 GO:0050875 cellular_physiological_process ATP1B1 GO:0050875 cellular_physiological_process PRND GO:0050875 cellular_physiological_process PRM2 GO:0050875 cellular_physiological_process ETS2 GO:0050875 cellular_physiological_process CAPZA3 GO:0050875 cellular_physiological_process FABP5 GO:0050875 cellular_physiological_process CDC42EP4 GO:0050875 cellular_physiological_process FXYD6 GO:0050875 cellular_physiological_process CBFB GO:0050875 cellular_physiological_process CDH17 GO:0050875 cellular_physiological_process HMGB2 GO:0050875 cellular_physiological_process RPS8 GO:0050875 cellular_physiological_process CACNA1C GO:0050875 cellular_physiological_process PPP6C GO:0050875 cellular_physiological_process SLC19A1 GO:0050875 cellular_physiological_process MPZ GO:0050875 cellular_physiological_process APOA2 GO:0050875 cellular_physiological_process NANOG GO:0050875 cellular_physiological_process TERF1 GO:0050875 cellular_physiological_process MYH11 GO:0050875 cellular_physiological_process ATP12A GO:0050875 cellular_physiological_process ANXA4 GO:0050875 cellular_physiological_process COL4A6 GO:0050875 cellular_physiological_process SLC17A1 GO:0050875 cellular_physiological_process ARNTL GO:0050875 cellular_physiological_process AMBP GO:0050875 cellular_physiological_process FN1 GO:0050875 cellular_physiological_process MSN GO:0050875 cellular_physiological_process FEN1 GO:0050875 cellular_physiological_process LRP10

40:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0050875 cellular_physiological_process IGF1 GO:0050875 cellular_physiological_process SPAG5 GO:0050875 cellular_physiological_process RPL28 GO:0050875 cellular_physiological_process STX6 GO:0050875 cellular_physiological_process GAL GO:0050875 cellular_physiological_process RRAS2 GO:0050875 cellular_physiological_process SYCP2 GO:0050875 cellular_physiological_process LRRN3 GO:0050875 cellular_physiological_process MID1 GO:0050875 cellular_physiological_process SLC7A11 GO:0050875 cellular_physiological_process PDZK1 GO:0050875 cellular_physiological_process CASP7 GO:0050875 cellular_physiological_process RPL29 GO:0050875 cellular_physiological_process AP2B1 GO:0050875 cellular_physiological_process GRIN2D GO:0050875 cellular_physiological_process CAPZB GO:0050875 cellular_physiological_process NR2F1 GO:0050875 cellular_physiological_process SLC19A2 GO:0050875 cellular_physiological_process CUL1 GO:0050875 cellular_physiological_process CETN3 GO:0050875 cellular_physiological_process PRNP GO:0050875 cellular_physiological_process TTR GO:0050875 cellular_physiological_process MT2A GO:0050875 cellular_physiological_process BHLHB3 GO:0050875 cellular_physiological_process CCT2 GO:0050875 cellular_physiological_process CLC GO:0050875 cellular_physiological_process SLCO4A1 GO:0050875 cellular_physiological_process APOB GO:0050875 cellular_physiological_process BAZ1B GO:0050875 cellular_physiological_process GFPT2 GO:0050875 cellular_physiological_process COPE GO:0050875 cellular_physiological_process GADD45A GO:0050875 cellular_physiological_process ARL4 GO:0050875 cellular_physiological_process TNNT3 GO:0050875 cellular_physiological_process TAGLN GO:0050875 cellular_physiological_process SCAP2 GO:0050875 cellular_physiological_process BIRC3 GO:0050875 cellular_physiological_process ATP6V1E2 GO:0050875 cellular_physiological_process SSBP1 GO:0050875 cellular_physiological_process AFP GO:0050875 cellular_physiological_process MAPK4 GO:0050875 cellular_physiological_process WISP2 GO:0050875 cellular_physiological_process NAP1L1 GO:0050875 cellular_physiological_process APM2 GO:0050875 cellular_physiological_process ID2 GO:0050875 cellular_physiological_process MAP3K5 GO:0050875 cellular_physiological_process CADPS2 GO:0050875 cellular_physiological_process SLC2A1 GO:0050875 cellular_physiological_process BMP2 GO:0050875 cellular_physiological_process HDLBP GO:0050875 cellular_physiological_process APG3 GO:0050875 cellular_physiological_process AR GO:0050875 cellular_physiological_process GPC3 GO:0050875 cellular_physiological_process TNFRSF1A GO:0050875 cellular_physiological_process PRKAR2A GO:0050875 cellular_physiological_process ELN GO:0050875 cellular_physiological_process GDF3 GO:0050875 cellular_physiological_process PTGDS GO:0050875 cellular_physiological_process TRAF5 GO:0050875 cellular_physiological_process STMN1 GO:0050875 cellular_physiological_process BAP1

41:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0050875 cellular_physiological_process HSPA1A GO:0050875 cellular_physiological_process SLCO2A1 GO:0050875 cellular_physiological_process BFSP2 GO:0050875 cellular_physiological_process SORL1 GO:0050875 cellular_physiological_process MDK GO:0050875 cellular_physiological_process ACE2 GO:0050875 cellular_physiological_process EMP1 GO:0050875 cellular_physiological_process NFIA GO:0009987 cellular_process PRKAR2B GO:0009987 cellular_process INHA GO:0009987 cellular_process TLE4 GO:0009987 cellular_process DSCAM GO:0009987 cellular_process CLIC6 GO:0009987 cellular_process PTGER3 GO:0009987 cellular_process STAR GO:0009987 cellular_process H2AFY GO:0009987 cellular_process APPBP1 GO:0009987 cellular_process SSPN GO:0009987 cellular_process SPA17 GO:0009987 cellular_process FOLR1 GO:0009987 cellular_process SLC2A3 GO:0009987 cellular_process PAX5 GO:0009987 cellular_process CDK8 GO:0009987 cellular_process CDKN3 GO:0009987 cellular_process LST1 GO:0009987 cellular_process POU5F1 GO:0009987 cellular_process ASF1A GO:0009987 cellular_process FZD7 GO:0009987 cellular_process AHR GO:0009987 cellular_process PTPRD GO:0009987 cellular_process ARPC1A GO:0009987 cellular_process BAMBI GO:0009987 cellular_process PTPRK GO:0009987 cellular_process ANGPTL1 GO:0009987 cellular_process CDH16 GO:0009987 cellular_process AES GO:0009987 cellular_process CKAP1 GO:0009987 cellular_process PLS3 GO:0009987 cellular_process PRH1 GO:0009987 cellular_process MT1A GO:0009987 cellular_process H1F0 GO:0009987 cellular_process VLDLR GO:0009987 cellular_process PTPRR GO:0009987 cellular_process SIRT7 GO:0009987 cellular_process CART GO:0009987 cellular_process APOE GO:0009987 cellular_process DNCL2A GO:0009987 cellular_process CX3CL1 GO:0009987 cellular_process PMP22 GO:0009987 cellular_process COL4A5 GO:0009987 cellular_process COL6A2 GO:0009987 cellular_process VTN GO:0009987 cellular_process CXXC4 GO:0009987 cellular_process PRKAA1 GO:0009987 cellular_process THBS2 GO:0009987 cellular_process SCN9A GO:0009987 cellular_process COL5A2 GO:0009987 cellular_process PRND GO:0009987 cellular_process ATP1B1 GO:0009987 cellular_process PRM2 GO:0009987 cellular_process CAPZA3

42:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0009987 cellular_process ETS2 GO:0009987 cellular_process FABP5 GO:0009987 cellular_process CDC42EP4 GO:0009987 cellular_process FXYD6 GO:0009987 cellular_process CBFB GO:0009987 cellular_process COL6A1 GO:0009987 cellular_process CDH17 GO:0009987 cellular_process RPS8 GO:0009987 cellular_process HMGB2 GO:0009987 cellular_process PPP6C GO:0009987 cellular_process CACNA1C GO:0009987 cellular_process MPZ GO:0009987 cellular_process SLC19A1 GO:0009987 cellular_process APOA2 GO:0009987 cellular_process CLEC2 GO:0009987 cellular_process NANOG GO:0009987 cellular_process PAP GO:0009987 cellular_process MYH11 GO:0009987 cellular_process TERF1 GO:0009987 cellular_process ATP12A GO:0009987 cellular_process TGFBI GO:0009987 cellular_process ANXA4 GO:0009987 cellular_process SLC17A1 GO:0009987 cellular_process COL4A6 GO:0009987 cellular_process MS4A2 GO:0009987 cellular_process ARNTL GO:0009987 cellular_process COL1A2 GO:0009987 cellular_process GMPR2 GO:0009987 cellular_process GPR6 GO:0009987 cellular_process AMBP GO:0009987 cellular_process FN1 GO:0009987 cellular_process FEN1 GO:0009987 cellular_process MSN GO:0009987 cellular_process LRP10 GO:0009987 cellular_process HES7 GO:0009987 cellular_process COL14A1 GO:0009987 cellular_process CCKBR GO:0009987 cellular_process IGF1 GO:0009987 cellular_process SPAG5 GO:0009987 cellular_process DUSP6 GO:0009987 cellular_process EPAS1 GO:0009987 cellular_process RPL28 GO:0009987 cellular_process STX6 GO:0009987 cellular_process GAL GO:0009987 cellular_process RRAS2 GO:0009987 cellular_process SYCP2 GO:0009987 cellular_process LRRN3 GO:0009987 cellular_process OCA2 GO:0009987 cellular_process MID1 GO:0009987 cellular_process SLC7A11 GO:0009987 cellular_process PDZK1 GO:0009987 cellular_process MFAP4 GO:0009987 cellular_process CASP7 GO:0009987 cellular_process TNA GO:0009987 cellular_process NRBP GO:0009987 cellular_process RPL29 GO:0009987 cellular_process AP2B1 GO:0009987 cellular_process GRIN2D GO:0009987 cellular_process FZD4 GO:0009987 cellular_process CAPZB GO:0009987 cellular_process TCF7L2

43:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0009987 cellular_process TLE1 GO:0009987 cellular_process PTPN13 GO:0009987 cellular_process NR2F1 GO:0009987 cellular_process GNB2L1 GO:0009987 cellular_process SLC19A2 GO:0009987 cellular_process ITGBL1 GO:0009987 cellular_process LGALS8 GO:0009987 cellular_process GRB14 GO:0009987 cellular_process CUL1 GO:0009987 cellular_process CETN3 GO:0009987 cellular_process TTR GO:0009987 cellular_process PRNP GO:0009987 cellular_process MT2A GO:0009987 cellular_process BHLHB3 GO:0009987 cellular_process CCT2 GO:0009987 cellular_process EMX2 GO:0009987 cellular_process COL1A1 GO:0009987 cellular_process APOB GO:0009987 cellular_process SLCO4A1 GO:0009987 cellular_process CLC GO:0009987 cellular_process GFPT2 GO:0009987 cellular_process BAZ1B GO:0009987 cellular_process DKK1 GO:0009987 cellular_process COPE GO:0009987 cellular_process CHRDL2 GO:0009987 cellular_process GADD45A GO:0009987 cellular_process ARL4 GO:0009987 cellular_process TAGLN GO:0009987 cellular_process TNNT3 GO:0009987 cellular_process BIRC3 GO:0009987 cellular_process SCAP2 GO:0009987 cellular_process SSBP1 GO:0009987 cellular_process ATP6V1E2 GO:0009987 cellular_process AFP GO:0009987 cellular_process MLF1 GO:0009987 cellular_process MAPK4 GO:0009987 cellular_process WISP2 GO:0009987 cellular_process NAP1L1 GO:0009987 cellular_process NRXN3 GO:0009987 cellular_process APM2 GO:0009987 cellular_process ID2 GO:0009987 cellular_process EPHA3 GO:0009987 cellular_process MAP3K5 GO:0009987 cellular_process CADPS2 GO:0009987 cellular_process SLC2A1 GO:0009987 cellular_process BMP2 GO:0009987 cellular_process GNA11 GO:0009987 cellular_process HDLBP GO:0009987 cellular_process RACGAP1 GO:0009987 cellular_process GNAI1 GO:0009987 cellular_process AR GO:0009987 cellular_process APG3 GO:0009987 cellular_process GPC3 GO:0009987 cellular_process BRS3 GO:0009987 cellular_process TNFRSF1A GO:0009987 cellular_process PRKAR2A GO:0009987 cellular_process GDF3 GO:0009987 cellular_process ELN GO:0009987 cellular_process DSCR1L2 GO:0009987 cellular_process TBPL1 GO:0009987 cellular_process PTGDS

44:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0009987 cellular_process TRAF5 GO:0009987 cellular_process STMN1 GO:0009987 cellular_process COL16A1 GO:0009987 cellular_process GPR45 GO:0009987 cellular_process BAP1 GO:0009987 cellular_process HSPA1A GO:0009987 cellular_process SLCO2A1 GO:0009987 cellular_process LAMB2 GO:0009987 cellular_process BFSP2 GO:0009987 cellular_process SORL1 GO:0009987 cellular_process SPRY1 GO:0009987 cellular_process ADORA2B GO:0009987 cellular_process ACE2 GO:0009987 cellular_process MDK GO:0009987 cellular_process EMP1 GO:0009987 cellular_process SCARB1 GO:0009987 cellular_process NFIA GO:0007417 central_nervous_system_development HESX1 GO:0007417 central_nervous_system_development CKB GO:0007417 central_nervous_system_development EMX2 GO:0007417 central_nervous_system_development DKK1 GO:0007417 central_nervous_system_development POU5F1 GO:0005721 centric_heterochromatin BAZ1B GO:0005814 centriole CETN3 GO:0005813 centrosome CETN3 GO:0005813 centrosome H2AFY GO:0017040 ceramidase_activity GALC GO:0046513 ceramide_biosynthesis PRKAA1 GO:0046514 ceramide_catabolism GALC GO:0006672 ceramide_metabolism GALC GO:0006672 ceramide_metabolism PRKAA1 GO:0015267 channel/pore_class_transporter_activity MID1 GO:0015267 channel/pore_class_transporter_activity FXYD6 GO:0015267 channel/pore_class_transporter_activity GRIN2D GO:0015267 channel/pore_class_transporter_activity CLIC6 GO:0015267 channel/pore_class_transporter_activity CACNA1C GO:0015267 channel/pore_class_transporter_activity SCN9A GO:0015267 channel/pore_class_transporter_activity ROPN1 GO:0003754 chaperone_activity HSPA1A GO:0003754 chaperone_activity AHSA1 GO:0003754 chaperone_activity CKAP1 GO:0003754 chaperone_activity CCT2 GO:0003754 chaperone_activity BAG5 GO:0003754 chaperone_activity CRYAB GO:0005832 chaperonin-containing_T-complex CCT2 GO:0008009 chemokine_activity CX3CL1 GO:0042379 chemokine_receptor_binding CX3CL1 GO:0006935 chemotaxis CX3CL1 GO:0005254 chloride_channel_activity CLIC6 GO:0006821 chloride_transport CLIC6 GO:0009507 chloroplast MAPK4 GO:0009507 chloroplast RPS8 GO:0009507 chloroplast GGPS1 GO:0009658 chloroplast_organization_and_biogenesis APG3 GO:0004951 cholecystokinin_receptor_activity CCKBR GO:0030299 cholesterol_absorption APOA2 GO:0015485 cholesterol_binding STAR GO:0006695 cholesterol_biosynthesis IDI1 GO:0006695 cholesterol_biosynthesis PRKAA1 GO:0008203 cholesterol_metabolism PRKAA1 GO:0008203 cholesterol_metabolism IDI1

45:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008203 cholesterol_metabolism HDLBP GO:0008203 cholesterol_metabolism SORL1 GO:0008203 cholesterol_metabolism APOB GO:0008203 cholesterol_metabolism VLDLR GO:0030301 cholesterol_transport PDZK1 GO:0030301 cholesterol_transport APOB GO:0017127 cholesterol_transporter_activity STAR GO:0004103 choline_kinase_activity EKI1 GO:0004105 choline-phosphate_cytidylyltransferase_activity CCT2 GO:0000785 chromatin DNMT3L GO:0000785 chromatin PARG GO:0000785 chromatin MAPK4 GO:0000785 chromatin HMGB2 GO:0000785 chromatin SOX14 GO:0000785 chromatin H2AFY GO:0000785 chromatin H1F0 GO:0000785 chromatin DNMT3B GO:0000785 chromatin BAZ1B GO:0000785 chromatin PRM2 GO:0006333 chromatin_assembly/disassembly ASF1A GO:0006333 chromatin_assembly/disassembly SIRT7 GO:0006333 chromatin_assembly/disassembly MAPK4 GO:0006333 chromatin_assembly/disassembly HMGB2 GO:0006333 chromatin_assembly/disassembly NAP1L1 GO:0006333 chromatin_assembly/disassembly H2AFY GO:0006333 chromatin_assembly/disassembly H1F0 GO:0006333 chromatin_assembly/disassembly BAZ1B GO:0003682 chromatin_binding SIRT7 GO:0003682 chromatin_binding PARG GO:0003682 chromatin_binding HMGB2 GO:0003682 chromatin_binding H2AFY GO:0016568 chromatin_modification SIRT7 GO:0016568 chromatin_modification BAZ1B GO:0006338 chromatin_remodeling SIRT7 GO:0006338 chromatin_remodeling BAZ1B GO:0016585 chromatin_remodeling_complex ASF1A GO:0016585 chromatin_remodeling_complex SIRT7 GO:0006342 chromatin_silencing SIRT7 GO:0005677 chromatin_silencing_complex SIRT7 GO:0005694 chromosome TERF1 GO:0005694 chromosome SPAG5 GO:0005694 chromosome PARG GO:0005694 chromosome SOX14 GO:0005694 chromosome H2AFY GO:0005694 chromosome H1F0 GO:0005694 chromosome DNMT3B GO:0005694 chromosome PRM2 GO:0005694 chromosome SYCP2 GO:0005694 chromosome DNMT3L GO:0005694 chromosome MAPK4 GO:0005694 chromosome HMGB2 GO:0005694 chromosome BAZ1B GO:0000775 chromosome,_pericentric_region SPAG5 GO:0000781 chromosome,_telomeric_region TERF1 GO:0030261 chromosome_condensation PRM2 GO:0007001 chromosome_organization_and_biogenesis_(sensu_Eukarya) TERF1 GO:0007001 chromosome_organization_and_biogenesis_(sensu_Eukarya) ASF1A GO:0007001 chromosome_organization_and_biogenesis_(sensu_Eukarya) SIRT7 GO:0007001 chromosome_organization_and_biogenesis_(sensu_Eukarya) MAPK4 GO:0007001 chromosome_organization_and_biogenesis_(sensu_Eukarya) HSPA1A GO:0007001 chromosome_organization_and_biogenesis_(sensu_Eukarya) HMGB2

46:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007001 chromosome_organization_and_biogenesis_(sensu_Eukarya) NAP1L1 GO:0007001 chromosome_organization_and_biogenesis_(sensu_Eukarya) H2AFY GO:0007001 chromosome_organization_and_biogenesis_(sensu_Eukarya) H1F0 GO:0007001 chromosome_organization_and_biogenesis_(sensu_Eukarya) BAZ1B GO:0007001 chromosome_organization_and_biogenesis_(sensu_Eukarya) PRM2 GO:0004263 chymotrypsin_activity F2 GO:0004263 chymotrypsin_activity PLAT GO:0004263 chymotrypsin_activity C1R GO:0007623 circadian_rhythm ARNTL GO:0007623 circadian_rhythm BHLHB3 GO:0007623 circadian_rhythm PTGDS GO:0042745 circadian_sleep/wake_cycle PTGDS GO:0050802 circadian_sleep/wake_cycle,_sleep PTGDS GO:0008015 circulation AGTRAP GO:0016859 cis-trans_isomerase_activity CPR8 GO:0016859 cis-trans_isomerase_activity PPIC GO:0030131 clathrin_adaptor_complex AP2B1 GO:0030131 clathrin_adaptor_complex APM2 GO:0030276 clathrin_binding AP2B1 GO:0030276 clathrin_binding APM2 GO:0030118 clathrin_coat AP2B1 GO:0030118 clathrin_coat APM2 GO:0030118 clathrin_coat CLC GO:0030132 clathrin_coat_of_coated_pit AP2B1 GO:0030132 clathrin_coat_of_coated_pit APM2 GO:0030132 clathrin_coat_of_coated_pit CLC GO:0030128 clathrin_coat_of_endocytic_vesicle AP2B1 GO:0030128 clathrin_coat_of_endocytic_vesicle APM2 GO:0030130 clathrin_coat_of_trans-Golgi_network_vesicle APM2 GO:0030125 clathrin_vesicle_coat AP2B1 GO:0030125 clathrin_vesicle_coat APM2 GO:0030125 clathrin_vesicle_coat CLC GO:0045334 clathrin-coated_endocytic_vesicle AP2B1 GO:0045334 clathrin-coated_endocytic_vesicle APM2 GO:0030136 clathrin-coated_vesicle AP2B1 GO:0030136 clathrin-coated_vesicle APM2 GO:0030136 clathrin-coated_vesicle CLC GO:0030136 clathrin-coated_vesicle CADPS2 GO:0050817 coagulation F2 GO:0050817 coagulation FGG GO:0050817 coagulation SERPINC1 GO:0050817 coagulation TM4SF3 GO:0016405 CoA-ligase_activity SUCLA2 GO:0016405 CoA-ligase_activity ACAS2L GO:0005905 coated_pit AP2B1 GO:0005905 coated_pit APM2 GO:0005905 coated_pit LRP10 GO:0005905 coated_pit CLC GO:0005905 coated_pit VLDLR GO:0030135 coated_vesicle AP2B1 GO:0030135 coated_vesicle APM2 GO:0030135 coated_vesicle CLC GO:0030135 coated_vesicle CADPS2 GO:0003767 co-chaperone_activity AHSA1 GO:0046138 coenzyme_and_prosthetic_group_biosynthesis GGTLA1 GO:0046138 coenzyme_and_prosthetic_group_biosynthesis ATP6V1E2 GO:0006731 coenzyme_and_prosthetic_group_metabolism GGTLA1 GO:0006731 coenzyme_and_prosthetic_group_metabolism ACAS2L GO:0006731 coenzyme_and_prosthetic_group_metabolism FOLR1 GO:0006731 coenzyme_and_prosthetic_group_metabolism HEBP1 GO:0006731 coenzyme_and_prosthetic_group_metabolism GSTA1

47:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006731 coenzyme_and_prosthetic_group_metabolism MGST1 GO:0006731 coenzyme_and_prosthetic_group_metabolism ATP6V1E2 GO:0009108 coenzyme_biosynthesis GGTLA1 GO:0009108 coenzyme_biosynthesis ATP6V1E2 GO:0006732 coenzyme_metabolism GGTLA1 GO:0006732 coenzyme_metabolism ACAS2L GO:0006732 coenzyme_metabolism FOLR1 GO:0006732 coenzyme_metabolism GSTA1 GO:0006732 coenzyme_metabolism MGST1 GO:0006732 coenzyme_metabolism ATP6V1E2 GO:0005581 collagen COL6A2 GO:0005581 collagen COL16A1 GO:0005581 collagen COL6A1 GO:0005581 collagen COL4A6 GO:0005581 collagen COL1A2 GO:0005581 collagen COL14A1 GO:0005581 collagen COL5A2 GO:0005581 collagen COL1A1 GO:0005581 collagen COL4A5 GO:0030574 collagen_catabolism MMP11 GO:0005587 collagen_type_IV COL4A6 GO:0005587 collagen_type_IV COL4A5 GO:0005588 collagen_type_V COL5A2 GO:0006956 complement_activation C6 GO:0000793 condensed_chromosome H2AFY GO:0000793 condensed_chromosome BAZ1B GO:0000793 condensed_chromosome SYCP2 GO:0000794 condensed_nuclear_chromosome SYCP2 GO:0000746 conjugation PRM2 GO:0000747 conjugation_with_cellular_fusion PRM2 GO:0005507 copper_ion_binding LOXL1 GO:0005507 copper_ion_binding PRNP GO:0005507 copper_ion_binding MT2A GO:0005507 copper_ion_binding SORL1 GO:0005507 copper_ion_binding PRND GO:0005507 copper_ion_binding MT1A GO:0006878 copper_ion_homeostasis PRNP GO:0006878 copper_ion_homeostasis MT2A GO:0006878 copper_ion_homeostasis PRND GO:0016513 core-binding_factor_complex CBFB GO:0004111 creatine_kinase_activity CKMT2 GO:0004111 creatine_kinase_activity CKB GO:0008420 CTD_phosphatase_activity DUSP6 GO:0008420 CTD_phosphatase_activity PPP6C GO:0030551 cyclic_nucleotide_binding PRKAR2B GO:0030551 cyclic_nucleotide_binding PRKAR2A GO:0004690 cyclic_nucleotide-dependent_protein_kinase_activity PRKAA1 GO:0004690 cyclic_nucleotide-dependent_protein_kinase_activity MAPK4 GO:0019935 cyclic-nucleotide-mediated_signaling PTGER3 GO:0004693 cyclin-dependent_protein_kinase_activity CDK8 GO:0019238 cyclohydrolase_activity ATIC GO:0004122 cystathionine_beta-synthase_activity CBS GO:0019344 cysteine_biosynthesis CBS GO:0006535 cysteine_biosynthesis_from_serine CBS GO:0019343 cysteine_biosynthesis_via_cystathione CBS GO:0006534 cysteine_metabolism CBS GO:0004197 cysteine-type_endopeptidase_activity CAPNS1 GO:0004197 cysteine-type_endopeptidase_activity TENR GO:0004197 cysteine-type_endopeptidase_activity CASP7 GO:0008234 cysteine-type_peptidase_activity CAPNS1 GO:0008234 cysteine-type_peptidase_activity BAP1

48:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008234 cysteine-type_peptidase_activity TENR GO:0008234 cysteine-type_peptidase_activity CASP7 GO:0004128 cytochrome-b5_reductase_activity CBR1 GO:0004129 cytochrome-c_oxidase_activity COX6A2 GO:0004129 cytochrome-c_oxidase_activity COX7C GO:0005125 cytokine_activity BMP2 GO:0005125 cytokine_activity S100A11 GO:0005125 cytokine_activity INHA GO:0005125 cytokine_activity CX3CL1 GO:0005125 cytokine_activity GDF10 GO:0005125 cytokine_activity TNFRSF1A GO:0005125 cytokine_activity GDF3 GO:0019955 cytokine_binding IL27RA GO:0019955 cytokine_binding TNFRSF1A GO:0042089 cytokine_biosynthesis INHA GO:0042089 cytokine_biosynthesis RNF128 GO:0042107 cytokine_metabolism INHA GO:0042107 cytokine_metabolism RNF128 GO:0001816 cytokine_production INHA GO:0001816 cytokine_production RNF128 GO:0000910 cytokinesis SPAG5 GO:0000910 cytokinesis CETN3 GO:0000910 cytokinesis ACE2 GO:0000910 cytokinesis SYCP2 GO:0005737 cytoplasm NARS GO:0005737 cytoplasm H2AFY GO:0005737 cytoplasm TPD52L1 GO:0005737 cytoplasm STAR GO:0005737 cytoplasm GLA GO:0005737 cytoplasm EKI1 GO:0005737 cytoplasm HCCS GO:0005737 cytoplasm SSPN GO:0005737 cytoplasm MTA3 GO:0005737 cytoplasm PGK1 GO:0005737 cytoplasm COX6A2 GO:0005737 cytoplasm ROPN1 GO:0005737 cytoplasm CPR8 GO:0005737 cytoplasm AHR GO:0005737 cytoplasm ARPC1A GO:0005737 cytoplasm PCBD GO:0005737 cytoplasm CKAP1 GO:0005737 cytoplasm MT1A GO:0005737 cytoplasm IDI1 GO:0005737 cytoplasm DNMT3L GO:0005737 cytoplasm ACAS2L GO:0005737 cytoplasm NDUFB9 GO:0005737 cytoplasm DNCL2A GO:0005737 cytoplasm CXXC4 GO:0005737 cytoplasm GK2 GO:0005737 cytoplasm AASS GO:0005737 cytoplasm HEBP1 GO:0005737 cytoplasm PWP1 GO:0005737 cytoplasm PRM2 GO:0005737 cytoplasm PTGES GO:0005737 cytoplasm CAPZA3 GO:0005737 cytoplasm CDC42EP4 GO:0005737 cytoplasm RPS8 GO:0005737 cytoplasm MYOZ2 GO:0005737 cytoplasm GGPS1 GO:0005737 cytoplasm HSD3B1 GO:0005737 cytoplasm MYH11

49:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005737 cytoplasm YBX2 GO:0005737 cytoplasm RNF128 GO:0005737 cytoplasm CRYAB GO:0005737 cytoplasm FEN1 GO:0005737 cytoplasm MSN GO:0005737 cytoplasm CBS GO:0005737 cytoplasm SPAG5 GO:0005737 cytoplasm DUSP6 GO:0005737 cytoplasm CALB1 GO:0005737 cytoplasm RPL18A GO:0005737 cytoplasm CYP26A1 GO:0005737 cytoplasm RPL28 GO:0005737 cytoplasm STX6 GO:0005737 cytoplasm SIAT4C GO:0005737 cytoplasm RRAS2 GO:0005737 cytoplasm SYCP2 GO:0005737 cytoplasm MID1 GO:0005737 cytoplasm ELOVL4 GO:0005737 cytoplasm HSD3B2 GO:0005737 cytoplasm CKB GO:0005737 cytoplasm MGST1 GO:0005737 cytoplasm EPPK1 GO:0005737 cytoplasm RPL29 GO:0005737 cytoplasm MGAT5 GO:0005737 cytoplasm AP2B1 GO:0005737 cytoplasm GLB1 GO:0005737 cytoplasm PTPN13 GO:0005737 cytoplasm CAPZB GO:0005737 cytoplasm CUL1 GO:0005737 cytoplasm CETN3 GO:0005737 cytoplasm PRNP GO:0005737 cytoplasm CCT2 GO:0005737 cytoplasm APOB GO:0005737 cytoplasm CLC GO:0005737 cytoplasm GFPT2 GO:0005737 cytoplasm CYP17A1 GO:0005737 cytoplasm GALC GO:0005737 cytoplasm COPE GO:0005737 cytoplasm GADD45A GO:0005737 cytoplasm TNNT3 GO:0005737 cytoplasm COX7C GO:0005737 cytoplasm SCAP2 GO:0005737 cytoplasm SSBP1 GO:0005737 cytoplasm ATP6V1E2 GO:0005737 cytoplasm TMLHE GO:0005737 cytoplasm TAPBP GO:0005737 cytoplasm MAPK4 GO:0005737 cytoplasm WISP2 GO:0005737 cytoplasm APM2 GO:0005737 cytoplasm CADPS2 GO:0005737 cytoplasm SUCLA2 GO:0005737 cytoplasm CKMT2 GO:0005737 cytoplasm LIN28 GO:0005737 cytoplasm CBR3 GO:0005737 cytoplasm AR GO:0005737 cytoplasm TK1 GO:0005737 cytoplasm TBPL1 GO:0005737 cytoplasm PTGDS GO:0005737 cytoplasm STMN1 GO:0005737 cytoplasm LAMB2 GO:0005737 cytoplasm ACE2

50:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007028 cytoplasm_organization_and_biogenesis RPL29 GO:0007028 cytoplasm_organization_and_biogenesis MYH11 GO:0007028 cytoplasm_organization_and_biogenesis ARPC1A GO:0007028 cytoplasm_organization_and_biogenesis RPL28 GO:0007028 cytoplasm_organization_and_biogenesis APG3 GO:0007028 cytoplasm_organization_and_biogenesis CKAP1 GO:0007028 cytoplasm_organization_and_biogenesis TAGLN GO:0007028 cytoplasm_organization_and_biogenesis PLS3 GO:0007028 cytoplasm_organization_and_biogenesis PRH1 GO:0007028 cytoplasm_organization_and_biogenesis CAPZB GO:0007028 cytoplasm_organization_and_biogenesis ELN GO:0007028 cytoplasm_organization_and_biogenesis CAPZA3 GO:0007028 cytoplasm_organization_and_biogenesis STMN1 GO:0007028 cytoplasm_organization_and_biogenesis FN1 GO:0007028 cytoplasm_organization_and_biogenesis RPS8 GO:0007028 cytoplasm_organization_and_biogenesis MSN GO:0007028 cytoplasm_organization_and_biogenesis BFSP2 GO:0007028 cytoplasm_organization_and_biogenesis DNCL2A GO:0007028 cytoplasm_organization_and_biogenesis CCT2 GO:0007028 cytoplasm_organization_and_biogenesis MPZ GO:0000153 cytoplasmic_ubiquitin_ligase_complex CUL1 GO:0016023 cytoplasmic_vesicle CXXC4 GO:0016023 cytoplasmic_vesicle AP2B1 GO:0016023 cytoplasmic_vesicle APM2 GO:0016023 cytoplasmic_vesicle CLC GO:0016023 cytoplasmic_vesicle CADPS2 GO:0008092 cytoskeletal_protein_binding MYH11 GO:0008092 cytoskeletal_protein_binding CAPZA3 GO:0008092 cytoskeletal_protein_binding SPAG5 GO:0008092 cytoskeletal_protein_binding STMN1 GO:0008092 cytoskeletal_protein_binding ARPC1A GO:0008092 cytoskeletal_protein_binding PLS3 GO:0008092 cytoskeletal_protein_binding CAPZB GO:0005856 cytoskeleton MYH11 GO:0005856 cytoskeleton SPAG5 GO:0005856 cytoskeleton ARPC1A GO:0005856 cytoskeleton H2AFY GO:0005856 cytoskeleton STX6 GO:0005856 cytoskeleton CKAP1 GO:0005856 cytoskeleton TNNT3 GO:0005856 cytoskeleton PTPN13 GO:0005856 cytoskeleton CAPZB GO:0005856 cytoskeleton SYCP2 GO:0005856 cytoskeleton CAPZA3 GO:0005856 cytoskeleton SSPN GO:0005856 cytoskeleton STMN1 GO:0005856 cytoskeleton CDC42EP4 GO:0005856 cytoskeleton MID1 GO:0005856 cytoskeleton CETN3 GO:0005856 cytoskeleton MSN GO:0005856 cytoskeleton LAMB2 GO:0005856 cytoskeleton DNCL2A GO:0005856 cytoskeleton MYOZ2 GO:0005856 cytoskeleton CCT2 GO:0005856 cytoskeleton EPPK1 GO:0007010 cytoskeleton_organization_and_biogenesis MYH11 GO:0007010 cytoskeleton_organization_and_biogenesis ARPC1A GO:0007010 cytoskeleton_organization_and_biogenesis CKAP1 GO:0007010 cytoskeleton_organization_and_biogenesis TAGLN GO:0007010 cytoskeleton_organization_and_biogenesis PLS3 GO:0007010 cytoskeleton_organization_and_biogenesis CAPZB

51:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007010 cytoskeleton_organization_and_biogenesis ELN GO:0007010 cytoskeleton_organization_and_biogenesis CAPZA3 GO:0007010 cytoskeleton_organization_and_biogenesis STMN1 GO:0007010 cytoskeleton_organization_and_biogenesis MSN GO:0007010 cytoskeleton_organization_and_biogenesis BFSP2 GO:0007010 cytoskeleton_organization_and_biogenesis DNCL2A GO:0007010 cytoskeleton_organization_and_biogenesis CCT2 GO:0030705 cytoskeleton-dependent_intracellular_transport DNCL2A GO:0005829 cytosol RPL29 GO:0005829 cytosol IDI1 GO:0005829 cytosol PGK1 GO:0005829 cytosol HEBP1 GO:0005829 cytosol RPL18A GO:0005829 cytosol RPS8 GO:0005829 cytosol RPL28 GO:0005829 cytosol CBR3 GO:0005829 cytosol ACE2 GO:0005829 cytosol CCT2 GO:0005829 cytosol MT1A GO:0007204 cytosolic_calcium_ion_concentration_elevation PTGER3 GO:0007204 cytosolic_calcium_ion_concentration_elevation GPR6 GO:0005842 cytosolic_large_ribosomal_subunit_(sensu_Eukarya) RPL29 GO:0005842 cytosolic_large_ribosomal_subunit_(sensu_Eukarya) RPL18A GO:0005842 cytosolic_large_ribosomal_subunit_(sensu_Eukarya) RPL28 GO:0005830 cytosolic_ribosome_(sensu_Eukarya) RPL29 GO:0005830 cytosolic_ribosome_(sensu_Eukarya) RPL18A GO:0005830 cytosolic_ribosome_(sensu_Eukarya) RPS8 GO:0005830 cytosolic_ribosome_(sensu_Eukarya) RPL28 GO:0005843 cytosolic_small_ribosomal_subunit_(sensu_Eukarya) RPL18A GO:0005843 cytosolic_small_ribosomal_subunit_(sensu_Eukarya) RPS8 GO:0006189 'de_novo'_IMP_biosynthesis PAICS GO:0019213 deacetylase_activity SIRT7 GO:0019239 deaminase_activity TENR GO:0019239 deaminase_activity AMPD2 GO:0016265 death PRKAA1 GO:0016265 death AHR GO:0016265 death INHA GO:0016265 death CUL1 GO:0016265 death TNFRSF1A GO:0016265 death BIRC3 GO:0016265 death CASP7 GO:0016265 death MAP3K5 GO:0016265 death APPBP1 GO:0016265 death IGF1 GO:0016265 death TRAF5 GO:0005035 death_receptor_activity TNFRSF1A GO:0006952 defense_response INHA GO:0006952 defense_response TCEA2 GO:0006952 defense_response RNF128 GO:0006952 defense_response PTGER3 GO:0006952 defense_response C6 GO:0006952 defense_response TNFRSF1A GO:0006952 defense_response GAL GO:0006952 defense_response INDO GO:0006952 defense_response F2 GO:0006952 defense_response GGTLA1 GO:0006952 defense_response TAPBP GO:0006952 defense_response CBFB GO:0006952 defense_response FN1 GO:0006952 defense_response HSPA1A GO:0006952 defense_response LY6E

52:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006952 defense_response IL27RA GO:0006952 defense_response ENPEP GO:0006952 defense_response TLR8 GO:0006952 defense_response FGG GO:0006952 defense_response CX3CL1 GO:0006952 defense_response PAP GO:0006952 defense_response LST1 GO:0016358 dendrite_morphogenesis MCF2 GO:0019136 deoxynucleoside_kinase_activity TK1 GO:0004536 deoxyribonuclease_activity FEN1 GO:0009120 deoxyribonucleoside_metabolism TBPL1 GO:0009202 deoxyribonucleoside_triphosphate_biosynthesis TBPL1 GO:0009204 deoxyribonucleoside_triphosphate_catabolism NUDT1 GO:0009200 deoxyribonucleoside_triphosphate_metabolism NUDT1 GO:0009200 deoxyribonucleoside_triphosphate_metabolism TBPL1 GO:0009263 deoxyribonucleotide_biosynthesis TBPL1 GO:0009264 deoxyribonucleotide_catabolism NUDT1 GO:0009262 deoxyribonucleotide_metabolism NUDT1 GO:0009262 deoxyribonucleotide_metabolism TBPL1 GO:0016311 dephosphorylation DUSP6 GO:0016311 dephosphorylation PTPRK GO:0016311 dephosphorylation PPP6C GO:0016311 dephosphorylation PTPN13 GO:0016311 dephosphorylation PTPRR GO:0009582 detection_of_abiotic_stimulus NDUFB9 GO:0009582 detection_of_abiotic_stimulus PDCL3 GO:0009581 detection_of_external_stimulus NDUFB9 GO:0009581 detection_of_external_stimulus PDCL3 GO:0009581 detection_of_external_stimulus NR2F1 GO:0009583 detection_of_light PDCL3 GO:0050982 detection_of_mechanical_stimulus NDUFB9 GO:0007275 development GPC4 GO:0007275 development DUSP6 GO:0007275 development INHA GO:0007275 development PRKAR2B GO:0007275 development DSCAM GO:0007275 development EPAS1 GO:0007275 development JARID2 GO:0007275 development TBX3 GO:0007275 development GAL GO:0007275 development CKB GO:0007275 development PAX5 GO:0007275 development SALL1 GO:0007275 development TNA GO:0007275 development POU5F1 GO:0007275 development LST1 GO:0007275 development FZD7 GO:0007275 development ARPC1A GO:0007275 development BAMBI GO:0007275 development PAX3 GO:0007275 development AES GO:0007275 development FZD4 GO:0007275 development DDX20 GO:0007275 development SEMA5B GO:0007275 development NR2F1 GO:0007275 development SIRT7 GO:0007275 development DNMT3L GO:0007275 development TBX2 GO:0007275 development CUL1 GO:0007275 development SHOX2 GO:0007275 development BHLHB3

53:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007275 development EMX2 GO:0007275 development PMP22 GO:0007275 development COL1A1 GO:0007275 development DKK1 GO:0007275 development SEMA4C GO:0007275 development HEBP1 GO:0007275 development CHRDL2 GO:0007275 development SOX14 GO:0007275 development SEMA3E GO:0007275 development TNNT3 GO:0007275 development TAGLN GO:0007275 development TLX2 GO:0007275 development DNMT3B GO:0007275 development PRM2 GO:0007275 development AFP GO:0007275 development MLF1 GO:0007275 development CDC42EP4 GO:0007275 development CBFB GO:0007275 development HMGB2 GO:0007275 development WISP2 GO:0007275 development HESX1 GO:0007275 development PPP6C GO:0007275 development ID2 GO:0007275 development GDF10 GO:0007275 development EPHA3 GO:0007275 development MYH11 GO:0007275 development GNA11 GO:0007275 development BMP2 GO:0007275 development ANXA4 GO:0007275 development AR GO:0007275 development GPC3 GO:0007275 development TNFRSF1A GO:0007275 development MCF2 GO:0007275 development GMPR2 GO:0007275 development ELN GO:0007275 development SEMA6A GO:0007275 development TBPL1 GO:0007275 development GDF3 GO:0007275 development CRYAB GO:0007275 development INSL3 GO:0007275 development STMN1 GO:0007275 development MSN GO:0007275 development SORL1 GO:0007275 development SPRY1 GO:0007275 development ADORA2B GO:0007275 development MDK GO:0007275 development EMP1 GO:0007275 development ROR1 GO:0007275 development FBLN1 GO:0007275 development IGF1 GO:0006203 dGTP_catabolism NUDT1 GO:0046070 dGTP_metabolism NUDT1 GO:0030005 di-,_tri-valent_inorganic_cation_homeostasis PRNP GO:0030005 di-,_tri-valent_inorganic_cation_homeostasis MT2A GO:0030005 di-,_tri-valent_inorganic_cation_homeostasis MT1A GO:0030005 di-,_tri-valent_inorganic_cation_homeostasis PRND GO:0015674 di-,_tri-valent_inorganic_cation_transport MID1 GO:0015674 di-,_tri-valent_inorganic_cation_transport CACNA1C GO:0007586 digestion APOA2 GO:0015270 dihydropyridine-sensitive_calcium_channel_activity CACNA1C GO:0008239 dipeptidyl-peptidase_activity FAP

54:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0016806 dipeptidyl-peptidase_and_tripeptidyl-peptidase_activity FAP GO:0004274 dipeptidyl-peptidase_IV_activity FAP GO:0008486 diphosphoinositol-polyphosphate_diphosphatase_activity NUDT10 GO:0008486 diphosphoinositol-polyphosphate_diphosphatase_activity NUDT11 GO:0030146 diuresis PTGER3 GO:0006305 DNA_alkylation DNMT3B GO:0008301 DNA_bending_activity SOX14 GO:0003677 DNA_binding EPAS1 GO:0003677 DNA_binding H2AFY GO:0003677 DNA_binding JARID2 GO:0003677 DNA_binding TBX3 GO:0003677 DNA_binding SOX30 GO:0003677 DNA_binding SYCP2 GO:0003677 DNA_binding MTA3 GO:0003677 DNA_binding TRPS1 GO:0003677 DNA_binding LYAR GO:0003677 DNA_binding PAX5 GO:0003677 DNA_binding SALL1 GO:0003677 DNA_binding POU5F1 GO:0003677 DNA_binding AHR GO:0003677 DNA_binding PPP1R12B GO:0003677 DNA_binding PARG GO:0003677 DNA_binding ZFP36L2 GO:0003677 DNA_binding CEBPD GO:0003677 DNA_binding PAX3 GO:0003677 DNA_binding DDX20 GO:0003677 DNA_binding TCF7L2 GO:0003677 DNA_binding H1F0 GO:0003677 DNA_binding NR2F1 GO:0003677 DNA_binding FEM1B GO:0003677 DNA_binding HEY1 GO:0003677 DNA_binding SIRT7 GO:0003677 DNA_binding TBX2 GO:0003677 DNA_binding SHOX2 GO:0003677 DNA_binding BHLHB3 GO:0003677 DNA_binding EMX2 GO:0003677 DNA_binding ATBF1 GO:0003677 DNA_binding BAZ1B GO:0003677 DNA_binding TCEA2 GO:0003677 DNA_binding SOX14 GO:0003677 DNA_binding KLF12 GO:0003677 DNA_binding TLX2 GO:0003677 DNA_binding MLL GO:0003677 DNA_binding DNMT3B GO:0003677 DNA_binding PRM2 GO:0003677 DNA_binding SSBP1 GO:0003677 DNA_binding APEH GO:0003677 DNA_binding ETS2 GO:0003677 DNA_binding CBFB GO:0003677 DNA_binding MAPK4 GO:0003677 DNA_binding HMGB2 GO:0003677 DNA_binding NAP1L1 GO:0003677 DNA_binding HESX1 GO:0003677 DNA_binding NANOG GO:0003677 DNA_binding ARID3A GO:0003677 DNA_binding NSEP1 GO:0003677 DNA_binding TERF1 GO:0003677 DNA_binding ARNTL GO:0003677 DNA_binding HNF3B GO:0003677 DNA_binding AR GO:0003677 DNA_binding ZFP36L1

55:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0003677 DNA_binding FOXA1 GO:0003677 DNA_binding FEN1 GO:0003677 DNA_binding TCF8 GO:0003677 DNA_binding NFIA GO:0006259 DNA_metabolism ASF1A GO:0006259 DNA_metabolism H2AFY GO:0006259 DNA_metabolism TK1 GO:0006259 DNA_metabolism H1F0 GO:0006259 DNA_metabolism DNMT3B GO:0006259 DNA_metabolism MLL GO:0006259 DNA_metabolism SSBP1 GO:0006259 DNA_metabolism SIRT7 GO:0006259 DNA_metabolism MAPK4 GO:0006259 DNA_metabolism HSPA1A GO:0006259 DNA_metabolism HMGB2 GO:0006259 DNA_metabolism FEN1 GO:0006259 DNA_metabolism NAP1L1 GO:0006259 DNA_metabolism NFIA GO:0006259 DNA_metabolism BAZ1B GO:0006306 DNA_methylation DNMT3B GO:0006304 DNA_modification DNMT3B GO:0006323 DNA_packaging ASF1A GO:0006323 DNA_packaging SIRT7 GO:0006323 DNA_packaging MAPK4 GO:0006323 DNA_packaging HMGB2 GO:0006323 DNA_packaging NAP1L1 GO:0006323 DNA_packaging H2AFY GO:0006323 DNA_packaging H1F0 GO:0006323 DNA_packaging BAZ1B GO:0006310 DNA_recombination MLL GO:0006281 DNA_repair ASF1A GO:0006281 DNA_repair HSPA1A GO:0006281 DNA_repair FEN1 GO:0006281 DNA_repair MLL GO:0006260 DNA_replication FEN1 GO:0006260 DNA_replication NFIA GO:0006260 DNA_replication SSBP1 GO:0000067 DNA_replication_and_chromosome_cycle FEN1 GO:0000067 DNA_replication_and_chromosome_cycle NFIA GO:0000067 DNA_replication_and_chromosome_cycle SSBP1 GO:0000067 DNA_replication_and_chromosome_cycle PRM2 GO:0016591 DNA-directed_RNA_polymerase_II,_holoenzyme CDK8 GO:0009953 dorsal/ventral_pattern_formation BAMBI GO:0007391 dorsal_closure MSN GO:0003690 double-stranded_DNA_binding HMGB2 GO:0003690 double-stranded_DNA_binding TCF8 GO:0003725 double-stranded_RNA_binding TENR GO:0006235 dTTP_biosynthesis TBPL1 GO:0046075 dTTP_metabolism TBPL1 GO:0030286 dynein_complex DNCL2A GO:0005769 early_endosome TPD52L1 GO:0007398 ectoderm_development DSCAM GO:0007398 ectoderm_development SOX14 GO:0007398 ectoderm_development DKK1 GO:0007398 ectoderm_development POU5F1 GO:0048251 elastic_fiber_assembly ELN GO:0015290 electrochemical_potential-driven_transporter_activity SLC19A2 GO:0015290 electrochemical_potential-driven_transporter_activity SLC2A1 GO:0015290 electrochemical_potential-driven_transporter_activity CDH17 GO:0015290 electrochemical_potential-driven_transporter_activity SLC17A1 GO:0015290 electrochemical_potential-driven_transporter_activity SLC7A11

56:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0015290 electrochemical_potential-driven_transporter_activity SLC2A3 GO:0015290 electrochemical_potential-driven_transporter_activity SLC19A1 GO:0015290 electrochemical_potential-driven_transporter_activity TBPL1 GO:0006118 electron_transport CYP17A1 GO:0006118 electron_transport NQO1 GO:0006118 electron_transport AASS GO:0006118 electron_transport CYP26A1 GO:0006118 electron_transport COX7C GO:0006118 electron_transport MLL GO:0006118 electron_transport NDUFB9 GO:0006118 electron_transport GLRX2 GO:0006118 electron_transport LAMB2 GO:0006118 electron_transport COX6A2 GO:0006118 electron_transport CBR1 GO:0006118 electron_transport SORL1 GO:0006118 electron_transport CYP19A1 GO:0005489 electron_transporter_activity LOXL1 GO:0005489 electron_transporter_activity NDUFB9 GO:0005489 electron_transporter_activity CBR1 GO:0005489 electron_transporter_activity SORL1 GO:0005489 electron_transporter_activity MLL GO:0009790 embryonic_development DNMT3L GO:0009790 embryonic_development BMP2 GO:0009790 embryonic_development MSN GO:0009790 embryonic_development AR GO:0009790 embryonic_development GPC3 GO:0009790 embryonic_development EPHA3 GO:0009790 embryonic_development DKK1 GO:0009790 embryonic_development INSL3 GO:0009790 embryonic_development POU5F1 GO:0009792 embryonic_development_(sensu_Animalia) DNMT3L GO:0009792 embryonic_development_(sensu_Animalia) MSN GO:0009792 embryonic_development_(sensu_Animalia) AR GO:0009792 embryonic_development_(sensu_Animalia) GPC3 GO:0009792 embryonic_development_(sensu_Animalia) EPHA3 GO:0009792 embryonic_development_(sensu_Animalia) POU5F1 GO:0009792 embryonic_development_(sensu_Animalia) INSL3 GO:0001700 embryonic_development_(sensu_Insecta) MSN GO:0001701 embryonic_development_(sensu_Mammalia) DNMT3L GO:0001701 embryonic_development_(sensu_Mammalia) AR GO:0001701 embryonic_development_(sensu_Mammalia) INSL3 GO:0043009 embryonic_development_(sensu_Vertebrata) DNMT3L GO:0043009 embryonic_development_(sensu_Vertebrata) AR GO:0043009 embryonic_development_(sensu_Vertebrata) EPHA3 GO:0043009 embryonic_development_(sensu_Vertebrata) INSL3 GO:0009795 embryonic_morphogenesis MSN GO:0009795 embryonic_morphogenesis DKK1 GO:0009795 embryonic_morphogenesis POU5F1 GO:0009880 embryonic_pattern_specification POU5F1 GO:0030139 endocytic_vesicle AP2B1 GO:0030139 endocytic_vesicle APM2 GO:0006897 endocytosis LRRN3 GO:0006897 endocytosis SORL1 GO:0006897 endocytosis LRP10 GO:0006897 endocytosis CLC GO:0006897 endocytosis VLDLR GO:0004520 endodeoxyribonuclease_activity FEN1 GO:0007492 endoderm_development POU5F1 GO:0001706 endoderm_formation POU5F1 GO:0012505 endomembrane_system FEN1 GO:0012505 endomembrane_system NRBP

57:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0012505 endomembrane_system PTGDS GO:0004519 endonuclease_activity FEN1 GO:0004175 endopeptidase_activity F2 GO:0004175 endopeptidase_activity MMP11 GO:0004175 endopeptidase_activity CAPNS1 GO:0004175 endopeptidase_activity COL6A1 GO:0004175 endopeptidase_activity PLAT GO:0004175 endopeptidase_activity TENR GO:0004175 endopeptidase_activity C1R GO:0004175 endopeptidase_activity ADAMTS19 GO:0004175 endopeptidase_activity ZMPSTE24 GO:0004175 endopeptidase_activity FAP GO:0004175 endopeptidase_activity CASP7 GO:0004175 endopeptidase_activity APEH GO:0004866 endopeptidase_inhibitor_activity AMBP GO:0004866 endopeptidase_inhibitor_activity TIMP4 GO:0004866 endopeptidase_inhibitor_activity SERPINC1 GO:0004866 endopeptidase_inhibitor_activity PAPLN GO:0005783 endoplasmic_reticulum TAPBP GO:0005783 endoplasmic_reticulum ELOVL4 GO:0005783 endoplasmic_reticulum PRNP GO:0005783 endoplasmic_reticulum HSD3B2 GO:0005783 endoplasmic_reticulum FEN1 GO:0005783 endoplasmic_reticulum CYP26A1 GO:0005783 endoplasmic_reticulum RNF128 GO:0005783 endoplasmic_reticulum APOB GO:0005783 endoplasmic_reticulum RRAS2 GO:0005783 endoplasmic_reticulum HSD3B1 GO:0005783 endoplasmic_reticulum PTGDS GO:0005789 endoplasmic_reticulum_membrane FEN1 GO:0005768 endosome RNF128 GO:0005768 endosome TPD52L1 GO:0015988 energy_coupled_proton_transport,_against_electrochemical_gradient ATP6V1E2 GO:0015985 energy_coupled_proton_transport,_down_electrochemical_gradient ATP6V1E2 GO:0015980 energy_derivation_by_oxidation_of_organic_compounds SUCLA2 GO:0015980 energy_derivation_by_oxidation_of_organic_compounds LDHA GO:0015980 energy_derivation_by_oxidation_of_organic_compounds PRKAA1 GO:0015980 energy_derivation_by_oxidation_of_organic_compounds PGK1 GO:0015980 energy_derivation_by_oxidation_of_organic_compounds PARG GO:0006091 energy_pathways LDHA GO:0006091 energy_pathways SUCLA2 GO:0006091 energy_pathways PRKAA1 GO:0006091 energy_pathways PARG GO:0006091 energy_pathways PGK1 GO:0009649 entrainment_of_circadian_clock BHLHB3 GO:0008047 enzyme_activator_activity PRKAA1 GO:0008047 enzyme_activator_activity TBC1D1 GO:0008047 enzyme_activator_activity AHSA1 GO:0019899 enzyme_binding GNB2L1 GO:0019899 enzyme_binding PTPRR GO:0004857 enzyme_inhibitor_activity AMBP GO:0004857 enzyme_inhibitor_activity TIMP4 GO:0004857 enzyme_inhibitor_activity ANXA3 GO:0004857 enzyme_inhibitor_activity SERPINC1 GO:0004857 enzyme_inhibitor_activity PAPLN GO:0007167 enzyme_linked_receptor_protein_signaling_pathway PTPRD GO:0007167 enzyme_linked_receptor_protein_signaling_pathway BMP2 GO:0007167 enzyme_linked_receptor_protein_signaling_pathway BAMBI GO:0007167 enzyme_linked_receptor_protein_signaling_pathway CHRDL2 GO:0007167 enzyme_linked_receptor_protein_signaling_pathway PTPRK GO:0007167 enzyme_linked_receptor_protein_signaling_pathway ANGPTL1

58:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007167 enzyme_linked_receptor_protein_signaling_pathway EPHA3 GO:0007167 enzyme_linked_receptor_protein_signaling_pathway PTPRR GO:0007167 enzyme_linked_receptor_protein_signaling_pathway IGF1 GO:0030234 enzyme_regulator_activity SPA17 GO:0030234 enzyme_regulator_activity AMBP GO:0030234 enzyme_regulator_activity PRKAA1 GO:0030234 enzyme_regulator_activity PRKAR2B GO:0030234 enzyme_regulator_activity TIMP4 GO:0030234 enzyme_regulator_activity TBC1D1 GO:0030234 enzyme_regulator_activity AHSA1 GO:0030234 enzyme_regulator_activity ANXA3 GO:0030234 enzyme_regulator_activity PRKAR2A GO:0030234 enzyme_regulator_activity MCF2 GO:0030234 enzyme_regulator_activity SERPINC1 GO:0030234 enzyme_regulator_activity PAPLN GO:0005003 ephrin_receptor_activity EPHA3 GO:0050957 equilibrioception NR2F1 GO:0006696 ergosterol_biosynthesis IDI1 GO:0008204 ergosterol_metabolism IDI1 GO:0030218 erythrocyte_differentiation INHA GO:0006325 establishment_and/or_maintenance_of_chromatin_architecture ASF1A GO:0006325 establishment_and/or_maintenance_of_chromatin_architecture SIRT7 GO:0006325 establishment_and/or_maintenance_of_chromatin_architecture MAPK4 GO:0006325 establishment_and/or_maintenance_of_chromatin_architecture HMGB2 GO:0006325 establishment_and/or_maintenance_of_chromatin_architecture NAP1L1 GO:0006325 establishment_and/or_maintenance_of_chromatin_architecture H2AFY GO:0006325 establishment_and/or_maintenance_of_chromatin_architecture H1F0 GO:0006325 establishment_and/or_maintenance_of_chromatin_architecture BAZ1B GO:0001736 establishment_of_planar_polarity MSN GO:0007164 establishment_of_tissue_polarity MSN GO:0004303 estradiol_17-beta-dehydrogenase_activity HSD17B1 GO:0006703 estrogen_biosynthesis HSD17B1 GO:0008210 estrogen_metabolism HSD17B1 GO:0004304 estrone_sulfotransferase_activity SULT1E1 GO:0042439 ethanolamine_and_derivative_metabolism EKI1 GO:0046335 ethanolamine_biosynthesis EKI1 GO:0004305 ethanolamine_kinase_activity EKI1 GO:0006580 ethanolamine_metabolism EKI1 GO:0016282 eukaryotic_43S_preinitiation_complex RPL18A GO:0016282 eukaryotic_43S_preinitiation_complex RPS8 GO:0016283 eukaryotic_48S_initiation_complex RPL18A GO:0016283 eukaryotic_48S_initiation_complex RPS8 GO:0042557 eukaryotic_elongation_factor-2_kinase_activator_activity PRKAA1 GO:0042556 eukaryotic_elongation_factor-2_kinase_regulator_activity PRKAA1 GO:0005231 excitatory_extracellular_ligand-gated_ion_channel_activity GRIN2D GO:0006887 exocytosis ANXA4 GO:0006887 exocytosis CADPS2 GO:0004529 exodeoxyribonuclease_activity FEN1 GO:0042607 exogenous_peptide_antigen_binding IL27RA GO:0004527 exonuclease_activity FEN1 GO:0008238 exopeptidase_activity ENPEP GO:0008238 exopeptidase_activity ACE2 GO:0008238 exopeptidase_activity RNPEP GO:0008238 exopeptidase_activity FAP GO:0009897 external_side_of_plasma_membrane MS4A2 GO:0005576 extracellular INHA GO:0005576 extracellular DSCAM GO:0005576 extracellular GLA GO:0005576 extracellular CRH GO:0005576 extracellular FOLR1 GO:0005576 extracellular COX6A2

59:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005576 extracellular SLC2A3 GO:0005576 extracellular FZD7 GO:0005576 extracellular NUDT1 GO:0005576 extracellular PLAT GO:0005576 extracellular TBL2 GO:0005576 extracellular PTPRK GO:0005576 extracellular ANGPTL1 GO:0005576 extracellular CDH16 GO:0005576 extracellular PTPRR GO:0005576 extracellular VLDLR GO:0005576 extracellular ART3 GO:0005576 extracellular CART GO:0005576 extracellular TIMP4 GO:0005576 extracellular APOE GO:0005576 extracellular CX3CL1 GO:0005576 extracellular PMP22 GO:0005576 extracellular SERPINC1 GO:0005576 extracellular COL4A5 GO:0005576 extracellular COL6A2 GO:0005576 extracellular VTN GO:0005576 extracellular THBS2 GO:0005576 extracellular SEMA3E GO:0005576 extracellular COL5A2 GO:0005576 extracellular PTGES GO:0005576 extracellular FXYD6 GO:0005576 extracellular COL6A1 GO:0005576 extracellular CDH17 GO:0005576 extracellular PPIC GO:0005576 extracellular ADAMTS19 GO:0005576 extracellular MPZ GO:0005576 extracellular GDF10 GO:0005576 extracellular APOA2 GO:0005576 extracellular PAP GO:0005576 extracellular TGFBI GO:0005576 extracellular COL4A6 GO:0005576 extracellular COL1A2 GO:0005576 extracellular RNF128 GO:0005576 extracellular F2 GO:0005576 extracellular AMBP GO:0005576 extracellular LOXL1 GO:0005576 extracellular FN1 GO:0005576 extracellular CGA GO:0005576 extracellular LRP10 GO:0005576 extracellular COL14A1 GO:0005576 extracellular ROR1 GO:0005576 extracellular IGF1 GO:0005576 extracellular GPC4 GO:0005576 extracellular EGFL6 GO:0005576 extracellular CYP26A1 GO:0005576 extracellular SIAT4C GO:0005576 extracellular GAL GO:0005576 extracellular LRRN3 GO:0005576 extracellular ALPI GO:0005576 extracellular IL27RA GO:0005576 extracellular CRISP2 GO:0005576 extracellular TLR8 GO:0005576 extracellular LRIG1 GO:0005576 extracellular CYP19A1 GO:0005576 extracellular MFAP4 GO:0005576 extracellular TNA GO:0005576 extracellular GLB1

60:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005576 extracellular GRIN2D GO:0005576 extracellular FZD4 GO:0005576 extracellular IFNGR2 GO:0005576 extracellular GLIPR1 GO:0005576 extracellular C6 GO:0005576 extracellular SEMA5B GO:0005576 extracellular TTR GO:0005576 extracellular C1R GO:0005576 extracellular COL1A1 GO:0005576 extracellular DKK1 GO:0005576 extracellular CYP17A1 GO:0005576 extracellular SEMA4C GO:0005576 extracellular MMP11 GO:0005576 extracellular CHRDL2 GO:0005576 extracellular HS2ST1 GO:0005576 extracellular AFP GO:0005576 extracellular JAM2 GO:0005576 extracellular TPST2 GO:0005576 extracellular WISP2 GO:0005576 extracellular LY6E GO:0005576 extracellular FGG GO:0005576 extracellular EPHA3 GO:0005576 extracellular CADPS2 GO:0005576 extracellular BMP2 GO:0005576 extracellular GPC3 GO:0005576 extracellular OGN GO:0005576 extracellular TNFRSF1A GO:0005576 extracellular ELN GO:0005576 extracellular GDF3 GO:0005576 extracellular INSL3 GO:0005576 extracellular PTGDS GO:0005576 extracellular COL16A1 GO:0005576 extracellular LAMB2 GO:0005576 extracellular SORL1 GO:0005576 extracellular ADORA2B GO:0005576 extracellular ACE2 GO:0005576 extracellular MDK GO:0005576 extracellular EMP1 GO:0005576 extracellular FBLN1 GO:0005230 extracellular_ligand-gated_ion_channel_activity GRIN2D GO:0005578 extracellular_matrix COL6A2 GO:0005578 extracellular_matrix MMP11 GO:0005578 extracellular_matrix GPC4 GO:0005578 extracellular_matrix TGFBI GO:0005578 extracellular_matrix COL4A6 GO:0005578 extracellular_matrix COL1A2 GO:0005578 extracellular_matrix GPC3 GO:0005578 extracellular_matrix COL5A2 GO:0005578 extracellular_matrix ELN GO:0005578 extracellular_matrix COL16A1 GO:0005578 extracellular_matrix COL6A1 GO:0005578 extracellular_matrix FN1 GO:0005578 extracellular_matrix TIMP4 GO:0005578 extracellular_matrix LAMB2 GO:0005578 extracellular_matrix ADAMTS19 GO:0005578 extracellular_matrix COL14A1 GO:0005578 extracellular_matrix COL1A1 GO:0005578 extracellular_matrix MFAP4 GO:0005578 extracellular_matrix TNA GO:0005578 extracellular_matrix FBLN1 GO:0005578 extracellular_matrix COL4A5

61:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005578 extracellular_matrix CADPS2 GO:0030023 extracellular_matrix_constituent_conferring_elasticity ELN GO:0030198 extracellular_matrix_organization_and_biogenesis COL4A6 GO:0030198 extracellular_matrix_organization_and_biogenesis BHLHB3 GO:0030198 extracellular_matrix_organization_and_biogenesis ELN GO:0005201 extracellular_matrix_structural_constituent COL16A1 GO:0005201 extracellular_matrix_structural_constituent COL6A2 GO:0005201 extracellular_matrix_structural_constituent COL6A1 GO:0005201 extracellular_matrix_structural_constituent COL4A6 GO:0005201 extracellular_matrix_structural_constituent COL1A2 GO:0005201 extracellular_matrix_structural_constituent LAMB2 GO:0005201 extracellular_matrix_structural_constituent COL14A1 GO:0005201 extracellular_matrix_structural_constituent COL5A2 GO:0005201 extracellular_matrix_structural_constituent COL1A1 GO:0005201 extracellular_matrix_structural_constituent ELN GO:0005201 extracellular_matrix_structural_constituent COL4A5 GO:0030020 extracellular_matrix_structural_constituent_conferring_tensile_strength COL6A2 GO:0030020 extracellular_matrix_structural_constituent_conferring_tensile_strength COL16A1 GO:0030020 extracellular_matrix_structural_constituent_conferring_tensile_strength COL6A1 GO:0030020 extracellular_matrix_structural_constituent_conferring_tensile_strength COL1A2 GO:0030020 extracellular_matrix_structural_constituent_conferring_tensile_strength COL5A2 GO:0030020 extracellular_matrix_structural_constituent_conferring_tensile_strength COL14A1 GO:0030020 extracellular_matrix_structural_constituent_conferring_tensile_strength COL1A1 GO:0030020 extracellular_matrix_structural_constituent_conferring_tensile_strength COL4A5 GO:0005615 extracellular_space GPC4 GO:0005615 extracellular_space INHA GO:0005615 extracellular_space DSCAM GO:0005615 extracellular_space EGFL6 GO:0005615 extracellular_space CYP26A1 GO:0005615 extracellular_space GLA GO:0005615 extracellular_space SIAT4C GO:0005615 extracellular_space GAL GO:0005615 extracellular_space LRRN3 GO:0005615 extracellular_space FOLR1 GO:0005615 extracellular_space ALPI GO:0005615 extracellular_space IL27RA GO:0005615 extracellular_space CRISP2 GO:0005615 extracellular_space COX6A2 GO:0005615 extracellular_space TLR8 GO:0005615 extracellular_space LRIG1 GO:0005615 extracellular_space SLC2A3 GO:0005615 extracellular_space MFAP4 GO:0005615 extracellular_space CYP19A1 GO:0005615 extracellular_space TNA GO:0005615 extracellular_space FZD7 GO:0005615 extracellular_space NUDT1 GO:0005615 extracellular_space PLAT GO:0005615 extracellular_space GRIN2D GO:0005615 extracellular_space GLB1 GO:0005615 extracellular_space TBL2 GO:0005615 extracellular_space PTPRK GO:0005615 extracellular_space ANGPTL1 GO:0005615 extracellular_space CDH16 GO:0005615 extracellular_space FZD4 GO:0005615 extracellular_space IFNGR2 GO:0005615 extracellular_space GLIPR1 GO:0005615 extracellular_space C6 GO:0005615 extracellular_space SEMA5B GO:0005615 extracellular_space PTPRR GO:0005615 extracellular_space VLDLR GO:0005615 extracellular_space ART3

62:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005615 extracellular_space CART GO:0005615 extracellular_space APOE GO:0005615 extracellular_space TIMP4 GO:0005615 extracellular_space TTR GO:0005615 extracellular_space C1R GO:0005615 extracellular_space COL1A1 GO:0005615 extracellular_space PMP22 GO:0005615 extracellular_space SERPINC1 GO:0005615 extracellular_space COL4A5 GO:0005615 extracellular_space DKK1 GO:0005615 extracellular_space CYP17A1 GO:0005615 extracellular_space COL6A2 GO:0005615 extracellular_space SEMA4C GO:0005615 extracellular_space MMP11 GO:0005615 extracellular_space VTN GO:0005615 extracellular_space CHRDL2 GO:0005615 extracellular_space THBS2 GO:0005615 extracellular_space HS2ST1 GO:0005615 extracellular_space SEMA3E GO:0005615 extracellular_space COL5A2 GO:0005615 extracellular_space PTGES GO:0005615 extracellular_space AFP GO:0005615 extracellular_space FXYD6 GO:0005615 extracellular_space COL6A1 GO:0005615 extracellular_space JAM2 GO:0005615 extracellular_space CDH17 GO:0005615 extracellular_space TPST2 GO:0005615 extracellular_space WISP2 GO:0005615 extracellular_space LY6E GO:0005615 extracellular_space PPIC GO:0005615 extracellular_space FGG GO:0005615 extracellular_space MPZ GO:0005615 extracellular_space GDF10 GO:0005615 extracellular_space APOA2 GO:0005615 extracellular_space EPHA3 GO:0005615 extracellular_space PAP GO:0005615 extracellular_space TGFBI GO:0005615 extracellular_space BMP2 GO:0005615 extracellular_space COL4A6 GO:0005615 extracellular_space COL1A2 GO:0005615 extracellular_space RNF128 GO:0005615 extracellular_space GPC3 GO:0005615 extracellular_space OGN GO:0005615 extracellular_space TNFRSF1A GO:0005615 extracellular_space GDF3 GO:0005615 extracellular_space PTGDS GO:0005615 extracellular_space F2 GO:0005615 extracellular_space AMBP GO:0005615 extracellular_space FN1 GO:0005615 extracellular_space LAMB2 GO:0005615 extracellular_space SORL1 GO:0005615 extracellular_space ADORA2B GO:0005615 extracellular_space CGA GO:0005615 extracellular_space LRP10 GO:0005615 extracellular_space MDK GO:0005615 extracellular_space ACE2 GO:0005615 extracellular_space EMP1 GO:0005615 extracellular_space FBLN1 GO:0005615 extracellular_space ROR1 GO:0043062 extracellular_structure_organization_and_biogenesis COL4A6 GO:0043062 extracellular_structure_organization_and_biogenesis BHLHB3

63:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0043062 extracellular_structure_organization_and_biogenesis ELN GO:0019898 extrinsic_to_membrane GNA11 GO:0019898 extrinsic_to_membrane PRNP GO:0019897 extrinsic_to_plasma_membrane GNA11 GO:0019897 extrinsic_to_plasma_membrane PRNP GO:0046658 extrinsic_to_plasma_membrane,_GPI-anchored PRNP GO:0008290 F-actin_capping_protein_complex CAPZA3 GO:0008290 F-actin_capping_protein_complex CAPZB GO:0006775 fat-soluble_vitamin_metabolism CALB1 GO:0005504 fatty_acid_binding FABP5 GO:0006633 fatty_acid_biosynthesis GGTLA1 GO:0006633 fatty_acid_biosynthesis PRKAA1 GO:0006633 fatty_acid_biosynthesis ELOVL4 GO:0006633 fatty_acid_biosynthesis FEN1 GO:0006633 fatty_acid_biosynthesis PTGDS GO:0009922 fatty_acid_elongase_activity FEN1 GO:0030497 fatty_acid_elongation FEN1 GO:0006631 fatty_acid_metabolism PTGES GO:0006631 fatty_acid_metabolism GGTLA1 GO:0006631 fatty_acid_metabolism PRKAA1 GO:0006631 fatty_acid_metabolism PRKAR2B GO:0006631 fatty_acid_metabolism ELOVL4 GO:0006631 fatty_acid_metabolism FEN1 GO:0006631 fatty_acid_metabolism TNFRSF1A GO:0006631 fatty_acid_metabolism PTGDS GO:0019395 fatty_acid_oxidation PRKAA1 GO:0004312 fatty-acid_synthase_activity FEN1 GO:0007292 female_gamete_generation AFP GO:0007292 female_gamete_generation MSN GO:0008585 female_gonad_development AFP GO:0008585 female_gonad_development INHA GO:0001660 fever PTGER3 GO:0005583 fibrillar_collagen COL5A2 GO:0048256 flap_endonuclease_activity FEN1 GO:0009813 flavonoid_biosynthesis GLB1 GO:0009812 flavonoid_metabolism GLB1 GO:0008517 folate_transporter_activity SLC19A2 GO:0008517 folate_transporter_activity FOLR1 GO:0006760 folic_acid_and_derivative_metabolism FOLR1 GO:0005542 folic_acid_binding SLC19A2 GO:0005542 folic_acid_binding FOLR1 GO:0005542 folic_acid_binding SLC19A1 GO:0046655 folic_acid_metabolism FOLR1 GO:0046884 follicle-stimulating_hormone_secretion INHA GO:0030900 forebrain_development DKK1 GO:0001704 formation_of_primary_germ_layer EPHA3 GO:0001704 formation_of_primary_germ_layer POU5F1 GO:0000082 G1/S_transition_of_mitotic_cell_cycle PPP6C GO:0000080 G1_phase_of_mitotic_cell_cycle ACE2 GO:0000114 G1-specific_transcription_in_mitotic_cell_cycle ACE2 GO:0000086 G2/M_transition_of_mitotic_cell_cycle GADD45A GO:0019376 galactolipid_catabolism GALC GO:0019374 galactolipid_metabolism GALC GO:0015925 galactosidase_activity GLB1 GO:0015925 galactosidase_activity GLA GO:0015925 galactosidase_activity GAL GO:0004336 galactosylceramidase_activity GALC GO:0006683 galactosylceramide_catabolism GALC GO:0006681 galactosylceramide_metabolism GALC GO:0007276 gametogenesis AFP GO:0007276 gametogenesis DNMT3L

64:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007276 gametogenesis MSN GO:0007276 gametogenesis PAX5 GO:0007276 gametogenesis TBPL1 GO:0007276 gametogenesis PRM2 GO:0003840 gamma-glutamyltransferase_activity GGTLA1 GO:0005921 gap_junction CALB2 GO:0015054 gastrin_receptor_activity CCKBR GO:0007369 gastrulation GPC3 GO:0007369 gastrulation EPHA3 GO:0007369 gastrulation POU5F1 GO:0016458 gene_silencing SIRT7 GO:0016251 general_RNA_polymerase_II_transcription_factor_activity CDK8 GO:0004337 geranyltranstransferase_activity GGPS1 GO:0010001 glial_cell_differentiation IGF1 GO:0042063 gliogenesis PAX3 GO:0042063 gliogenesis IGF1 GO:0006094 gluconeogenesis PRKAA1 GO:0006094 gluconeogenesis PGK1 GO:0006041 glucosamine_metabolism GNE GO:0006007 glucose_catabolism LDHA GO:0006007 glucose_catabolism SUCLA2 GO:0006007 glucose_catabolism PGK1 GO:0006007 glucose_catabolism PARG GO:0046323 glucose_import PRKAA1 GO:0006006 glucose_metabolism SUCLA2 GO:0006006 glucose_metabolism LDHA GO:0006006 glucose_metabolism PRKAA1 GO:0006006 glucose_metabolism PARG GO:0006006 glucose_metabolism PGK1 GO:0015758 glucose_transport PRKAA1 GO:0005355 glucose_transporter_activity SLC2A1 GO:0005355 glucose_transporter_activity SLC2A3 GO:0006679 glucosylceramide_biosynthesis PRKAA1 GO:0006678 glucosylceramide_metabolism PRKAA1 GO:0015259 glutamate_channel_activity GRIN2D GO:0008066 glutamate_receptor_activity GRIN2D GO:0007215 glutamate_signaling_pathway GNA11 GO:0005234 glutamate-gated_ion_channel_activity GRIN2D GO:0009064 glutamine_family_amino_acid_metabolism GFPT2 GO:0006541 glutamine_metabolism GFPT2 GO:0004360 glutamine-fructose-6-phosphate_transaminase_(isomerizing)_activity GFPT2 GO:0004230 glutamyl_aminopeptidase_activity ENPEP GO:0006750 glutathione_biosynthesis GGTLA1 GO:0006749 glutathione_metabolism GGTLA1 GO:0006749 glutathione_metabolism GSTA1 GO:0006749 glutathione_metabolism MGST1 GO:0004364 glutathione_transferase_activity GSTA2 GO:0004364 glutathione_transferase_activity GSTP1 GO:0004364 glutathione_transferase_activity GSTA1 GO:0004364 glutathione_transferase_activity MGST1 GO:0004364 glutathione_transferase_activity GSTM3 GO:0006662 glycerol_ether_metabolism GK2 GO:0006662 glycerol_ether_metabolism APOB GO:0004370 glycerol_kinase_activity GK2 GO:0006071 glycerol_metabolism GK2 GO:0046486 glycerolipid_metabolism GK2 GO:0046486 glycerolipid_metabolism APOB GO:0004372 glycine_hydroxymethyltransferase_activity ATIC GO:0009247 glycolipid_biosynthesis PRKAA1 GO:0019377 glycolipid_catabolism GALC GO:0006664 glycolipid_metabolism GALC

65:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006664 glycolipid_metabolism PRKAA1 GO:0006096 glycolysis SUCLA2 GO:0006096 glycolysis LDHA GO:0006096 glycolysis PARG GO:0006096 glycolysis PGK1 GO:0009101 glycoprotein_biosynthesis SIAT4C GO:0009100 glycoprotein_metabolism SIAT4C GO:0005539 glycosaminoglycan_binding VTN GO:0005539 glycosaminoglycan_binding FN1 GO:0005539 glycosaminoglycan_binding APOE GO:0005539 glycosaminoglycan_binding THBS2 GO:0005539 glycosaminoglycan_binding MDK GO:0005539 glycosaminoglycan_binding HDGF GO:0005539 glycosaminoglycan_binding SERPINC1 GO:0030203 glycosaminoglycan_metabolism HS2ST1 GO:0046476 glycosylceramide_biosynthesis PRKAA1 GO:0046477 glycosylceramide_catabolism GALC GO:0006677 glycosylceramide_metabolism GALC GO:0006677 glycosylceramide_metabolism PRKAA1 GO:0046038 GMP_catabolism GMPR2 GO:0046037 GMP_metabolism GMPR2 GO:0003920 GMP_reductase_activity GMPR2 GO:0003920 GMP_reductase_activity GMPR GO:0005794 Golgi_apparatus MGAT5 GO:0005794 Golgi_apparatus PRNP GO:0005794 Golgi_apparatus COPE GO:0005794 Golgi_apparatus RNF128 GO:0005794 Golgi_apparatus APM2 GO:0005794 Golgi_apparatus STX6 GO:0005794 Golgi_apparatus SIAT4C GO:0005794 Golgi_apparatus PTGDS GO:0005798 Golgi_vesicle APM2 GO:0008406 gonad_development AFP GO:0008406 gonad_development INHA GO:0008406 gonad_development AR GO:0008406 gonad_development DDX20 GO:0008406 gonad_development INSL3 GO:0004930 G-protein_coupled_receptor_activity SLC19A2 GO:0004930 G-protein_coupled_receptor_activity FZD7 GO:0004930 G-protein_coupled_receptor_activity GPR45 GO:0004930 G-protein_coupled_receptor_activity PTGER3 GO:0004930 G-protein_coupled_receptor_activity ADORA2B GO:0004930 G-protein_coupled_receptor_activity FZD4 GO:0004930 G-protein_coupled_receptor_activity BRS3 GO:0004930 G-protein_coupled_receptor_activity AGTRAP GO:0004930 G-protein_coupled_receptor_activity CCKBR GO:0004930 G-protein_coupled_receptor_activity INSL3 GO:0004930 G-protein_coupled_receptor_activity GPR6 GO:0016526 G-protein_coupled_receptor_activity,_unknown_ligand INSL3 GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway FZD7 GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway GNA11 GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway GNAI1 GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway PTGER3 GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway FZD4 GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway BRS3 GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway GNB2L1 GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway GAL GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway GPR6 GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway SLC19A2 GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway GRB14 GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway GPR45

66:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway CART GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway ADORA2B GO:0007186 G-protein_coupled_receptor_protein_signaling_pathway CCKBR GO:0007188 G-protein_signaling,_coupled_to_cAMP_nucleotide_second_messenger PTGER3 GO:0007187 G-protein_signaling,_coupled_to_cyclic_nucleotide_second_messenger PTGER3 GO:0007200 G-protein_signaling,_coupled_to_IP3_second_messenger_(phospholipase_C_act PTGER3 GO:0007200 G-protein_signaling,_coupled_to_IP3_second_messenger_(phospholipase_C_act GNB2L1 GO:0007200 G-protein_signaling,_coupled_to_IP3_second_messenger_(phospholipase_C_act GPR6 GO:0001664 G-protein-coupled_receptor_binding CX3CL1 GO:0001664 G-protein-coupled_receptor_binding GAL GO:0006752 group_transfer_coenzyme_metabolism FOLR1 GO:0006752 group_transfer_coenzyme_metabolism ATP6V1E2 GO:0040007 growth BMP2 GO:0040007 growth WISP2 GO:0040007 growth AES GO:0040007 growth GPC3 GO:0040007 growth EMP1 GO:0040007 growth GDF3 GO:0030426 growth_cone DCTN2 GO:0008083 growth_factor_activity BMP2 GO:0008083 growth_factor_activity INHA GO:0008083 growth_factor_activity MDK GO:0008083 growth_factor_activity GDF10 GO:0008083 growth_factor_activity HDGF GO:0008083 growth_factor_activity OGN GO:0008083 growth_factor_activity GDF3 GO:0008083 growth_factor_activity IGF1 GO:0019838 growth_factor_binding WISP2 GO:0005525 GTP_binding GNA11 GO:0005525 GTP_binding ARL4 GO:0005525 GTP_binding GNAI1 GO:0005525 GTP_binding DRG1 GO:0005525 GTP_binding RRAS2 GO:0005096 GTPase_activator_activity TBC1D1 GO:0003924 GTPase_activity GNA11 GO:0003924 GTPase_activity ARL4 GO:0003924 GTPase_activity GNAI1 GO:0003924 GTPase_activity RRAS2 GO:0030695 GTPase_regulator_activity TBC1D1 GO:0030695 GTPase_regulator_activity MCF2 GO:0019001 guanyl_nucleotide_binding GNA11 GO:0019001 guanyl_nucleotide_binding GNAI1 GO:0019001 guanyl_nucleotide_binding ARL4 GO:0019001 guanyl_nucleotide_binding DRG1 GO:0019001 guanyl_nucleotide_binding RRAS2 GO:0005085 guanyl-nucleotide_exchange_factor_activity MCF2 GO:0007507 heart_development GNA11 GO:0007507 heart_development FBLN1 GO:0003773 heat_shock_protein_activity HSPA1A GO:0003773 heat_shock_protein_activity CRYAB GO:0004386 helicase_activity DDX25 GO:0004386 helicase_activity DDX20 GO:0004386 helicase_activity DHX35 GO:0004386 helicase_activity PRH1 GO:0004896 hematopoietin/interferon-class_(D200-domain)_cytokine_receptor_activity IL27RA GO:0004896 hematopoietin/interferon-class_(D200-domain)_cytokine_receptor_activity IFNGR2 GO:0020037 heme_binding HEBP1 GO:0042168 heme_metabolism HEBP1 GO:0015002 heme-copper_terminal_oxidase_activity COX6A2 GO:0015002 heme-copper_terminal_oxidase_activity COX7C GO:0042541 hemoglobin_biosynthesis INHA

67:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0020027 hemoglobin_metabolism INHA GO:0030097 hemopoiesis INHA GO:0030097 hemopoiesis CBFB GO:0030097 hemopoiesis SOX14 GO:0030097 hemopoiesis GMPR2 GO:0007599 hemostasis F2 GO:0007599 hemostasis FGG GO:0007599 hemostasis SERPINC1 GO:0007599 hemostasis TM4SF3 GO:0015012 heparan_sulfate_proteoglycan_biosynthesis HS2ST1 GO:0015014 heparan_sulfate_proteoglycan_biosynthesis,_polysaccharide_chain_biosynthesis HS2ST1 GO:0030201 heparan_sulfate_proteoglycan_metabolism HS2ST1 GO:0008201 heparin_binding VTN GO:0008201 heparin_binding FN1 GO:0008201 heparin_binding APOE GO:0008201 heparin_binding THBS2 GO:0008201 heparin_binding MDK GO:0008201 heparin_binding HDGF GO:0008201 heparin_binding SERPINC1 GO:0030202 heparin_metabolism HS2ST1 GO:0004394 heparin-sulfate_2-sulfotransferase_activity HS2ST1 GO:0000792 heterochromatin DNMT3L GO:0000792 heterochromatin BAZ1B GO:0000792 heterochromatin DNMT3B GO:0046483 heterocycle_metabolism FOLR1 GO:0046483 heterocycle_metabolism HEBP1 GO:0046483 heterocycle_metabolism AMPD2 GO:0046483 heterocycle_metabolism INDO GO:0007157 heterophilic_cell_adhesion LGALS8 GO:0007157 heterophilic_cell_adhesion CLEC2 GO:0007157 heterophilic_cell_adhesion TNA GO:0007157 heterophilic_cell_adhesion PAP GO:0005834 heterotrimeric_G-protein_complex GNA11 GO:0003927 heterotrimeric_G-protein_GTPase_activity GNAI1 GO:0019319 hexose_biosynthesis PRKAA1 GO:0019319 hexose_biosynthesis PGK1 GO:0019320 hexose_catabolism SUCLA2 GO:0019320 hexose_catabolism LDHA GO:0019320 hexose_catabolism PARG GO:0019320 hexose_catabolism PGK1 GO:0019318 hexose_metabolism LDHA GO:0019318 hexose_metabolism SUCLA2 GO:0019318 hexose_metabolism PRKAA1 GO:0019318 hexose_metabolism PARG GO:0019318 hexose_metabolism PGK1 GO:0008645 hexose_transport PRKAA1 GO:0015149 hexose_transporter_activity SLC2A1 GO:0015149 hexose_transporter_activity SLC2A3 GO:0009888 histogenesis DSCAM GO:0009888 histogenesis SOX14 GO:0009888 histogenesis EPHA3 GO:0009888 histogenesis DKK1 GO:0009888 histogenesis POU5F1 GO:0042393 histone_binding ASF1A GO:0004408 holocytochrome-c_synthase_activity HCCS GO:0042592 homeostasis BAP1 GO:0042592 homeostasis PRNP GO:0042592 homeostasis PTGER3 GO:0042592 homeostasis MT2A GO:0042592 homeostasis ACE2 GO:0042592 homeostasis MT1A

68:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0042592 homeostasis PRND GO:0007156 homophilic_cell_adhesion CDH17 GO:0007156 homophilic_cell_adhesion CDH16 GO:0005179 hormone_activity INHA GO:0005179 hormone_activity CART GO:0005179 hormone_activity CGA GO:0005179 hormone_activity GAL GO:0005179 hormone_activity CRH GO:0005179 hormone_activity INSL3 GO:0005179 hormone_activity IGF1 GO:0042446 hormone_biosynthesis CYP17A1 GO:0042446 hormone_biosynthesis HSD17B1 GO:0042446 hormone_biosynthesis HSD3B2 GO:0042446 hormone_biosynthesis STAR GO:0042446 hormone_biosynthesis HSD3B1 GO:0042445 hormone_metabolism AFP GO:0042445 hormone_metabolism CYP17A1 GO:0042445 hormone_metabolism HSD17B1 GO:0042445 hormone_metabolism TTR GO:0042445 hormone_metabolism HSD3B2 GO:0042445 hormone_metabolism STAR GO:0042445 hormone_metabolism HSD3B1 GO:0046879 hormone_secretion INHA GO:0006959 humoral_immune_response C6 GO:0008900 hydrogen/potassium-exchanging_ATPase_activity ATP12A GO:0015078 hydrogen_ion_transporter_activity ATP12A GO:0015078 hydrogen_ion_transporter_activity NDUFB9 GO:0015078 hydrogen_ion_transporter_activity COX6A2 GO:0015078 hydrogen_ion_transporter_activity COX7C GO:0015078 hydrogen_ion_transporter_activity ATP6V1E2 GO:0006818 hydrogen_transport ATP12A GO:0006818 hydrogen_transport ATP6V1E2 GO:0008553 hydrogen-exporting_ATPase_activity,_phosphorylative_mechanism ATP6V1E2 GO:0045255 hydrogen-translocating_F-type_ATPase_complex ATP6V1E2 GO:0016787 hydrolase_activity SPAG5 GO:0016787 hydrolase_activity DUSP6 GO:0016787 hydrolase_activity GLA GO:0016787 hydrolase_activity GAL GO:0016787 hydrolase_activity RRAS2 GO:0016787 hydrolase_activity ATIC GO:0016787 hydrolase_activity ALPI GO:0016787 hydrolase_activity ENPEP GO:0016787 hydrolase_activity NUDT11 GO:0016787 hydrolase_activity RNPEP GO:0016787 hydrolase_activity CASP7 GO:0016787 hydrolase_activity CDKN3 GO:0016787 hydrolase_activity PTPRD GO:0016787 hydrolase_activity CAPNS1 GO:0016787 hydrolase_activity NUDT1 GO:0016787 hydrolase_activity PARG GO:0016787 hydrolase_activity GLB1 GO:0016787 hydrolase_activity PLAT GO:0016787 hydrolase_activity PTPRK GO:0016787 hydrolase_activity DDX20 GO:0016787 hydrolase_activity PTPN13 GO:0016787 hydrolase_activity PTPRR GO:0016787 hydrolase_activity SIRT7 GO:0016787 hydrolase_activity C1R GO:0016787 hydrolase_activity DHX35 GO:0016787 hydrolase_activity GALC GO:0016787 hydrolase_activity MMP11

69:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0016787 hydrolase_activity TENR GO:0016787 hydrolase_activity ARL4 GO:0016787 hydrolase_activity ATP1B1 GO:0016787 hydrolase_activity FAP GO:0016787 hydrolase_activity ATP6V1E2 GO:0016787 hydrolase_activity APEH GO:0016787 hydrolase_activity AFP GO:0016787 hydrolase_activity COL6A1 GO:0016787 hydrolase_activity WISP2 GO:0016787 hydrolase_activity PPP6C GO:0016787 hydrolase_activity ADAMTS19 GO:0016787 hydrolase_activity ZMPSTE24 GO:0016787 hydrolase_activity ATP12A GO:0016787 hydrolase_activity GNA11 GO:0016787 hydrolase_activity GNAI1 GO:0016787 hydrolase_activity RNF128 GO:0016787 hydrolase_activity AMPD2 GO:0016787 hydrolase_activity DDX25 GO:0016787 hydrolase_activity F2 GO:0016787 hydrolase_activity OPLAH GO:0016787 hydrolase_activity NUDT10 GO:0016787 hydrolase_activity BAP1 GO:0016787 hydrolase_activity LAMB2 GO:0016787 hydrolase_activity FEN1 GO:0016787 hydrolase_activity ACE2 GO:0016817 hydrolase_activity,_acting_on_acid_anhydrides DDX25 GO:0016817 hydrolase_activity,_acting_on_acid_anhydrides ATP12A GO:0016817 hydrolase_activity,_acting_on_acid_anhydrides NUDT10 GO:0016817 hydrolase_activity,_acting_on_acid_anhydrides GNA11 GO:0016817 hydrolase_activity,_acting_on_acid_anhydrides ARL4 GO:0016817 hydrolase_activity,_acting_on_acid_anhydrides GNAI1 GO:0016817 hydrolase_activity,_acting_on_acid_anhydrides DDX20 GO:0016817 hydrolase_activity,_acting_on_acid_anhydrides ATP1B1 GO:0016817 hydrolase_activity,_acting_on_acid_anhydrides NUDT11 GO:0016817 hydrolase_activity,_acting_on_acid_anhydrides RRAS2 GO:0016817 hydrolase_activity,_acting_on_acid_anhydrides ATP6V1E2 GO:0016820 hydrolase_activity,_acting_on_acid_anhydrides,_catalyzing_transmembrane_mov ATP12A GO:0016820 hydrolase_activity,_acting_on_acid_anhydrides,_catalyzing_transmembrane_mov ATP1B1 GO:0016820 hydrolase_activity,_acting_on_acid_anhydrides,_catalyzing_transmembrane_mov ATP6V1E2 GO:0016818 hydrolase_activity,_acting_on_acid_anhydrides,_in_phosphorus-containing_anhydATP12A GO:0016818 hydrolase_activity,_acting_on_acid_anhydrides,_in_phosphorus-containing_anhydDDX25 GO:0016818 hydrolase_activity,_acting_on_acid_anhydrides,_in_phosphorus-containing_anhydGNA11 GO:0016818 hydrolase_activity,_acting_on_acid_anhydrides,_in_phosphorus-containing_anhydNUDT10 GO:0016818 hydrolase_activity,_acting_on_acid_anhydrides,_in_phosphorus-containing_anhydGNAI1 GO:0016818 hydrolase_activity,_acting_on_acid_anhydrides,_in_phosphorus-containing_anhydARL4 GO:0016818 hydrolase_activity,_acting_on_acid_anhydrides,_in_phosphorus-containing_anhydDDX20 GO:0016818 hydrolase_activity,_acting_on_acid_anhydrides,_in_phosphorus-containing_anhydATP1B1 GO:0016818 hydrolase_activity,_acting_on_acid_anhydrides,_in_phosphorus-containing_anhydNUDT11 GO:0016818 hydrolase_activity,_acting_on_acid_anhydrides,_in_phosphorus-containing_anhydRRAS2 GO:0016818 hydrolase_activity,_acting_on_acid_anhydrides,_in_phosphorus-containing_anhydATP6V1E2 GO:0016810 hydrolase_activity,_acting_on_carbon-nitrogen_(but_not_peptide)_bonds ATIC GO:0016810 hydrolase_activity,_acting_on_carbon-nitrogen_(but_not_peptide)_bonds GALC GO:0016810 hydrolase_activity,_acting_on_carbon-nitrogen_(but_not_peptide)_bonds SIRT7 GO:0016810 hydrolase_activity,_acting_on_carbon-nitrogen_(but_not_peptide)_bonds OPLAH GO:0016810 hydrolase_activity,_acting_on_carbon-nitrogen_(but_not_peptide)_bonds TENR GO:0016810 hydrolase_activity,_acting_on_carbon-nitrogen_(but_not_peptide)_bonds AMPD2 GO:0016812 hydrolase_activity,_acting_on_carbon-nitrogen_(but_not_peptide)_bonds,_in_cycl OPLAH GO:0016814 hydrolase_activity,_acting_on_carbon-nitrogen_(but_not_peptide)_bonds,_in_cycl ATIC GO:0016814 hydrolase_activity,_acting_on_carbon-nitrogen_(but_not_peptide)_bonds,_in_cycl TENR GO:0016814 hydrolase_activity,_acting_on_carbon-nitrogen_(but_not_peptide)_bonds,_in_cycl AMPD2 GO:0016811 hydrolase_activity,_acting_on_carbon-nitrogen_(but_not_peptide)_bonds,_in_lineaGALC

70:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0016811 hydrolase_activity,_acting_on_carbon-nitrogen_(but_not_peptide)_bonds,_in_lineaSIRT7 GO:0016788 hydrolase_activity,_acting_on_ester_bonds DUSP6 GO:0016788 hydrolase_activity,_acting_on_ester_bonds PTPRD GO:0016788 hydrolase_activity,_acting_on_ester_bonds BAP1 GO:0016788 hydrolase_activity,_acting_on_ester_bonds ALPI GO:0016788 hydrolase_activity,_acting_on_ester_bonds WISP2 GO:0016788 hydrolase_activity,_acting_on_ester_bonds PTPRK GO:0016788 hydrolase_activity,_acting_on_ester_bonds FEN1 GO:0016788 hydrolase_activity,_acting_on_ester_bonds LAMB2 GO:0016788 hydrolase_activity,_acting_on_ester_bonds PPP6C GO:0016788 hydrolase_activity,_acting_on_ester_bonds PTPN13 GO:0016788 hydrolase_activity,_acting_on_ester_bonds CDKN3 GO:0016788 hydrolase_activity,_acting_on_ester_bonds PTPRR GO:0016798 hydrolase_activity,_acting_on_glycosyl_bonds AFP GO:0016798 hydrolase_activity,_acting_on_glycosyl_bonds GALC GO:0016798 hydrolase_activity,_acting_on_glycosyl_bonds PARG GO:0016798 hydrolase_activity,_acting_on_glycosyl_bonds GLB1 GO:0016798 hydrolase_activity,_acting_on_glycosyl_bonds GLA GO:0016798 hydrolase_activity,_acting_on_glycosyl_bonds GAL GO:0016799 hydrolase_activity,_hydrolyzing_N-glycosyl_compounds PARG GO:0004553 hydrolase_activity,_hydrolyzing_O-glycosyl_compounds AFP GO:0004553 hydrolase_activity,_hydrolyzing_O-glycosyl_compounds GALC GO:0004553 hydrolase_activity,_hydrolyzing_O-glycosyl_compounds PARG GO:0004553 hydrolase_activity,_hydrolyzing_O-glycosyl_compounds GLB1 GO:0004553 hydrolase_activity,_hydrolyzing_O-glycosyl_compounds GLA GO:0004553 hydrolase_activity,_hydrolyzing_O-glycosyl_compounds GAL GO:0016836 hydro-lyase_activity PCBD GO:0016836 hydro-lyase_activity CBS GO:0016742 hydroxymethyl-,_formyl-_and_related_transferase_activity ATIC GO:0004421 hydroxymethylglutaryl-CoA_synthase_activity BAP1 GO:0046456 icosanoid_biosynthesis GGTLA1 GO:0046456 icosanoid_biosynthesis PTGDS GO:0006690 icosanoid_metabolism PTGES GO:0006690 icosanoid_metabolism GGTLA1 GO:0006690 icosanoid_metabolism TNFRSF1A GO:0006690 icosanoid_metabolism PTGDS GO:0004953 icosanoid_receptor_activity PTGER3 GO:0019863 IgE_binding MS4A2 GO:0045321 immune_cell_activation CBFB GO:0045321 immune_cell_activation INHA GO:0045321 immune_cell_activation GAL GO:0006955 immune_response INHA GO:0006955 immune_response RNF128 GO:0006955 immune_response PTGER3 GO:0006955 immune_response C6 GO:0006955 immune_response TNFRSF1A GO:0006955 immune_response GAL GO:0006955 immune_response INDO GO:0006955 immune_response F2 GO:0006955 immune_response GGTLA1 GO:0006955 immune_response CBFB GO:0006955 immune_response FN1 GO:0006955 immune_response IL27RA GO:0006955 immune_response TLR8 GO:0006955 immune_response CX3CL1 GO:0006955 immune_response FGG GO:0006955 immune_response LST1 GO:0006955 immune_response PAP GO:0019865 immunoglobulin_binding MS4A2 GO:0006188 IMP_biosynthesis PAICS GO:0003937 IMP_cyclohydrolase_activity ATIC

71:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0046040 IMP_metabolism PAICS GO:0006349 imprinting DNMT3L GO:0006349 imprinting DNMT3B GO:0046218 indolalkylamine_catabolism INDO GO:0006586 indolalkylamine_metabolism INDO GO:0042430 indole_and_derivative_metabolism INDO GO:0042436 indole_derivative_catabolism INDO GO:0042434 indole_derivative_metabolism INDO GO:0004426 indoleamine-pyrrole_2,3-dioxygenase_activity INDO GO:0006917 induction_of_apoptosis INHA GO:0006917 induction_of_apoptosis CASP7 GO:0006917 induction_of_apoptosis APPBP1 GO:0012502 induction_of_programmed_cell_death INHA GO:0012502 induction_of_programmed_cell_death CASP7 GO:0012502 induction_of_programmed_cell_death APPBP1 GO:0006954 inflammatory_response GGTLA1 GO:0006954 inflammatory_response TLR8 GO:0006954 inflammatory_response PTGER3 GO:0006954 inflammatory_response FGG GO:0006954 inflammatory_response TNFRSF1A GO:0006954 inflammatory_response PAP GO:0045087 innate_immune_response GGTLA1 GO:0045087 innate_immune_response PTGER3 GO:0045087 innate_immune_response TLR8 GO:0045087 innate_immune_response FGG GO:0045087 innate_immune_response TNFRSF1A GO:0045087 innate_immune_response PAP GO:0019866 inner_membrane NDUFB9 GO:0019866 inner_membrane COX6A2 GO:0019866 inner_membrane COX7C GO:0019866 inner_membrane ATP6V1E2 GO:0015698 inorganic_anion_transport SLC17A1 GO:0015698 inorganic_anion_transport CLIC6 GO:0015698 inorganic_anion_transport PTGER3 GO:0015103 inorganic_anion_transporter_activity OCA2 GO:0015103 inorganic_anion_transporter_activity SLC17A1 GO:0004970 inotropic_glutamate_receptor_activity GRIN2D GO:0005158 insulin_receptor_binding GRB14 GO:0005520 insulin-like_growth_factor_binding WISP2 GO:0048009 insulin-like_growth_factor_receptor_signaling_pathway IGF1 GO:0016021 integral_to_membrane DSCAM GO:0016021 integral_to_membrane PTGER3 GO:0016021 integral_to_membrane STX6 GO:0016021 integral_to_membrane HNRPM GO:0016021 integral_to_membrane SIAT4C GO:0016021 integral_to_membrane SSR1 GO:0016021 integral_to_membrane GPM6B GO:0016021 integral_to_membrane FLRT3 GO:0016021 integral_to_membrane OCA2 GO:0016021 integral_to_membrane SSPN GO:0016021 integral_to_membrane ELOVL4 GO:0016021 integral_to_membrane ALPI GO:0016021 integral_to_membrane HSD3B2 GO:0016021 integral_to_membrane TLR8 GO:0016021 integral_to_membrane ENPEP GO:0016021 integral_to_membrane ITM2B GO:0016021 integral_to_membrane SLC7A11 GO:0016021 integral_to_membrane LRIG1 GO:0016021 integral_to_membrane SLC2A3 GO:0016021 integral_to_membrane ROPN1 GO:0016021 integral_to_membrane LST1

72:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0016021 integral_to_membrane MGAT5 GO:0016021 integral_to_membrane FZD7 GO:0016021 integral_to_membrane PTPRD GO:0016021 integral_to_membrane BAMBI GO:0016021 integral_to_membrane GRIN2D GO:0016021 integral_to_membrane PTPRK GO:0016021 integral_to_membrane CDH16 GO:0016021 integral_to_membrane GPC5 GO:0016021 integral_to_membrane FZD4 GO:0016021 integral_to_membrane IFNGR2 GO:0016021 integral_to_membrane GLIPR1 GO:0016021 integral_to_membrane SEMA5B GO:0016021 integral_to_membrane PTPRR GO:0016021 integral_to_membrane VLDLR GO:0016021 integral_to_membrane SLC19A2 GO:0016021 integral_to_membrane ITGBL1 GO:0016021 integral_to_membrane CX3CL1 GO:0016021 integral_to_membrane PMP22 GO:0016021 integral_to_membrane SLCO4A1 GO:0016021 integral_to_membrane SEMA4C GO:0016021 integral_to_membrane COX7C GO:0016021 integral_to_membrane PLSCR3 GO:0016021 integral_to_membrane SCN9A GO:0016021 integral_to_membrane IFITM1 GO:0016021 integral_to_membrane ATP1B1 GO:0016021 integral_to_membrane FAP GO:0016021 integral_to_membrane PRM2 GO:0016021 integral_to_membrane ATP6V1E2 GO:0016021 integral_to_membrane PTGES GO:0016021 integral_to_membrane GGTLA1 GO:0016021 integral_to_membrane TAPBP GO:0016021 integral_to_membrane FXYD6 GO:0016021 integral_to_membrane JAM2 GO:0016021 integral_to_membrane CDH17 GO:0016021 integral_to_membrane TPST2 GO:0016021 integral_to_membrane NRXN3 GO:0016021 integral_to_membrane CACNA1C GO:0016021 integral_to_membrane MPZ GO:0016021 integral_to_membrane SLC19A1 GO:0016021 integral_to_membrane CLEC2 GO:0016021 integral_to_membrane EPHA3 GO:0016021 integral_to_membrane HSD3B1 GO:0016021 integral_to_membrane ATP12A GO:0016021 integral_to_membrane SLC2A1 GO:0016021 integral_to_membrane SLC17A1 GO:0016021 integral_to_membrane MS4A2 GO:0016021 integral_to_membrane RNF128 GO:0016021 integral_to_membrane BRS3 GO:0016021 integral_to_membrane GPC3 GO:0016021 integral_to_membrane TNFRSF1A GO:0016021 integral_to_membrane SEMA6A GO:0016021 integral_to_membrane GPR6 GO:0016021 integral_to_membrane GPR45 GO:0016021 integral_to_membrane SLCO2A1 GO:0016021 integral_to_membrane SORL1 GO:0016021 integral_to_membrane ADORA2B GO:0016021 integral_to_membrane LRP10 GO:0016021 integral_to_membrane ACE2 GO:0016021 integral_to_membrane EMP1 GO:0016021 integral_to_membrane SCARB1 GO:0016021 integral_to_membrane ROR1

73:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0016021 integral_to_membrane CCKBR GO:0005887 integral_to_plasma_membrane BAMBI GO:0005887 integral_to_plasma_membrane SLC17A1 GO:0005887 integral_to_plasma_membrane MS4A2 GO:0005887 integral_to_plasma_membrane GRIN2D GO:0005887 integral_to_plasma_membrane DSCAM GO:0005887 integral_to_plasma_membrane GPC5 GO:0005887 integral_to_plasma_membrane HNRPM GO:0005887 integral_to_plasma_membrane GPC3 GO:0005887 integral_to_plasma_membrane SCN9A GO:0005887 integral_to_plasma_membrane ATP1B1 GO:0005887 integral_to_plasma_membrane PTPRR GO:0005887 integral_to_plasma_membrane ITGBL1 GO:0005887 integral_to_plasma_membrane TAPBP GO:0005887 integral_to_plasma_membrane CDH17 GO:0005887 integral_to_plasma_membrane SLCO2A1 GO:0005887 integral_to_plasma_membrane CACNA1C GO:0005887 integral_to_plasma_membrane SLC19A1 GO:0005887 integral_to_plasma_membrane SLC2A3 GO:0005887 integral_to_plasma_membrane CLEC2 GO:0005887 integral_to_plasma_membrane ROR1 GO:0008305 integrin_complex ITGBL1 GO:0007229 integrin-mediated_signaling_pathway ITGBL1 GO:0005911 intercellular_junction PMP22 GO:0005911 intercellular_junction CALB2 GO:0045216 intercellular_junction_assembly_and/or_maintenance MPZ GO:0045217 intercellular_junction_maintenance MPZ GO:0042095 interferon-gamma_biosynthesis INHA GO:0019965 interleukin_binding IL27RA GO:0004907 interleukin_receptor_activity IL27RA GO:0045513 interleukin-27_binding IL27RA GO:0045509 interleukin-27_receptor_activity IL27RA GO:0005622 intracellular NARS GO:0005622 intracellular TLE4 GO:0005622 intracellular H2AFY GO:0005622 intracellular TPD52L1 GO:0005622 intracellular STAR GO:0005622 intracellular GLA GO:0005622 intracellular TBX3 GO:0005622 intracellular EKI1 GO:0005622 intracellular HCCS GO:0005622 intracellular SSPN GO:0005622 intracellular MTA3 GO:0005622 intracellular PGK1 GO:0005622 intracellular COX6A2 GO:0005622 intracellular SALL1 GO:0005622 intracellular PAX5 GO:0005622 intracellular ROPN1 GO:0005622 intracellular CDK8 GO:0005622 intracellular WBSCR22 GO:0005622 intracellular POU5F1 GO:0005622 intracellular ASF1A GO:0005622 intracellular CPR8 GO:0005622 intracellular AHR GO:0005622 intracellular ARPC1A GO:0005622 intracellular PARG GO:0005622 intracellular CEBPD GO:0005622 intracellular AES GO:0005622 intracellular PCBD GO:0005622 intracellular CKAP1 GO:0005622 intracellular DDX20

74:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005622 intracellular PRH1 GO:0005622 intracellular MT1A GO:0005622 intracellular H1F0 GO:0005622 intracellular HEY1 GO:0005622 intracellular SIRT7 GO:0005622 intracellular IDI1 GO:0005622 intracellular DNMT3L GO:0005622 intracellular TESK2 GO:0005622 intracellular ACAS2L GO:0005622 intracellular NDUFB9 GO:0005622 intracellular DNCL2A GO:0005622 intracellular ATBF1 GO:0005622 intracellular PRKAA1 GO:0005622 intracellular UBA2 GO:0005622 intracellular CXXC4 GO:0005622 intracellular GK2 GO:0005622 intracellular AASS GO:0005622 intracellular TENR GO:0005622 intracellular HEBP1 GO:0005622 intracellular KLF12 GO:0005622 intracellular PWP1 GO:0005622 intracellular TLX2 GO:0005622 intracellular MLL GO:0005622 intracellular DNMT3B GO:0005622 intracellular APEH GO:0005622 intracellular PRM2 GO:0005622 intracellular ETS2 GO:0005622 intracellular CAPZA3 GO:0005622 intracellular PTGES GO:0005622 intracellular CDC42EP4 GO:0005622 intracellular CBFB GO:0005622 intracellular RPS8 GO:0005622 intracellular HMGB2 GO:0005622 intracellular TBC1D1 GO:0005622 intracellular HESX1 GO:0005622 intracellular MYOZ2 GO:0005622 intracellular ARID3A GO:0005622 intracellular NANOG GO:0005622 intracellular GGPS1 GO:0005622 intracellular HSD3B1 GO:0005622 intracellular MYH11 GO:0005622 intracellular TERF1 GO:0005622 intracellular YBX2 GO:0005622 intracellular HNF3B GO:0005622 intracellular ARNTL GO:0005622 intracellular RNF128 GO:0005622 intracellular CRYAB GO:0005622 intracellular FOXA1 GO:0005622 intracellular FEN1 GO:0005622 intracellular MSN GO:0005622 intracellular FHL2 GO:0005622 intracellular CBS GO:0005622 intracellular SPAG5 GO:0005622 intracellular DUSP6 GO:0005622 intracellular CALB1 GO:0005622 intracellular RPL18A GO:0005622 intracellular EPAS1 GO:0005622 intracellular CYP26A1 GO:0005622 intracellular RPL28 GO:0005622 intracellular JARID2 GO:0005622 intracellular HNRPM

75:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005622 intracellular STX6 GO:0005622 intracellular SIAT4C GO:0005622 intracellular HDGF GO:0005622 intracellular RRAS2 GO:0005622 intracellular SOX30 GO:0005622 intracellular SYCP2 GO:0005622 intracellular MID1 GO:0005622 intracellular ELOVL4 GO:0005622 intracellular LYAR GO:0005622 intracellular TRPS1 GO:0005622 intracellular HSD3B2 GO:0005622 intracellular CKB GO:0005622 intracellular MGST1 GO:0005622 intracellular NRBP GO:0005622 intracellular EPPK1 GO:0005622 intracellular RPL29 GO:0005622 intracellular MGAT5 GO:0005622 intracellular AP2B1 GO:0005622 intracellular ZFP36L2 GO:0005622 intracellular GLB1 GO:0005622 intracellular NOL6 GO:0005622 intracellular PAX3 GO:0005622 intracellular TLE1 GO:0005622 intracellular TCF7L2 GO:0005622 intracellular PTPN13 GO:0005622 intracellular CAPZB GO:0005622 intracellular NR2F1 GO:0005622 intracellular TBX2 GO:0005622 intracellular CUL1 GO:0005622 intracellular CITED1 GO:0005622 intracellular CETN3 GO:0005622 intracellular SHOX2 GO:0005622 intracellular PRNP GO:0005622 intracellular BHLHB3 GO:0005622 intracellular EMX2 GO:0005622 intracellular CCT2 GO:0005622 intracellular APOB GO:0005622 intracellular CLC GO:0005622 intracellular CIRBP GO:0005622 intracellular BAZ1B GO:0005622 intracellular GFPT2 GO:0005622 intracellular CYP17A1 GO:0005622 intracellular GALC GO:0005622 intracellular TCEA2 GO:0005622 intracellular COPE GO:0005622 intracellular ARL4 GO:0005622 intracellular GADD45A GO:0005622 intracellular SOX14 GO:0005622 intracellular TNNT3 GO:0005622 intracellular COX7C GO:0005622 intracellular BIRC3 GO:0005622 intracellular SCAP2 GO:0005622 intracellular SSBP1 GO:0005622 intracellular ATP6V1E2 GO:0005622 intracellular TMLHE GO:0005622 intracellular MLF1 GO:0005622 intracellular TAPBP GO:0005622 intracellular MAPK4 GO:0005622 intracellular WISP2 GO:0005622 intracellular NAP1L1 GO:0005622 intracellular PLEKHA1

76:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005622 intracellular APM2 GO:0005622 intracellular ID2 GO:0005622 intracellular NSEP1 GO:0005622 intracellular CADPS2 GO:0005622 intracellular SUCLA2 GO:0005622 intracellular CKMT2 GO:0005622 intracellular LIN28 GO:0005622 intracellular SLC2A1 GO:0005622 intracellular HDLBP GO:0005622 intracellular CBR3 GO:0005622 intracellular AR GO:0005622 intracellular TIP120B GO:0005622 intracellular TK1 GO:0005622 intracellular TBPL1 GO:0005622 intracellular PTGDS GO:0005622 intracellular STMN1 GO:0005622 intracellular ZFP36L1 GO:0005622 intracellular BAP1 GO:0005622 intracellular LAMB2 GO:0005622 intracellular TCF8 GO:0005622 intracellular ACE2 GO:0005622 intracellular NFIA GO:0006886 intracellular_protein_transport FOLR1 GO:0006886 intracellular_protein_transport COPE GO:0006886 intracellular_protein_transport ARNTL GO:0006886 intracellular_protein_transport ARL4 GO:0006886 intracellular_protein_transport APM2 GO:0006886 intracellular_protein_transport SORL1 GO:0006886 intracellular_protein_transport STX6 GO:0006886 intracellular_protein_transport CLC GO:0006886 intracellular_protein_transport POU5F1 GO:0007242 intracellular_signaling_cascade PRKAA1 GO:0007242 intracellular_signaling_cascade GNA11 GO:0007242 intracellular_signaling_cascade SLC2A1 GO:0007242 intracellular_signaling_cascade RACGAP1 GO:0007242 intracellular_signaling_cascade ARL4 GO:0007242 intracellular_signaling_cascade PTGER3 GO:0007242 intracellular_signaling_cascade TNFRSF1A GO:0007242 intracellular_signaling_cascade MT1A GO:0007242 intracellular_signaling_cascade PTPN13 GO:0007242 intracellular_signaling_cascade DSCR1L2 GO:0007242 intracellular_signaling_cascade RRAS2 GO:0007242 intracellular_signaling_cascade STMN1 GO:0007242 intracellular_signaling_cascade LRRN3 GO:0007242 intracellular_signaling_cascade CDC42EP4 GO:0007242 intracellular_signaling_cascade GRB14 GO:0007242 intracellular_signaling_cascade MSN GO:0007242 intracellular_signaling_cascade PDZK1 GO:0007242 intracellular_signaling_cascade NRBP GO:0046907 intracellular_transport FOLR1 GO:0046907 intracellular_transport ARNTL GO:0046907 intracellular_transport COPE GO:0046907 intracellular_transport ARL4 GO:0046907 intracellular_transport SORL1 GO:0046907 intracellular_transport APM2 GO:0046907 intracellular_transport STX6 GO:0046907 intracellular_transport DNCL2A GO:0046907 intracellular_transport PDZK1 GO:0046907 intracellular_transport CLC GO:0046907 intracellular_transport POU5F1 GO:0016860 intramolecular_oxidoreductase_activity PTGES

77:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0016860 intramolecular_oxidoreductase_activity IDI1 GO:0016860 intramolecular_oxidoreductase_activity HSD3B2 GO:0016860 intramolecular_oxidoreductase_activity PTGDS GO:0016860 intramolecular_oxidoreductase_activity HSD3B1 GO:0016863 intramolecular_oxidoreductase_activity,_transposing_C=C_bonds IDI1 GO:0016863 intramolecular_oxidoreductase_activity,_transposing_C=C_bonds HSD3B2 GO:0016863 intramolecular_oxidoreductase_activity,_transposing_C=C_bonds HSD3B1 GO:0005216 ion_channel_activity MID1 GO:0005216 ion_channel_activity FXYD6 GO:0005216 ion_channel_activity GRIN2D GO:0005216 ion_channel_activity CLIC6 GO:0005216 ion_channel_activity CACNA1C GO:0005216 ion_channel_activity SCN9A GO:0050801 ion_homeostasis PRNP GO:0050801 ion_homeostasis MT2A GO:0050801 ion_homeostasis ACE2 GO:0050801 ion_homeostasis PRND GO:0050801 ion_homeostasis MT1A GO:0006811 ion_transport ATP12A GO:0006811 ion_transport SLC17A1 GO:0006811 ion_transport GRIN2D GO:0006811 ion_transport CLIC6 GO:0006811 ion_transport PTGER3 GO:0006811 ion_transport SCN9A GO:0006811 ion_transport ATP1B1 GO:0006811 ion_transport ATP6V1E2 GO:0006811 ion_transport MID1 GO:0006811 ion_transport FXYD6 GO:0006811 ion_transport SLCO2A1 GO:0006811 ion_transport CACNA1C GO:0006811 ion_transport SLCO4A1 GO:0015075 ion_transporter_activity ATP12A GO:0015075 ion_transporter_activity OCA2 GO:0015075 ion_transporter_activity NDUFB9 GO:0015075 ion_transporter_activity SLC17A1 GO:0015075 ion_transporter_activity COX6A2 GO:0015075 ion_transporter_activity SLCO2A1 GO:0015075 ion_transporter_activity COX7C GO:0015075 ion_transporter_activity ATP1B1 GO:0015075 ion_transporter_activity ATP6V1E2 GO:0008328 ionotropic_glutamate_receptor_complex GRIN2D GO:0016853 isomerase_activity PTGES GO:0016853 isomerase_activity CPR8 GO:0016853 isomerase_activity IDI1 GO:0016853 isomerase_activity GNE GO:0016853 isomerase_activity HSD3B2 GO:0016853 isomerase_activity PPIC GO:0016853 isomerase_activity PROSC GO:0016853 isomerase_activity HSD3B1 GO:0016853 isomerase_activity PTGDS GO:0004452 isopentenyl-diphosphate_delta-isomerase_activity IDI1 GO:0019840 isoprenoid_binding TTR GO:0019840 isoprenoid_binding PTGDS GO:0008299 isoprenoid_biosynthesis IDI1 GO:0008299 isoprenoid_biosynthesis GGPS1 GO:0006720 isoprenoid_metabolism IDI1 GO:0006720 isoprenoid_metabolism GGPS1 GO:0007254 JNK_cascade MSN GO:0007254 JNK_cascade NRBP GO:0042656 JUN_kinase_kinase_kinase_kinase_activity MSN GO:0001822 kidney_development ANXA4

78:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0019209 kinase_activator_activity PRKAA1 GO:0016301 kinase_activity DUSP6 GO:0016301 kinase_activity CKMT2 GO:0016301 kinase_activity PRKAA1 GO:0016301 kinase_activity PRKAR2B GO:0016301 kinase_activity GK2 GO:0016301 kinase_activity UMPK GO:0016301 kinase_activity TK1 GO:0016301 kinase_activity EKI1 GO:0016301 kinase_activity PRKAR2A GO:0016301 kinase_activity OCA2 GO:0016301 kinase_activity TESK2 GO:0016301 kinase_activity PGK1 GO:0016301 kinase_activity MAPK4 GO:0016301 kinase_activity GNE GO:0016301 kinase_activity MSN GO:0016301 kinase_activity CKB GO:0016301 kinase_activity CCT2 GO:0016301 kinase_activity CDK8 GO:0016301 kinase_activity EPHA3 GO:0016301 kinase_activity NRBP GO:0016301 kinase_activity ROR1 GO:0016301 kinase_activity MAP3K5 GO:0019900 kinase_binding GNB2L1 GO:0019900 kinase_binding PTPRR GO:0019207 kinase_regulator_activity SPA17 GO:0019207 kinase_regulator_activity PRKAA1 GO:0019207 kinase_regulator_activity PRKAR2B GO:0019207 kinase_regulator_activity PRKAR2A GO:0005871 kinesin_complex MYH11 GO:0005871 kinesin_complex STMN1 GO:0005871 kinesin_complex MID1 GO:0005871 kinesin_complex LAMB2 GO:0005871 kinesin_complex STX6 GO:0005871 kinesin_complex SYCP2 GO:0000776 kinetochore SPAG5 GO:0004457 lactate_dehydrogenase_activity LDHA GO:0015934 large_ribosomal_subunit RPL29 GO:0015934 large_ribosomal_subunit RPL18A GO:0015934 large_ribosomal_subunit RPL28 GO:0005770 late_endosome RNF128 GO:0007612 learning PRKAR2B GO:0007611 learning_and/or_memory PRKAR2B GO:0007611 learning_and/or_memory CRH GO:0019370 leukotriene_biosynthesis GGTLA1 GO:0006691 leukotriene_metabolism GGTLA1 GO:0004879 ligand-dependent_nuclear_receptor_activity AHR GO:0004879 ligand-dependent_nuclear_receptor_activity AR GO:0004879 ligand-dependent_nuclear_receptor_activity NR2F1 GO:0015276 ligand-gated_ion_channel_activity GRIN2D GO:0016874 ligase_activity SUCLA2 GO:0016874 ligase_activity UBA2 GO:0016874 ligase_activity ACAS2L GO:0016874 ligase_activity NARS GO:0016874 ligase_activity PAICS GO:0016874 ligase_activity WARS GO:0016874 ligase_activity RNF128 GO:0016874 ligase_activity CDH16 GO:0016876 ligase_activity,_forming_aminoacyl-tRNA_and_related_compounds NARS GO:0016876 ligase_activity,_forming_aminoacyl-tRNA_and_related_compounds WARS GO:0016876 ligase_activity,_forming_aminoacyl-tRNA_and_related_compounds CDH16

79:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0016879 ligase_activity,_forming_carbon-nitrogen_bonds PAICS GO:0016879 ligase_activity,_forming_carbon-nitrogen_bonds RNF128 GO:0016875 ligase_activity,_forming_carbon-oxygen_bonds NARS GO:0016875 ligase_activity,_forming_carbon-oxygen_bonds WARS GO:0016875 ligase_activity,_forming_carbon-oxygen_bonds CDH16 GO:0016877 ligase_activity,_forming_carbon-sulfur_bonds SUCLA2 GO:0016877 ligase_activity,_forming_carbon-sulfur_bonds ACAS2L GO:0016886 ligase_activity,_forming_phosphoric_ester_bonds NARS GO:0016886 ligase_activity,_forming_phosphoric_ester_bonds WARS GO:0016886 ligase_activity,_forming_phosphoric_ester_bonds CDH16 GO:0016298 lipase_activity WISP2 GO:0016298 lipase_activity LAMB2 GO:0008289 lipid_binding FABP5 GO:0008289 lipid_binding ANXA4 GO:0008289 lipid_binding APOE GO:0008289 lipid_binding HMGB2 GO:0008289 lipid_binding PLEKHA1 GO:0008289 lipid_binding STAR GO:0008289 lipid_binding ANXA3 GO:0008289 lipid_binding ANXA9 GO:0008289 lipid_binding APOA2 GO:0008610 lipid_biosynthesis CYP17A1 GO:0008610 lipid_biosynthesis PRKAA1 GO:0008610 lipid_biosynthesis STAR GO:0008610 lipid_biosynthesis EKI1 GO:0008610 lipid_biosynthesis PTGDS GO:0008610 lipid_biosynthesis GGTLA1 GO:0008610 lipid_biosynthesis IDI1 GO:0008610 lipid_biosynthesis ELOVL4 GO:0008610 lipid_biosynthesis HSD17B1 GO:0008610 lipid_biosynthesis GNE GO:0008610 lipid_biosynthesis FEN1 GO:0008610 lipid_biosynthesis HSD3B2 GO:0008610 lipid_biosynthesis GGPS1 GO:0008610 lipid_biosynthesis HSD3B1 GO:0016042 lipid_catabolism GALC GO:0016042 lipid_catabolism WISP2 GO:0016042 lipid_catabolism LAMB2 GO:0006629 lipid_metabolism CYP17A1 GO:0006629 lipid_metabolism GALC GO:0006629 lipid_metabolism PRKAA1 GO:0006629 lipid_metabolism PRKAR2B GO:0006629 lipid_metabolism GK2 GO:0006629 lipid_metabolism STAR GO:0006629 lipid_metabolism EKI1 GO:0006629 lipid_metabolism PTGES GO:0006629 lipid_metabolism AFP GO:0006629 lipid_metabolism GGTLA1 GO:0006629 lipid_metabolism HSD17B1 GO:0006629 lipid_metabolism ELOVL4 GO:0006629 lipid_metabolism WISP2 GO:0006629 lipid_metabolism HSD3B2 GO:0006629 lipid_metabolism GGPS1 GO:0006629 lipid_metabolism HSD3B1 GO:0006629 lipid_metabolism HDLBP GO:0006629 lipid_metabolism TNFRSF1A GO:0006629 lipid_metabolism VLDLR GO:0006629 lipid_metabolism PTGDS GO:0006629 lipid_metabolism IDI1 GO:0006629 lipid_metabolism GNE GO:0006629 lipid_metabolism ALDH1A3

80:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006629 lipid_metabolism FEN1 GO:0006629 lipid_metabolism LAMB2 GO:0006629 lipid_metabolism SORL1 GO:0006629 lipid_metabolism LRP10 GO:0006629 lipid_metabolism CCT2 GO:0006629 lipid_metabolism APOB GO:0045121 lipid_raft MS4A2 GO:0045121 lipid_raft PRNP GO:0006869 lipid_transport HDLBP GO:0006869 lipid_transport APOE GO:0006869 lipid_transport SORL1 GO:0006869 lipid_transport STAR GO:0006869 lipid_transport LRP10 GO:0006869 lipid_transport PDZK1 GO:0006869 lipid_transport APOA2 GO:0006869 lipid_transport APOB GO:0006869 lipid_transport VLDLR GO:0005319 lipid_transporter_activity HDLBP GO:0005319 lipid_transporter_activity APOE GO:0005319 lipid_transporter_activity SORL1 GO:0005319 lipid_transporter_activity STAR GO:0005319 lipid_transporter_activity APOA2 GO:0005319 lipid_transporter_activity VLDLR GO:0009103 lipopolysaccharide_biosynthesis GNE GO:0008653 lipopolysaccharide_metabolism GNE GO:0008034 lipoprotein_binding LRP10 GO:0042157 lipoprotein_metabolism APOE GO:0042157 lipoprotein_metabolism APOA2 GO:0030228 lipoprotein_receptor_activity LRP10 GO:0004459 L-lactate_dehydrogenase_activity LDHA GO:0007626 locomotory_behavior CALB1 GO:0007616 long-term_memory CRH GO:0030169 low-density_lipoprotein_binding LRP10 GO:0005041 low-density_lipoprotein_receptor_activity LRP10 GO:0006558 L-phenylalanine_metabolism PCBD GO:0006563 L-serine_metabolism CBS GO:0016829 lyase_activity PAICS GO:0016829 lyase_activity PCBD GO:0016829 lyase_activity HCCS GO:0016829 lyase_activity CBS GO:0007515 lymph_gland_development TNFRSF1A GO:0046649 lymphocyte_activation INHA GO:0046649 lymphocyte_activation CBFB GO:0046649 lymphocyte_activation GAL GO:0030098 lymphocyte_differentiation CBFB GO:0030098 lymphocyte_differentiation INHA GO:0046651 lymphocyte_proliferation GAL GO:0005764 lysosome GALC GO:0005764 lysosome GLB1 GO:0005764 lysosome GLA GO:0005764 lysosome MT1A GO:0005764 lysosome ATP6V1E2 GO:0001619 lysosphingolipid_and_lysophosphatidic_acid_receptor_activity GPR6 GO:0000323 lytic_vacuole CPR8 GO:0000323 lytic_vacuole GALC GO:0000323 lytic_vacuole GLB1 GO:0000323 lytic_vacuole GLA GO:0000323 lytic_vacuole MT1A GO:0000323 lytic_vacuole ATP6V1E2 GO:0000279 M_phase TERF1 GO:0000279 M_phase SPAG5

81:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0000279 M_phase STMN1 GO:0000279 M_phase CETN3 GO:0000279 M_phase ACE2 GO:0000279 M_phase CDK8 GO:0000279 M_phase SYCP2 GO:0000279 M_phase PRM2 GO:0000087 M_phase_of_mitotic_cell_cycle TERF1 GO:0000087 M_phase_of_mitotic_cell_cycle STMN1 GO:0000087 M_phase_of_mitotic_cell_cycle SPAG5 GO:0000087 M_phase_of_mitotic_cell_cycle CETN3 GO:0000087 M_phase_of_mitotic_cell_cycle ACE2 GO:0000087 M_phase_of_mitotic_cell_cycle CDK8 GO:0000087 M_phase_of_mitotic_cell_cycle PRM2 GO:0000072 M_phase_specific_microtubule_process STMN1 GO:0009059 macromolecule_biosynthesis CYP17A1 GO:0009059 macromolecule_biosynthesis PRKAA1 GO:0009059 macromolecule_biosynthesis INHA GO:0009059 macromolecule_biosynthesis NARS GO:0009059 macromolecule_biosynthesis RPL18A GO:0009059 macromolecule_biosynthesis GADD45A GO:0009059 macromolecule_biosynthesis RPL28 GO:0009059 macromolecule_biosynthesis STAR GO:0009059 macromolecule_biosynthesis EIF3S5 GO:0009059 macromolecule_biosynthesis HS2ST1 GO:0009059 macromolecule_biosynthesis SIAT4C GO:0009059 macromolecule_biosynthesis EKI1 GO:0009059 macromolecule_biosynthesis ATP6V1E2 GO:0009059 macromolecule_biosynthesis ATIC GO:0009059 macromolecule_biosynthesis GGTLA1 GO:0009059 macromolecule_biosynthesis HSD17B1 GO:0009059 macromolecule_biosynthesis ELOVL4 GO:0009059 macromolecule_biosynthesis PGK1 GO:0009059 macromolecule_biosynthesis RPS8 GO:0009059 macromolecule_biosynthesis WARS GO:0009059 macromolecule_biosynthesis HSD3B2 GO:0009059 macromolecule_biosynthesis GGPS1 GO:0009059 macromolecule_biosynthesis HSD3B1 GO:0009059 macromolecule_biosynthesis RPL29 GO:0009059 macromolecule_biosynthesis RNF128 GO:0009059 macromolecule_biosynthesis CDH16 GO:0009059 macromolecule_biosynthesis AMPD2 GO:0009059 macromolecule_biosynthesis TBPL1 GO:0009059 macromolecule_biosynthesis PTGDS GO:0009059 macromolecule_biosynthesis IDI1 GO:0009059 macromolecule_biosynthesis GNE GO:0009059 macromolecule_biosynthesis PAICS GO:0009059 macromolecule_biosynthesis FEN1 GO:0009059 macromolecule_biosynthesis GFPT2 GO:0009057 macromolecule_catabolism SPAG5 GO:0009057 macromolecule_catabolism MMP11 GO:0009057 macromolecule_catabolism UBA2 GO:0009057 macromolecule_catabolism PLAT GO:0009057 macromolecule_catabolism TENR GO:0009057 macromolecule_catabolism ARNTL GO:0009057 macromolecule_catabolism RNF128 GO:0009057 macromolecule_catabolism FAP GO:0009057 macromolecule_catabolism APEH GO:0009057 macromolecule_catabolism F2 GO:0009057 macromolecule_catabolism COL6A1 GO:0009057 macromolecule_catabolism BAP1 GO:0009057 macromolecule_catabolism ENPEP

82:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0009057 macromolecule_catabolism C1R GO:0009057 macromolecule_catabolism ADAMTS19 GO:0009057 macromolecule_catabolism ZMPSTE24 GO:0009057 macromolecule_catabolism ACE2 GO:0009057 macromolecule_catabolism RNPEP GO:0009057 macromolecule_catabolism CASP7 GO:0030225 macrophage_differentiation INHA GO:0000287 magnesium_ion_binding ATP12A GO:0000287 magnesium_ion_binding IDI1 GO:0000287 magnesium_ion_binding GRIN2D GO:0000287 magnesium_ion_binding ALPI GO:0000287 magnesium_ion_binding FEN1 GO:0004724 magnesium-dependent_protein_serine/threonine_phosphatase_activity DUSP6 GO:0006092 main_pathways_of_carbohydrate_metabolism LDHA GO:0006092 main_pathways_of_carbohydrate_metabolism SUCLA2 GO:0006092 main_pathways_of_carbohydrate_metabolism PRKAA1 GO:0006092 main_pathways_of_carbohydrate_metabolism PARG GO:0006092 main_pathways_of_carbohydrate_metabolism PGK1 GO:0048232 male_gamete_generation DNMT3L GO:0048232 male_gamete_generation PAX5 GO:0048232 male_gamete_generation TBPL1 GO:0048232 male_gamete_generation PRM2 GO:0008584 male_gonad_development AR GO:0008584 male_gonad_development INSL3 GO:0030145 manganese_ion_binding FEN1 GO:0030145 manganese_ion_binding PPP6C GO:0004707 MAP_kinase_activity MAPK4 GO:0008349 MAP_kinase_kinase_kinase_kinase_activity MSN GO:0017017 MAP_kinase_phosphatase_activity DUSP6 GO:0000165 MAPKKK_cascade LRRN3 GO:0000165 MAPKKK_cascade PRKAA1 GO:0000165 MAPKKK_cascade MSN GO:0000119 mediator_complex CDK8 GO:0007126 meiosis SYCP2 GO:0007127 meiosis_I SYCP2 GO:0007128 meiotic_prophase_I SYCP2 GO:0016020 membrane DSCAM GO:0016020 membrane CLIC6 GO:0016020 membrane PTGER3 GO:0016020 membrane SSR1 GO:0016020 membrane SPA17 GO:0016020 membrane FLRT3 GO:0016020 membrane SSPN GO:0016020 membrane FOLR1 GO:0016020 membrane COX6A2 GO:0016020 membrane ENPEP GO:0016020 membrane SLC2A3 GO:0016020 membrane ROPN1 GO:0016020 membrane POU5F1 GO:0016020 membrane LST1 GO:0016020 membrane FZD7 GO:0016020 membrane PTPRD GO:0016020 membrane BAMBI GO:0016020 membrane PTPRK GO:0016020 membrane CDH16 GO:0016020 membrane VLDLR GO:0016020 membrane PTPRR GO:0016020 membrane NDUFB9 GO:0016020 membrane CX3CL1 GO:0016020 membrane PMP22 GO:0016020 membrane COL4A5

83:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0016020 membrane GK2 GO:0016020 membrane SCN9A GO:0016020 membrane IFITM1 GO:0016020 membrane ATP1B1 GO:0016020 membrane PRM2 GO:0016020 membrane PTGES GO:0016020 membrane FXYD6 GO:0016020 membrane CDH17 GO:0016020 membrane CACNA1C GO:0016020 membrane MPZ GO:0016020 membrane SLC19A1 GO:0016020 membrane CLEC2 GO:0016020 membrane HSD3B1 GO:0016020 membrane ATP12A GO:0016020 membrane ANXA4 GO:0016020 membrane SLC17A1 GO:0016020 membrane MS4A2 GO:0016020 membrane RNF128 GO:0016020 membrane CALB2 GO:0016020 membrane SEMA6A GO:0016020 membrane GPR6 GO:0016020 membrane MSN GO:0016020 membrane FEN1 GO:0016020 membrane LRP10 GO:0016020 membrane ROR1 GO:0016020 membrane CCKBR GO:0016020 membrane SPAG5 GO:0016020 membrane GPC4 GO:0016020 membrane EGFL6 GO:0016020 membrane CYP26A1 GO:0016020 membrane STX6 GO:0016020 membrane HNRPM GO:0016020 membrane SIAT4C GO:0016020 membrane GPM6B GO:0016020 membrane RRAS2 GO:0016020 membrane OCA2 GO:0016020 membrane MID1 GO:0016020 membrane ELOVL4 GO:0016020 membrane ALPI GO:0016020 membrane HSD3B2 GO:0016020 membrane TLR8 GO:0016020 membrane SLC7A11 GO:0016020 membrane ITM2B GO:0016020 membrane LRIG1 GO:0016020 membrane CKB GO:0016020 membrane MGST1 GO:0016020 membrane CYP19A1 GO:0016020 membrane NRBP GO:0016020 membrane MGAT5 GO:0016020 membrane AP2B1 GO:0016020 membrane GRIN2D GO:0016020 membrane GPC5 GO:0016020 membrane GLIPR1 GO:0016020 membrane IFNGR2 GO:0016020 membrane FZD4 GO:0016020 membrane SEMA5B GO:0016020 membrane SLC19A2 GO:0016020 membrane ITGBL1 GO:0016020 membrane PRNP GO:0016020 membrane CLC GO:0016020 membrane SLCO4A1

84:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0016020 membrane CYP17A1 GO:0016020 membrane SEMA4C GO:0016020 membrane COPE GO:0016020 membrane COX7C GO:0016020 membrane PLSCR3 GO:0016020 membrane FAP GO:0016020 membrane ATP6V1E2 GO:0016020 membrane GGTLA1 GO:0016020 membrane TAPBP GO:0016020 membrane JAM2 GO:0016020 membrane TPST2 GO:0016020 membrane LY6E GO:0016020 membrane NRXN3 GO:0016020 membrane PLEKHA1 GO:0016020 membrane APM2 GO:0016020 membrane EPHA3 GO:0016020 membrane CADPS2 GO:0016020 membrane GNA11 GO:0016020 membrane SLC2A1 GO:0016020 membrane BRS3 GO:0016020 membrane GPC3 GO:0016020 membrane TNFRSF1A GO:0016020 membrane PRKAR2A GO:0016020 membrane PTGDS GO:0016020 membrane GPR45 GO:0016020 membrane LAMB2 GO:0016020 membrane SLCO2A1 GO:0016020 membrane SPRY1 GO:0016020 membrane SORL1 GO:0016020 membrane ADORA2B GO:0016020 membrane ACE2 GO:0016020 membrane EMP1 GO:0016020 membrane SCARB1 GO:0004179 membrane_alanyl_aminopeptidase_activity ENPEP GO:0004179 membrane_alanyl_aminopeptidase_activity RNPEP GO:0030117 membrane_coat AP2B1 GO:0030117 membrane_coat APM2 GO:0030117 membrane_coat CLC GO:0030119 membrane_coat_adaptor_complex AP2B1 GO:0030119 membrane_coat_adaptor_complex APM2 GO:0005624 membrane_fraction PTGES GO:0005624 membrane_fraction AMBP GO:0005624 membrane_fraction TAPBP GO:0005624 membrane_fraction FOLR1 GO:0005624 membrane_fraction DSCAM GO:0005624 membrane_fraction CYP26A1 GO:0005624 membrane_fraction CBR1 GO:0005624 membrane_fraction ITM2B GO:0005624 membrane_fraction HNRPM GO:0005624 membrane_fraction ZMPSTE24 GO:0005624 membrane_fraction APOB GO:0005624 membrane_fraction MGST1 GO:0046467 membrane_lipid_biosynthesis PRKAA1 GO:0046467 membrane_lipid_biosynthesis FEN1 GO:0046467 membrane_lipid_biosynthesis EKI1 GO:0046466 membrane_lipid_catabolism GALC GO:0006643 membrane_lipid_metabolism GALC GO:0006643 membrane_lipid_metabolism PRKAA1 GO:0006643 membrane_lipid_metabolism FEN1 GO:0006643 membrane_lipid_metabolism CCT2 GO:0006643 membrane_lipid_metabolism EKI1

85:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007613 memory CRH GO:0042698 menstrual_cycle AFP GO:0042698 menstrual_cycle INHA GO:0045340 mercury_ion_binding FN1 GO:0007498 mesoderm_development SOX14 GO:0007498 mesoderm_development EPHA3 GO:0007498 mesoderm_development POU5F1 GO:0001707 mesoderm_formation EPHA3 GO:0007509 mesoderm_migration EPHA3 GO:0048332 mesoderm_morphogenesis EPHA3 GO:0008152 metabolism INHA GO:0008152 metabolism PRKAR2B GO:0008152 metabolism NARS GO:0008152 metabolism TLE4 GO:0008152 metabolism H2AFY GO:0008152 metabolism STAR GO:0008152 metabolism GLA GO:0008152 metabolism GSTA1 GO:0008152 metabolism TBX3 GO:0008152 metabolism EKI1 GO:0008152 metabolism INDO GO:0008152 metabolism ATIC GO:0008152 metabolism MTA3 GO:0008152 metabolism HSD17B1 GO:0008152 metabolism FOLR1 GO:0008152 metabolism PGK1 GO:0008152 metabolism COX6A2 GO:0008152 metabolism ENPEP GO:0008152 metabolism PAX5 GO:0008152 metabolism SALL1 GO:0008152 metabolism CDK8 GO:0008152 metabolism RNPEP GO:0008152 metabolism POU5F1 GO:0008152 metabolism ASF1A GO:0008152 metabolism FZD7 GO:0008152 metabolism AHR GO:0008152 metabolism PARG GO:0008152 metabolism NUDT1 GO:0008152 metabolism BCAT1 GO:0008152 metabolism PLAT GO:0008152 metabolism PTPRK GO:0008152 metabolism CEBPD GO:0008152 metabolism AES GO:0008152 metabolism PCBD GO:0008152 metabolism CDH16 GO:0008152 metabolism DDX20 GO:0008152 metabolism H1F0 GO:0008152 metabolism PTPRR GO:0008152 metabolism VLDLR GO:0008152 metabolism HEY1 GO:0008152 metabolism ART3 GO:0008152 metabolism SIRT7 GO:0008152 metabolism DNMT3L GO:0008152 metabolism IDI1 GO:0008152 metabolism TESK2 GO:0008152 metabolism ACAS2L GO:0008152 metabolism NDUFB9 GO:0008152 metabolism APOE GO:0008152 metabolism ATBF1 GO:0008152 metabolism NQO1 GO:0008152 metabolism PRKAA1

86:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008152 metabolism UBA2 GO:0008152 metabolism GK2 GO:0008152 metabolism AASS GO:0008152 metabolism HEBP1 GO:0008152 metabolism TENR GO:0008152 metabolism KLF12 GO:0008152 metabolism BAG5 GO:0008152 metabolism TLX2 GO:0008152 metabolism DNMT3B GO:0008152 metabolism MLL GO:0008152 metabolism APEH GO:0008152 metabolism ETS2 GO:0008152 metabolism PTGES GO:0008152 metabolism CBFB GO:0008152 metabolism COL6A1 GO:0008152 metabolism HMGB2 GO:0008152 metabolism RPS8 GO:0008152 metabolism WARS GO:0008152 metabolism PPIC GO:0008152 metabolism HESX1 GO:0008152 metabolism PPP6C GO:0008152 metabolism ADAMTS19 GO:0008152 metabolism ZMPSTE24 GO:0008152 metabolism APOA2 GO:0008152 metabolism ARID3A GO:0008152 metabolism GGPS1 GO:0008152 metabolism HSD3B1 GO:0008152 metabolism ATP12A GO:0008152 metabolism HNF3B GO:0008152 metabolism ARNTL GO:0008152 metabolism RNF128 GO:0008152 metabolism GMPR2 GO:0008152 metabolism LDHA GO:0008152 metabolism F2 GO:0008152 metabolism LOXL1 GO:0008152 metabolism GLRX2 GO:0008152 metabolism FN1 GO:0008152 metabolism FOXA1 GO:0008152 metabolism MSN GO:0008152 metabolism FEN1 GO:0008152 metabolism LRP10 GO:0008152 metabolism HES7 GO:0008152 metabolism FHL2 GO:0008152 metabolism ROR1 GO:0008152 metabolism CBS GO:0008152 metabolism SPAG5 GO:0008152 metabolism CALB1 GO:0008152 metabolism DUSP6 GO:0008152 metabolism GSTP1 GO:0008152 metabolism RPL18A GO:0008152 metabolism EPAS1 GO:0008152 metabolism RPL28 GO:0008152 metabolism CYP26A1 GO:0008152 metabolism SIAT4C GO:0008152 metabolism SOX30 GO:0008152 metabolism GMPR GO:0008152 metabolism OCA2 GO:0008152 metabolism MID1 GO:0008152 metabolism ELOVL4 GO:0008152 metabolism ALPI GO:0008152 metabolism TRPS1

87:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008152 metabolism HSD3B2 GO:0008152 metabolism CBR1 GO:0008152 metabolism CKB GO:0008152 metabolism MGST1 GO:0008152 metabolism CYP19A1 GO:0008152 metabolism CASP7 GO:0008152 metabolism RPL29 GO:0008152 metabolism PPP1R12B GO:0008152 metabolism GLB1 GO:0008152 metabolism PAX3 GO:0008152 metabolism PTPN13 GO:0008152 metabolism TLE1 GO:0008152 metabolism TCF7L2 GO:0008152 metabolism NR2F1 GO:0008152 metabolism FEM1B GO:0008152 metabolism TBX2 GO:0008152 metabolism CITED1 GO:0008152 metabolism GNE GO:0008152 metabolism PAICS GO:0008152 metabolism SHOX2 GO:0008152 metabolism PRNP GO:0008152 metabolism ALDH1A3 GO:0008152 metabolism TTR GO:0008152 metabolism C1R GO:0008152 metabolism BHLHB3 GO:0008152 metabolism EMX2 GO:0008152 metabolism CCT2 GO:0008152 metabolism APOB GO:0008152 metabolism BAZ1B GO:0008152 metabolism GFPT2 GO:0008152 metabolism CYP17A1 GO:0008152 metabolism GALC GO:0008152 metabolism MMP11 GO:0008152 metabolism TCEA2 GO:0008152 metabolism GADD45A GO:0008152 metabolism SOX14 GO:0008152 metabolism UMPK GO:0008152 metabolism EIF3S5 GO:0008152 metabolism HS2ST1 GO:0008152 metabolism COX7C GO:0008152 metabolism GSTM3 GO:0008152 metabolism FAP GO:0008152 metabolism SSBP1 GO:0008152 metabolism ATP6V1E2 GO:0008152 metabolism AFP GO:0008152 metabolism GGTLA1 GO:0008152 metabolism TMLHE GO:0008152 metabolism MAPK4 GO:0008152 metabolism WISP2 GO:0008152 metabolism NAP1L1 GO:0008152 metabolism EPHA3 GO:0008152 metabolism MAP3K5 GO:0008152 metabolism NSEP1 GO:0008152 metabolism SUCLA2 GO:0008152 metabolism CKMT2 GO:0008152 metabolism GNA11 GO:0008152 metabolism HDLBP GO:0008152 metabolism CBR3 GO:0008152 metabolism AR GO:0008152 metabolism TK1 GO:0008152 metabolism AMPD2

88:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008152 metabolism TNFRSF1A GO:0008152 metabolism PRKAR2A GO:0008152 metabolism TBPL1 GO:0008152 metabolism PTGDS GO:0008152 metabolism BAP1 GO:0008152 metabolism HSPA1A GO:0008152 metabolism LAMB2 GO:0008152 metabolism SORL1 GO:0008152 metabolism TCF8 GO:0008152 metabolism ACE2 GO:0008152 metabolism UPP1 GO:0008152 metabolism NFIA GO:0046872 metal_ion_binding CALB1 GO:0046872 metal_ion_binding ANXA9 GO:0046872 metal_ion_binding MID1 GO:0046872 metal_ion_binding ALPI GO:0046872 metal_ion_binding TRPS1 GO:0046872 metal_ion_binding ENPEP GO:0046872 metal_ion_binding SALL1 GO:0046872 metal_ion_binding RNPEP GO:0046872 metal_ion_binding TNA GO:0046872 metal_ion_binding CAPNS1 GO:0046872 metal_ion_binding GRIN2D GO:0046872 metal_ion_binding CDH16 GO:0046872 metal_ion_binding PLS3 GO:0046872 metal_ion_binding MT1A GO:0046872 metal_ion_binding VLDLR GO:0046872 metal_ion_binding IDI1 GO:0046872 metal_ion_binding CETN3 GO:0046872 metal_ion_binding PRNP GO:0046872 metal_ion_binding NCALD GO:0046872 metal_ion_binding MT2A GO:0046872 metal_ion_binding ATBF1 GO:0046872 metal_ion_binding MMP11 GO:0046872 metal_ion_binding S100A11 GO:0046872 metal_ion_binding THBS2 GO:0046872 metal_ion_binding PLSCR3 GO:0046872 metal_ion_binding KLF12 GO:0046872 metal_ion_binding PRND GO:0046872 metal_ion_binding MLL GO:0046872 metal_ion_binding AFP GO:0046872 metal_ion_binding CDH17 GO:0046872 metal_ion_binding WISP2 GO:0046872 metal_ion_binding CACNA1C GO:0046872 metal_ion_binding ADAMTS19 GO:0046872 metal_ion_binding PPP6C GO:0046872 metal_ion_binding ATP12A GO:0046872 metal_ion_binding ANXA4 GO:0046872 metal_ion_binding VSNL1 GO:0046872 metal_ion_binding CALB2 GO:0046872 metal_ion_binding TRAF5 GO:0046872 metal_ion_binding F2 GO:0046872 metal_ion_binding CALN1 GO:0046872 metal_ion_binding LOXL1 GO:0046872 metal_ion_binding FN1 GO:0046872 metal_ion_binding LAMB2 GO:0046872 metal_ion_binding FEN1 GO:0046872 metal_ion_binding SORL1 GO:0046872 metal_ion_binding ANXA3 GO:0046872 metal_ion_binding TCF8 GO:0046872 metal_ion_binding FBLN1

89:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0046872 metal_ion_binding CBS GO:0006875 metal_ion_homeostasis PRNP GO:0006875 metal_ion_homeostasis MT2A GO:0006875 metal_ion_homeostasis PRND GO:0006875 metal_ion_homeostasis MT1A GO:0030001 metal_ion_transport ATP12A GO:0030001 metal_ion_transport MID1 GO:0030001 metal_ion_transport SLC17A1 GO:0030001 metal_ion_transport CACNA1C GO:0030001 metal_ion_transport SCN9A GO:0030001 metal_ion_transport ATP1B1 GO:0046873 metal_ion_transporter_activity NDUFB9 GO:0004222 metalloendopeptidase_activity MMP11 GO:0004222 metalloendopeptidase_activity ADAMTS19 GO:0004222 metalloendopeptidase_activity ZMPSTE24 GO:0008191 metalloendopeptidase_inhibitor_activity TIMP4 GO:0008235 metalloexopeptidase_activity ENPEP GO:0008235 metalloexopeptidase_activity RNPEP GO:0008237 metallopeptidase_activity SPAG5 GO:0008237 metallopeptidase_activity MMP11 GO:0008237 metallopeptidase_activity ENPEP GO:0008237 metallopeptidase_activity ADAMTS19 GO:0008237 metallopeptidase_activity ACE2 GO:0008237 metallopeptidase_activity ZMPSTE24 GO:0008237 metallopeptidase_activity RNPEP GO:0008168 methyltransferase_activity ATIC GO:0008168 methyltransferase_activity WBSCR22 GO:0008168 methyltransferase_activity DNMT3B GO:0042287 MHC_protein_binding IL27RA GO:0042579 microbody IDI1 GO:0001527 microfibril MFAP4 GO:0005792 microsome PTGES GO:0005792 microsome AMBP GO:0005792 microsome TAPBP GO:0005792 microsome CYP26A1 GO:0005792 microsome CBR1 GO:0005792 microsome APOB GO:0005792 microsome MGST1 GO:0005874 microtubule SPAG5 GO:0005875 microtubule_associated_complex MYH11 GO:0005875 microtubule_associated_complex STMN1 GO:0005875 microtubule_associated_complex MID1 GO:0005875 microtubule_associated_complex LAMB2 GO:0005875 microtubule_associated_complex STX6 GO:0005875 microtubule_associated_complex DNCL2A GO:0005875 microtubule_associated_complex SYCP2 GO:0008017 microtubule_binding SPAG5 GO:0015630 microtubule_cytoskeleton MYH11 GO:0015630 microtubule_cytoskeleton STMN1 GO:0015630 microtubule_cytoskeleton SPAG5 GO:0015630 microtubule_cytoskeleton MID1 GO:0015630 microtubule_cytoskeleton CETN3 GO:0015630 microtubule_cytoskeleton LAMB2 GO:0015630 microtubule_cytoskeleton H2AFY GO:0015630 microtubule_cytoskeleton CKAP1 GO:0015630 microtubule_cytoskeleton DNCL2A GO:0015630 microtubule_cytoskeleton STX6 GO:0015630 microtubule_cytoskeleton CCT2 GO:0015630 microtubule_cytoskeleton SYCP2 GO:0000226 microtubule_cytoskeleton_organization_and_biogenesis STMN1 GO:0000226 microtubule_cytoskeleton_organization_and_biogenesis CCT2

90:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007019 microtubule_depolymerization STMN1 GO:0007020 microtubule_nucleation CCT2 GO:0005815 microtubule_organizing_center CETN3 GO:0005815 microtubule_organizing_center H2AFY GO:0005815 microtubule_organizing_center CCT2 GO:0007018 microtubule-based_movement DNCL2A GO:0007017 microtubule-based_process STMN1 GO:0007017 microtubule-based_process CKAP1 GO:0007017 microtubule-based_process DNCL2A GO:0007017 microtubule-based_process CCT2 GO:0006120 mitochondrial_electron_transport,_NADH_to_ubiquinone NDUFB9 GO:0005746 mitochondrial_electron_transport_chain COX6A2 GO:0005746 mitochondrial_electron_transport_chain COX7C GO:0005743 mitochondrial_inner_membrane NDUFB9 GO:0005743 mitochondrial_inner_membrane COX6A2 GO:0005743 mitochondrial_inner_membrane COX7C GO:0005743 mitochondrial_inner_membrane ATP6V1E2 GO:0005759 mitochondrial_matrix ACAS2L GO:0005740 mitochondrial_membrane GK2 GO:0005740 mitochondrial_membrane NDUFB9 GO:0005740 mitochondrial_membrane COX6A2 GO:0005740 mitochondrial_membrane COX7C GO:0005740 mitochondrial_membrane ROPN1 GO:0005740 mitochondrial_membrane ATP6V1E2 GO:0005741 mitochondrial_outer_membrane GK2 GO:0005741 mitochondrial_outer_membrane ROPN1 GO:0005739 mitochondrion CYP17A1 GO:0005739 mitochondrion SUCLA2 GO:0005739 mitochondrion CKMT2 GO:0005739 mitochondrion GK2 GO:0005739 mitochondrion AASS GO:0005739 mitochondrion HEBP1 GO:0005739 mitochondrion STAR GO:0005739 mitochondrion COX7C GO:0005739 mitochondrion TK1 GO:0005739 mitochondrion SSBP1 GO:0005739 mitochondrion ATP6V1E2 GO:0005739 mitochondrion HCCS GO:0005739 mitochondrion TMLHE GO:0005739 mitochondrion ACAS2L GO:0005739 mitochondrion NDUFB9 GO:0005739 mitochondrion COX6A2 GO:0005739 mitochondrion HSD3B2 GO:0005739 mitochondrion CKB GO:0005739 mitochondrion ROPN1 GO:0005739 mitochondrion MGST1 GO:0005739 mitochondrion HSD3B1 GO:0007067 mitosis TERF1 GO:0007067 mitosis SPAG5 GO:0007067 mitosis STMN1 GO:0007067 mitosis CETN3 GO:0007067 mitosis CDK8 GO:0007067 mitosis PRM2 GO:0000278 mitotic_cell_cycle TERF1 GO:0000278 mitotic_cell_cycle SPAG5 GO:0000278 mitotic_cell_cycle STMN1 GO:0000278 mitotic_cell_cycle CETN3 GO:0000278 mitotic_cell_cycle GADD45A GO:0000278 mitotic_cell_cycle PPP6C GO:0000278 mitotic_cell_cycle ID2 GO:0000278 mitotic_cell_cycle ACE2

91:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0000278 mitotic_cell_cycle CDK8 GO:0000278 mitotic_cell_cycle PRM2 GO:0007076 mitotic_chromosome_condensation PRM2 GO:0000088 mitotic_prophase PRM2 GO:0007052 mitotic_spindle_assembly STMN1 GO:0019941 modification-dependent_protein_catabolism UBA2 GO:0019941 modification-dependent_protein_catabolism BAP1 GO:0003674 molecular_function PRKAR2B GO:0003674 molecular_function INHA GO:0003674 molecular_function TLE4 GO:0003674 molecular_function CLIC6 GO:0003674 molecular_function GSTA1 GO:0003674 molecular_function STAR GO:0003674 molecular_function PAPLN GO:0003674 molecular_function MGST2 GO:0003674 molecular_function SPA17 GO:0003674 molecular_function MTA3 GO:0003674 molecular_function HSD17B1 GO:0003674 molecular_function ENPEP GO:0003674 molecular_function SLC2A3 GO:0003674 molecular_function PAX5 GO:0003674 molecular_function NUDT11 GO:0003674 molecular_function WBSCR22 GO:0003674 molecular_function CPR8 GO:0003674 molecular_function FZD7 GO:0003674 molecular_function AHR GO:0003674 molecular_function PARG GO:0003674 molecular_function PLAT GO:0003674 molecular_function BCAT1 GO:0003674 molecular_function PTPRK GO:0003674 molecular_function ANGPTL1 GO:0003674 molecular_function AES GO:0003674 molecular_function PLS3 GO:0003674 molecular_function DDX20 GO:0003674 molecular_function PTPRR GO:0003674 molecular_function VLDLR GO:0003674 molecular_function ART3 GO:0003674 molecular_function DNMT3L GO:0003674 molecular_function SIRT7 GO:0003674 molecular_function ACAS2L GO:0003674 molecular_function NDUFB9 GO:0003674 molecular_function CART GO:0003674 molecular_function APOE GO:0003674 molecular_function NCALD GO:0003674 molecular_function DNCL2A GO:0003674 molecular_function CX3CL1 GO:0003674 molecular_function PRKAA1 GO:0003674 molecular_function GK2 GO:0003674 molecular_function HEBP1 GO:0003674 molecular_function THBS2 GO:0003674 molecular_function SCN9A GO:0003674 molecular_function KLF12 GO:0003674 molecular_function BAG5 GO:0003674 molecular_function TLX2 GO:0003674 molecular_function MLL GO:0003674 molecular_function APEH GO:0003674 molecular_function PTGES GO:0003674 molecular_function FXYD6 GO:0003674 molecular_function CDH17 GO:0003674 molecular_function SRGAP2 GO:0003674 molecular_function RPS8

92:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0003674 molecular_function WARS GO:0003674 molecular_function TBC1D1 GO:0003674 molecular_function HESX1 GO:0003674 molecular_function PPP6C GO:0003674 molecular_function CACNA1C GO:0003674 molecular_function MPZ GO:0003674 molecular_function CLEC2 GO:0003674 molecular_function GGPS1 GO:0003674 molecular_function TERF1 GO:0003674 molecular_function MYH11 GO:0003674 molecular_function YBX2 GO:0003674 molecular_function RBPMS GO:0003674 molecular_function ANXA4 GO:0003674 molecular_function MS4A2 GO:0003674 molecular_function COL1A2 GO:0003674 molecular_function HNF3B GO:0003674 molecular_function DHRS10 GO:0003674 molecular_function CALB2 GO:0003674 molecular_function GMPR2 GO:0003674 molecular_function CRYAB GO:0003674 molecular_function AMBP GO:0003674 molecular_function LDHA GO:0003674 molecular_function OPLAH GO:0003674 molecular_function NUDT10 GO:0003674 molecular_function FN1 GO:0003674 molecular_function FOXA1 GO:0003674 molecular_function HES7 GO:0003674 molecular_function COL14A1 GO:0003674 molecular_function ROR1 GO:0003674 molecular_function IGF1 GO:0003674 molecular_function SPAG5 GO:0003674 molecular_function GPC4 GO:0003674 molecular_function DUSP6 GO:0003674 molecular_function CALB1 GO:0003674 molecular_function GSTP1 GO:0003674 molecular_function RPL18A GO:0003674 molecular_function CYP26A1 GO:0003674 molecular_function RPL28 GO:0003674 molecular_function JARID2 GO:0003674 molecular_function STX6 GO:0003674 molecular_function HNRPM GO:0003674 molecular_function HDGF GO:0003674 molecular_function GAL GO:0003674 molecular_function RRAS2 GO:0003674 molecular_function SOX30 GO:0003674 molecular_function OCA2 GO:0003674 molecular_function MID1 GO:0003674 molecular_function TRPS1 GO:0003674 molecular_function ALPI GO:0003674 molecular_function LYAR GO:0003674 molecular_function TLR8 GO:0003674 molecular_function CBR1 GO:0003674 molecular_function PDZK1 GO:0003674 molecular_function CYP19A1 GO:0003674 molecular_function CASP7 GO:0003674 molecular_function AP2B1 GO:0003674 molecular_function PPP1R12B GO:0003674 molecular_function GLB1 GO:0003674 molecular_function SEMA5B GO:0003674 molecular_function PTPN13 GO:0003674 molecular_function CAPZB

93:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0003674 molecular_function GNB2L1 GO:0003674 molecular_function NR2F1 GO:0003674 molecular_function FEM1B GO:0003674 molecular_function SLC19A2 GO:0003674 molecular_function ITGBL1 GO:0003674 molecular_function LGALS8 GO:0003674 molecular_function CUL1 GO:0003674 molecular_function GNE GO:0003674 molecular_function PRNP GO:0003674 molecular_function SHOX2 GO:0003674 molecular_function CCT2 GO:0003674 molecular_function DHX35 GO:0003674 molecular_function BAZ1B GO:0003674 molecular_function GFPT2 GO:0003674 molecular_function CYP17A1 GO:0003674 molecular_function COPE GO:0003674 molecular_function CHRDL2 GO:0003674 molecular_function GADD45A GO:0003674 molecular_function ARL4 GO:0003674 molecular_function UMPK GO:0003674 molecular_function SOX14 GO:0003674 molecular_function HS2ST1 GO:0003674 molecular_function EIF3S5 GO:0003674 molecular_function BIRC3 GO:0003674 molecular_function FAP GO:0003674 molecular_function AFP GO:0003674 molecular_function TMLHE GO:0003674 molecular_function TAPBP GO:0003674 molecular_function ARHGAP4 GO:0003674 molecular_function TPST2 GO:0003674 molecular_function WISP2 GO:0003674 molecular_function NAP1L1 GO:0003674 molecular_function APM2 GO:0003674 molecular_function EPHA3 GO:0003674 molecular_function MAP3K5 GO:0003674 molecular_function CKMT2 GO:0003674 molecular_function BMP2 GO:0003674 molecular_function GNA11 GO:0003674 molecular_function VSNL1 GO:0003674 molecular_function GNAI1 GO:0003674 molecular_function CBR3 GO:0003674 molecular_function TIP120B GO:0003674 molecular_function TK1 GO:0003674 molecular_function BRS3 GO:0003674 molecular_function AMPD2 GO:0003674 molecular_function TNFRSF1A GO:0003674 molecular_function MCF2 GO:0003674 molecular_function PRKAR2A GO:0003674 molecular_function PTGDS GO:0003674 molecular_function COL16A1 GO:0003674 molecular_function DDX25 GO:0003674 molecular_function HSPA1A GO:0003674 molecular_function TCF8 GO:0003674 molecular_function ANXA3 GO:0003674 molecular_function SCARB1 GO:0003674 molecular_function NFIA GO:0003674 molecular_function NARS GO:0003674 molecular_function DSCAM GO:0003674 molecular_function PTGER3 GO:0003674 molecular_function GLA GO:0003674 molecular_function H2AFY

94:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0003674 molecular_function TPD52L1 GO:0003674 molecular_function TBX3 GO:0003674 molecular_function ANXA9 GO:0003674 molecular_function DRG1 GO:0003674 molecular_function EKI1 GO:0003674 molecular_function CRH GO:0003674 molecular_function HCCS GO:0003674 molecular_function INDO GO:0003674 molecular_function APPBP1 GO:0003674 molecular_function ATIC GO:0003674 molecular_function PGK1 GO:0003674 molecular_function FOLR1 GO:0003674 molecular_function COX6A2 GO:0003674 molecular_function SALL1 GO:0003674 molecular_function ROPN1 GO:0003674 molecular_function RNPEP GO:0003674 molecular_function CDK8 GO:0003674 molecular_function CDKN3 GO:0003674 molecular_function POU5F1 GO:0003674 molecular_function ASF1A GO:0003674 molecular_function PTPRD GO:0003674 molecular_function NUDT1 GO:0003674 molecular_function ARPC1A GO:0003674 molecular_function BAMBI GO:0003674 molecular_function CEBPD GO:0003674 molecular_function CDH16 GO:0003674 molecular_function PCBD GO:0003674 molecular_function CKAP1 GO:0003674 molecular_function PRH1 GO:0003674 molecular_function MT1A GO:0003674 molecular_function H1F0 GO:0003674 molecular_function HEY1 GO:0003674 molecular_function IDI1 GO:0003674 molecular_function TESK2 GO:0003674 molecular_function TIMP4 GO:0003674 molecular_function ATBF1 GO:0003674 molecular_function SERPINC1 GO:0003674 molecular_function COL4A5 GO:0003674 molecular_function NQO1 GO:0003674 molecular_function COL6A2 GO:0003674 molecular_function UBA2 GO:0003674 molecular_function VTN GO:0003674 molecular_function AASS GO:0003674 molecular_function TENR GO:0003674 molecular_function COL5A2 GO:0003674 molecular_function PWP1 GO:0003674 molecular_function ATP1B1 GO:0003674 molecular_function PRND GO:0003674 molecular_function DNMT3B GO:0003674 molecular_function PRM2 GO:0003674 molecular_function ETS2 GO:0003674 molecular_function CAPZA3 GO:0003674 molecular_function CILP GO:0003674 molecular_function GSTA2 GO:0003674 molecular_function FABP5 GO:0003674 molecular_function CDC42EP4 GO:0003674 molecular_function CBFB GO:0003674 molecular_function COL6A1 GO:0003674 molecular_function HMGB2 GO:0003674 molecular_function PPIC GO:0003674 molecular_function ADAMTS19

95:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0003674 molecular_function ZMPSTE24 GO:0003674 molecular_function SLC19A1 GO:0003674 molecular_function GDF10 GO:0003674 molecular_function APOA2 GO:0003674 molecular_function SULT1E1 GO:0003674 molecular_function NANOG GO:0003674 molecular_function ARID3A GO:0003674 molecular_function HSD3B1 GO:0003674 molecular_function PAP GO:0003674 molecular_function AGTRAP GO:0003674 molecular_function ATP12A GO:0003674 molecular_function TGFBI GO:0003674 molecular_function SLC17A1 GO:0003674 molecular_function COL4A6 GO:0003674 molecular_function ARNTL GO:0003674 molecular_function RNF128 GO:0003674 molecular_function GPR6 GO:0003674 molecular_function F2 GO:0003674 molecular_function LOXL1 GO:0003674 molecular_function CALN1 GO:0003674 molecular_function MSN GO:0003674 molecular_function FEN1 GO:0003674 molecular_function CGA GO:0003674 molecular_function LRP10 GO:0003674 molecular_function FHL2 GO:0003674 molecular_function CBS GO:0003674 molecular_function CCKBR GO:0003674 molecular_function EPAS1 GO:0003674 molecular_function SIAT4C GO:0003674 molecular_function GMPR GO:0003674 molecular_function SYCP2 GO:0003674 molecular_function IL27RA GO:0003674 molecular_function HSD3B2 GO:0003674 molecular_function SLC7A11 GO:0003674 molecular_function ITM2B GO:0003674 molecular_function CKB GO:0003674 molecular_function MGST1 GO:0003674 molecular_function EPPK1 GO:0003674 molecular_function TNA GO:0003674 molecular_function NRBP GO:0003674 molecular_function RPL29 GO:0003674 molecular_function MGAT5 GO:0003674 molecular_function CAPNS1 GO:0003674 molecular_function ZFP36L2 GO:0003674 molecular_function GRIN2D GO:0003674 molecular_function NOL6 GO:0003674 molecular_function PAX3 GO:0003674 molecular_function FZD4 GO:0003674 molecular_function IFNGR2 GO:0003674 molecular_function PROSC GO:0003674 molecular_function TCF7L2 GO:0003674 molecular_function TLE1 GO:0003674 molecular_function GRB14 GO:0003674 molecular_function TBX2 GO:0003674 molecular_function CITED1 GO:0003674 molecular_function PAICS GO:0003674 molecular_function CETN3 GO:0003674 molecular_function ALDH1A3 GO:0003674 molecular_function TTR GO:0003674 molecular_function C1R GO:0003674 molecular_function MT2A

96:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0003674 molecular_function BHLHB3 GO:0003674 molecular_function EMX2 GO:0003674 molecular_function COL1A1 GO:0003674 molecular_function CLC GO:0003674 molecular_function SLCO4A1 GO:0003674 molecular_function CIRBP GO:0003674 molecular_function DKK1 GO:0003674 molecular_function SEMA4C GO:0003674 molecular_function GALC GO:0003674 molecular_function MMP11 GO:0003674 molecular_function S100A11 GO:0003674 molecular_function TCEA2 GO:0003674 molecular_function MKRN1 GO:0003674 molecular_function TNNT3 GO:0003674 molecular_function COX7C GO:0003674 molecular_function PLSCR3 GO:0003674 molecular_function ARMC4 GO:0003674 molecular_function GSTM3 GO:0003674 molecular_function ATP6V1E2 GO:0003674 molecular_function SSBP1 GO:0003674 molecular_function GGTLA1 GO:0003674 molecular_function MAPK4 GO:0003674 molecular_function IL22RA1 GO:0003674 molecular_function PLEKHA1 GO:0003674 molecular_function ID2 GO:0003674 molecular_function CADPS2 GO:0003674 molecular_function NSEP1 GO:0003674 molecular_function SUCLA2 GO:0003674 molecular_function LIN28 GO:0003674 molecular_function SLC2A1 GO:0003674 molecular_function HDLBP GO:0003674 molecular_function AHSA1 GO:0003674 molecular_function KHDRBS3 GO:0003674 molecular_function AR GO:0003674 molecular_function SEMA6D GO:0003674 molecular_function OGN GO:0003674 molecular_function TBPL1 GO:0003674 molecular_function ELN GO:0003674 molecular_function GDF3 GO:0003674 molecular_function TRAF5 GO:0003674 molecular_function INSL3 GO:0003674 molecular_function STMN1 GO:0003674 molecular_function GPR45 GO:0003674 molecular_function ZFP36L1 GO:0003674 molecular_function BAP1 GO:0003674 molecular_function SLCO2A1 GO:0003674 molecular_function LAMB2 GO:0003674 molecular_function ADORA2B GO:0003674 molecular_function SORL1 GO:0003674 molecular_function ACE2 GO:0003674 molecular_function MDK GO:0003674 molecular_function UPP1 GO:0003674 molecular_function FBLN1 GO:0005554 molecular_function_unknown LIN28 GO:0005554 molecular_function_unknown BAMBI GO:0005554 molecular_function_unknown TLE4 GO:0005554 molecular_function_unknown NOL6 GO:0005554 molecular_function_unknown TBX3 GO:0005554 molecular_function_unknown PWP1 GO:0005554 molecular_function_unknown SEMA6D GO:0005554 molecular_function_unknown ARMC4

97:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005554 molecular_function_unknown PRM2 GO:0005554 molecular_function_unknown SSBP1 GO:0005554 molecular_function_unknown CILP GO:0005554 molecular_function_unknown MTA3 GO:0005554 molecular_function_unknown TAPBP GO:0005554 molecular_function_unknown ARHGAP4 GO:0005554 molecular_function_unknown DNCL2A GO:0005554 molecular_function_unknown SALL1 GO:0005554 molecular_function_unknown SLCO4A1 GO:0005554 molecular_function_unknown MAP3K5 GO:0015256 monocarboxylate_channel_activity GRIN2D GO:0015718 monocarboxylic_acid_transport SLCO2A1 GO:0008028 monocarboxylic_acid_transporter_activity SLCO2A1 GO:0030224 monocyte_differentiation INHA GO:0030224 monocyte_differentiation GMPR2 GO:0004497 monooxygenase_activity CYP17A1 GO:0004497 monooxygenase_activity CYP26A1 GO:0004497 monooxygenase_activity CYP19A1 GO:0046364 monosaccharide_biosynthesis PRKAA1 GO:0046364 monosaccharide_biosynthesis PGK1 GO:0046365 monosaccharide_catabolism LDHA GO:0046365 monosaccharide_catabolism SUCLA2 GO:0046365 monosaccharide_catabolism PGK1 GO:0046365 monosaccharide_catabolism PARG GO:0005996 monosaccharide_metabolism SUCLA2 GO:0005996 monosaccharide_metabolism LDHA GO:0005996 monosaccharide_metabolism PRKAA1 GO:0005996 monosaccharide_metabolism PARG GO:0005996 monosaccharide_metabolism PGK1 GO:0015749 monosaccharide_transport PRKAA1 GO:0015145 monosaccharide_transporter_activity SLC2A1 GO:0015145 monosaccharide_transporter_activity SLC2A3 GO:0015672 monovalent_inorganic_cation_transport ATP12A GO:0015672 monovalent_inorganic_cation_transport SLC17A1 GO:0015672 monovalent_inorganic_cation_transport SCN9A GO:0015672 monovalent_inorganic_cation_transport ATP1B1 GO:0015672 monovalent_inorganic_cation_transport ATP6V1E2 GO:0015077 monovalent_inorganic_cation_transporter_activity ATP12A GO:0015077 monovalent_inorganic_cation_transporter_activity NDUFB9 GO:0015077 monovalent_inorganic_cation_transporter_activity COX6A2 GO:0015077 monovalent_inorganic_cation_transporter_activity COX7C GO:0015077 monovalent_inorganic_cation_transporter_activity ATP6V1E2 GO:0009653 morphogenesis INHA GO:0009653 morphogenesis PRKAR2B GO:0009653 morphogenesis DSCAM GO:0009653 morphogenesis EPAS1 GO:0009653 morphogenesis GAL GO:0009653 morphogenesis CKB GO:0009653 morphogenesis SALL1 GO:0009653 morphogenesis PAX5 GO:0009653 morphogenesis TNA GO:0009653 morphogenesis LST1 GO:0009653 morphogenesis POU5F1 GO:0009653 morphogenesis ARPC1A GO:0009653 morphogenesis PAX3 GO:0009653 morphogenesis AES GO:0009653 morphogenesis DDX20 GO:0009653 morphogenesis SEMA5B GO:0009653 morphogenesis NR2F1 GO:0009653 morphogenesis CUL1 GO:0009653 morphogenesis BHLHB3

98:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0009653 morphogenesis EMX2 GO:0009653 morphogenesis PMP22 GO:0009653 morphogenesis COL1A1 GO:0009653 morphogenesis DKK1 GO:0009653 morphogenesis SEMA4C GO:0009653 morphogenesis SOX14 GO:0009653 morphogenesis SEMA3E GO:0009653 morphogenesis TNNT3 GO:0009653 morphogenesis TAGLN GO:0009653 morphogenesis AFP GO:0009653 morphogenesis CDC42EP4 GO:0009653 morphogenesis CBFB GO:0009653 morphogenesis WISP2 GO:0009653 morphogenesis HMGB2 GO:0009653 morphogenesis HESX1 GO:0009653 morphogenesis PPP6C GO:0009653 morphogenesis GDF10 GO:0009653 morphogenesis EPHA3 GO:0009653 morphogenesis MYH11 GO:0009653 morphogenesis GNA11 GO:0009653 morphogenesis BMP2 GO:0009653 morphogenesis ANXA4 GO:0009653 morphogenesis AR GO:0009653 morphogenesis GPC3 GO:0009653 morphogenesis TNFRSF1A GO:0009653 morphogenesis GMPR2 GO:0009653 morphogenesis MCF2 GO:0009653 morphogenesis SEMA6A GO:0009653 morphogenesis ELN GO:0009653 morphogenesis CRYAB GO:0009653 morphogenesis INSL3 GO:0009653 morphogenesis STMN1 GO:0009653 morphogenesis MSN GO:0009653 morphogenesis ADORA2B GO:0009653 morphogenesis EMP1 GO:0009653 morphogenesis FBLN1 GO:0009653 morphogenesis IGF1 GO:0001738 morphogenesis_of_a_polarized_epithelium MSN GO:0002009 morphogenesis_of_an_epithelium MSN GO:0002009 morphogenesis_of_an_epithelium POU5F1 GO:0016331 morphogenesis_of_embryonic_epithelium MSN GO:0016331 morphogenesis_of_embryonic_epithelium POU5F1 GO:0003774 motor_activity MYH11 GO:0003729 mRNA_binding YBX2 GO:0016071 mRNA_metabolism DDX20 GO:0006397 mRNA_processing DDX20 GO:0006936 muscle_contraction MYH11 GO:0006936 muscle_contraction TNNT3 GO:0007517 muscle_development MYH11 GO:0007517 muscle_development TAGLN GO:0007517 muscle_development TNNT3 GO:0007517 muscle_development ELN GO:0030484 muscle_fiber MYH11 GO:0030484 muscle_fiber CKMT2 GO:0030484 muscle_fiber TNNT3 GO:0005859 muscle_myosin MYH11 GO:0050881 musculoskeletal_movement NR2F1 GO:0042552 myelination PMP22 GO:0030099 myeloid_blood_cell_differentiation CBFB GO:0030099 myeloid_blood_cell_differentiation INHA GO:0030099 myeloid_blood_cell_differentiation GMPR2

99:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0030016 myofibril MYH11 GO:0030016 myofibril CKMT2 GO:0030016 myofibril TNNT3 GO:0007519 myogenesis ELN GO:0016459 myosin MYH11 GO:0016460 myosin_II MYH11 GO:0017018 myosin_phosphatase_activity DUSP6 GO:0017018 myosin_phosphatase_activity PPP6C GO:0006044 N-acetylglucosamine_metabolism GNE GO:0006054 N-acetylneuraminate_metabolism GNE GO:0003956 NAD(P)+-arginine_ADP-ribosyltransferase_activity ART3 GO:0003955 NAD(P)H_dehydrogenase_(quinone)_activity NQO1 GO:0008137 NADH_dehydrogenase_(ubiquinone)_activity NDUFB9 GO:0003954 NADH_dehydrogenase_activity NDUFB9 GO:0043066 negative_regulation_of_apoptosis PRKAA1 GO:0043066 negative_regulation_of_apoptosis BIRC3 GO:0043066 negative_regulation_of_apoptosis IGF1 GO:0045578 negative_regulation_of_B-cell_differentiation INHA GO:0009890 negative_regulation_of_biosynthesis PRKAA1 GO:0009890 negative_regulation_of_biosynthesis INHA GO:0009890 negative_regulation_of_biosynthesis RNF128 GO:0030195 negative_regulation_of_blood_coagulation TM4SF3 GO:0030514 negative_regulation_of_BMP_signaling_pathway BAMBI GO:0030514 negative_regulation_of_BMP_signaling_pathway CHRDL2 GO:0045786 negative_regulation_of_cell_cycle INHA GO:0045596 negative_regulation_of_cell_differentiation INHA GO:0008285 negative_regulation_of_cell_proliferation BAP1 GO:0008285 negative_regulation_of_cell_proliferation WISP2 GO:0008285 negative_regulation_of_cell_proliferation SCAP2 GO:0008285 negative_regulation_of_cell_proliferation GAL GO:0050819 negative_regulation_of_coagulation TM4SF3 GO:0042036 negative_regulation_of_cytokine_biosynthesis INHA GO:0042036 negative_regulation_of_cytokine_biosynthesis RNF128 GO:0001818 negative_regulation_of_cytokine_production INHA GO:0001818 negative_regulation_of_cytokine_production RNF128 GO:0043086 negative_regulation_of_enzyme_activity GADD45A GO:0046882 negative_regulation_of_follicle-stimulating_hormone_secretion INHA GO:0045814 negative_regulation_of_gene_expression,_epigenetic SIRT7 GO:0046318 negative_regulation_of_glucosylceramide_biosynthesis PRKAA1 GO:0045926 negative_regulation_of_growth GPC3 GO:0046888 negative_regulation_of_hormone_secretion INHA GO:0045077 negative_regulation_of_interferon-gamma_biosynthesis INHA GO:0051055 negative_regulation_of_lipid_biosynthesis PRKAA1 GO:0045620 negative_regulation_of_lymphocyte_differentiation INHA GO:0050672 negative_regulation_of_lymphocyte_proliferation GAL GO:0045650 negative_regulation_of_macrophage_differentiation INHA GO:0009892 negative_regulation_of_metabolism SIRT7 GO:0009892 negative_regulation_of_metabolism PRKAA1 GO:0009892 negative_regulation_of_metabolism INHA GO:0009892 negative_regulation_of_metabolism TBX2 GO:0009892 negative_regulation_of_metabolism TLE4 GO:0009892 negative_regulation_of_metabolism RNF128 GO:0009892 negative_regulation_of_metabolism AES GO:0009892 negative_regulation_of_metabolism BHLHB3 GO:0009892 negative_regulation_of_metabolism HES7 GO:0009892 negative_regulation_of_metabolism DDX20 GO:0009892 negative_regulation_of_metabolism TLE1 GO:0045656 negative_regulation_of_monocyte_differentiation INHA GO:0045638 negative_regulation_of_myeloid_blood_cell_differentiation INHA GO:0045934 negative_regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_mSIRT7 GO:0045934 negative_regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_mTBX2

100:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0045934 negative_regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_mTLE4 GO:0045934 negative_regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_mBHLHB3 GO:0045934 negative_regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_mAES GO:0045934 negative_regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_mDDX20 GO:0045934 negative_regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_mHES7 GO:0045934 negative_regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_mTLE1 GO:0045936 negative_regulation_of_phosphate_metabolism INHA GO:0042326 negative_regulation_of_phosphorylation INHA GO:0043118 negative_regulation_of_physiological_process INHA GO:0043118 negative_regulation_of_physiological_process TM4SF3 GO:0043069 negative_regulation_of_programmed_cell_death PRKAA1 GO:0043069 negative_regulation_of_programmed_cell_death BIRC3 GO:0043069 negative_regulation_of_programmed_cell_death IGF1 GO:0017148 negative_regulation_of_protein_biosynthesis PRKAA1 GO:0017148 negative_regulation_of_protein_biosynthesis INHA GO:0017148 negative_regulation_of_protein_biosynthesis RNF128 GO:0006469 negative_regulation_of_protein_kinase_activity GADD45A GO:0051048 negative_regulation_of_secretion INHA GO:0009968 negative_regulation_of_signal_transduction BAMBI GO:0009968 negative_regulation_of_signal_transduction CHRDL2 GO:0009968 negative_regulation_of_signal_transduction DKK1 GO:0016481 negative_regulation_of_transcription SIRT7 GO:0016481 negative_regulation_of_transcription TBX2 GO:0016481 negative_regulation_of_transcription TLE4 GO:0016481 negative_regulation_of_transcription AES GO:0016481 negative_regulation_of_transcription BHLHB3 GO:0016481 negative_regulation_of_transcription HES7 GO:0016481 negative_regulation_of_transcription DDX20 GO:0016481 negative_regulation_of_transcription TLE1 GO:0045892 negative_regulation_of_transcription,_DNA-dependent SIRT7 GO:0045892 negative_regulation_of_transcription,_DNA-dependent TBX2 GO:0045892 negative_regulation_of_transcription,_DNA-dependent BHLHB3 GO:0045892 negative_regulation_of_transcription,_DNA-dependent DDX20 GO:0045892 negative_regulation_of_transcription,_DNA-dependent HES7 GO:0045892 negative_regulation_of_transcription,_DNA-dependent TLE1 GO:0000122 negative_regulation_of_transcription_from_Pol_II_promoter TBX2 GO:0000122 negative_regulation_of_transcription_from_Pol_II_promoter BHLHB3 GO:0000122 negative_regulation_of_transcription_from_Pol_II_promoter HES7 GO:0000122 negative_regulation_of_transcription_from_Pol_II_promoter DDX20 GO:0000122 negative_regulation_of_transcription_from_Pol_II_promoter TLE1 GO:0030512 negative_regulation_of_transforming_growth_factor_beta_receptor_signaling_pathBAMBI GO:0030512 negative_regulation_of_transforming_growth_factor_beta_receptor_signaling_pathCHRDL2 GO:0030178 negative_regulation_of_Wnt_receptor_signaling_pathway DKK1 GO:0008366 nerve_ensheathment PMP22 GO:0042551 nerve_maturation PMP22 GO:0007399 neurogenesis SEMA4C GO:0007399 neurogenesis INHA GO:0007399 neurogenesis DSCAM GO:0007399 neurogenesis SOX14 GO:0007399 neurogenesis PAX3 GO:0007399 neurogenesis SEMA3E GO:0007399 neurogenesis SEMA5B GO:0007399 neurogenesis NR2F1 GO:0007399 neurogenesis GAL GO:0007399 neurogenesis MCF2 GO:0007399 neurogenesis SEMA6A GO:0007399 neurogenesis CRYAB GO:0007399 neurogenesis STMN1 GO:0007399 neurogenesis HMGB2 GO:0007399 neurogenesis HESX1 GO:0007399 neurogenesis BHLHB3

101:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007399 neurogenesis CKB GO:0007399 neurogenesis PAX5 GO:0007399 neurogenesis EMX2 GO:0007399 neurogenesis PMP22 GO:0007399 neurogenesis DKK1 GO:0007399 neurogenesis POU5F1 GO:0007399 neurogenesis IGF1 GO:0050905 neuromuscular_physiological_process GNA11 GO:0050905 neuromuscular_physiological_process GRIN2D GO:0050905 neuromuscular_physiological_process CART GO:0050905 neuromuscular_physiological_process APM2 GO:0050905 neuromuscular_physiological_process CLC GO:0030182 neuron_differentiation EMX2 GO:0042923 neuropeptide_binding BRS3 GO:0042923 neuropeptide_binding CCKBR GO:0005184 neuropeptide_hormone_activity CART GO:0008188 neuropeptide_receptor_activity BRS3 GO:0008188 neuropeptide_receptor_activity CCKBR GO:0007218 neuropeptide_signaling_pathway GRB14 GO:0007218 neuropeptide_signaling_pathway CART GO:0007218 neuropeptide_signaling_pathway GAL GO:0004983 neuropeptide_Y_receptor_activity BRS3 GO:0004983 neuropeptide_Y_receptor_activity CCKBR GO:0050877 neurophysiological_process GNA11 GO:0050877 neurophysiological_process NDUFB9 GO:0050877 neurophysiological_process GRIN2D GO:0050877 neurophysiological_process CART GO:0050877 neurophysiological_process APM2 GO:0050877 neurophysiological_process NR2F1 GO:0050877 neurophysiological_process CLC GO:0007269 neurotransmitter_secretion APM2 GO:0007269 neurotransmitter_secretion CLC GO:0006836 neurotransmitter_transport CLC GO:0005326 neurotransmitter_transporter_activity CLC GO:0006638 neutral_lipid_metabolism GK2 GO:0006638 neutral_lipid_metabolism APOB GO:0016151 nickel_ion_binding AFP GO:0007263 nitric_oxide_mediated_signal_transduction MT1A GO:0006807 nitrogen_metabolism GLB1 GO:0004972 N-methyl-D-aspartate_selective_glutamate_receptor_activity GRIN2D GO:0016582 non-covalent_chromatin_modification SIRT7 GO:0016582 non-covalent_chromatin_modification BAZ1B GO:0004926 non-G-protein_coupled_7TM_receptor_activity FZD7 GO:0004926 non-G-protein_coupled_7TM_receptor_activity FZD4 GO:0007219 Notch_signaling_pathway HES7 GO:0030903 notochord_development DKK1 GO:0000790 nuclear_chromatin DNMT3L GO:0000790 nuclear_chromatin BAZ1B GO:0000790 nuclear_chromatin DNMT3B GO:0000228 nuclear_chromosome DNMT3L GO:0000228 nuclear_chromosome DNMT3B GO:0000228 nuclear_chromosome BAZ1B GO:0000228 nuclear_chromosome SYCP2 GO:0000280 nuclear_division TERF1 GO:0000280 nuclear_division STMN1 GO:0000280 nuclear_division SPAG5 GO:0000280 nuclear_division CETN3 GO:0000280 nuclear_division CDK8 GO:0000280 nuclear_division SYCP2 GO:0000280 nuclear_division PRM2 GO:0042175 nuclear_envelope-endoplasmic_reticulum_network FEN1

102:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005720 nuclear_heterochromatin DNMT3L GO:0005720 nuclear_heterochromatin DNMT3B GO:0005720 nuclear_heterochromatin BAZ1B GO:0005635 nuclear_membrane PTGDS GO:0006997 nuclear_organization_and_biogenesis ASF1A GO:0006997 nuclear_organization_and_biogenesis TERF1 GO:0006997 nuclear_organization_and_biogenesis SIRT7 GO:0006997 nuclear_organization_and_biogenesis MAPK4 GO:0006997 nuclear_organization_and_biogenesis HMGB2 GO:0006997 nuclear_organization_and_biogenesis HSPA1A GO:0006997 nuclear_organization_and_biogenesis NAP1L1 GO:0006997 nuclear_organization_and_biogenesis H2AFY GO:0006997 nuclear_organization_and_biogenesis H1F0 GO:0006997 nuclear_organization_and_biogenesis BAZ1B GO:0006997 nuclear_organization_and_biogenesis PRM2 GO:0004518 nuclease_activity FEN1 GO:0003676 nucleic_acid_binding NARS GO:0003676 nucleic_acid_binding RPL18A GO:0003676 nucleic_acid_binding EPAS1 GO:0003676 nucleic_acid_binding RPL28 GO:0003676 nucleic_acid_binding H2AFY GO:0003676 nucleic_acid_binding JARID2 GO:0003676 nucleic_acid_binding HNRPM GO:0003676 nucleic_acid_binding TBX3 GO:0003676 nucleic_acid_binding SOX30 GO:0003676 nucleic_acid_binding SYCP2 GO:0003676 nucleic_acid_binding MTA3 GO:0003676 nucleic_acid_binding TRPS1 GO:0003676 nucleic_acid_binding LYAR GO:0003676 nucleic_acid_binding PAX5 GO:0003676 nucleic_acid_binding SALL1 GO:0003676 nucleic_acid_binding RNPEP GO:0003676 nucleic_acid_binding POU5F1 GO:0003676 nucleic_acid_binding AHR GO:0003676 nucleic_acid_binding PPP1R12B GO:0003676 nucleic_acid_binding PARG GO:0003676 nucleic_acid_binding ZFP36L2 GO:0003676 nucleic_acid_binding PAX3 GO:0003676 nucleic_acid_binding CEBPD GO:0003676 nucleic_acid_binding DDX20 GO:0003676 nucleic_acid_binding TCF7L2 GO:0003676 nucleic_acid_binding NR2F1 GO:0003676 nucleic_acid_binding H1F0 GO:0003676 nucleic_acid_binding FEM1B GO:0003676 nucleic_acid_binding HEY1 GO:0003676 nucleic_acid_binding SIRT7 GO:0003676 nucleic_acid_binding TBX2 GO:0003676 nucleic_acid_binding SHOX2 GO:0003676 nucleic_acid_binding BHLHB3 GO:0003676 nucleic_acid_binding EMX2 GO:0003676 nucleic_acid_binding ATBF1 GO:0003676 nucleic_acid_binding CIRBP GO:0003676 nucleic_acid_binding BAZ1B GO:0003676 nucleic_acid_binding MKRN1 GO:0003676 nucleic_acid_binding TCEA2 GO:0003676 nucleic_acid_binding TENR GO:0003676 nucleic_acid_binding SOX14 GO:0003676 nucleic_acid_binding EIF3S5 GO:0003676 nucleic_acid_binding KLF12 GO:0003676 nucleic_acid_binding TLX2 GO:0003676 nucleic_acid_binding MLL

103:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0003676 nucleic_acid_binding DNMT3B GO:0003676 nucleic_acid_binding PRM2 GO:0003676 nucleic_acid_binding SSBP1 GO:0003676 nucleic_acid_binding APEH GO:0003676 nucleic_acid_binding ETS2 GO:0003676 nucleic_acid_binding CBFB GO:0003676 nucleic_acid_binding MAPK4 GO:0003676 nucleic_acid_binding RPS8 GO:0003676 nucleic_acid_binding HMGB2 GO:0003676 nucleic_acid_binding NAP1L1 GO:0003676 nucleic_acid_binding HESX1 GO:0003676 nucleic_acid_binding NANOG GO:0003676 nucleic_acid_binding ARID3A GO:0003676 nucleic_acid_binding NSEP1 GO:0003676 nucleic_acid_binding TERF1 GO:0003676 nucleic_acid_binding YBX2 GO:0003676 nucleic_acid_binding RBPMS GO:0003676 nucleic_acid_binding HDLBP GO:0003676 nucleic_acid_binding HNF3B GO:0003676 nucleic_acid_binding ARNTL GO:0003676 nucleic_acid_binding KHDRBS3 GO:0003676 nucleic_acid_binding AR GO:0003676 nucleic_acid_binding DDX25 GO:0003676 nucleic_acid_binding ZFP36L1 GO:0003676 nucleic_acid_binding FOXA1 GO:0003676 nucleic_acid_binding FEN1 GO:0003676 nucleic_acid_binding TCF8 GO:0003676 nucleic_acid_binding NFIA GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism NARS GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism TLE4 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism EPAS1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism H2AFY GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism TBX3 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism GMPR GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism SOX30 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism ATIC GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism MID1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism MTA3 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism TRPS1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism SALL1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism PAX5 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism CDK8 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism POU5F1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism ASF1A GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism AHR GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism PPP1R12B GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism NUDT1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism PAX3 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism CEBPD GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism CDH16 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism AES GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism DDX20 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism TCF7L2 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism TLE1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism H1F0 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism NR2F1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism FEM1B GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism HEY1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism DNMT3L GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism SIRT7 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism TBX2

104:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism PAICS GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism GNE GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism CITED1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism PRNP GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism SHOX2 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism BHLHB3 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism ATBF1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism EMX2 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism BAZ1B GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism TCEA2 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism TENR GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism SOX14 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism KLF12 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism TLX2 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism DNMT3B GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism MLL GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism APEH GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism ATP6V1E2 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism SSBP1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism ETS2 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism CBFB GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism MAPK4 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism WARS GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism HMGB2 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism NAP1L1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism HESX1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism ARID3A GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism NSEP1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism HNF3B GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism ARNTL GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism AR GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism TK1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism AMPD2 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism GMPR2 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism TBPL1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism FOXA1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism HSPA1A GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism FEN1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism TCF8 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism ACE2 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism HES7 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism FHL2 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism UPP1 GO:0006139 nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolism NFIA GO:0019205 nucleobase,_nucleoside,_nucleotide_kinase_activity UMPK GO:0019205 nucleobase,_nucleoside,_nucleotide_kinase_activity TK1 GO:0009112 nucleobase_metabolism AMPD2 GO:0006913 nucleocytoplasmic_transport ARNTL GO:0005730 nucleolus NOL6 GO:0005730 nucleolus PWP1 GO:0005730 nucleolus PRH1 GO:0005654 nucleoplasm ASF1A GO:0005654 nucleoplasm AHR GO:0005654 nucleoplasm HNF3B GO:0005654 nucleoplasm PAX3 GO:0005654 nucleoplasm SOX14 GO:0005654 nucleoplasm DDX20 GO:0005654 nucleoplasm TLX2 GO:0005654 nucleoplasm TCF7L2 GO:0005654 nucleoplasm NR2F1 GO:0005654 nucleoplasm SOX30

105:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005654 nucleoplasm SIRT7 GO:0005654 nucleoplasm CBFB GO:0005654 nucleoplasm TBX2 GO:0005654 nucleoplasm SHOX2 GO:0005654 nucleoplasm FOXA1 GO:0005654 nucleoplasm HESX1 GO:0005654 nucleoplasm BHLHB3 GO:0005654 nucleoplasm PAX5 GO:0005654 nucleoplasm CDK8 GO:0019206 nucleoside_kinase_activity UMPK GO:0019206 nucleoside_kinase_activity TK1 GO:0009116 nucleoside_metabolism UPP1 GO:0009116 nucleoside_metabolism TBPL1 GO:0009124 nucleoside_monophosphate_biosynthesis PAICS GO:0009124 nucleoside_monophosphate_biosynthesis AMPD2 GO:0009125 nucleoside_monophosphate_catabolism GMPR2 GO:0009123 nucleoside_monophosphate_metabolism PAICS GO:0009123 nucleoside_monophosphate_metabolism AMPD2 GO:0009123 nucleoside_monophosphate_metabolism GMPR2 GO:0006753 nucleoside_phosphate_metabolism ATP6V1E2 GO:0009142 nucleoside_triphosphate_biosynthesis TBPL1 GO:0009142 nucleoside_triphosphate_biosynthesis ATP6V1E2 GO:0009143 nucleoside_triphosphate_catabolism NUDT1 GO:0009141 nucleoside_triphosphate_metabolism NUDT1 GO:0009141 nucleoside_triphosphate_metabolism TBPL1 GO:0009141 nucleoside_triphosphate_metabolism ATP6V1E2 GO:0000786 nucleosome MAPK4 GO:0000786 nucleosome H2AFY GO:0000786 nucleosome H1F0 GO:0000786 nucleosome PRM2 GO:0006334 nucleosome_assembly ASF1A GO:0006334 nucleosome_assembly MAPK4 GO:0006334 nucleosome_assembly NAP1L1 GO:0006334 nucleosome_assembly H2AFY GO:0006334 nucleosome_assembly H1F0 GO:0000166 nucleotide_binding PRKAA1 GO:0000166 nucleotide_binding GK2 GO:0000166 nucleotide_binding PRKAR2B GO:0000166 nucleotide_binding NARS GO:0000166 nucleotide_binding ARL4 GO:0000166 nucleotide_binding UMPK GO:0000166 nucleotide_binding DRG1 GO:0000166 nucleotide_binding RRAS2 GO:0000166 nucleotide_binding OCA2 GO:0000166 nucleotide_binding MAPK4 GO:0000166 nucleotide_binding WARS GO:0000166 nucleotide_binding ITM2B GO:0000166 nucleotide_binding EPHA3 GO:0000166 nucleotide_binding CDK8 GO:0000166 nucleotide_binding NRBP GO:0000166 nucleotide_binding MAP3K5 GO:0000166 nucleotide_binding MYH11 GO:0000166 nucleotide_binding ATP12A GO:0000166 nucleotide_binding GNA11 GO:0000166 nucleotide_binding SLC2A1 GO:0000166 nucleotide_binding GNAI1 GO:0000166 nucleotide_binding CDH16 GO:0000166 nucleotide_binding TK1 GO:0000166 nucleotide_binding DDX20 GO:0000166 nucleotide_binding PRKAR2A GO:0000166 nucleotide_binding DDX25

106:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0000166 nucleotide_binding TESK2 GO:0000166 nucleotide_binding GNE GO:0000166 nucleotide_binding HSPA1A GO:0000166 nucleotide_binding CCT2 GO:0000166 nucleotide_binding DHX35 GO:0000166 nucleotide_binding ROR1 GO:0009165 nucleotide_biosynthesis ATIC GO:0009165 nucleotide_biosynthesis PAICS GO:0009165 nucleotide_biosynthesis AMPD2 GO:0009165 nucleotide_biosynthesis TBPL1 GO:0009165 nucleotide_biosynthesis ATP6V1E2 GO:0009166 nucleotide_catabolism NUDT1 GO:0009166 nucleotide_catabolism GMPR2 GO:0009117 nucleotide_metabolism ATIC GO:0009117 nucleotide_metabolism NUDT1 GO:0009117 nucleotide_metabolism PAICS GO:0009117 nucleotide_metabolism AMPD2 GO:0009117 nucleotide_metabolism GMPR2 GO:0009117 nucleotide_metabolism TBPL1 GO:0009117 nucleotide_metabolism GMPR GO:0009117 nucleotide_metabolism ATP6V1E2 GO:0016502 nucleotide_receptor_activity ADORA2B GO:0001608 nucleotide_receptor_activity,_G-protein_coupled ADORA2B GO:0009225 nucleotide-sugar_metabolism GNE GO:0016779 nucleotidyltransferase_activity CCT2 GO:0005634 nucleus TLE4 GO:0005634 nucleus EPAS1 GO:0005634 nucleus RPL28 GO:0005634 nucleus H2AFY GO:0005634 nucleus JARID2 GO:0005634 nucleus TBX3 GO:0005634 nucleus HNRPM GO:0005634 nucleus HDGF GO:0005634 nucleus SOX30 GO:0005634 nucleus SYCP2 GO:0005634 nucleus MID1 GO:0005634 nucleus MTA3 GO:0005634 nucleus TRPS1 GO:0005634 nucleus LYAR GO:0005634 nucleus PAX5 GO:0005634 nucleus SALL1 GO:0005634 nucleus WBSCR22 GO:0005634 nucleus CDK8 GO:0005634 nucleus NRBP GO:0005634 nucleus POU5F1 GO:0005634 nucleus ASF1A GO:0005634 nucleus AHR GO:0005634 nucleus ZFP36L2 GO:0005634 nucleus NOL6 GO:0005634 nucleus CEBPD GO:0005634 nucleus PAX3 GO:0005634 nucleus AES GO:0005634 nucleus PCBD GO:0005634 nucleus DDX20 GO:0005634 nucleus PTPN13 GO:0005634 nucleus TCF7L2 GO:0005634 nucleus PRH1 GO:0005634 nucleus TLE1 GO:0005634 nucleus H1F0 GO:0005634 nucleus NR2F1 GO:0005634 nucleus HEY1

107:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005634 nucleus SIRT7 GO:0005634 nucleus DNMT3L GO:0005634 nucleus TESK2 GO:0005634 nucleus TBX2 GO:0005634 nucleus CITED1 GO:0005634 nucleus SHOX2 GO:0005634 nucleus BHLHB3 GO:0005634 nucleus ATBF1 GO:0005634 nucleus EMX2 GO:0005634 nucleus CIRBP GO:0005634 nucleus BAZ1B GO:0005634 nucleus UBA2 GO:0005634 nucleus TCEA2 GO:0005634 nucleus ARL4 GO:0005634 nucleus GADD45A GO:0005634 nucleus SOX14 GO:0005634 nucleus KLF12 GO:0005634 nucleus PWP1 GO:0005634 nucleus TLX2 GO:0005634 nucleus MLL GO:0005634 nucleus DNMT3B GO:0005634 nucleus APEH GO:0005634 nucleus PRM2 GO:0005634 nucleus ETS2 GO:0005634 nucleus PTGES GO:0005634 nucleus MLF1 GO:0005634 nucleus CBFB GO:0005634 nucleus MAPK4 GO:0005634 nucleus HMGB2 GO:0005634 nucleus TBC1D1 GO:0005634 nucleus NAP1L1 GO:0005634 nucleus HESX1 GO:0005634 nucleus PLEKHA1 GO:0005634 nucleus ID2 GO:0005634 nucleus NANOG GO:0005634 nucleus ARID3A GO:0005634 nucleus NSEP1 GO:0005634 nucleus TERF1 GO:0005634 nucleus HDLBP GO:0005634 nucleus ARNTL GO:0005634 nucleus HNF3B GO:0005634 nucleus AR GO:0005634 nucleus TIP120B GO:0005634 nucleus TBPL1 GO:0005634 nucleus PTGDS GO:0005634 nucleus ZFP36L1 GO:0005634 nucleus BAP1 GO:0005634 nucleus FOXA1 GO:0005634 nucleus FEN1 GO:0005634 nucleus TCF8 GO:0005634 nucleus ACE2 GO:0005634 nucleus FHL2 GO:0005634 nucleus NFIA GO:0008369 obsolete_molecular_function ARL4 GO:0008369 obsolete_molecular_function GNAI1 GO:0006857 oligopeptide_transport CDH17 GO:0015198 oligopeptide_transporter_activity CDH17 GO:0009993 oogenesis_(sensu_Insecta) MSN GO:0000313 organellar_ribosome RPS8 GO:0000314 organellar_small_ribosomal_subunit RPS8 GO:0006996 organelle_organization_and_biogenesis MYH11

108:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006996 organelle_organization_and_biogenesis ARPC1A GO:0006996 organelle_organization_and_biogenesis APG3 GO:0006996 organelle_organization_and_biogenesis CKAP1 GO:0006996 organelle_organization_and_biogenesis TAGLN GO:0006996 organelle_organization_and_biogenesis PLS3 GO:0006996 organelle_organization_and_biogenesis CAPZB GO:0006996 organelle_organization_and_biogenesis ELN GO:0006996 organelle_organization_and_biogenesis CAPZA3 GO:0006996 organelle_organization_and_biogenesis STMN1 GO:0006996 organelle_organization_and_biogenesis MSN GO:0006996 organelle_organization_and_biogenesis BFSP2 GO:0006996 organelle_organization_and_biogenesis DNCL2A GO:0006996 organelle_organization_and_biogenesis CCT2 GO:0016053 organic_acid_biosynthesis GGTLA1 GO:0016053 organic_acid_biosynthesis PRKAA1 GO:0016053 organic_acid_biosynthesis ACAS2L GO:0016053 organic_acid_biosynthesis ELOVL4 GO:0016053 organic_acid_biosynthesis FEN1 GO:0016053 organic_acid_biosynthesis PTGDS GO:0006082 organic_acid_metabolism PRKAA1 GO:0006082 organic_acid_metabolism PRKAR2B GO:0006082 organic_acid_metabolism NARS GO:0006082 organic_acid_metabolism BCAT1 GO:0006082 organic_acid_metabolism PCBD GO:0006082 organic_acid_metabolism CDH16 GO:0006082 organic_acid_metabolism TNFRSF1A GO:0006082 organic_acid_metabolism PTGDS GO:0006082 organic_acid_metabolism INDO GO:0006082 organic_acid_metabolism PTGES GO:0006082 organic_acid_metabolism TMLHE GO:0006082 organic_acid_metabolism GGTLA1 GO:0006082 organic_acid_metabolism ACAS2L GO:0006082 organic_acid_metabolism FOLR1 GO:0006082 organic_acid_metabolism ELOVL4 GO:0006082 organic_acid_metabolism GNE GO:0006082 organic_acid_metabolism WARS GO:0006082 organic_acid_metabolism FEN1 GO:0006082 organic_acid_metabolism GFPT2 GO:0006082 organic_acid_metabolism CBS GO:0015849 organic_acid_transport SLCO2A1 GO:0015849 organic_acid_transport SLC7A11 GO:0005342 organic_acid_transporter_activity SLCO2A1 GO:0005342 organic_acid_transporter_activity SLC7A11 GO:0015711 organic_anion_transport SLCO2A1 GO:0008514 organic_anion_transporter_activity SLCO2A1 GO:0050879 organismal_movement GNA11 GO:0050879 organismal_movement CART GO:0050879 organismal_movement GRIN2D GO:0050879 organismal_movement APM2 GO:0050879 organismal_movement NR2F1 GO:0050879 organismal_movement CLC GO:0050874 organismal_physiological_process INHA GO:0050874 organismal_physiological_process PTGER3 GO:0050874 organismal_physiological_process GAL GO:0050874 organismal_physiological_process TM4SF3 GO:0050874 organismal_physiological_process INDO GO:0050874 organismal_physiological_process AFP GO:0050874 organismal_physiological_process GGTLA1 GO:0050874 organismal_physiological_process CBFB GO:0050874 organismal_physiological_process IL27RA GO:0050874 organismal_physiological_process TLR8

109:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0050874 organismal_physiological_process APM2 GO:0050874 organismal_physiological_process FGG GO:0050874 organismal_physiological_process GDF10 GO:0050874 organismal_physiological_process APOA2 GO:0050874 organismal_physiological_process AGTRAP GO:0050874 organismal_physiological_process LST1 GO:0050874 organismal_physiological_process PAP GO:0050874 organismal_physiological_process GNA11 GO:0050874 organismal_physiological_process GRIN2D GO:0050874 organismal_physiological_process RNF128 GO:0050874 organismal_physiological_process C6 GO:0050874 organismal_physiological_process TNFRSF1A GO:0050874 organismal_physiological_process NR2F1 GO:0050874 organismal_physiological_process PTGDS GO:0050874 organismal_physiological_process F2 GO:0050874 organismal_physiological_process NDUFB9 GO:0050874 organismal_physiological_process FN1 GO:0050874 organismal_physiological_process CART GO:0050874 organismal_physiological_process CX3CL1 GO:0050874 organismal_physiological_process COL1A1 GO:0050874 organismal_physiological_process SERPINC1 GO:0050874 organismal_physiological_process CLC GO:0009887 organogenesis INHA GO:0009887 organogenesis PRKAR2B GO:0009887 organogenesis DSCAM GO:0009887 organogenesis EPAS1 GO:0009887 organogenesis GAL GO:0009887 organogenesis CKB GO:0009887 organogenesis PAX5 GO:0009887 organogenesis SALL1 GO:0009887 organogenesis TNA GO:0009887 organogenesis POU5F1 GO:0009887 organogenesis PAX3 GO:0009887 organogenesis AES GO:0009887 organogenesis SEMA5B GO:0009887 organogenesis DDX20 GO:0009887 organogenesis NR2F1 GO:0009887 organogenesis CUL1 GO:0009887 organogenesis BHLHB3 GO:0009887 organogenesis EMX2 GO:0009887 organogenesis PMP22 GO:0009887 organogenesis COL1A1 GO:0009887 organogenesis DKK1 GO:0009887 organogenesis SEMA4C GO:0009887 organogenesis SOX14 GO:0009887 organogenesis SEMA3E GO:0009887 organogenesis TNNT3 GO:0009887 organogenesis TAGLN GO:0009887 organogenesis AFP GO:0009887 organogenesis CBFB GO:0009887 organogenesis HMGB2 GO:0009887 organogenesis HESX1 GO:0009887 organogenesis GDF10 GO:0009887 organogenesis EPHA3 GO:0009887 organogenesis MYH11 GO:0009887 organogenesis GNA11 GO:0009887 organogenesis BMP2 GO:0009887 organogenesis ANXA4 GO:0009887 organogenesis AR GO:0009887 organogenesis GPC3 GO:0009887 organogenesis TNFRSF1A

110:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0009887 organogenesis GMPR2 GO:0009887 organogenesis MCF2 GO:0009887 organogenesis ELN GO:0009887 organogenesis SEMA6A GO:0009887 organogenesis INSL3 GO:0009887 organogenesis CRYAB GO:0009887 organogenesis STMN1 GO:0009887 organogenesis ADORA2B GO:0009887 organogenesis FBLN1 GO:0009887 organogenesis IGF1 GO:0001503 ossification CBFB GO:0001503 ossification GDF10 GO:0001503 ossification COL1A1 GO:0019867 outer_membrane GK2 GO:0019867 outer_membrane ROPN1 GO:0001541 ovarian_follicle_development INHA GO:0030728 ovulation AFP GO:0001542 ovulation_(sensu_Mammalia) AFP GO:0006119 oxidative_phosphorylation NDUFB9 GO:0006119 oxidative_phosphorylation ATP6V1E2 GO:0016491 oxidoreductase_activity CYP17A1 GO:0016491 oxidoreductase_activity FZD7 GO:0016491 oxidoreductase_activity NQO1 GO:0016491 oxidoreductase_activity AASS GO:0016491 oxidoreductase_activity DHRS10 GO:0016491 oxidoreductase_activity CYP26A1 GO:0016491 oxidoreductase_activity CBR3 GO:0016491 oxidoreductase_activity COX7C GO:0016491 oxidoreductase_activity GMPR2 GO:0016491 oxidoreductase_activity INDO GO:0016491 oxidoreductase_activity GMPR GO:0016491 oxidoreductase_activity TMLHE GO:0016491 oxidoreductase_activity LDHA GO:0016491 oxidoreductase_activity LOXL1 GO:0016491 oxidoreductase_activity HSD17B1 GO:0016491 oxidoreductase_activity NDUFB9 GO:0016491 oxidoreductase_activity FN1 GO:0016491 oxidoreductase_activity ALDH1A3 GO:0016491 oxidoreductase_activity LAMB2 GO:0016491 oxidoreductase_activity COX6A2 GO:0016491 oxidoreductase_activity HSD3B2 GO:0016491 oxidoreductase_activity CBR1 GO:0016491 oxidoreductase_activity CYP19A1 GO:0016491 oxidoreductase_activity HSD3B1 GO:0016614 oxidoreductase_activity,_acting_on_CH-OH_group_of_donors LDHA GO:0016614 oxidoreductase_activity,_acting_on_CH-OH_group_of_donors HSD17B1 GO:0016614 oxidoreductase_activity,_acting_on_CH-OH_group_of_donors HSD3B2 GO:0016614 oxidoreductase_activity,_acting_on_CH-OH_group_of_donors CBR1 GO:0016614 oxidoreductase_activity,_acting_on_CH-OH_group_of_donors CBR3 GO:0016614 oxidoreductase_activity,_acting_on_CH-OH_group_of_donors HSD3B1 GO:0016675 oxidoreductase_activity,_acting_on_heme_group_of_donors COX6A2 GO:0016675 oxidoreductase_activity,_acting_on_heme_group_of_donors COX7C GO:0016676 oxidoreductase_activity,_acting_on_heme_group_of_donors,_oxygen_as_acceptoCOX6A2 GO:0016676 oxidoreductase_activity,_acting_on_heme_group_of_donors,_oxygen_as_acceptoCOX7C GO:0016651 oxidoreductase_activity,_acting_on_NADH_or_NADPH NQO1 GO:0016651 oxidoreductase_activity,_acting_on_NADH_or_NADPH NDUFB9 GO:0016651 oxidoreductase_activity,_acting_on_NADH_or_NADPH CBR1 GO:0016651 oxidoreductase_activity,_acting_on_NADH_or_NADPH GMPR2 GO:0016651 oxidoreductase_activity,_acting_on_NADH_or_NADPH GMPR GO:0016652 oxidoreductase_activity,_acting_on_NADH_or_NADPH,_NAD_or_NADP_as_acceCBR1 GO:0016657 oxidoreductase_activity,_acting_on_NADH_or_NADPH,_nitrogenous_group_as_aGMPR2

111:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0016657 oxidoreductase_activity,_acting_on_NADH_or_NADPH,_nitrogenous_group_as_aGMPR GO:0016655 oxidoreductase_activity,_acting_on_NADH_or_NADPH,_quinone_or_similar_com NDUFB9 GO:0016705 oxidoreductase_activity,_acting_on_paired_donors,_with_incorporation_or_reduct CYP17A1 GO:0016684 oxidoreductase_activity,_acting_on_peroxide_as_acceptor AASS GO:0016701 oxidoreductase_activity,_acting_on_single_donors_with_incorporation_of_molecu TMLHE GO:0016701 oxidoreductase_activity,_acting_on_single_donors_with_incorporation_of_molecu INDO GO:0016702 oxidoreductase_activity,_acting_on_single_donors_with_incorporation_of_molecu TMLHE GO:0016702 oxidoreductase_activity,_acting_on_single_donors_with_incorporation_of_molecu INDO GO:0016903 oxidoreductase_activity,_acting_on_the_aldehyde_or_oxo_group_of_donors ALDH1A3 GO:0016620 oxidoreductase_activity,_acting_on_the_aldehyde_or_oxo_group_of_donors,_NADALDH1A3 GO:0016638 oxidoreductase_activity,_acting_on_the_CH-NH2_group_of_donors LOXL1 GO:0016641 oxidoreductase_activity,_acting_on_the_CH-NH2_group_of_donors,_oxygen_as_ LOXL1 GO:0016616 oxidoreductase_activity,_acting_on_the_CH-OH_group_of_donors,_NAD_or_NADLDHA GO:0016616 oxidoreductase_activity,_acting_on_the_CH-OH_group_of_donors,_NAD_or_NADHSD17B1 GO:0016616 oxidoreductase_activity,_acting_on_the_CH-OH_group_of_donors,_NAD_or_NADHSD3B2 GO:0016616 oxidoreductase_activity,_acting_on_the_CH-OH_group_of_donors,_NAD_or_NADCBR1 GO:0016616 oxidoreductase_activity,_acting_on_the_CH-OH_group_of_donors,_NAD_or_NADCBR3 GO:0016616 oxidoreductase_activity,_acting_on_the_CH-OH_group_of_donors,_NAD_or_NADHSD3B1 GO:0006800 oxygen_and_reactive_oxygen_species_metabolism GGTLA1 GO:0006800 oxygen_and_reactive_oxygen_species_metabolism PRNP GO:0007389 pattern_specification BAMBI GO:0007389 pattern_specification EMX2 GO:0007389 pattern_specification EPHA3 GO:0007389 pattern_specification POU5F1 GO:0008233 peptidase_activity SPAG5 GO:0008233 peptidase_activity MMP11 GO:0008233 peptidase_activity CAPNS1 GO:0008233 peptidase_activity TENR GO:0008233 peptidase_activity PLAT GO:0008233 peptidase_activity RNF128 GO:0008233 peptidase_activity FAP GO:0008233 peptidase_activity APEH GO:0008233 peptidase_activity F2 GO:0008233 peptidase_activity COL6A1 GO:0008233 peptidase_activity BAP1 GO:0008233 peptidase_activity ENPEP GO:0008233 peptidase_activity C1R GO:0008233 peptidase_activity ADAMTS19 GO:0008233 peptidase_activity ACE2 GO:0008233 peptidase_activity ZMPSTE24 GO:0008233 peptidase_activity RNPEP GO:0008233 peptidase_activity CASP7 GO:0042605 peptide_antigen_binding IL27RA GO:0042277 peptide_binding IL27RA GO:0042277 peptide_binding BRS3 GO:0042277 peptide_binding AGTRAP GO:0042277 peptide_binding CCKBR GO:0001653 peptide_receptor_activity BRS3 GO:0001653 peptide_receptor_activity CCKBR GO:0001653 peptide_receptor_activity AGTRAP GO:0008528 peptide_receptor_activity,_G-protein_coupled BRS3 GO:0008528 peptide_receptor_activity,_G-protein_coupled AGTRAP GO:0008528 peptide_receptor_activity,_G-protein_coupled CCKBR GO:0015833 peptide_transport CDH17 GO:0015197 peptide_transporter_activity CDH17 GO:0004246 peptidyl-dipeptidase_A_activity ACE2 GO:0008241 peptidyl-dipeptidase_activity ACE2 GO:0003755 peptidyl-prolyl_cis-trans_isomerase_activity CPR8 GO:0003755 peptidyl-prolyl_cis-trans_isomerase_activity PPIC GO:0007605 perception_of_sound NDUFB9 GO:0005653 perinuclear_space PTGES

112:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007422 peripheral_nervous_system_development DSCAM GO:0007422 peripheral_nervous_system_development CRYAB GO:0004601 peroxidase_activity AASS GO:0005777 peroxisome IDI1 GO:0009699 phenylpropanoid_biosynthesis GLB1 GO:0009698 phenylpropanoid_metabolism GLB1 GO:0042396 phosphagen_biosynthesis CKMT2 GO:0006599 phosphagen_metabolism CKMT2 GO:0006599 phosphagen_metabolism CKB GO:0006796 phosphate_metabolism DUSP6 GO:0006796 phosphate_metabolism PRKAA1 GO:0006796 phosphate_metabolism INHA GO:0006796 phosphate_metabolism PRKAR2B GO:0006796 phosphate_metabolism PTPRK GO:0006796 phosphate_metabolism GADD45A GO:0006796 phosphate_metabolism PTPN13 GO:0006796 phosphate_metabolism PRKAR2A GO:0006796 phosphate_metabolism PTPRR GO:0006796 phosphate_metabolism ATP6V1E2 GO:0006796 phosphate_metabolism OCA2 GO:0006796 phosphate_metabolism TESK2 GO:0006796 phosphate_metabolism MAPK4 GO:0006796 phosphate_metabolism NDUFB9 GO:0006796 phosphate_metabolism MSN GO:0006796 phosphate_metabolism PPP6C GO:0006796 phosphate_metabolism CCT2 GO:0006796 phosphate_metabolism EPHA3 GO:0006796 phosphate_metabolism CDK8 GO:0006796 phosphate_metabolism ROR1 GO:0006796 phosphate_metabolism MAP3K5 GO:0006817 phosphate_transport SLC17A1 GO:0015114 phosphate_transporter_activity SLC17A1 GO:0006646 phosphatidylethanolamine_biosynthesis EKI1 GO:0046337 phosphatidylethanolamine_metabolism EKI1 GO:0046314 phosphocreatine_biosynthesis CKMT2 GO:0006603 phosphocreatine_metabolism CKMT2 GO:0006603 phosphocreatine_metabolism CKB GO:0004618 phosphoglycerate_kinase_activity PGK1 GO:0004623 phospholipase_A2_activity WISP2 GO:0004623 phospholipase_A2_activity LAMB2 GO:0019834 phospholipase_A2_inhibitor_activity ANXA3 GO:0004620 phospholipase_activity WISP2 GO:0004620 phospholipase_activity LAMB2 GO:0004859 phospholipase_inhibitor_activity ANXA3 GO:0005543 phospholipid_binding ANXA4 GO:0005543 phospholipid_binding ANXA3 GO:0005543 phospholipid_binding ANXA9 GO:0008654 phospholipid_biosynthesis EKI1 GO:0006644 phospholipid_metabolism CCT2 GO:0006644 phospholipid_metabolism EKI1 GO:0004721 phosphoprotein_phosphatase_activity DUSP6 GO:0004721 phosphoprotein_phosphatase_activity PTPRD GO:0004721 phosphoprotein_phosphatase_activity PTPRK GO:0004721 phosphoprotein_phosphatase_activity PPP6C GO:0004721 phosphoprotein_phosphatase_activity PTPN13 GO:0004721 phosphoprotein_phosphatase_activity PTPRR GO:0004721 phosphoprotein_phosphatase_activity CDKN3 GO:0004638 phosphoribosylaminoimidazole_carboxylase_activity PAICS GO:0009320 phosphoribosylaminoimidazole_carboxylase_complex PAICS GO:0004643 phosphoribosylaminoimidazolecarboxamide_formyltransferase_activity ATIC GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide_synthase_activity PAICS

113:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0042578 phosphoric_ester_hydrolase_activity DUSP6 GO:0042578 phosphoric_ester_hydrolase_activity PTPRD GO:0042578 phosphoric_ester_hydrolase_activity ALPI GO:0042578 phosphoric_ester_hydrolase_activity PTPRK GO:0042578 phosphoric_ester_hydrolase_activity PPP6C GO:0042578 phosphoric_ester_hydrolase_activity PTPN13 GO:0042578 phosphoric_ester_hydrolase_activity PTPRR GO:0042578 phosphoric_ester_hydrolase_activity CDKN3 GO:0016791 phosphoric_monoester_hydrolase_activity DUSP6 GO:0016791 phosphoric_monoester_hydrolase_activity PTPRD GO:0016791 phosphoric_monoester_hydrolase_activity ALPI GO:0016791 phosphoric_monoester_hydrolase_activity PTPRK GO:0016791 phosphoric_monoester_hydrolase_activity PPP6C GO:0016791 phosphoric_monoester_hydrolase_activity PTPN13 GO:0016791 phosphoric_monoester_hydrolase_activity CDKN3 GO:0016791 phosphoric_monoester_hydrolase_activity PTPRR GO:0006793 phosphorus_metabolism DUSP6 GO:0006793 phosphorus_metabolism PRKAA1 GO:0006793 phosphorus_metabolism INHA GO:0006793 phosphorus_metabolism PRKAR2B GO:0006793 phosphorus_metabolism PTPRK GO:0006793 phosphorus_metabolism GADD45A GO:0006793 phosphorus_metabolism PTPN13 GO:0006793 phosphorus_metabolism PRKAR2A GO:0006793 phosphorus_metabolism PTPRR GO:0006793 phosphorus_metabolism ATP6V1E2 GO:0006793 phosphorus_metabolism OCA2 GO:0006793 phosphorus_metabolism TESK2 GO:0006793 phosphorus_metabolism NDUFB9 GO:0006793 phosphorus_metabolism MAPK4 GO:0006793 phosphorus_metabolism MSN GO:0006793 phosphorus_metabolism PPP6C GO:0006793 phosphorus_metabolism CCT2 GO:0006793 phosphorus_metabolism CDK8 GO:0006793 phosphorus_metabolism EPHA3 GO:0006793 phosphorus_metabolism MAP3K5 GO:0006793 phosphorus_metabolism ROR1 GO:0004689 phosphorylase_kinase_activity PGK1 GO:0005964 phosphorylase_kinase_complex PGK1 GO:0016310 phosphorylation PRKAA1 GO:0016310 phosphorylation INHA GO:0016310 phosphorylation PRKAR2B GO:0016310 phosphorylation GADD45A GO:0016310 phosphorylation PRKAR2A GO:0016310 phosphorylation ATP6V1E2 GO:0016310 phosphorylation OCA2 GO:0016310 phosphorylation TESK2 GO:0016310 phosphorylation NDUFB9 GO:0016310 phosphorylation MAPK4 GO:0016310 phosphorylation MSN GO:0016310 phosphorylation CCT2 GO:0016310 phosphorylation CDK8 GO:0016310 phosphorylation EPHA3 GO:0016310 phosphorylation MAP3K5 GO:0016310 phosphorylation ROR1 GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor PRKAA1 GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor GK2 GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor EKI1 GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor PRKAR2A GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor OCA2 GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor TESK2

114:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor MAPK4 GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor PGK1 GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor MSN GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor CCT2 GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor EPHA3 GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor CDK8 GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor NRBP GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor ROR1 GO:0016773 phosphotransferase_activity,_alcohol_group_as_acceptor MAP3K5 GO:0016774 phosphotransferase_activity,_carboxyl_group_as_acceptor PGK1 GO:0016775 phosphotransferase_activity,_nitrogenous_group_as_acceptor CKMT2 GO:0016775 phosphotransferase_activity,_nitrogenous_group_as_acceptor CKB GO:0042461 photoreceptor_cell_development MSN GO:0046530 photoreceptor_cell_differentiation MSN GO:0008594 photoreceptor_cell_morphogenesis_(sensu_Drosophila) MSN GO:0007467 photoreceptor_differentiation_(sensu_Drosophila) MSN GO:0007602 phototransduction PDCL3 GO:0007582 physiological_process INHA GO:0007582 physiological_process PRKAR2B GO:0007582 physiological_process TLE4 GO:0007582 physiological_process CLIC6 GO:0007582 physiological_process STAR GO:0007582 physiological_process GSTA1 GO:0007582 physiological_process SSPN GO:0007582 physiological_process MTA3 GO:0007582 physiological_process HSD17B1 GO:0007582 physiological_process ENPEP GO:0007582 physiological_process SLC2A3 GO:0007582 physiological_process PAX5 GO:0007582 physiological_process FZD7 GO:0007582 physiological_process AHR GO:0007582 physiological_process PARG GO:0007582 physiological_process BCAT1 GO:0007582 physiological_process PLAT GO:0007582 physiological_process PTPRK GO:0007582 physiological_process AES GO:0007582 physiological_process PLS3 GO:0007582 physiological_process DDX20 GO:0007582 physiological_process VLDLR GO:0007582 physiological_process PTPRR GO:0007582 physiological_process ART3 GO:0007582 physiological_process SIRT7 GO:0007582 physiological_process DNMT3L GO:0007582 physiological_process ACAS2L GO:0007582 physiological_process NDUFB9 GO:0007582 physiological_process CART GO:0007582 physiological_process APOE GO:0007582 physiological_process CX3CL1 GO:0007582 physiological_process DNCL2A GO:0007582 physiological_process PMP22 GO:0007582 physiological_process PRKAA1 GO:0007582 physiological_process GK2 GO:0007582 physiological_process HEBP1 GO:0007582 physiological_process SCN9A GO:0007582 physiological_process KLF12 GO:0007582 physiological_process BAG5 GO:0007582 physiological_process TLX2 GO:0007582 physiological_process MLL GO:0007582 physiological_process TM4SF3 GO:0007582 physiological_process APEH GO:0007582 physiological_process PTGES

115:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007582 physiological_process FXYD6 GO:0007582 physiological_process CDH17 GO:0007582 physiological_process RPS8 GO:0007582 physiological_process WARS GO:0007582 physiological_process HESX1 GO:0007582 physiological_process CACNA1C GO:0007582 physiological_process PPP6C GO:0007582 physiological_process MPZ GO:0007582 physiological_process GGPS1 GO:0007582 physiological_process MYH11 GO:0007582 physiological_process TERF1 GO:0007582 physiological_process ANXA4 GO:0007582 physiological_process HNF3B GO:0007582 physiological_process GMPR2 GO:0007582 physiological_process CRYAB GO:0007582 physiological_process LDHA GO:0007582 physiological_process AMBP GO:0007582 physiological_process FN1 GO:0007582 physiological_process FOXA1 GO:0007582 physiological_process HES7 GO:0007582 physiological_process ROR1 GO:0007582 physiological_process IGF1 GO:0007582 physiological_process SPAG5 GO:0007582 physiological_process DUSP6 GO:0007582 physiological_process CALB1 GO:0007582 physiological_process GSTP1 GO:0007582 physiological_process RPL18A GO:0007582 physiological_process CYP26A1 GO:0007582 physiological_process RPL28 GO:0007582 physiological_process STX6 GO:0007582 physiological_process GAL GO:0007582 physiological_process RRAS2 GO:0007582 physiological_process SOX30 GO:0007582 physiological_process OCA2 GO:0007582 physiological_process MID1 GO:0007582 physiological_process ELOVL4 GO:0007582 physiological_process TRPS1 GO:0007582 physiological_process ALPI GO:0007582 physiological_process TLR8 GO:0007582 physiological_process CBR1 GO:0007582 physiological_process PDZK1 GO:0007582 physiological_process CYP19A1 GO:0007582 physiological_process CASP7 GO:0007582 physiological_process AP2B1 GO:0007582 physiological_process PPP1R12B GO:0007582 physiological_process GLB1 GO:0007582 physiological_process PTPN13 GO:0007582 physiological_process CAPZB GO:0007582 physiological_process NR2F1 GO:0007582 physiological_process FEM1B GO:0007582 physiological_process SLC19A2 GO:0007582 physiological_process CUL1 GO:0007582 physiological_process GNE GO:0007582 physiological_process SHOX2 GO:0007582 physiological_process PRNP GO:0007582 physiological_process CCT2 GO:0007582 physiological_process APOB GO:0007582 physiological_process GFPT2 GO:0007582 physiological_process BAZ1B GO:0007582 physiological_process CYP17A1 GO:0007582 physiological_process COPE

116:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007582 physiological_process ARL4 GO:0007582 physiological_process GADD45A GO:0007582 physiological_process UMPK GO:0007582 physiological_process SOX14 GO:0007582 physiological_process HS2ST1 GO:0007582 physiological_process EIF3S5 GO:0007582 physiological_process TAGLN GO:0007582 physiological_process SCAP2 GO:0007582 physiological_process BIRC3 GO:0007582 physiological_process FAP GO:0007582 physiological_process AFP GO:0007582 physiological_process TMLHE GO:0007582 physiological_process TAPBP GO:0007582 physiological_process WISP2 GO:0007582 physiological_process NAP1L1 GO:0007582 physiological_process APM2 GO:0007582 physiological_process EPHA3 GO:0007582 physiological_process MAP3K5 GO:0007582 physiological_process CKMT2 GO:0007582 physiological_process GNA11 GO:0007582 physiological_process BMP2 GO:0007582 physiological_process CBR3 GO:0007582 physiological_process APG3 GO:0007582 physiological_process TK1 GO:0007582 physiological_process AMPD2 GO:0007582 physiological_process TNFRSF1A GO:0007582 physiological_process PRKAR2A GO:0007582 physiological_process PTGDS GO:0007582 physiological_process HSPA1A GO:0007582 physiological_process BFSP2 GO:0007582 physiological_process TCF8 GO:0007582 physiological_process EMP1 GO:0007582 physiological_process NFIA GO:0007582 physiological_process NARS GO:0007582 physiological_process DSCAM GO:0007582 physiological_process PTGER3 GO:0007582 physiological_process H2AFY GO:0007582 physiological_process GLA GO:0007582 physiological_process TBX3 GO:0007582 physiological_process EKI1 GO:0007582 physiological_process CRH GO:0007582 physiological_process APPBP1 GO:0007582 physiological_process INDO GO:0007582 physiological_process ATIC GO:0007582 physiological_process FOLR1 GO:0007582 physiological_process PGK1 GO:0007582 physiological_process COX6A2 GO:0007582 physiological_process SALL1 GO:0007582 physiological_process CDK8 GO:0007582 physiological_process RNPEP GO:0007582 physiological_process CDKN3 GO:0007582 physiological_process LST1 GO:0007582 physiological_process POU5F1 GO:0007582 physiological_process ASF1A GO:0007582 physiological_process ARPC1A GO:0007582 physiological_process NUDT1 GO:0007582 physiological_process CEBPD GO:0007582 physiological_process PCBD GO:0007582 physiological_process CDH16 GO:0007582 physiological_process CKAP1 GO:0007582 physiological_process PRH1

117:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007582 physiological_process MT1A GO:0007582 physiological_process H1F0 GO:0007582 physiological_process HEY1 GO:0007582 physiological_process IDI1 GO:0007582 physiological_process TESK2 GO:0007582 physiological_process ATBF1 GO:0007582 physiological_process SERPINC1 GO:0007582 physiological_process NQO1 GO:0007582 physiological_process UBA2 GO:0007582 physiological_process AASS GO:0007582 physiological_process TENR GO:0007582 physiological_process COL5A2 GO:0007582 physiological_process ATP1B1 GO:0007582 physiological_process PRND GO:0007582 physiological_process DNMT3B GO:0007582 physiological_process PRM2 GO:0007582 physiological_process ETS2 GO:0007582 physiological_process CAPZA3 GO:0007582 physiological_process FABP5 GO:0007582 physiological_process CDC42EP4 GO:0007582 physiological_process CBFB GO:0007582 physiological_process COL6A1 GO:0007582 physiological_process HMGB2 GO:0007582 physiological_process PPIC GO:0007582 physiological_process ADAMTS19 GO:0007582 physiological_process GDF10 GO:0007582 physiological_process SLC19A1 GO:0007582 physiological_process ZMPSTE24 GO:0007582 physiological_process APOA2 GO:0007582 physiological_process NANOG GO:0007582 physiological_process ARID3A GO:0007582 physiological_process PAP GO:0007582 physiological_process AGTRAP GO:0007582 physiological_process HSD3B1 GO:0007582 physiological_process ATP12A GO:0007582 physiological_process SLC17A1 GO:0007582 physiological_process COL4A6 GO:0007582 physiological_process ARNTL GO:0007582 physiological_process PDCL3 GO:0007582 physiological_process RNF128 GO:0007582 physiological_process F2 GO:0007582 physiological_process GLRX2 GO:0007582 physiological_process LOXL1 GO:0007582 physiological_process FEN1 GO:0007582 physiological_process MSN GO:0007582 physiological_process LRP10 GO:0007582 physiological_process FHL2 GO:0007582 physiological_process CBS GO:0007582 physiological_process EPAS1 GO:0007582 physiological_process SIAT4C GO:0007582 physiological_process GMPR GO:0007582 physiological_process SYCP2 GO:0007582 physiological_process LRRN3 GO:0007582 physiological_process IL27RA GO:0007582 physiological_process HSD3B2 GO:0007582 physiological_process SLC7A11 GO:0007582 physiological_process CKB GO:0007582 physiological_process MGST1 GO:0007582 physiological_process RPL29 GO:0007582 physiological_process GRIN2D GO:0007582 physiological_process PAX3

118:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007582 physiological_process C6 GO:0007582 physiological_process TCF7L2 GO:0007582 physiological_process TLE1 GO:0007582 physiological_process TBX2 GO:0007582 physiological_process PAICS GO:0007582 physiological_process CITED1 GO:0007582 physiological_process CETN3 GO:0007582 physiological_process ALDH1A3 GO:0007582 physiological_process TTR GO:0007582 physiological_process C1R GO:0007582 physiological_process MT2A GO:0007582 physiological_process BHLHB3 GO:0007582 physiological_process EMX2 GO:0007582 physiological_process COL1A1 GO:0007582 physiological_process SLCO4A1 GO:0007582 physiological_process CLC GO:0007582 physiological_process CIRBP GO:0007582 physiological_process GALC GO:0007582 physiological_process MMP11 GO:0007582 physiological_process TCEA2 GO:0007582 physiological_process COX7C GO:0007582 physiological_process TNNT3 GO:0007582 physiological_process GSTM3 GO:0007582 physiological_process ATP6V1E2 GO:0007582 physiological_process SSBP1 GO:0007582 physiological_process GGTLA1 GO:0007582 physiological_process MAPK4 GO:0007582 physiological_process LY6E GO:0007582 physiological_process FGG GO:0007582 physiological_process ID2 GO:0007582 physiological_process NSEP1 GO:0007582 physiological_process CADPS2 GO:0007582 physiological_process SUCLA2 GO:0007582 physiological_process SLC2A1 GO:0007582 physiological_process HDLBP GO:0007582 physiological_process AR GO:0007582 physiological_process GPC3 GO:0007582 physiological_process TBPL1 GO:0007582 physiological_process ELN GO:0007582 physiological_process GDF3 GO:0007582 physiological_process INSL3 GO:0007582 physiological_process TRAF5 GO:0007582 physiological_process STMN1 GO:0007582 physiological_process BAP1 GO:0007582 physiological_process LAMB2 GO:0007582 physiological_process SLCO2A1 GO:0007582 physiological_process SORL1 GO:0007582 physiological_process MDK GO:0007582 physiological_process ACE2 GO:0007582 physiological_process UPP1 GO:0042440 pigment_metabolism HEBP1 GO:0048066 pigmentation HEBP1 GO:0005886 plasma_membrane DSCAM GO:0005886 plasma_membrane PTGER3 GO:0005886 plasma_membrane HNRPM GO:0005886 plasma_membrane SCN9A GO:0005886 plasma_membrane ATP1B1 GO:0005886 plasma_membrane RRAS2 GO:0005886 plasma_membrane GGTLA1 GO:0005886 plasma_membrane MID1 GO:0005886 plasma_membrane TAPBP

119:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005886 plasma_membrane CDH17 GO:0005886 plasma_membrane LY6E GO:0005886 plasma_membrane ENPEP GO:0005886 plasma_membrane APM2 GO:0005886 plasma_membrane CKB GO:0005886 plasma_membrane CACNA1C GO:0005886 plasma_membrane SLC19A1 GO:0005886 plasma_membrane SLC2A3 GO:0005886 plasma_membrane CLEC2 GO:0005886 plasma_membrane AP2B1 GO:0005886 plasma_membrane PTPRD GO:0005886 plasma_membrane SLC2A1 GO:0005886 plasma_membrane GNA11 GO:0005886 plasma_membrane ANXA4 GO:0005886 plasma_membrane GRIN2D GO:0005886 plasma_membrane SLC17A1 GO:0005886 plasma_membrane BAMBI GO:0005886 plasma_membrane MS4A2 GO:0005886 plasma_membrane PTPRK GO:0005886 plasma_membrane GPC5 GO:0005886 plasma_membrane GPC3 GO:0005886 plasma_membrane TNFRSF1A GO:0005886 plasma_membrane CALB2 GO:0005886 plasma_membrane VLDLR GO:0005886 plasma_membrane PTPRR GO:0005886 plasma_membrane SLC19A2 GO:0005886 plasma_membrane ITGBL1 GO:0005886 plasma_membrane PRNP GO:0005886 plasma_membrane SLCO2A1 GO:0005886 plasma_membrane MSN GO:0005886 plasma_membrane LRP10 GO:0005886 plasma_membrane PMP22 GO:0005886 plasma_membrane CLC GO:0005886 plasma_membrane ROR1 GO:0008243 plasminogen_activator_activity PLAT GO:0009536 plastid MAPK4 GO:0009536 plastid RPS8 GO:0009536 plastid GGPS1 GO:0009657 plastid_organization_and_biogenesis APG3 GO:0009547 plastid_ribosome RPS8 GO:0000312 plastid_small_ribosomal_subunit RPS8 GO:0009532 plastid_stroma RPS8 GO:0004649 poly(ADP-ribose)_glycohydrolase_activity PARG GO:0015203 polyamine_transporter_activity SLC7A11 GO:0009241 polyisoprenoid_biosynthesis IDI1 GO:0016096 polyisoprenoid_metabolism IDI1 GO:0019751 polyol_metabolism GK2 GO:0000271 polysaccharide_biosynthesis GNE GO:0000271 polysaccharide_biosynthesis HS2ST1 GO:0005976 polysaccharide_metabolism GNE GO:0005976 polysaccharide_metabolism HS2ST1 GO:0015288 porin_activity ROPN1 GO:0006778 porphyrin_metabolism HEBP1 GO:0015291 porter_activity SLC19A2 GO:0015291 porter_activity SLC2A1 GO:0015291 porter_activity SLC17A1 GO:0015291 porter_activity CDH17 GO:0015291 porter_activity SLC7A11 GO:0015291 porter_activity SLC19A1 GO:0015291 porter_activity SLC2A3 GO:0015291 porter_activity TBPL1

120:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0045768 positive_regulation_of_anti-apoptosis PRKAA1 GO:0043065 positive_regulation_of_apoptosis INHA GO:0043065 positive_regulation_of_apoptosis CASP7 GO:0043065 positive_regulation_of_apoptosis APPBP1 GO:0009891 positive_regulation_of_biosynthesis PRKAA1 GO:0045913 positive_regulation_of_carbohydrate_metabolism PRKAA1 GO:0008284 positive_regulation_of_cell_proliferation ID2 GO:0008284 positive_regulation_of_cell_proliferation TRAF5 GO:0045542 positive_regulation_of_cholesterol_biosynthesis PRKAA1 GO:0045921 positive_regulation_of_exocytosis CADPS2 GO:0045923 positive_regulation_of_fatty_acid_metabolism PRKAA1 GO:0046321 positive_regulation_of_fatty_acid_oxidation PRKAA1 GO:0046881 positive_regulation_of_follicle-stimulating_hormone_secretion INHA GO:0045722 positive_regulation_of_gluconeogenesis PRKAA1 GO:0046326 positive_regulation_of_glucose_import PRKAA1 GO:0046887 positive_regulation_of_hormone_secretion INHA GO:0045834 positive_regulation_of_lipid_metabolism PRKAA1 GO:0009893 positive_regulation_of_metabolism PRKAA1 GO:0009893 positive_regulation_of_metabolism CBFB GO:0009893 positive_regulation_of_metabolism POU5F1 GO:0045935 positive_regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_meCBFB GO:0045935 positive_regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_mePOU5F1 GO:0043119 positive_regulation_of_physiological_process INHA GO:0043068 positive_regulation_of_programmed_cell_death INHA GO:0043068 positive_regulation_of_programmed_cell_death CASP7 GO:0043068 positive_regulation_of_programmed_cell_death APPBP1 GO:0051047 positive_regulation_of_secretion INHA GO:0045941 positive_regulation_of_transcription CBFB GO:0045941 positive_regulation_of_transcription POU5F1 GO:0045893 positive_regulation_of_transcription,_DNA-dependent CBFB GO:0045893 positive_regulation_of_transcription,_DNA-dependent POU5F1 GO:0045944 positive_regulation_of_transcription_from_Pol_II_promoter CBFB GO:0051050 positive_regulation_of_transport PRKAA1 GO:0051050 positive_regulation_of_transport CADPS2 GO:0009791 post-embryonic_development AFP GO:0009791 post-embryonic_development INHA GO:0045211 postsynaptic_membrane CADPS2 GO:0006620 posttranslational_membrane_targeting FOLR1 GO:0006813 potassium_ion_transport ATP12A GO:0006813 potassium_ion_transport ATP1B1 GO:0015405 P-P-bond-hydrolysis-driven_transporter_activity ATP12A GO:0015405 P-P-bond-hydrolysis-driven_transporter_activity ATP1B1 GO:0015405 P-P-bond-hydrolysis-driven_transporter_activity ATP6V1E2 GO:0030327 prenylated_protein_catabolism ZMPSTE24 GO:0004727 prenylated_protein_tyrosine_phosphatase_activity PTPRR GO:0004659 prenyltransferase_activity GGPS1 GO:0042734 presynaptic_membrane CADPS2 GO:0015399 primary_active_transporter_activity ATP12A GO:0015399 primary_active_transporter_activity NDUFB9 GO:0015399 primary_active_transporter_activity COX6A2 GO:0015399 primary_active_transporter_activity COX7C GO:0015399 primary_active_transporter_activity ATP1B1 GO:0015399 primary_active_transporter_activity ATP6V1E2 GO:0042448 progesterone_metabolism AFP GO:0012501 programmed_cell_death PRKAA1 GO:0012501 programmed_cell_death AHR GO:0012501 programmed_cell_death INHA GO:0012501 programmed_cell_death CUL1 GO:0012501 programmed_cell_death TNFRSF1A GO:0012501 programmed_cell_death BIRC3 GO:0012501 programmed_cell_death CASP7

121:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0012501 programmed_cell_death MAP3K5 GO:0012501 programmed_cell_death APPBP1 GO:0012501 programmed_cell_death IGF1 GO:0012501 programmed_cell_death TRAF5 GO:0004287 prolyl_oligopeptidase_activity FAP GO:0004287 prolyl_oligopeptidase_activity APEH GO:0001516 prostaglandin_biosynthesis PTGDS GO:0004957 prostaglandin_E_receptor_activity PTGER3 GO:0006693 prostaglandin_metabolism PTGES GO:0006693 prostaglandin_metabolism TNFRSF1A GO:0006693 prostaglandin_metabolism PTGDS GO:0004955 prostaglandin_receptor_activity PTGER3 GO:0015732 prostaglandin_transport SLCO2A1 GO:0015132 prostaglandin_transporter_activity SLCO2A1 GO:0004667 prostaglandin-D_synthase_activity PTGES GO:0004667 prostaglandin-D_synthase_activity PTGDS GO:0046457 prostanoid_biosynthesis PTGDS GO:0006692 prostanoid_metabolism PTGES GO:0006692 prostanoid_metabolism TNFRSF1A GO:0006692 prostanoid_metabolism PTGDS GO:0004954 prostanoid_receptor_activity PTGER3 GO:0030414 protease_inhibitor_activity AMBP GO:0030414 protease_inhibitor_activity TIMP4 GO:0030414 protease_inhibitor_activity SERPINC1 GO:0030414 protease_inhibitor_activity PAPLN GO:0006471 protein_amino_acid_ADP-ribosylation ART3 GO:0006471 protein_amino_acid_ADP-ribosylation GNA11 GO:0006470 protein_amino_acid_dephosphorylation DUSP6 GO:0006470 protein_amino_acid_dephosphorylation PTPRK GO:0006470 protein_amino_acid_dephosphorylation PPP6C GO:0006470 protein_amino_acid_dephosphorylation PTPN13 GO:0006470 protein_amino_acid_dephosphorylation PTPRR GO:0006486 protein_amino_acid_glycosylation SIAT4C GO:0006468 protein_amino_acid_phosphorylation PRKAA1 GO:0006468 protein_amino_acid_phosphorylation PRKAR2B GO:0006468 protein_amino_acid_phosphorylation GADD45A GO:0006468 protein_amino_acid_phosphorylation PRKAR2A GO:0006468 protein_amino_acid_phosphorylation OCA2 GO:0006468 protein_amino_acid_phosphorylation TESK2 GO:0006468 protein_amino_acid_phosphorylation MAPK4 GO:0006468 protein_amino_acid_phosphorylation MSN GO:0006468 protein_amino_acid_phosphorylation CCT2 GO:0006468 protein_amino_acid_phosphorylation CDK8 GO:0006468 protein_amino_acid_phosphorylation EPHA3 GO:0006468 protein_amino_acid_phosphorylation ROR1 GO:0006468 protein_amino_acid_phosphorylation MAP3K5 GO:0005515 protein_binding SPAG5 GO:0005515 protein_binding INHA GO:0005515 protein_binding TLE4 GO:0005515 protein_binding PTGER3 GO:0005515 protein_binding TPD52L1 GO:0005515 protein_binding STX6 GO:0005515 protein_binding IL27RA GO:0005515 protein_binding PAX5 GO:0005515 protein_binding ASF1A GO:0005515 protein_binding AP2B1 GO:0005515 protein_binding AHR GO:0005515 protein_binding ARPC1A GO:0005515 protein_binding CEBPD GO:0005515 protein_binding CDH16 GO:0005515 protein_binding AES

122:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005515 protein_binding PCBD GO:0005515 protein_binding DDX20 GO:0005515 protein_binding PLS3 GO:0005515 protein_binding CAPZB GO:0005515 protein_binding TLE1 GO:0005515 protein_binding TCF7L2 GO:0005515 protein_binding PTPN13 GO:0005515 protein_binding GNB2L1 GO:0005515 protein_binding PTPRR GO:0005515 protein_binding HEY1 GO:0005515 protein_binding ITGBL1 GO:0005515 protein_binding DNMT3L GO:0005515 protein_binding TBX2 GO:0005515 protein_binding CUL1 GO:0005515 protein_binding BHLHB3 GO:0005515 protein_binding CX3CL1 GO:0005515 protein_binding BAZ1B GO:0005515 protein_binding DKK1 GO:0005515 protein_binding COL6A2 GO:0005515 protein_binding VTN GO:0005515 protein_binding CHRDL2 GO:0005515 protein_binding GADD45A GO:0005515 protein_binding THBS2 GO:0005515 protein_binding BIRC3 GO:0005515 protein_binding DNMT3B GO:0005515 protein_binding CAPZA3 GO:0005515 protein_binding CDC42EP4 GO:0005515 protein_binding CBFB GO:0005515 protein_binding COL6A1 GO:0005515 protein_binding CDH17 GO:0005515 protein_binding SRGAP2 GO:0005515 protein_binding WISP2 GO:0005515 protein_binding APM2 GO:0005515 protein_binding ID2 GO:0005515 protein_binding MAP3K5 GO:0005515 protein_binding CADPS2 GO:0005515 protein_binding MYH11 GO:0005515 protein_binding TERF1 GO:0005515 protein_binding TGFBI GO:0005515 protein_binding BMP2 GO:0005515 protein_binding MS4A2 GO:0005515 protein_binding ARNTL GO:0005515 protein_binding AR GO:0005515 protein_binding TIP120B GO:0005515 protein_binding TNFRSF1A GO:0005515 protein_binding STMN1 GO:0005515 protein_binding FN1 GO:0005515 protein_binding BAP1 GO:0005515 protein_binding LAMB2 GO:0005515 protein_binding LRP10 GO:0005515 protein_binding FHL2 GO:0006412 protein_biosynthesis RPL29 GO:0006412 protein_biosynthesis PRKAA1 GO:0006412 protein_biosynthesis INHA GO:0006412 protein_biosynthesis NARS GO:0006412 protein_biosynthesis RPL18A GO:0006412 protein_biosynthesis GADD45A GO:0006412 protein_biosynthesis RNF128 GO:0006412 protein_biosynthesis RPL28 GO:0006412 protein_biosynthesis CDH16 GO:0006412 protein_biosynthesis EIF3S5

123:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006412 protein_biosynthesis SIAT4C GO:0006412 protein_biosynthesis WARS GO:0006412 protein_biosynthesis RPS8 GO:0030163 protein_catabolism SPAG5 GO:0030163 protein_catabolism MMP11 GO:0030163 protein_catabolism UBA2 GO:0030163 protein_catabolism PLAT GO:0030163 protein_catabolism TENR GO:0030163 protein_catabolism ARNTL GO:0030163 protein_catabolism RNF128 GO:0030163 protein_catabolism FAP GO:0030163 protein_catabolism APEH GO:0030163 protein_catabolism F2 GO:0030163 protein_catabolism COL6A1 GO:0030163 protein_catabolism BAP1 GO:0030163 protein_catabolism C1R GO:0030163 protein_catabolism ENPEP GO:0030163 protein_catabolism ADAMTS19 GO:0030163 protein_catabolism ACE2 GO:0030163 protein_catabolism ZMPSTE24 GO:0030163 protein_catabolism RNPEP GO:0030163 protein_catabolism CASP7 GO:0016579 protein_deubiquitination BAP1 GO:0046983 protein_dimerization_activity CEBPD GO:0006457 protein_folding PPIC GO:0006457 protein_folding CCT2 GO:0006457 protein_folding BAG5 GO:0042803 protein_homodimerization_activity CEBPD GO:0030295 protein_kinase_activator_activity PRKAA1 GO:0004672 protein_kinase_activity PRKAA1 GO:0004672 protein_kinase_activity PRKAR2A GO:0004672 protein_kinase_activity OCA2 GO:0004672 protein_kinase_activity TESK2 GO:0004672 protein_kinase_activity MAPK4 GO:0004672 protein_kinase_activity PGK1 GO:0004672 protein_kinase_activity MSN GO:0004672 protein_kinase_activity CCT2 GO:0004672 protein_kinase_activity EPHA3 GO:0004672 protein_kinase_activity CDK8 GO:0004672 protein_kinase_activity MAP3K5 GO:0004672 protein_kinase_activity ROR1 GO:0004672 protein_kinase_activity NRBP GO:0019901 protein_kinase_binding GNB2L1 GO:0019901 protein_kinase_binding PTPRR GO:0007205 protein_kinase_C_activation GNB2L1 GO:0005080 protein_kinase_C_binding GNB2L1 GO:0007243 protein_kinase_cascade LRRN3 GO:0007243 protein_kinase_cascade PRKAA1 GO:0007243 protein_kinase_cascade MSN GO:0007243 protein_kinase_cascade NRBP GO:0004682 protein_kinase_CK2_activity MAPK4 GO:0019887 protein_kinase_regulator_activity SPA17 GO:0019887 protein_kinase_regulator_activity PRKAA1 GO:0019887 protein_kinase_regulator_activity PRKAR2B GO:0019887 protein_kinase_regulator_activity PRKAR2A GO:0019538 protein_metabolism SPAG5 GO:0019538 protein_metabolism DUSP6 GO:0019538 protein_metabolism INHA GO:0019538 protein_metabolism PRKAR2B GO:0019538 protein_metabolism NARS GO:0019538 protein_metabolism RPL18A

124:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0019538 protein_metabolism RPL28 GO:0019538 protein_metabolism SIAT4C GO:0019538 protein_metabolism OCA2 GO:0019538 protein_metabolism FOLR1 GO:0019538 protein_metabolism ENPEP GO:0019538 protein_metabolism CDK8 GO:0019538 protein_metabolism RNPEP GO:0019538 protein_metabolism CASP7 GO:0019538 protein_metabolism POU5F1 GO:0019538 protein_metabolism RPL29 GO:0019538 protein_metabolism PLAT GO:0019538 protein_metabolism PTPRK GO:0019538 protein_metabolism CDH16 GO:0019538 protein_metabolism PTPN13 GO:0019538 protein_metabolism PTPRR GO:0019538 protein_metabolism ART3 GO:0019538 protein_metabolism TESK2 GO:0019538 protein_metabolism APOE GO:0019538 protein_metabolism C1R GO:0019538 protein_metabolism CCT2 GO:0019538 protein_metabolism UBA2 GO:0019538 protein_metabolism MMP11 GO:0019538 protein_metabolism PRKAA1 GO:0019538 protein_metabolism TENR GO:0019538 protein_metabolism GADD45A GO:0019538 protein_metabolism HS2ST1 GO:0019538 protein_metabolism EIF3S5 GO:0019538 protein_metabolism BAG5 GO:0019538 protein_metabolism FAP GO:0019538 protein_metabolism APEH GO:0019538 protein_metabolism MAPK4 GO:0019538 protein_metabolism COL6A1 GO:0019538 protein_metabolism RPS8 GO:0019538 protein_metabolism WARS GO:0019538 protein_metabolism PPIC GO:0019538 protein_metabolism PPP6C GO:0019538 protein_metabolism ADAMTS19 GO:0019538 protein_metabolism ZMPSTE24 GO:0019538 protein_metabolism APOA2 GO:0019538 protein_metabolism EPHA3 GO:0019538 protein_metabolism MAP3K5 GO:0019538 protein_metabolism GNA11 GO:0019538 protein_metabolism ARNTL GO:0019538 protein_metabolism RNF128 GO:0019538 protein_metabolism PRKAR2A GO:0019538 protein_metabolism F2 GO:0019538 protein_metabolism LOXL1 GO:0019538 protein_metabolism BAP1 GO:0019538 protein_metabolism MSN GO:0019538 protein_metabolism ACE2 GO:0019538 protein_metabolism ROR1 GO:0006464 protein_modification UBA2 GO:0006464 protein_modification DUSP6 GO:0006464 protein_modification PRKAA1 GO:0006464 protein_modification GNA11 GO:0006464 protein_modification PRKAR2B GO:0006464 protein_modification PTPRK GO:0006464 protein_modification GADD45A GO:0006464 protein_modification SIAT4C GO:0006464 protein_modification PTPN13 GO:0006464 protein_modification PRKAR2A

125:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006464 protein_modification PTPRR GO:0006464 protein_modification ART3 GO:0006464 protein_modification OCA2 GO:0006464 protein_modification TESK2 GO:0006464 protein_modification LOXL1 GO:0006464 protein_modification MAPK4 GO:0006464 protein_modification BAP1 GO:0006464 protein_modification MSN GO:0006464 protein_modification PPP6C GO:0006464 protein_modification CCT2 GO:0006464 protein_modification EPHA3 GO:0006464 protein_modification CDK8 GO:0006464 protein_modification MAP3K5 GO:0006464 protein_modification ROR1 GO:0000163 protein_phosphatase_type_1_activity DUSP6 GO:0000163 protein_phosphatase_type_1_activity PPP6C GO:0000158 protein_phosphatase_type_2A_activity DUSP6 GO:0000158 protein_phosphatase_type_2A_activity PPP6C GO:0030357 protein_phosphatase_type_2B_activity DUSP6 GO:0015071 protein_phosphatase_type_2C_activity DUSP6 GO:0015071 protein_phosphatase_type_2C_activity PPP6C GO:0042802 protein_self_binding CEBPD GO:0004674 protein_serine/threonine_kinase_activity PRKAA1 GO:0004674 protein_serine/threonine_kinase_activity TESK2 GO:0004674 protein_serine/threonine_kinase_activity MAPK4 GO:0004674 protein_serine/threonine_kinase_activity PGK1 GO:0004674 protein_serine/threonine_kinase_activity MSN GO:0004674 protein_serine/threonine_kinase_activity PRKAR2A GO:0004674 protein_serine/threonine_kinase_activity EPHA3 GO:0004674 protein_serine/threonine_kinase_activity CDK8 GO:0004674 protein_serine/threonine_kinase_activity MAP3K5 GO:0004674 protein_serine/threonine_kinase_activity ROR1 GO:0004674 protein_serine/threonine_kinase_activity NRBP GO:0004722 protein_serine/threonine_phosphatase_activity DUSP6 GO:0004722 protein_serine/threonine_phosphatase_activity PPP6C GO:0004722 protein_serine/threonine_phosphatase_activity CDKN3 GO:0016925 protein_sumoylation UBA2 GO:0006605 protein_targeting FOLR1 GO:0006605 protein_targeting ARNTL GO:0006605 protein_targeting POU5F1 GO:0015031 protein_transport FOLR1 GO:0015031 protein_transport ARNTL GO:0015031 protein_transport COPE GO:0015031 protein_transport ARL4 GO:0015031 protein_transport SORL1 GO:0015031 protein_transport APM2 GO:0015031 protein_transport STX6 GO:0015031 protein_transport CLC GO:0015031 protein_transport POU5F1 GO:0008565 protein_transporter_activity COPE GO:0008565 protein_transporter_activity SORL1 GO:0008565 protein_transporter_activity STX6 GO:0008138 protein_tyrosine/serine/threonine_phosphatase_activity DUSP6 GO:0004725 protein_tyrosine_phosphatase_activity PTPRD GO:0004725 protein_tyrosine_phosphatase_activity PTPRK GO:0004725 protein_tyrosine_phosphatase_activity PTPN13 GO:0004725 protein_tyrosine_phosphatase_activity CDKN3 GO:0004725 protein_tyrosine_phosphatase_activity PTPRR GO:0006129 protein-disulfide_reduction NDUFB9 GO:0045047 protein-ER_targeting FOLR1 GO:0004720 protein-lysine_6-oxidase_activity LOXL1

126:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006612 protein-membrane_targeting FOLR1 GO:0006606 protein-nucleus_import ARNTL GO:0000060 protein-nucleus_import,_translocation ARNTL GO:0004713 protein-tyrosine_kinase_activity PRKAA1 GO:0004713 protein-tyrosine_kinase_activity TESK2 GO:0004713 protein-tyrosine_kinase_activity MAPK4 GO:0004713 protein-tyrosine_kinase_activity EPHA3 GO:0004713 protein-tyrosine_kinase_activity MAP3K5 GO:0004713 protein-tyrosine_kinase_activity ROR1 GO:0030166 proteoglycan_biosynthesis HS2ST1 GO:0006029 proteoglycan_metabolism HS2ST1 GO:0006508 proteolysis_and_peptidolysis SPAG5 GO:0006508 proteolysis_and_peptidolysis MMP11 GO:0006508 proteolysis_and_peptidolysis UBA2 GO:0006508 proteolysis_and_peptidolysis PLAT GO:0006508 proteolysis_and_peptidolysis TENR GO:0006508 proteolysis_and_peptidolysis RNF128 GO:0006508 proteolysis_and_peptidolysis FAP GO:0006508 proteolysis_and_peptidolysis APEH GO:0006508 proteolysis_and_peptidolysis F2 GO:0006508 proteolysis_and_peptidolysis COL6A1 GO:0006508 proteolysis_and_peptidolysis BAP1 GO:0006508 proteolysis_and_peptidolysis ENPEP GO:0006508 proteolysis_and_peptidolysis C1R GO:0006508 proteolysis_and_peptidolysis ADAMTS19 GO:0006508 proteolysis_and_peptidolysis ACE2 GO:0006508 proteolysis_and_peptidolysis RNPEP GO:0006508 proteolysis_and_peptidolysis CASP7 GO:0015992 proton_transport ATP12A GO:0015992 proton_transport ATP6V1E2 GO:0005427 proton-dependent_oligopeptide_transporter_activity CDH17 GO:0045259 proton-transporting_ATP_synthase_complex ATP6V1E2 GO:0005753 proton-transporting_ATP_synthase_complex_(sensu_Eukarya) ATP6V1E2 GO:0016469 proton-transporting_two-sector_ATPase_complex ATP6V1E2 GO:0042559 pteridine_and_derivative_biosynthesis PCBD GO:0042558 pteridine_and_derivative_metabolism FOLR1 GO:0042558 pteridine_and_derivative_metabolism PCBD GO:0006144 purine_base_metabolism AMPD2 GO:0009217 purine_deoxyribonucleoside_triphosphate_catabolism NUDT1 GO:0009215 purine_deoxyribonucleoside_triphosphate_metabolism NUDT1 GO:0009155 purine_deoxyribonucleotide_catabolism NUDT1 GO:0009151 purine_deoxyribonucleotide_metabolism NUDT1 GO:0009127 purine_nucleoside_monophosphate_biosynthesis PAICS GO:0009127 purine_nucleoside_monophosphate_biosynthesis AMPD2 GO:0009128 purine_nucleoside_monophosphate_catabolism GMPR2 GO:0009126 purine_nucleoside_monophosphate_metabolism PAICS GO:0009126 purine_nucleoside_monophosphate_metabolism AMPD2 GO:0009126 purine_nucleoside_monophosphate_metabolism GMPR2 GO:0009145 purine_nucleoside_triphosphate_biosynthesis ATP6V1E2 GO:0009146 purine_nucleoside_triphosphate_catabolism NUDT1 GO:0009144 purine_nucleoside_triphosphate_metabolism NUDT1 GO:0009144 purine_nucleoside_triphosphate_metabolism ATP6V1E2 GO:0017076 purine_nucleotide_binding PRKAA1 GO:0017076 purine_nucleotide_binding PRKAR2B GO:0017076 purine_nucleotide_binding GK2 GO:0017076 purine_nucleotide_binding NARS GO:0017076 purine_nucleotide_binding ARL4 GO:0017076 purine_nucleotide_binding UMPK GO:0017076 purine_nucleotide_binding DRG1 GO:0017076 purine_nucleotide_binding RRAS2 GO:0017076 purine_nucleotide_binding OCA2

127:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0017076 purine_nucleotide_binding MAPK4 GO:0017076 purine_nucleotide_binding WARS GO:0017076 purine_nucleotide_binding ITM2B GO:0017076 purine_nucleotide_binding EPHA3 GO:0017076 purine_nucleotide_binding CDK8 GO:0017076 purine_nucleotide_binding NRBP GO:0017076 purine_nucleotide_binding MAP3K5 GO:0017076 purine_nucleotide_binding MYH11 GO:0017076 purine_nucleotide_binding ATP12A GO:0017076 purine_nucleotide_binding GNA11 GO:0017076 purine_nucleotide_binding SLC2A1 GO:0017076 purine_nucleotide_binding GNAI1 GO:0017076 purine_nucleotide_binding CDH16 GO:0017076 purine_nucleotide_binding TK1 GO:0017076 purine_nucleotide_binding DDX20 GO:0017076 purine_nucleotide_binding PRKAR2A GO:0017076 purine_nucleotide_binding DDX25 GO:0017076 purine_nucleotide_binding TESK2 GO:0017076 purine_nucleotide_binding GNE GO:0017076 purine_nucleotide_binding HSPA1A GO:0017076 purine_nucleotide_binding CCT2 GO:0017076 purine_nucleotide_binding DHX35 GO:0017076 purine_nucleotide_binding ROR1 GO:0006164 purine_nucleotide_biosynthesis ATIC GO:0006164 purine_nucleotide_biosynthesis PAICS GO:0006164 purine_nucleotide_biosynthesis AMPD2 GO:0006164 purine_nucleotide_biosynthesis ATP6V1E2 GO:0006195 purine_nucleotide_catabolism NUDT1 GO:0006195 purine_nucleotide_catabolism GMPR2 GO:0006163 purine_nucleotide_metabolism ATIC GO:0006163 purine_nucleotide_metabolism NUDT1 GO:0006163 purine_nucleotide_metabolism PAICS GO:0006163 purine_nucleotide_metabolism AMPD2 GO:0006163 purine_nucleotide_metabolism GMPR2 GO:0006163 purine_nucleotide_metabolism ATP6V1E2 GO:0009168 purine_ribonucleoside_monophosphate_biosynthesis PAICS GO:0009168 purine_ribonucleoside_monophosphate_biosynthesis AMPD2 GO:0009169 purine_ribonucleoside_monophosphate_catabolism GMPR2 GO:0009167 purine_ribonucleoside_monophosphate_metabolism PAICS GO:0009167 purine_ribonucleoside_monophosphate_metabolism AMPD2 GO:0009167 purine_ribonucleoside_monophosphate_metabolism GMPR2 GO:0009206 purine_ribonucleoside_triphosphate_biosynthesis ATP6V1E2 GO:0009205 purine_ribonucleoside_triphosphate_metabolism ATP6V1E2 GO:0009152 purine_ribonucleotide_biosynthesis PAICS GO:0009152 purine_ribonucleotide_biosynthesis AMPD2 GO:0009152 purine_ribonucleotide_biosynthesis ATP6V1E2 GO:0009154 purine_ribonucleotide_catabolism GMPR2 GO:0009150 purine_ribonucleotide_metabolism PAICS GO:0009150 purine_ribonucleotide_metabolism AMPD2 GO:0009150 purine_ribonucleotide_metabolism GMPR2 GO:0009150 purine_ribonucleotide_metabolism ATP6V1E2 GO:0001614 purinergic_nucleotide_receptor_activity ADORA2B GO:0045028 purinergic_nucleotide_receptor_activity,_G-protein_coupled ADORA2B GO:0030170 pyridoxal_phosphate_binding PROSC GO:0046125 pyrimidine_deoxyribonucleoside_metabolism TBPL1 GO:0009212 pyrimidine_deoxyribonucleoside_triphosphate_biosynthesis TBPL1 GO:0009211 pyrimidine_deoxyribonucleoside_triphosphate_metabolism TBPL1 GO:0009221 pyrimidine_deoxyribonucleotide_biosynthesis TBPL1 GO:0009219 pyrimidine_deoxyribonucleotide_metabolism TBPL1 GO:0006213 pyrimidine_nucleoside_metabolism TBPL1 GO:0009148 pyrimidine_nucleoside_triphosphate_biosynthesis TBPL1

128:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0009147 pyrimidine_nucleoside_triphosphate_metabolism TBPL1 GO:0006221 pyrimidine_nucleotide_biosynthesis TBPL1 GO:0006220 pyrimidine_nucleotide_metabolism TBPL1 GO:0016854 racemase_and_epimerase_activity GNE GO:0016854 racemase_and_epimerase_activity PROSC GO:0016855 racemase_and_epimerase_activity,_acting_on_amino_acids_and_derivatives PROSC GO:0016857 racemase_and_epimerase_activity,_acting_on_carbohydrates_and_derivatives GNE GO:0007265 RAS_protein_signal_transduction RRAS2 GO:0004872 receptor_activity SEMA4C GO:0004872 receptor_activity GPC4 GO:0004872 receptor_activity DSCAM GO:0004872 receptor_activity PTGER3 GO:0004872 receptor_activity HNRPM GO:0004872 receptor_activity FOLR1 GO:0004872 receptor_activity IL22RA1 GO:0004872 receptor_activity IL27RA GO:0004872 receptor_activity TLR8 GO:0004872 receptor_activity EPHA3 GO:0004872 receptor_activity CLEC2 GO:0004872 receptor_activity NRBP GO:0004872 receptor_activity AGTRAP GO:0004872 receptor_activity FZD7 GO:0004872 receptor_activity AHR GO:0004872 receptor_activity PTPRD GO:0004872 receptor_activity MS4A2 GO:0004872 receptor_activity GRIN2D GO:0004872 receptor_activity PTPRK GO:0004872 receptor_activity IFNGR2 GO:0004872 receptor_activity AR GO:0004872 receptor_activity FZD4 GO:0004872 receptor_activity SEMA5B GO:0004872 receptor_activity BRS3 GO:0004872 receptor_activity PTPN13 GO:0004872 receptor_activity TNFRSF1A GO:0004872 receptor_activity PRKAR2A GO:0004872 receptor_activity NR2F1 GO:0004872 receptor_activity FEM1B GO:0004872 receptor_activity VLDLR GO:0004872 receptor_activity GPR6 GO:0004872 receptor_activity INSL3 GO:0004872 receptor_activity PTPRR GO:0004872 receptor_activity SLC19A2 GO:0004872 receptor_activity GPR45 GO:0004872 receptor_activity SORL1 GO:0004872 receptor_activity ADORA2B GO:0004872 receptor_activity LRP10 GO:0004872 receptor_activity SCARB1 GO:0004872 receptor_activity ROR1 GO:0004872 receptor_activity CCKBR GO:0005102 receptor_binding BMP2 GO:0005102 receptor_binding S100A11 GO:0005102 receptor_binding INHA GO:0005102 receptor_binding ANGPTL1 GO:0005102 receptor_binding TNFRSF1A GO:0005102 receptor_binding HDGF GO:0005102 receptor_binding OGN GO:0005102 receptor_binding GAL GO:0005102 receptor_binding CRH GO:0005102 receptor_binding GDF3 GO:0005102 receptor_binding INSL3 GO:0005102 receptor_binding GRB14

129:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005102 receptor_binding CART GO:0005102 receptor_binding IL27RA GO:0005102 receptor_binding CGA GO:0005102 receptor_binding CX3CL1 GO:0005102 receptor_binding PDZK1 GO:0005102 receptor_binding GDF10 GO:0005102 receptor_binding MDK GO:0005102 receptor_binding IGF1 GO:0006898 receptor_mediated_endocytosis CLC GO:0005057 receptor_signaling_protein_activity GRB14 GO:0005057 receptor_signaling_protein_activity MAPK4 GO:0005057 receptor_signaling_protein_activity MSN GO:0005057 receptor_signaling_protein_activity CDK8 GO:0004702 receptor_signaling_protein_serine/threonine_kinase_activity MAPK4 GO:0004702 receptor_signaling_protein_serine/threonine_kinase_activity MSN GO:0004702 receptor_signaling_protein_serine/threonine_kinase_activity CDK8 GO:0008518 reduced_folate_carrier_activity SLC19A2 GO:0008518 reduced_folate_carrier_activity SLC19A1 GO:0030832 regulation_of_actin_filament_length ELN GO:0030833 regulation_of_actin_filament_polymerization ELN GO:0008064 regulation_of_actin_polymerization_and/or_depolymerization ELN GO:0001508 regulation_of_action_potential GNA11 GO:0045765 regulation_of_angiogenesis ADORA2B GO:0045767 regulation_of_anti-apoptosis PRKAA1 GO:0042981 regulation_of_apoptosis PRKAA1 GO:0042981 regulation_of_apoptosis INHA GO:0042981 regulation_of_apoptosis BIRC3 GO:0042981 regulation_of_apoptosis CASP7 GO:0042981 regulation_of_apoptosis APPBP1 GO:0042981 regulation_of_apoptosis IGF1 GO:0050885 regulation_of_balance NR2F1 GO:0045577 regulation_of_B-cell_differentiation INHA GO:0050795 regulation_of_behavior PTGDS GO:0050789 regulation_of_biological_process INHA GO:0050789 regulation_of_biological_process TLE4 GO:0050789 regulation_of_biological_process EPAS1 GO:0050789 regulation_of_biological_process TBX3 GO:0050789 regulation_of_biological_process GAL GO:0050789 regulation_of_biological_process APPBP1 GO:0050789 regulation_of_biological_process SOX30 GO:0050789 regulation_of_biological_process MID1 GO:0050789 regulation_of_biological_process MTA3 GO:0050789 regulation_of_biological_process TRPS1 GO:0050789 regulation_of_biological_process SALL1 GO:0050789 regulation_of_biological_process PAX5 GO:0050789 regulation_of_biological_process CASP7 GO:0050789 regulation_of_biological_process POU5F1 GO:0050789 regulation_of_biological_process AHR GO:0050789 regulation_of_biological_process PPP1R12B GO:0050789 regulation_of_biological_process BAMBI GO:0050789 regulation_of_biological_process PAX3 GO:0050789 regulation_of_biological_process CEBPD GO:0050789 regulation_of_biological_process AES GO:0050789 regulation_of_biological_process DDX20 GO:0050789 regulation_of_biological_process TCF7L2 GO:0050789 regulation_of_biological_process TLE1 GO:0050789 regulation_of_biological_process NR2F1 GO:0050789 regulation_of_biological_process FEM1B GO:0050789 regulation_of_biological_process HEY1 GO:0050789 regulation_of_biological_process DNMT3L GO:0050789 regulation_of_biological_process SIRT7

130:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0050789 regulation_of_biological_process TBX2 GO:0050789 regulation_of_biological_process CITED1 GO:0050789 regulation_of_biological_process SHOX2 GO:0050789 regulation_of_biological_process BHLHB3 GO:0050789 regulation_of_biological_process ATBF1 GO:0050789 regulation_of_biological_process EMX2 GO:0050789 regulation_of_biological_process BAZ1B GO:0050789 regulation_of_biological_process DKK1 GO:0050789 regulation_of_biological_process PRKAA1 GO:0050789 regulation_of_biological_process TCEA2 GO:0050789 regulation_of_biological_process CHRDL2 GO:0050789 regulation_of_biological_process GADD45A GO:0050789 regulation_of_biological_process SOX14 GO:0050789 regulation_of_biological_process KLF12 GO:0050789 regulation_of_biological_process TLX2 GO:0050789 regulation_of_biological_process SCAP2 GO:0050789 regulation_of_biological_process BIRC3 GO:0050789 regulation_of_biological_process MLL GO:0050789 regulation_of_biological_process DNMT3B GO:0050789 regulation_of_biological_process APEH GO:0050789 regulation_of_biological_process TM4SF3 GO:0050789 regulation_of_biological_process ETS2 GO:0050789 regulation_of_biological_process CBFB GO:0050789 regulation_of_biological_process HMGB2 GO:0050789 regulation_of_biological_process WISP2 GO:0050789 regulation_of_biological_process HESX1 GO:0050789 regulation_of_biological_process PPP6C GO:0050789 regulation_of_biological_process ID2 GO:0050789 regulation_of_biological_process ARID3A GO:0050789 regulation_of_biological_process NSEP1 GO:0050789 regulation_of_biological_process AGTRAP GO:0050789 regulation_of_biological_process CADPS2 GO:0050789 regulation_of_biological_process HNF3B GO:0050789 regulation_of_biological_process ARNTL GO:0050789 regulation_of_biological_process RNF128 GO:0050789 regulation_of_biological_process AR GO:0050789 regulation_of_biological_process GPC3 GO:0050789 regulation_of_biological_process PTGDS GO:0050789 regulation_of_biological_process TRAF5 GO:0050789 regulation_of_biological_process BAP1 GO:0050789 regulation_of_biological_process FOXA1 GO:0050789 regulation_of_biological_process MSN GO:0050789 regulation_of_biological_process SPRY1 GO:0050789 regulation_of_biological_process TCF8 GO:0050789 regulation_of_biological_process ACE2 GO:0050789 regulation_of_biological_process HES7 GO:0050789 regulation_of_biological_process EMP1 GO:0050789 regulation_of_biological_process FHL2 GO:0050789 regulation_of_biological_process NFIA GO:0050789 regulation_of_biological_process IGF1 GO:0009889 regulation_of_biosynthesis PRKAA1 GO:0009889 regulation_of_biosynthesis INHA GO:0009889 regulation_of_biosynthesis RNF128 GO:0030193 regulation_of_blood_coagulation TM4SF3 GO:0008217 regulation_of_blood_pressure AGTRAP GO:0030510 regulation_of_BMP_signaling_pathway BAMBI GO:0030510 regulation_of_BMP_signaling_pathway CHRDL2 GO:0050878 regulation_of_body_fluids F2 GO:0050878 regulation_of_body_fluids PTGER3 GO:0050878 regulation_of_body_fluids FGG GO:0050878 regulation_of_body_fluids SERPINC1

131:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0050878 regulation_of_body_fluids TM4SF3 GO:0046850 regulation_of_bone_remodeling GDF10 GO:0046850 regulation_of_bone_remodeling COL1A1 GO:0006109 regulation_of_carbohydrate_metabolism PRKAA1 GO:0009894 regulation_of_catabolism ARNTL GO:0000074 regulation_of_cell_cycle ETS2 GO:0000074 regulation_of_cell_cycle SSPN GO:0000074 regulation_of_cell_cycle INHA GO:0000074 regulation_of_cell_cycle GADD45A GO:0000074 regulation_of_cell_cycle MDK GO:0000074 regulation_of_cell_cycle ID2 GO:0000074 regulation_of_cell_cycle PMP22 GO:0000074 regulation_of_cell_cycle NR2F1 GO:0000074 regulation_of_cell_cycle CDK8 GO:0000074 regulation_of_cell_cycle CDKN3 GO:0045595 regulation_of_cell_differentiation INHA GO:0001558 regulation_of_cell_growth WISP2 GO:0042127 regulation_of_cell_proliferation BAP1 GO:0042127 regulation_of_cell_proliferation WISP2 GO:0042127 regulation_of_cell_proliferation ID2 GO:0042127 regulation_of_cell_proliferation SCAP2 GO:0042127 regulation_of_cell_proliferation GAL GO:0042127 regulation_of_cell_proliferation TRAF5 GO:0008360 regulation_of_cell_shape MSN GO:0008360 regulation_of_cell_shape PPP6C GO:0008361 regulation_of_cell_size WISP2 GO:0008361 regulation_of_cell_size EMP1 GO:0050794 regulation_of_cellular_process PRKAA1 GO:0050794 regulation_of_cellular_process INHA GO:0050794 regulation_of_cellular_process BAMBI GO:0050794 regulation_of_cellular_process CHRDL2 GO:0050794 regulation_of_cellular_process GAL GO:0050794 regulation_of_cellular_process SCAP2 GO:0050794 regulation_of_cellular_process BIRC3 GO:0050794 regulation_of_cellular_process TRAF5 GO:0050794 regulation_of_cellular_process APPBP1 GO:0050794 regulation_of_cellular_process BAP1 GO:0050794 regulation_of_cellular_process WISP2 GO:0050794 regulation_of_cellular_process MSN GO:0050794 regulation_of_cellular_process SPRY1 GO:0050794 regulation_of_cellular_process PPP6C GO:0050794 regulation_of_cellular_process ID2 GO:0050794 regulation_of_cellular_process EMP1 GO:0050794 regulation_of_cellular_process CASP7 GO:0050794 regulation_of_cellular_process CADPS2 GO:0050794 regulation_of_cellular_process DKK1 GO:0050794 regulation_of_cellular_process IGF1 GO:0030300 regulation_of_cholesterol_absorption APOA2 GO:0045540 regulation_of_cholesterol_biosynthesis PRKAA1 GO:0042752 regulation_of_circadian_rhythm PTGDS GO:0042749 regulation_of_circadian_sleep/wake_cycle PTGDS GO:0045187 regulation_of_circadian_sleep/wake_cycle,_sleep PTGDS GO:0050818 regulation_of_coagulation TM4SF3 GO:0042035 regulation_of_cytokine_biosynthesis INHA GO:0042035 regulation_of_cytokine_biosynthesis RNF128 GO:0001817 regulation_of_cytokine_production INHA GO:0001817 regulation_of_cytokine_production RNF128 GO:0050793 regulation_of_development INHA GO:0050793 regulation_of_development WISP2 GO:0050793 regulation_of_development AES GO:0050793 regulation_of_development GPC3

132:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0050790 regulation_of_enzyme_activity GADD45A GO:0017157 regulation_of_exocytosis CADPS2 GO:0019217 regulation_of_fatty_acid_metabolism PRKAA1 GO:0046320 regulation_of_fatty_acid_oxidation PRKAA1 GO:0046880 regulation_of_follicle-stimulating_hormone_secretion INHA GO:0040029 regulation_of_gene_expression,_epigenetic SIRT7 GO:0040029 regulation_of_gene_expression,_epigenetic DNMT3L GO:0040029 regulation_of_gene_expression,_epigenetic DNMT3B GO:0006111 regulation_of_gluconeogenesis PRKAA1 GO:0046324 regulation_of_glucose_import PRKAA1 GO:0046317 regulation_of_glucosylceramide_biosynthesis PRKAA1 GO:0040008 regulation_of_growth WISP2 GO:0040008 regulation_of_growth AES GO:0040008 regulation_of_growth GPC3 GO:0046883 regulation_of_hormone_secretion INHA GO:0050776 regulation_of_immune_response GAL GO:0045072 regulation_of_interferon-gamma_biosynthesis INHA GO:0046890 regulation_of_lipid_biosynthesis PRKAA1 GO:0019216 regulation_of_lipid_metabolism PRKAA1 GO:0045619 regulation_of_lymphocyte_differentiation INHA GO:0050670 regulation_of_lymphocyte_proliferation GAL GO:0045649 regulation_of_macrophage_differentiation INHA GO:0019222 regulation_of_metabolism INHA GO:0019222 regulation_of_metabolism TLE4 GO:0019222 regulation_of_metabolism EPAS1 GO:0019222 regulation_of_metabolism TBX3 GO:0019222 regulation_of_metabolism SOX30 GO:0019222 regulation_of_metabolism MID1 GO:0019222 regulation_of_metabolism MTA3 GO:0019222 regulation_of_metabolism TRPS1 GO:0019222 regulation_of_metabolism SALL1 GO:0019222 regulation_of_metabolism PAX5 GO:0019222 regulation_of_metabolism POU5F1 GO:0019222 regulation_of_metabolism AHR GO:0019222 regulation_of_metabolism PPP1R12B GO:0019222 regulation_of_metabolism CEBPD GO:0019222 regulation_of_metabolism PAX3 GO:0019222 regulation_of_metabolism AES GO:0019222 regulation_of_metabolism DDX20 GO:0019222 regulation_of_metabolism TLE1 GO:0019222 regulation_of_metabolism TCF7L2 GO:0019222 regulation_of_metabolism NR2F1 GO:0019222 regulation_of_metabolism FEM1B GO:0019222 regulation_of_metabolism HEY1 GO:0019222 regulation_of_metabolism SIRT7 GO:0019222 regulation_of_metabolism TBX2 GO:0019222 regulation_of_metabolism CITED1 GO:0019222 regulation_of_metabolism SHOX2 GO:0019222 regulation_of_metabolism BHLHB3 GO:0019222 regulation_of_metabolism EMX2 GO:0019222 regulation_of_metabolism ATBF1 GO:0019222 regulation_of_metabolism BAZ1B GO:0019222 regulation_of_metabolism PRKAA1 GO:0019222 regulation_of_metabolism TCEA2 GO:0019222 regulation_of_metabolism SOX14 GO:0019222 regulation_of_metabolism KLF12 GO:0019222 regulation_of_metabolism TLX2 GO:0019222 regulation_of_metabolism MLL GO:0019222 regulation_of_metabolism APEH GO:0019222 regulation_of_metabolism ETS2 GO:0019222 regulation_of_metabolism CBFB

133:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0019222 regulation_of_metabolism HMGB2 GO:0019222 regulation_of_metabolism HESX1 GO:0019222 regulation_of_metabolism ARID3A GO:0019222 regulation_of_metabolism NSEP1 GO:0019222 regulation_of_metabolism ARNTL GO:0019222 regulation_of_metabolism HNF3B GO:0019222 regulation_of_metabolism RNF128 GO:0019222 regulation_of_metabolism AR GO:0019222 regulation_of_metabolism FOXA1 GO:0019222 regulation_of_metabolism TCF8 GO:0019222 regulation_of_metabolism ACE2 GO:0019222 regulation_of_metabolism HES7 GO:0019222 regulation_of_metabolism FHL2 GO:0019222 regulation_of_metabolism NFIA GO:0007346 regulation_of_mitotic_cell_cycle ID2 GO:0045655 regulation_of_monocyte_differentiation INHA GO:0006937 regulation_of_muscle_contraction TNNT3 GO:0045637 regulation_of_myeloid_blood_cell_differentiation INHA GO:0050767 regulation_of_neurogenesis BHLHB3 GO:0048168 regulation_of_neuronal_synaptic_plasticity BHLHB3 GO:0001505 regulation_of_neurotransmitter_levels APM2 GO:0001505 regulation_of_neurotransmitter_levels CLC GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismTLE4 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismEPAS1 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismTBX3 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismSOX30 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismMID1 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismMTA3 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismTRPS1 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismSALL1 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismPAX5 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismPOU5F1 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismAHR GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismPPP1R12B GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismPAX3 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismCEBPD GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismAES GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismDDX20 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismTCF7L2 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismTLE1 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismNR2F1 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismFEM1B GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismHEY1 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismSIRT7 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismTBX2 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismCITED1 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismSHOX2 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismBHLHB3 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismEMX2 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismATBF1 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismBAZ1B GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismTCEA2 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismSOX14 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismKLF12 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismTLX2 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismMLL GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismAPEH GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismETS2 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismCBFB GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismHMGB2 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismHESX1

134:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismARID3A GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismNSEP1 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismARNTL GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismHNF3B GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismAR GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismFOXA1 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismTCF8 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismHES7 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismACE2 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismFHL2 GO:0019219 regulation_of_nucleobase,_nucleoside,_nucleotide_and_nucleic_acid_metabolismNFIA GO:0030278 regulation_of_ossification GDF10 GO:0030278 regulation_of_ossification COL1A1 GO:0019220 regulation_of_phosphate_metabolism INHA GO:0042325 regulation_of_phosphorylation INHA GO:0050791 regulation_of_physiological_process INHA GO:0050791 regulation_of_physiological_process TLE4 GO:0050791 regulation_of_physiological_process EPAS1 GO:0050791 regulation_of_physiological_process TBX3 GO:0050791 regulation_of_physiological_process SOX30 GO:0050791 regulation_of_physiological_process MID1 GO:0050791 regulation_of_physiological_process MTA3 GO:0050791 regulation_of_physiological_process TRPS1 GO:0050791 regulation_of_physiological_process SALL1 GO:0050791 regulation_of_physiological_process PAX5 GO:0050791 regulation_of_physiological_process POU5F1 GO:0050791 regulation_of_physiological_process AHR GO:0050791 regulation_of_physiological_process PPP1R12B GO:0050791 regulation_of_physiological_process PAX3 GO:0050791 regulation_of_physiological_process CEBPD GO:0050791 regulation_of_physiological_process AES GO:0050791 regulation_of_physiological_process DDX20 GO:0050791 regulation_of_physiological_process TCF7L2 GO:0050791 regulation_of_physiological_process TLE1 GO:0050791 regulation_of_physiological_process NR2F1 GO:0050791 regulation_of_physiological_process FEM1B GO:0050791 regulation_of_physiological_process HEY1 GO:0050791 regulation_of_physiological_process SIRT7 GO:0050791 regulation_of_physiological_process TBX2 GO:0050791 regulation_of_physiological_process CITED1 GO:0050791 regulation_of_physiological_process SHOX2 GO:0050791 regulation_of_physiological_process BHLHB3 GO:0050791 regulation_of_physiological_process EMX2 GO:0050791 regulation_of_physiological_process ATBF1 GO:0050791 regulation_of_physiological_process BAZ1B GO:0050791 regulation_of_physiological_process PRKAA1 GO:0050791 regulation_of_physiological_process TCEA2 GO:0050791 regulation_of_physiological_process SOX14 GO:0050791 regulation_of_physiological_process KLF12 GO:0050791 regulation_of_physiological_process TLX2 GO:0050791 regulation_of_physiological_process MLL GO:0050791 regulation_of_physiological_process TM4SF3 GO:0050791 regulation_of_physiological_process APEH GO:0050791 regulation_of_physiological_process ETS2 GO:0050791 regulation_of_physiological_process CBFB GO:0050791 regulation_of_physiological_process HMGB2 GO:0050791 regulation_of_physiological_process HESX1 GO:0050791 regulation_of_physiological_process ARID3A GO:0050791 regulation_of_physiological_process AGTRAP GO:0050791 regulation_of_physiological_process NSEP1 GO:0050791 regulation_of_physiological_process ARNTL

135:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0050791 regulation_of_physiological_process HNF3B GO:0050791 regulation_of_physiological_process RNF128 GO:0050791 regulation_of_physiological_process AR GO:0050791 regulation_of_physiological_process FOXA1 GO:0050791 regulation_of_physiological_process TCF8 GO:0050791 regulation_of_physiological_process HES7 GO:0050791 regulation_of_physiological_process ACE2 GO:0050791 regulation_of_physiological_process FHL2 GO:0050791 regulation_of_physiological_process NFIA GO:0043067 regulation_of_programmed_cell_death PRKAA1 GO:0043067 regulation_of_programmed_cell_death INHA GO:0043067 regulation_of_programmed_cell_death BIRC3 GO:0043067 regulation_of_programmed_cell_death CASP7 GO:0043067 regulation_of_programmed_cell_death IGF1 GO:0043067 regulation_of_programmed_cell_death APPBP1 GO:0006417 regulation_of_protein_biosynthesis PRKAA1 GO:0006417 regulation_of_protein_biosynthesis INHA GO:0006417 regulation_of_protein_biosynthesis RNF128 GO:0042176 regulation_of_protein_catabolism ARNTL GO:0045859 regulation_of_protein_kinase_activity GADD45A GO:0007090 regulation_of_S_phase_of_mitotic_cell_cycle ID2 GO:0051046 regulation_of_secretion INHA GO:0009966 regulation_of_signal_transduction BAMBI GO:0009966 regulation_of_signal_transduction CHRDL2 GO:0009966 regulation_of_signal_transduction SPRY1 GO:0009966 regulation_of_signal_transduction DKK1 GO:0048167 regulation_of_synaptic_plasticity BHLHB3 GO:0045449 regulation_of_transcription TLE4 GO:0045449 regulation_of_transcription EPAS1 GO:0045449 regulation_of_transcription TBX3 GO:0045449 regulation_of_transcription SOX30 GO:0045449 regulation_of_transcription MID1 GO:0045449 regulation_of_transcription MTA3 GO:0045449 regulation_of_transcription TRPS1 GO:0045449 regulation_of_transcription PAX5 GO:0045449 regulation_of_transcription SALL1 GO:0045449 regulation_of_transcription POU5F1 GO:0045449 regulation_of_transcription AHR GO:0045449 regulation_of_transcription PPP1R12B GO:0045449 regulation_of_transcription CEBPD GO:0045449 regulation_of_transcription PAX3 GO:0045449 regulation_of_transcription AES GO:0045449 regulation_of_transcription DDX20 GO:0045449 regulation_of_transcription TCF7L2 GO:0045449 regulation_of_transcription TLE1 GO:0045449 regulation_of_transcription NR2F1 GO:0045449 regulation_of_transcription FEM1B GO:0045449 regulation_of_transcription HEY1 GO:0045449 regulation_of_transcription SIRT7 GO:0045449 regulation_of_transcription TBX2 GO:0045449 regulation_of_transcription CITED1 GO:0045449 regulation_of_transcription SHOX2 GO:0045449 regulation_of_transcription BHLHB3 GO:0045449 regulation_of_transcription EMX2 GO:0045449 regulation_of_transcription ATBF1 GO:0045449 regulation_of_transcription BAZ1B GO:0045449 regulation_of_transcription TCEA2 GO:0045449 regulation_of_transcription SOX14 GO:0045449 regulation_of_transcription KLF12 GO:0045449 regulation_of_transcription TLX2 GO:0045449 regulation_of_transcription MLL

136:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0045449 regulation_of_transcription APEH GO:0045449 regulation_of_transcription ETS2 GO:0045449 regulation_of_transcription CBFB GO:0045449 regulation_of_transcription HMGB2 GO:0045449 regulation_of_transcription HESX1 GO:0045449 regulation_of_transcription ARID3A GO:0045449 regulation_of_transcription NSEP1 GO:0045449 regulation_of_transcription ARNTL GO:0045449 regulation_of_transcription HNF3B GO:0045449 regulation_of_transcription AR GO:0045449 regulation_of_transcription FOXA1 GO:0045449 regulation_of_transcription TCF8 GO:0045449 regulation_of_transcription HES7 GO:0045449 regulation_of_transcription ACE2 GO:0045449 regulation_of_transcription FHL2 GO:0045449 regulation_of_transcription NFIA GO:0006355 regulation_of_transcription,_DNA-dependent TLE4 GO:0006355 regulation_of_transcription,_DNA-dependent EPAS1 GO:0006355 regulation_of_transcription,_DNA-dependent TBX3 GO:0006355 regulation_of_transcription,_DNA-dependent SOX30 GO:0006355 regulation_of_transcription,_DNA-dependent MID1 GO:0006355 regulation_of_transcription,_DNA-dependent MTA3 GO:0006355 regulation_of_transcription,_DNA-dependent TRPS1 GO:0006355 regulation_of_transcription,_DNA-dependent SALL1 GO:0006355 regulation_of_transcription,_DNA-dependent PAX5 GO:0006355 regulation_of_transcription,_DNA-dependent POU5F1 GO:0006355 regulation_of_transcription,_DNA-dependent AHR GO:0006355 regulation_of_transcription,_DNA-dependent PPP1R12B GO:0006355 regulation_of_transcription,_DNA-dependent PAX3 GO:0006355 regulation_of_transcription,_DNA-dependent CEBPD GO:0006355 regulation_of_transcription,_DNA-dependent AES GO:0006355 regulation_of_transcription,_DNA-dependent DDX20 GO:0006355 regulation_of_transcription,_DNA-dependent TLE1 GO:0006355 regulation_of_transcription,_DNA-dependent TCF7L2 GO:0006355 regulation_of_transcription,_DNA-dependent NR2F1 GO:0006355 regulation_of_transcription,_DNA-dependent FEM1B GO:0006355 regulation_of_transcription,_DNA-dependent HEY1 GO:0006355 regulation_of_transcription,_DNA-dependent SIRT7 GO:0006355 regulation_of_transcription,_DNA-dependent TBX2 GO:0006355 regulation_of_transcription,_DNA-dependent SHOX2 GO:0006355 regulation_of_transcription,_DNA-dependent BHLHB3 GO:0006355 regulation_of_transcription,_DNA-dependent EMX2 GO:0006355 regulation_of_transcription,_DNA-dependent ATBF1 GO:0006355 regulation_of_transcription,_DNA-dependent BAZ1B GO:0006355 regulation_of_transcription,_DNA-dependent TCEA2 GO:0006355 regulation_of_transcription,_DNA-dependent SOX14 GO:0006355 regulation_of_transcription,_DNA-dependent KLF12 GO:0006355 regulation_of_transcription,_DNA-dependent TLX2 GO:0006355 regulation_of_transcription,_DNA-dependent MLL GO:0006355 regulation_of_transcription,_DNA-dependent APEH GO:0006355 regulation_of_transcription,_DNA-dependent ETS2 GO:0006355 regulation_of_transcription,_DNA-dependent CBFB GO:0006355 regulation_of_transcription,_DNA-dependent HMGB2 GO:0006355 regulation_of_transcription,_DNA-dependent HESX1 GO:0006355 regulation_of_transcription,_DNA-dependent ARID3A GO:0006355 regulation_of_transcription,_DNA-dependent NSEP1 GO:0006355 regulation_of_transcription,_DNA-dependent ARNTL GO:0006355 regulation_of_transcription,_DNA-dependent HNF3B GO:0006355 regulation_of_transcription,_DNA-dependent AR GO:0006355 regulation_of_transcription,_DNA-dependent FOXA1 GO:0006355 regulation_of_transcription,_DNA-dependent TCF8

137:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006355 regulation_of_transcription,_DNA-dependent HES7 GO:0006355 regulation_of_transcription,_DNA-dependent ACE2 GO:0006355 regulation_of_transcription,_DNA-dependent FHL2 GO:0006355 regulation_of_transcription,_DNA-dependent NFIA GO:0006357 regulation_of_transcription_from_Pol_II_promoter CBFB GO:0006357 regulation_of_transcription_from_Pol_II_promoter TBX2 GO:0006357 regulation_of_transcription_from_Pol_II_promoter SOX14 GO:0006357 regulation_of_transcription_from_Pol_II_promoter BHLHB3 GO:0006357 regulation_of_transcription_from_Pol_II_promoter DDX20 GO:0006357 regulation_of_transcription_from_Pol_II_promoter HES7 GO:0006357 regulation_of_transcription_from_Pol_II_promoter ACE2 GO:0006357 regulation_of_transcription_from_Pol_II_promoter TLE1 GO:0006357 regulation_of_transcription_from_Pol_II_promoter FHL2 GO:0017015 regulation_of_transforming_growth_factor_beta_receptor_signaling_pathway BAMBI GO:0017015 regulation_of_transforming_growth_factor_beta_receptor_signaling_pathway CHRDL2 GO:0051049 regulation_of_transport PRKAA1 GO:0051049 regulation_of_transport CADPS2 GO:0030111 regulation_of_Wnt_receptor_signaling_pathway DKK1 GO:0000003 reproduction AFP GO:0000003 reproduction DNMT3L GO:0000003 reproduction MSN GO:0000003 reproduction PAX5 GO:0000003 reproduction TBPL1 GO:0000003 reproduction PRM2 GO:0050876 reproductive_physiological_process AFP GO:0050876 reproductive_physiological_process INHA GO:0045277 respiratory_chain_complex_IV COX6A2 GO:0045277 respiratory_chain_complex_IV COX7C GO:0005751 respiratory_chain_complex_IV_(sensu_Eukarya) COX6A2 GO:0005751 respiratory_chain_complex_IV_(sensu_Eukarya) COX7C GO:0009628 response_to_abiotic_stimulus AHR GO:0009628 response_to_abiotic_stimulus GSTP1 GO:0009628 response_to_abiotic_stimulus GLB1 GO:0009628 response_to_abiotic_stimulus PDCL3 GO:0009628 response_to_abiotic_stimulus GSTA1 GO:0009628 response_to_abiotic_stimulus MT1A GO:0009628 response_to_abiotic_stimulus CRYAB GO:0009628 response_to_abiotic_stimulus GMPR GO:0009628 response_to_abiotic_stimulus NDUFB9 GO:0009628 response_to_abiotic_stimulus BAP1 GO:0009628 response_to_abiotic_stimulus HSPA1A GO:0009628 response_to_abiotic_stimulus CX3CL1 GO:0009628 response_to_abiotic_stimulus CIRBP GO:0009607 response_to_biotic_stimulus INHA GO:0009607 response_to_biotic_stimulus TCEA2 GO:0009607 response_to_biotic_stimulus RNF128 GO:0009607 response_to_biotic_stimulus PTGER3 GO:0009607 response_to_biotic_stimulus C6 GO:0009607 response_to_biotic_stimulus TNFRSF1A GO:0009607 response_to_biotic_stimulus GAL GO:0009607 response_to_biotic_stimulus INDO GO:0009607 response_to_biotic_stimulus GGTLA1 GO:0009607 response_to_biotic_stimulus F2 GO:0009607 response_to_biotic_stimulus TAPBP GO:0009607 response_to_biotic_stimulus CBFB GO:0009607 response_to_biotic_stimulus FN1 GO:0009607 response_to_biotic_stimulus IL27RA GO:0009607 response_to_biotic_stimulus LY6E GO:0009607 response_to_biotic_stimulus HSPA1A GO:0009607 response_to_biotic_stimulus PRNP GO:0009607 response_to_biotic_stimulus TLR8

138:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0009607 response_to_biotic_stimulus ENPEP GO:0009607 response_to_biotic_stimulus CX3CL1 GO:0009607 response_to_biotic_stimulus FGG GO:0009607 response_to_biotic_stimulus LST1 GO:0009607 response_to_biotic_stimulus PAP GO:0009743 response_to_carbohydrate_stimulus GLB1 GO:0042221 response_to_chemical_substance AHR GO:0042221 response_to_chemical_substance GSTP1 GO:0042221 response_to_chemical_substance GSTA1 GO:0042221 response_to_chemical_substance CX3CL1 GO:0042221 response_to_chemical_substance MT1A GO:0050895 response_to_circadian_rhythm PTGDS GO:0009409 response_to_cold CIRBP GO:0009409 response_to_cold GMPR GO:0046688 response_to_copper_ion MT1A GO:0006974 response_to_DNA_damage_stimulus ASF1A GO:0006974 response_to_DNA_damage_stimulus TERF1 GO:0006974 response_to_DNA_damage_stimulus HSPA1A GO:0006974 response_to_DNA_damage_stimulus GADD45A GO:0006974 response_to_DNA_damage_stimulus FEN1 GO:0006974 response_to_DNA_damage_stimulus MLL GO:0042493 response_to_drug GSTA1 GO:0009719 response_to_endogenous_stimulus TERF1 GO:0009719 response_to_endogenous_stimulus ASF1A GO:0009719 response_to_endogenous_stimulus GLB1 GO:0009719 response_to_endogenous_stimulus HSPA1A GO:0009719 response_to_endogenous_stimulus FEN1 GO:0009719 response_to_endogenous_stimulus GADD45A GO:0009719 response_to_endogenous_stimulus MLL GO:0009605 response_to_external_stimulus GSTP1 GO:0009605 response_to_external_stimulus INHA GO:0009605 response_to_external_stimulus TCEA2 GO:0009605 response_to_external_stimulus PTGER3 GO:0009605 response_to_external_stimulus GSTA1 GO:0009605 response_to_external_stimulus GAL GO:0009605 response_to_external_stimulus GMPR GO:0009605 response_to_external_stimulus INDO GO:0009605 response_to_external_stimulus FABP5 GO:0009605 response_to_external_stimulus GGTLA1 GO:0009605 response_to_external_stimulus CBFB GO:0009605 response_to_external_stimulus TAPBP GO:0009605 response_to_external_stimulus LY6E GO:0009605 response_to_external_stimulus IL27RA GO:0009605 response_to_external_stimulus ENPEP GO:0009605 response_to_external_stimulus TLR8 GO:0009605 response_to_external_stimulus FGG GO:0009605 response_to_external_stimulus PAP GO:0009605 response_to_external_stimulus LST1 GO:0009605 response_to_external_stimulus AHR GO:0009605 response_to_external_stimulus GLB1 GO:0009605 response_to_external_stimulus PDCL3 GO:0009605 response_to_external_stimulus RNF128 GO:0009605 response_to_external_stimulus C6 GO:0009605 response_to_external_stimulus MT1A GO:0009605 response_to_external_stimulus TNFRSF1A GO:0009605 response_to_external_stimulus NR2F1 GO:0009605 response_to_external_stimulus CRYAB GO:0009605 response_to_external_stimulus F2 GO:0009605 response_to_external_stimulus NDUFB9 GO:0009605 response_to_external_stimulus FN1 GO:0009605 response_to_external_stimulus BAP1

139:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0009605 response_to_external_stimulus PRNP GO:0009605 response_to_external_stimulus HSPA1A GO:0009605 response_to_external_stimulus CX3CL1 GO:0009605 response_to_external_stimulus CIRBP GO:0009408 response_to_heat HSPA1A GO:0009408 response_to_heat CRYAB GO:0009644 response_to_high_light_intensity MT1A GO:0001666 response_to_hypoxia PRKAA1 GO:0001666 response_to_hypoxia EPAS1 GO:0001666 response_to_hypoxia ATP1B1 GO:0010035 response_to_inorganic_substance MT1A GO:0009416 response_to_light GLB1 GO:0009416 response_to_light PDCL3 GO:0009416 response_to_light MT1A GO:0009642 response_to_light_intensity MT1A GO:0010038 response_to_metal_ion MT1A GO:0006979 response_to_oxidative_stress GGTLA1 GO:0006979 response_to_oxidative_stress PRNP GO:0009613 response_to_pest/pathogen/parasite GGTLA1 GO:0009613 response_to_pest/pathogen/parasite F2 GO:0009613 response_to_pest/pathogen/parasite INHA GO:0009613 response_to_pest/pathogen/parasite FN1 GO:0009613 response_to_pest/pathogen/parasite PTGER3 GO:0009613 response_to_pest/pathogen/parasite TLR8 GO:0009613 response_to_pest/pathogen/parasite FGG GO:0009613 response_to_pest/pathogen/parasite C6 GO:0009613 response_to_pest/pathogen/parasite TNFRSF1A GO:0009613 response_to_pest/pathogen/parasite PAP GO:0009314 response_to_radiation GLB1 GO:0009314 response_to_radiation PDCL3 GO:0009314 response_to_radiation MT1A GO:0050896 response_to_stimulus PRKAA1 GO:0050896 response_to_stimulus INHA GO:0050896 response_to_stimulus GSTP1 GO:0050896 response_to_stimulus TCEA2 GO:0050896 response_to_stimulus EPAS1 GO:0050896 response_to_stimulus GADD45A GO:0050896 response_to_stimulus PTGER3 GO:0050896 response_to_stimulus GSTA1 GO:0050896 response_to_stimulus ATP1B1 GO:0050896 response_to_stimulus GAL GO:0050896 response_to_stimulus CRH GO:0050896 response_to_stimulus MLL GO:0050896 response_to_stimulus GMPR GO:0050896 response_to_stimulus INDO GO:0050896 response_to_stimulus FABP5 GO:0050896 response_to_stimulus GGTLA1 GO:0050896 response_to_stimulus CBFB GO:0050896 response_to_stimulus TAPBP GO:0050896 response_to_stimulus LY6E GO:0050896 response_to_stimulus IL27RA GO:0050896 response_to_stimulus ENPEP GO:0050896 response_to_stimulus TLR8 GO:0050896 response_to_stimulus FGG GO:0050896 response_to_stimulus LST1 GO:0050896 response_to_stimulus PAP GO:0050896 response_to_stimulus ASF1A GO:0050896 response_to_stimulus TERF1 GO:0050896 response_to_stimulus AHR GO:0050896 response_to_stimulus GLB1 GO:0050896 response_to_stimulus PDCL3

140:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0050896 response_to_stimulus RNF128 GO:0050896 response_to_stimulus C6 GO:0050896 response_to_stimulus TNFRSF1A GO:0050896 response_to_stimulus MT1A GO:0050896 response_to_stimulus NR2F1 GO:0050896 response_to_stimulus CRYAB GO:0050896 response_to_stimulus PTGDS GO:0050896 response_to_stimulus F2 GO:0050896 response_to_stimulus NDUFB9 GO:0050896 response_to_stimulus BAP1 GO:0050896 response_to_stimulus FN1 GO:0050896 response_to_stimulus PRNP GO:0050896 response_to_stimulus HSPA1A GO:0050896 response_to_stimulus FEN1 GO:0050896 response_to_stimulus CX3CL1 GO:0050896 response_to_stimulus CIRBP GO:0006950 response_to_stress PRKAA1 GO:0006950 response_to_stress INHA GO:0006950 response_to_stress EPAS1 GO:0006950 response_to_stress GADD45A GO:0006950 response_to_stress PTGER3 GO:0006950 response_to_stress ATP1B1 GO:0006950 response_to_stress MLL GO:0006950 response_to_stress CRH GO:0006950 response_to_stress GMPR GO:0006950 response_to_stress GGTLA1 GO:0006950 response_to_stress FABP5 GO:0006950 response_to_stress TLR8 GO:0006950 response_to_stress FGG GO:0006950 response_to_stress PAP GO:0006950 response_to_stress TERF1 GO:0006950 response_to_stress ASF1A GO:0006950 response_to_stress AHR GO:0006950 response_to_stress C6 GO:0006950 response_to_stress TNFRSF1A GO:0006950 response_to_stress CRYAB GO:0006950 response_to_stress F2 GO:0006950 response_to_stress FN1 GO:0006950 response_to_stress HSPA1A GO:0006950 response_to_stress PRNP GO:0006950 response_to_stress FEN1 GO:0006950 response_to_stress CIRBP GO:0009744 response_to_sucrose_stimulus GLB1 GO:0009266 response_to_temperature BAP1 GO:0009266 response_to_temperature HSPA1A GO:0009266 response_to_temperature CIRBP GO:0009266 response_to_temperature CRYAB GO:0009266 response_to_temperature GMPR GO:0009611 response_to_wounding FABP5 GO:0009611 response_to_wounding F2 GO:0009611 response_to_wounding GGTLA1 GO:0009611 response_to_wounding INHA GO:0009611 response_to_wounding FN1 GO:0009611 response_to_wounding PTGER3 GO:0009611 response_to_wounding TLR8 GO:0009611 response_to_wounding FGG GO:0009611 response_to_wounding TNFRSF1A GO:0009611 response_to_wounding PAP GO:0009410 response_to_xenobiotic_stimulus AHR GO:0009410 response_to_xenobiotic_stimulus GSTP1 GO:0005501 retinoid_binding TTR

141:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005501 retinoid_binding PTGDS GO:0019841 retinol_binding TTR GO:0007266 Rho_protein_signal_transduction CDC42EP4 GO:0001584 rhodopsin-like_receptor_activity SLC19A2 GO:0001584 rhodopsin-like_receptor_activity GPR45 GO:0001584 rhodopsin-like_receptor_activity PTGER3 GO:0001584 rhodopsin-like_receptor_activity ADORA2B GO:0001584 rhodopsin-like_receptor_activity BRS3 GO:0001584 rhodopsin-like_receptor_activity GPR6 GO:0001584 rhodopsin-like_receptor_activity CCKBR GO:0001584 rhodopsin-like_receptor_activity AGTRAP GO:0007622 rhythmic_behavior ARNTL GO:0007622 rhythmic_behavior BHLHB3 GO:0007622 rhythmic_behavior PTGDS GO:0030529 ribonucleoprotein_complex RPL29 GO:0030529 ribonucleoprotein_complex RPL18A GO:0030529 ribonucleoprotein_complex RPS8 GO:0030529 ribonucleoprotein_complex GADD45A GO:0030529 ribonucleoprotein_complex RPL28 GO:0030529 ribonucleoprotein_complex DDX20 GO:0009156 ribonucleoside_monophosphate_biosynthesis PAICS GO:0009156 ribonucleoside_monophosphate_biosynthesis AMPD2 GO:0009158 ribonucleoside_monophosphate_catabolism GMPR2 GO:0009161 ribonucleoside_monophosphate_metabolism PAICS GO:0009161 ribonucleoside_monophosphate_metabolism AMPD2 GO:0009161 ribonucleoside_monophosphate_metabolism GMPR2 GO:0009201 ribonucleoside_triphosphate_biosynthesis ATP6V1E2 GO:0009199 ribonucleoside_triphosphate_metabolism ATP6V1E2 GO:0009260 ribonucleotide_biosynthesis PAICS GO:0009260 ribonucleotide_biosynthesis AMPD2 GO:0009260 ribonucleotide_biosynthesis ATP6V1E2 GO:0009261 ribonucleotide_catabolism GMPR2 GO:0009259 ribonucleotide_metabolism PAICS GO:0009259 ribonucleotide_metabolism AMPD2 GO:0009259 ribonucleotide_metabolism GMPR2 GO:0009259 ribonucleotide_metabolism ATP6V1E2 GO:0005840 ribosome RPL29 GO:0005840 ribosome RPL18A GO:0005840 ribosome RPS8 GO:0005840 ribosome GADD45A GO:0005840 ribosome RPL28 GO:0007046 ribosome_biogenesis RPL29 GO:0007046 ribosome_biogenesis RPS8 GO:0007046 ribosome_biogenesis RPL28 GO:0007046 ribosome_biogenesis PRH1 GO:0042254 ribosome_biogenesis_and_assembly RPL29 GO:0042254 ribosome_biogenesis_and_assembly RPS8 GO:0042254 ribosome_biogenesis_and_assembly RPL28 GO:0042254 ribosome_biogenesis_and_assembly PRH1 GO:0003723 RNA_binding DDX25 GO:0003723 RNA_binding RBPMS GO:0003723 RNA_binding YBX2 GO:0003723 RNA_binding HDLBP GO:0003723 RNA_binding TENR GO:0003723 RNA_binding RPS8 GO:0003723 RNA_binding RPL28 GO:0003723 RNA_binding HNRPM GO:0003723 RNA_binding CIRBP GO:0006354 RNA_elongation TCEA2 GO:0003724 RNA_helicase_activity DDX25 GO:0008452 RNA_ligase_activity NARS

142:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008452 RNA_ligase_activity WARS GO:0008452 RNA_ligase_activity CDH16 GO:0016070 RNA_metabolism NARS GO:0016070 RNA_metabolism TENR GO:0016070 RNA_metabolism WARS GO:0016070 RNA_metabolism CDH16 GO:0016070 RNA_metabolism DDX20 GO:0009451 RNA_modification NARS GO:0009451 RNA_modification WARS GO:0009451 RNA_modification CDH16 GO:0003702 RNA_polymerase_II_transcription_factor_activity CDK8 GO:0016455 RNA_polymerase_II_transcription_mediator_activity CDK8 GO:0006396 RNA_processing TENR GO:0006396 RNA_processing DDX20 GO:0005791 rough_endoplasmic_reticulum PTGDS GO:0008757 S-adenosylmethionine-dependent_methyltransferase_activity WBSCR22 GO:0030017 sarcomere MYH11 GO:0030017 sarcomere CKMT2 GO:0030017 sarcomere TNNT3 GO:0005124 scavenger_receptor_binding PDZK1 GO:0019005 SCF_ubiquitin_ligase_complex CUL1 GO:0019748 secondary_metabolism GLB1 GO:0019932 second-messenger-mediated_signaling PTGER3 GO:0019932 second-messenger-mediated_signaling DSCR1L2 GO:0046903 secretion INHA GO:0046903 secretion APM2 GO:0046903 secretion CLC GO:0045045 secretory_pathway ANXA4 GO:0045045 secretory_pathway FOLR1 GO:0045045 secretory_pathway CADPS2 GO:0007423 sensory_organ_development CRYAB GO:0007600 sensory_perception NDUFB9 GO:0007600 sensory_perception NR2F1 GO:0050953 sensory_perception_of_light NR2F1 GO:0050954 sensory_perception_of_mechanical_stimulus NDUFB9 GO:0009070 serine_family_amino_acid_biosynthesis CBS GO:0009069 serine_family_amino_acid_metabolism CBS GO:0004252 serine-type_endopeptidase_activity F2 GO:0004252 serine-type_endopeptidase_activity COL6A1 GO:0004252 serine-type_endopeptidase_activity PLAT GO:0004252 serine-type_endopeptidase_activity C1R GO:0004252 serine-type_endopeptidase_activity FAP GO:0004252 serine-type_endopeptidase_activity APEH GO:0004867 serine-type_endopeptidase_inhibitor_activity AMBP GO:0004867 serine-type_endopeptidase_inhibitor_activity SERPINC1 GO:0004867 serine-type_endopeptidase_inhibitor_activity PAPLN GO:0008236 serine-type_peptidase_activity F2 GO:0008236 serine-type_peptidase_activity COL6A1 GO:0008236 serine-type_peptidase_activity PLAT GO:0008236 serine-type_peptidase_activity C1R GO:0008236 serine-type_peptidase_activity FAP GO:0008236 serine-type_peptidase_activity APEH GO:0007530 sex_determination SOX14 GO:0019953 sexual_reproduction AFP GO:0019953 sexual_reproduction DNMT3L GO:0019953 sexual_reproduction MSN GO:0019953 sexual_reproduction PAX5 GO:0019953 sexual_reproduction TBPL1 GO:0019953 sexual_reproduction PRM2 GO:0005070 SH3/SH2_adaptor_protein_activity GRB14 GO:0030935 sheet-forming_collagen COL4A6

143:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0030935 sheet-forming_collagen COL4A5 GO:0008373 sialyltransferase_activity SIAT4C GO:0004871 signal_transducer_activity GPC4 GO:0004871 signal_transducer_activity INHA GO:0004871 signal_transducer_activity EPAS1 GO:0004871 signal_transducer_activity DSCAM GO:0004871 signal_transducer_activity PTGER3 GO:0004871 signal_transducer_activity HNRPM GO:0004871 signal_transducer_activity HDGF GO:0004871 signal_transducer_activity GAL GO:0004871 signal_transducer_activity CRH GO:0004871 signal_transducer_activity FOLR1 GO:0004871 signal_transducer_activity IL27RA GO:0004871 signal_transducer_activity TLR8 GO:0004871 signal_transducer_activity PDZK1 GO:0004871 signal_transducer_activity CDK8 GO:0004871 signal_transducer_activity NRBP GO:0004871 signal_transducer_activity FZD7 GO:0004871 signal_transducer_activity AHR GO:0004871 signal_transducer_activity PTPRD GO:0004871 signal_transducer_activity GRIN2D GO:0004871 signal_transducer_activity PTPRK GO:0004871 signal_transducer_activity ANGPTL1 GO:0004871 signal_transducer_activity IFNGR2 GO:0004871 signal_transducer_activity FZD4 GO:0004871 signal_transducer_activity SEMA5B GO:0004871 signal_transducer_activity PTPN13 GO:0004871 signal_transducer_activity NR2F1 GO:0004871 signal_transducer_activity PTPRR GO:0004871 signal_transducer_activity FEM1B GO:0004871 signal_transducer_activity VLDLR GO:0004871 signal_transducer_activity SLC19A2 GO:0004871 signal_transducer_activity GRB14 GO:0004871 signal_transducer_activity CART GO:0004871 signal_transducer_activity CX3CL1 GO:0004871 signal_transducer_activity SEMA4C GO:0004871 signal_transducer_activity S100A11 GO:0004871 signal_transducer_activity MAPK4 GO:0004871 signal_transducer_activity IL22RA1 GO:0004871 signal_transducer_activity GDF10 GO:0004871 signal_transducer_activity EPHA3 GO:0004871 signal_transducer_activity CLEC2 GO:0004871 signal_transducer_activity AGTRAP GO:0004871 signal_transducer_activity GNA11 GO:0004871 signal_transducer_activity BMP2 GO:0004871 signal_transducer_activity MS4A2 GO:0004871 signal_transducer_activity ARNTL GO:0004871 signal_transducer_activity GNAI1 GO:0004871 signal_transducer_activity AR GO:0004871 signal_transducer_activity BRS3 GO:0004871 signal_transducer_activity TNFRSF1A GO:0004871 signal_transducer_activity OGN GO:0004871 signal_transducer_activity PRKAR2A GO:0004871 signal_transducer_activity GDF3 GO:0004871 signal_transducer_activity TRAF5 GO:0004871 signal_transducer_activity INSL3 GO:0004871 signal_transducer_activity GPR6 GO:0004871 signal_transducer_activity GPR45 GO:0004871 signal_transducer_activity MSN GO:0004871 signal_transducer_activity ADORA2B GO:0004871 signal_transducer_activity SORL1

144:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0004871 signal_transducer_activity CGA GO:0004871 signal_transducer_activity LRP10 GO:0004871 signal_transducer_activity MDK GO:0004871 signal_transducer_activity SCARB1 GO:0004871 signal_transducer_activity ROR1 GO:0004871 signal_transducer_activity CCKBR GO:0004871 signal_transducer_activity IGF1 GO:0007165 signal_transduction PRKAR2B GO:0007165 signal_transduction INHA GO:0007165 signal_transduction TLE4 GO:0007165 signal_transduction EPAS1 GO:0007165 signal_transduction PTGER3 GO:0007165 signal_transduction GAL GO:0007165 signal_transduction RRAS2 GO:0007165 signal_transduction OCA2 GO:0007165 signal_transduction SPA17 GO:0007165 signal_transduction LRRN3 GO:0007165 signal_transduction PDZK1 GO:0007165 signal_transduction NRBP GO:0007165 signal_transduction FZD7 GO:0007165 signal_transduction AHR GO:0007165 signal_transduction PTPRD GO:0007165 signal_transduction BAMBI GO:0007165 signal_transduction PTPRK GO:0007165 signal_transduction ANGPTL1 GO:0007165 signal_transduction FZD4 GO:0007165 signal_transduction TCF7L2 GO:0007165 signal_transduction TLE1 GO:0007165 signal_transduction MT1A GO:0007165 signal_transduction PTPN13 GO:0007165 signal_transduction GNB2L1 GO:0007165 signal_transduction PTPRR GO:0007165 signal_transduction SLC19A2 GO:0007165 signal_transduction ITGBL1 GO:0007165 signal_transduction GRB14 GO:0007165 signal_transduction CART GO:0007165 signal_transduction CX3CL1 GO:0007165 signal_transduction DKK1 GO:0007165 signal_transduction CXXC4 GO:0007165 signal_transduction PRKAA1 GO:0007165 signal_transduction CHRDL2 GO:0007165 signal_transduction ARL4 GO:0007165 signal_transduction CDC42EP4 GO:0007165 signal_transduction CLEC2 GO:0007165 signal_transduction EPHA3 GO:0007165 signal_transduction GNA11 GO:0007165 signal_transduction BMP2 GO:0007165 signal_transduction SLC2A1 GO:0007165 signal_transduction MS4A2 GO:0007165 signal_transduction RACGAP1 GO:0007165 signal_transduction ARNTL GO:0007165 signal_transduction GNAI1 GO:0007165 signal_transduction BRS3 GO:0007165 signal_transduction TNFRSF1A GO:0007165 signal_transduction PRKAR2A GO:0007165 signal_transduction DSCR1L2 GO:0007165 signal_transduction TRAF5 GO:0007165 signal_transduction GPR6 GO:0007165 signal_transduction STMN1 GO:0007165 signal_transduction GPR45 GO:0007165 signal_transduction MSN

145:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0007165 signal_transduction ADORA2B GO:0007165 signal_transduction SPRY1 GO:0007165 signal_transduction HES7 GO:0007165 signal_transduction IGF1 GO:0007165 signal_transduction CCKBR GO:0003697 single-stranded_DNA_binding SSBP1 GO:0030427 site_of_polarized_growth DCTN2 GO:0001501 skeletal_development GNA11 GO:0001501 skeletal_development CBFB GO:0001501 skeletal_development AES GO:0001501 skeletal_development GDF10 GO:0001501 skeletal_development COL1A1 GO:0001501 skeletal_development TNA GO:0030431 sleep PTGDS GO:0007264 small_GTPase_mediated_signal_transduction CDC42EP4 GO:0007264 small_GTPase_mediated_signal_transduction ARL4 GO:0007264 small_GTPase_mediated_signal_transduction RRAS2 GO:0005083 small_GTPase_regulatory/interacting_protein_activity MCF2 GO:0003925 small_monomeric_GTPase_activity ARL4 GO:0008641 small_protein_activating_enzyme_activity UBA2 GO:0015935 small_ribosomal_subunit RPL18A GO:0015935 small_ribosomal_subunit RPS8 GO:0006939 smooth_muscle_contraction MYH11 GO:0019950 SMT3-dependent_protein_catabolism UBA2 GO:0004679 SNF1A/AMP-activated_protein_kinase_activity PRKAA1 GO:0005391 sodium/potassium-exchanging_ATPase_activity ATP1B1 GO:0005890 sodium/potassium-exchanging_ATPase_complex ATP1B1 GO:0005272 sodium_channel_activity SCN9A GO:0006814 sodium_ion_transport SLC17A1 GO:0006814 sodium_ion_transport SCN9A GO:0006814 sodium_ion_transport ATP1B1 GO:0015081 sodium_ion_transporter_activity NDUFB9 GO:0005625 soluble_fraction NARS GO:0001756 somitogenesis EPHA3 GO:0007286 spermatid_development TBPL1 GO:0007286 spermatid_development PRM2 GO:0007283 spermatogenesis DNMT3L GO:0007283 spermatogenesis PAX5 GO:0007283 spermatogenesis TBPL1 GO:0007283 spermatogenesis PRM2 GO:0046520 sphingoid_biosynthesis PRKAA1 GO:0046521 sphingoid_catabolism GALC GO:0046519 sphingoid_metabolism GALC GO:0046519 sphingoid_metabolism PRKAA1 GO:0030148 sphingolipid_biosynthesis PRKAA1 GO:0030148 sphingolipid_biosynthesis FEN1 GO:0030149 sphingolipid_catabolism GALC GO:0006665 sphingolipid_metabolism GALC GO:0006665 sphingolipid_metabolism PRKAA1 GO:0006665 sphingolipid_metabolism FEN1 GO:0005819 spindle SPAG5 GO:0005819 spindle CETN3 GO:0005819 spindle H2AFY GO:0007051 spindle_assembly STMN1 GO:0005876 spindle_microtubule SPAG5 GO:0000922 spindle_pole CETN3 GO:0000922 spindle_pole H2AFY GO:0005681 spliceosome_complex DDX20 GO:0017145 stem_cell_renewal NANOG GO:0004508 steroid_17-alpha-monooxygenase_activity CYP17A1 GO:0005496 steroid_binding TTR

146:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005496 steroid_binding STAR GO:0005496 steroid_binding AR GO:0005496 steroid_binding SULT1E1 GO:0006694 steroid_biosynthesis CYP17A1 GO:0006694 steroid_biosynthesis IDI1 GO:0006694 steroid_biosynthesis PRKAA1 GO:0006694 steroid_biosynthesis HSD17B1 GO:0006694 steroid_biosynthesis HSD3B2 GO:0006694 steroid_biosynthesis STAR GO:0006694 steroid_biosynthesis HSD3B1 GO:0016229 steroid_dehydrogenase_activity HSD17B1 GO:0016229 steroid_dehydrogenase_activity HSD3B2 GO:0016229 steroid_dehydrogenase_activity HSD3B1 GO:0004769 steroid_delta-isomerase_activity HSD3B2 GO:0004769 steroid_delta-isomerase_activity HSD3B1 GO:0003707 steroid_hormone_receptor_activity AR GO:0003707 steroid_hormone_receptor_activity NR2F1 GO:0008395 steroid_hydroxylase_activity CYP17A1 GO:0008202 steroid_metabolism AFP GO:0008202 steroid_metabolism CYP17A1 GO:0008202 steroid_metabolism PRKAA1 GO:0008202 steroid_metabolism IDI1 GO:0008202 steroid_metabolism HSD17B1 GO:0008202 steroid_metabolism HDLBP GO:0008202 steroid_metabolism HSD3B2 GO:0008202 steroid_metabolism STAR GO:0008202 steroid_metabolism SORL1 GO:0008202 steroid_metabolism APOB GO:0008202 steroid_metabolism HSD3B1 GO:0008202 steroid_metabolism VLDLR GO:0016126 sterol_biosynthesis PRKAA1 GO:0016126 sterol_biosynthesis IDI1 GO:0016125 sterol_metabolism IDI1 GO:0016125 sterol_metabolism PRKAA1 GO:0016125 sterol_metabolism HDLBP GO:0016125 sterol_metabolism SORL1 GO:0016125 sterol_metabolism APOB GO:0016125 sterol_metabolism VLDLR GO:0015918 sterol_transport PDZK1 GO:0015918 sterol_transport APOB GO:0015248 sterol_transporter_activity STAR GO:0000322 storage_vacuole CPR8 GO:0043149 stress_fiber_formation ELN GO:0006941 striated_muscle_contraction MYH11 GO:0005863 striated_muscle_thick_filament MYH11 GO:0005865 striated_muscle_thin_filament TNNT3 GO:0030527 structural_constituent_of_chromatin HMGB2 GO:0005200 structural_constituent_of_cytoskeleton TNNT3 GO:0005212 structural_constituent_of_eye_lens CRYAB GO:0003735 structural_constituent_of_ribosome RPL29 GO:0003735 structural_constituent_of_ribosome RPL18A GO:0003735 structural_constituent_of_ribosome RPS8 GO:0003735 structural_constituent_of_ribosome GADD45A GO:0003735 structural_constituent_of_ribosome RPL28 GO:0005198 structural_molecule_activity COL6A2 GO:0005198 structural_molecule_activity RPL18A GO:0005198 structural_molecule_activity COPE GO:0005198 structural_molecule_activity GADD45A GO:0005198 structural_molecule_activity RPL28 GO:0005198 structural_molecule_activity THBS2 GO:0005198 structural_molecule_activity TNNT3

147:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005198 structural_molecule_activity COL5A2 GO:0005198 structural_molecule_activity COL6A1 GO:0005198 structural_molecule_activity HMGB2 GO:0005198 structural_molecule_activity RPS8 GO:0005198 structural_molecule_activity MPZ GO:0005198 structural_molecule_activity EPPK1 GO:0005198 structural_molecule_activity RPL29 GO:0005198 structural_molecule_activity COL4A6 GO:0005198 structural_molecule_activity COL1A2 GO:0005198 structural_molecule_activity PTPN13 GO:0005198 structural_molecule_activity ELN GO:0005198 structural_molecule_activity CRYAB GO:0005198 structural_molecule_activity COL16A1 GO:0005198 structural_molecule_activity LAMB2 GO:0005198 structural_molecule_activity MSN GO:0005198 structural_molecule_activity COL14A1 GO:0005198 structural_molecule_activity COL1A1 GO:0005198 structural_molecule_activity COL4A5 GO:0004289 subtilase_activity COL6A1 GO:0004774 succinate-CoA_ligase_activity SUCLA2 GO:0005529 sugar_binding LGALS8 GO:0005529 sugar_binding CLEC2 GO:0005529 sugar_binding GFPT2 GO:0005529 sugar_binding TNA GO:0005529 sugar_binding PAP GO:0005351 sugar_porter_activity SLC2A1 GO:0005351 sugar_porter_activity SLC2A3 GO:0005351 sugar_porter_activity TBPL1 GO:0008146 sulfotransferase_activity TPST2 GO:0008146 sulfotransferase_activity HS2ST1 GO:0008146 sulfotransferase_activity SULT1E1 GO:0000097 sulfur_amino_acid_biosynthesis CBS GO:0000096 sulfur_amino_acid_metabolism CBS GO:0006790 sulfur_metabolism GGTLA1 GO:0006790 sulfur_metabolism GSTA1 GO:0006790 sulfur_metabolism HS2ST1 GO:0006790 sulfur_metabolism MGST1 GO:0006790 sulfur_metabolism CBS GO:0019948 SUMO_activating_enzyme_activity UBA2 GO:0015293 symporter_activity SLC17A1 GO:0045202 synapse CADPS2 GO:0050808 synapse_organization_and_biogenesis BHLHB3 GO:0007129 synapsis SYCP2 GO:0007268 synaptic_transmission GRIN2D GO:0007268 synaptic_transmission CART GO:0007268 synaptic_transmission APM2 GO:0007268 synaptic_transmission CLC GO:0008021 synaptic_vesicle CLC GO:0008021 synaptic_vesicle CADPS2 GO:0016183 synaptic_vesicle_coating CLC GO:0008099 synaptic_vesicle_endocytosis CLC GO:0016181 synaptic_vesicle_transport CLC GO:0007416 synaptogenesis BHLHB3 GO:0000795 synaptonemal_complex SYCP2 GO:0007130 synaptonemal_complex_formation SYCP2 GO:0017025 TATA-binding_protein_binding TIP120B GO:0042330 taxis CX3CL1 GO:0007004 telomerase-dependent_telomere_maintenance TERF1 GO:0000723 telomere_maintenance TERF1 GO:0000723 telomere_maintenance HSPA1A GO:0046246 terpene_biosynthesis IDI1

148:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0042214 terpene_metabolism IDI1 GO:0016114 terpenoid_biosynthesis IDI1 GO:0006721 terpenoid_metabolism IDI1 GO:0006729 tetrahydrobiopterin_biosynthesis PCBD GO:0046146 tetrahydrobiopterin_metabolism PCBD GO:0046906 tetrapyrrole_binding HEBP1 GO:0016109 tetraterpenoid_biosynthesis IDI1 GO:0016108 tetraterpenoid_metabolism IDI1 GO:0042088 T-helper_1_type_immune_response INHA GO:0001659 thermoregulation PTGER3 GO:0015888 thiamin_transport SLC19A2 GO:0015234 thiamin_transporter_activity SLC19A2 GO:0016790 thiolester_hydrolase_activity BAP1 GO:0003809 thrombin_activity F2 GO:0004797 thymidine_kinase_activity TK1 GO:0006590 thyroid_hormone_generation TTR GO:0042403 thyroid_hormone_metabolism TTR GO:0005923 tight_junction PMP22 GO:0008483 transaminase_activity BCAT1 GO:0008483 transaminase_activity GFPT2 GO:0006350 transcription TLE4 GO:0006350 transcription EPAS1 GO:0006350 transcription TBX3 GO:0006350 transcription SOX30 GO:0006350 transcription MID1 GO:0006350 transcription MTA3 GO:0006350 transcription TRPS1 GO:0006350 transcription PAX5 GO:0006350 transcription SALL1 GO:0006350 transcription CDK8 GO:0006350 transcription POU5F1 GO:0006350 transcription AHR GO:0006350 transcription PPP1R12B GO:0006350 transcription PAX3 GO:0006350 transcription CEBPD GO:0006350 transcription AES GO:0006350 transcription DDX20 GO:0006350 transcription TLE1 GO:0006350 transcription TCF7L2 GO:0006350 transcription NR2F1 GO:0006350 transcription FEM1B GO:0006350 transcription HEY1 GO:0006350 transcription SIRT7 GO:0006350 transcription TBX2 GO:0006350 transcription CITED1 GO:0006350 transcription SHOX2 GO:0006350 transcription BHLHB3 GO:0006350 transcription EMX2 GO:0006350 transcription ATBF1 GO:0006350 transcription BAZ1B GO:0006350 transcription TCEA2 GO:0006350 transcription SOX14 GO:0006350 transcription KLF12 GO:0006350 transcription TLX2 GO:0006350 transcription MLL GO:0006350 transcription APEH GO:0006350 transcription ETS2 GO:0006350 transcription CBFB GO:0006350 transcription HMGB2 GO:0006350 transcription HESX1 GO:0006350 transcription ARID3A

149:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006350 transcription NSEP1 GO:0006350 transcription ARNTL GO:0006350 transcription HNF3B GO:0006350 transcription AR GO:0006350 transcription FOXA1 GO:0006350 transcription TCF8 GO:0006350 transcription HES7 GO:0006350 transcription ACE2 GO:0006350 transcription FHL2 GO:0006350 transcription NFIA GO:0006351 transcription,_DNA-dependent TLE4 GO:0006351 transcription,_DNA-dependent EPAS1 GO:0006351 transcription,_DNA-dependent TBX3 GO:0006351 transcription,_DNA-dependent SOX30 GO:0006351 transcription,_DNA-dependent MID1 GO:0006351 transcription,_DNA-dependent MTA3 GO:0006351 transcription,_DNA-dependent TRPS1 GO:0006351 transcription,_DNA-dependent SALL1 GO:0006351 transcription,_DNA-dependent PAX5 GO:0006351 transcription,_DNA-dependent CDK8 GO:0006351 transcription,_DNA-dependent POU5F1 GO:0006351 transcription,_DNA-dependent AHR GO:0006351 transcription,_DNA-dependent PPP1R12B GO:0006351 transcription,_DNA-dependent CEBPD GO:0006351 transcription,_DNA-dependent PAX3 GO:0006351 transcription,_DNA-dependent AES GO:0006351 transcription,_DNA-dependent DDX20 GO:0006351 transcription,_DNA-dependent TCF7L2 GO:0006351 transcription,_DNA-dependent TLE1 GO:0006351 transcription,_DNA-dependent NR2F1 GO:0006351 transcription,_DNA-dependent FEM1B GO:0006351 transcription,_DNA-dependent HEY1 GO:0006351 transcription,_DNA-dependent SIRT7 GO:0006351 transcription,_DNA-dependent TBX2 GO:0006351 transcription,_DNA-dependent SHOX2 GO:0006351 transcription,_DNA-dependent BHLHB3 GO:0006351 transcription,_DNA-dependent EMX2 GO:0006351 transcription,_DNA-dependent ATBF1 GO:0006351 transcription,_DNA-dependent BAZ1B GO:0006351 transcription,_DNA-dependent TCEA2 GO:0006351 transcription,_DNA-dependent SOX14 GO:0006351 transcription,_DNA-dependent KLF12 GO:0006351 transcription,_DNA-dependent TLX2 GO:0006351 transcription,_DNA-dependent MLL GO:0006351 transcription,_DNA-dependent APEH GO:0006351 transcription,_DNA-dependent ETS2 GO:0006351 transcription,_DNA-dependent CBFB GO:0006351 transcription,_DNA-dependent HMGB2 GO:0006351 transcription,_DNA-dependent HESX1 GO:0006351 transcription,_DNA-dependent ARID3A GO:0006351 transcription,_DNA-dependent NSEP1 GO:0006351 transcription,_DNA-dependent ARNTL GO:0006351 transcription,_DNA-dependent HNF3B GO:0006351 transcription,_DNA-dependent AR GO:0006351 transcription,_DNA-dependent FOXA1 GO:0006351 transcription,_DNA-dependent TCF8 GO:0006351 transcription,_DNA-dependent HES7 GO:0006351 transcription,_DNA-dependent ACE2 GO:0006351 transcription,_DNA-dependent FHL2 GO:0006351 transcription,_DNA-dependent NFIA GO:0003713 transcription_coactivator_activity CBFB

150:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0003713 transcription_coactivator_activity PCBD GO:0003712 transcription_cofactor_activity CBFB GO:0003712 transcription_cofactor_activity TLE4 GO:0003712 transcription_cofactor_activity BHLHB3 GO:0003712 transcription_cofactor_activity AES GO:0003712 transcription_cofactor_activity PCBD GO:0003714 transcription_corepressor_activity TLE4 GO:0003714 transcription_corepressor_activity AES GO:0003714 transcription_corepressor_activity BHLHB3 GO:0003700 transcription_factor_activity TCEA2 GO:0003700 transcription_factor_activity EPAS1 GO:0003700 transcription_factor_activity SOX14 GO:0003700 transcription_factor_activity TBX3 GO:0003700 transcription_factor_activity TLX2 GO:0003700 transcription_factor_activity APEH GO:0003700 transcription_factor_activity SOX30 GO:0003700 transcription_factor_activity ETS2 GO:0003700 transcription_factor_activity MTA3 GO:0003700 transcription_factor_activity TRPS1 GO:0003700 transcription_factor_activity HESX1 GO:0003700 transcription_factor_activity PAX5 GO:0003700 transcription_factor_activity POU5F1 GO:0003700 transcription_factor_activity AHR GO:0003700 transcription_factor_activity PPP1R12B GO:0003700 transcription_factor_activity HNF3B GO:0003700 transcription_factor_activity ARNTL GO:0003700 transcription_factor_activity PAX3 GO:0003700 transcription_factor_activity AR GO:0003700 transcription_factor_activity TCF7L2 GO:0003700 transcription_factor_activity NR2F1 GO:0003700 transcription_factor_activity FEM1B GO:0003700 transcription_factor_activity HEY1 GO:0003700 transcription_factor_activity TBX2 GO:0003700 transcription_factor_activity FOXA1 GO:0003700 transcription_factor_activity SHOX2 GO:0003700 transcription_factor_activity TCF8 GO:0003700 transcription_factor_activity EMX2 GO:0003700 transcription_factor_activity ATBF1 GO:0003700 transcription_factor_activity NFIA GO:0008134 transcription_factor_binding CBFB GO:0008134 transcription_factor_binding TLE4 GO:0008134 transcription_factor_binding PCBD GO:0008134 transcription_factor_binding AES GO:0008134 transcription_factor_binding BHLHB3 GO:0005667 transcription_factor_complex AHR GO:0005667 transcription_factor_complex HNF3B GO:0005667 transcription_factor_complex PAX3 GO:0005667 transcription_factor_complex SOX14 GO:0005667 transcription_factor_complex TLX2 GO:0005667 transcription_factor_complex TCF7L2 GO:0005667 transcription_factor_complex NR2F1 GO:0005667 transcription_factor_complex SOX30 GO:0005667 transcription_factor_complex CBFB GO:0005667 transcription_factor_complex TBX2 GO:0005667 transcription_factor_complex FOXA1 GO:0005667 transcription_factor_complex SHOX2 GO:0005667 transcription_factor_complex HESX1 GO:0005667 transcription_factor_complex PAX5 GO:0006366 transcription_from_Pol_II_promoter AHR GO:0006366 transcription_from_Pol_II_promoter CBFB GO:0006366 transcription_from_Pol_II_promoter TBX2

151:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006366 transcription_from_Pol_II_promoter SOX14 GO:0006366 transcription_from_Pol_II_promoter BHLHB3 GO:0006366 transcription_from_Pol_II_promoter ACE2 GO:0006366 transcription_from_Pol_II_promoter HES7 GO:0006366 transcription_from_Pol_II_promoter DDX20 GO:0006366 transcription_from_Pol_II_promoter TLE1 GO:0006366 transcription_from_Pol_II_promoter CDK8 GO:0006366 transcription_from_Pol_II_promoter FHL2 GO:0006366 transcription_from_Pol_II_promoter POU5F1 GO:0006352 transcription_initiation CDK8 GO:0006367 transcription_initiation_from_Pol_II_promoter CDK8 GO:0030528 transcription_regulator_activity TCEA2 GO:0030528 transcription_regulator_activity TLE4 GO:0030528 transcription_regulator_activity EPAS1 GO:0030528 transcription_regulator_activity SOX14 GO:0030528 transcription_regulator_activity TBX3 GO:0030528 transcription_regulator_activity TLX2 GO:0030528 transcription_regulator_activity SOX30 GO:0030528 transcription_regulator_activity APEH GO:0030528 transcription_regulator_activity ETS2 GO:0030528 transcription_regulator_activity CBFB GO:0030528 transcription_regulator_activity MTA3 GO:0030528 transcription_regulator_activity TRPS1 GO:0030528 transcription_regulator_activity HESX1 GO:0030528 transcription_regulator_activity PAX5 GO:0030528 transcription_regulator_activity CDK8 GO:0030528 transcription_regulator_activity POU5F1 GO:0030528 transcription_regulator_activity AHR GO:0030528 transcription_regulator_activity PPP1R12B GO:0030528 transcription_regulator_activity HNF3B GO:0030528 transcription_regulator_activity ARNTL GO:0030528 transcription_regulator_activity PAX3 GO:0030528 transcription_regulator_activity PCBD GO:0030528 transcription_regulator_activity AES GO:0030528 transcription_regulator_activity AR GO:0030528 transcription_regulator_activity DDX20 GO:0030528 transcription_regulator_activity TCF7L2 GO:0030528 transcription_regulator_activity NR2F1 GO:0030528 transcription_regulator_activity FEM1B GO:0030528 transcription_regulator_activity HEY1 GO:0030528 transcription_regulator_activity SIRT7 GO:0030528 transcription_regulator_activity TBX2 GO:0030528 transcription_regulator_activity CITED1 GO:0030528 transcription_regulator_activity SHOX2 GO:0030528 transcription_regulator_activity FOXA1 GO:0030528 transcription_regulator_activity BHLHB3 GO:0030528 transcription_regulator_activity TCF8 GO:0030528 transcription_regulator_activity HES7 GO:0030528 transcription_regulator_activity ACE2 GO:0030528 transcription_regulator_activity ATBF1 GO:0030528 transcription_regulator_activity EMX2 GO:0030528 transcription_regulator_activity NFIA GO:0016563 transcriptional_activator_activity ACE2 GO:0016563 transcriptional_activator_activity NR2F1 GO:0016564 transcriptional_repressor_activity TBX2 GO:0016564 transcriptional_repressor_activity HES7 GO:0016564 transcriptional_repressor_activity DDX20 GO:0017053 transcriptional_repressor_complex BHLHB3 GO:0017053 transcriptional_repressor_complex DDX20 GO:0016740 transferase_activity PRKAA1 GO:0016740 transferase_activity GSTP1

152:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0016740 transferase_activity GK2 GO:0016740 transferase_activity UMPK GO:0016740 transferase_activity GSTA1 GO:0016740 transferase_activity HS2ST1 GO:0016740 transferase_activity SIAT4C GO:0016740 transferase_activity GSTM3 GO:0016740 transferase_activity EKI1 GO:0016740 transferase_activity DNMT3B GO:0016740 transferase_activity MGST2 GO:0016740 transferase_activity ATIC GO:0016740 transferase_activity OCA2 GO:0016740 transferase_activity GSTA2 GO:0016740 transferase_activity GGTLA1 GO:0016740 transferase_activity PGK1 GO:0016740 transferase_activity MAPK4 GO:0016740 transferase_activity TPST2 GO:0016740 transferase_activity CKB GO:0016740 transferase_activity EPHA3 GO:0016740 transferase_activity CDK8 GO:0016740 transferase_activity MGST1 GO:0016740 transferase_activity WBSCR22 GO:0016740 transferase_activity SULT1E1 GO:0016740 transferase_activity NRBP GO:0016740 transferase_activity MAP3K5 GO:0016740 transferase_activity GGPS1 GO:0016740 transferase_activity MGAT5 GO:0016740 transferase_activity CKMT2 GO:0016740 transferase_activity BCAT1 GO:0016740 transferase_activity TK1 GO:0016740 transferase_activity PRKAR2A GO:0016740 transferase_activity ART3 GO:0016740 transferase_activity TESK2 GO:0016740 transferase_activity GNE GO:0016740 transferase_activity BAP1 GO:0016740 transferase_activity MSN GO:0016740 transferase_activity FEN1 GO:0016740 transferase_activity CCT2 GO:0016740 transferase_activity UPP1 GO:0016740 transferase_activity ROR1 GO:0016740 transferase_activity GFPT2 GO:0016746 transferase_activity,_transferring_acyl_groups GGTLA1 GO:0016746 transferase_activity,_transferring_acyl_groups BAP1 GO:0016746 transferase_activity,_transferring_acyl_groups FEN1 GO:0046912 transferase_activity,_transferring_acyl_groups,_acyl_groups_converted_into_alkylBAP1 GO:0016765 transferase_activity,_transferring_alkyl_or_aryl_(other_than_methyl)_groups GSTA2 GO:0016765 transferase_activity,_transferring_alkyl_or_aryl_(other_than_methyl)_groups GSTP1 GO:0016765 transferase_activity,_transferring_alkyl_or_aryl_(other_than_methyl)_groups GSTA1 GO:0016765 transferase_activity,_transferring_alkyl_or_aryl_(other_than_methyl)_groups GSTM3 GO:0016765 transferase_activity,_transferring_alkyl_or_aryl_(other_than_methyl)_groups MGST1 GO:0016765 transferase_activity,_transferring_alkyl_or_aryl_(other_than_methyl)_groups GGPS1 GO:0016755 transferase_activity,_transferring_amino-acyl_groups GGTLA1 GO:0016757 transferase_activity,_transferring_glycosyl_groups ART3 GO:0016757 transferase_activity,_transferring_glycosyl_groups MGAT5 GO:0016757 transferase_activity,_transferring_glycosyl_groups SIAT4C GO:0016757 transferase_activity,_transferring_glycosyl_groups UPP1 GO:0016747 transferase_activity,_transferring_groups_other_than_amino-acyl_groups GGTLA1 GO:0016747 transferase_activity,_transferring_groups_other_than_amino-acyl_groups FEN1 GO:0016758 transferase_activity,_transferring_hexosyl_groups MGAT5 GO:0016769 transferase_activity,_transferring_nitrogenous_groups BCAT1 GO:0016769 transferase_activity,_transferring_nitrogenous_groups GFPT2 GO:0016741 transferase_activity,_transferring_one-carbon_groups ATIC

153:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0016741 transferase_activity,_transferring_one-carbon_groups WBSCR22 GO:0016741 transferase_activity,_transferring_one-carbon_groups DNMT3B GO:0016763 transferase_activity,_transferring_pentosyl_groups ART3 GO:0016763 transferase_activity,_transferring_pentosyl_groups UPP1 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups CKMT2 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups PRKAA1 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups GK2 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups UMPK GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups TK1 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups EKI1 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups PRKAR2A GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups OCA2 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups TESK2 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups MAPK4 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups PGK1 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups MSN GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups CKB GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups CCT2 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups CDK8 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups EPHA3 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups MAP3K5 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups ROR1 GO:0016772 transferase_activity,_transferring_phosphorus-containing_groups NRBP GO:0016782 transferase_activity,_transferring_sulfur-containing_groups TPST2 GO:0016782 transferase_activity,_transferring_sulfur-containing_groups HS2ST1 GO:0016782 transferase_activity,_transferring_sulfur-containing_groups SULT1E1 GO:0007179 transforming_growth_factor_beta_receptor_signaling_pathway BMP2 GO:0007179 transforming_growth_factor_beta_receptor_signaling_pathway BAMBI GO:0007179 transforming_growth_factor_beta_receptor_signaling_pathway CHRDL2 GO:0030140 trans-Golgi_network_transport_vesicle APM2 GO:0046914 transition_metal_ion_binding MMP11 GO:0046914 transition_metal_ion_binding KLF12 GO:0046914 transition_metal_ion_binding PRND GO:0046914 transition_metal_ion_binding MT1A GO:0046914 transition_metal_ion_binding MLL GO:0046914 transition_metal_ion_binding TRAF5 GO:0046914 transition_metal_ion_binding AFP GO:0046914 transition_metal_ion_binding MID1 GO:0046914 transition_metal_ion_binding LOXL1 GO:0046914 transition_metal_ion_binding TRPS1 GO:0046914 transition_metal_ion_binding FN1 GO:0046914 transition_metal_ion_binding PRNP GO:0046914 transition_metal_ion_binding FEN1 GO:0046914 transition_metal_ion_binding ENPEP GO:0046914 transition_metal_ion_binding MT2A GO:0046914 transition_metal_ion_binding SORL1 GO:0046914 transition_metal_ion_binding ADAMTS19 GO:0046914 transition_metal_ion_binding TCF8 GO:0046914 transition_metal_ion_binding PPP6C GO:0046914 transition_metal_ion_binding ATBF1 GO:0046914 transition_metal_ion_binding SALL1 GO:0046914 transition_metal_ion_binding RNPEP GO:0046916 transition_metal_ion_homeostasis PRNP GO:0046916 transition_metal_ion_homeostasis MT2A GO:0046916 transition_metal_ion_homeostasis MT1A GO:0046916 transition_metal_ion_homeostasis PRND GO:0043037 translation NARS GO:0043037 translation WARS GO:0043037 translation CDH16 GO:0043037 translation EIF3S5 GO:0003746 translation_elongation_factor_activity TCEA2

154:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008135 translation_factor_activity,_nucleic_acid_binding TCEA2 GO:0008135 translation_factor_activity,_nucleic_acid_binding EIF3S5 GO:0003743 translation_initiation_factor_activity EIF3S5 GO:0045182 translation_regulator_activity YBX2 GO:0045182 translation_regulator_activity TCEA2 GO:0045182 translation_regulator_activity EIF3S5 GO:0006413 translational_initiation EIF3S5 GO:0004888 transmembrane_receptor_activity FZD7 GO:0004888 transmembrane_receptor_activity GPC4 GO:0004888 transmembrane_receptor_activity GRIN2D GO:0004888 transmembrane_receptor_activity DSCAM GO:0004888 transmembrane_receptor_activity PTGER3 GO:0004888 transmembrane_receptor_activity HNRPM GO:0004888 transmembrane_receptor_activity IFNGR2 GO:0004888 transmembrane_receptor_activity FZD4 GO:0004888 transmembrane_receptor_activity BRS3 GO:0004888 transmembrane_receptor_activity TNFRSF1A GO:0004888 transmembrane_receptor_activity GPR6 GO:0004888 transmembrane_receptor_activity INSL3 GO:0004888 transmembrane_receptor_activity PTPRR GO:0004888 transmembrane_receptor_activity SLC19A2 GO:0004888 transmembrane_receptor_activity GPR45 GO:0004888 transmembrane_receptor_activity IL27RA GO:0004888 transmembrane_receptor_activity TLR8 GO:0004888 transmembrane_receptor_activity ADORA2B GO:0004888 transmembrane_receptor_activity LRP10 GO:0004888 transmembrane_receptor_activity CLEC2 GO:0004888 transmembrane_receptor_activity EPHA3 GO:0004888 transmembrane_receptor_activity ROR1 GO:0004888 transmembrane_receptor_activity CCKBR GO:0004888 transmembrane_receptor_activity AGTRAP GO:0019199 transmembrane_receptor_protein_kinase_activity EPHA3 GO:0019199 transmembrane_receptor_protein_kinase_activity ROR1 GO:0019198 transmembrane_receptor_protein_phosphatase_activity PTPRR GO:0007178 transmembrane_receptor_protein_serine/threonine_kinase_signaling_pathway BMP2 GO:0007178 transmembrane_receptor_protein_serine/threonine_kinase_signaling_pathway BAMBI GO:0007178 transmembrane_receptor_protein_serine/threonine_kinase_signaling_pathway CHRDL2 GO:0004714 transmembrane_receptor_protein_tyrosine_kinase_activity EPHA3 GO:0004714 transmembrane_receptor_protein_tyrosine_kinase_activity ROR1 GO:0005069 transmembrane_receptor_protein_tyrosine_kinase_docking_protein_activity GRB14 GO:0007169 transmembrane_receptor_protein_tyrosine_kinase_signaling_pathway ANGPTL1 GO:0007169 transmembrane_receptor_protein_tyrosine_kinase_signaling_pathway EPHA3 GO:0007169 transmembrane_receptor_protein_tyrosine_kinase_signaling_pathway IGF1 GO:0005066 transmembrane_receptor_protein_tyrosine_kinase_signaling_protein_activity GRB14 GO:0005001 transmembrane_receptor_protein_tyrosine_phosphatase_activity PTPRR GO:0007185 transmembrane_receptor_protein_tyrosine_phosphatase_signaling_pathway PTPRD GO:0007185 transmembrane_receptor_protein_tyrosine_phosphatase_signaling_pathway PTPRK GO:0007185 transmembrane_receptor_protein_tyrosine_phosphatase_signaling_pathway PTPRR GO:0019226 transmission_of_nerve_impulse GNA11 GO:0019226 transmission_of_nerve_impulse CART GO:0019226 transmission_of_nerve_impulse GRIN2D GO:0019226 transmission_of_nerve_impulse APM2 GO:0019226 transmission_of_nerve_impulse CLC GO:0006810 transport CLIC6 GO:0006810 transport PTGER3 GO:0006810 transport STAR GO:0006810 transport STX6 GO:0006810 transport LRRN3 GO:0006810 transport MID1 GO:0006810 transport FOLR1 GO:0006810 transport SLC7A11

155:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006810 transport PDZK1 GO:0006810 transport SLC2A3 GO:0006810 transport POU5F1 GO:0006810 transport AP2B1 GO:0006810 transport GRIN2D GO:0006810 transport VLDLR GO:0006810 transport SLC19A2 GO:0006810 transport APOE GO:0006810 transport TTR GO:0006810 transport DNCL2A GO:0006810 transport CLC GO:0006810 transport SLCO4A1 GO:0006810 transport APOB GO:0006810 transport GFPT2 GO:0006810 transport PRKAA1 GO:0006810 transport COPE GO:0006810 transport ARL4 GO:0006810 transport SCN9A GO:0006810 transport ATP1B1 GO:0006810 transport ATP6V1E2 GO:0006810 transport AFP GO:0006810 transport FABP5 GO:0006810 transport FXYD6 GO:0006810 transport CDH17 GO:0006810 transport APM2 GO:0006810 transport CACNA1C GO:0006810 transport SLC19A1 GO:0006810 transport APOA2 GO:0006810 transport CADPS2 GO:0006810 transport ATP12A GO:0006810 transport SLC2A1 GO:0006810 transport HDLBP GO:0006810 transport ANXA4 GO:0006810 transport SLC17A1 GO:0006810 transport ARNTL GO:0006810 transport PRKAR2A GO:0006810 transport PTGDS GO:0006810 transport AMBP GO:0006810 transport SLCO2A1 GO:0006810 transport FEN1 GO:0006810 transport SORL1 GO:0006810 transport LRP10 GO:0030133 transport_vesicle AP2B1 GO:0030133 transport_vesicle APM2 GO:0005215 transporter_activity COPE GO:0005215 transporter_activity ARL4 GO:0005215 transporter_activity CLIC6 GO:0005215 transporter_activity STAR GO:0005215 transporter_activity STX6 GO:0005215 transporter_activity COX7C GO:0005215 transporter_activity SCN9A GO:0005215 transporter_activity ATP1B1 GO:0005215 transporter_activity MLL GO:0005215 transporter_activity ATP6V1E2 GO:0005215 transporter_activity AFP GO:0005215 transporter_activity FABP5 GO:0005215 transporter_activity OCA2 GO:0005215 transporter_activity MID1 GO:0005215 transporter_activity FXYD6 GO:0005215 transporter_activity FOLR1 GO:0005215 transporter_activity CDH17

156:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0005215 transporter_activity COX6A2 GO:0005215 transporter_activity CBR1 GO:0005215 transporter_activity SLC7A11 GO:0005215 transporter_activity CACNA1C GO:0005215 transporter_activity SLC2A3 GO:0005215 transporter_activity SLC19A1 GO:0005215 transporter_activity APOA2 GO:0005215 transporter_activity ROPN1 GO:0005215 transporter_activity ATP12A GO:0005215 transporter_activity AP2B1 GO:0005215 transporter_activity SLC2A1 GO:0005215 transporter_activity HDLBP GO:0005215 transporter_activity SLC17A1 GO:0005215 transporter_activity GRIN2D GO:0005215 transporter_activity PRKAR2A GO:0005215 transporter_activity TBPL1 GO:0005215 transporter_activity PTGDS GO:0005215 transporter_activity VLDLR GO:0005215 transporter_activity SLC19A2 GO:0005215 transporter_activity AMBP GO:0005215 transporter_activity NDUFB9 GO:0005215 transporter_activity LOXL1 GO:0005215 transporter_activity APOE GO:0005215 transporter_activity TTR GO:0005215 transporter_activity SLCO2A1 GO:0005215 transporter_activity SORL1 GO:0005215 transporter_activity SLCO4A1 GO:0005215 transporter_activity CLC GO:0005215 transporter_activity GFPT2 GO:0006641 triacylglycerol_metabolism GK2 GO:0006641 triacylglycerol_metabolism APOB GO:0006642 triacylglycerol_mobilization APOB GO:0006099 tricarboxylic_acid_cycle SUCLA2 GO:0043039 tRNA_aminoacylation NARS GO:0043039 tRNA_aminoacylation WARS GO:0043039 tRNA_aminoacylation CDH16 GO:0006418 tRNA_aminoacylation_for_protein_translation NARS GO:0006418 tRNA_aminoacylation_for_protein_translation WARS GO:0006418 tRNA_aminoacylation_for_protein_translation CDH16 GO:0004812 tRNA_ligase_activity NARS GO:0004812 tRNA_ligase_activity WARS GO:0004812 tRNA_ligase_activity CDH16 GO:0006399 tRNA_metabolism NARS GO:0006399 tRNA_metabolism WARS GO:0006399 tRNA_metabolism CDH16 GO:0006400 tRNA_modification NARS GO:0006400 tRNA_modification WARS GO:0006400 tRNA_modification CDH16 GO:0005861 troponin_complex TNNT3 GO:0004295 trypsin_activity F2 GO:0004295 trypsin_activity PLAT GO:0004295 trypsin_activity C1R GO:0006569 tryptophan_catabolism INDO GO:0019441 tryptophan_catabolism_to_kynurenine INDO GO:0006568 tryptophan_metabolism INDO GO:0004830 tryptophan-tRNA_ligase_activity WARS GO:0006436 tryptophanyl-tRNA_aminoacylation WARS GO:0030315 T-tubule CACNA1C GO:0015631 tubulin_binding STMN1 GO:0015631 tubulin_binding SPAG5 GO:0007021 tubulin_folding CCT2

157:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0043120 tumor_necrosis_factor_binding TNFRSF1A GO:0005031 tumor_necrosis_factor_receptor_activity TNFRSF1A GO:0005164 tumor_necrosis_factor_receptor_binding TNFRSF1A GO:0004839 ubiquitin_activating_enzyme_activity UBA2 GO:0006512 ubiquitin_cycle UBA2 GO:0006512 ubiquitin_cycle BAP1 GO:0000151 ubiquitin_ligase_complex CUL1 GO:0004221 ubiquitin_thiolesterase_activity BAP1 GO:0006511 ubiquitin-dependent_protein_catabolism BAP1 GO:0008642 ubiquitin-like_activating_enzyme_activity UBA2 GO:0004842 ubiquitin-protein_ligase_activity RNF128 GO:0004843 ubiquitin-specific_protease_activity BAP1 GO:0008761 UDP-N-acetylglucosamine_2-epimerase_activity GNE GO:0006047 UDP-N-acetylglucosamine_metabolism GNE GO:0005941 unlocalized PRKAR2B GO:0005941 unlocalized PGK1 GO:0005941 unlocalized PAICS GO:0005941 unlocalized GLB1 GO:0005941 unlocalized PRKAR2A GO:0004849 uridine_kinase_activity UMPK GO:0004850 uridine_phosphorylase_activity UPP1 GO:0001655 urogenital_system_development ANXA4 GO:0005773 vacuole CPR8 GO:0005773 vacuole GALC GO:0005773 vacuole GLB1 GO:0005773 vacuole GLA GO:0005773 vacuole MT1A GO:0005773 vacuole ATP6V1E2 GO:0000324 vacuole_(sensu_Fungi) CPR8 GO:0030120 vesicle_coat AP2B1 GO:0030120 vesicle_coat APM2 GO:0030120 vesicle_coat CLC GO:0016192 vesicle-mediated_transport LRRN3 GO:0016192 vesicle-mediated_transport AP2B1 GO:0016192 vesicle-mediated_transport ANXA4 GO:0016192 vesicle-mediated_transport FEN1 GO:0016192 vesicle-mediated_transport APM2 GO:0016192 vesicle-mediated_transport SORL1 GO:0016192 vesicle-mediated_transport STX6 GO:0016192 vesicle-mediated_transport LRP10 GO:0016192 vesicle-mediated_transport CLC GO:0016192 vesicle-mediated_transport VLDLR GO:0016192 vesicle-mediated_transport CADPS2 GO:0042598 vesicular_fraction PTGES GO:0042598 vesicular_fraction AMBP GO:0042598 vesicular_fraction TAPBP GO:0042598 vesicular_fraction CBR1 GO:0042598 vesicular_fraction CYP26A1 GO:0042598 vesicular_fraction MGST1 GO:0042598 vesicular_fraction APOB GO:0019028 viral_capsid COPE GO:0019012 virion COPE GO:0007601 visual_perception NR2F1 GO:0015875 vitamin/cofactor_transport SLC19A2 GO:0015223 vitamin/cofactor_transporter_activity SLC19A2 GO:0015223 vitamin/cofactor_transporter_activity FOLR1 GO:0019842 vitamin_binding SLC19A2 GO:0019842 vitamin_binding FOLR1 GO:0019842 vitamin_binding TTR GO:0019842 vitamin_binding SLC19A1 GO:0042359 vitamin_D_metabolism CALB1

158:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006766 vitamin_metabolism TMLHE GO:0006766 vitamin_metabolism CALB1 GO:0006766 vitamin_metabolism FOLR1 GO:0005245 voltage-gated_calcium_channel_activity CACNA1C GO:0005891 voltage-gated_calcium_channel_complex CACNA1C GO:0005247 voltage-gated_chloride_channel_activity CLIC6 GO:0005244 voltage-gated_ion_channel_activity CLIC6 GO:0005244 voltage-gated_ion_channel_activity CACNA1C GO:0005244 voltage-gated_ion_channel_activity SCN9A GO:0005248 voltage-gated_sodium_channel_activity SCN9A GO:0001518 voltage-gated_sodium_channel_complex SCN9A GO:0006767 water-soluble_vitamin_metabolism TMLHE GO:0006767 water-soluble_vitamin_metabolism FOLR1 GO:0016055 Wnt_receptor_signaling_pathway FZD7 GO:0016055 Wnt_receptor_signaling_pathway CXXC4 GO:0016055 Wnt_receptor_signaling_pathway TLE4 GO:0016055 Wnt_receptor_signaling_pathway FZD4 GO:0016055 Wnt_receptor_signaling_pathway TCF7L2 GO:0016055 Wnt_receptor_signaling_pathway TLE1 GO:0016055 Wnt_receptor_signaling_pathway DKK1 GO:0017147 Wnt-protein_binding DKK1 GO:0042060 wound_healing F2 GO:0042060 wound_healing FN1 GO:0006805 xenobiotic_metabolism AHR GO:0006805 xenobiotic_metabolism GSTP1 GO:0008270 zinc_ion_binding MMP11 GO:0008270 zinc_ion_binding KLF12 GO:0008270 zinc_ion_binding MT1A GO:0008270 zinc_ion_binding MLL GO:0008270 zinc_ion_binding TRAF5 GO:0008270 zinc_ion_binding MID1 GO:0008270 zinc_ion_binding TRPS1 GO:0008270 zinc_ion_binding ENPEP GO:0008270 zinc_ion_binding TCF8 GO:0008270 zinc_ion_binding ADAMTS19 GO:0008270 zinc_ion_binding SALL1 GO:0008270 zinc_ion_binding ATBF1 GO:0008270 zinc_ion_binding RNPEP GO:0006882 zinc_ion_homeostasis MT1A GO:0000238 zygotene SYCP2

159:159 Skotheim et al., Supplementary Table 2B