Supplementary Table 2B. The actual genes involved in each gene ontology term among a set of 687 inter- histological subtype-regulated genes. GO_ID Gene ontology Gene Symbol GO:0030552 3',5'-cAMP_binding PRKAR2B GO:0030552 3',5'-cAMP_binding PRKAR2A GO:0003854 3-beta-hydroxy-delta5-steroid_dehydrogenase_activity HSD3B2 GO:0003854 3-beta-hydroxy-delta5-steroid_dehydrogenase_activity HSD3B1 GO:0008124 4-alpha-hydroxytetrahydrobiopterin_dehydratase_activity PCBD GO:0017168 5-oxoprolinase_(ATP-hydrolyzing)_activity OPLAH GO:0008413 8-oxo-7,8-dihydroguanine_triphosphatase_activity NUDT1 GO:0001612 A2B_adenosine_receptor_activity,_G-protein_coupled ADORA2B GO:0019413 acetate_biosynthesis ACAS2L GO:0006083 acetate_metabolism ACAS2L GO:0003987 acetate-CoA_ligase_activity ACAS2L GO:0006085 acetyl-CoA_biosynthesis ACAS2L GO:0006084 acetyl-CoA_metabolism ACAS2L GO:0008375 acetylglucosaminyltransferase_activity MGAT5 GO:0016881 acid-D-amino_acid_ligase_activity PAICS GO:0016881 acid-D-amino_acid_ligase_activity RNF128 GO:0016878 acid-thiol_ligase_activity SUCLA2 GO:0016878 acid-thiol_ligase_activity ACAS2L GO:0001669 acrosome ATP6V1E2 GO:0001675 acrosome_formation TBPL1 GO:0003779 actin_binding CAPZA3 GO:0003779 actin_binding MYH11 GO:0003779 actin_binding ARPC1A GO:0003779 actin_binding PLS3 GO:0003779 actin_binding CAPZB GO:0015629 actin_cytoskeleton MYH11 GO:0015629 actin_cytoskeleton CAPZA3 GO:0015629 actin_cytoskeleton ARPC1A GO:0015629 actin_cytoskeleton TNNT3 GO:0015629 actin_cytoskeleton MYOZ2 GO:0015629 actin_cytoskeleton CCT2 GO:0015629 actin_cytoskeleton CAPZB GO:0030036 actin_cytoskeleton_organization_and_biogenesis CAPZA3 GO:0030036 actin_cytoskeleton_organization_and_biogenesis ARPC1A GO:0030036 actin_cytoskeleton_organization_and_biogenesis PLS3 GO:0030036 actin_cytoskeleton_organization_and_biogenesis CAPZB GO:0030036 actin_cytoskeleton_organization_and_biogenesis ELN GO:0051017 actin_filament_bundle_formation ELN GO:0007015 actin_filament_organization ARPC1A GO:0007015 actin_filament_organization PLS3 GO:0007015 actin_filament_organization ELN GO:0030041 actin_filament_polymerization ELN GO:0030029 actin_filament-based_process CAPZA3 GO:0030029 actin_filament-based_process ARPC1A GO:0030029 actin_filament-based_process PLS3 GO:0030029 actin_filament-based_process CAPZB GO:0030029 actin_filament-based_process ELN GO:0008154 actin_polymerization_and/or_depolymerization ELN GO:0000187 activation_of_MAPK LRRN3 GO:0000187 activation_of_MAPK PRKAA1 GO:0000185 activation_of_MAPKKK MSN GO:0017106 activin_inhibitor_activity INHA GO:0006953 acute-phase_response F2 GO:0006953 acute-phase_response FN1 GO:0006953 acute-phase_response PAP GO:0004254 acylaminoacyl-peptidase_activity APEH GO:0006639 acylglycerol_metabolism GK2 GO:0006639 acylglycerol_metabolism APOB GO:0008415 acyltransferase_activity GGTLA1 1:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0008415 acyltransferase_activity FEN1 GO:0004000 adenosine_deaminase_activity TENR GO:0001609 adenosine_receptor_activity,_G-protein_coupled ADORA2B GO:0030554 adenyl_nucleotide_binding PRKAA1 GO:0030554 adenyl_nucleotide_binding GK2 GO:0030554 adenyl_nucleotide_binding PRKAR2B GO:0030554 adenyl_nucleotide_binding NARS GO:0030554 adenyl_nucleotide_binding UMPK GO:0030554 adenyl_nucleotide_binding OCA2 GO:0030554 adenyl_nucleotide_binding MAPK4 GO:0030554 adenyl_nucleotide_binding WARS GO:0030554 adenyl_nucleotide_binding ITM2B GO:0030554 adenyl_nucleotide_binding CDK8 GO:0030554 adenyl_nucleotide_binding EPHA3 GO:0030554 adenyl_nucleotide_binding MAP3K5 GO:0030554 adenyl_nucleotide_binding NRBP GO:0030554 adenyl_nucleotide_binding MYH11 GO:0030554 adenyl_nucleotide_binding ATP12A GO:0030554 adenyl_nucleotide_binding SLC2A1 GO:0030554 adenyl_nucleotide_binding CDH16 GO:0030554 adenyl_nucleotide_binding TK1 GO:0030554 adenyl_nucleotide_binding DDX20 GO:0030554 adenyl_nucleotide_binding PRKAR2A GO:0030554 adenyl_nucleotide_binding DDX25 GO:0030554 adenyl_nucleotide_binding TESK2 GO:0030554 adenyl_nucleotide_binding GNE GO:0030554 adenyl_nucleotide_binding HSPA1A GO:0030554 adenyl_nucleotide_binding CCT2 GO:0030554 adenyl_nucleotide_binding DHX35 GO:0030554 adenyl_nucleotide_binding ROR1 GO:0017045 adrenocorticotropin-releasing_hormone_activity CRH GO:0016284 alanine_aminopeptidase_activity ENPEP GO:0016284 alanine_aminopeptidase_activity RNPEP GO:0008784 alanine_racemase_activity PROSC GO:0046165 alcohol_biosynthesis PRKAA1 GO:0046165 alcohol_biosynthesis PGK1 GO:0046164 alcohol_catabolism SUCLA2 GO:0046164 alcohol_catabolism LDHA GO:0046164 alcohol_catabolism PARG GO:0046164 alcohol_catabolism PGK1 GO:0006066 alcohol_metabolism SUCLA2 GO:0006066 alcohol_metabolism PRKAA1 GO:0006066 alcohol_metabolism GK2 GO:0006066 alcohol_metabolism PARG GO:0006066 alcohol_metabolism HDLBP GO:0006066 alcohol_metabolism EKI1 GO:0006066 alcohol_metabolism VLDLR GO:0006066 alcohol_metabolism LDHA GO:0006066 alcohol_metabolism IDI1 GO:0006066 alcohol_metabolism PGK1 GO:0006066 alcohol_metabolism ALDH1A3 GO:0006066 alcohol_metabolism SORL1 GO:0006066 alcohol_metabolism APOB GO:0004030 aldehyde_dehydrogenase_[NAD(P)+]_activity ALDH1A3 GO:0004028 aldehyde_dehydrogenase_activity ALDH1A3 GO:0004035 alkaline_phosphatase_activity ALPI GO:0030144 alpha-1,6-mannosyl-glycoprotein_6-beta-N-acetylglucosaminyltransferase_activity MGAT5 GO:0004557 alpha-galactosidase_activity GLA GO:0015268 alpha-type_channel_activity MID1 GO:0015268 alpha-type_channel_activity FXYD6 GO:0015268 alpha-type_channel_activity GRIN2D 2:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0015268 alpha-type_channel_activity CLIC6 GO:0015268 alpha-type_channel_activity CACNA1C GO:0015268 alpha-type_channel_activity SCN9A GO:0015837 amine/polyamine_transport SLC7A11 GO:0005275 amine/polyamine_transporter_activity SLC7A11 GO:0009309 amine_biosynthesis TMLHE GO:0009309 amine_biosynthesis BCAT1 GO:0009309 amine_biosynthesis EKI1 GO:0009309 amine_biosynthesis CBS GO:0009310 amine_catabolism INDO GO:0009308 amine_metabolism NARS GO:0009308 amine_metabolism BCAT1 GO:0009308 amine_metabolism PCBD GO:0009308 amine_metabolism CDH16 GO:0009308 amine_metabolism HS2ST1 GO:0009308 amine_metabolism EKI1 GO:0009308 amine_metabolism INDO GO:0009308 amine_metabolism TMLHE GO:0009308 amine_metabolism GNE GO:0009308 amine_metabolism WARS GO:0009308 amine_metabolism TTR GO:0009308 amine_metabolism GFPT2 GO:0009308 amine_metabolism CBS GO:0043038 amino_acid_activation NARS GO:0043038 amino_acid_activation WARS GO:0043038 amino_acid_activation CDH16 GO:0006519 amino_acid_and_derivative_metabolism CKMT2 GO:0006519 amino_acid_and_derivative_metabolism NARS GO:0006519 amino_acid_and_derivative_metabolism BCAT1 GO:0006519 amino_acid_and_derivative_metabolism GLB1 GO:0006519 amino_acid_and_derivative_metabolism PCBD GO:0006519 amino_acid_and_derivative_metabolism CDH16 GO:0006519 amino_acid_and_derivative_metabolism EKI1 GO:0006519 amino_acid_and_derivative_metabolism INDO GO:0006519 amino_acid_and_derivative_metabolism TMLHE GO:0006519 amino_acid_and_derivative_metabolism WARS GO:0006519 amino_acid_and_derivative_metabolism TTR GO:0006519 amino_acid_and_derivative_metabolism CKB GO:0006519 amino_acid_and_derivative_metabolism GFPT2 GO:0006519 amino_acid_and_derivative_metabolism CBS GO:0008652 amino_acid_biosynthesis BCAT1 GO:0008652 amino_acid_biosynthesis CBS GO:0009063 amino_acid_catabolism INDO GO:0042398 amino_acid_derivative_biosynthesis TMLHE GO:0042398 amino_acid_derivative_biosynthesis CKMT2 GO:0042398 amino_acid_derivative_biosynthesis GLB1 GO:0042398 amino_acid_derivative_biosynthesis EKI1 GO:0042219 amino_acid_derivative_catabolism INDO GO:0006575 amino_acid_derivative_metabolism TMLHE GO:0006575 amino_acid_derivative_metabolism CKMT2 GO:0006575 amino_acid_derivative_metabolism GLB1 GO:0006575 amino_acid_derivative_metabolism TTR GO:0006575 amino_acid_derivative_metabolism CKB GO:0006575 amino_acid_derivative_metabolism EKI1 GO:0006575 amino_acid_derivative_metabolism INDO GO:0006520 amino_acid_metabolism NARS GO:0006520 amino_acid_metabolism BCAT1 GO:0006520 amino_acid_metabolism WARS GO:0006520 amino_acid_metabolism PCBD GO:0006520 amino_acid_metabolism CDH16 GO:0006520 amino_acid_metabolism GFPT2 3:159 Skotheim et al., Supplementary Table 2B GO_ID Gene ontology Gene Symbol GO:0006520 amino_acid_metabolism INDO GO:0006520 amino_acid_metabolism CBS GO:0015359 amino_acid_permease_activity SLC7A11 GO:0006865 amino_acid_transport SLC7A11 GO:0015171 amino_acid_transporter_activity SLC7A11 GO:0005279 amino_acid-polyamine_transporter_activity SLC7A11 GO:0006040 amino_sugar_metabolism GNE GO:0006022 aminoglycan_metabolism HS2ST1 GO:0004177 aminopeptidase_activity ENPEP GO:0004177 aminopeptidase_activity RNPEP GO:0030601 aminopeptidase_B_activity RNPEP GO:0016208 AMP_binding PRKAR2B GO:0016208 AMP_binding PRKAR2A GO:0003876 AMP_deaminase_activity AMPD2 GO:0004882 androgen_receptor_activity AR GO:0001525 angiogenesis EPAS1 GO:0001525 angiogenesis ADORA2B GO:0001595 angiotensin_receptor_activity AGTRAP GO:0004945 angiotensin_type_II_receptor_activity AGTRAP GO:0005253 anion_channel_activity CLIC6 GO:0006820 anion_transport SLC17A1 GO:0006820 anion_transport SLCO2A1 GO:0006820 anion_transport CLIC6 GO:0006820 anion_transport PTGER3 GO:0008509 anion_transporter_activity OCA2 GO:0008509 anion_transporter_activity SLC17A1 GO:0008509 anion_transporter_activity SLCO2A1 GO:0009952 anterior/posterior_pattern_formation EMX2 GO:0009952 anterior/posterior_pattern_formation EPHA3 GO:0009718 anthocyanin_biosynthesis