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Home , Archaeal transcription, Corepressor, Eukaryotic transcription, Promoter (genetics), Repressor, Response element

Mechanisms of Eukaryotic

Session 1 INITIATION COMPLEXES TUESDAY 8/27/2013, 7:30 PM P. Cramer # lname Title Talk Length 1 Nogales Visualizing core recognition and transcription preinitiation complex assembly 13 2 Murakami Architecture of an RNA II transcription pre-initiation complex 13 3 Kadonaga The TCT core promoter motif functions with a specialized transcription system 13 4 Werner Progression of archaeal RNA polymerase through the transcription cycle 13 5 Ebright Structural basis of transcription initiation 13 6 Kaplan RNA Polymerase II catalytic activity shapes transcription start site utilization globally in 13 Saccharomyces cerevisiae 7 Levens The interplay of transcription, DNA conformation and DNA topology across the 13 8 Price correlates globally with transcription machinery rather than specific DNA elements 13

Session 2 ACTIVATORS AND CO-ACTIVATORS WEDNESDAY 8/28/2013, 9:00 AM J. Conaway # lname Title Talk Length 9 Workman Myeloid leukemia factor acts in a complex to regulate stability and 13 expression 10 Chiang and partner switch regulate Brd4 gene-specific targeting and pathway selectivity 13

11 Guertin Discrete, estrogen-stimulated H3R26 deimination specifically marks and stabilizes ER binding to 13 enhance 12 Berk Adenovirus e1a reveals a novel function of p300 in transcriptional repression and condensation of 13 higher order structure 13 Roeder Mechanistic studies of the cooperative functions of transcriptional coactivators on chromatin 13 templates 14 Näär Therapeutic targeting of a transcription factor interface in 13 15 Fong Novel role of coactivators in stem cell pluripotency 13 16 Hahn Mechanism and specificity of transcription activation domains 13

Session 3 POSTER SESSION I WEDNESDAY 8/28/2013, 2:00 PM

# lname Title Talk Length 17 Abdus-Saboor Evidence for a cell fate refinement mechanism in olfactory sensory neurons

Page 1 of 13 18 Alpern The TFIID subunit TAF4 is essential for post-natal hepatocyte development by regulating preinitiation complex formation, RNA polymerase II pausing, and promoting HNF4α occupancy of functional sites 19 Ansari Erasing the CTD code—New mechanisms by which Ssu72 regulates Pol II 20 Aristizabal High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8 21 Arnaudo How do complexes recognize the ? A case study 22 Bahat DTIE is a novel core promoter element that directs start site selection in -associated TATA-less 23 Bai Stochastic expression and epigenetic at the yeast HO promoter 24 Bai The function of transcription elongation in hematopoietic stem cell development 25 Banyai Cell cycle dependent transcription control by the CDK8 module of the Mediator complex 26 Bartholomeeusen CDK12 mediated regulation of inducible FOS gene expression includes proper 3' processing

27 Baumgart Establishing promotor-proximal paused RNAPII complexes and CDK9-dependent pause-release in vitro 28 Bayles ELL2 regulates Igh mRNA processing and plasma cell development 29 Bernstein H2A variants in development and disease 30 Biggin System wide analyses have underestimated transcriptional importance in animals 31 Björklund Mediator subunits control developmental programs and specific metabolic pathways 32 Blombach A TFIIEα/C34 hybrid-like transcription factor in 33 Bonasio Interactions between JARID2 and noncoding regulate PRC2 recruitment to chromatin

34 Campos Chaperoning histone H3.1 during DNA replication 35 Carlsten Mediators role in centromeric RNA-processing 36 Cecere Positive regulation of Pol II transcription by CSR-1 RNAi pathway in C. elegans 37 Cevher Reconstitution of functional core human Mediator complex 38 Chaubal Regulation and post-translational modifications of SIN3 isoforms 39 Chavez The prefoldin complex regulates chromatin dynamics during transcription elongation 40 Chen Dynamic chromatin organization during embryonic development 41 Chen Site-specific mapping of the protein interaction network within the RNA polymerase III initiation complex 42 Chen AML1-ETO activates transcription through recruitment of JMJD1C in acute myeloid luekemic cells 43 Chen Using yeast Sen1 to assess the molecular defects of disease in the Senataxin gene that cause motor neuron degeneration

Page 2 of 13 44 Cheng Role of H3K4me1 in regulation of facultative and inducible genes 45 Chiu Exploring the role of the U1-PAS axis in regulating divergent transcription 46 Chymkowitch SUMO positively regulates tDNA expression in Saccharomyces cerevisiae 47 Ciesiolka Proteomic analysis of human chromatin-associated RNA polymerase I and accessory factors in elongation of transcription 48 Copur Genetic analysis of histone PTMs in Drosophila 49 Cruz The role of TFIIH subunits in mitosis and cell differentiation during Drosophila melanogaster development 50 Davis The NEAT1 and MALAT1 non-coding RNAs localize to active chromatin 51 Davis The SCF Fbw7 degrades Med13 and Med13L and regulates Cdk8 association with Mediator 52 Devys Yeast and human SAGA acetyltransferase and deubiquitinase activities shape all the transcribed regions of the genome 53 Dikstein Transcription initiation and elongation from a traffic perspective—Traffic control, traffic jams and accidents 54 Donovan FOXO-dependent transcriptional activation of Hsp70 in response to oxidative stress 55 Dronamraju A cell cycle regulated circuit comprising Spt6, Ctk1 and PAF regulates Pol II CTD phosphorylation and transcription elongation 56 Duttke Accurate transcription of RNA polymerase II promoters by RNA polymerase III in vitro

57 Eckersley-Maslin Random monoallelic gene expression upon ESC differentiation 58 Eichinger Disengaging the Smc3/kleisin interface releases cohesin from Drosophila chromosomes during interphase and mitosis 59 Engel Structure-function analysis of RNA polymerase I transcription 60 Esnault Genomic analysis of the -regulated MRTF transcriptional response 61 Fernandez Interplay between CTD O-GlcNAcylation and dephosphorylation dependent on PP1α and OGT

62 Fisher-Aylor Genome-wide long distance interaction mapping of RNA Pol2 and the myogenin transcription factor by ChIA-PET—Implications for local “transcription factories” 63 Floer Changes in chromatin architecture upon induction of three pro-inflammatory genes in primary mouse 64 Fordyce Hac1, a basic leucine zipper transcription factor, recognizes multiple DNA target sites via distinct conformations 65 Fredsøe The importance of topoisomerases for chromatin regulated genes 66 Friedman Chromatin in action—Dynamic view of histone modifications during yeast stress response 67 Fuda GAGA Factor regulation of promoter-proximal pausing of RNA polymerase II in Drosophila

Page 3 of 13 68 Fujii Identification and characterization of promoter-bound molecules involved in transcriptional regulation by insertional chromatin immunoprecipitation (iChIP) 69 Fukasawa Mediator CDK subunits have roles in regulating developmental genes cooperatively with chromatin regulators during differentiation 70 Gaarenstroom Mechanism of TGF-β/Smad-mediated transcription on chromatin 71 Gadad Annotation and functional characterization of long noncoding RNAs in breast cancer cells 72 Galbraith Role of the Mediator subunit CDK8 in transcription elongation 73 Gao Role of AUTS2 (Autism Susceptibility Candidate 2), as part of a novel Polycomb Repressive Complex 1 (PRC1), in epigenetic regulation of gene transcription and neuronal functions

74 Ghavi-Helm A temporal view of three-dimensional interactions during embryonic development 75 Gibson NAD+ analog-sensitive of PARP-1—A new approach for studying PARylation 76 Gokey The role of transcription factors in regulating Pol II pausing 77 Govind Histone deacetylases and Pol II CTD kinases promote Spt6 recruitment to the coding regions

78 Gray An RNA-Seq snapshot reveals genome-wide, in vivo mRNA dynamics from unperturbed cells at steady-state 79 Greifenberg Brd4 activates P-TEFb for RNA Polymerase II CTD Phosphorylation 80 Gruenberg Position and function of initiation factors in the preinitiation and open complex 81 Guglielmi Gene specific transcriptional mechanisms at the histone revealed by single cell imaging 82 Guha DNA double stranded breaks enhance the transcription of AIRE target genes 83 Gutierrez The yeast HMG Nhp6A/B and Hmo1 influence SWI/SNF action in vitro and in vivo 84 Haldar BET bromodomains mediate transcriptional pause release in heart failure 85 Hamidian Transcriptional regulation of HIF2A through IGFII mediated PI 3-kinase signalling in neuroblastoma 86 Han Molecular architecture of SAGA revealed by chemical crosslinking and mass spectrometry 87 He Structural visualization of key steps in human transcription initiation 88 Henriques Stable pausing by RNA polymerase II provides a platform for integrating regulatory signals 89 Hermand Signalling through the RNA polymerase II CTD induces gametogenesis by gene-specific 90 Herrera-Solorio Processing the amino terminus of histone H3 of Plasmodium falciparum, a new epigenetic mechanism 91 Herzel Analysis of nascent RNA processing in S. pombe by deep sequencing

Page 4 of 13 92 Howe Conformation of the histone H3 tail at proline 16 is influenced by residues at position 14 and regulates both and partitioning of gene expression during the yeast metabolic cycle

93 Hu Mll2/COMPASS is required for H3K4 trimethylation at bivalent promoters in embryonic stem cells

94 Huang The role of DDX5 and its associated non-coding RNAs in promoting RORγt dependent T-helper 17 cell differentiation 95 Hübner The role of the H3K27 demethylase JMJD3 in transcriptional induction 96 Hui Identification of immediate early transcription factors (IETFs) by synthetic tandem repeat promoter (STAR-PROM) screening 97 Hung Differential utilization of TATA box-binding protein (TBP) and TBP-related factor 1 (TRF1) at different classes of RNA polymerase III promoters 98 Hunter Rtr1 is an atypical RNA Polymerase II CTD phosphatase 99 Ito Physical interaction between PPARγ2 and Mediator subunit MED1 is crucial for induced adipocyte hypertrophy 100 Iwafuchi-Doi Hypersensitive mark functional regulatory sequences in mammalian tissues 101 Jasnovidova Toward understanding how C-terminal domain (CTD) of RNAPII accommodates multiple processing factors 102 Jennings Mechanisms of Groucho-mediated repression 103 Jimenez-Badillo The bidirectional promoter of CatSper1 regulates the expression of a new transcript 104 Jin A high-resolution map of signaling-dependent, dynamic chromatin interactome in human cells

105 Joo Proteomics of RNA polymerase II initiation and elongation complexes 106 Juven-Gershon Core promoter composition plays a critical function in the regulation of gene expression of Drosophila dorsal target genes 107 Kabzinski Structural basis for the dual role of Nrd1 in transcription termination and RNA processing 108 Kakar Structural insights into the bacterial homolog of Swi1/Snf2 proteins 109 Kaneko Ezh2 binds to nascent transcripts in mouse ES cells 110 Kasper Relationship between CBP recruitment to promoters and enhancers and CBP/p300 dependent gene expression 111 Kauzlaric The known KAP1 can function as a transcriptional 112 Kelly Identification of a new class of small RNAs bound to Ago2 derived from protein coding gene promoters 113 Kelso Cdk7 controls cell cycle progression in a permissive manner and is critical for formation of paused complexes and transcription elongation 114 Khoo Mapping the protein interaction network for Brf1 in the RNA Polymerase III initiation complex

115 Kim The Nrd1 CID contributes to the choice of RNA polymerase II termination pathway and couples to RNA processing by the nuclear exosome

Page 5 of 13 116 Kim HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade 117 Knutson Chemical crosslinking and mass spectrometry of S. cerevisiae RNA polymerase I core factor—A model for core factor assembly and Pol I PIC architecture 118 Kok Genome-wide characterization of transcriptional repression mechanisms mediated by Hairy in the Drosophila embryo 119 Kong Mechanism of Mef2c-dependent transcription in lymphoid-specific hematopoietic differentiation

120 Krivega Role of Ldb1 in the transition from chromatin looping to transcription activation 121 Krukenberg Differential activity points to a transcriptional role for PARP1 that is more prevalent in some breast cancer cell lines 122 Kutejova Shh controlled neural tube specific 123 Kuznetsova Regulation of RNA Polymerase II activity by human RPAP2

Session 4 SIGNALING AND REGULATORY COMPLEXES WEDNESDAY 8/28/2013, 7:30 PM K. Arndt # lname Title Talk Length 124 Cairns Regulatory architecture of chromatin remodeling ATPases, and roles of actin-related proteins 13

125 Conaway Multiple modes of egulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin 13 remodeling complex 126 Verrijzer Chromatin dynamics in the male germ line 13 127 Willis Signaling repression of transcription by RNA polymerase III 13 128 Shilatifard Enhancer marking and regulation during development and in disease 13 129 Grishok Negative regulation of transcriptional elongation by the ZFP-1(AF10)/DOT-1 complex in C. 13 elegans 130 Kraus Control of cellular signaling and differentiation programs by PARP-1, a multifunctional regulator 13 of chromatin and transcription 131 Jones A novel α-catenin:APC complex regulates Wnt/β-catenin transcription 13

Session 5 ELONGATION, PAUSING AND TERMINATION THURSDAY 8/29/2013, 9:00 AM W. Bickmore # lname Title Talk Length 132 Levine The promoter controls the timing of gene expression in the Drosophila embryo 13 133 Zhou Core P-TEFb has a third subunit that facilitates HIV Tat disruption of 7SK snRNP and formation 13 of the Tat-SEC complex for full activation of viral transcription 134 D'Orso The PPM1G phosphatase controls transcription elongation by RNA polymerase II through the P- 13 TEFb kinase

Page 6 of 13 135 Svejstrup RECQL5 controls transcript elongation and suppresses transcription-associated genome 13 instability 136 Benkirane Integrator complex—It’s not just about small nuclear RNA 13 137 Skaar The NABP/INTS3 complexes regulate the termination of transcription 13 138 Bunch TRIM28 regulates RNA polymerase II promoter proximal pausing and entry into processive 13 elongation 139 Lis Selection and massive parallel characterization of RNA aptamers and their application in 13 dissecting transcription mechanisms Session 6 POSTER SESSION II THURSDAY 8/29/2013, 2:00 PM

# lname Title Talk Length 140 Baugh Pol II docking and pausing at growth and stress genes in C. elegans 141 Laitem CTCF—Regulator of elongation checkpoint 142 Lama Coligo transcription by RNA polymerase III—Chemically synthesized vectors for producing small RNA in vitro and in human cells 143 Lauberth TAF3 through direct interactions with H3K4me3 coordinates preinitiation complex assembly to regulate selective p53 target gene expression 144 Le May Roles of NER factors in the regulation of gene expression—Involvement of XPC in modifications 145 Lehming Histone H4Y98 is required for correct nucleosome distribution between promoter and open reading frame of the HIS3 gene 146 Lewis O-GlcNAcylated RNA polymerase II is found on promoters in vitro and in vivo and functions as promoter-localized nutrient sensor 147 Li Cdk12 is an RNA polymerase II kinase that is specifically required for the activation of stress responses 148 Liang The putative CTD kinases CDK12 and CDK13 have related yet distinct transcriptional outputs

149 Lin Selective inhibition of tumor by disruption of super-enhancers 150 Lisica Single-molecule studies of RNA polymerase I elongation 151 Liu Roles of the general transcription factor TFIIB in transcription initiation 152 Lu Functional characterization of a human MLL2 complex and a novel MLL complexes associated protein Akap95 153 Lu NELF-A and NELF-B modulate properties of receptor-regulated gene induction via two steps 154 Luo PARP-1 modulates adipogenesis by regulating the expression and activity of adipogenic transcription factors 155 Luse The RNA polymerase II associated protein Gdown1 can enter the preinitiation complex and accompany pol II through initiation and transcript elongation

Page 7 of 13 156 Ma A knowledge base for community curation of human long non-coding RNAs 157 Malecova Tyrosine phosphorylation by DNA damage-activated ABL kinase promotes p300 recruitment and hyperacetylation at promoters of apoptotic genes 158 Mannervik Functions of the CBP co-activator at paused promoters and in control of early Drosophila embryo development 159 Marr The magnitude of the transcriptional response to heavy metal is dictated by a complex interplay of between TFIID and Mediator 160 Martianov Chromatin immunoprecipitation of TFIID sub-units followed by deep sequencing reveals the recruitment of TFIID sub-complexes missing one or more TAFs to some promoters 161 Martinez-Rucobo Architecture of the RNA polymerase-Spt4/5 complex and basis of universal transcription 162 Mattiroli Mechanisms of histone H2A ubiquitination 163 Maureira Characterization of CREB and C/EBPβ binding sites in human RIC-8B gene promoter 164 McAlear Mechanisms of adjacent gene co-regulation in S. cerevisiae 165 McCready Epigenetic regulation of crabp1 during mammary gland development 166 McNamara The PPM1G phosphatase controls transcription elongation by RNA polymerase II 167 Moreno-Campos Transcriptional analysis of 5S ribosomal RNA genes of Leishmania major 168 Murawska Functional and structural dissection of the roles of Spt6 during transcription elongation 169 Nakadai Molecular mechanism of transcription activation by orphan ERRα and PGC-1α 170 Nechaev Pol II pausing remains on human SNAIL gene during its activation 171 Nemet The YEATS domain protein TAF14 exhibits complex regulatory properties across the genome

172 Ni RPRD1A and RPRD1B serve as RNA polymerase II CTD scaffolds to recruit RPAP2 for serine 5 dephosphorylation 173 Nishi Transcriptional repressor-mediated cell fate specification programs in the ventral neural tube

174 Ohkuma Association of the winged helix motif of TFIIEα with either TFIIEβ or TFIIB distinguishes its function between transcription initiation and the transition from initiation to elongation 175 Ohtsu Characterization of transcriptional reactivation during M/G1 transition in mammalian cells 176 Onoguchi A long noncoding RNA derived from an enhancer region regulates Neurogenin1 gene expression

177 Oviedo Sox transcription factors regulate Catsper1 gene promoter expression 178 Padilla-Mejía Selenocysteine tRNA gene in Leishmania major—Is it transcribed by RNA polymerase II?

179 Pani eEF1A1 couples transcription to during heat shock response 180 Park Real-time observation of activity-dependent transcription in live neurons and brain tissues

Page 8 of 13 181 Park Unraveling the mechanism of RNA polymerase II termination by Rat1 182 Pearson Regulation of Pol II transcription termination via interactions between termination factors and the body of Pol II 183 Pelechano Regulation of transcriptional heterogeneity by chromatin and transcription machinery 184 Pengelly Functional analysis of histone residues in Polycomb repression 185 Pierre-Jerome Reconstruction of -induced transcription in Saccharomyces cerevisiae 186 Plank Identification of factors involved in human hemoglobin switching 187 Polletti Reorganization of the epigenome during sustained stimulation 188 Pufall The potency of glucocorticoid receptor ligands is related to the stability of occupancy, but not affinity or selectivity 189 Puri Direct conversion of hESCs into skeletal muscles requires formation of BAF60C-based SWI/SNF complex 190 Qiu Identification of a 16-amino-acid region in Drosophila DSIF that is important for promoter proximal pausing 191 Ranish Molecular architecture of TFIIH 192 Ravichandran Eaf3 stimulates NuA4 interaction with methylated H3K36 193 Ray Identification of Combgap as a novel DNA binding protein necessary for epigenetic silencing by Polycomb group proteins 194 Reja Understanding the organization of regulatory complexes at ribosomal gene promoters using ChIP-exo. 195 Resto CTD O-GlcNAcylation of RNA polymerase II acts as a sensor of the nutrient state of the cell

196 Rezsohazy Substituting non-canonical residues of the mouse Hoxa1 homeodomain generates a functionally dominant protein in vivo—Insights into the functional specificity of a Hox transcription factor

197 Rodriguez-Molina Unexpected gene-class specific differences in Nrd1 recruitment 198 Rojas-Sánchez Analysis of the U2 snRNA gene promoter in the protozoan parasite Leishmania major

199 Romero-Meza Molecular characterization of Maf1, putative negative regulator of RNA Polymerase III transcription in Trypanosoma brucei 200 Ronsmans Implication of the SAGA complex in the regulation of nitrogen -sensitive gene transcription 201 Rosonina Threonine-4 of the yeast RNAP II CTD couples transcription with H2A.Z-mediated chromatin remodeling 202 Rossi An In vitro genome-wide assay to study transcription factor binding 203 Saha Analyzing the genomic recruitment of SIN3 isoforms 204 Sainsbury Structure and function of the initially transcribing RNA polymerase II-TFIIB complex 205 Saldana-Meyer CTCF regulates the p53 gene through direct interaction with its natural antisense transcript

Page 9 of 13 206 Schneider Divergent contributions of conserved active site residues to transcription by eukaryotic RNA I and II 207 Shi BAF complex cooperates with BRD4 at distal enhancer elements to support cancer maintenance

208 Shimada NAP1 facilitates transcriptional activation from a higher-order (30 nm) chromatin via through linker histone removal 209 Singer MHC class I core promoter elements are not essential for transcription in vivo 210 Smallwood Role of H3K4me1 in enhancer function 211 Smith The little elongation complex functions at initiation and elongation phases of snRNA gene transcription 212 Smollett Whole genome occupancy profiling of the machinery 213 Soares Interplay between degradation and stabilization of ySet1 regulates H3K4 214 Son Nucleosome binding activity of Jarid2, which is inherited to Ezh1, is required for PRC2-Ezh2 regulation 215 Soshnikova Mammalian PBAF complexes containing different isoforms of PHF10 signature subunit are functionally distinct 216 Soutourina Mediator links transcription and DNA repair by facilitating Rad2/XPG recruitment 217 Spain RSC recruitment to coding regions promotes elongation at a subset of low to moderately transcribed genes 218 Stanek Epigenetic modifier USP22 mediates an activator-driven transcriptional response 219 Stavreva Chromatin dynamics and gene regulation in response to glucocorticoid signaling 220 Stumph The 4.5 Myb repeats of SNAP190 interact differently with the DNA of U1 and U6 snRNA gene promoters 221 Surface H2A.Z mono-ubiquitylation regulates heterochromatin formation during lineage commitment

222 Suzuki Functional analysis of H3K36 methyltransferase Set2 for heterochromatic silencing in Schizosaccharomyces pombe 223 Takahashi Human Mediator subunit Med26 regulates the transcription of small nuclear RNA genes through the recruitment of little elongation complex 224 Takahata Heterochromatic silencing defect in FACT is concomitant with impaired H2A/H2B reorganization 225 Tang SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53 226 Tee Crosstalks between signaling pathways and epigenetic regulators promote lineage competence

227 VanDemark The structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin 228 Veenstra Chromatin state transitions and epigenetic constraints during early vertebrate development 229 Venkatesh Deacetylase independent role of H3K36 methylation in suppressing non-coding transcription

Page 10 of 13 230 Venters of human transcription initiation complexes 231 Vinayachandran Genome-wide structural integration of SWR-C and INO80 chromatin remodelers at +1 nucleosomes 232 Wal In vitro approach to study the determinants of nucleosome positioning in Saccharomyces cerevisiae 233 Wamstad Dissecting epigenetic regulatory networks during heart development 234 Wang The “dark matter” of RNA polymerase II transcriptional fidelity 235 Wang Liver Med23 ablation improves glucose and lipid metabolism and prevents diet-induced obesity

236 Wang Mechanism of action of the MLL3/4 H3K4 methyltransferase complex in countering H3K27me3- and PRC1/2-mediated gene repression 237 Weinzierl High-throughput mutagenesis and molecular dynamics studies of RNA polymerase 238 Xu Acetylation of the amino terminus of Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain 239 Yamaguchi DSIF and NELF interact with the Integrator complex and participate in 3’-end processing and termination of U1 snRNA 240 Yang Role of the homeodomain transcription factor, Otx2, in early embryonic stem cell differentiation

241 Yao Mediator MED23 links an epigenetic modification to the transcription activation 242 Yokoyama Regulation of cell cycle and ROS homeostasis by Jun dimerization 2 243 Yuan H2A ubiquitination inhibits the enzymatic activity of H3K36 methyltransferases 244 Zaborowska Gene type-specific control of pol II transcription elongation 245 Zhang Structural insights on the XPC DNA repair complex, a stem-cell-specific transcriptional co- activator 246 Zhang Visualization of human RNA polymerase II transcription one molecule at a time 247 Zhong Sirt6, a protein deacetylase, regulates transcription elongation

Session 7 THE CTD AND POST-INITIATION EVENTS THURSDAY 8/29/2013, 7:30 PM R. Young # lname Title Talk Length 248 Manley New functions for the RNA polymerase II CTD 13 249 Buratowski The Rpb1 CTD can function on other RNA polymerase II subunits 13 250 Geyer The structure and substrate specificity of human Cdk12/Cyclin K 13 251 Greenblatt Symmetric arginine dimethylation of the RNA polymerase II CTD mediates regulation of 13 transcription termination by SMN and SETX 252 Neugebauer The earliest transcribed zygotic genes are short, newly evolved and different across species 13

Page 11 of 13 253 Cowling Cell cycle-dependent activation of the mRNA cap methyltransferase 13 254 Brow Biochemical, genetic and genomic analysis of Sen1 helicase function in Pol II transcription 13 termination 255 Hampsey Gene loops facilitate mRNA export in yeast 13

Session 8 TRANSCRIPTIONALLY ACTIVE CHROMATIN FRIDAY 8/30/2013, 9:00 AM A. Shilatifard # lname Title Talk Length 256 Luger Dissecting histone chaperone function 13 257 Robert Establishing the H2A.Z genomic landscape—The unexpected role of histone chaperones 13 258 Mellor Antisense transcription confers a noisy, bursting expression profile via dynamic chromatin 13 259 Arndt Analysis of the mechanisms by which the Paf1 complex regulates histone modifications and 13 associates with RNA polymerase II 260 Ladurner Structural basis of histone H2A-H2B recognition by the essential chaperone FACT 13 261 Li Marking and reading histone H3K36 methylation 13 262 Chery An evolutionarily conserved zinc finger protein promotes X-specific targeting of Drosophila 13 dosage compensation 263 Gross Heterochromatic gene activation bypasses epigenetic landmarks of transcription 13

Session 9 REPRESSIVE CHROMATIN FRIDAY 8/30/2013, 2:00 PM K. Luger # lname Title Talk Length 264 Narlikar Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of 13 heterochromatin spread 265 Moazed Mechanism of RNAi-mediated heterochromatin assembly 13 266 Johnson Heterochromatic by activator interference and a transcription elongation barrier 13

267 Carey An Ies6-dependent nucleosomal locking mechanism enforces transcriptional silencing by Sir 13 complex 268 Kingston Genome- and chromosome-wide roles for long non-coding RNAs 13 269 Kurdistani Evolutionary contribution of histones to genome condensation 13 270 Reinberg Polycomb complexes and the brain 13 271 Bickmore Transcription and —Chicken and egg 13

Page 12 of 13 Session 10 GENOMICS AND SYSTEMS BIOLOGICAL APPROACHES SATURDAY 8/31/2013, 9:00 AM B. Cairns # lname Title Talk Length

272 Pugh Genome-wide organization of chromatin and the transcription machinery at very high resolution 13

273 Weber Nucleosomes are context-specific barriers to transcription that are modulated by H2A.Z 13 274 Young Roles of super-enhancers in control of normal and cancer cell states 13 275 Ren The long-range chromatin interaction landscape of hESC and hESC-derived lineages 13 276 Cramer Structure-function analysis of genome transcription 13 277 Auble Measuring locus-specific chromatin interaction dynamics on the second time scale 13 278 van Leeuwen Discovering chromatin regulators by barcode screens 13 279 Struhl The transition between transcriptional initiation and elongation in yeast 13

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