ANNUAL REPORT | FY2019

TOMORROW IS HERE OUR PURPOSE: Bringing together the University community and local and regional ecosystems, we're making a better world by moving inventions stemming from UArizona research into the marketplace where they can create lasting social and economic impact.

UNIVERSITY OF INTEGRITY: ADAPTATION: ARIZONA CORE Be honest, respectful, Be open-minded and VALUES and just. eager for what’s next. 3 5 IT'S HAPPENING HERE WELCOME

EXPLORATION: INCLUSION: Be insatiably curious. Harness the power of diversity. 7 9 DETERMINATION: COMPASSION: BY THE NUMBERS INVENTIONS Bear Down. Choose to care.

15 17 MAKING IT HAPPEN ASSET DEVELOPMENT

19 21 VENTURE DEVELOPMENT A TEAM TO MAKE IT HAPPEN IT’S HAPPENING HERE.

At Tech Launch Arizona we have a motto that drives every team member every day: #MakeItHappen. We pride ourselves on carrying out our responsibilities with integrity – maintaining transparency and honesty in all our interactions. We see the inclusion of a diverse and collaborative team as an essential ingredient in creating a workplace where everyone can thrive. We are constantly evaluating our methods and processes to adapt to an ever-changing world, exploring more effective and creative ways to gain efficiencies, reach our goals and address challenges with open minds. We are determined to be the best at what we do, enhancing the impact of Arizona research and intellectual property, and will overcome any and all obstacles in our path. Through it all, we keep compassion in the forefront, working with internal and external customers to understand their goals and concerns, and arrive at mutually advantageous solutions.

ROBERT C. ROBBINS, PRESIDENT OF THE UNIVERSITY

I am proud that Tech Launch Arizona our impact here in Tucson, in Arizona, this year are just a few examples is a vital part of our vision for the and around the world. Building on of the way University innovations University of Arizona, and for our our strengths, we are leading the spur economic development and potential as a world leader in the world to address grand challenges at benefit the people in our state. "UAVenture Capital has made 13 investments in UArizona technology Fourth Industrial Revolution. As a the edges of human endeavor and Tech Launch Arizona is the mechanism public land-grant, AAU university, capability, with focal points like space startups. TLA has been a huge resource to us, not only in deal to translate the groundbreaking we are uniquely well-positioned sciences and technology; creating research happening here at Arizona sourcing but in the preparation of faculty inventors to interact to address grand challenges healthier communities; the aging into products, services, and with venture capital. The strength of TLA patent protection has faced by people all over the brain; data, network, and computer companies that reach people all world, and TLA’s success this year sciences; humanics, the intersection of helped create unparalleled technology in a variety of fields." over the world. It is a major source demonstrates that our solutions- technology and human engagement; for the University’s impact, and I —Fletcher McCusker, oriented culture and strategic and creating a sustainable future am grateful to Doug Hockstad for CEO, UAVenture Capital investments are producing results. Earth. The new inventions in our his leadership as we work toward commercialization pipeline and Our strategy emphasizes areas where creating a bold and bright future. companies launched through TLA the University of Arizona can maximize

3 4 WELCOME

DOUGLAS HOCKSTAD DR. ELIZABETH CANTWELL ASSISTANT VICE PRESIDENT, SR. VICE PRESIDENT OF TECH LAUNCH ARIZONA RESEARCH & INNOVATION

I’ll begin our annual report with a At the same time, these words are It has been a transitional year Cantwell, the incoming Senior Vice As a new arrival on the UArizona ensuring these assets are protected little explanation about the theme, a reminder that we have a unique for us. We have had a number of President of Research and Innovation, research scene, I’m especially excited and, when feasible, moved into “Tomorrow is here.” There’s so opportunity—and responsibility— employees leave us to retire or who oversees our office, as well to be working with Tech Launch commercial and social applications much encapsulated in these three to ensure that these inventions, seek new opportunities, and at the as Research, Tech Parks Arizona Arizona, where our brightest minds where they can do the greatest good. words, it’s worth peeling back the these steps toward a better same time, have been fortunate to and Arizona Forge. Being a part of are putting their best breakthroughs This vitally important work is in onion a bit to give us context. tomorrow, get out into the world. hire new talent with an impressive this pantheon, I am excited about to work for a better future. line with the University of Arizona’s library of experiences to bring to the incredible potential for growth mission as a land grant university. In one sense, the phrase refers to this With this theme as our touchstone, we Every day, our faculty, researchers and the table. Through all the change, and impact in the coming years. place, the University of Arizona. In are continuing to focus our programs graduate students make discoveries I’m looking forward to learning about we have continued our steady this place at this time, people across on delivering on our mission and and invent new technologies. In and sharing many thrilling discoveries rise amongst our peers, and kept the UArizona ecosystem are working growing the impact of the inventive FY2019 alone, UArizona inventors as part of the UArizona research our focus on sustainable levels of to solve problems and develop minds of the UA, from increasing reported 284 innovative ideas, from community. And I’m so proud to output and growth, and high-quality solutions that can make a better the number of inventions flowing 3D printed contact lenses to new support the dedicated people at TLA outcomes for all of our clients. world, improving and even saving into the marketplace to creating tech for cleaning up ocean-polluting who help breakthrough ideas find lives. We are honored to be working more opportunities for startups Looking ahead, we will continue plastics. Collectively, these innovations real and lasting impact, launching with these inventors, as well as our to helping more teams pursue to innovate and develop new make up a sweeping portfolio of tomorrow's solutions from today's extended network of experts, to bring their entrepreneurial dreams. strategies for impact. In FY2020, intellectual property. TLA takes on academic classrooms and labs. these technologies out into the world. we are excited to welcome Betsy the responsibility and privilege of

5 6 TECHNOLOGY COMMERCIALIZATION LIFECYCLE 2019

BY THE NUMBERS 11 STARTUPS FORMED

16 15 14 12 Every year, UArizona research yields inventions with 11 11 commercial potential. TLA shepherds ideas from the lab to the marketplace – from evaluating and protecting discoveries to commercializing 3 RE SEAR the inventions through new and SE & D CH U TH EVELO & LIC OW PM B GR EN existing companies. PU IC T OM 2013 2014 2015 2016 2017 2018 2019 N O EC

IN V E N T T T N I O C E N U M D P

O O L R E P

V

E $733M TECHNOLOGY D RESEARCH EXPENDITURES (in $ Millions)

FY2019 733 COMMERCIALIZATION E

V 687 A

L 622

CYCLE U 629 606 604 A 588

L

I T

C I

E O N N S IN G

N IO M CT AR TE KE RO TING IP P

2013 2014 2015 2016 2017 2018 2019

$5.9M 96 56 341 284 OF ROYALTIES & OTHER INCOME LICENSES & OPTIONS PATENTS ISSUED PATENTS FILED INVENTION DISCLOSURES (in $ millions) 284 5.9 349 341 275 equity + other 112 334 105 261 royalties 4.1 250 3.9 95 96 278 83 213 188 2.3 1.2 2.1 72 2.7 200 144 167 2.0 48 145

1.1 0.9 1.6 2.9 3.8

27 24 35 36 47 36 56

2013 2014 2015 2016 2017 2018 2019 2013 2014 2015 2016 2017 2018 2019 2013 2014 2015 2016 2017 2018 2019 2013 2014 2015 2016 2017 2018 2019

7 8 CREATION OR OPTIMIZATION OF NOC 284 INVENTIONS ROUTINGTHAT HAVE PROTOCOLS THE & POTENTIAL TO CHANGE THE WORLD In FY2019, UArizona ON-PROCESSOR DESIGN inventors brought 3D PRINTING USING forward these 284 EXTRATERRESTRIAL innovative ideas for POLYMERS -SILVER a better world. SULFIDE REFERENCE ELECTRODE ANTIBODY- DRUG-GRAFTED IMMUNE CELLS AGENTS, METHODS, & COMPOSITIONS FOR TREATING & PREVENTING ALZHEIMER’S DISEASE PROGRAMMABLE PLANTS GLYCOSYLATED OXYTOCIN 9 ANALOGUES FOR NON- 10 OPIOID PAIN RELIEF 284 INVENTIONS THAT HAVE THE POTENTIAL TO CHANGE THE WORLD

SPACE EXPLORATION & OPTICAL SOLUTIONS IMPROVING HEALTH NATIONAL DEFENSE & SECURITY SYSTEMS

– A Fast Compression Algorithm – Heterogeneously Integrated Saturable – Open Loop Pointing Technique for – 3D Printed Lens for Imaging – CSFR Inhibitor in Treatment of – Leukocyte RNA Expression: A – Novel 5-Fluorouracil Prodrug for – Ozone in Combination with – Targeting Mitochondrial Genetic – 3D Printing Using Tholins or Other – Inexpensive and Processable – Sea Radar Camouflage for Images and Video Capable Absorber in a Photonic Integrated Orbital Laser Communications in Falloposcope Tinnitus, Hearing Loss, Hyperacusis, Novel Neurosurgical Genomics Colorectal Cancer Therapy Essential Oil Microemulsions as Variances as a Precision Medicine Extraterrestrial Polymers Polymer Magneto-Optic – System and Method for Aligning of Real-Time Speed Circuit: Methods and Designs – Optical Design Methods for Head- – A "Mechanical Conditioning" Central Auditory Processing Deficit Technique for Predicting Seizure- – Novel Compounds that Selectively Antimicrobial Sanitizers for Produce Opportunity for Alzheimer’s – Autonomous Soft Robotic System Nanoparticle Composites for Diverse Human-Computer – A Low-Cost Agricultural Solar – High-Resolution and High-Throughput Mounted 3D Light Field Displays Multi-Gene Score for Prediction – Design and Application of New Free Outcome following Stereotactic Inhibit HSP70 Isoforms for – Patient-Derived Established Pancreatic Disease Therapies Faraday Rotation: Plastic Garnet Interaction Data to Specific Laser Amygdalohippocampotomy – Chalcogenide Hybrid Inorganic/ Optical Isolators and Sensors Bioreactor Module Additive Manufacturing – Optical Gyroscope with Gain and Intervention of Breast Split-Luciferase Enzymes the Treatment of Cancer Neuroendocrine Cell Culture System – Targeting TDP-43 for Parkinson's Organic Polymers (CHIPs) Using Fields on an Online Form – Aberration Correction in Volume – High-Speed Confocal Medium and Circulating Light Cancer Bone Metastasis – Development of Aptamers Neutralizing – Lipid Biomarkers for Cancer – Novel Conditional Knockout – Peer Support Software to Disease Therapy Cyclic Olefinic Comonomers – Making the Heat Generated – System and Method for Generating Holographic Optical Elements – A CEACAM6 Immunomodulatory Antibodies for Demyelinating Diseases Screening and Monitoring Model Of ER-Alpha in Rats Support First Responders – The FAMCON For Prediabetes Program in Hypersonic Flight Being a Risk and Intent Score Based on – Holographic Elements for – Optomechanical Inertial Reference – Energy Efficient Switching in Critically Utilized Using Spatial Light Modulator Augmented Reality Headware For Atom Interferometers Antibody Targets Pancreatic Cancer – Diagnostic Analyte to Enrich LINE-1 and – Liquid Biopsy for Cancer Using – Novel Conditional Knockout – Perfusion System for – The Mobile Vertical Farm (Go- Magnetic Tunnel Junctions with Navigation and Form Completion Computer Generated Holograms DNA Methylation Markers – Optical Device Elements, Lenses, Behaviors Through Diverse Human- – Hybrid 3D Optics Printing – Oral and Oropharyngeal Cancer – A Molecular Diagnostic Tool for Detect LINE-1 Driven Oncologic Disease Model Of ER-Beta in Rats Automatic Cell Culture Vertical Farm) for Automation of an Antiferromagnetic Barrier – Amplified Deformable Mirror (ADM) Detecting Clostridium Difficile – Measuring Edema and Vertical Farming Operations Windows via of Computer Interaction Data – Hybrid Pyramid-Shack- Screening System and Methods of Use – Diagnostic for predicting – Novel Conditional Knockout Models of – Polyethyleneglycol Coated – Low RCS Meta-Material Chalcogenide Hybrid Inorganic/ – Aperture Designs to Minimize Infection, Carriage and Outbreaks Women "At Risk" for Poor Body Composition in Heart ER-Alpha and ER-Beta in Rat Brains Shells for NanoSPA – Tools and Techniques to Identify for Radar Illuminator – Trackable Reasoning and Analysis for Hartmann Wavefront Sensor – Phase Unwrapping by Neural Network Failure Using EchoMRI Organic Polymers (CHIPs) Crowdsourcing and Evaluation (TRACE) Diffraction Noise – A New Method for Preventing Gynecologic Health Outcomes – Novel Forebrain Neuron – Re-Formulation and Local Drug Antigen-Specific T Cells – Induction Heating for Forming – Photonic Quantum Computing Using and/or Treating Asthma and – Method for Improving Homology- – ASLM Multi-Display High-Precision Panels Entangled Squeezed State Clusters – DOJO Specific CreERT2 Rat Model Delivery Methods of TNF-Alpha – Transcriptional Regulatory Related Respiratory Conditions Directed Repair Using the Adapted- Inhibitors to Treat Tinnitus Network Evolution Simulator – Assembly of Flexible Optical – Integrated Frequency Locked Optical – Polaritonic Phase Transition – Draft Genome Assembly of the Type II CRISPR-Cas System – Novel Knockout Model of ER- Waveguides and Photonic Chips for – A Peptide Approach to Block Entomopathogenic Bacterium Alpha in Rat Neurons – Repurposed FDA-Approved Drugs – Ultrasound-Guided Percutaneous OTHER Whispering Evanescent Resonator Computing Architecture eNOS Phosphorylation at T495 – Methods and Apparatus Suitable Optical Interconnection Packaging (FLOWER) Based on Raspberry Pi Photorhabdus Luminescens – Novel Knockout Model of ER- as an Optical Biopsy Stain Panel Nephrostomy Model – Polarization State Scrambler – A Series of Novel Autophagy Inhibitors Subsp. Sonorensis for Interrogating Biological – Bifacial Spectrum Splitting – Integrated Lander Chassis for CubeSats Using Birefringent Phase Mask Systems: Tumor-on-Chip Beta in Rat Neurons – Repurposing of an FDA Approved – Universal Chimeric Antigen Receptors – 2018 Congressional District 3 Debate – Entangled Quantum Sensor – Probabilistically Coded Photovoltaic Module – Affinity Peptide Conjugated – Essential Oil Microemulsions and Plant Drug (Telaprevir) for Treatment for T-cell Cancer Therapy Network Enhanced by Practical Modulation Formats for 5G – Kinematically Engaged Yoke System – Polishing Interface Coating – Methods and Compounds to Treat and – Novel Liquid Formulations of – 3-D Printing of Structures Using – Blown Lens with Antioxidant for Protection Extracts to Prevent Biofilm Formation Sirolimus for Localized Delivery in of Enterovirus D68 – Variable Solvent Polarity Laser Patterning of Precondensed, Quantum Repeaters Mobile Fronthaul Networks – Laser Beam for External Position Technology of Proteins from Oxidation Prevent Macular Degeneration Through Array and Method – Five Module Chimeric Antigen Restoration of Daily Rhythm of Specific the Prevention of Graft Rejection – Size-Conforming PET Scanner Chromatography Liquid Silica and Organically – Entanglement-Enhanced – Residency Interview Tracker Control and Traffic Management – Polychromatic Rayleigh – Agents, Compositions and Receptors (5M CARs) Modified Silica Polymers Machine Learning – Cell Collection Device for of On-Orbit Satellites Laser Guide Star Retinal Pigment Epithelium Function – Novel Peptidic Inhibitors of – Smart Box for Health Logistics – Variable Stationary Phase – Resident Evaluation System Biological Analysis Methods for Treating and – Flame Retardant Additives Focal Adhesion Kinase (FAK) Chromatography – A Method for Unsupervised Change – Error Reconciliation Over Application (RES App) – Low-Tension Tether System to – Pseudo-Nulling Mach- Preventing Alzheimer’s Disease – Methods for Building a Self-Contained – SP-A Peptide Mimetics in the Treatment – Center for Astronomical from Chalcogenide Hybrid Responsive Biological System Non-Catalytic Function of Inflammatory Lung Diseases – Vascular Plug Detection Using Deep Learning Covert Channel – Route Computing for Destination- Constrain Satellite Clusters and Permit Zehnder Metrology – An Efficient and Improved Inorganic/Organic Polymers Adaptive Optics' Adaptive High Bandwidth Communications – Methods, Compounds, and – Novel Treatment for Nonalcoholic – Sucrose-Derived Scaffold for Gd – Virtual Patient Assistant (VPA) – Arizona Illustrated Episode – FPGA-Based Rate-Adaptive Oriented Navigation Secondary Controller (CASC) – Quantitative Large Chemical Conversion of the Natural – Focal Adhesion Kinase (FAK) as a Fatty Liver Disease #107643: Terrol Dew Johnson Spatially-Coupled LDPC Codes – Material Shape Change Using LIRIC Area Binding Sensor Product Physachenolide D (LG- Compositions for the Treatment MRI Contrast Agent and Method for – Virtual Reality Simulation for – Run-Time Reconfigurable Adaptive – Chip-to-Chip Optical Interconnection Prognostic Immunohistochemical of Neurodegenerative Diseases – Nudel Serine Protease as a Target Use in Colon Cancer Screening – Arizona Illustrated: Stealing for Optical Communications LDPC Coding for Optical and – MEMS-Based Hybrid Beam for Detecting 01) to Its Analogue LG-134 with Marker in Early Stage Cancer Airway Management Between Polymer Waveguides and Biomarkers Potent Anticancer Activity – Modeling Pontocerebellar for Mosquito Vector Control – Superior Infiltration Woman-Ochre – General Recipe for Designing Quantum Wireless Communications Ion-Exchanged Glass Waveguides Steering for LIDAR – Fragment-Based Inhibitors of the Focal – Wireless Battery Free Long- Optimum Receiver Architectures – Saturable Absorbing – An Implantable Miniaturized and Hypoplasia Type 1B (PCH1B) Using – Nutraceutical Formula for Alzheimer's Bioreactor for Scaffolds Range Wearable Recording – Arizona Public Media News – Scientific Discovery as Link Prediction Using High Refractive Index Couplers – Method for the Efficient Generation Adhesion Targeting (FAT) Domain a Chemical Biology Approach and Other Neurodegenerative Diseases Department Photo Using Machine Learning in Influence and Citation Graphs of High Order Hermite Gaussian Fiber for Mass Soft Wireless Sensor to Monitor of Focal Adhesion Kinase (FAK) Platform For Digital Acquisition – Close-Range PET Production of Robust Tissue and Bone Deformation – Modulation of Transient Receptor of Chronic Biological Signals – Arizona's Dust Bowl: Lessons Lost – Hardware Platform Enabling the – Scientific Keyboard Layout (HG) Modes in a Laser Cavity – G-quadruplex Targeting Small Instruction of Analog Signal Processing – Compact High Dynamic Range Mode-Locked Fiber Lasers – Antibody-Drug-Grafted Immune Cells Potential Vanilloid-1 (TRPV-1) – Automated Conversion of Corrosion – Silver-Silver Sulfide Reference Electrode HMD with Single Pass Relay – Method of Doping Molecules for the Treatment of for the Maintenance of Ocular Techniques at the Collegiate Level with Nanoparticles – Scattering-Based Light – Antimicrobial and Antiviral Therapy Castration Resistant Prostate Current to Corrosion Rate – Slepian-States-Based DV- and – Complex Diversity for Inverse Problems Sheet Microscope Surface Homeostasis – Hello Landlord – Method to Operate a Single-Frequency in Shrimp Using Genome Editing Cancer and HSV-1 – Automotive Radar Interference CV-QKD Schemes Suitable for – Curved Combiner – Silicone Aspherical Lens Array for – Molecular Imaging for High- WATER, ENVIRONMENTAL & ENERGY SOLUTIONS Mitigation Using Adaptive – Hybrid DV-CV QKD Outperforming Implementation in Integrated Optics External-Cavity Diode Laser – Antimicrobial and Antiviral Therapy – Gall Bladder Cryoablation Device Risk Carotid Plaques Existing QKD Protocols – Dual-Axis Tracker Using Lightweight Concentrating Solar Applications in Shrimp Using Genome Editing II Noise Canceller – Software Platform for the Collection – Methods and Apparatus for – Gallstone Dissolving Solution and – Natural Compounds to Treat – In The Americas with David Spaceframe Structures Confocal Endoscopes – Silicone Waveguide for Solar – Artificial Membranes Incorporating Method; Gallbladder Chemical – Bear Down Network App and Processing of Chemical Data Applications with High Concentration Alzheimer's Diseases – Automated Drone Date – Graphical User Interface for – Rearing Mealworms on Beer Yetman, Season 7 – Educational Content for Online Courses – Microcavity Surface Bioconjugation GPCRs for Label-Free, Ablation Solution and Method – Constitutions Toolbox – Swarms of Spacecraft for – Smartphone-Based Electrophysiological Measurements – Natural Language Processing Pollination System Drone on Date Palm Farm and Vegetable Waste in A – Insecta: Science That Stings Flyby Exploration, Mapping – Efficient All-Fiber Amplifier Based Using Unilamellar Lipid Membranes – Genetic Markers for Resistance and Deep Learning for Analysis Self-Contained System – Creation or Optimization of on Small Diameter Air Clad Fibers for Label-Free, Ultrasensitive Epifluorescence Microscope of Ligand- GPCR Interactions Against Acute Hepatopancreatic – Biocompatible Polymer for – Grasshopper Harvester NoC Routing Protocols and – Mapping the Borderlands: Online and Resource Prospecting of DNA Sequences Fugitive Dust Control – Superconducting Glyonic Liquids Mixed Media and Geolocated Social – Entanglement Assisted Detection of Alzheimer's Biomarkers – Snapshot Mueller Matrix Polarimeter – Barn Dust Extract Necrosis Disease (AHPND) in Shrimp – a Solution to Data- On-Processor Design – Systems and Methods for Detecting – Navigation Aids for the – Biosphere 2 Augmented Reality App Heavy Rangeland Research – The i-Abacus Green Box Engagement Platform for Education and Analyzing Response Bias Distributed Radars – Mobile Confocal Microscope – System and Method for – Baro-Balloon – Genetic Rat Model for Visually Impaired – Curriculum Materials for the Rapid Prototyping of 3D Pulmonary Hypertension – Continuous-Feed Solid-State – Metal Organic Framework with – The i-Incline Green Box Education of Graduate-Level – Mech-Elect-Generator – Teachers' Voices – Fast Gamma-Ray Interaction- – Mode Scrambler for Increasing – Beta-Adrenergic Receptor Activation – Nematocidal Activity of Three Position Estimation Numerical Aperture Heterogeneous Nanostructures to Increase the Potency and Safety of – Glycosylated Oxytocin Analogues Fermentation Module for Multicyclic Carbocation Linkers – The i-Sprout Green Box Measurement Science – Medical Interpreters – Tetrazine Vulcanization Agent for Secondary Metabolites Produced Mushroom Production Training Institute Units – Fast Volumetric Imaging of Fluorescent – Multiplexed Computed – Tactical Lighting Device Peripheral Blood Stem Cell Grafts for Non-Opioid Pain Relief and/ by the Entomopatogenic Bacteium – Multicyclic Carbocation-Metal – Deep Learning for SVD and Alkenyl-Modified Polymers Tissue Structures and Activities Tomography X-ray Imaging – Throttling, Descent and Landing of – Biomarker for Heart Failure or Addiction Treatment Photorhabdus l. Sonorensis – Control of Perovskite-Oxide Coordinated Compounds for Hybrid Beamforming – Michelle's Story – The Five C's: A Century Later Interfacial Defects Artificial Photosynthesis Devices – Gradient Index Microlens - – Nanosatellite Based Low- a Projectile Using Spin-Stabilization and Other Related Diseases – Hot Swappable Brain Implant – Neurological Disease and – Discretized Gaussian Modulation – Mobile Device App to Guide Visitors – The Workplace We Want© and Torque-Free Precession – Date Palm Tree Identification – Nanoparticles for UV-Free Activation (DGM)-Based Continuous Variable-QKD Through Design Day 2019 Method and Devices Cost Laser Communications – Blood-Based Inflammatory Biomarkers – Improved Properties and Injury Biomarker – Together We Heal Network for Low-Earth Orbit – Trapezoidal Shim for Segmented Predicting Allopregnanolone Synthesis of NanoSPA Particles and Centering Method of Photochemical Reactions – Distribution of Quantum Entanglement – NANO 2020: Multiplayer Networked – Grating Arrangement for – New Advanced Formulations of – Tomorrow Lab (Code of the Wild) Confocal Microscope – Novel Polymers for Mid- and Optics Assembly Therapeutic Response – Increasing 3HAA for Improving Cyanidin for Respiratory Diseases – Date Palm Tree Pollen Dispenser Device – Passive, Solar, Large-Scale Drying in an Underwater Environment Scientific Data Visualization and System for Agricultural Waste Scale Traversing in Virtual Reality – Topological Acoustic Sensing Long-Wave Infrared Imaging – Using Machine Learning to Create – Broad Spectrum Antivirals Response to and Recovery from Sepsis – New Libraries of Disulfide – Electrical Elicitation for Enhancement – Divine Mission: San Xavier del Bac – On-Chip Magnetometer High-Efficiency Optical Design Tools Against Enterovirus D68, A71, – Inhibitors of the DNA - KU70/80 Prochelators and Application of of Cell Growth and Production – Programmable Plants – Drone-Based LIDAR scanner – National Clinical Assessment Tool in – Tucson Remembers: Pearl Harbor – Virtual Deflectometry Enclosure Screen and Coxsackievirus B3 Association to Sensitize Cells for Treating Metal Ion Dysregulation of Secondary Metabolites Emergency Medicine and Web-Portal – Tucson Remembers: The – On-Chip CMOS Threshold Processing in Microalgae Cultures – Eliminating Deconvolution – White Light Interferometry Imager – Cognitive Assessment Using Upper- Radiation or Chemotherapy – New Strategies to Block RIPK1/ Artifacts with Softmax Function – Obfuscated Dynamic CAPTCHAs Battle for Europe extremity Motor Function – J Chain IRES CreERT2 Knockin RIPK3-Mediated Neurodegeneration – Environmentally-Friendly Dust – POSTER App for Out of School – Tucson Remembers: The Korean War Suppressant Polymer Blend – Enabling Search and Collaborative – Conjugation of the MCR1 Mice for Plasma Cell Research – Noninvasive Method of Treatment Assembly of Causal Interactions Time Professional Development – Tucson Remembers: The War Years Ligand with Cytotoxic Drugs for – Glyonic Liquids for Use as of Bone Fracture Using Carbon Extracted from Multilingual and – Preparacion Translating and – Tucson Remembers: War in the Pacific Targeted Melanoma Therapy Fiber Reinforcement Deep Eutectic Solvents Multi-Domain Free Text Interpreting Curriculum Units – Winning by Living: One Cancer Story – Publication and Research Manager MAKING IT HAPPEN A NEW TREATMENT FOR FIBROSIS

CHALLENGE Fibrotic disorders – the progressive buildup of scar tissue – are typically chronic and can often be fatal, causing 45 percent of deaths across the U.S. each year. As of today, there is no cure. SOLUTION A research team at the UArizona College of Medicine – Tucson and BIO5 Institute has been working diligently to understand the deeper workings of these diseases. Associate Professor of Medicine Louise Hecker, Senior Research Scientist Vijay Gokhale, and organic chemist Reena Chawla invented the first highly selective Nox4 small molecule inhibitors for the treatment of fibrotic disorders. Fibronox was created to commercialize the invention.

“With hundreds of failed clinical trials for fibrotic disease, there is a clear need for improved therapeutic strategies. Nox4 is the major cellular source of oxidant generation, and a drug targeting Nox4 would shut down oxidant production to combat

GUIDANCE FROM RECIPIENTS OF ASSET I-CORPS PROGRAM oxidative stress and stop the problem at the source.” MENTORS-IN-RESIDENCE DEVELOPMENT FUNDING GRADUATES —Louise Hecker, PhD, Associate Professor of Medicine, Inventor

CONTROLLING DUST IN A DRY WORLD GUIDANCE FROM MENTORS-IN-RESIDENCE RECIPIENTS OF ASSET DEVELOPMENT FUNDING

CHALLENGE SOLUTION "Most of my work has I-CORPS PROGRAM GRADUATES People living in dry climates Researchers at the UArizona College been about finding new worldwide experience the problems of Engineering and the BIO5 Institute things and contributing wrought by dry air and blowing developed an environmentally safe to science. I’m very dust, which affects everything from biocompatible polymer blend that, respiratory health to cars and other when added to water used for dust excited to know that machinery. To control dust in areas control, keeps the ground damp for my work is benefitting like mines and construction sites, the more than two months, even when all of society, not general practice is to spray the ground exposed to the open desert air. with water. While this method does just academia.” The technology was invented by keep dust levels down, sites require Assistant Professor of Mining and —Minkyu Kim, Ph.D. constant reapplication, especially Materials Engineering Minkyu Kim Assistant Professor of Mining in arid climates like Arizona. and Assistant Professor of Mining and and Materials Engineering Geological Engineering Kwangmin Kim. Working with TLA, Minkyu launched startup Clean Earth Tech to bring the solution to the world.

15 16 ASSET DEVELOPMENT

In FY2019, TLA funded 16 new asset development projects crossing multiple colleges and disciplines to move early-stage inventions toward being licensable, market-ready projects.

16 NEW PROJECTS FUNDED

2019 16

2018 16

2017 15

2016 27

2015 17

AWARD COUNT PER UNIT Arizona Health Sciences 10 A NEW BLOOD TEST FOR CANCER College of Engineering 7

College of Optical Sciences 4 CHALLENGE “Being involved in the I-Corps program and working When testing for diseases such with TLA has been a very positive experience for

College of Agriculture & Life Sciences 2 as lung cancer, doctors know that us. We’ve received great support and advice as we tissue biopsies are necessary and move toward commercialization. We are excited potentially life-saving, though the College of Science 4 procedures used to gather tissue can about our technology, which we’re calling DDX- lead to dangerous complications, Sentinel, and its potential to help patients." from bleeding to lung collapse. Dr. Mark Nelson, Professor of Pathology & DesertDx Chief Executive Officer AWARD AMOUNTS BY UNIT

Arizona Health Sciences $260,928 SOLUTION To lower the need for invasive the University of Arizona Cancer – a blood test for screening, College of Engineering $225,820 procedures, Dr. Bernard Futscher, Center, combined the latest detecting and monitoring cancer. professor at the UArizona College discoveries in epigenetics with new Together with Dr. Mark Nelson they College of Optical Sciences $135,286 of Pharmacy, and Dr. Lukas Vrba, methods in informatics to create launched DesertDx to bring the assistant research scientist at a new breed of “liquid biopsy” College of Agriculture & Life Sciences $105,135 invention to doctors and their patients.

College of Science $42,312 GUIDANCE FROM RECIPIENTS OF ASSET I-CORPS PROGRAM Other $7,251 MENTORS-IN-RESIDENCE DEVELOPMENT FUNDING GRADUATES

17 18 VENTURE DEVELOPMENT

Economic impact of UArizona 71 $585.7M $25.4M STARTUPS LAUNCHED POSITIVE ECONOMIC GENERATED FROM STATE Startups from 2016 through 2018.* THROUGH FY18 IMPACT FOR ARIZONA & LOCAL TAXES

*Source: McGuire Center for Entrepreneurship (June 2019). The Economic Impact of Tech Launch Arizona (TLA) 5,236 $251.5M $14.24 and the TLA-Linked Companies it has Enabled (2016, 2017, and 2018); and potential future economic impact. JOBS CREATED & INCOME FROM IN EMPLOYMENT INCOME EMPLOYMENT GROWTH EMPLOYMENT LABOR GENERATED FOR EVERY $1 SPENT

FY2019 ICRX, INC. EARDG PHOTONICS, INC. PROCYON TECHNOLOGIES CLEAN EARTH TECH FIBRONOX Developing a holographic binocular Developer of enhanced augmented Developing an artificial pancreas Bringing a new biocompatible Working to treat fibrotic disorders STARTUPS adaptive see-through phoropter. reality display glasses. cell encapsulation device. material for dust control to market. with Nox4 small molecular inhibitors. James C. Wyant College of Optical James C. Wyant College College of Medicine - Phoenix College of Engineering College of Medicine | BIO5 Institute Sciences | College of Medicine - Tucson of Optical Sciences | BIO5 Institute

SCINTILLATION NANOTECHNOLOGIES DESERTDX XORALGO, INC. SIDECAR LEARNING EXTREME CER NANO INTELICO THERAPEUTICS Bringing to market novel nanoparticles for the detection Developing an approach to directly Bringing to market an error correction Bringing to market a web-based Developing a high temperature Drug target discovery and of radioisotope activity. identify cancer-specific methylation method that improves database failure tool to build engaging and graphene-based ceramic material precision therapeutics based upon regions within the human genome. rate, increases speed and storage rate pedagogically sound tutorials. for extreme environments. probabilistic models of disease. College of Science | College of over the current RAID 6 technology. Medicine – Tucson | BIO5 Institute College of Pharmacy | BIO5 Institute UArizona Library College of Engineering College of Medicine - Tucson | UArizona Cancer Center | UArizona Cancer Center College of Science

1,600 COMMERCIAL NETWORK MEMBERS NSF I-CORPS

Through volunteering their expertise, TLA’s 1,600 Commercialization Network members provide input to TLA employees TLA has continued to deliver the I-Corps program over the past year. and teams as they develop strategies and pathways to move new UArizona technologies into the public sphere. Having completed our three-year grant, the NSF has provided an extension to allow us to continue to provide the beneficial program to UArizona 30 COMMERCIALIZATION PARTNERS 4 MENTORS-IN-RESIDENCE startup teams. Through I-Corps, TLA offers grants of up to $3,000 to university-related entrepreneurial teams working to bring their inventions Some of our network members want greater These seasoned technology entrepreneurs help startup to the world, with those funds going towards customer discovery. involvement. They are looking for their next teams grow technologies into successful ventures. entrepreneurial opportunity and want a closer, earlier look at emerging technologies. Through 76 SHORT-TERM ENGAGEMENTS 117 TEAMS SERVED 27 TEAMS SERVED our Commercialization Partner program, we have have been made between network members and startups. since TLA was named an in FY 2019. engaged 30 individuals who regularly participate I-Corps site in 2016. in team meetings, offering indispensable advice, 6 LEADERSHIP POSITIONS connections and perspectives to our conversations. in startups have been filled by network members this year.

19 20 A TEAM TO #MAKEITHAPPEN

Thank you to every team member for making this past year such a success. From our advisory board to the community of UArizona inventors to all of our ecosystem members and of course our staff, we couldn’t have the impact that we do without everyone’s contributions.

THANK YOU. TECH LAUNCH ARIZONA ADVISORY BOARD

ANDY LOMBARD ANGELA PEREZ DAVID SMALLHOUSE FLETCHER J. MCKUSKER HARRY GEORGE JOHN-PAUL ROCZNIAK Executive Vice President Attorney Managing Director CEO Managing General Partner President & Chief Executive Officer Business Development, Arizona Snell & Wilmer Miramar Ventures UAVenture Capital Solstice Capital Partnership University of Arizona Foundation Commerce Authority

MARA ASPINALL ROBERT GRIFFIN STEVE BROADBENT WAIN FISHBURN JON DUDAS KIRSTEN LEUTE Managing Director Managing Partner Chief Operating Officer Partner Sr. Associate to the President Senior Vice President of and Secretary of the University University Relations, BlueStone Venture Partners DVI Equity Partners Critical Path Institute (C-Path) Cooley LLP The University of Arizona Osage University Partners

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THANK YOU TO OUR SPONSORS

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