TICKBORNE DISEASES OF THE UNITED STATES A Reference Manual for Health Care Providers Fourth Edition, 2017 Tick ID BLACKLEGGED TICK LONE STAR TICK AMERICAN DOG TICK Ixodes scapularis Amblyomma americanum Dermacentor variabilis Where found: Widely distributed in the Where found: Widely distributed in the Where found: Widely distributed east northeastern and upper midwestern southeastern and eastern United States. of the Rocky Mountains. Also occurs in United States. Transmits: Ehrlichia chaffeensis and limited areas on the Pacific Coast. Transmits: Lyme disease, anaplasmosis, Ehrlichia ewingii (which cause human Transmits: Tularemia and Rocky babesiosis, and Powassan disease. ehrlichiosis), tularemia, and STARI. Mountain spotted fever. Comments: The greatest risk of being Comments: A very aggressive tick that bites Comments: The highest risk of being bitten exists in the spring, summer, humans. The adult female is distinguished by bitten occurs during spring and and fall. However, adults may be out a white dot or “lone star” on her back. Lone summer. Dog ticks are sometimes searching for a host any time winter star tick saliva can be irritating; redness and called wood ticks. Adult females are temperatures are above freezing. Stages discomfort at a bite site does not necessarily most likely to bite humans. most likely to bite humans are nymphs indicate an infection. The nymph and adult and adult females. females most frequently bite humans and transmit disease. Engorged female Ixodes scapularis tick. Color may vary. NOTE: Illustrations are not to scale. 2 Rocky Other Tick Lyme Tick Bites/ Maps Anaplasmosis Babesiosis Ehrlichiosis Mountain Tularemia Tickborne ID Disease Prevention Spotted Fever Diseases Tick ID Steve Jacobs, PSU Entomology Jacobs, Steve BROWN DOG TICK GROUNDHOG TICK GULF COAST TICK Rhipicephalus sanguineus Ixodes cookei Amblyomma maculatum Where found: Worldwide. Where found: Throughout the eastern Where found: Coastal areas of the U.S. Transmits: Rocky Mountain spotted half of the U.S. and Canada. along the Atlantic coast and the Gulf of fever (in the southwestern U.S. and along Transmits: Powassan disease. Mexico. the U.S.-Mexico border). Comments: Also called woodchuck ticks. Transmits: Rickettsia parkeri rickettsiosis, Comments: Dogs are the primary host All life stages feed on a variety of warm- a form of spotted fever. for the brown dog tick in each of its blooded animals, including groundhogs, Comments: Larvae and nymphs feed life stages, but the tick may also bite skunks, squirrels, raccoons, foxes, on birds and small rodents, while adult humans or other mammals. weasels, and occasionally people and ticks feed on deer and other wildlife. domestic animals. Adult ticks have been associated with transmission of R. parkeri to humans. tick, before and after feeding. feeding. and after tick, before O. hermsi O. Photo taken by Gary by taken RML, NIAID. Photo Hettrick ROCKY MOUNTAIN SOFT TICK WESTERN BLACKLEGGED TICK WOOD TICK Ornithodoros spp. Ixodes pacificus Dermacentor andersoni Where found: Throughout the western Where found: Along the Pacific coast of the U.S., particularly northern California. Where found: Rocky Mountain states half of the U.S. and southwestern and southwestern Canada from Canada. Transmits: Anaplasmosis and Lyme elevations of 4,000 to 10,500 feet. Transmits: Tick-borne relapsing disease. Transmits: Rocky Mountain spotted fever (Borrelia hermsii, B. parkerii, or Comments: Nymphs often feed on fever, Colorado tick fever, and tularemia. B. turicatae) lizards, as well as other small animals. As a result, rates of infection are usually low Comments: Adult ticks feed primarily Comments: Humans typically come (~1%) in adults. Stages most likely to bite on large mammals. Larvae and nymphs into contact with soft ticks when they humans are nymphs and adult females. feed on small rodents. Adult ticks are sleep in rodent infested cabins. The ticks primarily associated with pathogen emerge at night and feed briefly while transmission to humans. the person is sleeping. The bites are painless, and most people are unaware that they have been bitten. 3 Rocky Other Tick Lyme Tick Bites/ Maps Anaplasmosis Babesiosis Ehrlichiosis Mountain Tularemia Tickborne ID Disease Prevention Spotted Fever Diseases Overview of Tickborne Diseases Selected Tickborne Diseases Reported to CDC, U.S., 2015 Anaplasmosis Babesiosis Ehrlichiosis Lyme Disease Rocky Mountain Spotted Fever Tularemia NOTE: Each dot represents one case. Cases are reported from the infected person’s county of residence, not necessarily the place where they were infected. NOTE: During 2015, babesiosis was reportable in Alabama, Arkansas, California, Connecticut, Delaware, Illinois, Indiana, Louisiana, Kentucky, Maine, Maryland, Massachusetts, Michigan, Minnesota, Montana, Nebraska, New Hampshire, New Jersey, New York, North Dakota, Ohio, Oregon, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Washington, West Virginia, Wisconsin, and Wyoming. NOTE: In 2015, no cases of tickborne illness were reported from Hawaii. In 2015, Alaska reported 1 travel-related cases of Lyme disease and 2 cases of tularemia. 4 Rocky Other Lyme Tick Bites/ Maps Anaplasmosis Babesiosis Ehrlichiosis Mountain Tularemia Tickborne Disease Prevention Spotted Fever Diseases AGENT Anaplasmosis Anaplasma phagocytophilum WHERE FOUND Anaplasmosis is most frequently reported from the upper midwest and northeastern U.S. in areas that correspond with the known geographic distribution of Lyme disease. INCUBATION PERIOD: 1–2 weeks The Signs and Symptoms list presents symptoms commonly seen with anaplasmosis. However, it is important to note that few people SIGNS AND SYMPTOMS will develop all symptoms and the number and combination of • Fever, shaking, chills symptoms varies greatly from person to person. • Severe headache • Malaise Anaplasmosis and ehrlichiosis have similar clinical Myalgia • presentations, but they are transmitted by two different • Gastrointestinal symptoms (nausea, vomiting, species of ticks and generally occur in different regions of diarrhea, anorexia) the U.S. • Cough Anaplasmosis was formerly known as Human Granulocytic • Rash (rare cases) Ehrlichiosis (HGE). Confirmation of the diagnosis is based on laboratory testing, but antibiotic therapy should not be delayed in a patient with a suggestive clinical presentation. GENERAL LABORATORY FINDINGS NOTE: IgM antibodies are less specific than IgG antibodies Typically Observed During the First Week of Clinical Disease: and are more likely to generate false positives. IgM results alone should not be used for laboratory • Mild anemia diagnosis. • Thrombocytopenia • Leukopenia (characterized by relative and absolute lymphopenia NOTE: Consider the possibility of coinfection with Babesia and a left shift) microti and/or Borrelia burgdorferi. Mild to moderate elevations in hepatic transaminases may occur in • NOTE: Antibody titers are frequently negative in the first some patients. 7–10 days of illness, thus serologic tests may be • Visualization of morulae in the cytoplasm of granulocytes during falsely negative during this time period. examination of blood smears is highly suggestive of a diagnosis; however, blood smear examination is insensitive and should never be relied upon solely to rule anaplasmosis in or out. LABORATORY CONFIRMATION • Detection of DNA by PCR of whole blood. This method is most sensitive during the first week of illness; sensitivity may decrease after administration of antibiotics. • Demonstration of a four-fold change in IgG-specific antibody titer by indirect immunofluorescence antibody (IFA) assay in paired serum samples. Antibodies to A. phagocytophilum are usually detectable within 7–10 days after illness onset. The reference standard serologic test looks for a four-fold change in antibody titers using IFA on paired samples. The first sample should be taken within the first week of illness and the second should be 5 taken 2 to 4 weeks later. Rocky Other Lyme Tick Bites/ Anaplasmosis Babesiosis Ehrlichiosis Mountain Tularemia Tickborne Disease Prevention Spotted Fever Diseases AGENT Anaplasmosis Anaplasma phagocytophilum Anaplasmosis, ehrlichiosis, and Rocky Mountain spotted fever are treated in the same manner with doxycycline. Clinical suspicion of any of these diseases is sufficient to begin treatment. Delay in treatment may result in severe illness and even death. The regimens listed below are guidelines only and may need to be adjusted depending on a patient’s age, medical history, underlying health conditions, pregnancy status, or allergies. Consult an infectious disease specialist in cases of documented pregnancy or life- threatening allergies to doxycycline. AGE CATEGORY DRUG DOSAGE MAXIMUM DURATION (DAYS) Adults Doxycycline 100 mg twice per day, orally or IV 100 mg/dose Patients with suspected anaplasmosis infection should be treated with doxycycline for 10-14 days to provide appropriate length of therapy for possible incubating co-infection with Children weighing 2.2 mg/kg per dose twice per Doxycycline 100 mg/dose Lyme disease <100 lbs. (45.4 kg) day, orally or IV NOTE: Use doxycycline as first-line treatment for suspected anaplasmosis in patients of all ages. The use of doxycycline to treat suspected anaplasmosis in children is recommended by both the CDC and the American Academy of Pediatrics Committee on Infectious Diseases. Use of antibiotics other than doxycycline increases the risk of patient death. At the recommended dose and duration needed to treat