Additional Table 5 The down-regulated GO and KEGG terms. #TotalGe #GeneIn FirstInGro FirstInGro BestEnric _MEMBER _LogP_In _PATTER CategoryI Enrichme #GeneIn #GeneIn STDV Log(q- Evidence GROUP_I BestLogPI GO _RANK_ GiniIndex Category Description LogP Z-score neInLibrar GOAndHi %InGO GeneID Hits upByEnric upByLog hmentInG URL _Input ID put ID N_ D nt GO HitList %InGO value) Cutoff D nGroup y tList hment P roup 655|954|1 BMP7|EN 287|1288| TPD2|CO 1289|129 L4A5|COL 4|1295|12 4A6|COL5 99|1306|1 A1|COL7 462|1490| A1|COL8 1805|219 A1|COL9 9|2200|22 A3|COL15 01|2239|2 A1|VCAN| 335|3263| CCN2|DP 3909|391 T|FBLN2|F 4|3958|40 BN1|FBN 17|4052|4 2|GPC4|F GO 053|4060| N1|HPX|L GO:00310 Cellular 1 -22.6822 M1 1 0 20 extracellular matrix -22.6822 3.827267 12.80518 24156 535 873 74 8.476518 0.942688 4237|431 AMA3|LA -18.2443 0 1 1 1 -22.6822 5.869416 12 Compone 2|4316|49 MB3|LGA nts 69|5270|6 LS3|LOXL 387|6422| 2|LTBP1|L 7057|705 TBP2|LU 8|7078|70 M|MFAP2 79|7980|8 |MMP1|M 483|9423| MP7|OG 9508|971 N|SERPIN 9|9865|10 E2|CXCL1 216|1051 2|SFRP1|T 6|10631|1 HBS1|THB 1081|232 S2|TIMP3| 13|23768| TIMP4|TF 25878|25 PI2|CILP| 332|580|6 BIRC5|BA 72|675|69 RD1|BRC 9|701|894 A1|BRCA2 |983|1021 |BUB1|BU |1030|106 B1B|CCN 2|1063|18 D2|CDK1| 70|2491|3 CDK6|CD 015|3161| KN2B|CE 4001|417 NPE|CEN 5|4361|47 PF|E2F2|C 51|4998|4 ENPI|H2A 999|5116| Z1|HMM 5558|593 R|LMNB1| 1|6241|67 MCM6|M R-HSA- Reactome 1 -22.074 M1 1 0 6 Cell Cycle -22.074 3.412509 12.2911 24156 673 873 83 9.507446 0.99273 90|7029|7 RE11|NEK -17.9371 0 2 1 1 -22.074 10.54099 1640170 Gene Sets 153|7465| 2|ORC1|O 8317|831 RC2|PCN 8|8357|86 T|PRIM2| 55|9133|9 RBBP7|RR 134|9156| M2|AURK 9232|949 A|TFDP2| 3|9662|98 TOP2A|W 14|10051| EE1|CDC7 10403|10 |CDC45|H 592|1073 3C10|DY 3|11004|2 NLL1|CC 2974|233 NB2|CCN 97|23421| E2|EXO1| 51512|54 PTTG1|KI GO 6387|877 CXCL12|F GO:00026 1 -1.47801 M1 1 0 Biological 19 regulation of cellular extravasation -1.47801 3.255306 2.548176 24156 34 873 4 0.45819 0.22857 2|83483|7 ADD|PLV -0.34267 0 0 91 Processes 29230 AP|CCR2 MET|PEC GO 4233|517 GO:00033 AM1|ARH 1 -1.47801 M1 1 0 Biological 19 epithelial cell morphogenesis -1.47801 3.255306 2.548176 24156 34 873 4 0.45819 0.22857 5|26084|6 -0.34267 0 0 82 GEF26|TN Processes 4102 MD 655|954|1 BMP7|EN 287|1288| TPD2|CO 1289|129 L4A5|COL 4|1295|12 4A6|COL5 99|1306|1 A1|COL7 462|1490| A1|COL8 1805|219 A1|COL9 9|2200|22 A3|COL15 01|2239|2 A1|VCAN| 335|3263| CCN2|DP 3909|391 T|FBLN2|F 4|3958|40 BN1|FBN 17|4052|4 2|GPC4|F GO 053|4060| N1|HPX|L GO:00620 Cellular 1 -18.9887 M1 1 0 20 collagen-containing extracellular matrix -18.9887 3.981795 11.79141 24156 410 873 59 6.758305 0.849605 4237|496 AMA3|LA -15.3253 0 1 0 0 -22.6822 5.869416 23 Compone 9|5270|63 MB3|LGA nts 87|6422|7 LS3|LOXL 057|7058| 2|LTBP1|L 7078|848 TBP2|LU 3|9423|95 M|MFAP2 08|10216| |OGN|SER 10516|10 PINE2|CX 631|2321 CL12|SFR 3|25878|2 P1|THBS1 5975|552 |THBS2|TI 14|64129| MP3|CILP 79148|79 |NTN1|AD 812|8076 AMTS3|P 0|83872|8 RG4|FBLN 332|699|7 BIRC5|BU 01|894|98 B1|BUB1B 3|1021|10 |CCND2|C 30|1062|1 DK1|CDK 063|1870| 6|CDKN2 2491|301 B|CENPE| 5|3161|40 CENPF|E2 01|4175|4 F2|CENPI| 751|4998| H2AZ1|H 4999|511 MMR|LM 6|5558|62 NB1|MC 41|6790|7 M6|NEK2| 029|7153| ORC1|OR 7465|831 C2|PCNT| R-HSA- Reactome 1 -18.9637 M1 1 0 6 Cell Cycle, Mitotic -18.9637 3.458763 11.39942 24156 560 873 70 8.018328 0.919148 7|8318|83 PRIM2|RR -15.3253 0 2 0 0 -22.074 10.54099 69278 Gene Sets 57|8655|9 M2|AURK 133|9134| A|TFDP2| 9232|949 TOP2A|W 3|9662|98 EE1|CDC7 14|10051| |CDC45|H 10403|10 3C10|DY 592|1073 NLL1|CC 3|11004|2 NB2|CCN 2974|233 E2|PTTG1 97|23421| |KIF23|CE 51512|54 P135|SFI1 820|5482 |SMC4|N 1|54892|5 DC80|SM 5125|553 C2|PLK4|K GO 1003|328 CDH5|HE GO:00305 positive regulation of BMP signaling 1 -1.47801 M1 1 0 Biological 19 -1.47801 3.255306 2.548176 24156 34 873 4 0.45819 0.22857 0|4089|23 S1|SMAD -0.34267 0 0 13 pathway Processes 213 4|SULF1 GO 4060|496 LUM|OG GO:00423 1 -1.47801 M1 1 0 Biological 19 keratan sulfate metabolic process -1.47801 3.255306 2.548176 24156 34 873 4 0.45819 0.22857 9|11081|9 N|KERA|B -0.34267 0 0 39 Processes 3010 3GNT7 GO 1030|530 CDKN2B| GO:00485 1 -1.47801 M1 1 0 Biological 19 spleen development -1.47801 3.255306 2.548176 24156 34 873 4 0.45819 0.22857 8|8772|80 PITX2|FA -0.34267 0 0 36 Processes 169 DD|CTC1 GO 655|2103| BMP7|ES GO:20000 regulation of stem cell population 1 -1.47801 M1 1 0 Biological 19 -1.47801 3.255306 2.548176 24156 34 873 4 0.45819 0.22857 4017|104 RRB|LOXL -0.34267 0 0 36 maintenance Processes 13 2|YAP1 1287|128 COL4A5| 8|1289|12 COL4A6| 94|1295|1 COL5A1| 299|1306| COL7A1| 1462|149 COL8A1| 0|1805|21 COL9A3| 99|2200|2 COL15A1| 201|2335| VCAN|CC 3909|391 N2|DPT|F 4|4052|40 BLN2|FBN 53|4060|4 1|FBN2|F 237|4969| N1|LAMA 7057|705 3|LAMB3| 8|7130|84 LTBP1|LT Canonical 1 -17.5073 M5884 M1 1 0 11 NABA CORE MATRISOME -17.5073 4.628454 11.71798 24156 275 873 46 5.269187 0.756154 83|9423|1 BP2|LUM| -14.1441 0 1 0 0 -22.6822 5.869416 Pathways 0216|105 MFAP2|O 16|10631| GN|THBS 11081|11 1|THBS2| 082|2587 TNFAIP6| 8|64129|7 CILP|NTN 9812|838 1|PRG4|F 72|84467| BLN5|PO 84570|84 STN|KERA 624|1318 |ESM1|M 73|13358 XRA5|TIN 4|136227| AGL1|MM 137902|1 RN2|HMC 45864|28 N1|FBN3| 4217|340 COL25A1| HES1|SM 3280|408 AD4|MEF 9|4208|42 2C|MEOX 22|5081|5 1|PAX7|P 125|5308| CSK5|PIT 5992|642 X2|RFX4|S GO 2|6790|69 GO:00030 FRP1|AUR 1 -1.47521 M1 1 0 Biological 19 regionalization -1.47521 1.563283 2.067343 24156 354 873 20 2.290951 0.50637 39|8726|8 -0.34008 0 0 02 KA|TCF15 Processes 854|9096| |EED|ALD 10736|23 H1A2|TBX 237|5109 18|SIX2|A 8|54567|5 RC|IFT52| 5502|441 DLL4|HES 478 6|NRARP COL4A5| COL4A6| COL5A1| 1287|128 COL7A1| 8|1289|12 COL8A1| 94|1295|1 COL9A3| 299|1306| COL15A1| 1462|180 VCAN|DP 5|2199|22 T|FBLN2|F 00|2201|2 BN1|FBN 335|3909| 2|FN1|LA 3914|405 MA3|LAM 2|4053|40 GO B3|LTBP1| GO:00052 60|4237|4 1 -16.7916 M1 1 0 Molecular 21 extracellular matrix structural constituent -16.7916 5.869416 12.15307 24156 165 873 35 4.009164 0.663949 LTBP2|LU -13.4676 0 1 0 0 -22.6822 5.869416 01 969|7057| Functions M|MFAP2 7058|798 |OGN|TH 0|8483|10 BS1|THBS 216|1051 2|TFPI2|CI 6|10631|2 LP|PRG4|F 5878|641 BLN5|PO 29|79812| STN|MXR 83872|84 A5|TINAG 467|8457 L1|MMRN 0|131873| 2|HMCN1 284217 |FBN3|CO L25A1|CO L6A6|LA ADORA2 135|3624| A|INHBA| 3958|515 LGALS3|P 6|5169|52 DGFRA|E GO 70|6422|7 NPP3|SER GO:00508 1 -1.47425 M1 1 0 Biological 19 negative regulation of cell activation -1.47425 1.771977 2.138768 24156 203 873 13 1.489118 0.40992 056|5582 PINE2|SF -0.33951 0 0 66 Processes 4|79679|1 RP1|THB 70692|44 D|PAG1|V 1478|729 TCN1|AD 230 AMTS18| NRARP|C ASPA|MB 443|4155| P|NTRK3| 4916|501 CLDN11| GO GO:00072 0|5354|71 PLP1|TNF 1 -1.47359 M1 1 0 Biological 19 ensheathment of neurons -1.47359 1.948599 2.195259 24156 142 873 10 1.145475 0.360151 -0.33951 0 0 72 33|7852|8 RSF1B|CX Processes 537|9928| CR4|BCAS 58494 1|KIF14|JA M2 BIRC5|BU B1|BUB1B 332|699|7 |CDK1|CE 01|983|10 NPE|CEN 62|1063|2 PF|CENPI| 491|4751| NEK2|PC 5116|865 NT|DYNL 5|9133|96 L1|CCNB2 62|9814|1 |CEP135|S 0051|104 FI1|SMC4| 03|10592| NDC80|S 10733|11 MC2|PLK 004|2339 4|KIF2C|N 7|23421|5 R-HSA- Reactome CAPH|ITG 1 -16.166 M1 1 0 6 Mitotic Prometaphase -16.166 5.154235 11.53789 24156 204 873 38 4.352806 0.690579 4820|548 -12.9322 0 2 0 0 -22.074 10.54099 68877 Gene Sets B3BP|ND 21|55125| E1|ERCC6 55835|55 L|CEP192| 839|5708 CENPJ|CE 2|57405|6 NPN|KNL 4151|790 1|SPC25| 03|79441| NCAPG| 79861|80 MIS12|HA 184|8102 US3|TUB 7|81930|8 AL3|CEP2 3540|916 90|TUBB1 87|12144 |KIF18A|N 1|401541 UF2|CEN PL|NEDD ENTPD2| COL4A5| 954|1287| COL4A6| 1288|128 COL5A1| 9|1294|12 COL7A1| 95|1306|2 COL8A1| 200|2335| COL15A1| 3909|391 FBN1|FN1 4|4017|70 |LAMA3|L GO 58|7078|9 AMB3|LO GO:00056 Cellular 423|2597 1 -15.2617 M1 1 0 20 basement membrane -15.2617 7.416729 12.26174 24156 97 873 26 2.978236 0.575317 XL2|THBS -12.0543 0 5 1 1 -15.2617 12.29782 04 Compone 5|55214|7 2|TIMP3| nts 9812|838 NTN1|EG 72|13358 FL6|P3H2| 4|151887| MMRN2| 158326|1 HMCN1|E 66752|28 GFLAM|C 4217|341 CDC80|FR 640|3755 EM1|FRE 67 M3|LAMA 1|FREM2| ASPA|MB 443|4155| P|NTRK3| 4916|501 CLDN11| GO GO:00083 0|5354|71 PLP1|TNF 1 -1.47359 M1 1 0 Biological 19 axon ensheathment -1.47359 1.948599 2.195259 24156 142 873 10 1.145475 0.360151 -0.33951 0 0 66 33|7852|8 RSF1B|CX Processes 537|9928| CR4|BCAS 58494 1|KIF14|JA M2 ACTN1|B 87|655|12 MP7|COL 87|1288|1 4A5|COL4 289|1294| A6|COL5 1295|129 A1|COL7 9|1306|14 A1|COL8 62|2199|2 A1|COL9 200|2201| A3|COL15 2247|233 A1|VCAN| 5|3672|36 FBLN2|FB 73|3690|3 N1|FBN2| 691|3909| FGF2|FN1 3914|401 |ITGA1|IT 7|4052|40 GA2|ITGB R-HSA- Reactome 53|4060|4 1 -14.5406 M1 1 0 6 Extracellular matrix organization -14.5406 4.044799 10.29303 24156 301 873 44 5.040092 0.740427 3|ITGB4|L -11.3815 0 5 0 0 -15.2617 12.29782 1474244 Gene Sets 237|4312| AMA3|LA 4316|517 MB3|LOX 5|7057|70 L2|LTBP1| 93|9508|1 LTBP2|LU 0491|105 M|MFAP2 16|55214| |MMP1|M 58494|84 MP7|PEC 467|8457 AM1|THB 0|131873| S1|TLL2|A 136227|1 DAMTS3| 70692|22 CRTAP|FB 2663|284 LN5|P3H2 217|4408 |JAM2|FB 54 N3|COL2 CDH5|EP 1003|204 HB1|HES1 7|3280|69 |TCF15|W GO 39|7465|9 GO:00300 EE1|KIF20 1 -1.47359 M1 1 0 Biological 19 establishment of cell polarity -1.47359 1.948599 2.195259 24156 142 873 10 1.145475 0.360151 585|1040 -0.33951 0 0 10 B|NDC80| Processes 3|54820|7 NDE1|MC 9648|284 PH1|LAM 217 A1 CDK6|FB GO 1021|220 GO:00027 negative regulation of myeloid leukocyte N1|INHB 1 -1.4707 M1 1 0 Biological 19 -1.4707 2.76701 2.42188 24156 50 873 5 0.572738 0.255402 0|3624|64 -0.33951 0 0 62 differentiation A|SFRP1| Processes 22|8111 GPR68 AGTR2|D GO 186|1816| GO:00030 regulation of systemic arterial blood RD5|EDN 1 -1.4707 M1 1 0 Biological 19 -1.4707 2.76701 2.42188 24156 50 873 5 0.572738 0.255402 1907|190 -0.33951 0 0 44 pressure mediated by a chemical signal 2|EDN3|P Processes 8|5125 CSK5 BIRC5|BU 332|699|7 B1|BUB1B 01|1062|1 |CENPE|C 063|2491| ENPF|CE 3070|475 NPI|HELL 1|4999|67 S|NEK2|O 90|7272|8 RC2|AUR 655|1040 KA|TTK|D 3|11004|2 YNLL1|N 3421|270 DC80|KIF GO 85|54820| 2C|ITGB3 GO:00007 Cellular 1 -12.129 M1 1 0 20 chromosome, centromeric region -12.129 4.540735 9.612789 24156 195 873 32 3.665521 0.635992 54821|55 BP|MTBP| -9.05281 0 2 0 0 -22.074 10.54099 75 Compone 355|5583 NDE1|ER nts 9|56155|5 CC6L|HJU 7082|574 RP|CENP 05|64151| N|TEX14| 79003|79 KNL1|SPC 075|7972 25|NCAP 3|81930|8 G|MIS12| 3540|916 DSCC1|S 87|22115 UV39H2| 0|401541 KIF18A|N UF2|CEN 332|675|6 BIRC5|BR 99|701|98 CA2|BUB 3|1062|10 1|BUB1B| 63|2491|3 CDK1|CE 070|4175| NPE|CEN 4361|475 PF|CENPI| 1|4998|49 HELLS|M 99|6790|7 CM6|MRE 272|7520| 11|NEK2| 8655|993 ORC1|OR 7|10403|1 C2|AURK 1004|234 A|TTK|XR 21|27085| CC5|DYN GO 54780|54 LL1|DCLR GO:00986 Cellular 1 -12.0937 M1 1 0 20 chromosomal region -12.0937 3.458763 8.99817 24156 352 873 44 5.040092 0.740427 820|5482 E1A|NDC -9.03601 0 2 0 0 -22.074 10.54099 87 Compone 1|55183|5 80|KIF2C|I nts 5355|555 TGB3BP| 06|55839| MTBP|NS 56155|57 MCE4A|N 082|5740 DE1|ERCC 5|64151|7 6L|RIF1|H 9003|790 JURP|MA 75|79723| CROH2A 80119|80 2|CENPN| 169|8193 TEX14|KN 0|83540|9 L1|SPC25| 1687|221 NCAPG| 150|4015 MIS12|DS 41 CC1|SUV BMP7|LO GO 655|4017| GO:00107 positive regulation of epithelial to XL2|SMA 1 -1.4707 M1 1 0 Biological 19 -1.4707 2.76701 2.42188 24156 50 873 5 0.572738 0.255402 4089|707 -0.33951 0 0 18 mesenchymal transition D4|TIAM1 Processes 4|28984 |RGCC BIRC5|BR CA1|BRC 332|672|6 A2|BUB1| 75|699|70 BUB1B|CE 1|1062|10 NPE|CEN 63|2103|4 PF|ESRRB| 288|4751| MKI67|NE 4999|679 K2|ORC2| 0|7153|10 AURKA|T 051|1040 OP2A|SM 3|10592|1 C4|NDC8 GO 1004|233 0|SMC2|K GO:00007 Cellular 97|23421| 1 -11.8474 M1 1 0 20 condensed chromosome -11.8474 4.199926 9.316776 24156 224 873 34 3.894616 0.654786 IF2C|NCA -8.82778 0 2 0 0 -22.074 10.54099 93 Compone 54780|54 PH|ITGB3 nts 820|5482 BP|NSMC 1|54892|5 E4A|NDE 5183|553 1|ERCC6L| 55|55839| NCAPG2| 56155|57 RIF1|HJU 082|5740 RP|CENP 5|64151|7 N|TEX14| 9003|835 KNL1|SPC 40|15028 25|NCAP 0|221150 G|MIS12| NUF2|HO CHRNA1| GO 1134|138 GO:00350 CREB1|PE 1 -1.4707 M1 1 0 Biological 19 response to nicotine -1.4707 2.76701 2.42188 24156 50 873 5 0.572738 0.255402 5|5179|70 -0.33951 0 0 94 NK|TH|PP Processes 54|84687 P1R9B 332|699|7 BIRC5|BU 01|983|10 B1|BUB1B 62|1063|2 |CDK1|CE 491|3015| NPE|CEN 4001|475 PF|CENPI| 1|5116|83 H2AZ1|L 57|8655|9 MNB1|NE 133|9232| K2|PCNT| 9493|966 H3C10|D 2|9814|10 YNLL1|CC 051|1040 NB2|PTT 3|10592|1 G1|KIF23| 0733|110 CEP135|S 04|23397| FI1|SMC4| R-HSA- Reactome 1 -11.8053 M1 1 0 6 M Phase -11.8053 3.185048 8.715432 24156 417 873 48 5.498282 0.771483 23421|54 NDC80|S -8.81454 0 2 0 0 -22.074 10.54099 68886 Gene Sets 820|5482 MC2|PLK 1|54892|5 4|KIF2C|N 5125|557 CAPH|ITG 06|55835| B3BP|ND 55839|57 E1|ERCC6 082|5740 L|NCAPG 5|64151|7 2|CEP192| 9003|794 NDC1|CE 41|79648| NPJ|CENP 79861|80 N|KNL1|S 184|8102 PC25|NC 7|81930|8 APG|MIS1 3540|849 2|HAUS3| 30|91687| MCPH1|T 1021|233 CDK6|FN GO GO:00481 positive regulation of fibroblast 5|5156|56 1|PDGFR 1 -1.4707 M1 1 0 Biological 19 -1.4707 2.76701 2.42188 24156 50 873 5 0.572738 0.255402 -0.33951 0 0 46 proliferation 034|8016 A|PDGFC| Processes 9 CTC1 10403|51 NDC80|N GO GO:00516 203|5482 USAP1|N 1 -1.4707 M1 1 0 Biological 19 spindle localization -1.4707 2.76701 2.42188 24156 50 873 5 0.572738 0.255402 -0.33951 0 0 53 0|79648|2 DE1|MCP Processes 59266 H1|ASPM COMT|M 1312|420 GO EF2C|NPR GO:00486 negative regulation of smooth muscle cell 8|4883|49 1 -1.47026 M1 1 0 Biological 19 -1.47026 2.47792 2.345687 24156 67 873 6 0.687285 0.279617 3|OGN|PP -0.33951 0 0 62 proliferation 69|10891| Processes ARGC1A| 93649 MYOCD 7057|102 THBS1|RA GO 66|28984| MP2|RGC GO:00725 1 -1.47026 M1 1 0 Biological 19 endothelial cell apoptotic process -1.47026 2.47792 2.345687 24156 67 873 6 0.687285 0.279617 51129|19 C|ANGPT -0.33951 0 0 77 Processes 6527|641 L4|ANO6| 700 ECSCR GO 54464|80 GO:00322 negative regulation of telomere XRN1|PIF 1 -1.46969 M1 1 0 Biological 19 -1.46969 4.150515 2.729324 24156 20 873 3 0.343643 0.198061 119|8016 -0.33951 0 0 11 maintenance via telomerase 1|CTC1 Processes 9 332|699|7 BIRC5|BU 01|1062|1 B1|BUB1B 063|2491| |CENPE|C 4751|499 ENPF|CE 9|7272|86 NPI|NEK2 55|10403| |ORC2|TT 11004|23 K|DYNLL1 GO 421|2708 |NDC80|K GO:00007 Cellular 1 -10.7245 M1 1 0 20 kinetochore -10.7245 5.086416 9.253727 24156 136 873 25 2.863688 0.564477 5|54820|5 IF2C|ITGB -7.81809 0 2 0 0 -22.074 10.54099 76 Compone 4821|553 3BP|MTB nts 55|55839| P|NDE1|E 56155|57 RCC6L|HJ 082|5740 URP|CEN 5|79003|8 PN|TEX14 1930|835 |KNL1|SP 40|22115 C25|MIS1 0 2|KIF18A| BIRC5|BU 332|699|7 B1|BUB1B 01|983|10 |CDK1|CE 62|1063|2 NPE|CEN 491|8655| PF|CENPI| 9133|104 DYNLL1|C 03|11004| CNB2|ND 23421|54 C80|KIF2 R-HSA- Reactome 820|5482 C|ITGB3B 1 -10.6626 M1 1 0 6 Resolution of Sister Chromatid Cohesion -10.6626 5.270496 9.306317 24156 126 873 24 2.749141 0.553399 -7.76879 0 2 0 0 -22.074 10.54099 2500257 Gene Sets 1|55839|5 P|NDE1|E 7082|574 RCC6L|CE 05|79003| NPN|KNL 79861|81 1|SPC25| 027|8193 MIS12|TU 0|83540|9 BAL3|TUB 1687|401 B1|KIF18A 541 |NUF2|CE NPL|CEN BIRC5|BA RD1|BRC 332|580|6 A1|BUB1| 72|699|70 BUB1B|C 1|983|106 DK1|CEN 2|1063|24 PE|CENPF 91|4175|4 |CENPI|M 361|4998| CM6|MRE 4999|746 11|ORC1| 5|8317|83 ORC2|WE 18|8655|9 E1|CDC7| 133|9134| CDC45|D 9156|104 YNLL1|CC R-HSA- Reactome 1 -10.3968 M1 1 0 6 Cell Cycle Checkpoints -10.3968 3.494177 8.317441 24156 293 873 37 4.238259 0.68184 03|11004| NB2|CCN -7.51522 0 2 0 0 -22.074 10.54099 69620 Gene Sets 23421|51 E2|EXO1| 512|5482 NDC80|KI 0|54821|5 F2C|ITGB 5388|558 3BP|GTSE 39|57082| 1|NDE1|E 57405|63 RCC6L|M 967|7900 CM10|CE 3|80010|8 NPN|KNL 1930|835 1|SPC25| 40|91687| CLSPN|MI 401541 S12|RMI1| KIF18A|N UF2|CEN GO 10736|51 GO:00424 SIX2|INSI 1 -1.46969 M1 1 0 Biological 19 middle ear morphogenesis -1.46969 4.150515 2.729324 24156 20 873 3 0.343643 0.198061 141|1160 -0.33951 0 0 74 G2|OSR2 Processes 39 GO GO:00602 3976|693 LIF|TCF15 1 -1.46969 M1 1 0 Biological 19 mesenchymal to epithelial transition -1.46969 4.150515 2.729324 24156 20 873 3 0.343643 0.198061 -0.33951 0 0 31 9|10736 |SIX2 Processes GO GO:00720 3976|107 LIF|SIX2|S 1 -1.46969 M1 1 0 Biological 19 renal vesicle development -1.46969 4.150515 2.729324 24156 20 873 3 0.343643 0.198061 -0.33951 0 0 87 36|30812 OX8 Processes 4089|530 SMAD4|PI GO 8|6422|64 TX2|SFRP GO:00097 1 -1.4671 M1 1 0 Biological 19 axis specification -1.4671 2.278714 2.286794 24156 85 873 7 0.801833 0.301847 91|6790|1 1|STIL|AU -0.3382 0 0 98 Processes 0736|441 RKA|SIX2| 478 NRARP 983|1385| CDK1|CR GO 2247|420 EB1|FGF2| GO:00458 positive regulation of striated muscle tissue 1 -1.4671 M1 1 0 Biological 19 -1.4671 2.278714 2.286794 24156 85 873 7 0.801833 0.301847 8|10413|2 MEF2C|Y -0.3382 0 0 44 development Processes 3414|936 AP1|ZFP 49 M2|MYO 672|675|7 BRCA1|BR 01|899|98 CA2|BUB 3|1021|10 1B|CCNF| 63|3161|4 CDK1|CD 089|4751| K6|CENPF 4999|511 |HMMR|S 6|5420|60 MAD4|NE 17|6491|6 K2|ORC2| 790|7153| PCNT|PO 8318|865 DXL|RLBP 5|9133|91 1|STIL|AU 34|9493|9 RKA|TOP 585|9645| 2A|CDC4 GO 9662|978 5|DYNLL1 GO:00058 Cellular 1 -10.0997 M1 1 0 20 microtubule organizing center -10.0997 2.374807 7.50255 24156 769 873 66 7.560137 0.89472 7|9814|10 |CCNB2|C -7.28503 0 12 1 1 -10.0997 6.06468 15 Compone 403|1046 CNE2|KIF nts 0|10733|1 23|KIF20B 1004|111 |MICAL2| 04|25886| CEP135|D 26586|28 LGAP5|SF 984|5109 I1|NDC80 8|51514|5 |TACC3|P 1715|548 LK4|KIF2C 20|55112| |KATNA1| 55125|55 POC1A|C 137|5516 KAP2|RG 5|55171|5 CC|IFT52| 5196|558 DTL|RAB2 35|56890| 3|NDE1| 675|899|9 BRCA2|C 83|1021|1 CNF|CDK 063|3161| 1|CDK6|C 4089|475 ENPF|HM 1|4999|51 MR|SMA 16|5420|6 D4|NEK2| 017|6491| ORC2|PC 6790|831 NT|PODX 8|8655|91 L|RLBP1|S 33|9134|9 TIL|AURK 493|9585| A|CDC45| 9662|978 DYNLL1|C 7|9814|10 CNB2|CC GO 403|1046 NE2|KIF2 GO:00058 Cellular 1 -10.059 M1 1 0 20 centrosome -10.059 2.619373 7.650684 24156 581 873 55 6.300115 0.822312 0|10733|1 3|KIF20B| -7.25455 0 12 0 0 -10.0997 6.06468 13 Compone 1004|111 CEP135|D nts 04|25886| LGAP5|SF 26586|28 I1|NDC80 984|5109 |TACC3|P 8|51514|5 LK4|KIF2C 1715|548 |KATNA1| 20|55112| POC1A|C 55125|55 KAP2|RG 165|5517 CC|IFT52| 1|55835|5 DTL|RAB2 6890|794 3|NDE1| 41|79444| WDR60|C 80184|84 EP192|CE 318|8493 P55|TBCC CREB1|HT 1385|335 R2B|TNFR GO 7|7132|91 GO:00468 positive regulation of lipid biosynthetic SF1A|RG 1 -1.4671 M1 1 0 Biological 19 -1.4671 2.278714 2.286794 24156 85 873 7 0.801833 0.301847 04|10891| -0.3382 0 0 89 process N|PPARG Processes 85414|15 C1A|SLC4 7506 5A3|RDH CCN2|DP 1490|180 T|FBLN2|F 5|2199|22 BN1|FBN 00|2201|2 2|FN1|LA 335|3909| MA3|LAM 3914|405 B3|LTBP1| 2|4053|42 LTBP2|MF 37|7057|7 AP2|THBS 058|7130| 1|THBS2| 8483|942 TNFAIP6| Canonical 3|10516|1 CILP|NTN 1 -9.92705 M3008 M1 1 0 11 NABA ECM GLYCOPROTEINS -9.92705 4.094046 8.421754 24156 196 873 29 3.321879 0.606525 -7.15192 0 1 0 0 -22.6822 5.869416 Pathways 0631|258 1|FBLN5|P 78|64129| OSTN|MX 79812|83 RA5|TINA 872|8446 GL1|MMR 7|84624|1 N2|HMC 33584|13 N1|FBN3| 7902|284 FNDC1|E 217|3404 GFLAM|P 19|34203 XDNL|LA 5 MA1|RSP O2|GLDN 983|1385| CDK1|CR GO 2247|420 EB1|FGF2| GO:00486 positive regulation of muscle organ 1 -1.4671 M1 1 0 Biological 19 -1.4671 2.278714 2.286794 24156 85 873 7 0.801833 0.301847 8|10413|2 MEF2C|Y -0.3382 0 0 36 development Processes 3414|936 AP1|ZFP 49 M2|MYO 983|2247| CDK1|FGF GO 4208|560 2|MEF2C| GO:00604 1 -1.4671 M1 1 0 Biological 19 regulation of heart growth -1.4671 2.278714 2.286794 24156 85 873 7 0.801833 0.301847 0|5629|10 MAPK11| -0.3382 0 0 20 Processes 413|2341 PROX1|Y 4 AP1|ZFP CHRM3|D 1131|181 GO RD5|EDN GO:00977 negative regulation of blood vessel 6|1907|19 1 -1.4671 M1 1 0 Biological 19 -1.4671 2.278714 2.286794 24156 85 873 7 0.801833 0.301847 2|EDN3|H -0.3382 0 0 56 diameter 08|3269|3 Processes RH1|HTR 357|6915 2B|TBXA2 ACTN2|C 88|1393|2 RHBP|ST 040|2048| OM|EPHB 2273|289 2|FHL1|G 0|2902|42 RIA1|GRI GO 08|5174|9 N1|MEF2 GO:00324 1 -1.46428 M1 1 0 Biological 19 regulation of transporter activity -1.46428 1.627653 2.078552 24156 289 873 17 1.947308 0.467671 104|1036 C|PDZK1| -0.3358 0 0 09 Processes 9|10891|2 RGN|CAC 2871|232 NG2|PPA 37|54997| RGC1A|N 126755|7 LGN1|AR 29230 C|TESC|LR RC38|CCR BIRC5|BU 332|699|7 B1|BUB1B 01|1062|1 |CENPE|C 063|2491| ENPF|CE 8655|104 NPI|DYNL 03|11004| L1|NDC80 23421|54 |KIF2C|IT R-HSA- Reactome Amplification of signal from the 1 -9.72529 M1 1 0 6 -9.72529 5.764605 9.057448 24156 96 873 20 2.290951 0.50637 820|5482 GB3BP|N -6.99497 0 2 0 0 -22.074 10.54099 141424 Gene Sets kinetochores 1|55839|5 DE1|ERCC 7082|574 6L|CENP 05|79003| N|KNL1|S 81930|83 PC25|MIS 540|9168 12|KIF18A 7|401541 |NUF2|CE NPL|CEN BIRC5|BU 332|699|7 B1|BUB1B 01|1062|1 |CENPE|C 063|2491| ENPF|CE 8655|104 NPI|DYNL 03|11004| L1|NDC80 23421|54 |KIF2C|IT R-HSA- Reactome Amplification of signal from unattached 1 -9.72529 M1 1 0 6 -9.72529 5.764605 9.057448 24156 96 873 20 2.290951 0.50637 820|5482 GB3BP|N -6.99497 0 2 0 0 -22.074 10.54099 141444 Gene Sets kinetochores via a MAD2 inhibitory signal 1|55839|5 DE1|ERCC 7082|574 6L|CENP 05|79003| N|KNL1|S 81930|83 PC25|MIS 540|9168 12|KIF18A 7|401541 |NUF2|CE NPL|CEN BIRC5|BU 332|699|7 B1|BUB1B 01|1062|1 |CENPE|C 063|2491| ENPF|CE 8655|104 NPI|DYNL 03|11004| L1|NDC80 23421|54 |KIF2C|IT 820|5482 GB3BP|N R-HSA- Reactome EML4 and NUDC in mitotic spindle 1 -9.71539 M1 1 0 6 -9.71539 5.202925 8.824246 24156 117 873 22 2.520046 0.530463 1|55839|5 DE1|ERCC -6.9935 0 2 0 0 -22.074 10.54099 9648025 Gene Sets formation 7082|574 6L|CENP 05|79003| N|KNL1|S 79861|81 PC25|MIS 027|8193 12|TUBAL 0|83540|9 3|TUBB1| 1687|401 KIF18A|N 541 UF2|CEN PL|CENPP BRCA1|BR 672|675|8 CA2|CAS 35|1545|1 P2|CYP1B 870|3090| 1|E2F2|HI 5366|638 C1|PMAIP GO 7|6498|71 1|CXCL12 GO:00971 1 -1.46428 M1 1 0 Biological 19 intrinsic apoptotic signaling pathway -1.46428 1.627653 2.078552 24156 289 873 17 1.947308 0.467671 32|7133|9 |SKIL|TNF -0.3358 0 0 93 Processes 833|3000 RSF1A|TN 1|53832|5 FRSF1B|M 5031|904 ELK|ERO1 27|21979 A|IL20RA| 0 USP47|B MF|RTKN BIRC5|BU 332|699|7 B1|BUB1B 01|1062|1 |CENPE|C 063|4751| ENPF|NEK 4999|679 2|ORC2|A 0|10403|1 URKA|ND 1004|234 GO C80|KIF2 21|54820| GO:00007 Cellular condensed chromosome, centromeric C|ITGB3B 1 -9.49359 M1 1 0 20 -9.49359 5.072852 8.660627 24156 120 873 22 2.520046 0.530463 54821|55 -6.78809 0 2 0 0 -22.074 10.54099 79 Compone region P|NDE1|E 355|5583 nts RCC6L|HJ 9|56155|5 URP|CEN 7082|574 PN|TEX14 05|64151| |KNL1|SP 79003|83 C25|NCA 540|2211 PG|MIS12 50 |NUF2|SK AGTR2|C 186|947|1 D34|DRD 816|1907| 5|EDN2|E GO 1908|488 DN3|NPR GO:00082 1 -1.46381 M1 1 0 Biological 19 regulation of blood pressure -1.46381 1.814433 2.141465 24156 183 873 12 1.37457 0.394068 3|4886|51 3|NPY1R| -0.33554 0 0 17 Processes 25|5742|6 PCSK5|PT 915|1026 GS1|TBXA 6|10631 2R|RAMP 2|POSTN HES1|ITG 3280|367 A2|LIF|NE 3|3976|47 GO K2|PAX7| GO:00511 51|5081|5 1 -1.46194 M1 1 0 Biological 19 regulation of DNA binding -1.46194 2.024642 2.206032 24156 123 873 9 1.030928 0.341867 HJURP|M -0.33432 0 0 01 5355|936 Processes YOCD|WF 49|11716 IKKN1|WF 6|124857 IKKN2 COL4A5| COL4A6| COL5A1| 1287|128 COL7A1| 8|1289|12 COL8A1| 94|1295|1 COL9A3| 299|1306| COL15A1| 3691|390 ITGB4|LA R-HSA- Reactome 9|3914|40 1 -9.37583 M1 1 0 6 Collagen formation -9.37583 5.841466 8.910198 24156 90 873 19 2.176403 0.493838 MA3|LAM -6.69381 0 5 0 0 -15.2617 12.29782 1474290 Gene Sets 17|4316|7 B3|LOXL2 093|9508| |MMP7|TL 10491|55 L2|ADAM 214|8457 TS3|CRTA 0|131873| P|P3H2|C 136227 OL25A1|C OL6A6|C OL26A1 COL4A5| COL4A6| 1287|128 COL5A1| 8|1289|12 COL7A1| 94|1295|1 COL8A1| GO 306|2200| COL15A1| GO:00444 Cellular 1 -9.3164 M1 1 0 20 extracellular matrix component -9.3164 7.68614 9.524385 24156 54 873 15 1.718213 0.439813 2201|390 FBN1|FBN -6.64193 0 5 0 0 -15.2617 12.29782 20 Compone 9|3914|40 2|LAMA3| nts 52|4060|4 LAMB3|LT 237|1051 BP1|LUM| 6|284217 MFAP2|F BLN5|LA MA1 STOM|EP 2040|204 HB2|LGAL 8|3958|51 S3|PDZK1 GO GO:19054 positive regulation of protein localization to 74|5366|7 |PMAIP1| 1 -1.46194 M1 1 0 Biological 19 -1.46194 2.024642 2.206032 24156 123 873 9 1.030928 0.341867 -0.33432 0 0 77 membrane 029|1036 TFDP2|CA Processes 9|84455|8 CNG2|EF 4687 CAB7|PPP 1R9B AGTR2|C D34|FN1| 186|947|2 HTR2B|M 335|3357| BP|MAPK 4155|560 11|TNFRS GO 0|7133|87 GO:00507 F1B|RIPK2 1 -1.45963 M1 1 0 Biological 19 regulation of cytokine secretion -1.45963 1.721695 2.105988 24156 225 873 14 1.603666 0.425147 67|10125| -0.33222 0 0 07 |RASGRP1 Processes 10631|28 |POSTN|R 984|7967 GCC|VTC 9|114899| N1|C1QT 131450 NF3|CD2 00R1 BIRC5|BU 332|701|9 B1B|CDK1 83|1062|1 |CENPE|C 063|1894| ENPF|ECT 3832|475 2|KIF11|N 1|6790|70 EK2|AURK 29|7272|8 A|TFDP2| 317|8655| TTK|CDC7 9493|958 |DYNLL1| 5|9587|97 KIF23|KIF 87|9928|1 20B|MAD 0460|107 2L1BP|DL GO 33|11004| GAP5|KIF GO:00058 Cellular 11104|22 14|TACC3 1 -9.00258 M1 1 0 20 spindle -9.00258 3.014341 7.435247 24156 358 873 39 4.467354 0.699188 -6.35001 0 8 0 0 -11.3911 5.158833 19 Compone 974|2413 |PLK4|KIF nts 7|25886|2 2C|KATN 6586|512 A1|TPX2| 03|54820| KIF4A|PO 55112|55 C1A|CKA 171|5518 P2|NUSA 3|79441|7 P1|NDE1| 9866|819 WDR60|T 30|85459| BCCD1|RI 121441|1 F1|HAUS3 26731|22 |BORA|KIF 1150|259 18A|CEP2 266 95|NEDD 1|CCSAP| BIRC5|BU 332|699|7 B1|BUB1B 01|1062|1 |CENPE|C 063|4751| ENPF|NEK 4999|104 2|ORC2|N 03|11004| GO DC80|KIF 23421|54 GO:00007 Cellular 2C|ITGB3 1 -8.91933 M1 1 0 20 condensed chromosome kinetochore -8.91933 5.220774 8.432934 24156 106 873 20 2.290951 0.50637 820|5482 -6.27383 0 2 0 0 -22.074 10.54099 77 Compone BP|NDE1| 1|55355|5 nts ERCC6L|H 5839|561 JURP|CEN 55|57082| PN|TEX14 57405|79 |KNL1|SP 003|8354 C25|MIS1 0|221150 2|NUF2|S 1490|423 CCN2|ME 3|6422|11 T|SFRP1|S GO GO:00322 regulation of actin filament bundle 346|2284 YNPO|PP 1 -1.4582 M1 1 0 Biological 19 -1.4582 2.128469 2.233171 24156 104 873 8 0.91638 0.322501 -0.331 0 0 31 assembly 3|22998|2 M1E|LIM Processes 8984|849 CH1|RGC 52 C|CGNL1 ADORA2 A|AGTR2| 135|186|2 SLC25A4| 91|1385|1 CREB1|CR 393|1908| HBP|EDN 3624|397 GO 3|INHBA| GO:00468 6|4089|64 1 -1.44356 M1 1 0 Biological 19 regulation of hormone secretion -1.44356 1.645805 2.062473 24156 269 873 16 1.832761 0.453972 LIF|SMAD -0.318 0 0 83 22|7074|8 Processes 4|SFRP1|T 111|9324| IAM1|GP 23178|94 R68|HMG 121|1148 N3|PASK| 99 SYTL4|C1 QTNF3 GAS1|EN 2619|516 PP1|SERPI GO 7|5270|59 GO:00085 regulation of smoothened signaling NE2|RFX4 1 -1.4434 M1 1 0 Biological 19 -1.4434 2.252218 2.25259 24156 86 873 7 0.801833 0.301847 92|6095|6 -0.318 0 0 89 pathway |RORA|SF Processes 422|2226 RP1|SCUB 63 E3 238|699|7 ALK|BUB1 01|815|89 |BUB1B|C 4|899|901 AMK2A|C |983|1021 CND2|CC |2047|204 NF|CCNG 8|2324|37 2|CDK1|C 06|4052|4 DK6|EPH 214|4233| B1|EPHB2 4751|491 |FLT4|ITP 6|5156|55 KA|LTBP1| 63|5587|5 MAP3K1| 593|5600| MET|NEK 5891|650 2|NTRK3| GO 3|6790|70 PDGFRA| GO:00046 1 -8.49261 M1 1 0 Molecular 21 protein kinase activity -8.49261 2.419993 6.855168 24156 606 873 53 6.071019 0.808209 75|7272|7 PRKAA2|P -5.87426 0 16 1 1 -8.49261 2.419993 72 Functions 465|8317| RKD1|PRK 8767|913 G2|MAPK 3|9134|98 11|MOK|S 33|10733| LA|AURK 23178|29 A|TIE1|TT 941|5390 K|WEE1|C 4|54757|5 DC7|RIPK 5359|561 2|CCNB2| 55|57172| CCNE2|M 57538|79 ELK|PLK4| 675|8178 PASK|PK 8|84687|8 N3|MYO3 4930|854 A|FAM20 17|91461| A|STYK1|T BIRC5|BU 332|699|7 B1|BUB1B 01|1062|1 |CENPE|C 063|2491| ENPF|CE 8655|104 NPI|DYNL 03|11004| L1|NDC80 23421|54 |KIF2C|IT R-HSA- Reactome 1 -8.48242 M1 1 0 6 Mitotic Spindle Checkpoint -8.48242 4.94109 8.094931 24156 112 873 20 2.290951 0.50637 820|5482 GB3BP|N -5.87061 0 2 0 0 -22.074 10.54099 69618 Gene Sets 1|55839|5 DE1|ERCC 7082|574 6L|CENP 05|79003| N|KNL1|S 81930|83 PC25|MIS 540|9168 12|KIF18A 7|401541 |NUF2|CE NPL|CEN 2840|284 GPR17|LP GO 6|10125|1 AR4|RAS GO:00465 positive regulation of Ras protein signal 1 -1.44308 M1 1 0 Biological 19 -1.44308 2.44148 2.304909 24156 68 873 6 0.687285 0.279617 0276|506 GRP1|NE -0.318 0 0 79 transduction Processes 50|15728 T1|ARHG 5 EF3|PRAG 87|88|794 ACTN1|A |1003|100 CTN2|CA 5|1007|10 LB2|CDH5 08|1009|1 |CDH7|CD 462|2199| H9|CDH1 2200|220 0|CDH11| 1|2902|30 VCAN|FB 26|4017|4 LN2|FBN1 052|4053| |FBN2|GRI 4632|512 N1|HABP 1|5167|51 2|LOXL2|L 69|5321|7 TBP1|LTB 056|7057| P2|MYL1| GO 7058|709 PCP4|ENP GO:00055 1 -8.2583 M1 1 0 Molecular 21 calcium ion binding -8.2583 2.276406 6.6603 24156 705 873 58 6.643757 0.842891 3|7139|71 P1|ENPP3 -5.65926 0 17 1 1 -8.2583 2.276406 09 Functions 40|9104|9 |PLA2G4A 833|1012 |THBD|TH 5|10516|1 BS1|THBS 0590|229 2|TLL2|TN 18|23213| NT2|TNN 25780|25 T3|RGN| 975|5129 MELK|RA 4|54567|5 SGRP1|FB 4997|557 LN5|SCG 84|56884| N|CD93|S 57526|63 ULF1|RAS 941|6407 GRP3|EGF 2|64123|6 L6|PCDH1 4800|648 2|DLL4|TE CDK1|HM 983|3161| MR|NEK2| 4751|511 PCNT|AU 6|6790|86 RKA|DYN 55|9662|9 LL1|CEP1 814|1073 R-HSA- Reactome 35|SFI1|PL 1 -8.24723 M1 1 0 6 AURKA Activation by TPX2 -8.24723 6.06468 8.391688 24156 73 873 16 1.832761 0.453972 3|22974|5 -5.65572 0 12 0 0 -10.0997 6.06468 8854518 Gene Sets K4|TPX2| 4820|551 NDE1|CE 25|55835| P192|CEN 79441|80 PJ|HAUS3 184|1214 |CEP290| 41 NEDD1 CDK1|FGF 983|2247| GO 2|MEF2C| GO:00600 4208|560 1 -1.44308 M1 1 0 Biological 19 cardiac muscle cell proliferation -1.44308 2.44148 2.304909 24156 68 873 6 0.687285 0.279617 MAPK11| -0.318 0 0 38 0|10413|2 Processes YAP1|ZFP 3414 M2 BIRC5|BU 332|699|7 B1|BUB1B 01|1062|1 |CENPE|C 063|2491| ENPF|CE 8655|104 NPI|DYNL 03|11004| L1|NDC80 23421|54 |KIF2C|IT 820|5482 GB3BP|N R-HSA- Reactome 1 -8.18294 M1 1 0 6 RHO GTPases Activate Formins -8.18294 4.348159 7.693269 24156 140 873 22 2.520046 0.530463 1|55839|5 DE1|ERCC -5.60837 0 2 0 0 -22.074 10.54099 5663220 Gene Sets 7082|574 6L|CENP 05|79003| N|KNL1|S 79861|81 PC25|MIS 027|8193 12|TUBAL 0|83540|9 3|TUBB1| 1687|401 KIF18A|N 541 UF2|CEN PL|CENPP COL4A5| COL4A6| 1287|128 COL5A1| 8|1289|12 COL7A1| 94|1295|1 COL8A1| 299|1306| COL9A3| 2200|220 COL15A1| 1|2335|39 FBN1|FBN 09|3914|4 2|FN1|LA R-HSA- Reactome 1 -8.18294 M1 1 0 6 Degradation of the extracellular matrix -8.18294 4.348159 7.693269 24156 140 873 22 2.520046 0.530463 312|4316| MA3|LAM -5.60837 0 5 0 0 -15.2617 12.29782 1474228 Gene Sets 7093|844 B3|MMP1 67|84570| |MMP7|TL 131873|1 L2|FBN3| 36227|17 COL25A1| 0692|222 COL6A6| 663|4408 COL26A1| 54 ADAMTS 18|SCUBE 3|CAPN1 3976|104 LIF|YAP1| GO GO:00604 13|15750 RDH10|L 1 -1.4385 M1 1 0 Biological 19 lung morphogenesis -1.4385 2.712755 2.370926 24156 51 873 5 0.572738 0.255402 -0.31514 0 0 25 6|284217| AMA1|RS Processes 340419 PO2 FZD2|HES GO 2535|328 GO:00901 1|NTRK3| 1 -1.4385 M1 1 0 Biological 19 cochlea development -1.4385 2.712755 2.370926 24156 51 873 5 0.572738 0.255402 0|4916|69 -0.31514 0 0 02 ZEB1|MY Processes 35|53904 O3A NDC80|N GO 10403|51 GO:00400 USAP1|N 1 -1.43748 M1 1 0 Biological 19 establishment of mitotic spindle localization -1.43748 3.162297 2.478809 24156 35 873 4 0.45819 0.22857 203|5482 -0.31514 0 0 01 DE1|MCP Processes 0|79648 H1 CRHBP|T GO 1393|705 GO:00713 H|PPARG 1 -1.43748 M1 1 0 Biological 19 cellular response to alkaloid -1.43748 3.162297 2.478809 24156 35 873 4 0.45819 0.22857 4|10891|8 -0.31514 0 0 12 C1A|PPP1 Processes 4687 R9B GO 894|1164| CCND2|C GO:19040 positive regulation of cyclin-dependent 1 -1.43748 M1 1 0 Biological 19 -1.43748 3.162297 2.478809 24156 35 873 4 0.45819 0.22857 5629|289 KS2|PROX -0.31514 0 0 31 protein kinase activity Processes 84 1|RGCC CDK1|CE 983|1062| NPE|ECT2 1894|383 |KIF11|AU 2|6790|70 RKA|TFDP 29|8317|8 2|CDC7|D 655|9493| YNLL1|KIF GO 9585|104 23|KIF20B GO:00726 Cellular 60|11104| 1 -7.75714 M1 1 0 20 mitotic spindle -7.75714 4.499204 7.533711 24156 123 873 20 2.290951 0.50637 |TACC3|K -5.21688 0 8 0 0 -11.3911 5.158833 86 Compone 22974|51 ATNA1|T nts 203|7944 PX2|NUS 1|81930|8 AP1|HAU 5459|126 S3|KIF18A 731|2211 |CEP295| 50|25926 CCSAP|SK 6 A3|ASPM CENPI|RB 2491|593 BP7|CHAF 1|8208|83 1B|H3C10 57|23421| |ITGB3BP| GO 55355|55 GO:00347 HJURP|M 1 -1.43311 M1 1 0 Biological 19 nucleosome organization -1.43311 1.794817 2.101364 24156 185 873 12 1.37457 0.394068 506|5583 -0.31119 0 0 28 ACROH2 Processes 9|57082|9 A2|CENP 1687|401 N|KNL1|C 541|6536 ENPL|CE 04 NPP|H3C ADORA2 A|ADORA 135|136|1 2B|CHRM 131|1395| 3|CRHR2| 1816|291 DRD5|GR GO 3|4161|48 GO:00071 adenylate cyclase-modulating G protein- M3|MC5R 1 -1.43224 M1 1 0 Biological 19 -1.43224 1.706526 2.070952 24156 227 873 14 1.603666 0.425147 83|4886|5 -0.31052 0 0 88 coupled receptor signaling pathway |NPR3|NP Processes 744|6915| Y1R|PTHL 10149|10 H|TBXA2 266|6412 R|ADGRG 3 2|RAMP2| ADGRL4 BUB1|BU B1B|CCN 699|701|8 D2|CDK1| 94|983|10 CDK6|CD 21|1030|1 KN2B|E2F 870|4089| 2|SMAD4| 4175|499 KEGG MCM6|O 1 -7.69554 hsa04110 M1 1 0 24 Cell cycle -7.69554 4.46292 7.485994 24156 124 873 20 2.290951 0.50637 8|4999|70 -5.17312 0 20 1 1 -7.69554 7.546392 Pathway RC1|ORC 29|7272|7 2|TFDP2|T 465|8317| TK|WEE1| 8318|913 CDC7|CD 3|9134|92 C45|CCN 32|85417 B2|CCNE 2|PTTG1| 1062|383 CENPE|KI GO 2|9493|11 F11|KIF23 GO:00068 retrograde vesicle-mediated transport, 1 -1.42014 M1 1 0 Biological 19 -1.42014 2.22633 2.218856 24156 87 873 7 0.801833 0.301847 004|2413 |KIF2C|KIF -0.29981 0 0 90 Golgi to ER Processes 7|26153|8 4A|KIF26 1930 A|KIF18A ESRRB|EN 2103|516 PP1|HS2S GO GO:00336 7|9653|23 T1|PASK| 1 -1.41649 M1 1 0 Biological 19 cellular polysaccharide biosynthetic process -1.41649 2.406096 2.264849 24156 69 873 6 0.687285 0.279617 -0.29981 0 0 92 178|5579 CSGALNA Processes 0|93010 CT1|B3G NT7 655|1393| BMP7|CR 2239|224 HBP|GPC 7|2277|30 4|FGF2|VE 26|3263|3 GFD|HAB 624|3958| P2|HPX|I 3976|401 NHBA|LG 7|4312|43 ALS3|LIF|L 16|4902|5 OXL2|MM 125|5228| P1|MMP7 5270|638 |NRTN|PC 7|6422|64 SK5|PGF|S 25|7078|7 ERPINE2| 079|7093| CXCL12|S 8492|874 FRP1|SFR Canonical 1 -7.62485 M5885 M1 1 0 11 NABA MATRISOME ASSOCIATED -7.62485 2.168043 6.305385 24156 753 873 59 6.758305 0.849605 3|9508|95 P5|TIMP3| -5.11637 0 21 1 1 -7.62485 2.171781 Pathways 47|9719|9 TIMP4|TL 723|9966| L2|PRSS1 10468|11 2|TNFSF1 174|2321 0|ADAMT 3|25975|5 S3|CXCL1 1129|544 4|ADAMT 37|54757| SL2|SEMA 55214|56 3E|TNFSF 034|5718 15|FST|A 8|64066|7 DAMTS6| 9148|803 SULF1|EG 26|80760| FL6|ANGP 91851|11 TL4|SEMA 4899|117 5B|FAM2 CREB1|NT 1385|491 GO RK3|ALD GO:00713 6|8854|10 1 -1.41649 M1 1 0 Biological 19 cellular response to retinoic acid -1.41649 2.406096 2.264849 24156 69 873 6 0.687285 0.279617 H1A2|YA -0.29981 0 0 00 413|5499 Processes P1|TESC|B 7|339479 RINP3 6915|705 TBXA2R|T GO 6|7057|78 HBD|THB GO:00903 1 -1.41649 M1 1 0 Biological 19 positive regulation of wound healing -1.41649 2.406096 2.264849 24156 69 873 6 0.687285 0.279617 52|19652 S1|CXCR4 -0.29981 0 0 03 Processes 7|100506 |ANO6|O 658 CLN COL4A5| COL4A6| 1287|128 COL5A1| 8|1289|12 COL7A1| 94|1295|1 COL8A1| 299|1306| COL9A3| R-HSA- Reactome Assembly of collagen fibrils and other 1 -7.56696 M1 1 0 6 -7.56696 6.350515 8.101926 24156 61 873 14 1.603666 0.425147 3691|390 COL15A1| -5.07355 0 5 0 0 -15.2617 12.29782 2022090 Gene Sets multimeric structures 9|3914|40 ITGB4|LA 17|4316|7 MA3|LAM 093|1318 B3|LOXL2 73 |MMP7|TL L2|COL6A 6 BMP7|CO L5A1|VCA 655|1289| N|CCN2|F 1462|149 BN1|FGF2 0|2200|22 |FN1|HAB 47|2335|3 P2|CFH|H 026|3075| MMR|LTB 3161|405 P2|MMP7 3|4316|52 |PGF|SER 28|5270|6 GO PINE2|SF GO:00055 422|7057| 1 -7.55129 M1 1 0 Molecular 21 glycosaminoglycan binding -7.55129 3.325163 6.90581 24156 233 873 28 3.207331 0.596329 RP1|THBS -5.06278 0 22 1 1 -7.55129 3.438297 39 7058|713 Functions 1|THBS2| 0|9388|95 TNFAIP6| 08|10631| LIPG|ADA 23213|84 MTS3|PO 570|1335 STN|SULF 84|14586 1|COL25A 4|149998| 1|EGFLA 151887|3 M|HAPLN 40419 3|LIPI|CC DC80|RSP 2247|475 FGF2|NEK GO GO:20005 positive regulation of DNA biosynthetic 1|5073|75 2|PARN|X 1 -1.41649 M1 1 0 Biological 19 -1.41649 2.406096 2.264849 24156 69 873 6 0.687285 0.279617 -0.29981 0 0 73 process 20|28984| RCC5|RG Processes 79075 CC|DSCC AGTR2|C 186|947|1 D34|CHA GO 103|1545| GO:00421 T|CYP1B1 1 -1.41643 M1 1 0 Biological 19 neurotransmitter biosynthetic process -1.41643 2.08831 2.174398 24156 106 873 8 0.91638 0.322501 6095|705 -0.29981 0 0 36 |RORA|TH Processes 4|9104|26 |RGN|MO 002 XD1 COL4A5| 1287|128 COL4A6| 8|1299|23 COL9A3|F 35|2814|3 N1|GP5|H 161|3672| MMR|ITG KEGG 3673|369 A1|ITGA2| 1 -7.4807 hsa04512 M1 1 0 24 ECM-receptor interaction -7.4807 5.399045 7.726491 24156 82 873 16 1.832761 0.453972 -5.0066 0 23 1 1 -7.4807 8.301031 Pathway 0|3691|39 ITGB3|ITG 09|3914|7 B4|LAMA 057|7058| 3|LAMB3| 131873|2 THBS1|TH 84217 BS2|COL6 A6|LAMA ADORA2 B|AGTR2| BRCA1|C 136|186|6 D34|CMK 72|947|12 LR1|CREB 40|1385|1 1|CYP1B1 545|2324| |FLT4|FN1 2335|335 |HTR2B|I 7|3624|40 NHBA|LT 52|4060|4 BP1|LUM| 089|4155| SMAD4| 4361|560 MBP|MRE 0|5795|60 11|MAPK GO 95|7057|7 GO:00018 11|PTPRJ| 1 -1.41471 M1 1 0 Biological 19 regulation of cytokine production -1.41471 1.356018 1.924508 24156 755 873 37 4.238259 0.68184 133|7520| -0.29981 0 0 17 RORA|TH Processes 8767|877 BS1|TNFR 2|9865|10 SF1B|XRC 125|1029 C5|RIPK2| 3|10631|2 FADD|TRI 3213|289 L|RASGRP 84|51284| 1|TRAIP|P 56244|79 OSTN|SU 679|1148 LF1|RGCC 99|13145 |TLR7|BT 0|147372| NL2|VTC 729230 N1|C1QT NF3|CD2 00R1|CCB BMP7|FBL 655|2199| N2|FBN1| 2200|220 FBN2|FN1 1|2335|36 R-HSA- Reactome |ITGB3|LO 1 -7.35548 M1 1 0 6 Elastic fibre formation -7.35548 7.378694 8.29319 24156 45 873 12 1.37457 0.394068 90|4017|4 -4.89072 0 24 1 1 -7.35548 20.75258 1566948 Gene Sets XL2|LTBP 052|4053| 1|LTBP2| 4237|105 MFAP2|F 16|84467 BLN5|FBN 238|699|7 ALK|BUB1 01|815|89 |BUB1B|C 4|899|901 AMK2A|C |983|1021 CND2|CC |2047|204 NF|CCNG 8|2324|37 2|CDK1|C 06|4052|4 DK6|EPH 214|4233| B1|EPHB2 4751|491 |FLT4|ITP 6|5156|55 KA|LTBP1| 63|5587|5 MAP3K1| 593|5600| MET|NEK 5891|650 2|NTRK3| GO 3|6790|70 PDGFRA| GO:00167 phosphotransferase activity, alcohol group 1 -7.34105 M1 1 0 Molecular 21 -7.34105 2.179361 6.180842 24156 711 873 56 6.414662 0.829247 75|7272|7 PRKAA2|P -4.88088 0 16 0 0 -8.49261 2.419993 73 as acceptor Functions 465|8317| RKD1|PRK 8767|906 G2|MAPK 1|9133|91 11|MOK|S 34|9833|1 LA|AURK 0733|231 A|TIE1|TT 78|29941| K|WEE1|C 53904|54 DC7|RIPK 757|5535 2|PAPSS1| 9|55728|5 CCNB2|C 6155|571 CNE2|ME 72|57538| LK|PLK4|P 79675|81 ASK|PKN3 788|8468 |MYO3A|F 7|84930|8 AM20A|S BMP7|CD 655|947|1 34|COL5A 289|1490| 1|CCN2|F 2200|224 BN1|FGF2 7|2335|30 |FN1|CFH| 75|3673|4 ITGA2|LT 053|4089| BP2|SMA 4316|516 D4|MMP7 7|5228|52 |ENPP1|P GO 70|6422|7 GF|SERPI GO:19016 1 -7.26464 M1 1 0 Molecular 21 sulfur compound binding -7.26464 3.146796 6.673352 24156 255 873 29 3.321879 0.606525 057|7058| NE2|SFRP -4.81334 0 22 0 0 -7.55129 3.438297 81 Functions 9388|950 1|THBS1| 8|10468|1 THBS2|LI 0631|513 PG|ADAM 63|79723| TS3|FST|P 84570|14 OSTN|CH 9998|151 ST15|SUV 887|1547 39H2|CO 43|34041 L25A1|LIP 9 I|CCDC80 |BMT2|RS GO 8772|834 FADD|PL GO:00026 1 -1.41425 M1 1 0 Biological 19 positive regulation of cellular extravasation -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 83|72923 VAP|CCR -0.29981 0 0 93 Processes 0 2 COL4A5| COL4A6| 1287|128 COL5A1| 8|1289|12 COL7A1| 94|1295|1 COL8A1| 299|2200| COL9A3|F R-HSA- Reactome 2335|367 1 -7.24934 M1 1 0 6 Integrin cell surface interactions -7.24934 5.20849 7.526271 24156 85 873 16 1.832761 0.453972 BN1|FN1|I -4.80268 0 23 0 0 -7.4807 8.301031 216083 Gene Sets 2|3673|36 TGA1|ITG 90|4060|5 A2|ITGB3| 175|7057| LUM|PEC 58494|13 AM1|THB 1873 S1|JAM2| COL6A6 BUB1|BU 699|701|9 B1B|CDK1 83|1062|1 |CENPE|E 894|6790| CT2|AUR Canonical 7465|104 1 -7.23866 M129 M1 1 0 11 PID PLK1 PATHWAY -7.23866 7.218288 8.174144 24156 46 873 12 1.37457 0.394068 KA|WEE1| -4.7964 0 25 1 1 -7.23866 13.83505 Pathways 03|22974| NDC80|T 54821|63 PX2|ERCC 967|7986 6L|CLSPN 6 |BORA 655|2199| BMP7|FBL 2200|220 N2|FBN1| 1|2335|36 FBN2|FN1 R-HSA- Reactome 1 -7.19731 M1 1 0 6 Molecules associated with elastic fibres -7.19731 8.009767 8.373671 24156 38 873 11 1.260023 0.37751 90|4052|4 |ITGB3|LT -4.75942 0 24 0 0 -7.35548 20.75258 2129379 Gene Sets 053|4237| BP1|LTBP 10516|84 2|MFAP2| 467 FBLN5|FB 238|699|7 ALK|BUB1 01|815|89 |BUB1B|C 4|899|901 AMK2A|C |983|1021 CND2|CC |1841|204 NF|CCNG 7|2048|23 2|CDK1|C 24|3706|4 DK6|DTY 052|4214| MK|EPHB 4233|475 1|EPHB2| 1|4916|51 FLT4|ITPK 56|5563|5 A|LTBP1| 587|5593| MAP3K1| 5600|563 MET|NEK GO 4|5891|65 2|NTRK3| GO:00163 1 -7.16657 M1 1 0 Molecular 21 kinase activity -7.16657 2.103784 6.051788 24156 776 873 59 6.758305 0.849605 03|6790|7 PDGFRA| -4.733 0 16 0 0 -8.49261 2.419993 01 Functions 075|7272| PRKAA2|P 7465|831 RKD1|PRK 7|8767|90 G2|MAPK 61|9133|9 11|PRPS2| 134|9833| MOK|SLA| 10733|23 AURKA|TI 178|2994 E1|TTK|W 1|50808|5 EE1|CDC7 3904|547 |RIPK2|PA 57|55359| PSS1|CCN 55728|56 B2|CCNE 155|5717 2|MELK|P 2|57538|7 LK4|PASK| 9675|817 PKN3|AK COL4A5| 1287|128 COL4A6| 8|1289|12 COL5A1| 94|2200|2 COL7A1|F 335|3672| BN1|FN1|I Canonical 1 -7.10343 M18 M1 1 0 11 PID INTEGRIN1 PATHWAY -7.10343 5.869416 7.670463 24156 66 873 14 1.603666 0.425147 3673|390 TGA1|ITG -4.67414 0 23 0 0 -7.4807 8.301031 Pathways 9|3914|70 A2|LAMA 57|7058|5 3|LAMB3| 8494|284 THBS1|TH 217 BS2|JAM2 |LAMA1 GO NFATC1|T GO:00031 4772|713 1 -1.41425 M1 1 0 Biological 19 pulmonary valve development -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 NFRSF1A| -0.29981 0 0 77 2|7133 Processes TNFRSF1 CDK1|NE 983|4751| K2|PCNT| 5116|679 AURKA|D 0|8655|91 YNLL1|CC 33|9662|9 NB2|CEP1 814|1073 R-HSA- Reactome Regulation of PLK1 Activity at G2/M 35|SFI1|PL 1 -7.0285 M1 1 0 6 -7.0285 5.030928 7.335294 24156 88 873 16 1.832761 0.453972 3|54820|5 -4.60764 0 12 0 0 -10.0997 6.06468 2565942 Gene Sets Transition K4|NDE1| 5125|558 CEP192|C 35|79441| ENPJ|HA 79866|80 US3|BOR 184|1214 A|CEP290 41 |NEDD1 GO AGTR2|T GO:00097 catechol-containing compound 186|7054| 1 -1.41425 M1 1 0 Biological 19 -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 H|MOXD -0.29981 0 0 13 biosynthetic process 26002 Processes 1 COL4A5| COL4A6| 1287|128 COL5A1| 8|1289|12 COL7A1| 94|1295|1 COL8A1| 299|1306| COL9A3| R-HSA- Reactome Collagen biosynthesis and modifying 1 -7.0162 M1 1 0 6 -7.0162 5.781813 7.589475 24156 67 873 14 1.603666 0.425147 7093|950 COL15A1| -4.60361 0 5 0 0 -15.2617 12.29782 1650814 Gene Sets enzymes 8|10491|5 TLL2|ADA 5214|845 MTS3|CR 70|13187 TAP|P3H2 3|136227 |COL25A1 |COL6A6| COL26A1 BIRC5|CD 332|983|1 K1|CENPE 062|1393| |CRHBP|KI 3832|475 F11|NEK2 1|5116|67 |PCNT|AU 90|7074|8 RKA|TIAM 655|9493| 1|DYNLL1 9585|992 |KIF23|KIF 8|11004|1 20B|KIF14 1104|229 |KIF2C|KA 74|24137| TNA1|TPX 26153|26 2|KIF4A|KI 586|5120 F26A|CKA GO 3|51512|5 P2|NUSA GO:00058 Cellular 1 -7.00015 M1 1 0 20 microtubule -7.00015 2.551144 6.23214 24156 423 873 39 4.467354 0.699188 4820|551 P1|GTSE1| -4.59164 0 8 0 0 -11.3911 5.158833 74 Compone 37|55835| NDE1|FIG nts 56890|57 N|CENPJ| 159|5761 MDM1|TR 9|79441|7 IM54|SHR 9861|810 OOM3|H 27|81930| AUS3|TU 85459|12 BAL3|TUB 6731|221 B1|KIF18A 150|2461 |CEP295| 76|25926 CCSAP|SK 6|344148| A3|GAS2L 347240|4 2|ASPM|N 40738 CKAP5|KI F24|MAP GO EDN2|ED GO:00148 1907|190 1 -1.41425 M1 1 0 Biological 19 phasic smooth muscle contraction -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 N3|HTR2 -0.29981 0 0 21 8|3357 Processes B GO GAS2|INH GO:00307 2620|362 1 -1.41425 M1 1 0 Biological 19 ovulation -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 BA|TNFAI -0.29981 0 0 28 4|7130 Processes P6 BIRC5|BU 332|699|7 B1|BUB1B 01|983|10 |CDK1|CE 62|1063|2 NPE|CEN 491|4001| PF|CENPI| 8655|913 LMNB1|D 3|9232|10 YNLL1|CC 403|1100 NB2|PTT 4|23421|5 G1|NDC8 R-HSA- Reactome 4820|548 0|KIF2C|IT 1 -6.89953 M1 1 0 6 Mitotic Anaphase -6.89953 3.179118 6.500043 24156 235 873 27 3.092784 0.58593 -4.50303 0 2 0 0 -22.074 10.54099 68882 Gene Sets 21|55706| GB3BP|N 55839|57 DE1|ERCC 082|5740 6L|NDC1| 5|79003|7 CENPN|K 9861|810 NL1|SPC2 27|81930| 5|MIS12|T 83540|91 UBAL3|TU 687|4015 BB1|KIF18 41 A|NUF2|C ENPL|CE BIRC5|BU 332|699|7 B1|BUB1B 01|983|10 |CDK1|CE 62|1063|2 NPE|CEN 491|4001| PF|CENPI| 8655|913 LMNB1|D 3|9232|10 YNLL1|CC 403|1100 NB2|PTT 4|23421|5 G1|NDC8 R-HSA- Reactome 4820|548 0|KIF2C|IT 1 -6.86165 M1 1 0 6 Mitotic Metaphase and Anaphase -6.86165 3.165647 6.473726 24156 236 873 27 3.092784 0.58593 -4.46908 0 2 0 0 -22.074 10.54099 2555396 Gene Sets 21|55706| GB3BP|N 55839|57 DE1|ERCC 082|5740 6L|NDC1| 5|79003|7 CENPN|K 9861|810 NL1|SPC2 27|81930| 5|MIS12|T 83540|91 UBAL3|TU 687|4015 BB1|KIF18 41 A|NUF2|C ENPL|CE ACTN1|C 87|1287|1 OL4A5|C 288|1289| OL4A6|C 2247|233 OL5A1|FG R-HSA- Reactome 5|3673|36 F2|FN1|IT 1 -6.84624 M1 1 0 6 Non-integrin membrane-ECM interactions -6.84624 6.096802 7.589855 24156 59 873 13 1.489118 0.40992 -4.45757 0 23 0 0 -7.4807 8.301031 3000171 Gene Sets 90|3691|3 GA2|ITGB 909|3914| 3|ITGB4|L 7057|284 AMA3|LA 217 MB3|THB S1|LAMA GO ADORA2 GO:00358 135|186|1 1 -1.41425 M1 1 0 Biological 19 regulation of renal sodium excretion -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 A|AGTR2| -0.29981 0 0 13 312 Processes COMT GO BHMT|D GO:00424 635|2995 1 -1.41425 M1 1 0 Biological 19 cellular biogenic amine catabolic process -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 MGDH|C -0.29981 0 0 02 8|55349 Processes HDH CDK1|CE 983|1063| NPF|HM 3161|475 MR|NEK2| 1|5116|67 PCNT|AU 90|7465|8 RKA|WEE 655|9133| 1|DYNLL1 9662|981 |CCNB2|C 4|10733|2 EP135|SFI R-HSA- Reactome 2974|515 1 -6.71862 M1 1 0 6 G2/M Transition -6.71862 3.388176 6.50043 24156 196 873 24 2.749141 0.553399 1|PLK4|TP -4.34143 0 12 0 0 -10.0997 6.06468 69275 Gene Sets 12|54820| X2|GTSE1 55125|55 |NDE1|CE 835|7944 P192|CEN 1|79861|7 PJ|HAUS3 9866|801 |TUBAL3| 84|81027| BORA|CE 121441|2 P290|TUB 86826 B1|NEDD CCNF|PC 899|5116| NT|STIL|A 6491|679 URKA|TO 0|7153|96 P2A|CEP1 62|9814|1 35|SFI1|PL 0733|258 K4|POC1 GO 86|51098| A|IFT52|C GO:00058 Cellular 55125|55 1 -6.63981 M1 1 0 20 centriole -6.63981 3.869944 6.665143 24156 143 873 20 2.290951 0.50637 EP192|CE -4.26638 0 12 0 0 -10.0997 6.06468 14 Compone 165|5583 P55|CENP nts 5|56890|8 J|MDM1| 0184|854 CEP290|L 44|85459| RRCC1|CE 121441|1 P295|NED 26731|34 D1|CCSA 7240 P|KIF24 CDK1|CE 983|1063| NPF|HM 3161|475 MR|NEK2| 1|5116|67 PCNT|AU 90|7465|8 RKA|WEE 655|9133| 1|DYNLL1 9662|981 |CCNB2|C 4|10733|2 EP135|SFI R-HSA- Reactome 2974|515 1 -6.63576 M1 1 0 6 Mitotic G2-G2/M phases -6.63576 3.353952 6.440151 24156 198 873 24 2.749141 0.553399 1|PLK4|TP -4.26605 0 12 0 0 -10.0997 6.06468 453274 Gene Sets 12|54820| X2|GTSE1 55125|55 |NDE1|CE 835|7944 P192|CEN 1|79861|7 PJ|HAUS3 9866|801 |TUBAL3| 84|81027| BORA|CE 121441|2 P290|TUB 86826 B1|NEDD BIRC5|BU 332|699|7 B1|BUB1B 01|1062|1 |CENPE|C 063|1894| ENPF|ECT 2491|301 2|CENPI| 5|5600|70 H2AZ1|M 74|7456|8 APK11|TI 357|8655| AM1|WIP 9824|992 F1|H3C10 8|9938|10 |DYNLL1| 276|1040 ARHGAP1 3|10788|1 1A|KIF14| 1004|234 ARHGAP2 21|23433| 5|NET1|N R-HSA- Reactome 1 -6.61418 M1 1 0 6 Signaling by Rho GTPases -6.61418 2.432537 5.973368 24156 455 873 40 4.581901 0.707671 26084|29 DC80|IQG -4.24817 0 2 0 0 -22.074 10.54099 194315 Gene Sets 941|5065 AP2|KIF2 0|54820|5 C|ITGB3B 4821|557 P|RHOQ| 89|55839| ARHGEF2 57082|57 6|PKN3|A 381|5740 RHGEF3| 5|79003|7 NDE1|ER 9861|810 CC6L|DEP 27|81930| DC1B|CE 83540|91 NPN|KNL 687|4015 1|RHOJ|S 41|65360 PC25|MIS 4 12|TUBAL 3|TUBB1| ACTN1|XI AP|CCND 87|331|89 2|COL4A5 4|1287|12 |COL4A6| 88|1299|2 COL9A3| 277|2324| VEGFD|FL 2335|367 T4|FN1|IT 2|3673|36 GA1|ITGA KEGG 90|3691|3 2|ITGB3|I 1 -6.59478 hsa04510 M1 1 0 24 Focal adhesion -6.59478 3.337098 6.410301 24156 199 873 24 2.749141 0.553399 -4.23244 0 23 0 0 -7.4807 8.301031 Pathway 909|3914| TGB4|LA 4233|515 MA3|LAM 6|5228|70 B3|MET|P 57|7058|2 DGFRA|P 9780|560 GF|THBS1 34|13187 |THBS2|P 3|284217 ARVB|PD GFC|COL 6A6|LAM GO AGTR2|T GO:00424 186|7054| 1 -1.41425 M1 1 0 Biological 19 catecholamine biosynthetic process -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 H|MOXD -0.29981 0 0 23 26002 Processes 1 XIAP|CDK 331|1021| 6|CDKN2 1030|116 B|CKS2|C 4|1287|12 OL4A5|C 88|1870|2 OL4A6|E2 KEGG 1 -6.5219 hsa05222 M1 1 0 24 Small cell lung cancer -6.5219 4.94109 7.006338 24156 84 873 15 1.718213 0.439813 335|3673| F2|FN1|IT -4.16679 0 27 1 1 -6.5219 4.94109 Pathway 3909|391 GA2|LAM 4|6258|91 A3|LAMB 34|79444| 3|RXRG|C 284217 CNE2|BIR C7|LAMA GO GO:00461 2618|547 GART|PP 1 -1.41425 M1 1 0 Biological 19 nucleobase biosynthetic process -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 -0.29981 0 0 12 1|10606 AT|PAICS Processes GO BARD1|M GO:00468 negative regulation of nucleocytoplasmic 580|2996 1 -1.41425 M1 1 0 Biological 19 -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 DFIC|RAB -0.29981 0 0 23 transport 9|51715 Processes 23 GO MECOM| GO:00708 2122|307 1 -1.41425 M1 1 0 Biological 19 heterochromatin organization -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 HELLS|LO -0.29981 0 0 28 0|4017 Processes XL2 GO 4916|228 NTRK3|N GO:00986 1 -1.41425 M1 1 0 Biological 19 postsynaptic specialization assembly -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 71|34773 LGN1|LRR -0.29981 0 0 98 Processes 0 TM1 GO ADORA2 GO:19002 positive regulation of long-term synaptic 135|1385| 1 -1.41425 M1 1 0 Biological 19 -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 A|CREB1| -0.29981 0 0 73 potentiation 2048 Processes EPHB2 ACTN2|A GTR2|AH R|BRCA1| 88|186|19 CAMK2A| 6|672|815 CHRM3|C |1131|138 REB1|CRH 5|1393|13 BP|CRHR 95|1583|1 2|CYP11A 816|2200| 1|DRD5|F 2902|326 BN1|GRIN 9|4208|51 1|HRH1| 56|5167|5 GO MEF2C|P GO:19016 179|5471| 1 -1.41394 M1 1 0 Biological 19 cellular response to nitrogen compound -1.41394 1.383505 1.93436 24156 660 873 33 3.780069 0.645469 DGFRA|E -0.29972 0 0 99 6422|693 Processes NPP1|PE 5|7054|87 NK|PPAT| 67|10891| SFRP1|ZE 23433|54 B1|TH|RIP 464|5502 K2|PPAR 3|56034|8 GC1A|RH 4687|853 OQ|XRN1 97|13306 |PHIP|PD 0|143686| GFC|PPP1 652968 R9B|RGS8 |OTOP1|S ESN3|CAS BRCA1|C 672|899|5 CNF|PCN 116|5420| T|PODXL| 6491|679 STIL|AUR 0|7153|96 KA|TOP2 62|9787|9 A|CEP135 814|1046 |DLGAP5| 0|10733|2 SFI1|TAC 5886|510 GO C3|PLK4|P 98|55112| GO:00444 Cellular OC1A|IFT 1 -6.38983 M1 1 0 20 microtubule organizing center part -6.38983 3.000373 6.14383 24156 249 873 27 3.092784 0.58593 55125|55 -4.05915 0 12 0 0 -10.0997 6.06468 50 Compone 52|WDR6 165|5519 nts 0|CEP192| 6|55835|5 CEP55|RE 6890|801 SF1|CENP 84|85444| J|MDM1| 85459|11 CEP290|L 7178|121 RRCC1|CE 441|1267 P295|SSX 31|34724 2IP|NEDD 0 1|CCSAP| BIRC5|BU 332|699|7 B1|BUB1B 01|1062|1 |CENPE|C 063|2491| ENPF|CE 8655|923 NPI|DYNL 2|10403|1 L1|PTTG1| 1004|234 NDC80|KI 21|54820| F2C|ITGB R-HSA- Reactome 1 -6.37605 M1 1 0 6 Separation of Sister Chromatids -6.37605 3.349539 6.295827 24156 190 873 23 2.634593 0.542066 54821|55 3BP|NDE -4.04874 0 2 0 0 -22.074 10.54099 2467813 Gene Sets 839|5708 1|ERCC6L| 2|57405|7 CENPN|K 9003|798 NL1|SPC2 61|81027| 5|MIS12|T 81930|83 UBAL3|TU 540|9168 BB1|KIF18 7|401541 A|NUF2|C ENPL|CE 4089|420 SMAD4| GO GO:00031 8|4772|54 MEF2C|N 1 -1.4072 M1 1 0 Biological 19 heart valve morphogenesis -1.4072 2.660587 2.321186 24156 52 873 5 0.572738 0.255402 -0.29764 0 0 79 567|6426 FATC1|DL Processes 58 L4|SCX 1385|290 CREB1|GR GO GO:00076 2|3269|11 IN1|HRH1 1 -1.4072 M1 1 0 Biological 19 visual behavior -1.4072 2.660587 2.321186 24156 52 873 5 0.572738 0.255402 -0.29764 0 0 32 346|1643 |SYNPO|L Processes 12 RRN4 CAMK2A| GO 815|2048| GO:00481 EPHB2|G 1 -1.4072 M1 1 0 Biological 19 regulation of neuronal synaptic plasticity -1.4072 2.660587 2.321186 24156 52 873 5 0.572738 0.255402 2902|113 -0.29764 0 0 68 RIN1|SYN Processes 46|23237 PO|ARC 1490|642 CCN2|SFR GO GO:00514 2|22843|2 P1|PPM1 1 -1.4072 M1 1 0 Biological 19 positive regulation of stress fiber assembly -1.4072 2.660587 2.321186 24156 52 873 5 0.572738 0.255402 -0.29764 0 0 96 2998|289 E|LIMCH1 Processes 84 |RGCC ACTN1|A CTN2|CD 87|88|100 H5|CDH7| 3|1005|10 CDH9|CD 07|1008|1 H10|CDH 009|1266| 11|CNN3| 1289|149 COL5A1| 0|2200|22 CCN2|FB 47|2335|3 N1|FGF2| 673|3690| FN1|ITGA 3691|390 2|ITGB3|I 9|3914|43 TGB4|LA 61|5795|6 MA3|LAM 387|6642| GO B3|MRE1 GO:00508 7057|722 1 -6.28754 M1 1 0 Molecular 21 cell adhesion molecule binding -6.28754 2.305842 5.736713 24156 504 873 42 4.810997 0.724275 1|PTPRJ|C -3.98145 0 32 1 1 -6.28754 6.917526 39 3|8357|87 Functions XCL12|SN 27|9133|1 X1|THBS1 0516|106 |TRPC4|H 06|10631| 3C10|CTN 11082|22 NAL1|CC 871|2597 NB2|FBLN 5|26156|2 5|PAICS|P 9091|297 OSTN|ES 66|54443| M1|NLGN 57650|58 1|EGFL6|R 494|6407 SL1D1|ST 2|83872|2 XBP6|TM 22256 OD3|ANL N|CIP2A|J ADORA2 GO 135|1816| GO:00973 A|DRD5|G 1 -1.4072 M1 1 0 Biological 19 response to bronchodilator -1.4072 2.660587 2.321186 24156 52 873 5 0.572738 0.255402 2902|705 -0.29764 0 0 66 RIN1|TH| Processes 4|84687 PPP1R9B THBS1|TH BS2|ADA 7057|705 MTS3|AD 8|9508|97 AMTSL2| 19|11174| ADAMTS R-HSA- Reactome Defective B3GALTL causes Peters-plus 1 -6.2858 M1 1 0 6 -6.2858 7.478406 7.636258 24156 37 873 10 1.145475 0.360151 54437|55 6|SEMA5 -3.98145 0 33 1 1 -6.2858 7.478406 5083635 Gene Sets syndrome (PpS) 901|5718 B|THSD1| 8|80731|1 ADAMTS 70692 L3|THSD7 B|ADAMT S18 ADORA2 A|CYP1B1 135|1545| |DAB1|LG 1600|395 ALS3|MB 8|4155|52 P|SERPIN 70|5420|6 E2|PODXL GO 387|7057| GO:00071 |CXCL12| 1 -1.40493 M1 1 0 Biological 19 negative regulation of cell adhesion -1.40493 1.599972 2.004206 24156 294 873 17 1.947308 0.467671 9723|106 -0.29764 0 0 62 THBS1|SE Processes 31|28984| MA3E|PO 55824|58 STN|RGC 494|7967 C|PAG1|J 9|170692| AM2|VTC 441478 N1|ADA MTS18|N CRHBP|E 1393|189 CT2|MEF2 4|4208|51 C|PENK|P GO 79|5563|7 GO:00515 RKAA2|T 1 -1.40359 M1 1 0 Biological 19 response to calcium ion -1.40359 1.895213 2.100863 24156 146 873 10 1.145475 0.360151 057|7139| -0.29764 0 0 92 HBS1|TN Processes 10369|22 NT2|CAC 871|1518 NG2|NLG 35 N1|CPNE ESRRB|HR 2103|326 H1|ENPP 9|5167|53 1|PMAIP1 66|5563|6 |PRKAA2| GO 095|9104| GO:00061 regulation of carbohydrate metabolic RORA|RG 1 -1.40237 M1 1 0 Biological 19 -1.40237 1.729381 2.045705 24156 208 873 13 1.489118 0.40992 10891|23 -0.29764 0 0 09 process N|PPARG Processes 178|5570 C1A|PASK 6|57486|8 |NDC1|NL 5414|114 N|SLC45A 899 3|C1QTN GO GO:00000 9493|241 KIF23|KIF 1 -1.40148 M1 1 0 Biological 19 mitotic spindle elongation -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 22 37 4A Processes THBS1|TH BS2|ADA 7057|705 MTS3|AD 8|9508|97 AMTSL2| 19|11174| ADAMTS R-HSA- Reactome O-glycosylation of TSR domain-containing 1 -6.16742 M1 1 0 6 -6.16742 7.281606 7.503831 24156 38 873 10 1.145475 0.360151 54437|55 6|SEMA5 -3.87874 0 33 0 0 -6.2858 7.478406 5173214 Gene Sets proteins 901|5718 B|THSD1| 8|80731|1 ADAMTS 70692 L3|THSD7 B|ADAMT S18 GO GO:00033 655|5456 BMP7|DL 1 -1.40148 M1 1 0 Biological 19 pericardium morphogenesis -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 44 7 L4 Processes COL4A5| 1287|128 COL4A6| 8|1294|36 COL7A1|I R-HSA- Reactome 72|3673|3 TGA1|ITG 1 -6.13745 M1 1 0 6 Laminin interactions -6.13745 8.301031 7.748066 24156 30 873 9 1.030928 0.341867 -3.85489 0 23 0 0 -7.4807 8.301031 3000157 Gene Sets 691|3909| A2|ITGB4| 3914|284 LAMA3|L 217 AMB3|LA MA1 GO GO:00091 nucleoside diphosphate biosynthetic 1841|508 DTYMK|A 1 -1.40148 M1 1 0 Biological 19 -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 33 process 08 K3 Processes BMP7|CO 655|1289| L5A1|CC 1490|220 N2|FBN1| 0|2247|23 FGF2|FN1 35|3075|4 |CFH|LTB 053|4316| P2|MMP7 GO 5228|527 |PGF|SER GO:00082 1 -6.06522 M1 1 0 Molecular 21 heparin binding -6.06522 3.438297 6.159325 24156 169 873 21 2.405498 0.518571 0|6422|70 PINE2|SF -3.78887 0 22 0 0 -7.55129 3.438297 01 Functions 57|7058|9 RP1|THBS 388|9508| 1|THBS2|L 10631|84 IPG|ADA 570|1499 MTS3|PO 98|15188 STN|COL 7|340419 25A1|LIPI| CCDC80| CDK1|CC 983|9133| NB2|SMC R-HSA- Reactome Condensation of Prometaphase 10051|10 1 -6.06241 M1 1 0 6 -6.06241 15.09278 9.052545 24156 11 873 6 0.687285 0.279617 4|SMC2|N -3.78887 0 36 1 1 -6.06241 22.13608 2514853 Gene Sets Chromosomes 592|2339 CAPH|NC 7|64151 APG 332|699|6 BIRC5|BU 790|9493| B1|AURK 10051|10 A|KIF23|S Canonical 1 -6.05299 M14 M1 1 0 11 PID AURORA B PATHWAY -6.05299 7.094898 7.376125 24156 39 873 10 1.145475 0.360151 403|1059 MC4|NDC -3.78399 0 36 0 0 -6.06241 22.13608 Pathways 2|11004|2 80|SMC2| 3397|641 KIF2C|NC 51 APH|NCA GO GO:00092 pyrimidine deoxyribonucleotide 1841|185 DTYMK|D 1 -1.40148 M1 1 0 Biological 19 -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 21 biosynthetic process 4 UT Processes FAS|CCN 355|894|9 D2|CCNG 01|983|10 2|CDK1|C 21|5366|6 DK6|PMA KEGG 241|7057| IP1|RRM2 1 -6.01116 hsa04115 M1 1 0 24 p53 signaling pathway -6.01116 5.213208 6.786365 24156 69 873 13 1.489118 0.40992 -3.74646 0 37 1 1 -6.01116 5.929308 Pathway 9133|913 |THBS1|C 4|51512|8 CNB2|CC 5417|143 NE2|GTSE 686 1|CCNB3| SESN3 GO GO:00106 3673|420 ITGA2|ME 1 -1.40148 M1 1 0 Biological 19 regulation of alkaline phosphatase activity -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 92 8 F2C Processes GO GO:00109 23397|29 NCAPH|U 1 -1.40148 M1 1 0 Biological 19 regulation of isomerase activity -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 11 128 HRF1 Processes BIRC5|BU 332|699|7 B1|BUB1B 01|1062|1 |CENPE|C 063|2491| ENPF|CE 3015|560 NPI|H2AZ 0|7456|83 1|MAPK1 57|8655|9 1|WIPF1| 928|1040 H3C10|D 3|10788|1 YNLL1|KIF 1004|234 14|NDC8 21|23433| 0|IQGAP2 R-HSA- Reactome 1 -5.94926 M1 1 0 6 RHO GTPase Effectors -5.94926 2.62316 5.722336 24156 327 873 31 3.550974 0.626348 29941|54 |KIF2C|IT -3.69491 0 2 0 0 -22.074 10.54099 195258 Gene Sets 820|5482 GB3BP|R 1|55839|5 HOQ|PKN 7082|574 3|NDE1|E 05|79003| RCC6L|CE 79861|81 NPN|KNL 027|8193 1|SPC25| 0|83540|9 MIS12|TU 1687|401 BAL3|TUB 541|6536 B1|KIF18A 04 |NUF2|CE NPL|CEN XIAP|BIRC 5|FAS|BR CA2|CDK 331|332|3 6|CDKN2 55|675|10 B|CKS2|C 21|1030|1 OL4A5|C 164|1287| OL4A6|E2 1288|187 F2|MECO 0|2122|22 M|FGF2|V 47|2277|2 EGFD|FN 335|2535| 1|FZD2|LP 2846|367 AR4|ITGA 3|3909|39 KEGG 2|LAMA3| 1 -5.9442 hsa05200 M1 1 0 24 Pathways in cancer -5.9442 2.451781 5.633244 24156 395 873 35 4.009164 0.663949 14|4089|4 -3.69491 0 27 0 0 -6.5219 4.94109 Pathway LAMB3|S 233|4312| MAD4|M 5156|522 ET|MMP1 8|6258|63 |PDGFRA| 87|7852|8 PGF|RXR 325|8772| G|CXCL12 9134|101 |CXCR4|F 25|25780| ZD8|FAD 79444|80 D|CCNE2| 326|2842 RASGRP1| 17 RASGRP3| BIRC7|W NT10A|LA GO GO:00109 23397|29 NCAPH|U 1 -1.40148 M1 1 0 Biological 19 positive regulation of isomerase activity -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 12 128 HRF1 Processes GO GO:00148 2047|508 EPHB1|PA 1 -1.40148 M1 1 0 Biological 19 skeletal muscle satellite cell differentiation -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 16 1 X7 Processes 983|4751| CDK1|NE 5116|865 K2|PCNT| 5|9662|98 DYNLL1|C 14|10733| EP135|SFI R-HSA- Reactome 1 -5.93642 M1 1 0 6 Loss of Nlp from mitotic centrosomes -5.93642 5.138733 6.71468 24156 70 873 13 1.489118 0.40992 54820|55 1|PLK4|N -3.69442 0 12 0 0 -10.0997 6.06468 380259 Gene Sets 125|5583 DE1|CEP1 5|79441|8 92|CENPJ| 0184|121 HAUS3|C 441 EP290|NE 983|4751| CDK1|NE 5116|865 K2|PCNT| 5|9662|98 DYNLL1|C Loss of proteins required for interphase 14|10733| EP135|SFI R-HSA- Reactome 1 -5.93642 M1 1 0 6 microtubule organization from the -5.93642 5.138733 6.71468 24156 70 873 13 1.489118 0.40992 54820|55 1|PLK4|N -3.69442 0 12 0 0 -10.0997 6.06468 380284 Gene Sets centrosome 125|5583 DE1|CEP1 5|79441|8 92|CENPJ| 0184|121 HAUS3|C 441 EP290|NE GO GO:00302 ACTC1|PR 1 -1.40148 M1 1 0 Biological 19 skeletal muscle thin filament assembly -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 70|5629 -0.29764 0 0 40 OX1 Processes GO GO:00423 1381|159 CRABP1| 1 -1.40148 M1 1 0 Biological 19 fat-soluble vitamin catabolic process -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 63 1 CYP24A1 Processes GO GO:00424 1312|260 COMT|M 1 -1.40148 M1 1 0 Biological 19 dopamine catabolic process -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 20 02 OXD1 Processes GO GO:00456 negative regulation of monocyte 1021|811 CDK6|GP 1 -1.40148 M1 1 0 Biological 19 -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 56 differentiation 1 R68 Processes CDK1|NE 983|4751| K2|PCNT| 5116|865 DYNLL1|C 5|9662|98 EP135|SFI 14|10733| 1|PLK4|N R-HSA- Reactome Recruitment of NuMA to mitotic 54820|55 1 -5.87012 M1 1 0 6 -5.87012 4.415442 6.424453 24156 94 873 15 1.718213 0.439813 DE1|CEP1 -3.64174 0 12 0 0 -10.0997 6.06468 380320 Gene Sets centrosomes 125|5583 92|CENPJ| 5|79441|7 HAUS3|T 9861|801 UBAL3|CE 84|81027| P290|TUB 121441 B1|NEDD 70|87|88| ACTC1|A 135|332|9 CTN1|AC 83|1062|1 TN2|ADO 393|2620| RA2A|BIR 3832|386 C5|CDK1| 1|4001|47 CENPE|C 51|5010|5 RHBP|GA 116|6790| S2|KIF11| 7074|745 KRT14|LM 6|8655|94 NB1|NEK 93|9585|9 2|CLDN11 645|9928| |PCNT|AU 11004|11 RKA|TIAM GO 104|2297 1|WIPF1| GO:00995 Cellular 1 -5.83934 M1 1 0 20 polymeric cytoskeletal fiber -5.83934 1.986949 5.324143 24156 752 873 54 6.185567 0.8153 4|23433|2 DYNLL1|K -3.61363 0 8 0 0 -11.3911 5.158833 13 Compone 4137|261 IF23|KIF2 nts 53|26586| 0B|MICAL 27295|51 2|KIF14|KI 203|5151 F2C|KATN 2|53904|5 A1|TPX2| 4820|551 RHOQ|KI 37|55835| F4A|KIF26 56890|57 A|CKAP2| 159|5761 PDLIM3| 9|79441|7 NUSAP1| 9861|810 GTSE1|M 27|81930| YO3A|ND 84823|85 E1|FIGN|C 459|9252 ENPJ|MD GO GO:00466 regulation of mitotic centrosome 3832|475 KIF11|NE 1 -1.40148 M1 1 0 Biological 19 -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 02 separation 1 K2 Processes GO GO:00488 5629|147 PROX1|C 1 -1.40148 M1 1 0 Biological 19 venous blood vessel morphogenesis -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 45 372 CBE1 Processes 88|135|72 ACTN2|A 0|794|815 DORA2A| |1131|126 C4A|CALB 6|1312|13 2|CAMK2 93|1395|2 A|CHRM3 047|2048| |CNN3|C 2555|255 OMT|CRH 6|2557|25 BP|CRHR 65|2890|2 2|EPHB1| 902|2913| EPHB2|G 3269|335 ABRA2|G 7|3706|37 ABRA3|G 39|3759|5 ABRA4|G GO 179|5563| ABRG1|G GO:00304 Cellular 1 -5.7705 M1 1 0 20 dendrite -5.7705 2.075258 5.338411 24156 640 873 48 5.498282 0.771483 6456|705 RIA1|GRI -3.55271 0 41 1 1 -5.7705 2.075258 25 Compone 4|7074|84 N1|GRM3 nts 92|9312|1 |HRH1|HT 0590|108 R2B|ITPK 91|11141| A|KCNA4| 11346|22 KCNJ2|PE 871|2323 NK|PRKA 7|26037|3 A2|SH3GL 0001|510 2|TH|TIA 98|54464| M1|PRSS1 57537|84 2|KCNB2| 687|8539 SCGN|PP 7|85442|3 ARGC1A|I 39479|39 L1RAPL1| 2617|729 SYNPO|N GO GO:00601 2902|846 GRIN1|PP 1 -1.40148 M1 1 0 Biological 19 male mating behavior -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 79 87 P1R9B Processes GO GO:00602 5795|104 PTPRJ|YA 1 -1.40148 M1 1 0 Biological 19 contact inhibition -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 42 13 P1 Processes 88|135|72 ACTN2|A 0|794|815 DORA2A| |1131|126 C4A|CALB 6|1312|13 2|CAMK2 93|1395|2 A|CHRM3 047|2048| |CNN3|C 2555|255 OMT|CRH 6|2557|25 BP|CRHR 65|2890|2 2|EPHB1| 902|2913| EPHB2|G 3269|335 ABRA2|G 7|3706|37 ABRA3|G 39|3759|5 ABRA4|G GO 179|5563| ABRG1|G GO:00974 Cellular 1 -5.73285 M1 1 0 20 dendritic tree -5.73285 2.068793 5.314825 24156 642 873 48 5.498282 0.771483 6456|705 RIA1|GRI -3.52284 0 41 0 0 -5.7705 2.075258 47 Compone 4|7074|84 N1|GRM3 nts 92|9312|1 |HRH1|HT 0590|108 R2B|ITPK 91|11141| A|KCNA4| 11346|22 KCNJ2|PE 871|2323 NK|PRKA 7|26037|3 A2|SH3GL 0001|510 2|TH|TIA 98|54464| M1|PRSS1 57537|84 2|KCNB2| 687|8539 SCGN|PP 7|85442|3 ARGC1A|I 39479|39 L1RAPL1| 2617|729 SYNPO|N GO GO:00602 4208|562 MEF2C|P 1 -1.40148 M1 1 0 Biological 19 regulation of sarcomere organization -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 97 9 ROX1 Processes GO GO:00715 death-inducing signaling complex 7132|877 TNFRSF1 1 -1.40148 M1 1 0 Biological 19 -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 50 assembly 2 A|FADD Processes ACTN1|A 87|88|128 CTN2|CO 9|1490|22 L5A1|CC 00|2247|2 N2|FBN1| 335|3673| FGF2|FN1 GO 3690|369 |ITGA2|IT GO:00051 1 -5.63901 M1 1 0 Molecular 21 integrin binding -5.63901 3.635488 5.990113 24156 137 873 18 2.061856 0.480948 1|3909|39 GB3|ITGB -3.43664 0 23 0 0 -7.4807 8.301031 78 Functions 14|6387|7 4|LAMA3| 057|1051 LAMB3|C 6|11082|2 XCL12|TH 5975|584 BS1|FBLN 94 5|ESM1|E GFL6|JAM GO GO:00721 4208|515 MEF2C|P 1 -1.40148 M1 1 0 Biological 19 glomerulus morphogenesis -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 02 6 DGFRA Processes GO GO:00970 3280|102 HES1|RA 1 -1.40148 M1 1 0 Biological 19 vascular smooth muscle cell development -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 84 66 MP2 Processes GO GO:00989 2902|139 GRIN1|PT 1 -1.40148 M1 1 0 Biological 19 excitatory chemical synaptic transmission -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 76 411 CHD1 Processes GO GO:19018 983|1089 CDK1|PP 1 -1.40148 M1 1 0 Biological 19 positive regulation of cellular respiration -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 57 1 ARGC1A Processes GO GO:19019 5629|104 PROX1|N 1 -1.40148 M1 1 0 Biological 19 positive regulation of cell cycle checkpoint -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 78 03 DC80 Processes COL4A5| COL4A6| 1287|128 COL5A1| 8|1289|12 COL7A1| 94|1295|1 COL8A1| R-HSA- Reactome 299|1306| COL9A3| 1 -5.57187 M1 1 0 6 Collagen degradation -5.57187 5.188144 6.496304 24156 64 873 12 1.37457 0.394068 -3.38439 0 5 0 0 -15.2617 12.29782 1442490 Gene Sets 4312|431 COL15A1| 6|84570|1 MMP1|M 31873|13 MP7|COL 6227 25A1|COL 6A6|COL2 6A1 COL4A5| COL4A6| 1287|128 COL5A1| 8|1289|12 COL7A1| 94|1295|1 COL8A1| GO 299|1306| COL9A3| GO:00055 Cellular 4060|845 1 -5.56454 M1 1 0 20 collagen trimer -5.56454 4.45266 6.247059 24156 87 873 14 1.603666 0.425147 COL15A1| -3.3795 0 5 0 0 -15.2617 12.29782 81 Compone 70|11489 LUM|COL nts 9|131873| 25A1|C1 136227|1 QTNF3|C 47372|34 OL6A6|C 2035 OL26A1|C CBE1|GLD GO GO:19024 positive regulation of stem cell population 2103|104 ESRRB|YA 1 -1.40148 M1 1 0 Biological 19 -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 59 maintenance 13 P1 Processes C4A|CHG B|COL4A 720|1114| 5|COL4A6 1287|128 |COL5A1| 8|1289|12 COL7A1| 94|1295|1 COL8A1| 299|1306| COL9A3| 1356|146 COL15A1| 2|2157|22 CP|VCAN| GO 00|2335|2 F8|FBN1|F GO:00057 Cellular 882|4052| N1|GPX7| 1 -5.54756 M1 1 0 20 endoplasmic reticulum lumen -5.54756 2.605302 5.490315 24156 308 873 29 3.321879 0.606525 -3.36735 0 43 1 1 -5.54756 2.605302 88 Compone 5179|705 LTBP1|PE nts 7|9403|95 NK|THBS 63|10491| 1|SELENO 30001|55 F|H6PD|C 214|5603 RTAP|ER 4|81619|8 O1A|P3H 4570|918 2|PDGFC| 51|13622 TSPAN14| 7|143888 COL25A1| CHRDL1| COL26A1| COL4A5| COL4A6| 1287|128 COL5A1| 8|1289|12 COL7A1| 94|1295|1 Canonical COL8A1| 1 -5.53273 M3005 M1 1 0 11 NABA COLLAGENS -5.53273 6.28866 6.799023 24156 44 873 10 1.145475 0.360151 299|1306| -3.35729 0 5 0 0 -15.2617 12.29782 Pathways COL9A3| 84570|13 COL15A1| 1873|136 COL25A1| 227 COL6A6| COL26A1 COL4A5| COL4A6| 1287|128 COL5A1| 8|1289|12 COL7A1| 94|1295|1 R-HSA- Reactome COL8A1| 1 -5.53273 M1 1 0 6 Collagen chain trimerization -5.53273 6.28866 6.799023 24156 44 873 10 1.145475 0.360151 299|1306| -3.35729 0 5 0 0 -15.2617 12.29782 8948216 Gene Sets COL9A3| 84570|13 COL15A1| 1873|136 COL25A1| 227 COL6A6| COL26A1 BRCA1|BR 672|675|2 CA2|FAN 187|2188| CB|FANC 3280|539 KEGG F|HES1|P 1 -5.52611 hsa03460 M1 1 0 24 Fanconi anemia pathway -5.52611 5.636502 6.604683 24156 54 873 11 1.260023 0.37751 5|55215|8 -3.35396 0 44 1 1 -5.52611 9.223368 Pathway MS2|FAN 0010|914 CI|RMI1|F 42|14695 AAP24|E 6|353497 ME1|POL GO GO:19033 4208|517 MEF2C|PE 1 -1.40148 M1 1 0 Biological 19 regulation of fear response -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 65 9 NK Processes GO GO:19038 655|1444 BMP7|E2F 1 -1.40148 M1 1 0 Biological 19 extraembryonic membrane development -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 67 55 7 Processes GO 10051|10 SMC4|SM GO:00007 Cellular 592|2339 C2|NCAP 1 -5.50625 M1 1 0 20 condensin complex -5.50625 17.29381 8.925208 24156 8 873 5 0.572738 0.255402 -3.3402 0 36 0 0 -6.06241 22.13608 96 Compone 7|54892|6 H|NCAPG nts 4151 2|NCAPG GO GO:20008 4208|517 MEF2C|PE 1 -1.40148 M1 1 0 Biological 19 regulation of behavioral fear response -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 22 9 NK Processes GO 7520|544 XRCC5|XR GO:00322 negative regulation of telomere 1 -1.39849 M1 1 0 Biological 19 -1.39849 3.074456 2.411893 24156 36 873 4 0.45819 0.22857 64|80119| N1|PIF1|C -0.29545 0 0 05 maintenance Processes 80169 TC1 87|88|128 ACTN1|A 7|1288|12 CTN2|CO 89|1294|1 L4A5|COL 295|1299| 4A6|COL5 1306|146 A1|COL7 2|1805|21 A1|COL8 99|2200|2 A1|COL9 201|2335| A3|COL15 3861|390 A1|VCAN| 9|3914|40 DPT|FBLN 01|4052|4 2|FBN1|F 053|4060| BN2|FN1| 4155|423 KRT14|LA GO 7|4632|49 MA3|LAM GO:00051 1 -5.48154 M1 1 0 Molecular 21 structural molecule activity -5.48154 1.976436 5.128457 24156 714 873 51 5.841924 0.793779 69|5010|5 B3|LMNB -3.3224 0 1 0 0 -22.6822 5.869416 98 Functions 354|7057| 1|LTBP1|L 7058|798 TBP2|LU 0|8483|10 M|MBP|M 216|1051 FAP2|MYL 6|10529|1 1|OGN|CL 0631|258 DN11|PLP 78|27295| 1|THBS1| 50853|54 THBS2|TF 221|5570 PI2|CILP|P 6|64129|7 RG4|FBLN 9812|798 5|NEBL|P 61|81027| OSTN|MX 83872|84 RA5|PDLI 467|8457 M3|VILL|S ACTN1|C 87|1289|2 OL5A1|FG 247|2335| R-HSA- Reactome F2|FN1|IT 1 -5.46925 M1 1 0 6 Syndecan interactions -5.46925 8.198549 7.246835 24156 27 873 8 0.91638 0.322501 3673|369 -3.31239 0 23 0 0 -7.4807 8.301031 3000170 Gene Sets GA2|ITGB 0|3691|70 3|ITGB4|T 57 HBS1 1062|383 CENPE|KI 2|9493|95 F11|KIF23 GO 85|9928|1 |KIF20B|KI GO:00058 Cellular 1004|241 F14|KIF2C 1 -5.44351 M1 1 0 20 kinesin complex -5.44351 5.534021 6.518362 24156 55 873 11 1.260023 0.37751 -3.28892 0 46 1 1 -5.44351 7.281606 71 Compone 37|26153| |KIF4A|KIF nts 54820|81 26A|NDE 930|3472 1|KIF18A| 40 KIF24 GO 655|1591| BMP7|CY GO:00332 1 -1.39849 M1 1 0 Biological 19 response to vitamin D -1.39849 3.074456 2.411893 24156 36 873 4 0.45819 0.22857 5179|642 P24A1|PE -0.29545 0 0 80 Processes 2 NK|SFRP1 GO 3280|461 HES1|MY GO:00424 inner ear auditory receptor cell 1 -1.39849 M1 1 0 Biological 19 -1.39849 3.074456 2.411893 24156 36 873 4 0.45819 0.22857 0|9497|11 CL|SLC4A -0.29545 0 0 91 differentiation Processes 7531 7|TMC1 CCN2|ITG 1490|367 A1|ITGA2| GO 2|3673|36 GO:00072 ITGB3|ITG 1 -1.39602 M1 1 0 Biological 19 integrin-mediated signaling pathway -1.39602 2.068793 2.145498 24156 107 873 8 0.91638 0.322501 90|3691|3 -0.29379 0 0 29 B4|LAMA Processes 909|5354| 3|PLP1|PR 5587 KD1 COL4A5| COL4A6| 1287|128 COL5A1| 8|1289|12 COL7A1| Canonical 94|1295|1 1 -5.34556 M198 M1 1 0 11 PID SYNDECAN 1 PATHWAY -5.34556 6.01524 6.592698 24156 46 873 10 1.145475 0.360151 COL8A1| -3.19992 0 5 0 0 -15.2617 12.29782 Pathways 299|1306| COL9A3| 4233|431 COL15A1| 2|4316 MET|MM P1|MMP7 655|2620| BMP7|GA 3280|106 S2|HES1|P GO GO:00085 31|54567| OSTN|DL 1 -1.39602 M1 1 0 Biological 19 regulation of Notch signaling pathway -1.39602 2.068793 2.145498 24156 107 873 8 0.91638 0.322501 -0.29379 0 0 93 81619|15 L4|TSPAN Processes 7285|441 14|PRAG1 478 |NRARP ACTC1|A CTN1|AC TN2|FHL3 70|87|88| |MYL1|PE 2275|463 CAM1|SC 2|5175|63 O1|TIMP4 41|7079|7 |TNNI1|T 135|7136| NNI2|TN 7139|714 GO NT2|TNN 0|10324|1 GO:00432 Cellular T3|KLHL4 1 -5.29557 M1 1 0 20 contractile fiber -5.29557 2.825883 5.446385 24156 235 873 24 2.749141 0.553399 0529|113 -3.15434 0 48 1 1 -5.29557 3.217454 92 Compone 1|NEBL|SY 46|27063| nts NPO|ANK 27295|29 RD1|PDLI 766|2978 M3|TMO 0|57159|7 D3|PARV 9912|916 B|TRIM54| 24|91977| PYROXD1 113146 |NEXN|M YOZ3|AH NAK2 ACTC1|A CTN1|AC 70|87|88| TN2|FHL3 2275|463 |MYL1|TI 2|7079|71 MP4|TNN 35|7136|7 I1|TNNI2| 139|7140| TNNT2|T GO 10324|10 NNT3|KL GO:00300 Cellular 529|1134 HL41|NEB 1 -5.28682 M1 1 0 20 sarcomere -5.28682 2.984031 5.510408 24156 204 873 22 2.520046 0.530463 -3.1489 0 48 0 0 -5.29557 3.217454 17 Compone 6|27063|2 L|SYNPO| nts 7295|297 ANKRD1| 66|29780| PDLIM3|T 57159|79 MOD3|PA 912|9162 RVB|TRIM 4|91977|1 54|PYROX 13146 D1|NEXN| MYOZ3|A HNAK2 ITPKA|NT 3706|491 RK3|TIAM 6|7074|11 GO 1|IL1RAPL GO:00991 141|2287 1 -1.39602 M1 1 0 Biological 19 regulation of postsynapse organization -1.39602 2.068793 2.145498 24156 107 873 8 0.91638 0.322501 1|NLGN1| -0.29379 0 0 75 1|23237|2 Processes ARC|SIPA 6037|347 1L1|LRRT 730 M1 CHRNA1| 1134|181 GO DRD5|ITG GO:00192 6|3673|49 1 -1.39049 M1 1 0 Biological 19 transmission of nerve impulse -1.39049 2.371723 2.225483 24156 70 873 6 0.687285 0.279617 A2|NTRK3 -0.28925 0 0 26 16|6328|1 Processes |SCN3A|C 0369 ACNG2 BRCA1|D 672|1789| GO NMT3B|S GO:00310 4089|508 1 -1.39049 M1 1 0 Biological 19 regulation of histone methylation -1.39049 2.371723 2.225483 24156 70 873 6 0.687285 0.279617 MAD4|PA -0.28925 0 0 60 1|8726|55 Processes X7|EED|RI 183 F1 CASP2|G 835|2620| GO AS2|INHB GO:00426 3624|431 1 -1.39049 M1 1 0 Biological 19 ovulation cycle -1.39049 2.371723 2.225483 24156 70 873 6 0.687285 0.279617 A|MMP7| -0.28925 0 0 98 6|5156|70 Processes PDGFRA| 79 TIMP4 EDN3|AU 1908|679 GO RKA|DLG GO:00517 0|9787|28 1 -1.39049 M1 1 0 Biological 19 positive regulation of nuclear division -1.39049 2.371723 2.225483 24156 70 873 6 0.687285 0.279617 AP5|RGC -0.28925 0 0 85 984|5120 Processes C|NUSAP 3|55023 1|PHIP ACTC1|A CTN1|AC 70|87|88| TN2|FHL3 2275|463 |MYL1|PE 2|5175|70 CAM1|TI 79|7135|7 MP4|TNN 136|7139| I1|TNNI2| 7140|103 TNNT2|T GO 24|10529| NNT3|KL GO:00444 Cellular 1 -5.23756 M1 1 0 20 contractile fiber part -5.23756 2.879694 5.435728 24156 221 873 23 2.634593 0.542066 11346|27 HL41|NEB -3.11142 0 48 0 0 -5.29557 3.217454 49 Compone 063|2729 L|SYNPO| nts 5|29766|2 ANKRD1| 9780|571 PDLIM3|T 59|79912| MOD3|PA 91624|91 RVB|TRIM 977|1131 54|PYROX 46 D1|NEXN| MYOZ3|A HNAK2 ACTC1|A CTN1|AC 70|87|88| TN2|CALB 794|1266| 2|CNN3|F 2275|262 HL3|GAS2 0|4632|71 |MYL1|TN 35|7136|7 NI1|TNNI 139|7140| 2|TNNT2| 7456|964 TNNT3|W 5|10360|1 IPF1|MIC 0529|107 AL2|NPM 88|11346| 3|NEBL|IQ 22998|23 GAP2|SY GO 237|2343 NPO|LIM GO:00156 Cellular 3|27145|2 1 -5.22675 M1 1 0 20 actin cytoskeleton -5.22675 2.14082 5.077374 24156 517 873 40 4.581901 0.707671 CH1|ARC| -3.10272 0 48 0 0 -5.29557 3.217454 29 Compone 7295|297 RHOQ|FIL nts 66|29780| IP1|PDLI 50853|53 M3|TMO 904|5444 D3|PARV 3|55706|5 B|VILL|MY 7565|576 O3A|ANL 19|60312| N|NDC1| 84687|84 KLHL14|S 952|9042 HROOM3 7|91624|9 |AFAP1|P 1977|925 PP1R9B|C 21|24617 GNL1|BM 6|359845 F|NEXN| MYOZ3|S EPHB1|EP 2047|204 HB2|GRIN 8|2902|37 1|ITPKA|TI GO 06|7074|1 GO:00488 AM1|IL1R 1 -1.38663 M1 1 0 Biological 19 dendrite morphogenesis -1.38663 1.88232 2.077729 24156 147 873 10 1.145475 0.360151 1141|228 -0.28619 0 0 13 APL1|NLG Processes 71|23237| N1|ARC|S 26037|85 IPA1L1|K 442 NDC1 ADORA2 A|CHRNA 135|1134| 1|GABRA 2555|255 GO 2|GABRA GO:00600 regulation of postsynaptic membrane 6|2557|25 1 -1.38663 M1 1 0 Biological 19 -1.38663 1.88232 2.077729 24156 147 873 10 1.145475 0.360151 3|GABRA -0.28619 0 0 78 potential 65|2890|2 Processes 4|GABRG 902|4208| 1|GRIA1| 22871 GRIN1|M EF2C|NLG ADORA2 A|AGTR2| 135|186|9 CD34|HT 47|3357|4 R2B|MBP| 155|5600| MAPK11| 8111|876 GO GPR68|RI GO:00507 7|10125|1 1 -1.38252 M1 1 0 Biological 19 positive regulation of protein secretion -1.38252 1.615772 1.984958 24156 274 873 16 1.832761 0.453972 PK2|RASG -0.28229 0 0 14 0631|230 Processes RP1|POST 86|27063| N|EXPH5| 28984|79 ANKRD1| 679|9412 RGCC|VT 1|114899 CN1|SYTL 4|C1QTN CDK6|HE 1021|328 S1|INHBA 0|3624|42 |MEOX1|P GO 22|5156|6 GO:00022 hematopoietic progenitor cell DGFRA|SF 1 -1.37701 M1 1 0 Biological 19 -1.37701 1.811733 2.044382 24156 168 873 11 1.260023 0.37751 422|7153| -0.27751 0 0 44 differentiation RP1|TOP2 Processes 7520|104 A|XRCC5| 13|10468| YAP1|FST| 54443 ANLN ADORA2 GO 136|1816| GO:00312 B|DRD5|G 1 -1.37675 M1 1 0 Biological 19 regulation of cyclase activity -1.37675 2.610387 2.272604 24156 53 873 5 0.572738 0.255402 2913|488 -0.27751 0 0 79 RM3|NPR Processes 3|729230 3|CCR2 ACTC1|A CTN1|AC 70|87|88| TN2|FHL3 2275|463 |MYL1|SC 2|6341|70 O1|TIMP4 79|7135|7 |TNNI1|T 136|7139| NNI2|TN 7140|103 NT2|TNN GO 24|10529| T3|KLHL4 GO:00300 Cellular 1 -5.14009 M1 1 0 20 myofibril -5.14009 2.841127 5.36055 24156 224 873 23 2.634593 0.542066 11346|27 1|NEBL|SY -3.02937 0 48 0 0 -5.29557 3.217454 16 Compone 063|2729 NPO|ANK nts 5|29766|2 RD1|PDLI 9780|571 M3|TMO 59|79912| D3|PARV 91624|91 B|TRIM54| 977|1131 PYROXD1 46 |NEXN|M YOZ3|AH NAK2 983|4751| CDK1|NE 5116|865 K2|PCNT| 5|9662|98 DYNLL1|C 14|10733| EP135|SFI R-HSA- Reactome Recruitment of mitotic centrosome proteins 1 -5.13685 M1 1 0 6 -5.13685 4.386724 5.948449 24156 82 873 13 1.489118 0.40992 54820|55 1|PLK4|N -3.02937 0 12 0 0 -10.0997 6.06468 380270 Gene Sets and complexes 125|5583 DE1|CEP1 5|79441|8 92|CENPJ| 0184|121 HAUS3|C 441 EP290|NE 983|4751| CDK1|NE 5116|865 K2|PCNT| 5|9662|98 DYNLL1|C 14|10733| EP135|SFI R-HSA- Reactome 1 -5.13685 M1 1 0 6 Centrosome maturation -5.13685 4.386724 5.948449 24156 82 873 13 1.489118 0.40992 54820|55 1|PLK4|N -3.02937 0 12 0 0 -10.0997 6.06468 380287 Gene Sets 125|5583 DE1|CEP1 5|79441|8 92|CENPJ| 0184|121 HAUS3|C 441 EP290|NE BIRC5|CD 332|983|1 K1|CENPE 062|3832| |KIF11|AU GO 6790|241 RKA|KIF4 GO:00058 Cellular 37|51203| 1 -5.13168 M1 1 0 20 spindle microtubule -5.13168 5.158833 6.193087 24156 59 873 11 1.260023 0.37751 A|NUSAP -3.02623 0 8 0 0 -11.3911 5.158833 76 Compone 81930|85 1|KIF18A| nts 459|1267 CEP295|C 31|22115 CSAP|SKA 0 3 CCND2|C 894|983|1 DK1|CDK 021|1030| 6|CDKN2 1870|417 B|E2F2|M 5|4998|49 CM6|ORC 99|5558|6 1|ORC2|P R-HSA- Reactome 1 -5.1161 M1 1 0 6 Mitotic G1 phase and G1/S transition -5.1161 3.342697 5.554328 24156 149 873 18 2.061856 0.480948 241|7029| RIM2|RR -3.01266 0 20 0 0 -7.69554 7.546392 453279 Gene Sets 7153|746 M2|TFDP 5|8317|83 2|TOP2A| 18|9134|5 WEE1|CD 5388|286 C7|CDC4 826 5|CCNE2| MCM10|L CRHBP|D GO 1393|178 GO:00422 NMT3B|D 1 -1.37675 M1 1 0 Biological 19 response to cocaine -1.37675 2.610387 2.272604 24156 53 873 5 0.572738 0.255402 9|1816|70 -0.27751 0 0 20 RD5|TIAM Processes 74|8772 1|FADD BRCA1|C CND2|CD 672|894|1 K6|COL4 021|1287| A5|COL4 1288|129 A6|COL9 9|1385|22 A3|CREB1 47|2277|2 |FGF2|VE 324|2335| GFD|FLT4| 2846|367 FN1|LPAR 2|3673|36 4|ITGA1|I KEGG 90|3691|3 TGA2|ITG 1 -5.09904 hsa04151 M1 1 0 24 PI3K-Akt signaling pathway -5.09904 2.427202 5.147229 24156 342 873 30 3.436426 0.616528 -2.99961 0 23 0 0 -7.4807 8.301031 Pathway 909|3914| B3|ITGB4| 4233|515 LAMA3|L 6|5228|55 AMB3|ME 63|7057|7 T|PDGFR 058|9134| A|PGF|PR 9180|299 KAA2|TH 41|56034| BS1|THBS 131873|2 2|CCNE2| 84217 OSMR|PK N3|PDGF C|COL6A VCAN|UG 1462|735 DH|HS2S GO 8|9653|23 GO:00060 T1|SULF1| 1 -1.37487 M1 1 0 Biological 19 proteoglycan metabolic process -1.37487 2.1763 2.152749 24156 89 873 7 0.801833 0.301847 213|5136 -0.27623 0 0 29 CHST15|C Processes 3|55790|1 SGALNAC 33584 T1|EGFLA 10051|10 SMC4|SM CORUM:1 1 -5.08464 M1 1 0 CORUM 33 Condensin I complex -5.08464 22.13608 9.15236 24156 5 873 4 0.45819 0.22857 592|2339 C2|NCAP -2.99408 0 36 0 0 -6.06241 22.13608 0 7|64151 H|NCAPG 10051|10 SMC4|SM CORUM:1 1 -5.08464 M1 1 0 CORUM 33 Condensin I complex -5.08464 22.13608 9.15236 24156 5 873 4 0.45819 0.22857 592|2339 C2|NCAP -2.99408 0 36 0 0 -6.06241 22.13608 57 7|64151 H|NCAPG 10051|10 SMC4|SM CORUM:1 1 -5.08464 M1 1 0 CORUM 33 Condensin I complex -5.08464 22.13608 9.15236 24156 5 873 4 0.45819 0.22857 592|2339 C2|NCAP -2.99408 0 36 0 0 -6.06241 22.13608 67 7|64151 H|NCAPG BMP7|DA B1|DUSP7 655|1600| |EPHB2|M 1849|204 ECOM|LIF 8|2122|39 |SMAD4| 76|4089|4 MET|SERP 233|5270| INE2|PRK 5563|579 AA2|PTPR 5|6095|63 J|RORA|C 87|6422|6 XCL12|SF GO 425|7057| RP1|SFRP GO:19025 negative regulation of intracellular signal 1 -1.3729 M1 1 0 Biological 19 -1.3729 1.405312 1.897931 24156 571 873 29 3.321879 0.606525 7078|795 5|THBS1| -0.27465 0 0 32 transduction Processes 7|9938|11 TIMP3|EP 072|2282 M2A|ARH 1|55031|8 GAP25|D 4952|114 USP14|RA 899|1262 SA3|USP4 82|14368 7|CGNL1| 6|154743| C1QTNF3 219790|6 |TNFAIP8 52968 L1|SESN3| BMT2|RT KN2|CAS COL4A5| 1287|128 COL4A6| R-HSA- Reactome 8|1294|39 1 -5.08172 M1 1 0 6 Anchoring fibril formation -5.08172 11.06804 7.552734 24156 15 873 6 0.687285 0.279617 COL7A1|L -2.99407 0 5 0 0 -15.2617 12.29782 2214320 Gene Sets 09|3914|7 AMA3|LA 093 MB3|TLL2 AGTR2|F 186|2247| GF2|FLT4| 2324|367 ITGA2|IT 3|3690|42 GB3|MEF 08|4233|5 2C|MET|P GO 587|5629| GO:00106 RKD1|PR 1 -1.37036 M1 1 0 Biological 19 regulation of epithelial cell migration -1.37036 1.583811 1.960267 24156 297 873 17 1.947308 0.467671 6915|705 -0.27272 0 0 32 OX1|TBX Processes 7|28984|5 A2R|THBS 4567|573 1|RGCC|D 81|57608| LL4|RHOJ| 79812|14 JCAD|MM 7372 RN2|CCB COMT|CR 1312|138 EB1|CRHB 5|1393|18 P|DRD5|E 16|2048|2 PHB2|GRI 890|2902| A1|GRIN1 GO 3269|420 |HRH1|M GO:00508 1 -1.37036 M1 1 0 Biological 19 cognition -1.37036 1.583811 1.960267 24156 297 873 17 1.947308 0.467671 8|4885|70 EF2C|NPT -0.27272 0 0 90 Processes 54|11346| X2|TH|SY 23237|84 NPO|ARC 687|1394 |PPP1R9B 11|15155 |PTCHD1| 6|164312 GPR155|L RRN4 720|899|1 C4A|CCN 114|1356| F|CHGB|C 1462|220 P|VCAN|F 0|2335|40 BN1|FN1| 08|4052|5 LMO7|LT GO 179|5931| BP1|PENK GO:00436 1 -1.36967 M1 1 0 Biological 19 post-translational protein modification -1.36967 1.520335 1.936911 24156 364 873 20 2.290951 0.50637 10324|10 |RBBP7|KL -0.27222 0 0 87 Processes 491|5151 HL41|CRT 4|56929|7 AP|DTL|F 9075|801 EM1C|DS 76|91851| CC1|SPSB 122769|1 1|CHRDL 40462 1|LRR1|AS ACTC1|C 70|983|10 DK1|CDO GO 36|1393|2 GO:00454 1|CRHBP| 1 -1.36854 M1 1 0 Biological 19 response to ethanol -1.36854 1.945554 2.076939 24156 128 873 9 1.030928 0.341867 902|4916| -0.27129 0 0 71 GRIN1|NT Processes 5179|691 RK3|PENK 5|7054 |TBXA2R| ACTN2|E 88|2048|1 GO PHB2|CA GO:20012 positive regulation of cation channel 0369|232 1 -1.36504 M1 1 0 Biological 19 -1.36504 2.338319 2.186787 24156 71 873 6 0.687285 0.279617 CNG2|AR -0.2691 0 0 59 activity 37|12675 Processes C|LRRC38 5|729230 |CCR2 BMP7|DA 655|1600| B1|EPHB2 2048|220 |FBN1|HE 0|3280|40 S1|SMAD 89|4916|4 4|NTRK3| 974|5744| OMG|PT GO 9423|972 GO:00107 HLH|NTN 1 -1.36476 M1 1 0 Biological 19 negative regulation of cell development -1.36476 1.537228 1.937522 24156 342 873 19 2.176403 0.493838 3|10631|2 -0.2691 0 0 21 1|SEMA3 Processes 2871|308 E|POSTN| 12|56963| NLGN1|S 57540|15 OX8|RGM 7285|259 A|DISP3|P 266|3598 RAG1|AS 45 PM|RFLN GO EPHB1|CX GO:00160 2047|638 1 -1.36205 M1 1 0 Biological 19 detection of temperature stimulus -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 CL12|CXC -0.2691 0 0 48 7|7852 Processes R4 GO PAX7|PR GO:00215 5081|562 1 -1.36205 M1 1 0 Biological 19 dorsal spinal cord development -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 OX1|LMO -0.2691 0 0 16 9|8543 Processes 4 GO PROX1|R GO:00215 5629|609 1 -1.36205 M1 1 0 Biological 19 cell differentiation in hindbrain -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 ORA|KND -0.2691 0 0 33 5|85442 Processes C1 COL4A5| 1287|128 COL4A6| 8|1306|39 COL15A1| Canonical 09|3914|9 LAMA3|L 1 -4.99712 M5887 M1 1 0 11 NABA BASEMENT MEMBRANES -4.99712 6.225773 6.404999 24156 40 873 9 1.030928 0.341867 -2.92844 0 5 0 0 -15.2617 12.29782 Pathways 423|8387 AMB3|NT 2|131873| N1|HMC 284217 N1|COL6 A6|LAMA GO GO:00456 3624|397 INHBA|LIF 1 -1.36205 M1 1 0 Biological 19 regulation of macrophage differentiation -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 -0.2691 0 0 49 6|8772 |FADD Processes GO 4208|916 MEF2C|B GO:00456 positive regulation of myoblast 1 -1.36205 M1 1 0 Biological 19 -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 53|20215 OC|RANB -0.2691 0 0 63 differentiation Processes 1 P3L 983|4751| CDK1|NE 5116|865 K2|PCNT| 5|9662|98 DYNLL1|C 14|10733| EP135|SFI R-HSA- Reactome Anchoring of the basal body to the plasma 54820|55 1|PLK4|N 1 -4.94359 M1 1 0 6 -4.94359 3.952872 5.671776 24156 98 873 14 1.603666 0.425147 -2.88045 0 12 0 0 -10.0997 6.06468 5620912 Gene Sets membrane 125|5583 DE1|CEP1 5|79441|8 92|CENPJ| 0184|121 HAUS3|C 441|3472 EP290|NE 40 DD1|KIF2 GO EPHB1|CX GO:00509 2047|638 1 -1.36205 M1 1 0 Biological 19 sensory perception of temperature stimulus -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 CL12|CXC -0.2691 0 0 51 7|7852 Processes R4 COL4A5| COL4A6| 1287|128 COL5A1| 8|1289|12 GO COL7A1| GO:00300 extracellular matrix structural constituent 94|1295|1 1 -4.90355 M1 1 0 Molecular 21 -4.90355 6.073925 6.296273 24156 41 873 9 1.030928 0.341867 COL8A1| -2.84571 0 5 0 0 -15.2617 12.29782 20 conferring tensile strength 299|1306| Functions COL9A3| 84570|13 COL15A1| 1873 COL25A1| COL6A6 GO AGTR2|H GO:00510 positive regulation of nitric-oxide synthase 186|3357| 1 -1.36205 M1 1 0 Biological 19 -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 TR2B|NPR -0.2691 0 0 00 activity 4883 Processes 3 GO GO:00600 947|3690| CD34|ITG 1 -1.36205 M1 1 0 Biological 19 angiogenesis involved in wound healing -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 -0.2691 0 0 55 7852 B3|CXCR4 Processes GO GPR68|SL GO:00714 8111|109 1 -1.36205 M1 1 0 Biological 19 cellular response to pH -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 C38A3|H -0.2691 0 0 67 91|84329 Processes VCN1 GO GO:00901 regulation of branching involved in ureteric 186|1073 AGTR2|SI 1 -1.36205 M1 1 0 Biological 19 -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 -0.2691 0 0 89 bud morphogenesis 6|30812 X2|SOX8 Processes GO HIC1|PM GO:19017 positive regulation of signal transduction 3090|536 1 -1.36205 M1 1 0 Biological 19 -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 AIP1|ANK -0.2691 0 0 98 by p53 class mediator 6|27063 Processes RD1 ACTN1|F 87|2247|2 GF2|FN1| 335|3909| Canonical LAMA3|C 1 -4.86334 M165 M1 1 0 11 PID SYNDECAN 4 PATHWAY -4.86334 6.917526 6.48607 24156 32 873 8 0.91638 0.322501 6387|705 -2.81462 0 23 0 0 -7.4807 8.301031 Pathways XCL12|TH 7|7852|28 BS1|CXCR 4217 4|LAMA1 GO 23433|91 RHOQ|PK GO:19030 negative regulation of protein localization 1 -1.36205 M1 1 0 Biological 19 -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 461|1315 DCC|LRR -0.2691 0 0 77 to plasma membrane Processes 78 C15 GO 1816|291 DRD5|GR GO:00457 1 -1.36094 M1 1 0 Biological 19 regulation of adenylate cyclase activity -1.36094 2.991362 2.347268 24156 37 873 4 0.45819 0.22857 3|4883|72 M3|NPR3| -0.2691 0 0 61 Processes 9230 CCR2 GO 2277|642 VEGFD|SF GO:00715 1 -1.36094 M1 1 0 Biological 19 dopaminergic neuron differentiation -1.36094 2.991362 2.347268 24156 37 873 4 0.45819 0.22857 2|7074|34 RP1|TIAM -0.2691 0 0 42 Processes 0419 1|RSPO2 FGF2|PD GO 2247|515 GO:00902 GFRA|PRK 1 -1.36094 M1 1 0 Biological 19 positive regulation of lipid kinase activity -1.36094 2.991362 2.347268 24156 37 873 4 0.45819 0.22857 6|5587|38 -0.2691 0 0 18 D1|TNFAI Processes 8121 P8L3 NFATC1|T GO 4772|713 GO:19053 NFRSF1A| 1 -1.36094 M1 1 0 Biological 19 semi-lunar valve development -1.36094 2.991362 2.347268 24156 37 873 4 0.45819 0.22857 2|7133|54 -0.2691 0 0 14 TNFRSF1 Processes 567 B|DLL4 AGTR2|B 186|635|1 HMT|CHA 103|1312| T|COMT|L 3931|532 CAT|PLA2 GO 1|7054|26 GO:00971 G4A|TH| 1 -1.36086 M1 1 0 Biological 19 ammonium ion metabolic process -1.36086 1.704793 1.99107 24156 211 873 13 1.489118 0.40992 002|2995 -0.2691 0 0 64 MOXD1| Processes 8|55349|8 DMGDH| 3933|171 CHDH|H 586|2856 DAC10|A 71 BHD3|RN 86|1600|5 ACTL6A| GO 081|5629| DAB1|PA GO:00215 1 -1.35616 M1 1 0 Biological 19 spinal cord development -1.35616 2.030833 2.088634 24156 109 873 8 0.91638 0.322501 5992|854 X7|PROX -0.26501 0 0 10 Processes 3|8726|54 1|RFX4|L 567 MO4|EED CCND2|C 894|899|9 CNF|CCN GO 01|983|10 G2|CDK1| GO:00003 Cellular cyclin-dependent protein kinase 1 -4.81288 M1 1 0 20 -4.81288 5.929308 6.19109 24156 42 873 9 1.030928 0.341867 21|1164|9 CDK6|CKS -2.77982 0 37 0 0 -6.01116 5.929308 07 Compone holoenzyme complex 133|9134| 2|CCNB2| nts 85417 CCNE2|C CNB3 XIAP|BMP 331|655|4 7|SMAD4| 089|4090| SMAD5|T Canonical 10454|10 1 -4.81288 M181 M1 1 0 11 PID BMP PATHWAY -4.81288 5.929308 6.19109 24156 42 873 9 1.030928 0.341867 AB1|FST|R -2.77982 0 55 0 0 -4.87217 18.44674 Pathways 468|5696 GMA|SM 3|64750|9 URF2|CH 1851 RDL1 4175|436 MCM6|M 1|7153|75 RE11|TOP GO GO:00325 20|54821| 2A|XRCC5 1 -1.35616 M1 1 0 Biological 19 DNA duplex unwinding -1.35616 2.030833 2.088634 24156 109 873 8 0.91638 0.322501 -0.26501 0 0 08 79075|80 |ERCC6L| Processes 119|2543 DSCC1|PI 94 F1|MCM9 COL4A5| 1287|128 COL4A6| 8|1289|12 COL5A1| 99|1462|2 COL9A3| R-HSA- Reactome 335|3673| VCAN|FN 1 -4.76911 M1 1 0 6 ECM proteoglycans -4.76911 4.368964 5.695948 24156 76 873 12 1.37457 0.394068 -2.73946 0 23 0 0 -7.4807 8.301031 3000178 Gene Sets 3690|390 1|ITGA2|I 9|4060|13 TGB3|LA 1873|284 MA3|LUM 217 |COL6A6| LAMA1 1385|491 CREB1|NT 6|6258|70 RK3|RXRG GO GO:00325 75|8854|1 |TIE1|ALD 1 -1.35616 M1 1 0 Biological 19 response to retinoic acid -1.35616 2.030833 2.088634 24156 109 873 8 0.91638 0.322501 -0.26501 0 0 26 0413|549 H1A2|YA Processes 97|33947 P1|TESC|B 9 RINP3 AGTR2|C 186|983|1 DK1|ECT2 894|3838| |KPNA2|K GO 3841|107 GO:00066 PNA5|SIX 1 -1.35331 M1 1 0 Biological 19 protein import into nucleus -1.35331 1.857054 2.031999 24156 149 873 10 1.145475 0.360151 36|29969| -0.26236 0 0 06 2|MDFIC| Processes 51715|84 RAB23|EF 455|1441 CAB7|PRI 65 CKLE1 ALDH1A3 220|1545| |CYP1B1| GO 1583|885 GO:00343 CYP11A1| 1 -1.35284 M1 1 0 Biological 19 primary alcohol metabolic process -1.35284 2.152119 2.120351 24156 90 873 7 0.801833 0.301847 4|9249|95 -0.26228 0 0 08 ALDH1A2 Processes 63|15750 |DHRS3|H 6 6PD|RDH ADORA2 A|CDH5|C OL4A5|C 135|1003| OL5A1|C 1287|128 OL9A3|C 9|1299|13 REB1|DUS 85|1849|2 P7|FGF2| 247|2277| VEGFD|FL 2324|233 T4|FN1|IT 5|3673|36 GA2|ITGB 90|3909|3 3|LAMA3| 914|4208| LAMB3|M 4233|491 EF2C|MET 6|5125|51 R-HSA- Reactome |NTRK3|P 1 -4.70687 M1 1 0 6 Signaling by Receptor Tyrosine Kinases -4.70687 2.077992 4.745329 24156 506 873 38 4.352806 0.690579 56|5228|5 -2.68395 0 23 0 0 -7.4807 8.301031 9006934 Gene Sets CSK5|PD 600|5795| GFRA|PG 6387|645 F|MAPK1 6|6692|70 1|PTPRJ|C 57|7058|7 XCL12|SH 074|8483| 3GL2|SPI 10413|23 NT1|THBS 237|2376 1|THBS2| 8|55824|5 TIAM1|CI 6034|647 LP|YAP1| 59|13187 ARC|FLRT 3|284217 2|PAG1|P DGFC|TN S3|COL6A BIRC5|CE 332|1062| NPE|CNN 1266|262 3|GAS2|KI 0|3832|70 F11|TIAM 74|9493|9 1|KIF23|KI 585|9928| F20B|KIF1 11004|11 4|KIF2C|K 104|2413 ATNA1|KI GO 7|26153|5 F4A|KIF26 GO:00080 1 -4.69734 M1 1 0 Molecular 21 microtubule binding -4.69734 2.604245 4.986823 24156 255 873 24 2.749141 0.553399 1203|548 A|NUSAP -2.67609 0 8 0 0 -11.3911 5.158833 17 Functions 20|56890| 1|NDE1| 57159|80 MDM1|TR 184|8193 IM54|CEP 0|85459|1 290|KIF18 26731|24 A|CEP295 6176|347 |CCSAP|G 240|4407 AS2L2|KIF 38 24|MAP1 LC3C BMP7|CD 655|1021| K6|FBN2| 2201|409 GO SMAD5| GO:00456 0|4208|55 1 -1.35061 M1 1 0 Biological 19 regulation of osteoblast differentiation -1.35061 1.930472 2.051822 24156 129 873 9 1.030928 0.341867 MEF2C|P -0.26024 0 0 67 87|6422|1 Processes RKD1|SFR 17581|20 P1|TWIST 2151 2|RANBP ADORA2 A|CDH9|C 135|1007| DH10|CH 1008|113 RM3|CHR 1|1134|20 NA1|EPH GO 48|2556|2 B2|GABR GO:00990 Cellular integral component of postsynaptic 1 -4.67369 M1 1 0 20 -4.67369 3.547449 5.348493 24156 117 873 15 1.718213 0.439813 557|2890| A3|GABR -2.65575 0 58 1 1 -4.67369 3.739203 55 Compone membrane 2902|291 A4|GRIA1| nts 3|4916|10 GRIN1|GR 369|2287 M3|NTRK 1|347730 3|CACNG 2|NLGN1| LRRTM1 CREB1|VE 1385|227 GFD|FLT4| Canonical 7|2324|23 1 -4.67046 M274 M1 1 0 11 PID LYMPH ANGIOGENESIS PATHWAY -4.67046 7.747629 6.536191 24156 25 873 7 0.801833 0.301847 FN1|ITGA -2.65417 0 59 1 1 -4.67046 7.747629 Pathways 35|3672|3 1|ITGA2| 673|5600 MAPK11 186|1312| AGTR2|C GO GO:00065 7054|260 OMT|TH| 1 -1.34712 M1 1 0 Biological 19 catecholamine metabolic process -1.34712 2.562047 2.225131 24156 54 873 5 0.572738 0.255402 -0.25792 0 0 84 02|28567 MOXD1|R Processes 1 NF180 186|1312| AGTR2|C GO GO:00097 catechol-containing compound metabolic 7054|260 OMT|TH| 1 -1.34712 M1 1 0 Biological 19 -1.34712 2.562047 2.225131 24156 54 873 5 0.572738 0.255402 -0.25792 0 0 12 process 02|28567 MOXD1|R Processes 1 NF180 ACTN1|C 87|1003|1 DH5|CDH 005|1007| 7|CDH9|C 1008|100 DH10|CD R-HSA- Reactome 9|3691|38 H11|ITGB 1 -4.63345 M1 1 0 6 Cell junction organization -4.63345 3.952872 5.464665 24156 91 873 13 1.489118 0.40992 -2.62207 0 32 0 0 -6.28754 6.917526 446728 Gene Sets 61|3909|3 4|KRT14|L 914|5010| AMA3|LA 29780|84 MB3|CLD 612 N11|PAR VB|PARD 2491|234 CENPI|IT CORUM:7 21|55839| GB3BP|CE 1 -4.62928 M1 1 0 CORUM 33 CENP-H-I complex -4.62928 12.57732 7.436729 24156 11 873 5 0.572738 0.255402 -2.61952 0 31 0 0 -6.31644 12.57732 394 91687|40 NPN|CEN 1541 PL|CENPP SERPINE2 GO 5270|705 GO:00316 |THBS1|P 1 -1.34712 M1 1 0 Biological 19 zymogen activation -1.34712 2.562047 2.225131 24156 54 873 5 0.572738 0.255402 7|8492|87 -0.25792 0 0 38 RSS12|RIP Processes 67|8772 K2|FADD GABRA2| GABRA3| 2555|255 GABRA4| 6|2557|25 GABRG1| GO 65|5167|5 GO:00156 ENPP1|E 1 -1.34619 M1 1 0 Biological 19 inorganic anion transport -1.34619 1.790418 2.002598 24156 170 873 11 1.260023 0.37751 169|5593| -0.25738 0 0 98 NPP3|PRK Processes 9497|561 G2|SLC4A 72|83959| 7|ANKH|S 196527 LC4A11|A NO6 ADORA2 A|ADORA 135|136|2 2B|FGF2| 247|2277| VEGFD|FL 2324|284 T4|LPAR4| 6|2902|36 GRIN1|IT 90|4233|5 GB3|MET| 156|5228| PDGFRA| KEGG 1 -4.57507 hsa04015 M1 1 0 24 Rap1 signaling pathway -4.57507 2.76701 4.979932 24156 210 873 21 2.405498 0.518571 5587|560 PGF|PRK -2.57015 0 60 1 1 -4.57507 9.223368 Pathway 0|7057|70 D1|MAPK 74|25780| 11|THBS1 26037|56 |TIAM1|R 034|5756 ASGRP3|S 8|84612|9 IPA1L1|P 1860 DGFC|SIP A1L2|PAR D6B|CAL BMP7|CD 655|1021| K6|GAS2| 2620|328 HES1|TIM 0|7079|97 GO P4|DLGA GO:00072 87|10631| 1 -1.34469 M1 1 0 Biological 19 Notch signaling pathway -1.34469 1.738436 1.983955 24156 191 873 12 1.37457 0.394068 P5|POST -0.25627 0 0 19 54567|81 Processes N|DLL4|T 619|1138 SPAN14| 78|15728 DTX2|PRA 5|441478 G1|NRAR BIRC5|BR CA1|BRC 332|672|6 A2|CENP 75|1062|1 E|CNN3|G 266|2620| AS2|KIF11 3832|707 |TIAM1|KI 4|9493|95 F23|KIF20 85|9928|1 B|KIF14|P 0891|110 PARGC1A 04|11104| |KIF2C|KA 24137|26 GO TNA1|KIF GO:00156 153|5120 1 -4.55716 M1 1 0 Molecular 21 tubulin binding -4.55716 2.312487 4.768484 24156 347 873 29 3.321879 0.606525 4A|KIF26 -2.5558 0 8 0 0 -11.3911 5.158833 31 3|54820|5 Functions A|NUSAP 5835|568 1|NDE1|C 90|57159| ENPJ|MD 80184|81 M1|TRIM 930|8545 54|CEP29 9|126731| 0|KIF18A| 135138|2 CEP295|C 46176|34 CSAP|PA 7240|440 CRG|GAS 738 2L2|KIF24 |MAP1LC FAS|COM 355|1312| T|PMAIP1 5366|556 |PRKAA2| 3|5587|64 PRKD1|SF GO GO:00425 22|10891| RP1|PPAR 1 -1.34469 M1 1 0 Biological 19 response to starvation -1.34469 1.738436 1.983955 24156 191 873 12 1.37457 0.394068 -0.25627 0 0 94 10991|81 GC1A|SLC Processes 788|1436 38A3|NU 86|15474 AK2|SESN 3|440738 3|BMT2| MAP1LC3 ADORA2 A|ADORA 2B|AGTR2 135|136|1 |CD34|CR 86|947|13 EB1|EDN3 85|1908|3 |HTR2B|I 357|3624| NHBA|SM 4089|415 AD4|MBP| 5|5600|63 GO MAPK11| GO:00510 87|8111|8 1 -1.33442 M1 1 0 Biological 19 positive regulation of secretion -1.33442 1.459661 1.875492 24156 436 873 23 2.634593 0.542066 CXCL12|G -0.24678 0 0 47 767|1012 Processes PR68|RIP 5|10631|2 K2|RASGR 2871|230 P1|POST 86|27063| N|NLGN1 28984|79 |EXPH5|A 679|9412 NKRD1|R 1|114899 GCC|VTC N1|SYTL4| C1QTNF3 ADORA2 136|1490| B|CCN2|E 2047|212 PHB1|ME 2|2324|64 COM|FLT GO GO:00072 22|7074|8 4|SFRP1|T 1 -1.33382 M1 1 0 Biological 19 JNK cascade -1.33382 1.688786 1.955131 24156 213 873 13 1.489118 0.40992 -0.24637 0 0 54 325|8767| IAM1|FZD Processes 10125|10 8|RIPK2|R 454|2996 ASGRP1|T 9|79444 AB1|MDFI C|BIRC7 1490|423 CCN2|ME GO 3|6422|22 T|SFRP1|P GO:00514 1 -1.3312 M1 1 0 Biological 19 regulation of stress fiber assembly -1.3312 2.128469 2.088376 24156 91 873 7 0.801833 0.301847 843|2299 PM1E|LIM -0.24415 0 0 92 Processes 8|28984|8 CH1|RGC 4952 C|CGNL1 ADORA2 A|XIAP|BI 135|331|3 RC5|C4A| 32|720|12 COL7A1| 94|2619|5 GAS1|SER 270|6341| PINE2|SC 6692|705 O1|SPINT GO 7|7078|70 GO:00458 1|THBS1| 1 -1.32932 M1 1 0 Biological 19 negative regulation of proteolysis -1.32932 1.50381 1.885831 24156 368 873 20 2.290951 0.50637 79|7980|9 -0.24264 0 0 61 TIMP3|TI Processes 232|5503 MP4|TFPI 1|79444|8 2|PTTG1| 0760|117 USP47|BI 166|1248 RC7|ITIH5 57|14090 |WFIKKN1 2 |WFIKKN2 |R3HDML GO 5395|915 PMS2|EX GO:00062 1 -1.32475 M1 1 0 Biological 19 mismatch repair -1.32475 2.912642 2.284789 24156 38 873 4 0.45819 0.22857 6|83933|2 O1|HDAC -0.23923 0 0 98 Processes 54394 10|MCM9 PMAIP1|P GO 5366|556 GO:00421 RKAA2|N 1 -1.32475 M1 1 0 Biological 19 cellular response to glucose starvation -1.32475 2.912642 2.284789 24156 38 873 4 0.45819 0.22857 3|81788|1 -0.23923 0 0 49 UAK2|SES Processes 43686 N3 GO 983|8317| CDK1|CD GO:00457 1 -1.32475 M1 1 0 Biological 19 positive regulation of DNA replication -1.32475 2.912642 2.284789 24156 38 873 4 0.45819 0.22857 80169|14 C7|CTC1| -0.23923 0 0 40 Processes 4455 E2F7 CAMK2A| 815|2239| GPC4|FZ 2535|477 D2|NFAT GO GO:00355 2|6422|64 C1|SFRP1| 1 -1.3208 M1 1 0 Biological 19 non-canonical Wnt signaling pathway -1.3208 1.832457 1.986967 24156 151 873 10 1.145475 0.360151 -0.23909 0 0 67 25|7074|8 SFRP5|TIA Processes 325|6475 M1|FZD8| 0|144165 SMURF2| PRICKLE1 ACTC1|A 70|88|463 CTN2|MY 2|7135|71 L1|TNNI1| R-HSA- Reactome 1 -4.46004 M1 1 0 6 Striated Muscle Contraction -4.46004 6.148912 5.986448 24156 36 873 8 0.91638 0.322501 36|7139|7 TNNI2|TN -2.47506 0 61 0 0 -4.53228 18.44674 390522 Gene Sets 140|2976 NT2|TNN 6 T3|TMOD 3 ACTN2|M GO 88|9645|2 GO:00300 ICAL2|TM 1 -1.31829 M1 1 0 Biological 19 actin filament depolymerization -1.31829 2.515464 2.178716 24156 55 873 5 0.572738 0.255402 9766|508 -0.23909 0 0 42 OD3|VILL| Processes 53|84687 PPP1R9B ADORA2 A|CDH9|C 135|1007| DH10|CH 1008|113 RM3|CHR 1|1134|20 NA1|EPH GO 48|2556|2 B2|GABR GO:00989 Cellular intrinsic component of postsynaptic 1 -4.45628 M1 1 0 20 -4.45628 3.402062 5.150415 24156 122 873 15 1.718213 0.439813 557|2890| A3|GABR -2.47323 0 58 0 0 -4.67369 3.739203 36 Compone membrane 2902|291 A4|GRIA1| nts 3|4916|10 GRIN1|GR 369|2287 M3|NTRK 1|347730 3|CACNG 2|NLGN1| LRRTM1 CDO1|VC GO 1036|146 GO:00442 AN|LUM| 1 -1.31829 M1 1 0 Biological 19 sulfur compound catabolic process -1.31829 2.515464 2.178716 24156 55 873 5 0.572738 0.255402 2|4060|49 -0.23909 0 0 73 OGN|KER Processes 69|11081 A BIRC5|CE 332|1062| NPE|KIF1 3832|679 1|AURKA| 0|8655|94 DYNLL1|K 93|9585|9 GO IF23|KIF2 928|1100 GO:00058 Cellular 0B|KIF14| 1 -4.42834 M1 1 0 20 microtubule associated complex -4.42834 3.094683 5.016368 24156 152 873 17 1.947308 0.467671 4|24137|2 -2.44833 0 46 0 0 -5.44351 7.281606 75 Compone KIF2C|KIF 6153|548 nts 4A|KIF26 20|55112| A|NDE1| 57159|79 WDR60|T 441|8193 RIM54|H 0|347240 AUS3|KIF HES1|ME 3280|420 GO F2C|NFAT GO:00511 8|4772|69 1 -1.31576 M1 1 0 Biological 19 smooth muscle cell differentiation -1.31576 2.274255 2.111318 24156 73 873 6 0.687285 0.279617 C1|ZEB1| -0.23909 0 0 45 35|10266| Processes RAMP2|M 93649 YOCD MEF2C|P 4208|512 CSK5|PIT 5|5308|64 GO X2|STIL|A GO:00098 91|8854|9 1 -1.31548 M1 1 0 Biological 19 determination of bilateral symmetry -1.31548 1.900999 2.002256 24156 131 873 9 1.030928 0.341867 LDH1A2| -0.23909 0 0 55 645|5109 Processes MICAL2|I 8|161582| FT52|DN 339829 AAF4|CC GO GO:00015 3624|515 INHBA|P 1 -1.31491 M1 1 0 Biological 19 luteinization -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 53 6 DGFRA Processes GO GO:00076 1312|139 COMT|PT 1 -1.31491 M1 1 0 Biological 19 short-term memory -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 14 411 CHD1 Processes GO GO:00148 1907|190 EDN2|ED 1 -1.31491 M1 1 0 Biological 19 artery smooth muscle contraction -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 24 8 N3 Processes ACTN2|A DORA2A| CDH9|CD 88|135|10 H10|CHR 07|1008|1 M3|CHRN 131|1134| A1|COMT 1312|204 |EPHB2|G 8|2555|25 ABRA2|G 56|2557|2 ABRA3|G GO 565|2890| ABRA4|G GO:00452 Cellular 1 -4.40396 M1 1 0 20 postsynaptic membrane -4.40396 2.444355 4.732656 24156 283 873 25 2.863688 0.564477 2902|291 ABRG1|G -2.4343 0 58 0 0 -4.67369 3.739203 11 Compone 3|3690|38 RIA1|GRI nts 38|4916|7 N1|GRM3 074|1036 |ITGB3|KP 9|11141|2 NA2|NTR 2871|232 K3|TIAM1 37|57537| |CACNG2| 347730 IL1RAPL1| NLGN1|A RC|SORC S2|LRRTM GO GO:00196 catechol-containing compound catabolic 1312|260 COMT|M 1 -1.31491 M1 1 0 Biological 19 -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 14 process 02 OXD1 Processes GO GO:00325 4089|441 SMAD4|N 1 -1.31491 M1 1 0 Biological 19 somite rostral/caudal axis specification -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 25 478 RARP Processes GO GO:00333 4998|639 ORC1|CLS 1 -1.31491 M1 1 0 Biological 19 mitotic DNA replication checkpoint -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 14 67 PN Processes BRCA1|BR 672|675|2 CA2|FAN 187|2188| CB|FANC Canonical 3280|436 1 -4.39797 M1 M1 1 0 11 PID FANCONI PATHWAY -4.39797 5.29853 5.711767 24156 47 873 9 1.030928 0.341867 F|HES1|M -2.4343 0 44 0 0 -5.52611 9.223368 Pathways 1|55215|8 RE11|FAN 0010|914 CI|RMI1|F 42 AAP24 BRCA2|C 675|1289| OL5A1|H 3070|328 ELLS|HES Canonical 0|3861|43 1 -4.39797 M236 M1 1 0 11 PID DELTA NP63 PATHWAY -4.39797 5.29853 5.711767 24156 47 873 9 1.030928 0.341867 1|KRT14| -2.4343 0 67 1 1 -4.39797 5.29853 Pathways 61|7153|9 MRE11|T 133|1041 OP2A|CC 3 NB2|YAP1 GO GO:00358 glial cell-derived neurotrophic factor 23213|38 SULF1|GF 1 -1.31491 M1 1 0 Biological 19 -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 60 receptor signaling pathway 9400 RAL Processes GO GO:00358 1393|108 CRHBP|P 1 -1.31491 M1 1 0 Biological 19 cellular response to potassium ion -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 65 91 PARGC1A Processes GO GO:00359 4155|106 MBP|POS 1 -1.31491 M1 1 0 Biological 19 chemokine (C-C motif) ligand 2 secretion -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 26 31 TN Processes ALK|EPHB 238|2047| 1|EPHB2| 2048|232 FLT4|MET 4|4233|49 |NTRK3|P 16|5156|6 GO DGFRA|SL GO:00047 503|7075| 1 -4.35611 M1 1 0 Molecular 21 protein tyrosine kinase activity -4.35611 3.185048 5.00265 24156 139 873 16 1.832761 0.453972 A|TIE1|TT -2.39823 0 69 1 1 -4.35611 3.891108 13 7272|746 Functions K|WEE1|R 5|8767|98 IPK2|MEL 33|55359| K|STYK1|P 91461|28 KDCC|EP 4656 HA10 GO GO:00424 1312|260 COMT|M 1 -1.31491 M1 1 0 Biological 19 catecholamine catabolic process -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 24 02 OXD1 Processes 1062|383 CENPE|KI 2|9493|95 F11|KIF23 85|11004| |KIF20B|KI R-HSA- Reactome 1 -4.34199 M1 1 0 6 Kinesins -4.34199 4.689848 5.494702 24156 59 873 10 1.145475 0.360151 24137|26 F2C|KIF4A -2.38795 0 46 0 0 -5.44351 7.281606 983189 Gene Sets 153|7986 |KIF26A|T 1|81027|8 UBAL3|TU 1930 BB1|KIF18 GO GO:00459 positive regulation of transcription by RNA 23379|79 1 -1.31491 M1 1 0 Biological 19 -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 ICE1|ICE2 -0.23909 0 0 45 polymerase III 664 Processes ACTN2|C DH10|CH 88|1008|1 RM3|CHR 131|1134| NA1|GAB 2556|255 RA3|GAB GO 7|2890|29 RA4|GRIA GO:00996 Cellular 02|3838|7 1 -4.33181 M1 1 0 20 postsynaptic specialization membrane -4.33181 3.320412 5.03646 24156 125 873 15 1.718213 0.439813 1|GRIN1| -2.38094 0 58 0 0 -4.67369 3.739203 34 Compone 074|1036 KPNA2|TI nts 9|22871|2 AM1|CAC 3237|575 NG2|NLG 37|34773 N1|ARC|S 0 ORCS2|LR RTM1 BARD1|B CORUM:2 BRCA1-BARD1-BRCA2-DNA damage 580|672|6 1 -4.32747 M1 1 0 CORUM 33 -4.32747 27.6701 8.945219 24156 3 873 3 0.343643 0.198061 RCA1|BR -2.38094 0 70 1 1 -4.32747 27.6701 818 complex III 75 CA2 GO LTBP1|LT GO:00504 4052|405 1 -4.32747 M1 1 0 Molecular 21 microfibril binding -4.32747 27.6701 8.945219 24156 3 873 3 0.343643 0.198061 BP2|ADA -2.38094 0 71 1 1 -4.32747 27.6701 36 3|9719 Functions MTSL2 GO GO:00512 9493|241 KIF23|KIF 1 -1.31491 M1 1 0 Biological 19 spindle elongation -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 31 37 4A Processes GO GO:00514 microtubule nucleation by microtubule 55125|55 CEP192|C 1 -1.31491 M1 1 0 Biological 19 -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 18 organizing center 835 ENPJ Processes GO GO:00519 7056|705 THBD|TH 1 -1.31491 M1 1 0 Biological 19 negative regulation of fibrinolysis -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 18 7 BS1 Processes CDH5|CD 1003|100 GO H7|CDH9| 5|1007|10 GO:00163 Cellular CDH10|C 1 -4.3201 M1 1 0 20 catenin complex -4.3201 6.917526 6.06666 24156 28 873 7 0.801833 0.301847 08|1009|6 -2.37636 0 32 0 0 -6.28754 6.917526 42 Compone DH11|CD 4072|222 nts H23|CDH 256 R3 COL5A1| 1289|149 CCN2|FLT 0|2324|36 4|ITGB3|I 90|3691|4 TGB4|LTB 052|4053| P1|LTBP2| GO 4916|515 GO:00198 NTRK3|P 1 -4.28019 M1 1 0 Molecular 21 growth factor binding -4.28019 3.13987 4.934541 24156 141 873 16 1.832761 0.453972 6|7057|91 -2.33784 0 74 1 1 -4.28019 6.01524 38 DGFRA|T Functions 80|11082| HBS1|OS 11141|22 MR|ESM1 918|1171 |IL1RAPL1 66|12485 |CD93|WF 7 IKKN1|WF GO GO:00603 2201|642 FBN2|SFR 1 -1.31491 M1 1 0 Biological 19 bone trabecula formation -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 46 2 P1 Processes 10051|10 SMC4|SM CORUM:1 1 -4.26486 M1 1 0 CORUM 33 Condensin I-PARP-1-XRCC1 complex -4.26486 15.81149 7.589083 24156 7 873 4 0.45819 0.22857 592|2339 C2|NCAP -2.32666 0 36 0 0 -6.06241 22.13608 59 7|64151 H|NCAPG 1789|100 DNMT3B| CORUM:4 1 -4.26486 M1 1 0 CORUM 33 DNMT3B complex -4.26486 15.81149 7.589083 24156 7 873 4 0.45819 0.22857 51|10592| SMC4|SM -2.32666 0 36 0 0 -6.06241 22.13608 9 24137 C2|KIF4A GO GO:00605 655|2321 BMP7|SU 1 -1.31491 M1 1 0 Biological 19 prostatic bud formation -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 13 3 LF1 Processes GO GO:00716 5629|801 PROX1|C 1 -1.31491 M1 1 0 Biological 19 otic vesicle morphogenesis -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 00 84 EP290 Processes GO GO:00971 11141|22 IL1RAPL1| 1 -1.31491 M1 1 0 Biological 19 presynaptic membrane assembly -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 05 871 NLGN1 Processes GO GO:19043 regulation of dopaminergic neuron 6422|707 SFRP1|TIA 1 -1.31491 M1 1 0 Biological 19 -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 38 differentiation 4 M1 Processes GO GO:00061 2618|547 GART|PP 1 -1.31281 M1 1 0 Biological 19 purine nucleobase metabolic process -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 -0.23909 0 0 44 1|10606 AT|PAICS Processes GO GO:00063 regulation of transcription by RNA 672|2337 BRCA1|IC 1 -1.31281 M1 1 0 Biological 19 -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 -0.23909 0 0 59 polymerase III 9|79664 E1|ICE2 Processes GO CDK1|MR GO:00070 983|4361| 1 -1.31281 M1 1 0 Biological 19 mitotic G2 DNA damage checkpoint -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 E11|CLSP -0.23909 0 0 95 63967 Processes N GO GO:00091 pyrimidine nucleoside triphosphate 1841|185 DTYMK|D 1 -1.31281 M1 1 0 Biological 19 -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 -0.23909 0 0 47 metabolic process 4|50808 UT|AK3 Processes GO BHMT|D GO:00093 635|2995 1 -1.31281 M1 1 0 Biological 19 amine catabolic process -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 MGDH|C -0.23909 0 0 10 8|55349 Processes HDH ACTC1|A CTN1|AD ORA2A|C 70|87|135 DK6|GAB |1021|255 RA2|GAB 5|2556|25 RA3|GAB 57|2565|2 RA4|GAB 890|3690| RG1|GRIA 3691|542 1|ITGB3|I 0|5783|57 TGB4|PO 95|6642|7 DXL|PTP GO 074|7456| N13|PTPR GO:00312 Cellular 7852|854 1 -4.21719 M1 1 0 20 cell leading edge -4.21719 2.118285 4.465909 24156 418 873 32 3.665521 0.635992 J|SNX1|TI -2.29251 0 76 1 1 -4.21719 2.344924 52 Compone 3|9051|10 AM1|WIP nts 324|1078 F1|CXCR4 8|26084|2 |LMO4|PS 9780|549 TPIP1|KL 97|55785| HL41|IQG 57608|81 AP2|ARH 930|8468 GEF26|PA 7|117178| RVB|TESC 152273|1 |FGD6|JC 00506658 AD|KIF18 A|PPP1R9 B|SSX2IP| GO ADORA2 GO:00358 135|186|1 1 -1.31281 M1 1 0 Biological 19 renal sodium excretion -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 A|AGTR2| -0.23909 0 0 12 312 Processes COMT GO ASPA|TNF GO:00487 positive regulation of oligodendrocyte 443|7133| 1 -1.31281 M1 1 0 Biological 19 -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 RSF1B|CX -0.23909 0 0 14 differentiation 7852 Processes CR4 GO TIMP3|TI GO:00510 regulation of membrane protein 7078|707 1 -1.31281 M1 1 0 Biological 19 -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 MP4|TNF -0.23909 0 0 43 ectodomain proteolysis 9|7133 Processes RSF1B GO CYP24A1| GO:00713 1591|517 1 -1.31281 M1 1 0 Biological 19 cellular response to vitamin D -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 PENK|SFR -0.23909 0 0 05 9|6422 Processes P1 GO CD34|PEC GO:00720 947|5175| 1 -1.31281 M1 1 0 Biological 19 glomerular epithelium development -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 AM1|POD -0.23909 0 0 10 5420 Processes XL GO GO:00722 186|3976| AGTR2|LI 1 -1.31281 M1 1 0 Biological 19 regulation of metanephros development -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 -0.23909 0 0 15 10413 F|YAP1 Processes GO 9508|576 ADAMTS GO:19007 regulation of vascular endothelial growth 1 -1.31281 M1 1 0 Biological 19 -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 08|14737 3|JCAD|C -0.23909 0 0 46 factor signaling pathway Processes 2 CBE1 1545|326 CYP1B1|H GO 3|3280|39 PX|HES1|L GO:00464 1 -1.30995 M1 1 0 Biological 19 positive regulation of JAK-STAT cascade -1.30995 2.105334 2.056812 24156 92 873 7 0.801833 0.301847 76|5175|7 IF|PECAM -0.23679 0 0 27 Processes 132|5583 1|TNFRSF 5 1A|CENPJ CMKLR1|L 1240|395 GALS3|PE GO 8|5175|63 GO:00716 CAM1|CX 1 -1.30995 M1 1 0 Biological 19 mononuclear cell migration -1.30995 2.105334 2.056812 24156 92 873 7 0.801833 0.301847 87|7057|1 -0.23679 0 0 74 CL12|THB Processes 96527|72 S1|ANO6| 9230 CCR2 EPHB1|EP 2047|204 HB2|ITPK GO 8|3706|70 GO:01060 A|TIAM1| 1 -1.30995 M1 1 0 Biological 19 neuron projection organization -1.30995 2.105334 2.056812 24156 92 873 7 0.801833 0.301847 74|22871| -0.23679 0 0 27 NLGN1|A Processes 23237|26 RC|SIPA1 037 L1 COL4A5| GO 1287|128 COL4A6| GO:00986 Cellular 8|1289|12 COL5A1| 1 -4.12744 M1 1 0 20 complex of collagen trimers -4.12744 7.905744 6.130383 24156 21 873 6 0.687285 0.279617 -2.21846 0 5 0 0 -15.2617 12.29782 44 Compone 94|1295|4 COL7A1| nts 060 COL8A1|L UM ALDH1A3 |ALOX5|A SPA|BHM 220|240|4 T|BRCA1| 43|635|67 CDO1|VC 2|1036|14 AN|EDN2| 62|1907|2 ESRRB|GA 103|2618| RT|PLA2G 5321|535 GO 4A|PLP1|P GO:00463 4|5563|56 1 -1.30856 M1 1 0 Biological 19 carboxylic acid biosynthetic process -1.30856 1.437408 1.838144 24156 462 873 24 2.749141 0.553399 RKAA2|PR -0.23578 0 0 94 29|5742|7 Processes OX1|PTG 358|8854| S1|UGDH| 9104|108 ALDH1A2 91|23600| |RGN|PPA 51141|55 RGC1A|A 706|8541 MACR|IN 4|157506 SIG2|NDC 1|SLC45A 3|RDH10 1289|233 COL5A1|F 5|3673|39 N1|ITGA2 R-HSA- Reactome 1 -4.11211 M1 1 0 6 MET activates PTK2 signaling -4.11211 6.456357 5.790445 24156 30 873 7 0.801833 0.301847 09|3914|4 |LAMA3|L -2.20442 0 77 1 1 -4.11211 18.44674 8874081 Gene Sets 233|2842 AMB3|ME 17 T|LAMA1 BMP7|CD 655|1021| K6|COL8 1295|219 A1|FBLN2 9|2335|32 |FN1|HES 80|3673|3 1|ITGA2|L 976|5420| IF|PODXL| 5795|638 PTPRJ|CX GO 7|6422|87 CL12|SFR GO:00457 1 -1.3069 M1 1 0 Biological 19 positive regulation of cell adhesion -1.3069 1.463323 1.845785 24156 416 873 22 2.520046 0.530463 67|8772|1 P1|RIPK2| -0.2343 0 0 85 Processes 0125|259 FADD|RA 75|79679| SGRP1|EG 133584|1 FL6|VTCN 36227|15 1|EGFLA 1887|375 M|COL26 567|7292 A1|CCDC 30 80|VWC2| CCR2 BRCA1|D 672|1789| NMT3B|LI 3976|408 F|SMAD4| GO GO:00310 9|5081|55 PAX7|PRK 1 -1.30483 M1 1 0 Biological 19 regulation of histone modification -1.30483 1.820402 1.964706 24156 152 873 10 1.145475 0.360151 -0.2328 0 0 56 87|8726|1 D1|EED|P Processes 0891|551 PARGC1A 83|93649 |RIF1|MY OCD ACTN1|E 87|2047|2 PHB1|EP 048|3706| HB2|ITPK GO 4916|707 A|NTRK3| GO:00991 1 -1.3012 M1 1 0 Biological 19 postsynapse organization -1.3012 1.759371 1.940959 24156 173 873 11 1.260023 0.37751 4|11141|2 TIAM1|IL1 -0.22936 0 0 73 Processes 2871|232 RAPL1|NL 37|26037| GN1|ARC| 347730 SIPA1L1|L RRTM1 332|655|6 BIRC5|BM 75|699|70 P7|BRCA2 1|1062|10 |BUB1|BU 63|1164|1 B1B|CENP 908|3832| E|CENPF| 3976|428 CKS2|ED 8|4361|46 N3|KIF11| 03|4751|6 LIF|MKI67 790|7153| |MRE11| 7272|913 MYBL1|N 4|9232|93 EK2|AURK 19|9493|9 A|TOP2A| 585|9587| TTK|CCN GO 9787|992 E2|PTTG1 GO:00002 1 -19.3541 M1 1 0 Biological 19 nuclear division -19.3541 3.99088 11.91507 24156 416 873 60 6.872852 0.856248 8|10051|1 |TRIP13|KI -15.5178 0 3 1 1 -19.3541 4.553308 80 Processes 0403|104 F23|KIF20 60|10592| B|MAD2L 11004|22 1BP|DLG 974|2339 AP5|KIF14 7|24137|2 |SMC4|N 7085|289 DC80|TA 84|51203| CC3|SMC 54443|54 2|KIF2C|T 820|5502 PX2|NCA 3|55125|5 PH|KIF4A| 5165|557 MTBP|RG 06|56155| CC|NUSA 64151|79 P1|ANLN| 003|7907 NDE1|PHI 655|947|1 BMP7|CD 287|1288| 34|COL4A 1289|129 5|COL4A6 4|1295|12 |COL5A1| 99|1306|1 COL7A1| 462|1490| COL8A1| 1545|180 COL9A3| 5|2199|22 COL15A1| 00|2201|2 VCAN|CC 247|2335| N2|CYP1B 2620|282 1|DPT|FBL 4|3672|36 N2|FBN1| 73|3690|3 FBN2|FGF GO 691|3909| 2|FN1|GA GO:00430 1 -19.3536 M1 1 0 Biological 19 extracellular structure organization -19.3536 3.934444 11.87474 24156 429 873 61 6.9874 0.862823 3914|393 S2|GPM6 -15.5178 0 1 0 0 -22.6822 5.869416 62 Processes 1|4017|40 B|ITGA1|I 60|4237|4 TGA2|ITG 312|4316| B3|ITGB4| 5156|517 LAMA3|L 5|6692|69 AMB3|LC 39|7057|7 AT|LOXL2 093|7132| |LUM|MF 7133|938 AP2|MMP 8|9508|97 1|MMP7| 19|10266| PDGFRA| 10516|10 PECAM1| 631|2321 SPINT1|T 3|23768|2 CF15|THB 5975|289 S1|TLL2|T 1287|128 COL4A5| 8|1289|12 COL4A6| 94|1295|1 COL5A1| 299|1306| COL7A1| 1462|149 COL8A1| 0|1545|18 COL9A3| 05|2199|2 COL15A1| 200|2201| VCAN|CC 2247|233 N2|CYP1B 5|2620|28 1|DPT|FBL 24|3672|3 N2|FBN1| 673|3690| FBN2|FGF 3691|390 2|FN1|GA GO 9|3914|40 S2|GPM6 GO:00301 1 -18.9181 M1 1 0 Biological 19 extracellular matrix organization -18.9181 4.154225 11.88789 24156 373 873 56 6.414662 0.829247 17|4060|4 B|ITGA1|I -15.3253 0 1 0 0 -22.6822 5.869416 98 Processes 237|4312| TGA2|ITG 4316|515 B3|ITGB4| 6|5175|66 LAMA3|L 92|6939|7 AMB3|LO 057|7093| XL2|LUM| 7132|713 MFAP2|M 3|9508|97 MP1|MM 19|10266| P7|PDGFR 10516|10 A|PECAM 631|2321 1|SPINT1| 3|23768|2 TCF15|TH 5975|289 BS1|TLL2| 84|30001| TNFRSF1 55790|58 A|TNFRSF 332|675|6 BIRC5|BR 99|701|89 CA2|BUB 4|899|901 1|BUB1B| |983|1021 CCND2|C |1062|106 CNF|CCN 3|1164|18 G2|CDK1| 94|2103|2 CDK6|CE 247|2277| NPE|CEN 3070|335 PF|CKS2|E 7|3832|47 CT2|ESRR 51|5228|6 B|FGF2|V 790|7153| EGFD|HEL 7465|831 LS|HTR2B GO 7|9133|91 |KIF11|NE GO:00513 1 -18.7185 M1 1 0 Biological 19 cell division -18.7185 3.316778 11.21286 24156 609 873 73 8.36197 0.936882 34|9232|9 K2|PGF|A -15.2131 0 3 0 0 -19.3541 4.553308 01 Processes 493|9585| URKA|TO 9928|993 P2A|WEE 7|10051|1 1|CDC7|C 0403|104 CNB2|CC 60|10592| NE2|PTTG 10733|11 1|KIF23|KI 004|1110 F20B|KIF1 4|22974|2 4|DCLRE1 3397|234 A|SMC4| 21|24137| NDC80|T 26586|51 ACC3|SM 203|5444 C2|PLK4|K 3|54820|5 IF2C|KAT 4821|548 NA1|TPX2 672|699|7 BRCA1|B 01|815|83 UB1|BUB1 5|894|899 B|CAMK2 |901|983| A|CASP2| 1021|103 CCND2|C 0|1062|10 CNF|CCN 63|1164|2 G2|CDK1| 103|2273| CDK6|CD 3161|362 KN2B|CE 4|4175|43 NPE|CEN 61|4751|4 PF|CKS2|E 998|4999| SRRB|FHL 5116|547 1|HMMR|I GO 1|5558|62 NHBA|M GO:00447 1 -18.6968 M1 1 0 Biological 19 mitotic cell cycle phase transition -18.6968 3.348315 11.23076 24156 595 873 72 8.247423 0.931025 41|6790|7 CM6|MRE -15.2131 0 4 1 1 -18.6968 4.032327 72 Processes 029|7272| 11|NEK2| 7465|831 ORC1|OR 7|8318|86 C2|PCNT| 55|9133|9 PPAT|PRI 134|9319| M2|RRM2 9587|966 |AURKA|T 2|9787|98 FDP2|TTK 14|9833|9 |WEE1|CD 928|1040 C7|CDC4 3|10460|1 5|DYNLL1 0733|229 |CCNB2|C 74|27085| CNE2|TRI 27133|28 P13|MAD 984|2976 2L1BP|CE 332|655|6 BIRC5|BM 75|699|70 P7|BRCA2 1|1062|10 |BUB1|BU 63|1164|1 B1B|CENP 908|3832| E|CENPF| 3976|428 CKS2|ED 8|4361|46 N3|KIF11| 03|4751|6 LIF|MKI67 790|7153| |MRE11| 7272|913 MYBL1|N 4|9232|93 EK2|AURK 19|9493|9 A|TOP2A| 585|9587| TTK|CCN GO 9787|992 E2|PTTG1 GO:00482 1 -17.7335 M1 1 0 Biological 19 organelle fission -17.7335 3.653412 11.15058 24156 462 873 61 6.9874 0.862823 8|10051|1 |TRIP13|KI -14.2956 0 3 0 0 -19.3541 4.553308 85 Processes 0403|104 F23|KIF20 60|10592| B|MAD2L 10891|11 1BP|DLG 004|2297 AP5|KIF14 4|23397|2 |SMC4|N 4137|270 DC80|TA 85|28984| CC3|SMC 51203|54 2|PPARG 443|5482 C1A|KIF2 0|55023|5 C|TPX2|N 5125|551 CAPH|KIF 65|55706| 4A|MTBP| 56155|64 RGCC|NU 151|7900 SAP1|ANL 672|699|7 BRCA1|B 01|815|83 UB1|BUB1 5|894|899 B|CAMK2 |901|983| A|CASP2| 1021|103 CCND2|C 0|1062|10 CNF|CCN 63|1164|2 G2|CDK1| 103|2273| CDK6|CD 3161|362 KN2B|CE 4|4175|43 NPE|CEN 61|4751|4 PF|CKS2|E 998|4999| SRRB|FHL 5116|547 1|HMMR|I GO 1|5558|62 NHBA|M GO:00447 1 -17.5028 M1 1 0 Biological 19 cell cycle phase transition -17.5028 3.156121 10.70465 24156 640 873 73 8.36197 0.936882 41|6790|7 CM6|MRE -14.1441 0 4 0 0 -18.6968 4.032327 70 Processes 029|7272| 11|NEK2| 7465|831 ORC1|OR 7|8318|86 C2|PCNT| 55|9133|9 PPAT|PRI 134|9319| M2|RRM2 9587|966 |AURKA|T 2|9787|98 FDP2|TTK 14|9833|9 |WEE1|CD 928|1040 C7|CDC4 3|10460|1 5|DYNLL1 0733|229 |CCNB2|C 74|27085| CNE2|TRI 27133|28 P13|MAD 984|2976 2L1BP|CE 655|672|6 BMP7|BR 75|699|70 CA1|BRC 1|835|894 A2|BUB1| |899|983| BUB1B|C 1021|103 ASP2|CC 0|1062|10 ND2|CCN 63|1490|1 F|CDK1|C 894|1908| DK6|CDK 2273|316 N2B|CEN 1|3832|39 PE|CENPF 76|4288|4 |CCN2|EC 361|4751| T2|EDN3| 4998|511 FHL1|HM GO 6|5931|62 MR|KIF11| GO:00105 1 -16.4495 M1 1 0 Biological 19 regulation of cell cycle process -16.4495 2.819218 10.09982 24156 795 873 81 9.278351 0.981937 41|6422|6 LIF|MKI67 -13.1577 0 4 0 0 -18.6968 4.032327 64 Processes 491|6790| |MRE11|N 7029|727 EK2|ORC1 2|7465|83 |PCNT|RB 17|8318|8 BP7|RRM 655|8726| 2|SFRP1|S 9232|931 TIL|AURK 9|9493|95 A|TFDP2| 85|9587|9 TTK|WEE1 662|9787| |CDC7|CD 9814|992 C45|DYN 8|10403|1 LL1|EED|P 0460|107 TTG1|TRI 33|22974| P13|KIF23 25886|27 |KIF20B|M GO BUB1|BU 699|701|1 GO:00009 Cellular B1B|CENP 1 -4.03183 M1 1 0 20 condensed chromosome outer kinetochore -4.03183 9.88218 6.437068 24156 14 873 5 0.572738 0.255402 063|1040 -2.14048 0 25 0 0 -7.23866 13.83505 40 Compone F|NDC80| 3|221150 nts SKA3 332|655|6 BIRC5|BM 99|701|10 P7|BUB1| 62|1063|1 BUB1B|CE 908|3832| NPE|CEN 4288|475 PF|EDN3| 1|6790|72 KIF11|MKI 72|9232|9 67|NEK2| 319|9493| AURKA|T 9585|958 TK|PTTG1 7|9787|99 |TRIP13|KI 28|10051| F23|KIF20 10403|10 B|MAD2L 460|1059 1BP|DLG GO 2|11004|2 AP5|KIF14 GO:01400 1 -16.2677 M1 1 0 Biological 19 mitotic nuclear division -16.2677 4.492563 11.19586 24156 271 873 44 5.040092 0.740427 2974|233 |SMC4|N -13.0059 0 3 0 0 -19.3541 4.553308 14 Processes 97|24137| DC80|TA 27085|28 CC3|SMC 984|5120 2|KIF2C|T 3|54443|5 PX2|NCA 4820|550 PH|KIF4A| 23|55125| MTBP|RG 55165|56 CC|NUSA 155|6415 P1|ANLN| 1|79003|7 NDE1|PHI 9075|798 P|CEP192| 66|81930| CEP55|TE 83540|84 X14|NCA 687|1267 PG|MIS12 31 |DSCC1|B COL5A1|F 1289|233 N1|ITGA2 5|3673|39 R-HSA- Reactome |LAMA3|L 1 -4.03008 M1 1 0 6 MET promotes cell motility -4.03008 5.399045 5.458808 24156 41 873 8 0.91638 0.322501 09|3914|4 -2.13996 0 77 0 0 -4.11211 18.44674 8875878 Gene Sets AMB3|ME 233|6475 T|TNS3|L 9|284217 AMA1 655|672|6 BMP7|BR 75|699|70 CA1|BRC 1|835|894 A2|BUB1| |983|1021 BUB1B|C |1030|106 ASP2|CC 2|1063|11 ND2|CDK 64|1908|2 1|CDK6|C 273|2619| DKN2B|C 3161|328 ENPE|CE 0|3832|42 NPF|CKS2 14|4288|4 |EDN3|FH 361|4751| L1|GAS1| 4998|511 HMMR|H GO 6|6790|70 ES1|KIF11 GO:00073 1 -14.7996 M1 1 0 Biological 19 regulation of mitotic cell cycle -14.7996 2.813256 9.551073 24156 718 873 73 8.36197 0.936882 29|7153|7 |MAP3K1| -11.6169 0 4 0 0 -18.6968 4.032327 46 Processes 272|7465| MKI67|M 8317|831 RE11|NEK 8|8655|92 2|ORC1|P 32|9319|9 CNT|AUR 585|9587| KA|TFDP2 9662|978 |TOP2A|T 7|9814|99 TK|WEE1| 28|10403| CDC7|CD 10460|10 C45|DYN 733|2297 LL1|PTTG 4|27085|2 1|TRIP13| 7133|289 KIF20B|M 84|29766| AD2L1BP| 51203|51 CEP135|D 332|672|6 BIRC5|BR 99|701|10 CA1|BUB 62|1063|1 1|BUB1B| 894|4288| CENPE|CE 4361|475 NPF|ECT2 1|7153|72 |MKI67|M 72|9134|9 RE11|NEK 232|9319| 2|TOP2A| 9493|978 TTK|CCN 7|9928|10 E2|PTTG1 051|1040 |TRIP13|KI 3|10460|1 F23|DLGA 0592|110 P5|KIF14| GO 04|23397| SMC4|ND GO:00070 1 -13.5819 M1 1 0 Biological 19 chromosome segregation -13.5819 3.739203 9.746289 24156 333 873 45 5.154639 0.748342 24137|51 C80|TACC -10.445 0 3 0 0 -19.3541 4.553308 59 Processes 203|5482 3|SMC2|K 0|55165|5 IF2C|NCA 5355|557 PH|KIF4A| 06|55839| NUSAP1| 56155|57 NDE1|CE 082|5740 P55|HJUR 5|64151|7 P|NDC1|C 9003|790 ENPN|TE 75|80010| X14|KNL1 81930|83 |SPC25|N 540|8469 CAPG|MI 0|146956| S12|DSCC 150280|1 1|RMI1|KI 57313|22 F18A|NUF 672|699|7 BRCA1|B 01|835|89 UB1|BUB1 4|983|102 B|CASP2| 1|1030|10 CCND2|C 62|1063|2 DK1|CDK 273|3161| 6|CDKN2 4361|475 B|CENPE| 1|4998|51 CENPF|FH 16|6790|7 L1|HMMR 029|7272| |MRE11|N 7465|831 EK2|ORC1 7|8318|86 |PCNT|AU 55|9319|9 RKA|TFDP GO 587|9662| 2|TTK|WE GO:19019 regulation of mitotic cell cycle phase 1 -13.4231 M1 1 0 Biological 19 -13.4231 3.266181 9.385788 24156 449 873 53 6.071019 0.808209 9787|981 E1|CDC7| -10.3075 0 4 0 0 -18.6968 4.032327 90 transition Processes 4|9928|10 CDC45|D 403|1073 YNLL1|TRI 3|22974|2 P13|MAD 7085|271 2L1BP|CE 33|28984| P135|DLG 29766|51 AP5|SFI1| 512|5151 KIF14|ND 4|54443|5 C80|PLK4| 4820|550 TPX2|MT 31|55125| BP|KCNH 55835|56 5|RGCC|T 155|5716 MOD3|GT 5|63967|7 SE1|DTL| 9441|801 ANLN|ND FGF2|ITG 2247|369 B3|LTBP1| 0|4052|70 THBS1|TN 57|7132|7 FRSF1A|T 133|7852| NFRSF1B| GO GO:00199 9180|111 CXCR4|O 1 -4.01991 M1 1 0 Molecular 21 cytokine binding -4.01991 3.120688 4.74876 24156 133 873 15 1.718213 0.439813 -2.13468 0 74 0 0 -4.28019 6.01524 55 41|22918| SMR|IL1R Functions 51554|53 APL1|CD9 832|1171 3|ACKR4|I 66|12485 L20RA|W 7|729230 FIKKN1|W FIKKN2|C CENPF|KI 1063|383 F11|NEK2 2|4751|67 |AURKA|K 90|9585|9 IF20B|DL 787|1046 GAP5|TA GO 0|10733|1 CC3|PLK4 GO:00009 Cellular 1104|229 1 -4.01173 M1 1 0 20 spindle pole -4.01173 2.868242 4.648503 24156 164 873 17 1.947308 0.467671 |KATNA1| -2.12772 0 80 1 1 -4.01173 9.223368 22 Compone 74|25886| TPX2|PO nts 26586|54 C1A|CKA 820|5511 P2|NDE1| 2|55171|1 WDR60|T 21441|25 BCCD1|N 9266 EDD1|AS 672|699|7 BRCA1|B 01|835|89 UB1|BUB1 4|983|102 B|CASP2| 1|1030|10 CCND2|C 62|1063|2 DK1|CDK 273|3161| 6|CDKN2 4361|475 B|CENPE| 1|4998|51 CENPF|FH 16|6790|7 L1|HMMR 029|7272| |MRE11|N 7465|831 EK2|ORC1 7|8318|86 |PCNT|AU 55|9319|9 RKA|TFDP GO 587|9662| 2|TTK|WE GO:19019 1 -12.5506 M1 1 0 Biological 19 regulation of cell cycle phase transition -12.5506 3.068143 8.927837 24156 487 873 54 6.185567 0.8153 9787|981 E1|CDC7| -9.45516 0 4 0 0 -18.6968 4.032327 87 Processes 4|9928|10 CDC45|D 403|1073 YNLL1|TRI 3|22974|2 P13|MAD 7085|271 2L1BP|CE 33|28984| P135|DLG 29766|51 AP5|SFI1| 512|5151 KIF14|ND 4|54443|5 C80|PLK4| 4820|550 TPX2|MT 31|55125| BP|KCNH 55835|56 5|RGCC|T 155|5716 MOD3|GT 5|63967|7 SE1|DTL| 9441|801 ANLN|ND BRCA1|C 672|983|1 DK1|CDK 030|1063| N2B|CEN 2103|227 PF|ESRRB| 3|3161|43 FHL1|HM 61|4751|4 MR|MRE1 998|5116| 1|NEK2|O 6790|746 RC1|PCN 5|8317|86 T|AURKA| 55|9133|9 WEE1|CD 662|9814| C7|DYNLL 9833|992 1|CCNB2| GO 8|10733|2 CEP135|S GO:00448 1 -12.0649 M1 1 0 Biological 19 cell cycle G2/M phase transition -12.0649 3.879941 9.23202 24156 271 873 38 4.352806 0.690579 2974|271 FI1|MELK| -9.02491 0 4 0 0 -18.6968 4.032327 39 Processes 33|51512| KIF14|PLK 51514|54 4|TPX2|K 820|5503 CNH5|GT 1|55125|5 SE1|DTL| 5835|639 NDE1|US 67|79441| P47|CEP1 79866|80 92|CENPJ| 169|8018 CLSPN|H 4|84930|8 AUS3|BO 5417|121 RA|CTC1| 441|1521 CEP290| 10 MASTL|C CNB3|NE 186|331|6 AGTR2|XI 55|753|10 AP|BMP7| 03|1030|1 LDLRAD4| 385|1490| CDH5|CD 1841|220 KN2B|CRE 0|2201|22 B1|CCN2| 47|2277|2 DTYMK|F 324|2619| BN1|FBN 3280|369 2|FGF2|VE 0|4052|40 GFD|FLT4| 53|4060|4 GAS1|HES 089|4090| 1|ITGB3|L 4208|491 TBP1|LTB GO 6|5156|51 P2|LUM|S GO:00708 1 -11.8343 M1 1 0 Biological 19 response to growth factor -11.8343 2.556477 8.303847 24156 736 873 68 7.789233 0.90705 79|5228|5 MAD4|S -8.82778 0 6 1 1 -11.8343 3.804639 48 Processes 587|6422| MAD5|M 6425|645 EF2C|NTR 6|6498|66 K3|PDGFR 92|6935|7 A|PENK|P 054|7057| GF|PRKD1 7133|848 |SFRP1|SF 3|9508|97 RP5|SH3G 19|10266| L2|SKIL|SP 10454|10 INT1|ZEB 468|1063 1|TH|THB 1|10891|2 S1|TNFRS 3213|237 F1B|CILP| 68|25878| ADAMTS 27063|54 3|ADAMT ACTN1|A 87|88|215 CTN2|F8| 7|2277|23 VEGFD|F GO 35|3690|5 N1|ITGB3| GO:00310 Cellular 1 -3.97669 M1 1 0 20 platelet alpha granule -3.97669 3.648805 4.90195 24156 91 873 12 1.37457 0.394068 175|5270| PECAM1| -2.09968 0 81 1 1 -3.97669 6.510612 91 Compone 7057|705 SERPINE2 nts 8|10184|9 |THBS1|T 4121 HBS2|LHF PL2|SYTL 186|331|6 AGTR2|XI 55|753|10 AP|BMP7| 03|1030|1 LDLRAD4| 385|1490| CDH5|CD 1841|220 KN2B|CRE 0|2201|22 B1|CCN2| 47|2277|2 DTYMK|F 324|2619| BN1|FBN 3280|369 2|FGF2|VE 0|4052|40 GFD|FLT4| 53|4089|4 GAS1|HES 090|4208| 1|ITGB3|L 4916|515 TBP1|LTB GO 6|5179|52 P2|SMAD GO:00713 1 -11.728 M1 1 0 Biological 19 cellular response to growth factor stimulus -11.728 2.586724 8.285588 24156 706 873 66 7.560137 0.89472 28|5587|6 4|SMAD5| -8.75246 0 6 0 0 -11.8343 3.804639 63 Processes 422|6425| MEF2C|N 6456|649 TRK3|PD 8|6692|69 GFRA|PE 35|7054|7 NK|PGF|P 057|7133| RKD1|SFR 8483|950 P1|SFRP5| 8|9719|10 SH3GL2|S 266|1045 KIL|SPINT 4|10468|1 1|ZEB1|T 0631|108 H|THBS1| 91|23213| TNFRSF1 23768|27 B|CILP|AD 063|5456 AMTS3|A 7|55816|5 DAMTSL2 GO 7135|713 TNNI1|TN GO:00058 Cellular 1 -3.97647 M1 1 0 20 troponin complex -3.97647 13.83505 7.030613 24156 8 873 4 0.45819 0.22857 6|7139|71 NI2|TNNT -2.09968 0 61 0 0 -4.53228 18.44674 61 Compone 40 2|TNNT3 nts ACTN1|A CTN2|CN 87|88|126 N3|FHL3| 6|2275|71 TNNI1|TN 35|7136|7 NI2|TNNT 139|7140| 2|TNNT3| 7456|785 WIPF1|CX 2|8727|96 CR4|CTN 45|10529| NAL1|MI 10788|11 CAL2|NEB 346|2299 L|IQGAP2 GO 8|26064|2 |SYNPO|LI GO:00037 1 -3.96838 M1 1 0 Molecular 21 actin binding -3.96838 2.054393 4.2769 24156 431 873 32 3.665521 0.635992 7295|297 MCH1|RA -2.09278 0 48 0 0 -5.29557 3.217454 79 Functions 66|29780| I14|PDLI 50853|53 M3|TMO 904|5422 D3|PARV 1|54443|5 B|VILL|MY 7619|603 O3A|SNT 12|81930| G2|ANLN| 84687|84 SHROOM 940|9162 3|AFAP1| 4|91977|1 KIF18A|P 35138 PP1R9B|C ORO6|NE XN|MYOZ ACTL6A|A HR|PRDM 86|196|63 1|CREB1|E 9|1385|18 2F2|ERG|E 70|2078|2 SRRB|FOX 103|2307| S1|FLI1|H 2313|301 2AZ1|HES 5|3280|40 1|SMAD4| 89|4090|4 SMAD5| 208|4222| MEF2C|M 4603|461 EOX1|MY 0|4772|53 BL1|MYCL 08|5629|5 |NFATC1| 992|6095| GO PITX2|PR GO:00009 proximal promoter sequence-specific DNA 6258|649 1 -3.95806 M1 1 0 Molecular 21 -3.95806 1.847606 4.170877 24156 629 873 42 4.810997 0.724275 OX1|RFX4 -2.08395 0 82 1 1 -3.95806 2.352519 87 binding 8|6935|69 Functions |RORA|RX 36|6939|7 RG|SKIL|Z 022|8543| EB1|GCFC 8726|924 2|TCF15|T 2|10413|1 FAP2C|L 0732|107 MO4|EED 36|23598| |MSC|YAP 29128|30 1|TCFL5|S 812|6464 IX2|PATZ 1|93649|1 1|UHRF1| 44455|61 SOX8|EBF 9279|642 2|MYOCD 658 |E2F7|ZNF 704|SCX BRCA1|C DK1|CDK 672|983|1 N2B|CEN 030|1063| PF|ESRRB| 2103|227 FHL1|HM 3|3161|43 MR|MRE1 61|4751|4 1|NEK2|O 998|5116| RC1|PCN 6790|746 T|AURKA| 5|8317|86 WEE1|CD 55|9133|9 C7|DYNLL 662|9814| 1|CCNB2| GO 9833|992 GO:00000 CEP135|S 1 -11.7054 M1 1 0 Biological 19 G2/M transition of mitotic cell cycle -11.7054 3.952872 9.124325 24156 252 873 36 4.123711 0.672965 8|10733|2 -8.74459 0 4 0 0 -18.6968 4.032327 86 FI1|MELK| Processes 2974|271 KIF14|PLK 33|51514| 4|TPX2|K 54820|55 CNH5|DT 031|5512 L|NDE1|U 5|55835|6 SP47|CEP 3967|794 192|CENP 41|79866| J|CLSPN| 80169|80 HAUS3|B 184|8493 ORA|CTC 0|85417|1 1|CEP290| 21441 MASTL|C CNB3|NE 220|655|1 ALDH1A3 289|1294| |BMP7|C 1295|138 OL5A1|C 2|2048|22 OL7A1|C 00|2201|2 OL8A1|C 247|2335| RABP2|EP 2535|328 HB2|FBN1 0|3357|36 |FBN2|FG 24|3673|3 F2|FN1|FZ 690|3691| D2|HES1| 3909|391 HTR2B|IN 4|4089|41 HBA|ITGA 55|4208|4 2|ITGB3|I GO 237|5156| TGB4|LA GO:00485 1 -11.4306 M1 1 0 Biological 19 embryonic morphogenesis -11.4306 2.720893 8.265517 24156 600 873 59 6.758305 0.849605 5629|642 MA3|LAM -8.48405 0 7 1 1 -11.4306 6.148912 98 Processes 2|6491|66 B3|SMAD 92|6935|7 4|MBP|M 054|7296| EF2C|MF 7358|854 AP2|PDG 3|8854|90 FRA|PRO 96|9423|9 X1|SFRP1| 585|9645| STIL|SPIN 10413|10 T1|ZEB1|T 736|2321 H|TXNRD 3|30812|5 1|UGDH|L 1098|511 MO4|ALD 41|53904| H1A2|TBX 54567|55 18|NTN1| 112|5761 KIF20B|MI 332|672|6 BIRC5|BR 75|899|98 CA1|BRC 3|1003|10 A2|CCNF| 62|3832|4 CDK1|CD 233|4751| H5|CENP 5116|556 E|KIF11|M 3|6491|67 ET|NEK2| 90|7272|7 PCNT|PR 465|9493| KAA2|STI 9648|966 L|AURKA| 2|9928|10 TTK|WEE1 403|1046 |KIF23|GC 0|10733|1 C2|CEP13 GO 1004|111 5|KIF14|N GO:00002 1 -11.3911 M1 1 0 Biological 19 microtubule cytoskeleton organization -11.3911 2.743361 8.265466 24156 585 873 58 6.643757 0.842891 04|22974| DC80|TA -8.45836 0 8 1 1 -11.3911 5.158833 26 Processes 24137|25 CC3|PLK4 886|2658 |KIF2C|KA 6|51203|5 TNA1|TPX 4820|551 2|KIF4A|P 25|55137| OC1A|CK 55835|56 AP2|NUS 890|5715 AP1|NDE 9|57405|7 1|CEP192| 9441|796 FIGN|CEN 48|79861| PJ|MDM1 79866|81 |TRIM54|S 027|8193 PC25|HA 0|83540|8 US3|MCP 4612|854 H1|TUBAL BUB1|BU 699|701|1 B1B|CENP 062|1063| E|CENPF| 1894|436 ECT2|MR 1|4751|71 E11|NEK2 53|7272|9 |TOP2A|T 134|9232| TK|CCNE 9319|949 2|PTTG1| 3|9787|99 TRIP13|KI 28|10051| F23|DLGA 10403|10 P5|KIF14| 460|1059 SMC4|ND GO GO:00988 2|11004|2 C80|TACC 1 -10.769 M1 1 0 Biological 19 nuclear chromosome segregation -10.769 3.675733 8.577407 24156 271 873 36 4.123711 0.672965 -7.84965 0 3 0 0 -19.3541 4.553308 13 3397|241 3|SMC2|K Processes 37|51203| IF2C|NCA 55165|55 PH|KIF4A| 706|5615 NUSAP1| 5|57082|6 CEP55|N 4151|790 DC1|TEX1 03|79075| 4|KNL1|N 80010|81 CAPG|MI 930|8354 S12|DSCC 0|84690|1 1|RMI1|KI 46956|15 F18A|NUF 0280 2|SPATA2 2|EME1|H BRCA2|B 675|699|7 UB1|BUB1 01|1164|3 B|CKS2|LI 976|4361| F|MRE11| 4603|679 MYBL1|A 0|7153|72 URKA|TO 72|9134|9 P2A|TTK| 232|9319| CCNE2|P 10051|10 TTG1|TRI GO 592|2339 P13|SMC GO:01400 1 -10.3048 M1 1 0 Biological 19 meiotic nuclear division -10.3048 4.377191 8.732085 24156 177 873 28 3.207331 0.596329 7|55706|5 4|SMC2|N -7.43514 0 9 1 1 -10.3048 5.16914 13 Processes 6155|800 CAPH|ND 10|81930| C1|TEX14| 83540|84 RMI1|KIF1 057|8469 8A|NUF2| 0|84930|9 MND1|SP 1646|146 ATA22|M 956|1502 ASTL|TDR 80|25926 D12|EME 6 1|HORMA D2|ASPM BRCA1|C 672|983|1 DK1|CEN 063|2273| PF|FHL1| 3161|436 HMMR|M 1|4751|49 RE11|NEK 98|5116|6 2|ORC1|P 790|8317| CNT|AUR 8655|966 KA|CDC7| 2|9814|99 DYNLL1|C 28|10733| EP135|SFI GO GO:19027 regulation of cell cycle G2/M phase 22974|27 1|KIF14|P 1 -10.221 M1 1 0 Biological 19 -10.221 3.971172 8.493443 24156 216 873 31 3.550974 0.626348 -7.36293 0 4 0 0 -18.6968 4.032327 49 transition 133|5151 LK4|TPX2| Processes 2|51514|5 KCNH5|G 4820|550 TSE1|DTL| 31|55125| NDE1|US 55835|63 P47|CEP1 967|7944 92|CENPJ| 1|80169|8 CLSPN|H 0184|854 AUS3|CT 17|12144 C1|CEP29 1|152110 0|CCNB3| NEDD1|N 70|186|22 ACTC1|A 0|655|128 GTR2|AL 9|1294|22 DH1A3|B 39|2247|2 MP7|COL 535|3280| 5A1|COL7 3624|367 A1|GPC4| 3|3690|36 FGF2|FZD 91|3909|3 2|HES1|IN 976|4089| HBA|ITGA 4208|423 2|ITGB3|I 3|5081|52 TGB4|LA 28|5420|5 MA3|LIF|S 629|6422| MAD4|M GO 6491|669 EF2C|MET GO:00487 1 -10.1376 M1 1 0 Biological 19 tissue morphogenesis -10.1376 2.482171 7.591575 24156 680 873 61 6.9874 0.862823 2|6939|70 |PAX7|PG -7.29673 0 10 1 1 -10.1376 3.952872 29 Processes 74|7135|7 F|PODXL| 139|7296| PROX1|SF 7852|854 RP1|STIL| 3|8854|90 SPINT1|T 96|9423|9 CF15|TIA 585|9645| M1|TNNI 9723|104 1|TNNT2| 13|10468| TXNRD1| 10736|23 CXCR4|L 213|2341 MO4|ALD 4|27063|3 H1A2|TBX 0812|510 18|NTN1| 98|54567| KIF20B|MI 57619|64 CAL2|SE 655|1009| BMP7|CD 1240|129 H11|CMK 4|1462|14 LR1|COL7 90|2200|2 A1|VCAN| 201|2247| CCN2|FB 2313|401 N1|FBN2| 7|4060|40 FGF2|FLI1 90|4208|4 |LOXL2|L 883|5081| UM|SMA 5125|515 D5|MEF2 6|5308|57 C|NPR3|P 44|6422|6 AX7|PCSK 935|6939| 5|PDGFR GO 8111|906 A|PITX2|P GO:00015 1 -10.1305 M1 1 0 Biological 19 skeletal system development -10.1305 2.719935 7.745093 24156 529 873 52 5.956472 0.801036 1|9104|92 THLH|SFR -7.29673 0 11 1 1 -10.1305 3.03234 01 Processes 49|10468| P1|ZEB1|T 10736|23 CF15|GPR 213|2588 68|PAPSS 6|51141|5 1|RGN|D 1715|551 HRS3|FST| 12|55790| SIX2|SULF 56034|56 1|POC1A| 172|7964 INSIG2|R 8|80169|8 AB23|WD 0263|914 R60|CSGA 61|11603 LNACT1|P 9|117166| DGFC|AN 124857|1 KH|MCPH 45864|15 1|CTC1|T COL5A1|F 1289|233 N1|ITGA2 5|3673|39 |LAMA3|L 09|3914|4 R-HSA- Reactome AMB3|ME 1 -3.90769 M1 1 0 6 Signaling by MET -3.90769 3.852799 4.917844 24156 79 873 11 1.260023 0.37751 233|5795| -2.04498 0 77 0 0 -4.11211 18.44674 6806834 Gene Sets T|PTPRJ|S 6456|669 H3GL2|SP 2|64759|2 INT1|TNS 84217 3|LAMA1 BMP7|BU B1|BUB1B 655|699|7 |CENPE|C 01|1062|1 ENPF|ED 063|1908| N3|KIF11| 3832|428 MKI67|NE 8|4751|67 K2|AURK 90|7272|9 A|TTK|PT 232|9319| TG1|TRIP GO 9585|958 GO:00070 13|KIF20B 1 -10.1218 M1 1 0 Biological 19 regulation of mitotic nuclear division -10.1218 4.446981 8.681358 24156 168 873 27 3.092784 0.58593 7|9787|10 -7.29673 0 3 0 0 -19.3541 4.553308 88 |MAD2L1 Processes 403|1046 BP|DLGA 0|27085|2 P5|NDC8 8984|512 0|TACC3| 03|54443| MTBP|RG 55023|56 CC|NUSA 155|7986 P1|ANLN| 6|84687|1 PHIP|TEX 26731 14|BORA| PPP1R9B| BUB1|BU 699|701|1 B1B|CENP 062|1063| E|CENPF| 4751|727 NEK2|TTK 2|9232|93 |PTTG1|T 19|9493|9 RIP13|KIF 787|9928| 23|DLGAP 10051|10 5|KIF14|S GO 403|1046 GO:00000 MC4|NDC 1 -10.0053 M1 1 0 Biological 19 mitotic sister chromatid segregation -10.0053 4.553308 8.676909 24156 158 873 26 2.978236 0.575317 0|10592|1 -7.21089 0 3 0 0 -19.3541 4.553308 70 80|TACC3 Processes 1004|233 |SMC2|KIF 97|24137| 2C|NCAP 51203|55 H|KIF4A| 165|5615 NUSAP1| 5|64151|7 CEP55|TE 9003|790 X14|NCA 75|81930| PG|MIS12 83540 |DSCC1|KI MCM6|O 4175|499 GO RC1|ORC GO:00036 8|4999|83 1 -3.88473 M1 1 0 Molecular 21 DNA replication origin binding -3.88473 7.218288 5.777238 24156 23 873 6 0.687285 0.279617 2|CDC45| -2.02567 0 20 0 0 -7.69554 7.546392 88 18|55388| Functions MCM10| 254394 MCM9 LDLRAD4| 753|4089| SMAD4|A GO GO:00704 27063|28 NKRD1|R 1 -3.88473 M1 1 0 Molecular 21 R-SMAD binding -3.88473 7.218288 5.777238 24156 23 873 6 0.687285 0.279617 -2.02567 0 84 1 1 -3.88473 11.06804 12 984|5693 GCC|PME Functions 7|93649 PA1|MYO CD BUB1|BU 699|701|1 B1B|CENP 062|1063| E|CENPF| 4361|475 MRE11|N 1|7153|72 EK2|TOP2 72|9232|9 A|TTK|PT 319|9493| TG1|TRIP 9787|992 13|KIF23| 8|10051|1 DLGAP5| GO 0403|104 KIF14|SM GO:00008 1 -9.92705 M1 1 0 Biological 19 sister chromatid segregation -9.92705 4.094046 8.421754 24156 196 873 29 3.321879 0.606525 60|10592| C4|NDC8 -7.15192 0 3 0 0 -19.3541 4.553308 19 Processes 11004|23 0|TACC3| 397|2413 SMC2|KIF 7|51203|5 2C|NCAP 5165|561 H|KIF4A| 55|64151| NUSAP1| 79003|79 CEP55|TE 075|8193 X14|NCA 0|83540|1 PG|MIS12 50280 |DSCC1|KI F18A|NUF 70|88|186 ACTC1|A |639|655| CTN2|AG 983|1289| TR2|PRD 1385|220 M1|BMP7 0|2247|25 |CDK1|CO 35|3280|3 L5A1|CRE 357|4052| B1|FBN1| 4089|420 FGF2|FZD 8|4772|48 2|HES1|H 86|4916|5 TR2B|LTB 125|5156| P1|SMAD 5308|560 4|MEF2C| 0|5629|64 NFATC1| GO 45|6491|7 NPY1R|N GO:00075 1 -9.83559 M1 1 0 Biological 19 heart development -9.83559 2.583796 7.535218 24156 589 873 55 6.300115 0.822312 029|7054| TRK3|PCS -7.06979 0 13 1 1 -9.83559 6.28866 07 Processes 7132|713 K5|PDGFR 3|7135|71 A|PITX2| 39|8543|8 MAPK11| 854|9249| PROX1|S 9645|102 GCG|STIL| 66|10413| TFDP2|TH 10454|10 |TNFRSF1 529|1117 A|TNFRSF 4|23414|2 1B|TNNI1 3768|270 |TNNT2|L 63|27295| MO4|ALD 51098|54 H1A2|DH 567|5753 RS3|MICA 8|64091|9 L2|RAMP BRCA1|C 672|983|1 DK1|CEN 063|2273| PF|FHL1| 3161|436 HMMR|M 1|4751|49 RE11|NEK 98|5116|6 2|ORC1|P 790|8317| CNT|AUR 8655|966 KA|CDC7| 2|9814|99 DYNLL1|C GO 28|10733| GO:00103 regulation of G2/M transition of mitotic cell EP135|SFI 1 -9.76547 M1 1 0 Biological 19 -9.76547 4.032327 8.317206 24156 199 873 29 3.321879 0.606525 22974|27 -7.00882 0 4 0 0 -18.6968 4.032327 89 cycle 1|KIF14|P Processes 133|5151 LK4|TPX2| 4|54820|5 KCNH5|D 5031|551 TL|NDE1| 25|55835| USP47|CE 63967|79 P192|CEN 441|8016 PJ|CLSPN| 9|80184|8 HAUS3|C 5417|121 TC1|CEP2 441 90|CCNB 332|672|6 BIRC5|BR 75|899|98 CA1|BRC 3|1003|10 A2|CCNF| 62|3832|4 CDK1|CD 233|4751| H5|CENP 5116|556 E|KIF11|M 3|6491|67 ET|NEK2| 90|7272|7 PCNT|PR 465|8655| KAA2|STI 9493|958 L|AURKA| 5|9648|96 TTK|WEE1 62|9787|9 |DYNLL1| 928|1012 KIF23|KIF GO 5|10403|1 20B|GCC2 GO:00070 1 -9.74461 M1 1 0 Biological 19 microtubule-based process -9.74461 2.329371 7.327359 24156 784 873 66 7.560137 0.89472 0460|107 |CEP135| -6.99691 0 8 0 0 -11.3911 5.158833 17 Processes 33|11004| DLGAP5| 11104|22 KIF14|RAS 974|2413 GRP1|ND 7|25886|2 C80|TACC 6153|265 3|PLK4|KI 86|51098| F2C|KATN 51203|51 A1|TPX2| 512|5482 KIF4A|PO 0|55112|5 C1A|KIF2 5125|551 6A|CKAP2 37|55835| |IFT52|NU 56890|57 SAP1|GTS 159|5740 E1|NDE1| 5|79441|7 WDR60|C 70|87|88| ACTC1|A 1003|128 CTN1|AC 9|1490|15 TN2|CDH 45|1805|3 5|COL5A1 861|4017| |CCN2|CY 4053|406 P1B1|DPT 0|4089|42 |KRT14|L 08|4233|5 OXL2|LTB 156|5629| P2|LUM|S 6387|642 MAD4|M 2|7139|71 EF2C|MET 40|7456|9 |PDGFRA| 508|9645| PROX1|C GO 9928|993 XCL12|SF GO:00974 1 -9.68163 M1 1 0 Biological 19 supramolecular fiber organization -9.68163 2.418161 7.362052 24156 698 873 61 6.9874 0.862823 8|10324|1 RP1|TNN -6.96802 0 14 1 1 -9.68163 3.166231 35 Processes 0516|105 T2|TNNT 29|10788| 3|WIPF1| 11004|11 ADAMTS 104|1134 3|MICAL2 6|22843|2 |KIF14|AR 2974|229 HGAP25| 98|23433| KLHL41|F 26586|27 BLN5|NEB 063|2729 L|IQGAP2 5|28984|2 |KIF2C|KA 9766|508 TNA1|SY 53|54820| NPO|PPM 55125|55 1E|TPX2|L 137|5583 IMCH1|R BMP7|BU 655|699|7 B1|BUB1B 01|1062|1 |CENPE|C 063|1908| ENPF|ED 3832|397 N3|KIF11| 6|4288|47 LIF|MKI67 51|6790|7 |NEK2|AU 272|9232| RKA|TTK| 9319|958 PTTG1|TR GO GO:00517 5|9587|97 IP13|KIF2 1 -9.45877 M1 1 0 Biological 19 regulation of nuclear division -9.45877 4.035223 8.176224 24156 192 873 28 3.207331 0.596329 -6.76124 0 3 0 0 -19.3541 4.553308 83 87|10403| 0B|MAD2 Processes 10460|27 L1BP|DLG 085|2898 AP5|NDC 4|51203|5 80|TACC3 4443|550 |MTBP|RG 23|56155| CC|NUSA 79866|84 P1|ANLN| 687|1267 PHIP|TEX 31 14|BORA| PPP1R9B| BRCA2|B 675|699|7 UB1|BUB1 01|1164|3 B|CKS2|LI 976|4361| F|MRE11| 4603|679 MYBL1|A 0|7153|72 URKA|TO 72|9134|9 P2A|TTK| 232|9319| CCNE2|P 10051|10 TTG1|TRI GO 592|2339 P13|SMC GO:19030 1 -9.40561 M1 1 0 Biological 19 meiotic cell cycle process -9.40561 4.014315 8.141191 24156 193 873 28 3.207331 0.596329 7|55706|5 4|SMC2|N -6.7159 0 9 0 0 -10.3048 5.16914 46 Processes 6155|800 CAPH|ND 10|81930| C1|TEX14| 83540|84 RMI1|KIF1 057|8469 8A|NUF2| 0|84930|9 MND1|SP 1646|146 ATA22|M 956|1502 ASTL|TDR 80|25926 D12|EME 6 1|HORMA D2|ASPM AGTR2|XI AP|LDLRA 186|331|7 D4|CDH5| 53|1003|1 CDKN2B| 030|2200| FBN1|FBN 2201|224 2|FGF2|H 7|3280|36 ES1|ITGB 90|4052|4 3|LTBP1|S 089|4916| MAD4|NT 6422|642 RK3|SFRP 5|6498|69 1|SFRP5|S 35|7057|9 KIL|ZEB1| GO 508|9719| THBS1|A GO:00902 regulation of cellular response to growth 1 -9.08651 M1 1 0 Biological 19 -9.08651 3.271803 7.615044 24156 296 873 35 4.009164 0.663949 10468|23 DAMTS3| -6.42109 0 6 0 0 -11.8343 3.804639 87 factor stimulus Processes 213|5581 ADAMTS 6|56937|5 L2|FST|SU 7608|641 LF1|DOK5 02|64750| |PMEPA1| 65997|79 JCAD|TN 812|9185 MD|SMU 1|93649|1 RF2|RASL 17166|12 11B|MMR 4857|147 N2|CHRD 372|3755 L1|MYOC 67 D|WFIKK N1|WFIKK N2|CCBE VEGFD|IT GO 2277|369 GO:00051 platelet-derived growth factor receptor GB3|PDG 1 -3.86884 M1 1 0 Molecular 21 -3.86884 9.223368 6.168916 24156 15 873 5 0.572738 0.255402 0|5156|57 -2.01978 0 60 0 0 -4.57507 9.223368 61 binding FRA|PTPR Functions 95|56034 J|PDGFC 196|639|6 AHR|PRD 55|672|94 M1|BMP7 7|1003|12 |BRCA1|C 89|1295|1 D34|CDH 306|1490| 5|COL5A1 1545|187 |COL8A1| 0|2047|20 COL15A1| 48|2247|2 CCN2|CY 277|2307| P1B1|E2F 2324|233 2|EPHB1| 5|3280|36 EPHB2|FG 90|4017|4 F2|VEGFD 052|4208| |FOXS1|FL GO 5125|515 T4|FN1|H GO:00015 1 -9.08083 M1 1 0 Biological 19 blood vessel development -9.08083 2.279133 7.017857 24156 777 873 64 7.331042 0.882151 6|5175|52 ES1|ITGB -6.42109 0 15 1 1 -9.08083 2.73285 68 Processes 28|5587|5 3|LOXL2|L 629|6095| TBP1|MEF 6422|669 2C|PCSK5 2|6915|70 |PDGFRA| 57|7058|7 PECAM1| 075|7852| PGF|PRK 8325|885 D1|PROX 4|9723|10 1|RORA|S 266|1041 FRP1|SPI 3|10454|1 NT1|TBXA 0516|110 2R|THBS1 82|11174| |THBS2|TI 23213|23 E1|CXCR4 414|2898 |FZD8|AL ACTC1|A DORA2A| 70|135|72 C4A|CNN 0|1266|13 3|COMT|S 12|1317|1 LC31A1|C 393|1600| RHBP|DA 2048|217 B1|EPHB2 3|2890|36 |FABP7|G 72|3759|4 RIA1|ITG 155|5179| A1|KCNJ2 5563|578 |MBP|PEN 3|6017|64 K|PRKAA2 56|6790|7 |PTPN13| GO 054|7074| RLBP1|SH GO:00442 Cellular 1 -3.84134 M1 1 0 20 cell body -3.84134 1.873497 4.10858 24156 576 873 39 4.467354 0.699188 7133|877 3GL2|AUR -1.9972 0 41 0 0 -5.7705 2.075258 97 Compone 2|9312|10 KA|TH|TIA nts 891|1134 M1|TNFR 6|22974|2 SF1B|FAD 3237|544 D|KCNB2| 64|57165| PPARGC1 57537|57 A|SYNPO| 565|8468 TPX2|ARC 7|85397|8 |XRN1|GJ 5442|135 C2|SORC 138|3394 S2|KLHL1 79|72923 4|PPP1R9 0 B|RGS8|K NDC1|PA CRG|BRIN 580|655|6 BARD1|B 72|699|70 MP7|BRC 1|835|899 A1|BUB1| |983|1021 BUB1B|C |1030|106 ASP2|CC 3|2273|26 NF|CDK1| 19|2620|3 CDK6|CD 624|3664| KN2B|CE 3976|436 NPF|FHL1 1|4751|49 |GAS1|GA 98|5563|5 S2|INHBA 629|5931| |IRF6|LIF| 6241|649 MRE11|N GO 8|6790|70 EK2|ORC1 GO:00457 1 -8.59294 M1 1 0 Biological 19 negative regulation of cell cycle -8.59294 2.389098 6.879937 24156 637 873 55 6.300115 0.822312 29|7057|7 |PRKAA2| -5.95439 0 4 0 0 -18.6968 4.032327 86 Processes 153|7272| PROX1|R 7465|831 BBP7|RR 7|8318|87 M2|SKIL|A 26|9232|9 URKA|TF 319|9585| DP2|THBS 9587|104 1|TOP2A| 03|27085| TTK|WEE1 28984|51 |CDC7|CD 512|5151 C45|EED| 4|55031|5 PTTG1|TR 6155|568 IP13|KIF2 90|57165| 0B|MAD2 63967|79 L1BP|ND 366|7964 C80|MTB XIAP|CA 331|815|1 MK2A|CC 490|4089| N2|SMAD Canonical 6498|104 1 -3.84112 M286 M1 1 0 11 PID TGFBR PATHWAY -3.84112 4.527835 5.071813 24156 55 873 9 1.030928 0.341867 4|SKIL|YA -1.9972 0 55 0 0 -4.87217 18.44674 Pathways 13|10454| P1|TAB1|S 64750|10 MURF2|O 0506658 CLN ADORA2 135|720|7 A|C4A|CA 94|1131|1 LB2|CHR 312|1385| M3|COM 1393|139 T|CREB1| 5|2047|20 CRHBP|C 48|2890|2 RHR2|EP 902|2913| HB1|EPH 3673|373 B2|GRIA1| 9|4155|49 GRIN1|GR 02|4916|5 M3|ITGA2 010|5179| |KCNA4| 5563|632 MBP|NRT GO 8|6790|70 N|NTRK3| GO:00304 Cellular 1 -3.83907 M1 1 0 20 axon -3.83907 1.824402 4.083107 24156 637 873 42 4.810997 0.724275 54|7074|7 CLDN11| -1.9972 0 86 1 1 -3.83907 2.396623 24 Compone 133|8492| PENK|PRK nts 9585|103 AA2|SCN 69|10590| 3A|AURK 11141|22 A|TH|TIA 974|2413 M1|TNFR 7|57165|5 SF1B|PRS 7616|846 S12|KIF20 87|91624| B|CACNG 91653|12 2|SCGN|IL 6731|222 1RAPL1|T 256|3420 PX2|KIF4 35|34773 A|GJC2|TS 0 HZ3|PPP1 R9B|NEX BRCA2|B UB1|BUB1 675|699|7 B|CKS2|LI 01|1164|3 F|MRE11| 976|4361| MYBL1|N 4603|475 EK2|AURK 1|6790|71 A|TOP2A| 53|7272|9 TTK|CCN 134|9156| E2|EXO1| 9232|931 PTTG1|TR 9|10051|1 GO IP13|SMC GO:00513 0592|233 1 -8.57865 M1 1 0 Biological 19 meiotic cell cycle -8.57865 3.417423 7.454806 24156 251 873 31 3.550974 0.626348 4|SMC2|N -5.94694 0 9 0 0 -10.3048 5.16914 21 97|55706| Processes CAPH|ND 56155|80 C1|TEX14| 010|8193 RMI1|KIF1 0|83540|8 8A|NUF2| 4057|846 MND1|SP 90|84930| ATA22|M 85417|91 ASTL|CC 646|1469 NB3|TDR 56|15028 D12|EME 0|259266 1|HORMA D2|ASPM LDLRAD4| CDH5|CD KN2B|CRE 753|1003| B1|FBN1| 1030|138 FBN2|LTB 5|2200|22 P1|LTBP2| 01|4052|4 SMAD4|S 053|4089| MAD5|M 4090|420 EF2C|PEN 8|5179|64 K|SFRP1|S 22|6498|6 KIL|ZEB1| 935|7057| GO THBS1|CI GO:00715 response to transforming growth factor 8483|971 1 -8.49472 M1 1 0 Biological 19 -8.49472 3.390408 7.401117 24156 253 873 31 3.550974 0.626348 LP|ADAM -5.87426 0 6 0 0 -11.8343 3.804639 59 beta 9|10454|1 Processes TSL2|TAB 0631|108 1|POSTN| 91|25878| PPARGC1 27063|56 A|MXRA5| 937|6475 ANKRD1| 0|65997|8 PMEPA1| 0326|936 SMURF2| 49|11716 RASL11B| 6|124857| WNT10A| 642658 MYOCD| WFIKKN1| WFIKKN2| 88|672|89 ACTN2|B 9|1003|14 RCA1|CC 90|1894|2 NF|CDH5| 824|3832| CCN2|EC 4089|420 T2|GPM6 8|4233|47 B|KIF11|S 51|4916|5 MAD4|M 156|5563| EF2C|MET 5629|638 |NEK2|NT 7|6422|64 RK3|PDGF 91|6790|7 RA|PRKA 456|9723| A2|PROX 10460|10 1|CXCL12 GO 733|1078 |SFRP1|ST GO:00514 1 -8.4679 M1 1 0 Biological 19 regulation of cytoskeleton organization -8.4679 2.492802 6.889294 24156 555 873 50 5.727377 0.786436 8|11346|2 IL|AURKA| -5.86252 0 8 0 0 -11.3911 5.158833 93 Processes 2843|229 WIPF1|SE 74|22998| MA3E|TA 23433|25 CC3|PLK4 886|2658 |IQGAP2| 6|28984|2 SYNPO|P 9766|508 PM1E|TP 53|55835| X2|LIMCH 56890|57 1|RHOQ| 159|5738 POC1A|C 1|60312|7 KAP2|RG 9648|798 CC|TMO 66|81930| D3|VILL|C 84952|85 ENPJ|MD 459|9162 M1|TRIM BIRC5|CE 332|1062| NPE|KIF1 3832|475 1|NEK2|P 1|5116|64 CNT|STIL| 91|6790|7 AURKA|T 272|9493| TK|KIF23| 10403|10 NDC80|T GO 460|2297 GO:19028 microtubule cytoskeleton organization ACC3|TPX 1 -8.24236 M1 1 0 Biological 19 -8.24236 4.379441 7.737204 24156 139 873 22 2.520046 0.530463 4|24137|2 -5.65572 0 8 0 0 -11.3911 5.158833 50 involved in mitosis 2|KIF4A|P Processes 5886|512 OC1A|NU 03|54820| SAP1|ND 55125|57 E1|CEP19 405|7964 2|SPC25| 8|79866|8 MCPH1|B 3540|126 ORA|NUF 731 2|CCSAP 4175|499 MCM6|O 8|4999|55 RC1|ORC R-HSA- Reactome 1 -3.83123 M1 1 0 6 Activation of the pre-replicative complex -3.83123 5.869416 5.420126 24156 33 873 7 0.801833 0.301847 58|8317|8 2|PRIM2| -1.9944 0 20 0 0 -7.69554 7.546392 68962 Gene Sets 318|5538 CDC7|CD 8 C45|MCM BARD1|B 580|672|6 RCA1|BR R-HSA- Reactome Resolution of D-loop Structures through 75|4361|9 1 -3.83123 M1 1 0 6 -3.83123 5.869416 5.420126 24156 33 873 7 0.801833 0.301847 CA2|MRE -1.9944 0 70 0 0 -4.32747 27.6701 5693568 Gene Sets Holliday Junction Intermediates 156|8001 11|EXO1| 0|146956 RMI1|EM LDLRAD4| CDH5|CD 753|1003| KN2B|CRE 1030|138 B1|FBN1| 5|2200|22 FBN2|LTB 01|4052|4 P1|LTBP2| 053|4089| SMAD4|S 4090|420 MAD5|M 8|5179|64 EF2C|PEN 22|6498|6 K|SFRP1|S 935|7057| KIL|ZEB1| GO GO:00715 cellular response to transforming growth 8483|971 THBS1|CI 1 -8.1521 M1 1 0 Biological 19 -8.1521 3.360741 7.221166 24156 247 873 30 3.436426 0.616528 -5.58344 0 6 0 0 -11.8343 3.804639 60 factor beta stimulus 9|10454|1 LP|ADAM Processes 0631|108 TSL2|TAB 91|27063| 1|POSTN| 56937|64 PPARGC1 750|6599 A|ANKRD 7|80326|9 1|PMEPA 3649|117 1|SMURF 166|1248 2|RASL11 57|64265 B|WNT10 8 A|MYOC D|WFIKK N1|WFIKK BMP7|CR HBP|FGF2 655|1393| |VEGFD|I 2247|227 NHBA|LIF| 7|3624|39 NRTN|PG 76|4902|5 F|CXCL12| 228|6387| SFRP1|SF 6422|642 RP5|TNFS 5|8743|95 F10|CXCL 47|9966|1 14|TNFSF 0468|259 Canonical 15|FST|EG 1 -3.82915 M5883 M1 1 0 11 NABA SECRETED FACTORS -3.82915 2.171781 4.238567 24156 344 873 27 3.092784 0.58593 75|51129| -1.9944 0 21 0 0 -7.62485 2.171781 Pathways FL6|ANGP 56034|80 TL4|PDGF 326|9185 C|WNT10 1|117166| A|CHRDL 124857|1 1|WFIKKN 47372|22 1|WFIKKN 2663|339 2|CCBE1| 479|3755 SCUBE3|B 67|72396 RINP3|V 1 WC2|INS- IGF2 86|220|63 ACTL6A|A 9|655|835 LDH1A3| |1289|129 PRDM1|B 5|1545|20 MP7|CAS 47|2048|2 P2|COL5 103|2200| A1|COL8 2201|253 A1|CYP1B 5|3280|36 1|EPHB1| 24|4237|4 EPHB2|ES 610|4916| RRB|FBN1 5156|530 |FBN2|FZ 8|5629|64 D2|HES1|I 98|6935|6 NHBA|MF GO 939|7054| AP2|MYC GO:00074 1 -8.05127 M1 1 0 Biological 19 sensory organ development -8.05127 2.447356 6.673396 24156 554 873 49 5.612829 0.779005 8854|942 L|NTRK3| -5.48844 0 7 0 0 -11.4306 6.148912 23 Processes 3|9497|95 PDGFRA| 47|10736| PITX2|PR 11081|30 OX1|SKIL| 812|5114 ZEB1|TCF 1|53904|5 15|TH|AL 4567|568 DH1A2|N 90|57381| TN1|SLC4 64072|80 A7|CXCL1 184|8032 4|SIX2|KE 6|91851|1 RA|SOX8|I 16039|11 NSIG2|M 7531|133 YO3A|DLL 060|1575 4|MDM1| 06|17069 RHOJ|CD BMP7|BR CA1|BUB 655|672|6 1|BUB1B| 99|701|83 CASP2|C 5|899|983 CNF|CDK |1021|103 1|CDK6|C 0|1063|22 DKN2B|C 73|3976|4 ENPF|FHL 361|4751| 1|LIF|MRE 4998|593 11|NEK2| 1|6241|67 ORC1|RB 90|7029|7 GO BP7|RRM GO:00109 272|7465| 1 -7.98699 M1 1 0 Biological 19 negative regulation of cell cycle process -7.98699 2.86777 6.88445 24156 357 873 37 4.238259 0.68184 2|AURKA| -5.42991 0 4 0 0 -18.6968 4.032327 48 8317|872 Processes TFDP2|TT 6|9232|93 K|WEE1|C 19|10403| DC7|EED| 27085|28 PTTG1|TR 984|5151 IP13|NDC 2|51514|5 80|MTBP| 5031|561 RGCC|GT 55|56890| SE1|DTL| 57165|63 USP47|TE 967|7936 X14|MDM 6|144455 1|GJC2|CL SPN|HMG 136|238|8 ADORA2 94|983|10 B|ALK|CC 62|1164|1 ND2|CDK 600|1849| 1|CENPE| 1894|190 CKS2|DA 8|2047|20 B1|DUSP7 48|2247|2 |ECT2|ED 324|3357| N3|EPHB 3672|369 1|EPHB2| 0|4214|42 FGF2|FLT 33|4361|4 4|HTR2B|I 916|5156| TGA1|ITG 5587|560 B3|MAP3 GO 0|5629|70 K1|MET| GO:00336 1 -7.89792 M1 1 0 Biological 19 positive regulation of kinase activity -7.89792 2.347219 6.542275 24156 613 873 52 5.956472 0.801036 57|7074|7 MRE11|N -5.34652 0 18 1 1 -7.89792 2.69514 74 Processes 075|7520| TRK3|PD 7852|832 GFRA|PRK 5|8543|87 D1|MAPK 67|9928|9 11|PROX1 966|1012 |THBS1|TI 5|10454|2 AM1|TIE1 2974|289 |XRCC5|C 84|29969| XCR4|FZD 54757|54 8|LMO4|R 892|5603 IPK2|KIF1 4|63967|7 4|TNFSF1 9444|798 5|RASGRP 66|15211 1|TAB1|T 0|284656| PX2|RGC BRCA1|BR 672|675|8 CA2|CCN 99|983|38 F|CDK1|KI 32|4751|6 F11|NEK2 491|6790| |STIL|AUR 9648|966 KA|GCC2| 2|10733|2 GO CEP135|P GO:00310 5886|548 1 -7.81934 M1 1 0 Biological 19 microtubule organizing center organization -7.81934 4.336359 7.499146 24156 134 873 21 2.405498 0.518571 LK4|POC1 -5.27355 0 19 1 1 -7.81934 13.83505 23 20|55125| Processes A|NDE1|C 55835|56 EP192|CE 890|7944 NPJ|MDM 1|79648|8 1|HAUS3| 4612|854 MCPH1|P 59|11717 ARD6B|C 8 EP295|SS THBS1|TH BS2|ADA 7057|705 MTS3|AD 8|9508|97 AMTSL2| 19|11174| ADAMTS R-HSA- Reactome Diseases associated with O-glycosylation of 1 -3.80378 M1 1 0 6 -3.80378 4.069133 4.907507 24156 68 873 10 1.145475 0.360151 54437|55 6|SEMA5 -1.97609 0 33 0 0 -6.2858 7.478406 3906995 Gene Sets proteins 901|5718 B|THSD1| 8|80731|1 ADAMTS 70692 L3|THSD7 B|ADAMT S18 136|238|8 ADORA2 94|983|10 B|ALK|CC 62|1164|1 ND2|CDK 600|1849| 1|CENPE| 1894|190 CKS2|DA 8|2047|20 B1|DUSP7 48|2247|2 |ECT2|ED 324|3357| N3|EPHB 3672|369 1|EPHB2| 0|4214|42 FGF2|FLT 33|4361|4 4|HTR2B|I 751|4916| TGA1|ITG 5073|515 B3|MAP3 GO 6|5587|56 K1|MET| GO:00513 1 -7.74324 M1 1 0 Biological 19 positive regulation of transferase activity -7.74324 2.239199 6.404486 24156 692 873 56 6.414662 0.829247 00|5629|7 MRE11|N -5.20844 0 18 0 0 -7.89792 2.69514 47 Processes 057|7074| EK2|NTRK 7075|752 3|PARN|P 0|7852|83 DGFRA|P 25|8543|8 RKD1|MA 767|9928| PK11|PRO 9966|101 X1|THBS1 25|10454| |TIAM1|TI 22974|28 E1|XRCC5 984|2996 |CXCR4|F 9|54757|5 ZD8|LMO 4892|560 4|RIPK2|KI 34|63967| F14|TNFS 79075|79 F15|RASG 444|7986 RP1|TAB1 332|1062| BIRC5|CE 3832|475 NPE|KIF1 1|5116|64 1|NEK2|P 91|6790|7 CNT|STIL| 272|9493| AURKA|T GO 10403|10 TK|KIF23| GO:00070 1 -7.71092 M1 1 0 Biological 19 mitotic spindle organization -7.71092 4.694035 7.587485 24156 112 873 19 2.176403 0.493838 460|2297 NDC80|T -5.18151 0 8 0 0 -11.3911 5.158833 52 Processes 4|24137|2 ACC3|TPX 5886|551 2|KIF4A|P 25|57405| OC1A|CE 79866|83 P192|SPC 540|1267 25|BORA| 31 NUF2|CC HABP2|L OXL2|MM P1|MMP7 3026|401 |PCSK5|SE 7|4312|43 RPINE2|TI 16|5125|5 MP3|TIM 270|7078| P4|TLL2|P 7079|709 RSS12|AD 3|8492|95 AMTS3|A Canonical 08|9719|1 1 -3.79065 M3468 M1 1 0 11 NABA ECM REGULATORS -3.79065 2.44148 4.327387 24156 238 873 21 2.405498 0.518571 DAMTSL2 -1.96448 0 88 1 1 -3.79065 3.532354 Pathways 1174|232 |ADAMTS 13|54757| 6|SULF1|F 55214|57 AM20A|P 188|6406 3H2|ADA 6|79148|8 MTSL3|M 0760|170 MP27|M 692 MP28|ITI H5|ADAM TS18 186|220|6 AGTR2|AL 55|1289|2 DH1A3|B 239|2247| MP7|COL 2535|328 5A1|GPC4 0|3909|39 |FGF2|FZ 76|4089|4 D2|HES1| 208|4233| LAMA3|LI 5228|542 F|SMAD4| 0|5629|64 MEF2C|M 22|6491|6 ET|PGF|P 692|6939| ODXL|PR 7074|785 OX1|SFRP 2|8543|88 1|STIL|SPI GO 54|9096|9 NT1|TCF1 GO:00020 1 -7.69193 M1 1 0 Biological 19 morphogenesis of an epithelium -7.69193 2.410463 6.485248 24156 551 873 48 5.498282 0.771483 423|9585| 5|TIAM1| -5.17312 0 10 0 0 -10.1376 3.952872 09 Processes 9645|972 CXCR4|L 3|10413|1 MO4|ALD 0468|107 H1A2|TBX 36|23213| 18|NTN1| 30812|51 KIF20B|MI 098|5456 CAL2|SE 7|57619|6 MA3E|YA 4750|801 P1|FST|SI 84|80326| X2|SULF1| 131405|1 SOX8|IFT 44165|15 52|DLL4|S 7506|284 HROOM3 217|3398 |SMURF2| 29|34041 CEP290| BRCA1|BR 672|675|8 CA2|CCN 99|983|38 F|CDK1|KI 32|4751|6 F11|NEK2 491|6790| |STIL|AUR 9662|107 KA|CEP13 GO 33|25886| 5|PLK4|P GO:00070 1 -7.6346 M1 1 0 Biological 19 centrosome cycle -7.6346 4.427216 7.438781 24156 125 873 20 2.290951 0.50637 54820|55 OC1A|ND -5.12099 0 19 0 0 -7.81934 13.83505 98 Processes 125|5583 E1|CEP19 5|56890|7 2|CENPJ| 9441|796 MDM1|H 48|84612| AUS3|MC 85459|11 PH1|PAR 7178 D6B|CEP2 95|SSX2IP BUB1|BU 699|701|4 B1B|MRE 361|7153| 11|TOP2A 7272|913 |TTK|CCN 4|9232|93 E2|PTTG1 GO 19|10051| |TRIP13|S GO:00451 1 -7.61108 M1 1 0 Biological 19 meiotic chromosome segregation -7.61108 5.16914 7.715524 24156 91 873 17 1.947308 0.467671 10592|23 MC4|SMC -5.10768 0 9 0 0 -10.3048 5.16914 32 Processes 397|5570 2|NCAPH| 6|80010|8 NDC1|RM 3540|846 I1|NUF2|S 90|14695 PATA22|E 6|150280 ME1|HOR MAD2 XIAP|BMP 7|LDLRAD 331|655|7 4|CDH5|C 53|1003|1 DKN2B|F 030|2200| BN1|FBN 2201|328 2|HES1|IN 0|3624|40 HBA|LTBP 52|4089|6 1|SMAD4| 422|6425| SFRP1|SF 6498|693 RP5|SKIL| GO regulation of transmembrane receptor GO:00900 5|7057|72 ZEB1|THB 1 -7.57113 M1 1 0 Biological 19 protein serine/threonine kinase signaling -7.57113 3.248717 6.878499 24156 247 873 29 3.321879 0.606525 -5.07355 0 6 0 0 -11.8343 3.804639 92 72|8483|9 S1|TTK|CI Processes pathway 719|1046 LP|ADAM 8|23213|5 TSL2|FST| 6937|647 SULF1|PM 50|65997| EPA1|SM 91851|93 URF2|RAS 649|1171 L11B|CHR 66|12485 DL1|MYO 7|375567 CD|WFIKK N1|WFIKK N2|VWC2 BRCA1|B UB1|BUB1 672|699|7 B|CASP2| 01|835|98 CDK1|CD 3|1030|10 KN2B|CE 63|4361|4 NPF|MRE 998|6790| 11|ORC1| 7029|715 GO AURKA|TF GO:00070 3|7272|74 1 -7.51044 M1 1 0 Biological 19 mitotic cell cycle checkpoint -7.51044 3.857045 7.130599 24156 165 873 23 2.634593 0.542066 DP2|TOP -5.02679 0 4 0 0 -18.6968 4.032327 93 65|9319|9 Processes 2A|TTK|W 587|1040 EE1|TRIP1 3|28984|5 3|MAD2L 1512|561 1BP|NDC 55|63967| 80|RGCC| 144455|1 GTSE1|TE 46956 X14|CLSP N|E2F7|E 672|899|1 BRCA1|C 003|3832| CNF|CDH 4233|475 5|KIF11|M 1|5563|64 ET|NEK2| 91|6790|1 PRKAA2|S 0460|107 TIL|AURK 33|22974| A|TACC3| 25886|26 PLK4|TPX GO GO:00705 regulation of microtubule cytoskeleton 586|5583 2|POC1A| 1 -7.50182 M1 1 0 Biological 19 -7.50182 3.602878 7.011581 24156 192 873 25 2.863688 0.564477 -5.02297 0 8 0 0 -11.3911 5.158833 07 organization 5|56890|5 CKAP2|CE Processes 7159|796 NPJ|MDM 48|79866| 1|TRIM54| 81930|85 MCPH1|B 459|1267 ORA|KIF1 31|22115 8A|CEP29 0|246176| 5|CCSAP| 10050665 SKA3|GAS 8 2L2|OCL AGTR2|B 186|655|2 MP7|FGF 247|2535| 2|FZD2|H 3280|408 ES1|SMA 9|4208|42 D4|MEF2 33|5228|5 C|MET|PG 420|5629| F|PODXL| 6422|649 PROX1|SF 1|6692|78 RP1|STIL| 52|8543|9 SPINT1|C 423|9585| XCR4|LM GO 9645|972 O4|NTN1| GO:00605 1 -7.42535 M1 1 0 Biological 19 epithelial tube morphogenesis -7.42535 2.877014 6.617281 24156 327 873 34 3.894616 0.654786 3|10413|1 KIF20B|MI -4.95594 0 10 0 0 -10.1376 3.952872 62 Processes 0736|308 CAL2|SE 12|51098| MA3E|YA 54567|57 P1|SIX2|S 619|8018 OX8|IFT5 4|131405| 2|DLL4|S 144165|1 HROOM3 57506|28 |CEP290|T 4217|339 RIM71|PR 829|3404 ICKLE1|R 19|44147 DH10|LA 8 MA1|CCD C39|RSPO BARD1|B 580|672|6 RCA1|BR 75|983|18 CA2|CDK 54|4175|4 1|DUT|M 361|4998| CM6|MRE 4999|555 11|ORC1| 8|5931|62 ORC2|PRI 41|7270|8 M2|RBBP 208|8317| 7|RRM2|T GO 8318|913 GO:00062 TF1|CHAF 1 -7.26446 M1 1 0 Biological 19 DNA replication -7.26446 3.074456 6.637516 24156 270 873 30 3.436426 0.616528 4|9156|51 -4.81334 0 20 0 0 -7.69554 7.546392 60 1B|CDC7| Processes 514|5538 CDC45|C 8|63967|7 CNE2|EX 9075|800 O1|DTL|M 10|80119| CM10|CL 80169|92 SPN|DSC 667|1444 C1|RMI1| 55|14695 PIF1|CTC 6|254394| 1|MGME1 353497 |E2F7|EM AGTR2|B MP7|CD3 186|655|9 4|CENPF| 47|1063|2 FBN1|FGF 200|2247| 2|HES1|LI 3280|397 F|SMAD4| 6|4089|40 SMAD5| 90|4208|5 MEF2C|P 125|5156| CSK5|PD 5175|522 GFRA|PEC GO 8|5420|54 GO:00720 AM1|PGF| 1 -7.03102 M1 1 0 Biological 19 renal system development -7.03102 2.937579 6.45016 24156 292 873 31 3.550974 0.626348 71|5629|6 -4.60764 0 10 0 0 -10.1376 3.952872 01 PODXL|P Processes 422|8772| PAT|PRO 8854|909 X1|SFRP1| 6|9104|10 FADD|AL 413|1073 DH1A2|T 6|23213|3 BX18|RG 0812|801 N|YAP1|SI 84|93649| X2|SULF1| 116039|1 SOX8|CEP 57506 290|MYO CD|OSR2| XIAP|BMP 7|LDLRAD 331|655|7 4|CDH5|C 53|1003|1 DKN2B|C 030|1385| REB1|FBN 2200|220 1|FBN2|H 1|3280|36 ES1|INHB 24|4052|4 A|LTBP1|L 053|4089| TBP2|SM 4090|642 AD4|SMA 2|6425|64 D5|SFRP1 98|6935|7 |SFRP5|SK GO GO:00071 transmembrane receptor protein 057|7272| IL|ZEB1|T 1 -7.01862 M1 1 0 Biological 19 -7.01862 2.720375 6.332146 24156 356 873 35 4.009164 0.663949 -4.60361 0 6 0 0 -11.8343 3.804639 78 serine/threonine kinase signaling pathway 8483|971 HBS1|TTK Processes 9|10454|1 |CILP|AD 0468|232 AMTSL2|T 13|56937| AB1|FST|S 56963|64 ULF1|PME 750|6599 PA1|RGM 7|91851|9 A|SMURF 3649|117 2|RASL11 166|1248 B|CHRDL 57|37556 1|MYOCD 7|642658 |WFIKKN1 |WFIKKN2 |VWC2|SC BRCA1|B UB1|BUB1 672|699|7 B|CASP2| 01|835|98 CDK1|CD 3|1030|10 KN2B|CE 63|4361|4 NPF|MRE 998|5629| 11|ORC1| 6790|702 PROX1|A 9|7153|72 GO URKA|TF GO:00000 72|7465|8 1 -6.99223 M1 1 0 Biological 19 cell cycle checkpoint -6.99223 3.300104 6.605763 24156 218 873 26 2.978236 0.575317 DP2|TOP -4.58776 0 4 0 0 -18.6968 4.032327 75 318|9319| Processes 2A|TTK|W 9587|104 EE1|CDC4 03|28984| 5|TRIP13| 51512|51 MAD2L1B 514|5615 P|NDC80| 5|63967|1 RGCC|GT 44455|14 SE1|DTL|T 6956 EX14|CLS PN|E2F7|E 70|88|186 ACTC1|A |983|1063 CTN2|AG |1134|138 TR2|CDK1 5|1841|20 |CENPF|C 47|2247|2 HRNA1|C 273|2275| REB1|DTY 2535|328 MK|EPHB 0|3976|40 1|FGF2|F 89|4208|4 HL1|FHL3 772|5081| |FZD2|HE 5156|560 S1|LIF|SM 0|5629|60 AD4|MEF 95|6445|6 2C|NFAT GO 935|6939| C1|PAX7| GO:00610 1 -6.91421 M1 1 0 Biological 19 muscle structure development -6.91421 2.169402 5.971441 24156 676 873 53 6.071019 0.808209 7093|713 PDGFRA| -4.51374 0 13 0 0 -9.83559 6.28866 61 Processes 5|7139|71 MAPK11| 40|9242|9 PROX1|R 547|1026 ORA|SGC 6|10324|1 G|ZEB1|T 0413|105 CF15|TLL 29|23414| 2|TNNI1|T 27063|27 NNT2|TN 295|2976 NT3|MSC| 6|30812|5 CXCL14|R 4567|574 AMP2|KL 86|57538| HL41|YAP 58494|64 1|NEBL|ZF 091|9165 PM2|ANK 3|93649|1 RD1|PDLI BARD1|B 580|672|6 RCA1|BR R-HSA- Reactome 75|4361|9 1 -3.74477 M1 1 0 6 Resolution of D-Loop Structures -3.74477 5.696786 5.306703 24156 34 873 7 0.801833 0.301847 CA2|MRE -1.93219 0 70 0 0 -4.32747 27.6701 5693537 Gene Sets 156|8001 11|EXO1| 0|146956 RMI1|EM 86|639|65 ACTL6A|P 5|672|675 RDM1|B |2103|253 MP7|BRC 5|3280|39 A1|BRCA2 76|4089|4 |ESRRB|FZ 208|4222| D2|HES1| 4751|508 LIF|SMAD 1|5125|51 4|MEF2C| 56|5629|6 MEOX1|N 422|6491| EK2|PAX7 6498|669 |PCSK5|P 2|6935|69 DGFRA|P 39|7075|8 ROX1|SFR GO 543|8854| P1|STIL|S GO:00430 1 -6.76747 M1 1 0 Biological 19 chordate embryonic development -6.76747 2.184482 5.908939 24156 646 873 51 5.841924 0.793779 9096|913 KIL|SPINT -4.38265 0 26 1 1 -6.76747 2.184482 09 Processes 3|9508|95 1|ZEB1|TC 85|10454| F15|TIE1|L 10733|10 MO4|ALD 736|2321 H1A2|TBX 3|23414|2 18|CCNB 7022|308 2|ADAMT 12|51098| S3|KIF20B 51294|54 |TAB1|PLK 892|5511 4|SIX2|SU 2|57619|5 LF1|ZFPM 7718|116 2|FOXD3| 039|1314 SOX8|IFT 05|14416 52|PCDH 5|144455| 12|NCAP BRCA1|C 672|899|1 CNF|CDH 003|3832| 5|KIF11|M 4233|475 ET|NEK2| 1|5563|64 PRKAA2|S 91|6790|1 TIL|AURK 0460|107 A|TACC3| 33|22974| PLK4|TPX 25886|26 GO 2|POC1A| GO:00328 586|5583 1 -6.75604 M1 1 0 Biological 19 regulation of microtubule-based process -6.75604 3.211708 6.439521 24156 224 873 26 2.978236 0.575317 CKAP2|CE -4.37505 0 8 0 0 -11.3911 5.158833 86 5|56890|5 Processes NPJ|MDM 7159|796 1|TRIM54| 48|79866| MCPH1|B 81930|85 ORA|KIF1 459|1267 8A|CEP29 31|22115 5|CCSAP| 0|246176| SKA3|GAS 339829|1 2L2|CCDC 00506658 39|OCLN 10403|57 NDC80|S CORUM:1 1 -3.73731 M1 1 0 CORUM 33 NDC80 kinetochore complex -3.73731 20.75258 7.650123 24156 4 873 3 0.343643 0.198061 405|8354 PC25|NU -1.92882 0 91 0 0 -3.73731 20.75258 27 0 F2 GO 10403|57 NDC80|S GO:00312 Cellular 1 -3.73731 M1 1 0 20 Ndc80 complex -3.73731 20.75258 7.650123 24156 4 873 3 0.343643 0.198061 405|8354 PC25|NU -1.92882 0 91 1 1 -3.73731 20.75258 62 Compone 0 F2 nts GO COL4A5| 1287|128 GO:00986 Cellular COL4A6| 1 -3.73382 M1 1 0 20 basement membrane collagen trimer -3.73382 12.29782 6.564107 24156 9 873 4 0.45819 0.22857 8|1295|13 -1.92772 0 5 0 0 -15.2617 12.29782 51 Compone COL8A1| 06 nts COL15A1 BMP7|BR 655|672|6 CA1|BUB 99|701|83 1|BUB1B| 5|983|102 CASP2|C 1|1030|10 DK1|CDK 63|2273|2 6|CDKN2 619|4361| B|CENPF| 4998|679 FHL1|GAS 0|7029|71 1|MRE11| 53|7272|7 ORC1|AU GO 465|9232| RKA|TFDP GO:00459 1 -6.52522 M1 1 0 Biological 19 negative regulation of mitotic cell cycle -6.52522 2.685628 6.06119 24156 340 873 33 3.780069 0.645469 9319|958 2|TOP2A| -4.16679 0 4 0 0 -18.6968 4.032327 30 Processes 7|10403|2 TTK|WEE1 7085|289 |PTTG1|T 84|51512| RIP13|MA 55031|56 D2L1BP|N 155|5716 DC80|MT 5|63967|7 BP|RGCC| 9648|144 GTSE1|US 455|1469 P47|TEX1 56|33947 4|GJC2|CL 9 SPN|MCP H1|E2F7|E ACTC1|B MP7|LDL 70|655|75 RAD4|ED 3|1908|23 N3|FN1|H 35|3280|3 ES1|HTR2 357|4017| B|LOXL2| 4089|420 SMAD4| 8|4222|49 MEF2C|M 02|5308|6 EOX1|NR 422|6939| TN|PITX2| GO 7074|885 GO:00604 SFRP1|TC 1 -6.45792 M1 1 0 Biological 19 mesenchyme development -6.45792 2.88645 6.125758 24156 278 873 29 3.321879 0.606525 4|9723|10 -4.10639 0 28 1 1 -6.45792 4.716495 85 F15|TIAM Processes 413|1073 1|ALDH1 6|23414|2 A2|SEMA 8984|308 3E|YAP1|S 12|80326| IX2|ZFPM 157506|2 2|RGCC|S 02151|20 OX8|WNT 5717|359 10A|RDH 845|6426 10|RANB 58 P3L|USF3| RFLNB|SC ALDH1A3 |PRDM1|B 220|639|6 MP7|EPH 55|2048|2 B2|ESRRB| 103|2200| FBN1|FBN 2201|253 2|FZD2|H 5|3280|39 ES1|LIF|M 76|4208|4 EF2C|MF 237|5125| AP2|PCSK 5156|562 5|PDGFR 9|6491|66 A|PROX1| 92|6935|7 STIL|SPIN 054|8854| T1|ZEB1|T GO 9423|964 GO:00485 H|ALDH1 1 -6.4301 M1 1 0 Biological 19 embryonic organ development -6.4301 2.42502 5.875127 24156 445 873 39 4.467354 0.699188 5|10413|1 -4.08229 0 7 0 0 -11.4306 6.148912 68 A2|NTN1| Processes 0733|107 MICAL2|Y 36|23414| AP1|PLK4| 51098|51 SIX2|ZFP 141|5129 M2|IFT52| 4|53904|5 INSIG2|P 5112|560 CDH12|M 34|80184| YO3A|WD 91461|11 R60|PDGF 6039|133 C|CEP290 060|1444 |PKDCC|O 55|15750 SR2|OTO 6|339829 P1|E2F7|R DH10|CC 238|443|6 ALK|ASPA 55|1382|1 |BMP7|CR 600|1789| ABP2|DA 1894|204 B1|DNMT 7|2048|23 3B|ECT2|E 35|2803|3 PHB1|EP 280|3706| HB2|FN1| 3976|420 GOLGA4| 8|4916|51 HES1|ITP 21|5270|5 KA|LIF|ME 587|5629| F2C|NTRK 6387|649 3|PCP4|SE 8|6692|69 RPINE2|P GO 35|7058|7 RKD1|PR GO:00519 positive regulation of nervous system 1 -6.42481 M1 1 0 Biological 19 -6.42481 2.255715 5.779083 24156 552 873 45 5.154639 0.748342 074|7133| OX1|CXC -4.08229 0 29 1 1 -6.42481 3.074456 62 development Processes 7520|785 L12|SKIL|S 2|9423|95 PINT1|ZE 85|11141| B1|THBS2 22871|23 |TIAM1|T 768|2706 NFRSF1B| 3|30812|5 XRCC5|C 4674|571 XCR4|NT 65|15183 N1|KIF20 5|259266| B|IL1RAPL 285016|3 1|NLGN1| 39479|34 FLRT2|AN 7730|375 KRD1|SO 567|7292 X8|LRRN3 30 |GJC2|CP 1062|106 CENPE|CE 3|10051|1 NPF|SMC GO GO:00513 0403|105 4|NDC80| 1 -6.42327 M1 1 0 Biological 19 kinetochore organization -6.42327 10.54099 8.469752 24156 21 873 8 0.91638 0.322501 -4.08229 0 2 0 0 -22.074 10.54099 83 92|55839| SMC2|CE Processes 79003|83 NPN|MIS 540 12|NUF2 GO BUB1|BU 699|701|1 GO:00007 Cellular condensed nuclear chromosome B1B|NDC 1 -3.7192 M1 1 0 20 -3.7192 8.646907 5.924727 24156 16 873 5 0.572738 0.255402 0403|790 -1.91797 0 25 0 0 -7.23866 13.83505 78 Compone kinetochore 80|MIS12| 03|83540 nts NUF2 86|639|65 ACTL6A|P 5|672|675 RDM1|B |2103|253 MP7|BRC 5|3280|39 A1|BRCA2 76|4089|4 |ESRRB|FZ 208|4222| D2|HES1| 4751|508 LIF|SMAD 1|5125|51 4|MEF2C| 56|5629|6 MEOX1|N 422|6491| EK2|PAX7 6498|669 |PCSK5|P 2|6935|69 DGFRA|P 39|7075|8 ROX1|SFR GO 543|8854| P1|STIL|S GO:00097 embryo development ending in birth or 1 -6.40336 M1 1 0 Biological 19 -6.40336 2.125264 5.693373 24156 664 873 51 5.841924 0.793779 9096|913 KIL|SPINT -4.06584 0 26 0 0 -6.76747 2.184482 92 egg hatching Processes 3|9508|95 1|ZEB1|TC 85|10454| F15|TIE1|L 10733|10 MO4|ALD 736|2321 H1A2|TBX 3|23414|2 18|CCNB 7022|308 2|ADAMT 12|51098| S3|KIF20B 51294|54 |TAB1|PLK 892|5511 4|SIX2|SU 2|57619|5 LF1|ZFPM 7718|116 2|FOXD3| 039|1314 SOX8|IFT 05|14416 52|PCDH 5|144455| 12|NCAP ACTL6A|A LDH1A3| PRDM1|B 86|220|63 MP7|CAS 9|655|835 P2|COL5 |1289|129 A1|COL8 5|1545|20 A1|CYP1B 47|2048|2 1|EPHB1| 200|2201| EPHB2|FB 3624|423 N1|FBN2|I 7|4916|51 NHBA|MF 56|5308|5 AP2|NTR GO 629|6498| GO:00016 K3|PDGFR 1 -6.39709 M1 1 0 Biological 19 eye development -6.39709 2.606048 5.953338 24156 361 873 34 3.894616 0.654786 6935|705 -4.06301 0 7 0 0 -11.4306 6.148912 54 A|PITX2|P Processes 4|8854|11 ROX1|SKI 081|3081 L|ZEB1|T 2|54567|5 H|ALDH1 6890|573 A2|KERA| 81|80184| SOX8|DLL 91851|11 4|MDM1| 6039|157 RHOJ|CEP 506|1706 290|CHR 92|28421 DL1|OSR2 7|341640 |RDH10|A DAMTS18 |LAMA1|F AGTR2|B MP7|CD3 186|655|9 4|CENPF| 47|1063|2 EPHB2|FB 048|2200| N1|FGF2| 2247|328 HES1|LIF| 0|3976|40 SMAD4|S 89|4090|4 MAD5|M 208|5125| EF2C|PCS 5156|517 K5|PDGFR 5|5228|54 GO A|PECAM GO:00016 20|5471|5 1 -6.33795 M1 1 0 Biological 19 urogenital system development -6.33795 2.683162 5.961401 24156 330 873 32 3.665521 0.635992 1|PGF|PO -4.014 0 10 0 0 -10.1376 3.952872 55 629|6422| Processes DXL|PPAT 8772|885 |PROX1|S 4|9096|91 FRP1|FAD 04|10413| D|ALDH1 10736|23 A2|TBX18 213|3081 |RGN|YAP 2|80184|9 1|SIX2|SU 3649|116 LF1|SOX8| 039|1575 CEP290| 06 MYOCD| OSR2|RD CAMK2A| CASP2|C 815|835|8 CND2|CD 94|983|10 K1|CDK6| 21|1030|2 CDKN2B| 103|2273| ESRRB|FH 3624|417 L1|INHBA 5|4998|49 |MCM6|O 99|5471|5 RC1|ORC 558|6241| GO 2|PPAT|P GO:00000 6790|702 1 -6.32789 M1 1 0 Biological 19 G1/S transition of mitotic cell cycle -6.32789 2.845507 6.036273 24156 282 873 29 3.321879 0.606525 RIM2|RR -4.00727 0 30 1 1 -6.32789 4.035223 82 9|7465|83 Processes M2|AURK 17|8318|9 A|TFDP2| 134|9928| WEE1|CD 27085|28 C7|CDC4 984|5151 5|CCNE2| 2|55388|5 KIF14|MT 7165|131 BP|RGCC| 405|1444 GTSE1|M 55 CM10|GJ C2|TRIM7 CMKLR1| 1240|284 GPR17|CX 0|7852|91 CR4|OSM 80|26280| R|IL1RAPL GO 50615|51 GO:00048 2|IL21R|A 1 -3.70842 M1 1 0 Molecular 21 cytokine receptor activity -3.70842 3.423106 4.630316 24156 97 873 12 1.37457 0.394068 554|5383 -1.91201 0 93 1 1 -3.70842 5.321174 96 CKR4|IL20 Functions 2|54756|3 RA|IL17R 89400|40 D|GFRAL|I 0935|729 L17REL|C 230 CR2 CENPE|CE 1062|106 NPF|CEN 3|2491|30 PI|HELLS| 70|5931|2 GO RBBP7|IT GO:00345 3421|553 1 -6.31644 M1 1 0 Biological 19 centromere complex assembly -6.31644 6.037113 7.241636 24156 55 873 12 1.37457 0.394068 GB3BP|HJ -3.99912 0 31 1 1 -6.31644 12.57732 08 55|55839| Processes URP|CEN 57082|79 PN|KNL1| 003|9168 MIS12|CE 7|401541 NPL|CEN ADORA2 A|ADORA 2B|AGTR2 135|136|1 |CHRM3| 86|1131|1 CMKLR1| 240|1393| CRHBP|C 1395|181 RHR2|DR 6|1907|19 D5|EDN2| 08|2535|2 EDN3|FZ 840|2846| D2|GPR17 2913|326 |LPAR4|G 9|3357|41 RM3|HRH R-HSA- Reactome 61|4886|5 1 -3.67332 M1 1 0 6 GPCR ligand binding -3.67332 1.955275 4.036497 24156 467 873 33 3.780069 0.645469 1|HTR2B| -1.87888 0 94 1 1 -3.67332 2.548562 500792 Gene Sets 179|5744| MC5R|NP 6387|686 Y1R|PENK 9|6915|78 |PTHLH|C 52|8111|8 XCL12|TA 325|1026 CR1|TBXA 6|10692|5 2R|CXCR4 0865|515 |GPR68|F 54|57486| ZD8|RAM 80326|72 P2|RRH|H 9230 EBP1|ACK R4|NLN| WNT10A| VCAN|GP C4|LUM| 1462|223 OGN|THB 9|4060|49 S1|THBS2 69|7057|7 |ADAMTS 058|9508| 3|ADAMT R-HSA- Reactome 9719|110 1 -3.66655 M1 1 0 6 Diseases of glycosylation -3.66655 2.902458 4.418259 24156 143 873 15 1.718213 0.439813 SL2|KERA| -1.87408 0 33 0 0 -6.2858 7.478406 3781865 Gene Sets 81|11174| ADAMTS 54437|55 6|SEMA5 901|5718 B|THSD1| 8|80731|1 ADAMTS 70692 L3|THSD7 B|ADAMT XIAP|FAS| CASP2|EC 331|355|8 T2|OMG| 35|1894|4 TIAM1|TN 974|7074| FRSF1A|T 7132|874 R-HSA- Reactome NFSF10|RI 1 -3.66655 M1 1 0 6 Death Receptor Signalling -3.66655 2.902458 4.418259 24156 143 873 15 1.718213 0.439813 3|8767|87 -1.87408 0 95 1 1 -3.66655 2.902458 73887 Gene Sets PK2|FAD 72|10276| D|NET1|T 10454|23 AB1|ITGB 421|2608 3BP|ARH 4|50650 GEF26|AR HGEF3 AGTR2|B 186|655|9 MP7|CD3 47|1063|2 4|CENPF| 200|2247| FBN1|FGF 3280|397 2|HES1|LI 6|4089|40 F|SMAD4| 90|4208|5 SMAD5| 125|5156| MEF2C|P 5175|522 CSK5|PD GO GO:00018 8|5420|54 GFRA|PEC 1 -6.29582 M1 1 0 Biological 19 kidney development -6.29582 2.835452 6.014146 24156 283 873 29 3.321879 0.606525 -3.98178 0 10 0 0 -10.1376 3.952872 22 71|5629|6 AM1|PGF| Processes 422|8772| PODXL|P 8854|910 PAT|PRO 4|10413|1 X1|SFRP1| 0736|232 FADD|AL 13|30812| DH1A2|R 80184|11 GN|YAP1| 6039|157 SIX2|SULF 506 1|SOX8|C EP290|OS 1462|406 VCAN|LU 0|4969|10 M|OGN|P Canonical 1 -3.66151 M5882 M1 1 0 11 NABA PROTEOGLYCANS -3.66151 5.534021 5.197698 24156 35 873 7 0.801833 0.301847 216|1108 RG4|KERA -1.871 0 96 1 1 -3.66151 10.37629 Pathways 1|11082|1 |ESM1|HA 45864 PLN3 ACTN2|C AMK2A|C HAT|CHR 88|815|11 NA1|CO 03|1134|1 MT|CREB 312|1385| 1|GABRA 2555|255 2|GABRA 6|2557|28 3|GABRA 90|2902|3 4|GRIA1| 739|3759| GRIN1|KC 3762|383 NA4|KCN 8|4916|55 J2|KCNJ5| R-HSA- Reactome 1 -3.64921 M1 1 0 6 Neuronal System -3.64921 2.024642 4.051911 24156 410 873 30 3.436426 0.616528 63|9312|1 KPNA2|N -1.85968 0 97 1 1 -3.64921 2.294594 112316 Gene Sets 0369|111 TRK3|PRK 41|22843| AA2|KCN 22871|26 B2|CACN 037|2628 G2|IL1RA 0|27133|5 PL1|PPM1 7369|798 E|NLGN1| 61|81027| SIPA1L1|I 81033|34 L1RAPL2| 7730 KCNH5|G JD2|TUBA L3|TUBB1| KCNH6|L ACTL6A|A LDH1A3| PRDM1|B 86|220|63 MP7|CAS 9|655|835 P2|COL5 |1289|129 A1|COL8 5|1545|20 A1|CYP1B 47|2048|2 1|EPHB1| 200|2201| EPHB2|FB 3624|423 N1|FBN2|I 7|4916|51 NHBA|MF 56|5308|5 AP2|NTR GO 629|6498| GO:01500 K3|PDGFR 1 -6.28618 M1 1 0 Biological 19 visual system development -6.28618 2.577489 5.880275 24156 365 873 34 3.894616 0.654786 6935|705 -3.98145 0 7 0 0 -11.4306 6.148912 63 A|PITX2|P Processes 4|8854|11 ROX1|SKI 081|3081 L|ZEB1|T 2|54567|5 H|ALDH1 6890|573 A2|KERA| 81|80184| SOX8|DLL 91851|11 4|MDM1| 6039|157 RHOJ|CEP 506|1706 290|CHR 92|28421 DL1|OSR2 7|341640 |RDH10|A DAMTS18 |LAMA1|F ACTC1|A CTN1|AC 70|87|88| TN2|CDH 1003|100 5|CDH7|C 5|1007|10 DH9|CDH 08|1009|1 10|CDH1 266|2273| 1|CNN3|F 2275|253 HL1|FHL3 5|3672|36 |FZD2|ITG 73|3690|3 A1|ITGA2| 691|4008| ITGB3|ITG 9493|981 B4|LMO7| GO 5|22800|2 KIF23|GIT GO:00059 Cellular 3768|272 2|RRAS2|F 1 -3.63574 M1 1 0 20 adherens junction -3.63574 1.864834 3.969078 24156 549 873 37 4.238259 0.68184 -1.84815 0 32 0 0 -6.28754 6.917526 12 Compone 95|29091| LRT2|PDLI nts 29766|29 M3|STXB 780|5748 P6|TMOD 1|57608|5 3|PARVB| 7619|603 KIAA1210 12|64072| |JCAD|SH 64759|83 ROOM3| 872|8468 AFAP1|C 7|91624|1 DH23|TN 17178|15 S3|HMCN 7285|222 1|PPP1R9 256 B|NEXN|S SX2IP|PR AG1|CDH 639|672|9 PRDM1|B 47|1003|1 RCA1|CD 295|1306| 34|CDH5| 1490|154 COL8A1| 5|1870|20 COL15A1| 47|2048|2 CCN2|CY 247|2277| P1B1|E2F 2324|233 2|EPHB1| 5|3280|36 EPHB2|FG 90|4017|5 F2|VEGFD 156|5175| |FLT4|FN1 5228|558 |HES1|ITG 7|5629|60 B3|LOXL2 GO 95|6422|6 |PDGFRA| GO:00485 1 -6.26594 M1 1 0 Biological 19 blood vessel morphogenesis -6.26594 2.085283 5.60066 24156 690 873 52 5.956472 0.801036 915|7057| PECAM1| -3.96477 0 15 0 0 -9.08083 2.73285 14 Processes 7058|707 PGF|PRK 5|7852|83 D1|PROX 25|9723|1 1|RORA|S 0266|104 FRP1|TBX 13|10516| A2R|THBS 11082|23 1|THBS2| 213|2341 TIE1|CXC 4|28984|5 R4|FZD8| 1129|545 SEMA3E| 67|57381| RAMP2|Y 57608|64 AP1|FBLN 102|7981 5|ESM1|S 2|93649|1 ULF1|ZFP 44455|14 M2|RGCC 332|1062| BIRC5|CE 3832|475 NPE|KIF1 1|5116|64 1|NEK2|P 91|6790|7 CNT|STIL| 272|9493| AURKA|T 10403|10 TK|KIF23| 460|2297 NDC80|T GO GO:00070 4|24137|2 ACC3|TPX 1 -6.25424 M1 1 0 Biological 19 spindle organization -6.25424 3.297473 6.205114 24156 193 873 23 2.634593 0.542066 -3.95623 0 8 0 0 -11.3911 5.158833 51 5886|551 2|KIF4A|P Processes 25|55835| OC1A|CE 57405|79 P192|CEN 441|7986 PJ|SPC25| 6|81027|8 HAUS3|B 3540|126 ORA|TUB 731|2592 B1|NUF2| 66 CCSAP|A ACTN1|A CTN2|CD 87|88|100 H5|CDH7| 3|1005|10 CDH9|CD 07|1008|1 H10|CDH R-HSA- Reactome 009|3691| 1 -3.61479 M1 1 0 6 Cell-Cell communication -3.61479 3.002957 4.416801 24156 129 873 14 1.603666 0.425147 11|ITGB4| -1.83011 0 32 0 0 -6.28754 6.917526 1500931 Gene Sets 3861|390 KRT14|LA 9|3914|50 MA3|LAM 10|29780| B3|CLDN 84612 11|PARVB |PARD6B BMP7|ED N3|FN1|H 655|1908| ES1|HTR2 2335|328 B|SMAD4| 0|3357|40 MEF2C|N GO 89|4208|4 GO:00140 RTN|PITX 1 -6.24937 M1 1 0 Biological 19 neural crest cell differentiation -6.24937 4.716495 6.763104 24156 88 873 15 1.718213 0.439813 902|5308| -3.95449 0 28 0 0 -6.45792 4.716495 33 2|SFRP1|A Processes 6422|885 LDH1A2|S 4|9723|30 EMA3E|S 812|8032 OX8|WNT 6|157506 10A|RDH 10 CREB1|CC 1385|149 N2|EDN2| 0|1907|23 FLT4|HES 24|3280|3 1|LIF|PCS 976|5125| K5|PDGFR 5156|562 A|PROX1| 9|8854|97 ALDH1A2 GO 19|10413| |ADAMTS GO:00303 1 -6.2407 M1 1 0 Biological 19 respiratory tube development -6.2407 3.400795 6.242741 24156 179 873 22 2.520046 0.530463 10454|23 L2|YAP1|T -3.94893 0 34 1 1 -6.2407 4.724164 23 Processes 414|6475 AB1|ZFP 9|91461|9 M2|TNS3| 3649|147 PKDCC|M 372|1575 YOCD|CC 06|28421 BE1|RDH1 7|339829| 0|LAMA1| 340419 CCDC39| RSPO2 ACTL6A|A LDH1A3| PRDM1|B 86|220|63 MP7|CAS 9|655|835 P2|COL5 |1289|129 A1|COL8 5|1545|20 A1|CYP1B 47|2048|2 1|EPHB1| 200|2201| EPHB2|FB 3624|423 N1|FBN2|I 7|4916|51 NHBA|MF 56|5308|5 AP2|NTR GO 629|6498| GO:00488 K3|PDGFR 1 -6.15026 M1 1 0 Biological 19 sensory system development -6.15026 2.542658 5.790299 24156 370 873 34 3.894616 0.654786 6935|705 -3.86466 0 7 0 0 -11.4306 6.148912 80 A|PITX2|P Processes 4|8854|11 ROX1|SKI 081|3081 L|ZEB1|T 2|54567|5 H|ALDH1 6890|573 A2|KERA| 81|80184| SOX8|DLL 91851|11 4|MDM1| 6039|157 RHOJ|CEP 506|1706 290|CHR 92|28421 DL1|OSR2 7|341640 |RDH10|A DAMTS18 |LAMA1|F EPHB2|FZ 2048|253 D2|INHB 5|3624|36 A|IRF6|S 64|4089|4 MAD4|M 208|5156| EF2C|PDG GO GO:00600 9242|924 FRA|MSC| 1 -6.1192 M1 1 0 Biological 19 roof of mouth development -6.1192 4.611684 6.646916 24156 90 873 15 1.718213 0.439813 -3.83967 0 35 1 1 -6.1192 4.611684 21 9|51141|5 DHRS3|IN Processes 5003|914 SIG2|PAK 61|11603 1IP1|PKD 9|117166| CC|OSR2| 124857 WFIKKN1| WFIKKN2 BRCA1|C 672|899|3 CNF|KIF1 832|4751| 1|NEK2|S 6491|679 GO TIL|AURK GO:00466 0|10733|2 1 -6.05162 M1 1 0 Biological 19 regulation of centrosome cycle -6.05162 5.724849 6.975938 24156 58 873 12 1.37457 0.394068 A|PLK4|P -3.78399 0 19 0 0 -7.81934 13.83505 05 5886|558 Processes OC1A|CE 35|56890| NPJ|MDM 79648|85 1|MCPH1| 459 CEP295 GO 2902|849 GRIN1|PR GO:00430 Cellular 2|22871|1 SS12|NLG 1 -3.58101 M1 1 0 20 synaptic cleft -3.58101 8.138266 5.700969 24156 17 873 5 0.572738 0.255402 -1.80209 0 99 1 1 -3.58101 8.138266 83 Compone 33584|22 N1|EGFLA nts 2256 M|CDHR3 BUB1|BU 699|701|1 B1B|CENP 062|1063| E|CENPF| 7153|727 TOP2A|TT 2|9232|93 GO K|PTTG1| GO:00513 19|9787|1 1 -5.99285 M1 1 0 Biological 19 chromosome separation -5.99285 4.51143 6.534091 24156 92 873 15 1.718213 0.439813 TRIP13|D -3.73228 0 25 0 0 -7.23866 13.83505 04 0403|104 Processes LGAP5|N 60|23397| DC80|TA 56155|80 CC3|NCA 010|1469 PH|TEX14 56 |RMI1|EM ACTC1|A CTN1|AC TN2|ADO 70|87|88| RA2A|AD 135|136|1 ORA2B|C 008|1009| DH10|CD 1131|204 H11|CHR 7|2048|22 M3|EPHB 39|2890|2 1|EPHB2| GO 902|2913| GPC4|GRI GO:00989 Cellular 3690|383 A1|GRIN1 1 -3.56939 M1 1 0 20 glutamatergic synapse -3.56939 2.092697 4.027593 24156 357 873 27 3.092784 0.58593 -1.79327 0 58 0 0 -4.67369 3.739203 78 Compone 8|4885|49 |GRM3|IT nts 16|6456|7 GB3|KPN 074|1036 A2|NPTX2 9|11141|1 |NTRK3|S 1346|228 H3GL2|TI 71|23237| AM1|CAC 26280|34 NG2|IL1R 7730 APL1|SYN PO|NLGN 1|ARC|IL1 RAPL2|LR PRDM1|F 639|2307| OXS1|HIC 3090|328 1|HES1|S 0|4090|56 MAD5|PR 29|6498|6 OX1|SKIL| 935|6936| ZEB1|GCF 7022|909 GO C2|TFAP2 GO:00012 DNA-binding transcription repressor 6|9242|10 1 -3.56935 M1 1 0 Molecular 21 -3.56935 2.352519 4.13716 24156 247 873 21 2.405498 0.518571 C|TBX18| -1.79327 0 82 0 0 -3.95806 2.352519 27 activity, RNA polymerase II-specific 732|2359 Functions MSC|TCF 8|27022|5 L5|PATZ1| 5237|555 FOXD3|V 02|14445 RTN|HES6 5|148979| |E2F7|GLI 153572|4 S1|IRX2|Z 03341 BTB34 BARD1|B 580|672|6 Resolution of D-loop Structures through RCA1|BR R-HSA- Reactome 75|4361|9 1 -3.56689 M1 1 0 6 Synthesis-Dependent Strand Annealing -3.56689 6.385408 5.320076 24156 26 873 6 0.687285 0.279617 CA2|MRE -1.79175 0 70 0 0 -4.32747 27.6701 5693554 Gene Sets 156|8001 (SDSA) 11|EXO1| 0 RMI1 ACTL6A|P RDM1|CD K1|CENPF 86|639|98 |CKS2|DN 3|1063|11 MT3B|ER 64|1789|2 G|FLI1|H2 078|2313| AZ1|SMA 3015|408 D4|MEF2 9|4208|42 C|MEOX1 22|4772|4 |NFATC1| 998|5563| ORC1|PR 6498|693 KAA2|SKI 5|7153|72 L|ZEB1|T GO 70|8208|8 OP2A|TTF GO:00036 1 -3.5444 M1 1 0 Molecular 21 chromatin binding -3.5444 1.844674 3.898175 24156 555 873 37 4.238259 0.68184 318|8726| 1|CHAF1B -1.77021 0 100 1 1 -3.5444 1.844674 82 Functions 9156|932 |CDC45|E 4|9866|10 ED|EXO1| 360|1041 HMGN3|T 3|10891|2 RIM66|NP 3397|235 M3|YAP1| 98|29128| PPARGC1 55506|57 A|NCAPH 616|6464 |PATZ1|U 1|79366|9 HRF1|MA 1442|254 CROH2A 394 2|TSHZ3| EBF2|HM GN5|FAA P24|MCM BRCA1|B UB1|BUB1 672|699|7 B|CENPE| 01|1062|1 CENPF|D 063|1789| NMT3B|LI 3976|408 F|SMAD4| 9|4288|43 MKI67|M 61|4751|5 RE11|NEK 073|5081| 2|PARN|P 5587|715 AX7|PRK 3|7272|75 D1|TOP2 GO GO:00330 20|8318|8 A|TTK|XR 1 -5.99119 M1 1 0 Biological 19 regulation of chromosome organization -5.99119 2.543491 5.70534 24156 359 873 33 3.780069 0.645469 -3.73228 0 38 1 1 -5.99119 2.543491 44 726|9232| CC5|CDC Processes 9319|978 45|EED|PT 7|10403|1 TG1|TRIP 0460|108 13|DLGAP 91|54464| 5|NDC80| 55183|55 TACC3|PP 196|5615 ARGC1A| 5|79648|8 XRN1|RIF 0119|801 1|RESF1|T 69|93649 EX14|MC PH1|PIF1| CTC1|MY ACTC1|A CTN2|CN 70|88|126 N3|CCN2| 6|1490|18 ECT2|SM 94|4089|4 AD4|MEF 208|4233| 2C|MET|P 5156|562 DGFRA|P 9|6422|71 GO ROX1|SFR GO:00310 39|7140|9 1 -5.94247 M1 1 0 Biological 19 actomyosin structure organization -5.94247 3.166231 5.97167 24156 201 873 23 2.634593 0.542066 P1|TNNT -3.69491 0 14 0 0 -9.68163 3.166231 32 493|1032 Processes 2|TNNT3| 4|10529|2 KIF23|KLH 2843|229 L41|NEBL| 98|27063| PPM1E|LI 28984|29 MCH1|A 766|5444 NKRD1|R 3|84952 GCC|TM OD3|ANL GO 2200|220 FBN1|FBN GO:00015 Cellular 1 -3.52458 M1 1 0 20 microfibril -3.52458 11.06804 6.166143 24156 10 873 4 0.45819 0.22857 1|4052|42 2|LTBP1| -1.756 0 24 0 0 -7.35548 20.75258 27 Compone 37 MFAP2 nts GO 2199|220 FBLN2|FB GO:00300 extracellular matrix constituent conferring 1 -3.52458 M1 1 0 Molecular 21 -3.52458 11.06804 6.166143 24156 10 873 4 0.45819 0.22857 0|2201|10 N1|FBN2| -1.756 0 24 0 0 -7.35548 20.75258 23 elasticity Functions 516 FBLN5 ALDH1A3 220|1385| |CREB1|C 1490|190 CN2|EDN 7|2324|32 2|FLT4|HE 80|3976|5 S1|LIF|PD 156|5629| GFRA|PR 8854|924 OX1|ALD 2|9719|10 GO H1A2|MS GO:00605 413|1045 1 -5.94247 M1 1 0 Biological 19 respiratory system development -5.94247 3.166231 5.97167 24156 201 873 23 2.634593 0.542066 C|ADAMT -3.69491 0 34 0 0 -6.2407 4.724164 41 4|23414|6 Processes SL2|YAP1| 4759|914 TAB1|ZFP 61|93649| M2|TNS3| 147372|1 PKDCC|M 57506|28 YOCD|CC 4217|339 BE1|RDH1 829|3404 0|LAMA1| 19 CCDC39| ACTN1|A CTN2|CD 87|88|100 H5|CDH7| 3|1005|10 CDH9|CD 07|1008|1 H10|CDH 009|1894| 11|ECT2|F 2335|282 N1|GPM6 4|3673|36 B|ITGA2|I 91|3861|3 TGB4|KRT GO GO:00343 909|3914| 14|LAMA 1 -5.93077 M1 1 0 Biological 19 cell junction assembly -5.93077 2.912642 5.850497 24156 247 873 26 2.978236 0.575317 -3.69153 0 39 1 1 -5.93077 3.633448 29 5010|517 3|LAMB3| Processes 5|5795|64 CLDN11| 22|7057|1 PECAM1| 0266|229 PTPRJ|SF 98|64072| RP1|THBS 84612|22 1|RAMP2| 2256|100 LIMCH1|C 506658 DH23|PA RD6B|CD HR3|OCL 4175|499 MCM6|O 8|4999|83 RC1|ORC R-HSA- Reactome Activation of ATR in response to replication 1 -3.5038 M1 1 0 6 -3.5038 5.234884 4.991763 24156 37 873 7 0.801833 0.301847 17|8318|5 2|CDC7|C -1.738 0 20 0 0 -7.69554 7.546392 176187 Gene Sets stress 5388|639 DC45|MC 67 M10|CLSP ALK|ASPA |BMP7|CR 238|443|6 ABP2|DA 55|1382|1 B1|DNMT 600|1789| 3B|ECT2|E 1894|204 PHB2|FN1 8|2335|28 |GOLGA4| 03|3280|3 HES1|ITP 706|3976| KA|LIF|ME 4208|491 F2C|NTRK 6|5121|52 3|PCP4|SE 70|5587|5 RPINE2|P 629|6387| RKD1|PR GO 6498|669 OX1|CXC GO:00507 1 -5.92684 M1 1 0 Biological 19 positive regulation of neurogenesis -5.92684 2.286785 5.537357 24156 484 873 40 4.581901 0.707671 2|6935|70 L12|SKIL|S -3.69034 0 29 0 0 -6.42481 3.074456 69 Processes 74|7133|7 PINT1|ZE 520|7852| B1|TIAM1 9423|958 |TNFRSF1 5|11141|2 B|XRCC5| 2871|270 CXCR4|N 63|30812| TN1|KIF2 57165|15 0B|IL1RA 1835|259 PL1|NLG 266|2850 N1|ANKR 16|33947 D1|SOX8| 9|375567| GJC2|CPN 729230 E9|ASPM| ALKAL2|B RINP3|V 1003|423 CDH5|ME 3|9928|11 T|KIF14|KI 004|2297 F2C|TPX2| 4|26586|5 CKAP2|N 4820|551 DE1|CEP1 GO 25|55835| 92|CENPJ| GO:00311 microtubule polymerization or 1 -5.92255 M1 1 0 Biological 19 -5.92255 3.986371 6.296899 24156 118 873 17 1.947308 0.467671 57159|81 TRIM54|K -3.68877 0 40 1 1 -5.92255 5.29853 09 depolymerization Processes 930|1267 IF18A|CC 31|22115 SAP|SKA3 0|246176| |GAS2L2| 344148|3 NCKAP5| 47240|10 KIF24|OC 0506658 LN BMP7|BU 655|699|7 B1|BUB1B 01|1063|3 |CENPF|LI GO 976|7272| GO:00517 F|TTK|PTT 1 -5.88477 M1 1 0 Biological 19 negative regulation of nuclear division -5.88477 5.534021 6.808913 24156 60 873 12 1.37457 0.394068 9232|931 -3.65371 0 25 0 0 -7.23866 13.83505 84 G1|TRIP1 Processes 9|10403|2 3|NDC80| 7085|289 MTBP|RG 84|56155 CC|TEX14 CDH10|C 1008|113 HRM3|CH 1|1134|25 RNA1|GA GO 56|2557|2 BRA3|GA GO:00990 Cellular integral component of postsynaptic 1 -3.49548 M1 1 0 20 -3.49548 3.739203 4.569672 24156 74 873 10 1.145475 0.360151 890|2902| BRA4|GRI -1.7317 0 58 0 0 -4.67369 3.739203 60 Compone specialization membrane 10369|22 A1|GRIN1 nts 871|3477 |CACNG2| 30 NLGN1|L RRTM1 BIRC5|CD 332|983|1 K1|CENPE 062|1063| |CENPF|E 1894|475 CT2|NEK2 1|6790|94 GO |AURKA|K 93|9585|9 GO:00304 Cellular IF23|KIF2 1 -3.49473 M1 1 0 20 midbody -3.49473 2.598849 4.180794 24156 181 873 17 1.947308 0.467671 928|1110 -1.7317 0 102 1 1 -3.49473 18.44674 96 Compone 0B|KIF14| 4|24137|5 nts KATNA1| 4443|551 KIF4A|AN 65|56155| LN|CEP55 79720|25 |TEX14|VP 9266 S37B|ASP COL7A1|F 1294|220 BN1|FLI1| 0|2313|40 SMAD5| 90|4208|5 MEF2C|PI 308|8111| TX2|GPR6 9104|924 8|RGN|D 9|23213|2 HRS3|SUL 5886|511 F1|POC1 GO 41|51715| GO:00603 A|INSIG2| 1 -5.83362 M1 1 0 Biological 19 bone development -5.83362 3.03234 5.850254 24156 219 873 24 2.749141 0.553399 55790|56 -3.61057 0 11 0 0 -10.1305 3.03234 48 RAB23|CS Processes 034|7964 GALNACT 8|80169|8 1|PDGFC| 0263|116 MCPH1|C 039|1583 TC1|TRIM 26|19652 45|OSR2| 7|202151| FREM1|A 359845|6 NO6|RAN 42658 BP3L|RFL CREB1|CC 1385|149 N2|EDN2| 0|1907|23 FLT4|HES 24|3280|3 1|LIF|PDG 976|5156| FRA|PRO 5629|885 X1|ALDH 4|9719|10 1A2|ADA GO 413|1045 GO:00303 MTSL2|YA 1 -5.81553 M1 1 0 Biological 19 lung development -5.81553 3.320412 5.96543 24156 175 873 21 2.405498 0.518571 4|23414|6 -3.59512 0 34 0 0 -6.2407 4.724164 24 P1|TAB1| Processes 4759|914 ZFPM2|T 61|93649| NS3|PKD 147372|1 CC|MYOC 57506|28 D|CCBE1| 4217|339 RDH10|L 829|3404 AMA1|CC 19 DC39|RSP 655|1003| BMP7|CD 1240|190 H5|CMKL 7|1908|22 R1|EDN2| 47|2277|2 EDN3|FG 324|2335| F2|VEGFD 3673|369 |FLT4|FN1 0|3958|42 |ITGA2|IT 33|4916|5 GB3|LGAL 156|5175| S3|MET|N 5228|542 TRK3|PD 0|5587|56 GFRA|PEC 29|6387|6 AM1|PGF| 869|7057| PODXL|P GO 7074|713 RKD1|PR GO:20001 1 -5.75682 M1 1 0 Biological 19 positive regulation of cell motility -5.75682 2.132114 5.362775 24156 584 873 45 5.154639 0.748342 0|7852|87 OX1|CXC -3.54164 0 42 1 1 -5.75682 3.654542 47 Processes 72|9423|9 L12|TACR 547|9585| 1|THBS1| 9723|106 TIAM1|TN 31|22800| FAIP6|CX 51512|56 CR4|FAD 034|5738 D|NTN1|C 1|57608|5 XCL14|KIF 8494|647 20B|SEM 50|83483| A3E|POST 117581|1 N|RRAS2| 31578|14 GTSE1|PD 7372|196 GFC|RHO 527|7292 J|JCAD|JA 30 M2|SMUR BUB1|BU GO 699|701|6 B1B|AURK GO:00007 Cellular condensed nuclear chromosome, 790|1040 1 -3.47114 M1 1 0 20 -3.47114 6.148912 5.183449 24156 27 873 6 0.687285 0.279617 A|NDC80| -1.71176 0 25 0 0 -7.23866 13.83505 80 Compone centromeric region 3|79003|8 MIS12|N nts 3540 UF2 1062|189 CENPE|EC 4|4751|10 T2|NEK2| GO GO:00086 attachment of spindle microtubules to 403|1100 NDC80|KI 1 -5.74913 M1 1 0 Biological 19 -5.74913 7.546392 7.28676 24156 33 873 9 1.030928 0.341867 -3.53655 0 2 0 0 -22.074 10.54099 08 kinetochore 4|56155|5 F2C|TEX1 Processes 7082|790 4|KNL1|M 03|83540 IS12|NUF CCND2|C 894|899|9 CNF|CCN GO 01|1030|1 G2|CDKN GO:00165 cyclin-dependent protein serine/threonine 1 -3.46684 M1 1 0 Molecular 21 -3.46684 4.517568 4.772656 24156 49 873 8 0.91638 0.322501 164|9133| 2B|CKS2| -1.70928 0 37 0 0 -6.01116 5.929308 38 kinase regulator activity Functions 9134|854 CCNB2|C 17 CNE2|CC NB3 CENPI|H2 2491|301 AZ1|PRIM 5|5558|59 2|RBBP7|I 31|23421| TGB3BP| 55355|55 R-HSA- Reactome HJURP|CE 1 -3.46175 M1 1 0 6 Chromosome Maintenance -3.46175 3.048401 4.319147 24156 118 873 13 1.489118 0.40992 839|5708 -1.70509 0 31 0 0 -6.31644 12.57732 73886 Gene Sets NPN|KNL 2|79075|8 1|DSCC1| 0119|801 PIF1|CTC 69|91687| 1|CENPL| 401541 CENPP ADORA2 A|CDH9|C 135|1007| DH10|CH 1008|113 RM3|CHR 1|1134|20 NA1|EPH GO 48|2239|2 B2|GPC4| GO:00992 Cellular 556|2557| GABRA3| 1 -3.44913 M1 1 0 20 intrinsic component of synaptic membrane -3.44913 2.666998 4.173161 24156 166 873 16 1.832761 0.453972 -1.69338 0 58 0 0 -4.67369 3.739203 40 Compone 2890|290 GABRA4| nts 2|2913|49 GRIA1|GR 16|10369| IN1|GRM 22871|34 3|NTRK3| 7730 CACNG2| NLGN1|L RRTM1 COL4A5| COL4A6| 1287|128 COL5A1| 8|1289|12 COL7A1| Canonical 94|1295|1 1 -3.44741 M160 M1 1 0 11 PID AVB3 INTEGRIN PATHWAY -3.44741 3.689347 4.516806 24156 75 873 10 1.145475 0.360151 COL8A1| -1.69256 0 5 0 0 -15.2617 12.29782 Pathways 299|1306| COL9A3| 2247|233 COL15A1| 5|3690 FGF2|FN1 |ITGB3 AHR|ALK| CHRNA1| EPHB1|EP 196|238|1 HB2|FLT4| 134|2047| GABRA2| 2048|232 GABRA3| 4|2555|25 GABRA4| 56|2557|2 GABRG1| 565|2890| GRIA1|GR 2902|367 IN1|ITGA 2|3673|36 1|ITGA2|I 90|3691|4 TGB3|ITG GO 233|4916| B4|MET|N GO:00432 Cellular 5156|707 TRK3|PD 1 -3.44568 M1 1 0 20 receptor complex -3.44568 1.858836 3.837448 24156 521 873 35 4.009164 0.663949 -1.69254 0 69 0 0 -4.35611 3.891108 35 Compone 5|7132|71 GFRA|TIE nts 33|9180|9 1|TNFRSF 865|1026 1A|TNFRS 6|10369|2 F1B|OSM 2871|269 R|TRIL|RA 96|51284| MP2|CAC 51559|13 NG2|NLG 1450|165 N1|GPR1 829|2846 60|TLR7| 56|37556 NT5DC3| 7|389400 CD200R1| GPR156|E PHA10|V WC2|GFR ACTN1|A CTN2|CD 87|88|947 34|CDK6| |1021|129 COL8A1| 5|1490|20 CCN2|EP 47|2199|2 HB1|FBLN 335|2824| 2|FN1|GP 3672|367 M6B|ITGA 3|3690|36 1|ITGA2|I 91|3914|5 TGB3|ITG 175|5795| B4|LAMB GO GO:00315 6422|705 3|PECAM 1 -5.69907 M1 1 0 Biological 19 cell-substrate adhesion -5.69907 2.508338 5.527915 24156 353 873 32 3.665521 0.635992 -3.49254 0 39 0 0 -5.93077 3.633448 89 7|7074|97 1|PTPRJ|S Processes 23|9928|1 FRP1|THB 0516|106 S1|TIAM1 31|22998| |SEMA3E| 25975|29 KIF14|FBL 780|1335 N5|POST 84|13622 N|LIMCH 7|151887| 1|EGFL6|P 158326|3 ARVB|EGF 75567 LAM|COL 26A1|CC DC80|FRE BMP7|BU 655|699|7 B1|BUB1B 01|1063|7 |CENPF|T GO 272|9232| GO:00458 negative regulation of mitotic nuclear TK|PTTG1 1 -5.69743 M1 1 0 Biological 19 -5.69743 5.853291 6.783981 24156 52 873 11 1.260023 0.37751 9319|104 -3.49254 0 25 0 0 -7.23866 13.83505 39 division |TRIP13|N Processes 03|27085| DC80|MT 28984|56 BP|RGCC| 155 TEX14 ACTC1|A CTN2|AG 70|88|186 TR2|BMP |655|983| 7|CDK1|C 1063|113 ENPF|CH 4|1385|20 RNA1|CR 47|2247|4 EB1|EPHB 089|4208| 1|FGF2|S 5081|515 MAD4|M 6|5600|56 EF2C|PAX 29|6445|7 7|PDGFR GO 093|7135| A|MAPK1 GO:00147 1 -5.63533 M1 1 0 Biological 19 striated muscle tissue development -5.63533 2.412265 5.444547 24156 390 873 34 3.894616 0.654786 7139|885 1|PROX1| -3.43548 0 13 0 0 -9.83559 6.28866 06 Processes 4|9242|10 SGCG|TLL 324|1041 2|TNNI1|T 3|10529|2 NNT2|AL 3414|270 DH1A2|M 63|30812| SC|KLHL4 54567|57 1|YAP1|N 486|5753 EBL|ZFPM 8|64091|9 2|ANKRD 3649|642 1|SOX8|D 658 LL4|NLN| ALPK3|PO PDC2|MY CAMK2A| CASP2|C 815|835|8 CND2|CD 94|983|10 K1|CDK6| 21|1030|2 CDKN2B| 103|2273| ESRRB|FH 3624|417 L1|INHBA 5|4998|49 |MCM6|O 99|5471|5 RC1|ORC 558|6241| GO 2|PPAT|P GO:00448 6790|702 1 -5.63223 M1 1 0 Biological 19 cell cycle G1/S phase transition -5.63223 2.630928 5.550378 24156 305 873 29 3.321879 0.606525 RIM2|RR -3.43488 0 30 0 0 -6.32789 4.035223 43 9|7465|83 Processes M2|AURK 17|8318|9 A|TFDP2| 134|9928| WEE1|CD 27085|28 C7|CDC4 984|5151 5|CCNE2| 2|55388|5 KIF14|MT 7165|131 BP|RGCC| 405|1444 GTSE1|M 55 CM10|GJ C2|TRIM7 70|87|88| ACTC1|A 1266|149 CTN1|AC 0|1894|22 TN2|CNN 75|2824|3 3|CCN2|E 706|3759| CT2|FHL3| 3762|408 GPM6B|IT 9|4208|42 PKA|KCNJ 33|4632|4 2|KCNJ5|S 916|5156| MAD4|M 5629|638 EF2C|MET 7|6422|71 |MYL1|NT 35|7136|7 RK3|PDGF 139|7140| RA|PROX GO 7456|949 1|CXCL12 GO:00300 1 -5.61316 M1 1 0 Biological 19 actin filament-based process -5.61316 1.93867 5.177262 24156 785 873 55 6.300115 0.822312 3|9645|97 |SFRP1|T -3.4183 0 14 0 0 -9.68163 3.166231 29 Processes 23|9938|1 NNI1|TN 0324|105 NI2|TNNT 29|10788| 2|TNNT3| 11346|22 WIPF1|KIF 843|2299 23|MICAL 8|23433|2 2|SEMA3 6037|270 E|ARHGA 63|27295| P25|KLHL 28984|29 41|NEBL|I 766|2978 QGAP2|S 0|50853|5 YNPO|PP 4443|557 M1E|LIM 85|57381| CH1|RHO 57619|80 Q|SIPA1L ACTC1|A CTN2|AG 70|88|186 TR2|BMP |655|983| 7|CDK1|C 1063|113 ENPF|CH 4|1385|20 RNA1|CR 47|2247|4 EB1|EPHB 089|4208| 1|FGF2|S 5081|515 MAD4|M 6|5600|56 EF2C|PAX 29|6445|7 7|PDGFR 093|7135| A|MAPK1 GO GO:00605 7139|885 1|PROX1| 1 -5.59988 M1 1 0 Biological 19 muscle tissue development -5.59988 2.367857 5.402431 24156 409 873 35 4.009164 0.663949 -3.4075 0 13 0 0 -9.83559 6.28866 37 4|9242|10 SGCG|TLL Processes 324|1041 2|TNNI1|T 3|10529|1 NNT2|AL 0891|234 DH1A2|M 14|27063| SC|KLHL4 30812|54 1|YAP1|N 567|5748 EBL|PPAR 6|57538|6 GC1A|ZFP 4091|936 M2|ANKR 49|64265 D1|SOX8| 8 DLL4|NLN |ALPK3|P OPDC2|M 655|1003| BMP7|CD 1240|190 H5|CMKL 7|1908|22 R1|EDN2| 47|2277|2 EDN3|FG 324|2335| F2|VEGFD 3673|369 |FLT4|FN1 0|3958|42 |ITGA2|IT 33|4916|5 GB3|LGAL 156|5175| S3|MET|N 5228|542 TRK3|PD 0|5587|56 GFRA|PEC 29|6387|6 AM1|PGF| 869|7057| PODXL|P GO 7074|713 RKD1|PR GO:00400 1 -5.58005 M1 1 0 Biological 19 positive regulation of locomotion -5.58005 2.079779 5.23916 24156 612 873 46 5.269187 0.756154 0|7852|87 OX1|CXC -3.39013 0 42 0 0 -5.75682 3.654542 17 Processes 72|9423|9 L12|TACR 547|9585| 1|THBS1| 9723|106 TIAM1|TN 31|22800| FAIP6|CX 51512|56 CR4|FAD 034|5738 D|NTN1|C 1|57608|5 XCL14|KIF 8494|647 20B|SEM 50|79720| A3E|POST 83483|11 N|RRAS2| 7581|131 GTSE1|PD 578|1473 GFC|RHO 72|19652 J|JCAD|JA 7|729230 M2|SMUR 672|947|1 BRCA1|C 003|1295| D34|CDH 1306|149 5|COL8A1 0|1545|18 |COL15A1 70|2047|2 |CCN2|CY 048|2247| P1B1|E2F 2277|232 2|EPHB1| 4|2335|36 EPHB2|FG 90|4017|5 F2|VEGFD 156|5175| |FLT4|FN1 5228|558 |ITGB3|LO 7|6095|64 XL2|PDGF 22|6915|7 RA|PECA GO 057|7058| M1|PGF|P GO:00015 1 -5.56143 M1 1 0 Biological 19 angiogenesis -5.56143 2.09622 5.238127 24156 594 873 45 5.154639 0.748342 7075|785 RKD1|RO -3.37881 0 15 0 0 -9.08083 2.73285 25 Processes 2|8325|97 RA|SFRP1 23|10266| |TBXA2R| 10516|11 THBS1|TH 082|2321 BS2|TIE1| 3|28984|5 CXCR4|FZ 1129|545 D8|SEMA 67|57381| 3E|RAMP 57608|64 2|FBLN5|E 102|7981 SM1|SULF 2|144455| 1|RGCC|A 147372|4 NGPTL4| 41478|64 DLL4|RH 1700|729 OJ|JCAD| 230 TNMD|M 983|4751| CDK1|NE 5116|865 K2|PCNT| 5|9662|98 DYNLL1|C 14|10733| EP135|SFI 51098|54 1|PLK4|IF 820|5511 T52|NDE1 R-HSA- Reactome 1 -3.41191 M1 1 0 6 Cilium Assembly -3.41191 2.47792 4.074196 24156 201 873 18 2.061856 0.480948 2|55125|5 |WDR60| -1.66624 0 12 0 0 -10.0997 6.06468 5617833 Gene Sets 5835|794 CEP192|C 41|79861| ENPJ|HA 80184|81 US3|TUB 027|1214 AL3|CEP2 41|34724 90|TUBB1 0 |NEDD1|K ACTN2|C 88|815|12 AMK2A|C 66|1312|2 NN3|CO 890|2902| MT|GRIA1 2913|370 |GRIN1|G GO 6|3739|37 RM3|ITPK GO:00431 Cellular 1 -3.41128 M1 1 0 20 dendritic spine -3.41128 2.556477 4.103842 24156 184 873 17 1.947308 0.467671 59|7074|1 A|KCNA4| -1.66624 0 107 1 1 -3.41128 3.074456 97 Compone 1346|228 KCNJ2|TI nts 71|23237| AM1|SYN 26037|57 PO|NLGN 537|8468 1|ARC|SIP 7 A1L1|SOR CS2|PPP1 70|87|88| ACTC1|A 1266|149 CTN1|AC 0|1894|22 TN2|CNN 75|2824|3 3|CCN2|E 706|4089| CT2|FHL3| 4208|423 GPM6B|IT 3|4916|51 PKA|SMA 56|5629|6 D4|MEF2 387|6422| C|MET|NT 7139|714 RK3|PDGF 0|7456|94 RA|PROX 93|9645|9 1|CXCL12 723|9938| |SFRP1|T GO 10324|10 NNT2|TN GO:00300 1 -5.52468 M1 1 0 Biological 19 actin cytoskeleton organization -5.52468 1.999285 5.16455 24156 692 873 50 5.727377 0.786436 529|1078 NT3|WIPF -3.35396 0 14 0 0 -9.68163 3.166231 36 Processes 8|11346|2 1|KIF23|M 2843|229 ICAL2|SE 98|23433| MA3E|AR 26037|27 HGAP25| 063|2729 KLHL41|N 5|28984|2 EBL|IQGA 9766|297 P2|SYNP 80|50853| O|PPM1E| 54443|55 LIMCH1|R 785|5738 HOQ|SIP 1|57619|8 A1L1|ANK 0731|817 RD1|PDLI 88|84687| M3|RGCC 84940|84 |TMOD3| ACTN2|C 88|1393|2 RHBP|EP 048|2890| HB2|GRIA GO GO:20003 2902|420 1|GRIN1| 1 -5.5147 M1 1 0 Biological 19 regulation of NMDA receptor activity -5.5147 7.115169 7.010291 24156 35 873 9 1.030928 0.341867 -3.34632 0 45 1 1 -5.5147 9.223368 10 8|10891|2 MEF2C|P Processes 2871|729 PARGC1A 230 |NLGN1|C CR2 ACTC1|A CTN1|AC 70|87|88| TN2|CDH 1003|100 5|CDH7|C 5|1007|10 DH9|CDH 08|1009|1 10|CDH1 266|2273| 1|CNN3|F 2275|253 HL1|FHL3 5|3672|36 |FZD2|ITG 73|3690|3 A1|ITGA2| 691|4008| ITGB3|ITG 9493|981 B4|LMO7| GO 5|22800|2 KIF23|GIT GO:00701 Cellular 3768|272 2|RRAS2|F 1 -3.39657 M1 1 0 20 anchoring junction -3.39657 1.812024 3.781911 24156 565 873 37 4.238259 0.68184 -1.65416 0 32 0 0 -6.28754 6.917526 61 Compone 95|29091| LRT2|PDLI nts 29766|29 M3|STXB 780|5748 P6|TMOD 1|57608|5 3|PARVB| 7619|603 KIAA1210 12|64072| |JCAD|SH 64759|83 ROOM3| 872|8468 AFAP1|C 7|91624|1 DH23|TN 17178|15 S3|HMCN 7285|222 1|PPP1R9 256 B|NEXN|S SX2IP|PR AG1|CDH BARD1|B 580|672|9 RCA1|CD 83|4175|4 K1|MCM6 361|4998| |MRE11|O 4999|746 RC1|ORC R-HSA- Reactome 5|8317|83 1 -3.39089 M1 1 0 6 G2/M Checkpoints -3.39089 2.635248 4.118437 24156 168 873 16 1.832761 0.453972 2|WEE1|C -1.65023 0 20 0 0 -7.69554 7.546392 69481 Gene Sets 18|9133|9 DC7|CDC 156|5151 45|CCNB 2|55388|6 2|EXO1|G 3967|800 TSE1|MC 10 M10|CLSP BMP7|CD 655|1003| H5|CMKL 1240|190 R1|EDN2| 7|1908|22 EDN3|FG 47|2277|2 F2|VEGFD 324|2335| |FLT4|FN1 3673|369 |ITGA2|IT 0|3958|42 GB3|LGAL 33|4916|5 S3|MET|N 156|5175| TRK3|PD 5228|542 GFRA|PEC 0|5587|56 AM1|PGF| 29|6387|7 PODXL|P 057|7074| GO RKD1|PR GO:00303 7130|785 1 -5.48911 M1 1 0 Biological 19 positive regulation of cell migration -5.48911 2.124669 5.214235 24156 560 873 43 4.925544 0.732406 OX1|CXC -3.32537 0 42 0 0 -5.75682 3.654542 35 2|8772|95 Processes L12|THBS 47|9585|9 1|TIAM1| 723|1063 TNFAIP6| 1|22800|5 CXCR4|FA 1512|560 DD|CXCL 34|57381| 14|KIF20B 57608|58 |SEMA3E| 494|6475 POSTN|R 0|83483|1 RAS2|GTS 17581|13 E1|PDGFC 1578|147 |RHOJ|JC 372|1965 AD|JAM2| 27|72923 SMURF2| 0 PLVAP|T ACTC1|B MP7|COL 70|655|12 5A1|FZD2 89|2535|3 |HES1|HT 280|3357| R2B|SMA 4089|420 D4|MEF2 8|4886|53 C|NPY1R| 08|5629|6 PITX2|PR 491|7054| GO OX1|STIL| GO:00030 7135|713 1 -5.48317 M1 1 0 Biological 19 heart morphogenesis -5.48317 2.756409 5.524379 24156 261 873 26 2.978236 0.575317 TH|TNNI1 -3.3224 0 13 0 0 -9.83559 6.28866 07 9|8854|92 Processes |TNNT2|A 49|9645|1 LDH1A2| 0413|104 DHRS3|M 54|23414| ICAL2|YA 23768|27 P1|TAB1| 063|5109 ZFPM2|FL 8|54567|3 RT2|ANK 39829 RD1|IFT5 2|DLL4|C 655|1003| BMP7|CD 1240|190 H5|CMKL 7|1908|22 R1|EDN2| 47|2277|2 EDN3|FG 324|2335| F2|VEGFD 3673|369 |FLT4|FN1 0|3958|42 |ITGA2|IT 33|4916|5 GB3|LGAL 156|5175| S3|MET|N 5228|542 TRK3|PD 0|5587|56 GFRA|PEC 29|6387|6 AM1|PGF| 869|7057| PODXL|P GO 7074|713 RKD1|PR GO:00512 positive regulation of cellular component 1 -5.42823 M1 1 0 Biological 19 -5.42823 2.071805 5.152316 24156 601 873 45 5.154639 0.748342 0|7852|87 OX1|CXC -3.2759 0 42 0 0 -5.75682 3.654542 72 movement Processes 72|9423|9 L12|TACR 547|9585| 1|THBS1| 9723|106 TIAM1|TN 31|22800| FAIP6|CX 51512|56 CR4|FAD 034|5738 D|NTN1|C 1|57608|5 XCL14|KIF 8494|647 20B|SEM 50|83483| A3E|POST 117581|1 N|RRAS2| 31578|14 GTSE1|PD 7372|196 GFC|RHO 527|7292 J|JCAD|JA 30 M2|SMUR 983|4998| CDK1|OR R-HSA- Reactome 6241|702 C1|RRM2| 1 -3.37978 M1 1 0 6 G1/S-Specific Transcription -3.37978 5.929308 5.053537 24156 28 873 6 0.687285 0.279617 -1.64173 0 109 1 1 -3.37978 5.929308 69205 Gene Sets 9|8318|28 TFDP2|CD 6826 C45|LIN9 ACTN2|C 88|815|12 AMK2A|C 66|1312|2 NN3|CO 890|2902| MT|GRIA1 2913|370 |GRIN1|G GO 6|3739|37 RM3|ITPK GO:00443 Cellular 1 -3.35684 M1 1 0 20 neuron spine -3.35684 2.528988 4.053383 24156 186 873 17 1.947308 0.467671 59|7074|1 A|KCNA4| -1.62347 0 107 0 0 -3.41128 3.074456 09 Compone 1346|228 KCNJ2|TI nts 71|23237| AM1|SYN 26037|57 PO|NLGN 537|8468 1|ARC|SIP 7 A1L1|SOR CS2|PPP1 ADORA2 136|672|1 B|BRCA1| 545|2324| GO CYP1B1|F GO:00105 vascular endothelial growth factor 6095|950 1 -5.40386 M1 1 0 Biological 19 -5.40386 6.917526 6.880087 24156 36 873 9 1.030928 0.341867 LT4|RORA -3.25377 0 47 1 1 -5.40386 6.917526 73 production 8|23213|1 Processes |ADAMTS 47372|72 3|SULF1|C 9230 CBE1|CCR ALK|ASPA 238|443|6 |BMP7|CD 55|1003|1 H5|CRAB 382|1600| P2|DAB1| 1789|189 DNMT3B| 4|2048|23 ECT2|EPH 35|2803|3 B2|FN1|G 280|3706| OLGA4|H 3976|420 ES1|ITPKA 8|4916|51 |LIF|MEF2 21|5270|5 C|NTRK3| 587|5629| PCP4|SER 6387|649 PINE2|PR GO 8|6692|67 KD1|PRO GO:00107 1 -5.35262 M1 1 0 Biological 19 positive regulation of cell development -5.35262 2.098438 5.125114 24156 567 873 43 4.925544 0.732406 90|6935|7 X1|CXCL1 -3.20476 0 29 0 0 -6.42481 3.074456 20 Processes 074|7133| 2|SKIL|SPI 7520|785 NT1|AUR 2|8111|94 KA|ZEB1| 23|9585|1 TIAM1|TN 1141|228 FRSF1B|X 71|27063| RCC5|CX 30812|57 CR4|GPR6 165|1518 8|NTN1|K 35|25926 IF20B|IL1 6|285016| RAPL1|NL 339479|3 GN1|ANK 75567|72 RD1|SOX 9230 8|GJC2|C PNE9|ASP BMP7|LD 655|753|1 LRAD4|ED 908|2335| N3|FN1|H 3280|335 ES1|HTR2 7|4017|40 B|LOXL2| 89|4208|4 SMAD4| 902|5308| MEF2C|N GO 6422|707 RTN|PITX GO:00487 1 -5.33708 M1 1 0 Biological 19 mesenchymal cell differentiation -5.33708 2.919323 5.512182 24156 218 873 23 2.634593 0.542066 4|8854|97 2|SFRP1|T -3.19365 0 28 0 0 -6.45792 4.716495 62 Processes 23|10736| IAM1|ALD 28984|30 H1A2|SE 812|8032 MA3E|SIX 6|157506| 2|RGCC|S 202151|2 OX8|WNT 05717|35 10A|RDH 9845 10|RANB P3L|USF3| ACTC1|A CTN2|SM 70|88|408 AD4|MEF 9|4208|51 2C|PDGF GO 56|5629|7 GO:00302 RA|PROX 1 -5.28359 M1 1 0 Biological 19 myofibril assembly -5.28359 4.882959 6.208806 24156 68 873 12 1.37457 0.394068 139|7140| -3.1489 0 13 0 0 -9.83559 6.28866 39 1|TNNT2| Processes 10324|10 TNNT3|KL 529|2706 HL41|NEB 3|29766 L|ANKRD 1|TMOD3 1062|383 CENPE|KI 2|9493|95 F11|KIF23 GO 85|9928|1 |KIF20B|KI GO:00037 1 -3.35386 M1 1 0 Molecular 21 microtubule motor activity -3.35386 3.59352 4.413742 24156 77 873 10 1.145475 0.360151 1004|241 F14|KIF2C -1.62347 0 46 0 0 -5.44351 7.281606 77 Functions 37|26153| |KIF4A|KIF 81930|34 26A|KIF18 7240 A|KIF24 CDH10|C 1008|113 HRM3|CH 1|1134|25 RNA1|GA GO 56|2557|2 BRA3|GA GO:00989 Cellular intrinsic component of postsynaptic 1 -3.35386 M1 1 0 20 -3.35386 3.59352 4.413742 24156 77 873 10 1.145475 0.360151 890|2902| BRA4|GRI -1.62347 0 58 0 0 -4.67369 3.739203 48 Compone specialization membrane 10369|22 A1|GRIN1 nts 871|3477 |CACNG2| 30 NLGN1|L RRTM1 10051|10 SMC4|SM CORUM:1 1 -3.35124 M1 1 0 CORUM 33 Condensin II -3.35124 16.60206 6.756015 24156 5 873 3 0.343643 0.198061 592|5489 C2|NCAP -1.62347 0 36 0 0 -6.06241 22.13608 60 2 G2 10403|57 NDC80|K CORUM:7 KNL1-MIS12-NDC80-SPC24-ZWINT 1 -3.35124 M1 1 0 CORUM 33 -3.35124 16.60206 6.756015 24156 5 873 3 0.343643 0.198061 082|7900 NL1|MIS1 -1.62347 0 57 0 0 -4.71552 16.60206 542 complex 3 2 CDK1|WE R-HSA- Reactome 983|7465| 1 -3.35124 M1 1 0 6 G2/M DNA replication checkpoint -3.35124 16.60206 6.756015 24156 5 873 3 0.343643 0.198061 E1|CCNB -1.62347 0 110 1 1 -3.35124 18.44674 69478 Gene Sets 9133 2 GO GO:00700 1003|369 CDH5|ITG 1 -3.35124 M1 1 0 Molecular 21 fibrinogen binding -3.35124 16.60206 6.756015 24156 5 873 3 0.343643 0.198061 -1.62347 0 111 1 1 -3.35124 18.44674 51 0|7057 B3|THBS1 Functions BRCA1|BR 672|675|8 CA2|CCN 99|6491|9 F|STIL|CE 662|1073 GO P135|PLK GO:00512 3|25886|5 1 -5.28359 M1 1 0 Biological 19 centrosome duplication -5.28359 4.882959 6.208806 24156 68 873 12 1.37457 0.394068 4|POC1A| -3.1489 0 19 0 0 -7.81934 13.83505 98 4820|551 Processes NDE1|CE 25|55835| P192|CEN 56890|85 PJ|MDM1 459 |CEP295 ACTN2|A DORA2A| CALB2|C 88|135|79 DH9|CDH 4|1007|10 10|CHRM 08|1131|1 3|CHRNA 134|1312| 1|COMT|E 2048|223 PHB2|GP 9|2555|25 C4|GABR 56|2557|2 A2|GABR GO 565|2890| A3|GABR GO:00970 Cellular 1 -3.3504 M1 1 0 20 synaptic membrane -3.3504 1.996812 3.832867 24156 388 873 28 3.207331 0.596329 2902|291 A4|GABR -1.62347 0 58 0 0 -4.67369 3.739203 60 Compone 3|3690|38 G1|GRIA1 nts 38|4916|7 |GRIN1|G 074|1036 RM3|ITGB 9|11141|2 3|KPNA2| 2871|232 NTRK3|TI 37|57537| AM1|CAC 84687|34 NG2|IL1R 7730 APL1|NLG N1|ARC|S ORCS2|P PP1R9B|L ADORA2 A|CALB2| 135|794|8 CAMK2A| 15|1385|1 CREB1|CR 395|1816| HR2|DRD 2048|289 5|EPHB2| 0|2902|32 GRIA1|GR GO 69|3706|4 IN1|HRH1 GO:00481 1 -5.27843 M1 1 0 Biological 19 regulation of synaptic plasticity -5.27843 3.074456 5.543952 24156 189 873 21 2.405498 0.518571 208|5270| |ITPKA|M -3.14589 0 49 1 1 -5.27843 3.609144 67 Processes 10590|11 EF2C|SER 346|2287 PINE2|SC 1|23237|2 GN|SYNP 6037|575 O|NLGN1 37|57616| |ARC|SIPA 347730 1L1|SORC S2|TSHZ3 |LRRTM1 ITGB4|LA 3691|390 Canonical MA3|LAM 1 -3.34087 M158 M1 1 0 11 PID INTEGRIN4 PATHWAY -3.34087 10.06186 5.820912 24156 11 873 4 0.45819 0.22857 9|3914|28 -1.61815 0 77 0 0 -4.11211 18.44674 Pathways B3|LAMA 4217 1 3691|386 ITGB4|KR R-HSA- Reactome 1 -3.34087 M1 1 0 6 Type I hemidesmosome assembly -3.34087 10.06186 5.820912 24156 11 873 4 0.45819 0.22857 1|3909|39 T14|LAM -1.61815 0 77 0 0 -4.11211 18.44674 446107 Gene Sets 14 A3|LAMB GABRA2| GO 2555|255 GO:00085 GABRA3| 1 -3.34087 M1 1 0 Molecular 21 benzodiazepine receptor activity -3.34087 10.06186 5.820912 24156 11 873 4 0.45819 0.22857 6|2557|25 -1.61815 0 112 1 1 -3.34087 10.06186 03 GABRA4| Functions 65 GABRG1 BARD1|B RCA1|CA 580|672|8 SP2|CDK1 35|983|10 |CDK6|CD 21|1030|2 KN2B|GA 619|2620| S1|GAS2|I 3624|366 NHBA|IRF 4|5563|64 6|PRKAA2 GO 98|6790|7 GO:00070 |SKIL|AUR 1 -5.2638 M1 1 0 Biological 19 cell cycle arrest -5.2638 2.813909 5.422281 24156 236 873 24 2.749141 0.553399 029|7057| -3.1334 0 30 0 0 -6.32789 4.035223 50 KA|TFDP2 Processes 9585|270 |THBS1|KI 85|28984| F20B|MTB 51512|79 P|RGCC|G 366|7964 TSE1|HM 8|84687|1 GN5|MCP 44455|33 H1|PPP1R 9479 9B|E2F7|B RINP3 ADORA2 B|FAS|CA SP2|CDK 136|355|8 N2B|COM 35|1030|1 T|CYP24A 312|1591| 1|ITGA2|K 3673|375 CNJ2|MA 9|4214|43 P3K1|MM 16|5179|5 P7|PENK| 366|5563| PMAIP1|P 5587|642 RKAA2|PR 2|7132|87 GO KD1|SFRP GO:00714 72|10631| 1 -5.25088 M1 1 0 Biological 19 cellular response to external stimulus -5.25088 2.470545 5.256156 24156 336 873 30 3.436426 0.616528 1|TNFRSF -3.12262 0 50 1 1 -5.25088 2.470545 96 10991|26 Processes 1A|FADD| 153|2706 POSTN|SL 3|51284|8 C38A3|KI 1788|846 F26A|AN 87|93649| KRD1|TLR 143686|1 7|NUAK2| 54743|44 PPP1R9B| 0738|642 MYOCD|S 658|6529 ESN3|BM 68 T2|MAP1 LC3C|SCX |CASTOR 3832|958 KIF11|KIF GO GO:00085 ATP-dependent microtubule motor activity, 5|9928|26 20B|KIF14 1 -3.33318 M1 1 0 Molecular 21 -3.33318 7.281606 5.303921 24156 19 873 5 0.572738 0.255402 -1.61252 0 46 0 0 -5.44351 7.281606 74 plus-end-directed 153|8193 |KIF26A|KI Functions 0 F18A BRCA1|C 672|835|8 ASP2|CC 94|983|14 ND2|CDK 90|1894|1 1|CCN2|E 908|6790| CT2|EDN 7029|831 3|AURKA| 7|8318|94 TFDP2|CD 93|9585|9 C7|CDC4 787|9928| 5|KIF23|KI GO GO:00900 10403|10 F20B|DLG 1 -5.22312 M1 1 0 Biological 19 positive regulation of cell cycle process -5.22312 2.556973 5.281072 24156 303 873 28 3.207331 0.596329 -3.1012 0 51 1 1 -5.22312 2.912642 68 733|2588 AP5|KIF14 Processes 6|27085|2 |NDC80|P 8984|297 LK4|POC1 66|51203| A|MTBP|R 51512|51 GCC|TM 514|5502 OD3|NUS 3|55835|8 AP1|GTSE 5459|144 1|DTL|PHI 455 P|CENPJ| CEP295|E BUB1|BU 699|701|1 B1B|CENP 062|1063| E|CENPF| 1894|428 ECT2|MKI GO 8|4751|72 67|NEK2| GO:00519 1 -5.20132 M1 1 0 Biological 19 regulation of chromosome segregation -5.20132 3.915581 5.82521 24156 106 873 15 1.718213 0.439813 72|9232|9 TTK|PTTG -3.08149 0 25 0 0 -7.23866 13.83505 83 Processes 319|9787| 1|TRIP13| 10403|10 DLGAP5| 460|1100 NDC80|T 4|56155 ACC3|KIF 2C|TEX14 238|2047| ALK|EPHB 2048|232 1|EPHB2| GO GO:00047 transmembrane receptor protein tyrosine 4|4233|49 FLT4|MET 1 -3.33019 M1 1 0 Molecular 21 -3.33019 3.891108 4.484449 24156 64 873 9 1.030928 0.341867 -1.61163 0 69 0 0 -4.35611 3.891108 14 kinase activity 16|5156|7 |NTRK3|P Functions 075|2846 DGFRA|TI 56 E1|EPHA1 LDLRAD4| CDKN2B| 753|1030| FBN1|FBN 2200|220 2|LTBP1|S 1|4052|40 MAD4|SKI 89|6498|6 L|ZEB1|T GO 935|7057| GO:00170 regulation of transforming growth factor HBS1|AD 1 -5.16518 M1 1 0 Biological 19 -5.16518 3.689347 5.718703 24156 120 873 16 1.832761 0.453972 9719|569 -3.04743 0 6 0 0 -11.8343 3.804639 15 beta receptor signaling pathway AMTSL2| Processes 37|64750| PMEPA1| 65997|93 SMURF2| 649|1171 RASL11B| 66|12485 MYOCD| 7 WFIKKN1| WFIKKN2 ADORA2 A|CDH9|C 135|1007| DH10|CH 1008|113 RM3|CHR 1|1134|20 NA1|EPH GO 48|2556|2 B2|GABR GO:00996 Cellular 1 -3.31826 M1 1 0 20 integral component of synaptic membrane -3.31826 2.69514 4.086329 24156 154 873 15 1.718213 0.439813 557|2890| A3|GABR -1.60135 0 58 0 0 -4.67369 3.739203 99 Compone 2902|291 A4|GRIA1| nts 3|4916|10 GRIN1|GR 369|2287 M3|NTRK 1|347730 3|CACNG 2|NLGN1| LRRTM1 ADORA2 B|ALK|CC 136|238|8 ND2|CDK 94|983|10 1|CENPE| 62|1164|1 CKS2|DA 600|1849| B1|DUSP7 1894|190 |ECT2|ED 8|2247|33 N3|FGF2| 57|3672|3 HTR2B|IT 690|4214| GA1|ITGB 4916|560 3|MAP3K 0|5629|70 1|NTRK3| 57|7074|7 MAPK11| 520|7852| GO PROX1|T GO:00458 8325|876 1 -5.14404 M1 1 0 Biological 19 positive regulation of protein kinase activity -5.14404 2.100878 5.009843 24156 540 873 41 4.696449 0.716032 HBS1|TIA -3.02937 0 18 0 0 -7.89792 2.69514 60 7|9928|99 Processes M1|XRCC 66|10125| 5|CXCR4| 10454|22 FZD8|RIP 974|2898 K2|KIF14| 4|29969|5 TNFSF15| 4757|548 RASGRP1| 92|56034| TAB1|TPX 63967|79 2|RGCC| 444|7986 MDFIC|FA 6|152110| M20A|NC 285016|2 APG2|PD 85489|38 GFC|CLSP 9400 N|BIRC7|B ORA|NEK ALDH1A3 220|2048| |EPHB2|E 2103|253 SRRB|FZD 5|3280|46 2|HES1|M 10|4916|5 YCL|NTRK 629|6935| 3|PROX1| 6939|942 ZEB1|TCF 3|9497|95 GO 15|NTN1| GO:00435 47|10736| 1 -5.14009 M1 1 0 Biological 19 ear development -5.14009 2.841127 5.36055 24156 224 873 23 2.634593 0.542066 SLC4A7|C -3.02937 0 7 0 0 -11.4306 6.148912 83 51141|53 Processes XCL14|SIX 904|6407 2|INSIG2| 2|80184|1 MYO3A|C 16039|11 DH23|CE 7531|133 P290|OSR 060|1575 2|TMC1|O 06|34164 TOP1|RD 0 H10|FRE 983|4751| CDK1|NE 5116|865 K2|PCNT| 5|9662|98 DYNLL1|C 14|10733| EP135|SFI GO GO:00977 ciliary basal body-plasma membrane 54820|55 1|PLK4|N 1 -5.10321 M1 1 0 Biological 19 -5.10321 4.077699 5.819991 24156 95 873 14 1.603666 0.425147 -3.00178 0 12 0 0 -10.0997 6.06468 11 docking 125|5583 DE1|CEP1 Processes 5|79441|8 92|CENPJ| 0184|121 HAUS3|C 441|3472 EP290|NE 40 DD1|KIF2 ADORA2 A|ADORA 2B|AGTR2 135|136|1 |CHRM3| 86|1131|1 CHRNA1| 134|1395| CRHR2|D 1816|255 RD5|GAB 5|2556|25 RA2|GAB 57|2565|2 RA3|GAB KEGG 1 -3.30059 hsa04080 M1 1 0 24 Neuroactive ligand-receptor interaction -3.30059 2.197626 3.881897 24156 277 873 22 2.520046 0.530463 846|2890| RA4|GAB -1.587 0 115 1 1 -3.30059 4.19244 Pathway 2902|291 RG1|LPAR 3|3269|33 4|GRIA1| 57|4161|4 GRIN1|GR 886|6869| M3|HRH1 6915|165 |HTR2B|M 829 C5R|NPY1 R|TACR1| TBXA2R|G PR156 BMP7|CD K6|EDN3| 655|1021| ESRRB|FN 1908|210 1|HES1|H 3|2335|32 TR2B|LIF| 80|3357|3 SMAD4| 976|4089| MEF2C|M 4208|422 EOX1|NR 2|4902|51 GO TN|PDGF GO:00488 56|5308|6 1 -5.08563 M1 1 0 Biological 19 stem cell differentiation -5.08563 2.681212 5.257056 24156 258 873 25 2.863688 0.564477 RA|PITX2| -2.99408 0 28 0 0 -6.45792 4.716495 63 422|7520| Processes SFRP1|XR 8854|972 CC5|ALD 3|10413|3 H1A2|SE 0812|803 MA3E|YA 26|93649| P1|SOX8| 144165|1 WNT10A| 57506|40 MYOCD|P 7738 RICKLE1|R DH10|TAF AGTR2|IN 186|3624| HBA|PMA 5366|642 IP1|SFRP1 GO GO:20012 positive regulation of extrinsic apoptotic 2|6498|70 |SKIL|THB 1 -5.08367 M1 1 0 Biological 19 -5.08367 5.64696 6.305021 24156 49 873 10 1.145475 0.360151 -2.99408 0 52 1 1 -5.08367 9.88218 38 signaling pathway 57|7078|8 S1|TIMP3| Processes 743|8772| TNFSF10| 50486 FADD|G0 S2 CDK1|CR 983|1385| EB1|MEF2 4208|475 C|NEK2|P 1|5116|55 CNT|PRK 63|5600|8 AA2|MAP 655|9662| K11|DYNL 9814|107 L1|CEP13 33|10891| 5|SFI1|PL R-HSA- Reactome 51098|54 K4|PPAR 1 -3.29035 M1 1 0 6 Organelle biogenesis and maintenance -3.29035 2.150042 3.854921 24156 296 873 23 2.634593 0.542066 -1.57919 0 12 0 0 -10.0997 6.06468 1852241 Gene Sets 820|5511 GC1A|IFT 2|55125|5 52|NDE1| 5835|794 WDR60|C 41|79861| EP192|CE 80184|81 NPJ|HAU 027|1214 S3|TUBAL 41|34724 3|CEP290| 0 TUBB1|NE DD1|KIF2 135|186|2 ADORA2 20|355|58 A|AGTR2| 0|655|815 ALDH1A3 |835|1385 |FAS|BAR |1490|154 D1|BMP7| 5|1894|29 CAMK2A| 02|3624|3 CASP2|CR 672|4208| EB1|CCN 4916|536 2|CYP1B1 6|6422|64 |ECT2|GRI 98|7029|7 N1|INHB 057|7074| A|ITGA1| 7078|713 MEF2C|N GO 2|7133|71 TRK3|PM GO:00430 1 -5.07428 M1 1 0 Biological 19 positive regulation of apoptotic process -5.07428 1.95606 4.893167 24156 679 873 48 5.498282 0.771483 53|8743|8 AIP1|SFR -2.98857 0 52 0 0 -5.08367 9.88218 65 Processes 767|8772| P1|SKIL|T 8854|983 FDP2|THB 3|9966|10 S1|TIAM1 276|1089 |TIMP3|T 1|23151|2 NFRSF1A| 3421|260 TNFRSF1 84|27063| B|TOP2A| 28984|29 TNFSF10| 948|5048 RIPK2|FA 6|50650|5 DD|ALDH 3832|840 1A2|MEL 69|90427| K|TNFSF1 196527|6 5|NET1|P 41700 PARGC1A FANCB|F 2187|218 ANCF|DC 8|9937|55 R-HSA- Reactome LRE1A|FA 1 -3.28677 M1 1 0 6 Fanconi Anemia Pathway -3.28677 4.842268 4.709298 24156 40 873 7 0.801833 0.301847 215|9144 -1.57885 0 44 0 0 -5.52611 9.223368 6783310 Gene Sets NCI|FAAP 2|146956| 24|EME1| 353497 POLN BIRC5|BR 332|675|9 CA2|CDK Canonical 83|1063|2 1 -3.28677 M176 M1 1 0 11 PID FOXM1 PATHWAY -3.28677 4.842268 4.709298 24156 40 873 7 0.801833 0.301847 1|CENPF| -1.57885 0 110 0 0 -3.35124 18.44674 Pathways 619|4751| GAS1|NE 9133 K2|CCNB LDLRAD4| CDKN2B| 753|1030| FBN1|FBN 2200|220 2|LTBP1|S 1|4052|40 MAD4|SKI 89|6498|6 L|ZEB1|T GO 935|7057| GO:19038 regulation of cellular response to HBS1|AD 1 -5.07171 M1 1 0 Biological 19 -5.07171 3.628866 5.636721 24156 122 873 16 1.832761 0.453972 9719|569 -2.98793 0 6 0 0 -11.8343 3.804639 44 transforming growth factor beta stimulus AMTSL2| Processes 37|64750| PMEPA1| 65997|93 SMURF2| 649|1171 RASL11B| 66|12485 MYOCD| 7 WFIKKN1| WFIKKN2 CDK1|CE NPI|HELL 983|2491| S|MCM6| 3070|417 MRE11|R 5|4361|59 BBP7|TOP 31|7153|7 2A|XRCC5 520|8208| |CHAF1B| 8357|100 H3C10|S 51|10592| MC4|SMC 23397|23 2|NCAPH| 421|5120 GO ITGB3BP| GO:00711 3|54821|5 1 -5.06619 M1 1 0 Biological 19 DNA conformation change -5.06619 2.461451 5.144251 24156 326 873 29 3.321879 0.606525 NUSAP1| -2.98432 0 31 0 0 -6.31644 12.57732 03 4892|553 Processes ERCC6L|N 55|55506| CAPG2|HJ 55839|57 URP|MAC 082|6415 ROH2A2| 1|79075|7 CENPN|K 9648|801 NL1|NCA 19|91687| PG|DSCC 254394|4 1|MCPH1| 01541|65 PIF1|CEN 3604 PL|MCM9 |CENPP|H BUB1|BU 699|701|1 B1B|CENP 062|1063| E|CENPF| GO 7272|923 GO:00109 regulation of mitotic sister chromatid TTK|PTTG 1 -5.05802 M1 1 0 Biological 19 -5.05802 5.072852 6.116359 24156 60 873 11 1.260023 0.37751 2|9319|97 -2.97806 0 25 0 0 -7.23866 13.83505 65 separation 1|TRIP13| Processes 87|10403| DLGAP5| 10460|56 NDC80|T 155 ACC3|TEX BRCA1|BR 672|675|8 CA2|CAS 35|894|98 P2|CCND 3|1164|14 2|CDK1|C 90|1894|1 KS2|CCN 908|3280| 2|ECT2|E 5629|679 DN3|HES 0|7029|83 1|PROX1| 17|8318|9 AURKA|TF 493|9585| DP2|CDC GO 9787|992 7|CDC45| GO:00457 1 -5.05064 M1 1 0 Biological 19 positive regulation of cell cycle -5.05064 2.300034 5.057396 24156 397 873 33 3.780069 0.645469 8|10403|1 KIF23|KIF -2.97411 0 51 0 0 -5.22312 2.912642 87 Processes 0733|258 20B|DLGA 86|27085| P5|KIF14| 28984|29 NDC80|P 766|5120 LK4|POC1 3|51512|5 A|MTBP|R 1514|550 GCC|TM 23|55835| OD3|NUS 79366|85 AP1|GTSE 459|1444 1|DTL|PHI 55 P|CENPJ| HMGN5| CDK1|CE NPI|HELL 983|2491| S|RBBP7|T 3070|593 OP2A|CH 1|7153|82 AF1B|H3C 08|8357|1 10|SMC4| 0051|105 SMC2|NC 92|23397| APH|ITGB GO 23421|51 GO:00063 3BP|NUS 1 -5.05028 M1 1 0 Biological 19 DNA packaging -5.05028 2.885034 5.325302 24156 211 873 22 2.520046 0.530463 203|5489 -2.97411 0 31 0 0 -6.31644 12.57732 23 AP1|NCA Processes 2|55355|5 PG2|HJUR 5506|558 P|MACRO 39|57082| H2A2|CE 64151|79 NPN|KNL 648|9168 1|NCAPG| 7|401541| MCPH1|C 653604 ENPL|CE NPP|H3C CMKLR1| 1240|190 EDN2|ED 7|1908|22 N3|FGF2| 47|2277|3 VEGFD|IT 673|4233| GA2|MET| GO 4916|522 GO:00509 NTRK3|P 1 -5.02239 M1 1 0 Biological 19 positive regulation of chemotaxis -5.02239 3.433516 5.531059 24156 137 873 17 1.947308 0.467671 8|5587|63 -2.9481 0 42 0 0 -5.75682 3.654542 21 GF|PRKD1 Processes 87|7057|7 |CXCL12| 074|7852| THBS1|TI 9547|196 AM1|CXC 527|7292 R4|CXCL1 30 4|ANO6|C ADORA2 B|ALK|BM P7|CCND 136|238|6 2|CCNF|C 55|894|89 CNG2|CD 9|901|983 K1|CDKN |1030|116 2B|CKS2| 4|1849|19 DUSP7|E 08|2048|2 DN3|EPH 247|3357| B2|FGF2| 3672|421 HTR2B|IT 4|4916|56 GA1|MAP 00|5629|5 3K1|NTRK 795|6422| GO 3|MAPK1 GO:00719 regulation of protein serine/threonine 7057|707 1 -5.01088 M1 1 0 Biological 19 -5.01088 2.09622 4.931651 24156 528 873 40 4.581901 0.707671 1|PROX1| -2.93847 0 18 0 0 -7.89792 2.69514 00 kinase activity 4|7852|83 Processes PTPRJ|SF 25|8767|9 RP1|THBS 133|9134| 1|TIAM1| 10125|10 CXCR4|FZ 454|1107 D8|RIPK2| 2|28984|2 CCNB2|C 9969|547 CNE2|RA 57|56034| SGRP1|TA 79444|85 B1|DUSP1 417|9364 4|RGCC| 9|152110| MDFIC|FA 389400 M20A|PD GFC|BIRC 7|CCNB3| LDLRAD4| CDH5|CD 753|1003| KN2B|CRE 1030|138 B1|FBN1| 5|2200|22 FBN2|LTB 01|4052|4 P1|LTBP2| 053|4089| SMAD4|S 4090|649 GO MAD5|SKI GO:00071 transforming growth factor beta receptor 8|6935|70 1 -4.99717 M1 1 0 Biological 19 -4.99717 2.949605 5.320305 24156 197 873 21 2.405498 0.518571 L|ZEB1|T -2.92844 0 6 0 0 -11.8343 3.804639 79 signaling pathway 57|9719|1 Processes HBS1|AD 0454|569 AMTSL2|T 37|64750| AB1|PME 65997|93 PA1|SMU 649|1171 RF2|RASL 66|12485 11B|MYO 7 CD|WFIKK N1|WFIKK ADORA2 A|ADORA 135|136|1 2B|AGTR2 86|1131|1 |CHRM3| 240|1816| CMKLR1| 1907|190 DRD5|ED 8|2840|28 N2|EDN3| 46|3269|3 GPR17|LP 357|4161| AR4|HRH R-HSA- Reactome 1 -3.26441 M1 1 0 6 Class A/1 (Rhodopsin-like receptors) -3.26441 2.064933 3.800633 24156 335 873 25 2.863688 0.564477 4886|517 1|HTR2B| -1.56292 0 94 0 0 -3.67332 2.548562 373076 Gene Sets 9|6387|68 MC5R|NP 69|6915|7 Y1R|PENK 852|8111| |CXCL12| 10692|50 TACR1|TB 865|5155 XA2R|CX 4|57486|7 CR4|GPR6 29230 8|RRH|HE BP1|ACKR 4|NLN|CC FAS|BRCA 355|675|6 2|BUB1|C 99|835|98 ASP2|CD Canonical 3|1021|56 1 -3.26361 M19 M1 1 0 11 PID P73PATHWAY -3.26361 3.502545 4.314052 24156 79 873 10 1.145475 0.360151 K1|CDK6| -1.56291 0 121 1 1 -3.26361 3.502545 Pathways 00|9134|1 MAPK11| 0413|231 CCNE2|Y 51 AP1|GRA BRCA2|CE 675|1063| NPF|CCN 1490|233 2|FN1|MK 5|4288|43 I67|MRE1 61|6456|7 1|SH3GL2 GO 153|7520| |TOP2A|X GO:00080 1 -3.25069 M1 1 0 Molecular 21 protein C-terminus binding -3.25069 2.475746 3.954411 24156 190 873 17 1.947308 0.467671 9662|104 RCC5|CEP -1.55079 0 122 1 1 -3.25069 2.475746 22 Functions 13|10516| 135|YAP1| 23421|51 FBLN5|IT 098|5513 GB3BP|IF 7|84687|2 T52|FIGN| 84217 PPP1R9B| LAMA1 BMP7|CD 34|COL5A 655|947|1 1|COL7A1 289|1294| |CCN2|FG 1490|224 F2|LOXL2| 7|4017|40 LUM|SMA 60|4090|4 D5|MEF2 208|5081| C|PAX7|P 5744|693 THLH|ZEB GO 5|10736|1 GO:00614 1|SIX2|PP 1 -4.98746 M1 1 0 Biological 19 connective tissue development -4.98746 2.587851 5.156137 24156 278 873 26 2.978236 0.575317 0891|232 -2.92063 0 53 1 1 -4.98746 13.83505 48 ARGC1A| Processes 13|25886| SULF1|PO 30812|55 C1A|SOX 790|6410 8|CSGAL 2|64641|9 NACT1|T 1461|116 NMD|EBF 039|3404 2|PKDCC| 19|35984 OSR2|RSP 5|642658 O2|RFLN B|SCX AGTR2|L DLRAD4|F 186|753|2 BN1|FBN 200|2201| 2|LTBP1|S 4052|642 FRP1|SKIL 2|6498|70 |THBS1|A 57|9719|2 DAMTSL2 GO 3213|569 GO:00902 negative regulation of cellular response to |SULF1|P 1 -4.94607 M1 1 0 Biological 19 -4.94607 3.129357 5.36287 24156 168 873 19 2.176403 0.493838 37|64102| -2.88109 0 6 0 0 -11.8343 3.804639 88 growth factor stimulus MEPA1|T Processes 64750|65 NMD|SM 997|7981 URF2|RAS 2|91851|1 L11B|MM 17166|12 RN2|CHR 4857|375 DL1|WFIK 567 KN1|WFIK KN2|VWC 135|186|2 ADORA2 20|355|58 A|AGTR2| 0|655|815 ALDH1A3 |835|1385 |FAS|BAR |1490|154 D1|BMP7| 5|1894|29 CAMK2A| 02|3624|3 CASP2|CR 672|4208| EB1|CCN 4916|536 2|CYP1B1 6|6422|64 |ECT2|GRI 98|7029|7 N1|INHB 057|7074| A|ITGA1| 7078|713 MEF2C|N GO 2|7133|71 TRK3|PM GO:00430 positive regulation of programmed cell 1 -4.92444 M1 1 0 Biological 19 -4.92444 1.930472 4.794583 24156 688 873 48 5.498282 0.771483 53|8743|8 AIP1|SFR -2.86312 0 52 0 0 -5.08367 9.88218 68 death Processes 767|8772| P1|SKIL|T 8854|983 FDP2|THB 3|9966|10 S1|TIAM1 276|1089 |TIMP3|T 1|23151|2 NFRSF1A| 3421|260 TNFRSF1 84|27063| B|TOP2A| 28984|29 TNFSF10| 948|5048 RIPK2|FA 6|50650|5 DD|ALDH 3832|840 1A2|MEL 69|90427| K|TNFSF1 196527|6 5|NET1|P 41700 PARGC1A ACTL6A|B 86|672|67 RCA1|BR 5|2187|38 CA2|FAN 38|4175|4 CB|KPNA 361|7153| 2|MCM6| 7520|831 MRE11|T 7|8318|91 OP2A|XR 56|9319|5 CC5|CDC 4780|550 7|CDC45| GO GO:00063 10|55137| EXO1|TRI 1 -4.90339 M1 1 0 Biological 19 DNA recombination -4.90339 2.507023 5.068764 24156 298 873 27 3.092784 0.58593 -2.84571 0 54 1 1 -4.90339 3.029573 10 55183|55 P13|NSM Processes 237|8001 CE4A|PAR 0|80119|8 PBP|FIGN| 3933|840 RIF1|VRT 57|11939 N|RMI1|PI 2|146956| F1|HDAC 254394|3 10|MND1 53497|40 |SFR1|EM 1720 E1|MCM9 |POLN|FI LDLRAD4| 753|2200| FBN1|FBN 2201|405 2|LTBP1|S 2|6422|64 FRP1|SKIL 98|8483|9 |CILP|AD GO negative regulation of transmembrane 719|1046 AMTSL2|F GO:00901 1 -4.89107 M1 1 0 Biological 19 receptor protein serine/threonine kinase -4.89107 3.513664 5.477807 24156 126 873 16 1.832761 0.453972 8|56937|6 ST|PMEP -2.83667 0 6 0 0 -11.8343 3.804639 01 Processes signaling pathway 4750|659 A1|SMUR 97|91851| F2|RASL1 117166|1 1B|CHRD 24857|37 L1|WFIKK 5567 N1|WFIKK N2|VWC2 ACTN2|C 88|1393|2 RHBP|EP 048|2890| HB2|GRIA 2902|420 1|GRIN1| GO GO:00996 regulation of neurotransmitter receptor 8|4885|10 MEF2C|N 1 -4.89075 M1 1 0 Biological 19 -4.89075 4.487044 5.817256 24156 74 873 12 1.37457 0.394068 -2.83667 0 45 0 0 -5.5147 9.223368 01 activity 369|1089 PTX2|CAC Processes 1|22871|2 NG2|PPA 3237|729 RGC1A|N 230 LGN1|AR C|CCR2 XIAP|BMP 331|655|1 7|CDH5|F 003|2200| BN1|HES1 3280|408 |SMAD4|S 9|4090|64 MAD5|SF 22|6425|6 RP1|SFRP GO GO:00717 498|6692| 5|SKIL|SPI 1 -4.87217 M1 1 0 Biological 19 response to BMP -4.87217 3.092541 5.301645 24156 170 873 19 2.176403 0.493838 -2.82167 0 55 1 1 -4.87217 18.44674 72 10468|23 NT1|FST|S Processes 213|5696 ULF1|RG 3|64102|6 MA|TNM 4750|918 D|SMURF 51|37556 2|CHRDL 7|642658 1|VWC2|S CX XIAP|BMP 331|655|1 7|CDH5|F 003|2200| BN1|HES1 3280|408 |SMAD4|S 9|4090|64 MAD5|SF 22|6425|6 RP1|SFRP GO GO:00717 498|6692| 5|SKIL|SPI 1 -4.87217 M1 1 0 Biological 19 cellular response to BMP stimulus -4.87217 3.092541 5.301645 24156 170 873 19 2.176403 0.493838 -2.82167 0 55 0 0 -4.87217 18.44674 73 10468|23 NT1|FST|S Processes 213|5696 ULF1|RG 3|64102|6 MA|TNM 4750|918 D|SMURF 51|37556 2|CHRDL 7|642658 1|VWC2|S CX ACTN2|S 88|6456|9 H3GL2|MI 645|9928| CAL2|KIF1 11004|22 4|KIF2C|T 974|2658 PX2|CKAP GO 6|29766|5 GO:00512 2|TMOD3 1 -4.85726 M1 1 0 Biological 19 protein depolymerization -4.85726 3.673023 5.514913 24156 113 873 15 1.718213 0.439813 0853|571 -2.8103 0 40 0 0 -5.92255 5.29853 61 |VILL|TRI Processes 59|81930| M54|KIF1 84687|12 8A|PPP1R 6731|344 9B|CCSAP 148|3472 |NCKAP5| 40 KIF24 ALDH1A3 220|655|2 |BMP7|EP 048|2200| HB2|FBN1 2201|253 |FBN2|FZ 5|3280|42 D2|HES1| 08|4237|5 MEF2C|M 156|5629| FAP2|PD 6491|693 GFRA|PR 5|7054|94 GO OX1|STIL| GO:00485 23|9645|1 1 -4.851 M1 1 0 Biological 19 embryonic organ morphogenesis -4.851 2.490309 5.029553 24156 300 873 27 3.092784 0.58593 ZEB1|TH| -2.80639 0 7 0 0 -11.4306 6.148912 62 0413|107 Processes NTN1|MI 36|51098| CAL2|YAP 51141|53 1|SIX2|IFT 904|5511 52|INSIG2 2|80184|1 |MYO3A| 16039|13 WDR60|C 3060|157 EP290|OS 506|3398 R2|OTOP 29 1|RDH10| ASPA|CD 443|983|1 K1|CREB1 385|1600| |DAB1|HE 3280|397 S1|LIF|NT 6|4916|52 RK3|SERPI GO GO:00140 70|6692|7 NE2|SPIN 1 -4.84716 M1 1 0 Biological 19 regulation of gliogenesis -4.84716 3.485997 5.439085 24156 127 873 16 1.832761 0.453972 -2.80639 0 56 1 1 -4.84716 6.385408 13 074|7133| T1|TIAM1 Processes 7852|308 |TNFRSF1 12|57165| B|CXCR4| 85414|72 SOX8|GJC 9230 2|SLC45A 3|CCR2 EPHB1|EP 2047|204 HB2|ITGB Canonical 8|3690|57 1 -3.20893 M257 M1 1 0 11 PID EPHRINB REV PATHWAY -3.20893 5.534021 4.811634 24156 30 873 6 0.687285 0.279617 3|PTPN13 -1.51845 0 126 1 1 -3.20893 9.223368 Pathways 83|7074|7 |TIAM1|C 852 XCR4 ACTN1|A CTN2|CE NPE|F8|V 87|88|106 EGFD|FN 2|2157|22 1|GP5|GY 77|2335|2 PC|ITGA1| 814|2995| ITGA2|IT 3672|367 GB3|KIF1 3|3690|38 1|MMP1| 32|4312|5 PECAM1| 175|5270| SERPINE2 5321|559 |PLA2G4A 3|6915|70 |PRKG2|T 56|7057|7 BXA2R|T R-HSA- Reactome 078|7465| 1 -3.18179 M1 1 0 6 Hemostasis -3.18179 1.734942 3.595768 24156 622 873 39 4.467354 0.699188 HBD|THB -1.49208 0 108 0 0 -3.3802 5.825285 109582 Gene Sets 8357|949 S1|TIMP3| 3|9585|10 WEE1|H3 125|1018 C10|KIF23 4|11004|2 |KIF20B|R 3414|241 ASGRP1|L 37|26153| HFPL2|KIF 50808|58 2C|ZFPM 494|7986 2|KIF4A|KI 1|81027|8 F26A|AK3 1930|941 |JAM2|TU 21|13918 BAL3|TUB 9|653604 B1|KIF18A |SYTL4|D GKK|H3C GO 2199|220 FBLN2|FB GO:00974 structural molecule activity conferring 1 -3.17736 M1 1 0 Molecular 21 -3.17736 9.223368 5.517304 24156 12 873 4 0.45819 0.22857 0|2201|10 N1|FBN2| -1.49074 0 24 0 0 -7.35548 20.75258 93 elasticity Functions 516 FBLN5 ITGB3BP| 23421|55 CORUM:1 CENPN|C 1 -3.17736 M1 1 0 CORUM 33 CENP-A NAC-CAD complex -3.17736 9.223368 5.517304 24156 12 873 4 0.45819 0.22857 839|9168 -1.49074 0 31 0 0 -6.31644 12.57732 179 ENPL|CE 7|401541 NPP BUB1|BU 699|701|1 B1B|CENP 062|1063| E|CENPF| GO 7272|923 GO:00513 TTK|PTTG 1 -4.84635 M1 1 0 Biological 19 mitotic sister chromatid separation -4.84635 4.831288 5.896045 24156 63 873 11 1.260023 0.37751 2|9319|97 -2.80639 0 25 0 0 -7.23866 13.83505 06 1|TRIP13| Processes 87|10403| DLGAP5| 10460|56 NDC80|T 155 ACC3|TEX ACTN2|C 88|1393|2 RHBP|EP 048|2890| HB2|GRIA GO 2902|420 1|GRIN1| GO:19004 regulation of glutamate receptor signaling 1 -4.84635 M1 1 0 Biological 19 -4.84635 4.831288 5.896045 24156 63 873 11 1.260023 0.37751 8|10369|1 MEF2C|C -2.80639 0 45 0 0 -5.5147 9.223368 49 pathway Processes 0891|228 ACNG2|P 71|23237| PARGC1A 729230 |NLGN1|A RC|CCR2 ALK|EPHB 238|2047| 1|EPHB2| 2048|232 GO FLT4|LTB GO:00191 transmembrane receptor protein kinase 4|4052|42 1 -3.17648 M1 1 0 Molecular 21 -3.17648 3.416062 4.217534 24156 81 873 10 1.145475 0.360151 P1|MET|N -1.49064 0 69 0 0 -4.35611 3.891108 99 activity 33|4916|5 Functions TRK3|PD 156|7075| GFRA|TIE 284656 1|EPHA10 BRCA1|B 672|699|7 UB1|BUB1 01|835|98 B|CASP2| 3|1021|10 CDK1|CD 30|1063|2 K6|CDKN 273|4361| 2B|CENPF 4998|679 |FHL1|MR GO 0|7029|72 E11|ORC1 GO:19019 negative regulation of mitotic cell cycle 1 -4.83984 M1 1 0 Biological 19 -4.83984 2.65633 5.097469 24156 250 873 24 2.749141 0.553399 72|7465|9 |AURKA|T -2.80162 0 4 0 0 -18.6968 4.032327 91 phase transition Processes 319|1040 FDP2|TTK 3|28984|5 |WEE1|TRI 1512|550 P13|NDC 31|56155| 80|RGCC| 57165|63 GTSE1|US 967|1444 P47|TEX1 55 4|GJC2|CL SPN|E2F7 ACTC1|A CTN2|AG 70|88|186 TR2|BMP |655|983| 7|CDK1|C 1385|224 REB1|FGF 7|4089|42 2|SMAD4| 08|5156|5 MEF2C|P 600|5629| DGFRA|M GO GO:00487 6445|713 APK11|PR 1 -4.82914 M1 1 0 Biological 19 cardiac muscle tissue development -4.82914 2.719711 5.118655 24156 234 873 23 2.634593 0.542066 -2.79265 0 13 0 0 -9.83559 6.28866 38 5|7139|88 OX1|SGC Processes 54|10413| G|TNNI1| 10529|23 TNNT2|A 414|2706 LDH1A2|Y 3|54567|5 AP1|NEBL 7538|936 |ZFPM2|A 49 NKRD1|D LL4|ALPK 3|MYOCD BRCA1|B 672|699|7 UB1|BUB1 01|835|98 B|CASP2| 3|1021|10 CDK1|CD 30|1063|2 K6|CDKN 273|4361| 2B|CENPF 4998|679 |FHL1|MR GO 0|7029|72 E11|ORC1 GO:19019 negative regulation of cell cycle phase 1 -4.77317 M1 1 0 Biological 19 -4.77317 2.571571 5.019038 24156 269 873 25 2.863688 0.564477 72|7465|9 |AURKA|T -2.74181 0 4 0 0 -18.6968 4.032327 88 transition Processes 319|1040 FDP2|TTK 3|28984|5 |WEE1|TRI 1512|515 P13|NDC 14|55031| 80|RGCC| 56155|57 GTSE1|DT 165|6396 L|USP47|T 7|144455 EX14|GJC 2|CLSPN| 135|186|2 ADORA2 20|355|58 A|AGTR2| 0|655|815 ALDH1A3 |835|1385 |FAS|BAR |1490|154 D1|BMP7| 5|1894|29 CAMK2A| 02|3039|3 CASP2|CR 624|3672| EB1|CCN 4208|491 2|CYP1B1 6|5366|64 |ECT2|GRI 22|6498|7 N1|HBA1| 029|7057| INHBA|IT 7074|707 GA1|MEF GO 8|7132|71 2C|NTRK3 GO:00109 1 -4.74925 M1 1 0 Biological 19 positive regulation of cell death -4.74925 1.872131 4.662617 24156 739 873 50 5.727377 0.786436 33|7153|8 |PMAIP1| -2.72129 0 52 0 0 -5.08367 9.88218 42 Processes 743|8767| SFRP1|SKI 8772|885 L|TFDP2|T 4|9833|99 HBS1|TIA 66|10206| M1|TIMP 10276|10 3|TNFRSF 891|2315 1A|TNFRS 1|23421|2 F1B|TOP2 6084|270 A|TNFSF1 63|28984| 0|RIPK2|F 29948|50 ADD|ALD 486|5065 H1A2|ME 0|53832|8 LK|TNFSF 4069|904 15|TRIM1 27|19652 3|NET1|P 983|7272| CDK1|TTK GO GO:00345 10403|27 |NDC80| 1 -4.71552 M1 1 0 Biological 19 protein localization to kinetochore -4.71552 9.765919 7.000893 24156 17 873 6 0.687285 0.279617 -2.68925 0 57 1 1 -4.71552 16.60206 01 085|5708 MTBP|KN Processes 2|79003 L1|MIS12 BUB1|BU 699|701|1 B1B|CENP 062|1063| E|CENPF| GO 7272|923 GO:19058 TTK|PTTG 1 -4.71247 M1 1 0 Biological 19 regulation of chromosome separation -4.71247 4.682633 5.75677 24156 65 873 11 1.260023 0.37751 2|9319|97 -2.68788 0 25 0 0 -7.23866 13.83505 18 1|TRIP13| Processes 87|10403| DLGAP5| 10460|56 NDC80|T 155 ACC3|TEX 655|672|6 BMP7|BR 99|701|75 CA1|BUB 3|899|100 1|BUB1B| 3|1063|16 LDLRAD4| 00|1789|2 CCNF|CD 048|3958| H5|CENP 3976|408 F|DAB1|D 9|4233|47 NMT3B|E 51|4974|5 PHB2|LG 587|7057| ALS3|LIF|S 7132|713 MAD4|M 3|7153|72 ET|NEK2| 72|7520|8 OMG|PRK GO 543|9232| D1|THBS1 GO:00511 negative regulation of cellular component 1 -4.67686 M1 1 0 Biological 19 -4.67686 1.847088 4.607154 24156 764 873 51 5.841924 0.793779 9319|942 |TNFRSF1 -2.65727 0 38 0 0 -5.99119 2.543491 29 organization Processes 3|9723|99 A|TNFRSF 28|10403| 1B|TOP2 10631|10 A|TTK|XR 891|2287 CC5|LMO 1|22974|2 4|PTTG1| 6586|270 TRIP13|N 85|28984| TN1|SEM 29766|50 A3E|KIF14 853|5446 |NDC80|P 4|56155|5 OSTN|PP 6890|569 ARGC1A| 37|56963| NLGN1|T 57159|80 PX2|CKAP 119|8016 2|MTBP|R BIRC5|BR 332|672|6 CA1|AUR Canonical 790|9787| 1 -3.12886 M242 M1 1 0 11 PID AURORA A PATHWAY -3.12886 5.355504 4.69869 24156 31 873 6 0.687285 0.279617 KA|DLGA -1.44988 0 128 1 1 -3.12886 18.44674 Pathways 10460|22 P5|TACC3 974 |TPX2 983|1021| CDK1|CD GO GO:00303 1382|299 K6|CRABP 1 -3.12886 M1 1 0 Molecular 21 cyclin binding -3.12886 5.355504 4.69869 24156 31 873 6 0.687285 0.279617 -1.44988 0 129 1 1 -3.12886 5.355504 32 69|90025| 2|MDFIC| Functions 353497 UBE3D|P ADORA2 136|672|1 B|BRCA1| GO 545|2324| GO:00105 regulation of vascular endothelial growth CYP1B1|F 1 -4.65409 M1 1 0 Biological 19 -4.65409 6.510612 6.226211 24156 34 873 8 0.91638 0.322501 6095|232 -2.63944 0 47 0 0 -5.40386 6.917526 74 factor production LT4|RORA Processes 13|14737 |SULF1|C 2|729230 CBE1|CCR AGTR2|B 186|655|9 MP7|CD3 47|2200|3 4|FBN1|H 280|3976| GO ES1|LIF|S GO:00016 4089|515 1 -4.63345 M1 1 0 Biological 19 metanephros development -4.63345 3.952872 5.464665 24156 91 873 13 1.489118 0.40992 MAD4|PD -2.62207 0 10 0 0 -10.1376 3.952872 56 6|10413|1 Processes GFRA|YA 0736|308 P1|SIX2|S 12|11603 OX8|OSR 9|157506 2|RDH10 240|655|1 ALOX5|B 240|1385| MP7|CMK 1600|190 LR1|CREB 7|1908|20 1|DAB1|E 47|2048|2 DN2|EDN 247|2277| 3|EPHB1| 3269|367 EPHB2|FG 2|3673|36 F2|VEGFD 90|3958|4 |HRH1|IT 089|4233| GA1|ITGA 4902|491 2|ITGB3|L 6|5156|52 GALS3|S 28|5587|5 MAD4|M GO 795|6387| ET|NRTN| GO:00069 1 -4.58832 M1 1 0 Biological 19 chemotaxis -4.58832 1.918574 4.593346 24156 649 873 45 5.154639 0.748342 7057|707 NTRK3|P -2.58018 0 29 0 0 -6.42481 3.074456 35 Processes 4|7852|94 DGFRA|P 23|9547|9 GF|PRKD1 723|2376 |PTPRJ|CX 8|51554|5 CL12|THB 4437|558 S1|TIAM1 16|79148| |CXCR4|N 91624|91 TN1|CXCL 653|1126 14|SEMA 16|13358 3E|FLRT2| 4|196527| ACKR4|SE 284217|2 MA5B|DO 84656|64 K5|MMP2 1700|729 8|NEXN|B 230 OC|CMT 331|1003| XIAP|CDH 2200|328 5|FBN1|H 0|4089|64 ES1|SMA GO 22|6425|6 D4|SFRP1 GO:00305 1 -4.5817 M1 1 0 Biological 19 regulation of BMP signaling pathway -4.5817 3.909906 5.414771 24156 92 873 13 1.489118 0.40992 498|1046 |SFRP5|SK -2.57517 0 55 0 0 -4.87217 18.44674 10 Processes 8|23213|6 IL|FST|SU 4750|918 LF1|SMU 51|37556 RF2|CHR 7 DL1|VWC ACTL6A|A LDH1A3| 86|220|65 BMP7|CA 5|835|129 SP2|COL8 5|1545|20 A1|CYP1B 47|2048|2 1|EPHB1| 200|2201| EPHB2|FB 3624|491 N1|FBN2|I 6|5156|53 NHBA|NT GO 08|5629|6 GO:00430 RK3|PDGF 1 -4.57276 M1 1 0 Biological 19 camera-type eye development -4.57276 2.402228 4.81938 24156 311 873 27 3.092784 0.58593 498|6935| -2.56944 0 7 0 0 -11.4306 6.148912 10 RA|PITX2| Processes 7054|885 PROX1|SK 4|11081|3 IL|ZEB1|T 0812|545 H|ALDH1 67|56890| A2|KERA| 57381|11 SOX8|DLL 6039|157 4|MDM1| 506|2842 RHOJ|OS 17 R2|RDH1 0|LAMA1 240|655|1 ALOX5|B 240|1385| MP7|CMK 1600|190 LR1|CREB 7|1908|20 1|DAB1|E 47|2048|2 DN2|EDN 247|2277| 3|EPHB1| 3269|367 EPHB2|FG 2|3673|36 F2|VEGFD 90|3958|4 |HRH1|IT 089|4233| GA1|ITGA 4902|491 2|ITGB3|L 6|5156|52 GALS3|S 28|5587|5 MAD4|M GO 795|6387| ET|NRTN| GO:00423 1 -4.55594 M1 1 0 Biological 19 taxis -4.55594 1.91268 4.571093 24156 651 873 45 5.154639 0.748342 7057|707 NTRK3|P -2.5558 0 29 0 0 -6.42481 3.074456 30 Processes 4|7852|94 DGFRA|P 23|9547|9 GF|PRKD1 723|2376 |PTPRJ|CX 8|51554|5 CL12|THB 4437|558 S1|TIAM1 16|79148| |CXCR4|N 91624|91 TN1|CXCL 653|1126 14|SEMA 16|13358 3E|FLRT2| 4|196527| ACKR4|SE 284217|2 MA5B|DO 84656|64 K5|MMP2 1700|729 8|NEXN|B 230 OC|CMT ACTC1|A DORA2A| ADORA2 70|135|13 B|AGTR2| 6|186|947 CD34|CD |1003|113 H5|CHRM 1|1490|18 3|CCN2|D 16|1907|1 RD5|EDN 908|2313| 2|EDN3|F 3269|335 LI1|HRH1| 7|3672|37 HTR2B|IT 59|3762|4 GA1|KCN 090|4632| J2|KCNJ5| GO 4883|488 SMAD5| GO:00030 1 -4.53228 M1 1 0 Biological 19 circulatory system process -4.53228 1.997841 4.600798 24156 554 873 40 4.581901 0.707671 6|5125|57 MYL1|NP -2.53372 0 61 1 1 -4.53228 18.44674 13 Processes 42|5795|6 R3|NPY1R 387|6445| |PCSK5|P 6915|705 TGS1|PTP 4|7135|71 RJ|CXCL1 36|7139|7 2|SGCG|T 140|7852| BXA2R|T 10266|10 H|TNNI1| 369|1041 TNNI2|TN 3|10631|1 NT2|TNN 0659|545 T3|CXCR4 67|64091 |RAMP2|C ACNG2|Y AP1|POST N|CELF2| BUB1|BU 699|701|4 B1B|MRE 361|9134| 11|CCNE2 GO 9319|100 |TRIP13|S GO:00701 chromosome organization involved in 1 -4.52156 M1 1 0 Biological 19 -4.52156 4.476046 5.558157 24156 68 873 11 1.260023 0.37751 51|10592| MC4|SMC -2.52615 0 9 0 0 -10.3048 5.16914 92 meiotic cell cycle Processes 23397|55 2|NCAPH| 706|8469 NDC1|SP 0|150280 ATA22|H ORMAD2 COL4A5| 1287|128 COL4A6|F Canonical 8|2200|23 1 -3.08989 M53 M1 1 0 11 PID INTEGRIN3 PATHWAY -3.08989 4.504435 4.453668 24156 43 873 7 0.801833 0.301847 BN1|FN1|I -1.42029 0 23 0 0 -7.4807 8.301031 Pathways 35|3690|5 TGB3|PEC 175|7057 AM1|THB VEGFD|FL 2277|232 T4|GAS1| 4|2619|51 PDGFRA| GO 56|5228|5 GO:00359 cellular response to vascular endothelial PGF|PRK 1 -4.52156 M1 1 0 Biological 19 -4.52156 4.476046 5.558157 24156 68 873 11 1.260023 0.37751 587|9508| -2.52615 0 62 1 1 -4.52156 13.83505 24 growth factor stimulus D1|ADAM Processes 10266|54 TS3|RAM 567|5760 P2|DLL4|J 8|147372 CAD|CCB ALDH1A3 220|1381| |CRABP1| 1382|625 R-HSA- Reactome CRABP2|R 1 -3.08989 M1 1 0 6 Signaling by Retinoic Acid -3.08989 4.504435 4.453668 24156 43 873 7 0.801833 0.301847 8|8854|92 -1.42029 0 131 1 1 -3.08989 10.37629 5362517 Gene Sets XRG|ALD 49|15750 H1A2|DH 6 RS3|RDH EPHB1|EP 2047|204 HB2|GPC 8|2239|29 4|GRIN1| 02|4208|4 MEF2C|N GO 916|7058| TRK3|THB GO:00519 1 -4.50244 M1 1 0 Biological 19 regulation of synapse assembly -4.50244 3.620387 5.260173 24156 107 873 14 1.603666 0.425147 9423|111 S2|NTN1|I -2.50859 0 63 1 1 -4.50244 10.37629 63 Processes 41|22871| L1RAPL1| 23768|26 NLGN1|FL 280|5467 RT2|IL1RA 4|347730 PL2|LRRN 3|LRRTM1 87|655|10 ACTN1|B 09|1294|1 MP7|CDH 382|1385| 11|COL7A 1600|204 1|CRABP2 7|2048|23 |CREB1|D 35|2803|2 AB1|EPHB 902|3280| 1|EPHB2| 3690|370 FN1|GOL 6|3914|40 GA4|GRI 89|4208|4 N1|HES1|I 233|4902| TGB3|ITP 4916|497 KA|LAMB 4|5175|56 3|SMAD4| GO 29|6387|6 MEF2C|M GO:00009 cell morphogenesis involved in 1 -4.49261 M1 1 0 Biological 19 -4.49261 1.830033 4.489931 24156 756 873 50 5.727377 0.786436 498|7074| ET|NRTN| -2.50032 0 29 0 0 -6.42481 3.074456 04 differentiation Processes 7852|942 NTRK3|O 3|9723|99 MG|PECA 28|10631| M1|PROX 11141|22 1|CXCL12 871|2323 |SKIL|TIA 7|23768|2 M1|CXCR 6037|260 4|NTN1|S 84|29780| EMA3E|KI 54437|55 F14|POST 816|6410 N|IL1RAP 2|84570|8 L1|NLGN 4612|854 1|ARC|FL 42|91624| RT2|SIPA 91653|13 1L1|ARH BUB1|BU 699|701|1 B1B|CENP 062|1063| E|CENPF| GO GO:00070 metaphase/anaphase transition of mitotic 7272|931 TTK|TRIP1 1 -4.47653 M1 1 0 Biological 19 -4.47653 4.854404 5.641393 24156 57 873 10 1.145475 0.360151 -2.48579 0 25 0 0 -7.23866 13.83505 91 cell cycle 9|9787|10 3|DLGAP5 Processes 403|1046 |NDC80|T 0|56155 ACC3|TEX 14 ALDH1A3 220|655|2 |BMP7|FZ 535|6422| D2|SFRP1 6491|669 |STIL|SPIN 2|8543|88 T1|LMO4| GO 54|9096|9 ALDH1A2 GO:00163 1 -4.46525 M1 1 0 Biological 19 morphogenesis of embryonic epithelium -4.46525 3.115177 5.048653 24156 151 873 17 1.947308 0.467671 585|2321 |TBX18|KI -2.47606 0 64 1 1 -4.46525 3.120688 31 Processes 3|30812|5 F20B|SUL 1098|576 F1|SOX8|I 19|13140 FT52|SHR 5|144165| OOM3|TR 157506 IM71|PRI CKLE1|RD ALDH1A3 220|655|2 |BMP7|FB GO 200|2201| GO:00480 N1|FBN2| 1 -4.46004 M1 1 0 Biological 19 embryonic eye morphogenesis -4.46004 6.148912 5.986448 24156 36 873 8 0.91638 0.322501 4237|562 -2.47506 0 7 0 0 -11.4306 6.148912 48 MFAP2|P Processes 9|6935|70 ROX1|ZEB 54 1|TH ACTC1|C DK1|CEN 70|983|10 PF|CHRN 63|1134|1 A1|CREB1 385|2047| |EPHB1|F 2247|227 GF2|FHL1 3|2275|25 |FHL3|FZ 35|3976|4 D2|LIF|SM 089|4208| AD4|MEF 5081|560 2C|PAX7| 0|5629|64 GO MAPK11| GO:00075 45|6939|7 1 -4.45963 M1 1 0 Biological 19 muscle organ development -4.45963 2.180895 4.646582 24156 406 873 32 3.665521 0.635992 PROX1|S -2.47506 0 13 0 0 -9.83559 6.28866 17 093|7135| Processes GCG|TCF 7139|924 15|TLL2|T 2|10324|1 NNI1|TN 0413|234 NT2|MSC| 14|27063| KLHL41|Y 30812|54 AP1|ZFP 567|5748 M2|ANKR 6|64091|9 D1|SOX8| 3649|642 DLL4|NLN 658 |POPDC2| MYOCD|S BIRC5|FA S|BARD1| 332|355|5 PRDM1|B 80|639|67 RCA1|CA 2|835|983 SP2|CDK1 |4361|536 |MRE11|P 6|5395|55 MAIP1|P 63|5600|5 MS2|PRK 931|6341| AA2|MAP R-HSA- Reactome 6790|702 1 -3.07088 M1 1 0 6 Transcriptional Regulation by TP53 -3.07088 1.971021 3.619594 24156 365 873 26 2.978236 0.575317 K11|RBBP -1.40531 0 101 0 0 -3.49696 2.706858 3700989 Gene Sets 9|7296|91 7|SCO1|A 34|9156|2 URKA|TF 2974|289 DP2|TXN 84|55215| RD1|CCN 55835|80 E2|EXO1| 010|1436 TPX2|RGC 86|14445 C|FANCI| 5 CENPJ|R MI1|SESN ACTN1|A CTN2|CD 87|88|100 H5|CDH7| 3|1005|10 CDH9|CD 07|1008|1 H10|CDH 009|1894| 11|ECT2|F 2335|282 N1|GPM6 4|3673|36 B|ITGA2|I 91|3861|3 TGB4|KRT GO GO:00343 909|3914| 14|LAMA 1 -4.43836 M1 1 0 Biological 19 cell junction organization -4.43836 2.406096 4.737332 24156 299 873 26 2.978236 0.575317 -2.45683 0 39 0 0 -5.93077 3.633448 30 5010|517 3|LAMB3| Processes 5|5795|64 CLDN11| 22|7057|1 PECAM1| 0266|229 PTPRJ|SF 98|64072| RP1|THBS 84612|22 1|RAMP2| 2256|100 LIMCH1|C 506658 DH23|PA RD6B|CD HR3|OCL AGTR2|B 186|655|2 MP7|FGF 247|4089| 2|SMAD4| 4233|522 MET|PGF| 8|5629|64 PROX1|SF 22|6692|9 RP1|SPIN GO 723|1041 GO:00611 T1|SEMA 1 -4.42145 M1 1 0 Biological 19 morphogenesis of a branching epithelium -4.42145 2.872852 4.924465 24156 183 873 19 2.176403 0.493838 3|10736|2 -2.44446 0 10 0 0 -10.1376 3.952872 38 3E|YAP1|S Processes 3213|308 IX2|SULF1 12|54567| |SOX8|DL 157506|2 L4|RDH10 84217|34 |LAMA1|R 0419|441 SPO2|NR 478 ARP ACTC1|A CTN2|AG 70|88|186 TR2|CDK1 |983|3280 |HES1|SM |4089|420 AD4|MEF 8|5156|56 2C|PDGF 29|7139|7 RA|PROX GO GO:00550 140|1026 1|TNNT2| 1 -4.42145 M1 1 0 Biological 19 muscle cell development -4.42145 2.872852 4.924465 24156 183 873 19 2.176403 0.493838 -2.44446 0 13 0 0 -9.83559 6.28866 01 6|10324|1 TNNT3|R Processes 0529|270 AMP2|KL 63|29766| HL41|NEB 57538|11 L|ANKRD 7166|124 1|TMOD3 857 |ALPK3|W FIKKN1|W FIKKN2 BMP7|CD 655|1009| H11|CDK 1021|146 6|VCAN|C 2|1490|15 CN2|CYP 91|2201|2 24A1|FBN 824|4090| 2|GPM6B| 4208|516 SMAD5| 7|5179|55 MEF2C|E 87|5744|6 NPP1|PE 422|9249| NK|PRKD 10736|22 1|PTHLH| GO GO:00015 800|2615 SFRP1|DH 1 -4.41834 M1 1 0 Biological 19 ossification -4.41834 2.170204 4.616038 24156 408 873 32 3.665521 0.635992 -2.44386 0 65 1 1 -4.41834 4.966429 03 6|30812|5 RS3|SIX2| Processes 5790|561 RRAS2|RS 72|91461| L1D1|SOX 91851|11 8|CSGAL 6039|117 NACT1|A 581|1489 NKH|PKD 79|19652 CC|CHRD 7|202151| L1|OSR2| 340419|3 TWIST2|G 59845|64 LIS1|ANO 2658 6|RANBP 3L|RSPO2 AGTR2|PR 186|639|6 DM1|BMP 55|2247|4 7|FGF2|S 089|4233| MAD4|M 5228|562 ET|PGF|P 9|6422|66 ROX1|SFR GO 92|9723|1 P1|SPINT GO:00017 1 -4.41786 M1 1 0 Biological 19 morphogenesis of a branching structure -4.41786 2.780915 4.884776 24156 199 873 20 2.290951 0.50637 0413|107 1|SEMA3 -2.44386 0 10 0 0 -10.1376 3.952872 63 Processes 36|23213| E|YAP1|SI 30812|54 X2|SULF1| 567|1575 SOX8|DLL 06|28421 4|RDH10| 7|340419| LAMA1|R 441478 SPO2|NR ARP STIL|AUR 6491|679 KA|TTK|KI 0|7272|95 F20B|ANL GO 85|54443| GO:00443 N|CEP192 1 -4.4085 M1 1 0 Biological 19 protein localization to cytoskeleton -4.4085 4.770707 5.567209 24156 58 873 10 1.145475 0.360151 55125|79 -2.43599 0 66 1 1 -4.4085 4.770707 80 |MCPH1|P Processes 648|8468 PP1R9B|N 7|121441| EDD1|GA 246176 S2L2 BHMT|D R-HSA- Reactome 635|2995 1 -3.06206 M1 1 0 6 Choline catabolism -3.06206 13.83505 6.088437 24156 6 873 3 0.343643 0.198061 MGDH|C -1.40441 0 134 1 1 -3.06206 27.6701 6798163 Gene Sets 8|55349 HDH 2491|307 CENPI|HE 0|5931|23 LLS|RBBP GO 421|5535 7|ITGB3B GO:00310 1 -4.39797 M1 1 0 Biological 19 chromatin remodeling at centromere -4.39797 5.29853 5.711767 24156 47 873 9 1.030928 0.341867 5|55839|5 P|HJURP| -2.4343 0 31 0 0 -6.31644 12.57732 55 Processes 7082|916 CENPN|K 87|40154 NL1|CEN 1 PL|CENPP KEGG Inosine monophosphate biosynthesis, PRPP 2618|547 GART|PP 1 -3.06206 M00048 M1 1 0 24 -3.06206 13.83505 6.088437 24156 6 873 3 0.343643 0.198061 -1.40441 0 135 1 1 -3.06206 13.83505 Pathway + glutamine => IMP 1|10606 AT|PAICS hsa_M00 KEGG Inosine monophosphate biosynthesis, PRPP 2618|547 GART|PP 1 -3.06206 M1 1 0 24 -3.06206 13.83505 6.088437 24156 6 873 3 0.343643 0.198061 -1.40441 0 135 0 0 -3.06206 13.83505 048 Pathway + glutamine => IMP 1|10606 AT|PAICS CDH5|CD 1003|100 H7|CDH9| 5|1007|10 GO CDH10|C GO:00163 calcium-dependent cell-cell adhesion via 08|1009|2 1 -4.39797 M1 1 0 Biological 19 -4.39797 5.29853 5.711767 24156 47 873 9 1.030928 0.341867 DH11|NL -2.4343 0 32 0 0 -6.28754 6.917526 39 plasma membrane cell adhesion molecules 2871|512 Processes GN1|PCD 94|64072| H12|CDH 222256 23|CDHR FAS|BMP 7|VEGFD| 355|655|2 FLT4|INH 277|2324| BA|LIF|ME 3624|397 T|PDGFR 6|4233|51 A|CXCL12 56|6387|7 |TNFRSF1 132|7133| A|TNFRSF KEGG 1 -3.06087 hsa04060 M1 1 0 24 Cytokine-cytokine receptor interaction -3.06087 2.152119 3.686368 24156 270 873 21 2.405498 0.518571 7852|874 1B|CXCR4 -1.40441 0 21 0 0 -7.62485 2.171781 Pathway 3|9180|95 |TNFSF10| 47|9966|5 OSMR|CX 0615|538 CL14|TNF 32|56034| SF15|IL21 80301|72 R|IL20RA| 9230 PDGFC|PL EKHO2|C CR2 9928|110 KIF14|KIF 04|22974| 2C|TPX2| GO 26586|57 CKAP2|TR GO:00070 1 -4.39797 M1 1 0 Biological 19 microtubule depolymerization -4.39797 5.29853 5.711767 24156 47 873 9 1.030928 0.341867 159|8193 IM54|KIF1 -2.4343 0 40 0 0 -5.92255 5.29853 19 Processes 0|126731| 8A|CCSA 344148|3 P|NCKAP 47240 5|KIF24 CD34|FGF 947|2247| 2|VEGFD| 2277|232 FLT4|HTR 4|3357|36 2B|ITGB3| 90|4017|4 LOXL2|M 208|5228| EF2C|PGF GO 5587|562 GO:00019 |PRKD1|P 1 -4.38679 M1 1 0 Biological 19 endothelial cell proliferation -4.38679 2.76701 4.858902 24156 200 873 20 2.290951 0.50637 9|6387|70 -2.42457 0 68 1 1 -4.38679 2.76701 35 ROX1|CX Processes 57|8854|2 CL12|THB 3213|289 S1|ALDH1 84|54567| A2|SULF1| 57608|64 RGCC|DL 102|4414 L4|JCAD|T 78 NMD|NR BMP7|CD 655|1030| KN2B|INH 3624|405 BA|LTBP1| KEGG 2|4089|40 SMAD4|S 1 -3.0513 hsa04350 M1 1 0 24 TGF-beta signaling pathway -3.0513 3.29406 4.078303 24156 84 873 10 1.145475 0.360151 -1.39659 0 136 1 1 -3.0513 3.816566 Pathway 90|5308|7 MAD5|PIT 057|1046 X2|THBS1 8|64750 |FST|SMU RF2 BUB1|BU B1B|CAM 699|701|8 K2A|CDK 15|983|10 1|CDK6|IT 21|3706|4 PKA|LTBP 052|4214| 1|MAP3K 4751|556 1|NEK2|P 3|5587|55 RKAA2|PR 93|5600|5 KD1|PRK 891|6790| G2|MAPK GO 7272|831 GO:00046 11|MOK| 1 -3.04664 M1 1 0 Molecular 21 protein serine/threonine kinase activity -3.04664 1.861218 3.554723 24156 446 873 30 3.436426 0.616528 7|8767|98 -1.39328 0 16 0 0 -8.49261 2.419993 74 AURKA|T Functions 33|10733| TK|CDC7| 23178|29 RIPK2|ME 941|5390 LK|PLK4|P 4|54757|5 ASK|PKN3 7172|575 |MYO3A|F 38|81788| AM20A|C 84930|14 AMK1G|A 0901|152 LPK3|NU 110 AK2|MAS TL|STK35| BRCA1|BR 672|675|6 CA2|BUB 99|701|47 1|BUB1B| GO 51|6790|1 NEK2|AU GO:00007 Cellular 1 -3.04656 M1 1 0 20 condensed nuclear chromosome -3.04656 3.074456 4.004905 24156 99 873 11 1.260023 0.37751 0403|233 RKA|NDC -1.39328 0 25 0 0 -7.23866 13.83505 94 Compone 97|79003| 80|NCAP nts 83540|15 H|MIS12| 0280 NUF2|HO RMAD2 BMP7|BR 655|672|6 CA1|BUB 99|701|89 1|BUB1B| 9|1003|10 CCNF|CD 63|1789|3 H5|CENP 976|4089| F|DNMT3 4233|475 B|LIF|SMA 1|7153|72 D4|MET| 72|7520|9 NEK2|TO 232|9319| P2A|TTK| GO GO:00106 negative regulation of organelle 10403|10 XRCC5|PT 1 -4.37741 M1 1 0 Biological 19 -4.37741 2.159618 4.585669 24156 410 873 32 3.665521 0.635992 -2.41663 0 38 0 0 -5.99119 2.543491 39 organization 891|2297 TG1|TRIP Processes 4|26586|2 13|NDC8 7085|289 0|PPARG 84|29766| C1A|TPX2 50853|54 |CKAP2|M 464|5615 TBP|RGC 5|56890|5 C|TMOD3 7159|801 |VILL|XRN 19|80169| 1|TEX14| 84952 MDM1|TR IM54|PIF1 ACTC1|A DORA2A| ADORA2 70|135|13 B|AGTR2| 6|186|947 CD34|CD |1003|113 H5|CHRM 1|1490|18 3|CCN2|D 16|1907|1 RD5|EDN 908|2313| 2|EDN3|F 3269|335 LI1|HRH1| 7|3672|37 HTR2B|IT 59|3762|4 GA1|KCN 090|4632| J2|KCNJ5| GO 4883|488 SMAD5| GO:00080 1 -4.36683 M1 1 0 Biological 19 blood circulation -4.36683 1.983702 4.493533 24156 544 873 39 4.467354 0.699188 6|5125|57 MYL1|NP -2.4075 0 61 0 0 -4.53228 18.44674 15 Processes 42|5795|6 R3|NPY1R 387|6445| |PCSK5|P 6915|705 TGS1|PTP 4|7135|71 RJ|CXCL1 36|7139|7 2|SGCG|T 140|7852| BXA2R|T 10266|10 H|TNNI1| 369|1063 TNNI2|TN 1|10659|5 NT2|TNN 4567|640 T3|CXCR4 91 |RAMP2|C ACNG2|P OSTN|CE LF2|DLL4| BUB1|BU 699|701|1 B1B|CENP 062|1063| E|CENPF| GO GO:00447 7272|931 TTK|TRIP1 1 -4.34199 M1 1 0 Biological 19 metaphase/anaphase transition of cell cycle -4.34199 4.689848 5.494702 24156 59 873 10 1.145475 0.360151 -2.38795 0 25 0 0 -7.23866 13.83505 84 9|9787|10 3|DLGAP5 Processes 403|1046 |NDC80|T 0|56155 ACC3|TEX 14 BUB1|BU 699|701|1 B1B|CENP 062|1063| E|CENPF| GO 7272|923 GO:00330 regulation of mitotic sister chromatid TTK|PTTG 1 -4.34154 M1 1 0 Biological 19 -4.34154 4.286917 5.370761 24156 71 873 11 1.260023 0.37751 2|9319|97 -2.38795 0 25 0 0 -7.23866 13.83505 47 segregation 1|TRIP13| Processes 87|10403| DLGAP5| 10460|56 NDC80|T 155 ACC3|TEX GO GABRA2| 2555|255 GO:19027 Cellular GABRA3| 1 -3.03021 M1 1 0 20 GABA-A receptor complex -3.03021 8.513878 5.247245 24156 13 873 4 0.45819 0.22857 6|2557|25 -1.38119 0 112 0 0 -3.34087 10.06186 11 Compone GABRA4| 65 nts GABRG1 GABRA2| GO 2555|255 GO:00228 GABRA3| 1 -3.03021 M1 1 0 Molecular 21 GABA-gated chloride ion channel activity -3.03021 8.513878 5.247245 24156 13 873 4 0.45819 0.22857 6|2557|25 -1.38119 0 112 0 0 -3.34087 10.06186 51 GABRA4| Functions 65 GABRG1 GO 26153|84 KIF26A|P GO:00015 regulation of cell growth by extracellular 1 -4.32747 M1 1 0 Biological 19 -4.32747 27.6701 8.945219 24156 3 873 3 0.343643 0.198061 687|9364 PP1R9B| -2.38094 0 72 1 1 -4.32747 27.6701 60 stimulus Processes 9 MYOCD CDK1|MC 983|4175| M6|ORC1 4998|499 |ORC2|PR 9|5558|62 IM2|RRM R-HSA- Reactome 41|7029|7 1 -3.02705 M1 1 0 6 G1/S Transition -3.02705 2.745888 3.87982 24156 131 873 13 1.489118 0.40992 2|TFDP2| -1.38015 0 20 0 0 -7.69554 7.546392 69206 Gene Sets 465|8317| WEE1|CD 8318|913 C7|CDC4 4|55388|2 5|CCNE2| 86826 MCM10|L GO ENPP1|E GO:00305 5167|516 1 -4.32747 M1 1 0 Biological 19 inorganic diphosphate transport -4.32747 27.6701 8.945219 24156 3 873 3 0.343643 0.198061 NPP3|AN -2.38094 0 73 1 1 -4.32747 27.6701 05 9|56172 Processes KH CDK1|TO 983|7153| P2A|SMC 10051|10 4|SMC2|N GO GO:00302 592|2339 CAPH|NU 1 -4.32183 M1 1 0 Biological 19 chromosome condensation -4.32183 5.188144 5.624097 24156 48 873 9 1.030928 0.341867 -2.3767 0 36 0 0 -6.06241 22.13608 61 7|51203|5 SAP1|NC Processes 4892|641 APG2|NC 51|79648 APG|MCP H1 GABRA2| 2555|255 GO GABRA3| GO:00169 6|2557|25 1 -3.01725 M1 1 0 Molecular 21 GABA receptor activity -3.01725 6.28866 4.805444 24156 22 873 5 0.572738 0.255402 GABRA4| -1.37315 0 112 0 0 -3.34087 10.06186 17 65|16582 Functions GABRG1| 9 GPR156 ALDH1A3 220|1381| |CRABP1| R-HSA- Reactome 1 -3.01725 M1 1 0 6 RA biosynthesis pathway -3.01725 6.28866 4.805444 24156 22 873 5 0.572738 0.255402 8854|924 ALDH1A2 -1.37315 0 131 0 0 -3.08989 10.37629 5365859 Gene Sets 9|157506 |DHRS3|R DH10 CDK1|OR 983|4998| R-HSA- Reactome C1|ORC2| 1 -3.01725 M1 1 0 6 E2F mediated regulation of DNA replication -3.01725 6.28866 4.805444 24156 22 873 5 0.572738 0.255402 4999|555 -1.37315 0 138 1 1 -3.01725 11.06804 113510 Gene Sets PRIM2|TF 8|7029 DP2 AGTR2|B MP7|CHG 186|655|1 B|CCN2|E 114|1490| DN2|EDN 1907|190 3|FBN1|F 8|2200|22 GF2|VEGF 47|2277|3 D|INHBA| 624|3958| LGALS3|LI 3976|490 F|NRTN|O 2|4969|51 GN|PENK| 79|5228|5 PGF|PTHL 744|6387| H|CXCL12 GO GO:00305 8743|954 |TNFSF10| 1 -3.01503 M1 1 0 Molecular 21 receptor regulator activity -3.01503 1.775063 3.493584 24156 530 873 34 3.894616 0.654786 -1.37162 0 21 0 0 -7.62485 2.171781 45 7|9723|99 CXCL14|S Functions 66|10468| EMA3E|T 23768|27 NFSF15|F 123|2994 ST|FLRT2| 8|56034|8 DKK2|OS 0326|112 GIN1|PD 616|1171 GFC|WNT 66|12485 10A|CMT 7|252995| M7|WFIK 407738|7 KN1|WFIK 23961 KN2|FND C5|TAFA1 |INS-IGF2 FAS|BRCA 355|672|3 1|LGALS3| 958|5366| GO PMAIP1|S GO:19020 regulation of extrinsic apoptotic signaling 6422|649 1 -4.27696 M1 1 0 Biological 19 -4.27696 4.611684 5.423805 24156 60 873 10 1.145475 0.360151 FRP1|SKIL -2.33599 0 52 0 0 -5.08367 9.88218 41 pathway via death domain receptors 8|7057|70 Processes |THBS1|TI 78|8743|8 MP3|TNF 772 SF10|FAD ADORA2 A|C4A|CN 135|720|1 N3|SLC31 266|1317| A1|CRHB 1393|160 P|DAB1|E 0|2048|21 PHB2|FAB 73|2890|3 P7|GRIA1| 672|3759| ITGA1|KC 4155|517 NJ2|MBP| 9|5563|64 PENK|PRK 56|6790|7 AA2|SH3 GO 054|7074| GL2|AUR GO:00430 Cellular 1 -3.00558 M1 1 0 20 neuronal cell body -3.00558 1.790418 3.49345 24156 510 873 33 3.780069 0.645469 7133|931 KA|TH|TIA -1.36357 0 41 0 0 -5.7705 2.075258 25 Compone 2|10891|1 M1|TNFR nts 1346|229 SF1B|KCN 74|23237| B2|PPAR 54464|57 GC1A|SY 165|5753 NPO|TPX 7|57565|8 2|ARC|XR 4687|853 N1|GJC2| 97|85442| SORCS2|K 339479|7 LHL14|PP 29230 P1R9B|RG S8|KNDC 1|BRINP3| XIAP|BMP 331|655|1 7|CDH5|F 003|2200| BN1|HES1 3280|408 |SMAD4|S 9|4090|64 MAD5|SF GO 22|6425|6 GO:00305 RP1|SFRP 1 -4.249 M1 1 0 Biological 19 BMP signaling pathway -4.249 2.996126 4.858837 24156 157 873 17 1.947308 0.467671 498|1046 -2.31216 0 55 0 0 -4.87217 18.44674 09 5|SKIL|FST Processes 8|23213|5 |SULF1|R 6963|647 GMA|SM 50|91851| URF2|CH 375567|6 RDL1|VW 42658 C2|SCX AGTR2|B 186|655|9 MP7|CD3 47|2247|3 4|FGF2|H 280|3976| ES1|LIF|S 4089|409 GO MAD4|S GO:00720 0|4208|51 1 -4.24282 M1 1 0 Biological 19 kidney epithelium development -4.24282 3.117758 4.900941 24156 142 873 16 1.832761 0.453972 MAD5|M -2.30773 0 10 0 0 -10.1376 3.952872 73 75|5228|5 Processes EF2C|PEC 420|6422| AM1|PGF| 10413|10 PODXL|SF 736|3081 RP1|YAP1 2 |SIX2|SOX ADORA2 B|ALK|CC 136|238|8 ND2|CDK 94|983|11 1|CKS2|D 64|1849|1 USP7|ED 908|2247| N3|FGF2| 3357|367 HTR2B|IT 2|4214|49 GA1|MAP 16|5600|5 3K1|NTRK GO 629|7057| 3|MAPK1 GO:00719 positive regulation of protein 1 -4.24183 M1 1 0 Biological 19 -4.24183 2.258784 4.546554 24156 343 873 28 3.207331 0.596329 7074|785 1|PROX1| -2.30773 0 18 0 0 -7.89792 2.69514 02 serine/threonine kinase activity Processes 2|8325|87 THBS1|TI 67|10125| AM1|CXC 10454|28 R4|FZD8| 984|2996 RIPK2|RA 9|54757|5 SGRP1|TA 6034|794 B1|RGCC| 44|15211 MDFIC|FA 0|389400 M20A|PD GFC|BIRC 7|NEK10| ACTN1|A CTN2|FN 87|88|233 1|GPM6B| 5|2824|36 ITGA2|IT GO 73|3691|3 GO:00070 GB4|KRT1 1 -4.23993 M1 1 0 Biological 19 cell-substrate junction assembly -4.23993 3.633448 5.084085 24156 99 873 13 1.489118 0.40992 861|3909| -2.30718 0 39 0 0 -5.93077 3.633448 44 4|LAMA3| Processes 3914|579 LAMB3|P 5|6422|70 TPRJ|SFR 57|22998 P1|THBS1 |LIMCH1 CD34|CD 947|8317| C7|KIF23| GO 9493|958 KIF20B|TP GO:00451 Cellular 5|22974|5 1 -2.9956 M1 1 0 20 intercellular bridge -2.9956 3.507478 4.097171 24156 71 873 9 1.030928 0.341867 X2|CEP55| -1.35705 0 140 1 1 -2.9956 3.507478 71 Compone 5165|561 TEX14|HA nts 55|79441| US3|TRIM 80263 45 CHRM3|C 1131|113 HRNA1|D 4|1816|25 RD5|GAB 55|2556|2 RA2|GAB GO GO:00305 557|2565| RA3|GAB 1 -2.99453 M1 1 0 Molecular 21 neurotransmitter receptor activity -2.99453 2.862424 3.893423 24156 116 873 12 1.37457 0.394068 -1.35667 0 112 0 0 -3.34087 10.06186 94 2890|290 RA4|GAB Functions 2|3269|33 RG1|GRIA 57|16582 1|GRIN1| 9 HRH1|HT R2B|GPR1 PRDM1|B MP7|FZD 639|655|2 2|HES1|LT 535|3280| BP1|SMA 4052|408 D4|MEF2 9|4208|51 C|PCSK5| GO 25|5629|7 GO:00032 PROX1|T 1 -4.23321 M1 1 0 Biological 19 cardiac chamber development -4.23321 2.87897 4.802666 24156 173 873 18 2.061856 0.480948 135|7139| -2.30313 0 75 1 1 -4.23321 3.816566 05 NNI1|TN Processes 8543|924 NT2|LMO 9|10454|1 4|DHRS3| 1174|234 TAB1|AD 14|54567| AMTS6|Z 93649 FPM2|DLL 4|MYOCD XIAP|BIRC 331|332|5 5|PMAIP1 KEGG 366|7132| 1 -2.97821 hsa04215 M1 1 0 24 Apoptosis - multiple species -2.97821 5.030928 4.486808 24156 33 873 6 0.687285 0.279617 |TNFRSF1 -1.34172 0 141 1 1 -2.97821 18.44674 Pathway 8772|794 A|FADD|B 44 IRC7 BRCA2|C 675|947|1 D34|CDK 021|1030| 6|CDKN2 1295|217 B|COL8A 3|2247|22 1|FABP7|F 77|2324|3 GF2|VEGF 280|3357| D|FLT4|H 3664|369 ES1|HTR2 0|4017|42 B|IRF6|IT 08|5228|5 GB3|LOXL GO 587|5629| 2|MEF2C| GO:00506 1 -4.23317 M1 1 0 Biological 19 epithelial cell proliferation -4.23317 2.067656 4.451895 24156 455 873 34 3.894616 0.654786 6387|642 PGF|PRK -2.30313 0 68 0 0 -4.38679 2.76701 73 Processes 2|7057|88 D1|PROX 54|9104|1 1|CXCL12 0413|104 |SFRP1|T 68|23213| HBS1|ALD 28984|29 H1A2|RG 128|5109 N|YAP1|F 8|54567|5 ST|SULF1| 7608|641 RGCC|UH 02|11603 RF1|IFT52 9|441478 |DLL4|JCA D|TNMD| 135|136|7 ADORA2 94|815|10 A|ADORA 09|1103|1 2B|CALB2 131|1134| |CAMK2A 1385|139 |CDH11|C 3|1395|18 HAT|CHR 16|2047|2 M3|CHRN 048|2555| A1|CREB1 2556|255 |CRHBP|C 7|2565|28 RHR2|DR 90|2902|2 D5|EPHB1 913|3269| |EPHB2|G 3357|370 ABRA2|G GO 6|3838|41 ABRA3|G GO:00995 1 -4.23054 M1 1 0 Biological 19 synaptic signaling -4.23054 1.811958 4.322702 24156 733 873 48 5.498282 0.771483 55|4208|4 ABRA4|G -2.30185 0 49 0 0 -5.27843 3.609144 36 Processes 885|5179| ABRG1|G 5270|535 RIA1|GRI 4|7054|10 N1|GRM3 590|1114 |HRH1|HT 1|11346|2 R2B|ITPK 2871|232 A|KPNA2| 37|23504| MBP|MEF 26037|55 2C|NPTX2 784|5736 |PENK|SE 9|57537|5 RPINE2|P 7616|846 LP1|TH|S 87|13941 CGN|IL1R 1|222256| APL1|SYN 347730|7 PO|NLGN 135|655|1 ADORA2 009|1382| A|BMP7|C 1385|160 DH11|CR 0|2047|20 ABP2|CRE 48|2335|2 B1|DAB1| 803|2902| EPHB1|EP 3672|370 HB2|FN1| 6|4089|49 GOLGA4| 02|4916|4 GRIN1|IT 974|6387| GA1|ITPK 6456|649 A|SMAD4 8|6642|67 |NRTN|NT 90|7074|7 RK3|OMG GO 465|7852| |CXCL12|S GO:01200 plasma membrane bounded cell projection 1 -4.22755 M1 1 0 Biological 19 -4.22755 1.852909 4.342025 24156 672 873 45 5.154639 0.748342 9423|958 H3GL2|SK -2.3002 0 29 0 0 -6.42481 3.074456 39 morphogenesis Processes 5|9723|10 IL|SNX1|A 631|1114 URKA|TIA 1|22871|2 M1|WEE1 3237|237 |CXCR4|N 68|26037| TN1|KIF2 54437|55 0B|SEMA 816|8457 3E|POST 0|84612|8 N|IL1RAP 5442|916 L1|NLGN 24|91653| 1|ARC|FL 133584|1 RT2|SIPA 51835|28 1L1|SEMA 4217|284 5B|DOK5| 656 COL25A1| ACTN1|C 87|1385|6 REB1|AUR Canonical 790|6935| 1 -2.96836 M71 M1 1 0 11 PID ILK PATHWAY -2.96836 4.304238 4.295969 24156 45 873 7 0.801833 0.301847 KA|ZEB1| -1.3346 0 143 1 1 -2.96836 6.917526 Pathways 9815|104 GIT2|TAC 60|29780 C3|PARV ADORA2 B|ALK|BM 136|238|6 P7|CDK1| 55|983|18 DUSP7|E 49|1908|2 DN3|EPH 048|2247| B2|FGF2| 3357|367 HTR2B|IT 2|4214|49 GA1|MAP 16|5600|5 3K1|NTRK GO 795|6422| 3|MAPK1 GO:00434 1 -4.21978 M1 1 0 Biological 19 regulation of MAP kinase activity -4.21978 2.252218 4.529521 24156 344 873 28 3.207331 0.596329 7057|707 1|PTPRJ|S -2.29377 0 18 0 0 -7.89792 2.69514 05 Processes 4|7852|83 FRP1|THB 25|8767|1 S1|TIAM1 0125|104 |CXCR4|F 54|11072| ZD8|RIPK 29969|56 2|RASGRP 034|7944 1|TAB1|D 4|152110| USP14|M 389400 DFIC|PDG FC|BIRC7| NEK10|GF COL4A5| 1287|128 COL5A1| 9|1299|51 COL9A3| R-HSA- Reactome 1 -2.96243 M1 1 0 6 Signaling by PDGF -2.96243 3.816566 4.15848 24156 58 873 8 0.91638 0.322501 56|7057|7 PDGFRA| -1.33003 0 144 1 1 -2.96243 3.816566 186797 Gene Sets 058|5603 THBS1|TH 4|131873 BS2|PDGF C|COL6A ADORA2 136|672|1 B|BRCA1| GO 545|2324| GO:00105 positive regulation of vascular endothelial CYP1B1|F 1 -4.21382 M1 1 0 Biological 19 -4.21382 6.67899 5.92529 24156 29 873 7 0.801833 0.301847 6095|232 -2.29047 0 47 0 0 -5.40386 6.917526 75 growth factor production LT4|RORA Processes 13|14737 |SULF1|C 2 CBE1 ACTN2|A GTR2|CR 88|186|13 HBP|EPH 93|2048|2 B2|GRIA1| 890|2902| GRIN1|M 4208|488 EF2C|NPT 5|10369|1 GO X2|CACN GO:00104 0891|228 1 -4.20041 M1 1 0 Biological 19 regulation of signaling receptor activity -4.20041 2.862424 4.774213 24156 174 873 18 2.061856 0.480948 G2|PPAR -2.27839 0 45 0 0 -5.5147 9.223368 69 71|23237| Processes GC1A|NL 27123|54 GN1|ARC| 892|1171 DKK2|NC 66|12485 APG2|WFI 7|407738| KKN1|WFI 729230 KKN2|TAF A1|CCR2 ACTN2|C 88|1393|2 RHBP|EP 048|2890| HB2|GRIA 2902|291 1|GRIN1| GO GO:00072 3|4208|70 GRM3|ME 1 -4.19383 M1 1 0 Biological 19 glutamate receptor signaling pathway -4.19383 3.597113 5.039302 24156 100 873 13 1.489118 0.40992 -2.27415 0 45 0 0 -5.5147 9.223368 15 74|10369| F2C|TIAM Processes 10891|22 1|CACNG 871|2323 2|PPARG 7|729230 C1A|NLG N1|ARC|C BUB1|BU 699|701|1 B1B|CENP GO 063|7272| GO:20008 negative regulation of mitotic sister F|TTK|PTT 1 -4.19353 M1 1 0 Biological 19 -4.19353 5.675919 5.658858 24156 39 873 8 0.91638 0.322501 9232|931 -2.27415 0 25 0 0 -7.23866 13.83505 16 chromatid separation G1|TRIP1 Processes 9|10403|5 3|NDC80| 6155 TEX14 ASPA|CD 443|983|1 K1|DAB1| 600|3280| HES1|LIF| GO 3976|491 NTRK3|SE GO:00456 1 -4.17144 M1 1 0 Biological 19 regulation of glial cell differentiation -4.17144 4.113123 5.193464 24156 74 873 11 1.260023 0.37751 6|5270|66 RPINE2|S -2.25507 0 56 0 0 -4.84716 6.385408 85 Processes 92|7133|7 PINT1|TN 852|8541 FRSF1B|C 4 XCR4|SLC 45A3 FAS|BRCA 355|672|3 1|LGALS3| 958|5366| PMAIP1|S GO 6422|649 FRP1|SKIL GO:00086 extrinsic apoptotic signaling pathway via 1 -4.16959 M1 1 0 Biological 19 -4.16959 3.816566 5.096144 24156 87 873 12 1.37457 0.394068 8|7057|70 |THBS1|TI -2.25507 0 52 0 0 -5.08367 9.88218 25 death domain receptors Processes 78|7132|8 MP3|TNF 743|8772| RSF1A|TN 9812 FSF10|FA DD|DELE1 ACTC1|FZ 70|2535|3 D2|LIF|SM 976|4089| AD4|PAX GO 5081|562 7|PROX1| GO:00486 1 -4.16959 M1 1 0 Biological 19 muscle organ morphogenesis -4.16959 3.816566 5.096144 24156 87 873 12 1.37457 0.394068 9|6939|71 TCF15|TN -2.25507 0 75 0 0 -4.23321 3.816566 44 Processes 35|7139|2 NI1|TNNT 3414|270 2|ZFPM2| 63|54567 ANKRD1| DLL4 FAS|CAM 355|815|2 K2A|FGF2 247|2335| |FN1|FZD 2535|367 2|ITGA2|I 3|3690|40 TGB3|LU KEGG 60|4233|5 M|MET|M 1 -2.92937 hsa05205 M1 1 0 24 Proteoglycans in cancer -2.92937 2.317201 3.649314 24156 203 873 17 1.947308 0.467671 -1.30238 0 147 1 1 -2.92937 2.388786 Pathway 600|7057| APK11|TH 7074|707 BS1|TIAM 8|8325|22 1|TIMP3|F 800|8032 ZD8|RRAS 6|117581 2|WNT10 A|TWIST2 CENPE|KI 1062|383 F11|WEE1 2|7465|83 |H3C10|KI 57|9493|9 F23|KIF20 585|1100 B|KIF2C|Z R-HSA- Reactome Factors involved in megakaryocyte 4|23414|2 1 -2.92683 M1 1 0 6 -2.92683 2.470545 3.703626 24156 168 873 15 1.718213 0.439813 FPM2|KIF -1.30051 0 46 0 0 -5.44351 7.281606 983231 Gene Sets development and platelet production 4137|261 4A|KIF26 53|50808| A|AK3|TU 79861|81 BAL3|TUB 027|8193 B1|KIF18A 0|653604 |H3C13 4052|705 LTBP1|TH GO GO:00504 7|22918|1 BS1|CD93 1 -2.9238 M1 1 0 Molecular 21 transforming growth factor beta binding -2.9238 6.01524 4.65952 24156 23 873 5 0.572738 0.255402 -1.29815 0 74 0 0 -4.28019 6.01524 31 17166|12 |WFIKKN1 Functions 4857 |WFIKKN2 AGTR2|B 186|655|9 MP7|CD3 47|2247|3 4|FGF2|H 280|3976| ES1|LIF|S 4089|420 GO MAD4|M GO:00720 8|5156|51 1 -4.16922 M1 1 0 Biological 19 nephron development -4.16922 3.074456 4.834621 24156 144 873 16 1.832761 0.453972 EF2C|PDG -2.25507 0 10 0 0 -10.1376 3.952872 06 75|5228|5 Processes FRA|PECA 420|1041 M1|PGF|P 3|10736|2 ODXL|YA 3213|308 P1|SIX2|S 12 ULF1|SOX 135|655|1 ADORA2 009|1382| A|BMP7|C 1385|160 DH11|CR 0|2047|20 ABP2|CRE 48|2335|2 B1|DAB1| 803|2902| EPHB1|EP 3672|370 HB2|FN1| 6|4089|49 GOLGA4| 02|4916|4 GRIN1|IT 974|6387| GA1|ITPK 6456|649 A|SMAD4 8|6642|67 |NRTN|NT 90|7074|7 RK3|OMG GO 465|7852| |CXCL12|S GO:00488 1 -4.16735 M1 1 0 Biological 19 cell projection morphogenesis -4.16735 1.841945 4.299313 24156 676 873 45 5.154639 0.748342 9423|958 H3GL2|SK -2.2545 0 29 0 0 -6.42481 3.074456 58 Processes 5|9723|10 IL|SNX1|A 631|1114 URKA|TIA 1|22871|2 M1|WEE1 3237|237 |CXCR4|N 68|26037| TN1|KIF2 54437|55 0B|SEMA 816|8457 3E|POST 0|84612|8 N|IL1RAP 5442|916 L1|NLGN 24|91653| 1|ARC|FL 133584|1 RT2|SIPA 51835|28 1L1|SEMA 4217|284 5B|DOK5| 656 COL25A1| ADORA2 135|655|1 A|BMP7|C 009|1382| DH11|CR 1385|160 ABP2|CRE 0|2047|20 B1|DAB1| 48|2335|2 EPHB1|EP 803|2902| HB2|FN1| 3672|370 GOLGA4| 6|4089|49 GRIN1|IT 02|4916|4 GA1|ITPK 974|6387| A|SMAD4 6456|649 |NRTN|NT 8|6790|70 RK3|OMG 74|7465|7 GO |CXCL12|S GO:00488 852|9423| 1 -4.13265 M1 1 0 Biological 19 neuron projection morphogenesis -4.13265 1.85028 4.282041 24156 658 873 44 5.040092 0.740427 H3GL2|SK -2.22109 0 29 0 0 -6.42481 3.074456 12 9585|972 Processes IL|AURKA| 3|10631|1 TIAM1|W 1141|228 EE1|CXCR 71|23237| 4|NTN1|K 23768|26 IF20B|SE 037|5443 MA3E|PO 7|55816|8 STN|IL1R 4570|846 APL1|NLG 12|85442| N1|ARC|F 91624|91 LRT2|SIPA 653|1335 1L1|SEMA 84|15183 5B|DOK5| 5|284217| COL25A1| 284656 PARD6B| 983|7272| CDK1|TTK GO GO:00714 protein localization to chromosome, 10403|27 |NDC80| 1 -4.12744 M1 1 0 Biological 19 -4.12744 7.905744 6.130383 24156 21 873 6 0.687285 0.279617 -2.21846 0 57 0 0 -4.71552 16.60206 59 centromeric region 085|5708 MTBP|KN Processes 2|79003 L1|MIS12 BUB1|BU 699|701|1 B1B|CENP GO 063|7272| GO:19058 negative regulation of chromosome F|TTK|PTT 1 -4.11049 M1 1 0 Biological 19 -4.11049 5.534021 5.557149 24156 40 873 8 0.91638 0.322501 9232|931 -2.20407 0 25 0 0 -7.23866 13.83505 19 separation G1|TRIP1 Processes 9|10403|5 3|NDC80| 6155 TEX14 186|675|9 AGTR2|BR 83|1134|1 CA2|CDK 294|1382| 1|CHRNA 1385|224 1|COL7A1 7|2307|23 |CRABP2| 35|2619|2 CREB1|FG 620|2803| F2|FOXS1 4089|420 |FN1|GAS 8|4886|49 1|GAS2|G 16|5081|5 OLGA4|S 600|5629| MAD4|M 6387|642 EF2C|NPY 2|6456|64 1R|NTRK3 GO 91|6790|7 |PAX7|MA GO:00485 1 -4.10787 M1 1 0 Biological 19 developmental growth -4.10787 1.83111 4.256885 24156 680 873 45 5.154639 0.748342 074|7093| PK11|PRO -2.20273 0 29 0 0 -6.42481 3.074456 89 Processes 7852|942 X1|CXCL1 3|9723|10 2|SFRP1|S 413|1051 H3GL2|ST 6|10631|2 IL|AURKA| 3414|258 TIAM1|TL 86|54437| L2|CXCR4 54892|80 |NTN1|SE 010|8016 MA3E|YA 9|91461|1 P1|FBLN5| 51835|15 POSTN|Z 7506|219 FPM2|PO 770|2592 C1A|SEM 66|34041 A5B|NCA 9 PG2|RMI1 ACTC1|A CTN2|AD ORA2B|A GTR2|CH 70|88|136 RM3|CHR |186|1131 NA1|CCN |1134|149 2|EDN2|E 0|1907|19 DN3|HTR 08|3357|3 2B|ITGA1| 672|3673| ITGA2|KC 3759|376 NJ2|KCNJ 2|4089|40 5|SMAD4| 90|4208|4 SMAD5| GO GO:00030 632|6869| MEF2C|M 1 -4.10335 M1 1 0 Biological 19 muscle system process -4.10335 2.036328 4.35502 24156 462 873 34 3.894616 0.654786 -2.19949 0 61 0 0 -4.53228 18.44674 12 6915|707 YL1|TACR Processes 4|7132|71 1|TBXA2R 33|7135|7 |TIAM1|T 136|7139| NFRSF1A| 7140|785 TNFRSF1 2|9312|10 B|TNNI1| 324|1089 TNNI2|TN 1|23213|2 NT2|TNN 9766|936 T3|CXCR4 49 |KCNB2|K LHL41|PP ARGC1A| SULF1|TM OD3|MY 186|220|2 AGTR2|AL 38|655|67 DH1A3|A 5|835|102 LK|BMP7| 1|1063|13 BRCA2|C 85|1600|2 ASP2|CD 048|2173| K6|CENPF 2618|290 |CREB1|D 2|3280|36 AB1|EPHB 24|4155|5 2|FABP7| 156|5270| GART|GRI 5308|535 N1|HES1|I 4|5629|59 NHBA|MB 92|6095|6 P|PDGFR GO 387|6422| A|SERPIN GO:00603 1 -4.09519 M1 1 0 Biological 19 head development -4.09519 1.764675 4.214811 24156 784 873 50 5.727377 0.786436 6491|705 E2|PITX2| -2.19259 0 78 1 1 -4.09519 2.557741 22 Processes 4|7520|78 PLP1|PRO 52|8655|8 X1|RFX4|R 854|9928| ORA|CXC 10460|10 L12|SFRP 891|1099 1|STIL|TH| 1|26468|5 XRCC5|C 4820|555 XCR4|DY 06|57165| NLL1|ALD 57526|79 H1A2|KIF 648|8018 14|TACC3 4|84687|8 |PPARGC 5442|116 1A|SLC38 039|1394 A3|LHX6| 11|25926 NDE1|MA AGTR2|C 186|1240| MKLR1|C 1395|284 RHR2|GP 0|4161|48 R17|MC5 GO 83|4886|6 R|NPR3|N GO:00016 1 -2.89801 M1 1 0 Molecular 21 peptide receptor activity -2.89801 2.548562 3.708513 24156 152 873 14 1.603666 0.425147 869|7852| PY1R|TAC -1.28286 0 94 0 0 -3.67332 2.548562 53 Functions 10266|51 R1|CXCR4 554|5753 |RAMP2|A 7|114815| CKR4|SO 729230 RCS2|SOR CS1|CCR2 BRCA2|C 675|1164| KS2|MRE1 4361|460 1|MYBL1| 3|6790|71 AURKA|T GO 53|9134|9 OP2A|CC GO:00071 1 -4.06935 M1 1 0 Biological 19 meiosis I -4.06935 3.310953 4.851957 24156 117 873 14 1.603666 0.425147 232|9319| NE2|PTTG -2.16802 0 9 0 0 -10.3048 5.16914 27 Processes 55706|80 1|TRIP13| 010|8405 NDC1|RM 7|84690|1 I1|MND1| 46956 SPATA22| EME1 ASPA|HES 443|3280| 1|LIF|SER 3976|527 PINE2|SPI GO 0|6692|70 GO:00140 NT1|TIAM 1 -4.06312 M1 1 0 Biological 19 positive regulation of gliogenesis -4.06312 4.004883 5.080393 24156 76 873 11 1.260023 0.37751 74|7133|7 -2.16304 0 56 0 0 -4.84716 6.385408 15 1|TNFRSF Processes 852|3081 1B|CXCR4 2|57165|7 |SOX8|GJ 29230 C2|CCR2 2491|553 CENPI|HJ CORUM:7 1 -2.89663 M1 1 0 CORUM 33 CENP-A nucleosomal complex -2.89663 7.905744 5.004711 24156 14 873 4 0.45819 0.22857 55|55839| URP|CEN -1.28286 0 31 0 0 -6.31644 12.57732 388 91687 PN|CENP BMP7|CD 34|CREB1| CCN2|DN 655|947|1 MT3B|VE 385|1490| GFD|ITGA 1789|227 2|LOXL2|S 7|3673|40 MAD4|PE 17|4089|5 NK|PGF|P 179|5228| MAIP1|R 5366|609 ORA|CXC 5|6387|64 GO L12|SFRP GO:00362 22|7054|7 1 -4.05675 M1 1 0 Biological 19 response to decreased oxygen levels -4.05675 2.168738 4.386806 24156 370 873 29 3.321879 0.606525 1|TH|THB -2.15794 0 79 1 1 -4.05675 2.168738 93 057|7852| Processes S1|CXCR4 10266|10 |RAMP2|P 631|1089 OSTN|PP 1|25950|2 ARGC1A| 7063|289 RWDD3|A 84|30001| NKRD1|R 51129|79 GCC|ERO 723|8406 1A|ANGP 9|93649 TL4|SUV3 9H2|PLEK HN1|MY ALDH1A3 |PRDM1|B 220|639|6 MP7|COL 55|1289|1 5A1|COL8 295|2047| A1|EPHB1 2048|220 |EPHB2|F 0|2201|25 BN1|FBN 35|4237|5 GO 2|FZD2|M GO:00905 308|5629| 1 -4.03483 M1 1 0 Biological 19 sensory organ morphogenesis -4.03483 2.419819 4.482979 24156 263 873 23 2.634593 0.542066 FAP2|PIT -2.14048 0 7 0 0 -11.4306 6.148912 96 6935|705 Processes X2|PROX 4|9423|10 1|ZEB1|T 736|3081 H|NTN1|S 2|51141|5 IX2|SOX8| 3904|801 INSIG2|M 84|11603 YO3A|CE 9|133060 P290|OSR 2|OTOP1 GO GABRA2| 2555|255 GO:19027 Cellular GABRA3| 1 -2.89663 M1 1 0 20 GABA receptor complex -2.89663 7.905744 5.004711 24156 14 873 4 0.45819 0.22857 6|2557|25 -1.28286 0 112 0 0 -3.34087 10.06186 10 Compone GABRA4| 65 nts GABRG1 ADORA2 B|ALK|CD 136|238|9 K1|DUSP7 83|1849|1 |EDN3|FG 908|2247| F2|HTR2B 3357|367 |ITGA1|M 2|4214|49 AP3K1|NT 16|5600|7 GO RK3|MAP GO:00434 057|7074| 1 -4.03483 M1 1 0 Biological 19 positive regulation of MAP kinase activity -4.03483 2.419819 4.482979 24156 263 873 23 2.634593 0.542066 K11|THBS -2.14048 0 18 0 0 -7.89792 2.69514 06 7852|832 Processes 1|TIAM1| 5|8767|10 CXCR4|FZ 125|1045 D8|RIPK2| 4|29969|5 RASGRP1| 6034|794 TAB1|MD 44|15211 FIC|PDGF 0|389400 C|BIRC7| NEK10|GF GO 1003|227 CDH5|VE GO:00051 vascular endothelial growth factor receptor 1 -2.89663 M1 1 0 Molecular 21 -2.89663 7.905744 5.004711 24156 14 873 4 0.45819 0.22857 7|3690|52 GFD|ITGB -1.28286 0 137 0 0 -3.04056 10.37629 72 binding Functions 28 3|PGF BMP7|CO 655|1294| L7A1|CC 1490|224 N2|FGF2| 7|4017|40 LOXL2|LU 60|4090|4 M|SMAD 208|5081| 5|MEF2C| 5744|693 GO PAX7|PTH GO:00512 5|10736|2 1 -4.03184 M1 1 0 Biological 19 cartilage development -4.03184 2.610387 4.560275 24156 212 873 20 2.290951 0.50637 LH|ZEB1|S -2.14048 0 53 0 0 -4.98746 13.83505 16 3213|258 Processes IX2|SULF1 86|55790| |POC1A|C 91461|11 SGALNAC 6039|340 T1|PKDC 419|3598 C|OSR2|R 45|64265 SPO2|RFL 8 NB|SCX 1062|104 CENPE|N GO GO:00513 attachment of mitotic spindle microtubules 03|11004| DC80|KIF 1 -4.03183 M1 1 0 Biological 19 -4.03183 9.88218 6.437068 24156 14 873 5 0.572738 0.255402 -2.14048 0 2 0 0 -22.074 10.54099 15 to kinetochore 79003|83 2C|MIS12| Processes 540 NUF2 PMAIP1|S GO positive regulation of extrinsic apoptotic 5366|642 GO:19020 FRP1|SKIL 1 -4.03183 M1 1 0 Biological 19 signaling pathway via death domain -4.03183 9.88218 6.437068 24156 14 873 5 0.572738 0.255402 2|6498|70 -2.14048 0 52 0 0 -5.08367 9.88218 43 |THBS1|TI Processes receptors 57|7078 MP3 GO GO:00314 Cellular BARD1|B 1 -2.8845 M1 1 0 20 BRCA1-BARD1 complex -2.8845 27.6701 7.303589 24156 2 873 2 0.229095 0.161809 580|672 -1.27527 0 70 0 0 -4.32747 27.6701 36 Compone RCA1 nts ACTN1|A 87|88|100 CTN2|CD 3|1005|10 H5|CDH7| 07|1008|1 CDH9|CD 009|2824| H10|CDH GO GO:00343 3673|579 11|GPM6 1 -4.02644 M1 1 0 Biological 19 adherens junction organization -4.02644 2.991362 4.705376 24156 148 873 16 1.832761 0.453972 -2.13841 0 39 0 0 -5.93077 3.633448 32 5|6422|70 B|ITGA2|P Processes 57|10266| TPRJ|SFR 22998|64 P1|THBS1 072|2222 |RAMP2|L 56 IMCH1|C DH23|CD ACTN1|A CTN2|CD 87|88|947 34|CDK6| |1021|149 CCN2|FN 0|2335|28 1|GPM6B| 24|3672|3 ITGA1|IT 673|3690| GO GA2|ITGB GO:00071 3691|517 1 -4.02607 M1 1 0 Biological 19 cell-matrix adhesion -4.02607 2.537433 4.526484 24156 229 873 21 2.405498 0.518571 3|ITGB4|P -2.13841 0 39 0 0 -5.93077 3.633448 60 5|5795|64 Processes ECAM1|P 22|7057|7 TPRJ|SFR 074|9723| P1|THBS1 10516|10 |TIAM1|SE 631|2299 MA3E|FBL 8|158326 N5|POST N|LIMCH BMP7|FZ 655|2535| D2|PODX 5420|562 L|PROX1| 9|6422|64 SFRP1|STI 91|6692|8 L|SPINT1| GO GO:00721 543|9585| LMO4|KIF 1 -4.01991 M1 1 0 Biological 19 epithelial tube formation -4.01991 3.120688 4.74876 24156 133 873 15 1.718213 0.439813 -2.13468 0 64 0 0 -4.46525 3.120688 75 30812|51 20B|SOX8 Processes 098|5761 |IFT52|SH 9|80184|1 ROOM3| 31405|14 CEP290|T 4165 RIM71|PR ICKLE1 135|136|7 ADORA2 94|815|10 A|ADORA 09|1103|1 2B|CALB2 131|1134| |CAMK2A 1385|139 |CDH11|C 3|1395|18 HAT|CHR 16|2047|2 M3|CHRN 048|2555| A1|CREB1 2556|255 |CRHBP|C 7|2565|28 RHR2|DR 90|2902|2 D5|EPHB1 913|3269| |EPHB2|G 3357|370 ABRA2|G GO 6|4155|42 ABRA3|G GO:00995 1 -4.00837 M1 1 0 Biological 19 trans-synaptic signaling -4.00837 1.786394 4.171857 24156 728 873 47 5.383734 0.763867 08|4885|5 ABRA4|G -2.12557 0 49 0 0 -5.27843 3.609144 37 Processes 179|5270| ABRG1|G 5354|705 RIA1|GRI 4|10590|1 N1|GRM3 1141|113 |HRH1|HT 46|22871| R2B|ITPK 23237|23 A|MBP|M 504|2603 EF2C|NPT 7|55784|5 X2|PENK| 7369|575 SERPINE2 37|57616| |PLP1|TH| 84687|13 SCGN|IL1 9411|222 RAPL1|SY 256|3477 NPO|NLG 30|72923 N1|ARC|R 672|6491| BRCA1|ST GO GO:00465 10733|55 IL|PLK4|C 1 -4.00258 M1 1 0 Biological 19 regulation of centriole replication -4.00258 7.546392 5.948259 24156 22 873 6 0.687285 0.279617 -2.12099 0 19 0 0 -7.81934 13.83505 99 835|5689 ENPJ|MD Processes 0|85459 M1|CEP2 ACTN2|C AMK2A|C HRNA1|C 88|815|11 REB1|GAB 34|1385|2 RA2|GAB 555|2556| RA3|GAB 2557|289 RA4|GRIA R-HSA- Reactome Neurotransmitter receptors and 0|2902|37 1 -2.88293 M1 1 0 6 -2.88293 2.294594 3.604457 24156 205 873 17 1.947308 0.467671 1|GRIN1| -1.27498 0 97 0 0 -3.64921 2.294594 112314 Gene Sets postsynaptic signal transmission 59|3762|3 KCNJ2|KC 838|5563| NJ5|KPNA 10369|22 2|PRKAA2 843|7986 |CACNG2| 1|81027 PPM1E|T UBAL3|TU BB1 ALDH1A3 220|2048| |EPHB2|E 2103|253 SRRB|FZD 5|3280|46 2|HES1|M 10|4916|5 YCL|NTRK 629|6935| 3|PROX1| GO 9423|949 GO:00488 ZEB1|NT 1 -3.98736 M1 1 0 Biological 19 inner ear development -3.98736 2.66869 4.553713 24156 197 873 19 2.176403 0.493838 7|9547|51 -2.10697 0 7 0 0 -11.4306 6.148912 39 N1|SLC4A Processes 141|5390 7|CXCL14 4|64072|8 |INSIG2|M 0184|117 YO3A|CD 531|1330 H23|CEP2 60|34164 90|TMC1| 0 OTOP1|F GO 10733|25 PLK4|POC GO:00108 positive regulation of centrosome 1 -3.97647 M1 1 0 Biological 19 -3.97647 13.83505 7.030613 24156 8 873 4 0.45819 0.22857 886|5583 1A|CENPJ -2.09968 0 19 0 0 -7.81934 13.83505 25 duplication Processes 5|85459 |CEP295 ACTN1|C ALB2|CD 87|794|10 H5|ECT2| 03|1894|2 FABP7|IT 173|3690| GB3|KCNJ 3759|501 2|CLDN11 0|5175|54 |PECAM1| 20|5795|7 PODXL|P 074|7223| TPRJ|TIA GO 11346|23 M1|TRPC GO:00059 Cellular 768|5129 1 -2.8691 M1 1 0 20 cell-cell junction -2.8691 1.881846 3.43056 24156 397 873 27 3.092784 0.58593 4|SYNPO| -1.26369 0 132 0 0 -3.08964 3.175258 11 Compone 4|57165|5 FLRT2|PC nts 7369|574 DH12|GJC 81|57608| 2|GJD2|KI 57619|58 AA1210|J 494|8461 CAD|SHR 2|84952|2 OOM3|JA 19770|28 M2|PARD 4217|100 6B|CGNL 506658 1|GJD4|L AMA1|OC ACTL6A|A HR|PRDM 86|196|63 1|CREB1|E 9|1385|20 RG|ESRRB 78|2103|2 |FOXS1|FL 307|2313| I1|H2AZ1| 3015|328 HES1|SM 0|4089|40 AD4|SMA 90|4208|4 D5|MEF2 222|4603| C|MEOX1 4610|477 |MYBL1|M 2|5308|56 GO YCL|NFAT GO:00009 RNA polymerase II proximal promoter 29|5992|6 1 -2.86907 M1 1 0 Molecular 21 -2.86907 1.695023 3.349615 24156 604 873 37 4.238259 0.68184 C1|PITX2| -1.26369 0 82 0 0 -3.95806 2.352519 78 sequence-specific DNA binding 095|6258| Functions PROX1|RF 6498|693 X4|RORA| 5|6936|69 RXRG|SKI 39|7022|8 L|ZEB1|G 726|9242| CFC2|TCF 10413|10 15|TFAP2 732|1073 C|EED|MS 6|23598|6 C|YAP1|T 4641|936 CFL5|SIX2 49|14445 |PATZ1|E 5|642658 BF2|MYO CD|E2F7| BRCA2|M 675|4175| CM6|MRE 4361|499 11|ORC1| 8|4999|55 ORC2|PRI 58|8317|8 M2|CDC7 GO 318|9134| GO:00062 |CDC45|C 1 -3.95717 M1 1 0 Biological 19 DNA-dependent DNA replication -3.95717 2.951478 4.642378 24156 150 873 16 1.832761 0.453972 55388|79 -2.08395 0 20 0 0 -7.69554 7.546392 61 CNE2|MC Processes 075|9266 M10|DSC 7|144455| C1|MGM 146956|2 E1|E2F7|E 54394|35 ME1|MC 3497 M9|POLN 2491|301 CENPI|H2 5|5931|23 AZ1|RBBP 421|5535 7|ITGB3B R-HSA- Reactome Deposition of new CENPA-containing 1 -2.86581 M1 1 0 6 -2.86581 3.365283 3.94588 24156 74 873 9 1.030928 0.341867 5|55839|5 P|HJURP| -1.26298 0 31 0 0 -6.31644 12.57732 606279 Gene Sets nucleosomes at the centromere 7082|916 CENPN|K 87|40154 NL1|CEN 1 PL|CENPP 2491|301 CENPI|H2 5|5931|23 AZ1|RBBP 421|5535 7|ITGB3B R-HSA- Reactome 1 -2.86581 M1 1 0 6 Nucleosome assembly -2.86581 3.365283 3.94588 24156 74 873 9 1.030928 0.341867 5|55839|5 P|HJURP| -1.26298 0 31 0 0 -6.31644 12.57732 774815 Gene Sets 7082|916 CENPN|K 87|40154 NL1|CEN 1 PL|CENPP 672|983|1 BRCA1|C 870|3090| DK1|E2F2| Canonical 4998|624 HIC1|ORC 1 -2.86581 M40 M1 1 0 11 PID E2F PATHWAY -2.86581 3.365283 3.94588 24156 74 873 9 1.030928 0.341867 -1.26298 0 109 0 0 -3.37978 5.929308 Pathways 1|7029|91 1|RRM2|T 34|14445 FDP2|CC 5 NE2|E2F7 BUB1|BU 699|701|1 B1B|CENP GO 063|7272| GO:00330 negative regulation of mitotic sister F|TTK|PTT 1 -3.95217 M1 1 0 Biological 19 -3.95217 5.270496 5.363638 24156 42 873 8 0.91638 0.322501 9232|931 -2.08013 0 25 0 0 -7.23866 13.83505 48 chromatid segregation G1|TRIP1 Processes 9|10403|5 3|NDC80| 6155 TEX14 FAS|BMP 7|CD34|C 355|655|9 REB1|CC 47|1385|1 N2|DNMT 490|1789| 3B|VEGFD 2277|367 |ITGA2|L 3|4017|40 OXL2|SM 89|5179|5 AD4|PEN 228|5366| K|PGF|PM 6095|638 AIP1|ROR GO 7|6422|70 A|CXCL12 GO:00704 1 -3.95027 M1 1 0 Biological 19 response to oxygen levels -3.95027 2.106861 4.289343 24156 394 873 30 3.436426 0.616528 54|7057|7 |SFRP1|T -2.07941 0 79 0 0 -4.05675 2.168738 82 Processes 852|1026 H|THBS1| 6|10631|1 CXCR4|R 0891|259 AMP2|PO 50|27063| STN|PPA 28984|30 RGC1A|R 001|5112 WDD3|A 9|79723|8 NKRD1|R 4069|936 GCC|ERO 49 1A|ANGP TL4|SUV3 9H2|PLEK CMKLR1| 1240|190 EDN2|ED 7|1908|22 N3|VEGF 77|3673|3 D|ITGA2|L 958|5228| GO GALS3|PG GO:00026 6387|705 1 -3.94616 M1 1 0 Biological 19 positive regulation of leukocyte migration -3.94616 3.074456 4.680225 24156 135 873 15 1.718213 0.439813 F|CXCL12| -2.07647 0 42 0 0 -5.75682 3.654542 87 7|8772|95 Processes THBS1|FA 47|58494| DD|CXCL 83483|19 14|JAM2| 6527|729 PLVAP|A 230 NO6|CCR ALDH1A3 |PRDM1|B 220|639|6 MP7|COL 55|1289|1 5A1|COL8 295|2047| A1|EPHB1 GO 2048|220 GO:00485 |EPHB2|F 1 -3.92305 M1 1 0 Biological 19 eye morphogenesis -3.92305 2.931931 4.61127 24156 151 873 16 1.832761 0.453972 0|2201|42 -2.05507 0 7 0 0 -11.4306 6.148912 92 BN1|FBN Processes 37|5308|5 2|MFAP2| 629|6935| PITX2|PR 7054|308 OX1|ZEB1 12|80184 |TH|SOX8| CEP290 BMP7|CD 34|CREB1| 655|947|1 DNMT3B| 385|1789| VEGFD|IT 2277|367 GA2|LOX 3|4017|40 L2|SMAD 89|5179|5 4|PENK|P 228|5366| GF|PMAIP 6095|638 1|RORA|C 7|6422|70 XCL12|SF GO GO:00016 54|7057|7 RP1|TH|T 1 -3.92242 M1 1 0 Biological 19 response to hypoxia -3.92242 2.164142 4.297031 24156 358 873 28 3.207331 0.596329 -2.05507 0 79 0 0 -4.05675 2.168738 66 852|1026 HBS1|CX Processes 6|10631|1 CR4|RAM 0891|259 P2|POST 50|27063| N|PPARG 28984|30 C1A|RWD 001|5112 D3|ANKR 9|79723|8 D1|RGCC| 4069|936 ERO1A|A 49 NGPTL4|S UV39H2| PLEKHN1| BMP7|BR 655|672|9 CA1|CD3 47|1003|1 4|CDH5|C 545|1870| YP1B1|E2 2247|227 F2|FGF2|V 7|4772|52 EGFD|NF 28|5587|6 ATC1|PGF 422|6915| |PRKD1|S 7057|705 FRP1|TBX 8|7075|78 A2R|THBS GO 52|9723|1 1|THBS2| GO:19013 1 -3.91291 M1 1 0 Biological 19 regulation of vasculature development -3.91291 2.040192 4.234224 24156 434 873 32 3.665521 0.635992 0266|105 TIE1|CXC -2.04673 0 15 0 0 -9.08083 2.73285 42 Processes 16|23213| R4|SEMA 28984|51 3E|RAMP 129|5456 2|FBLN5|S 7|57381|5 ULF1|RGC 7608|641 C|ANGPT 02|79812| L4|DLL4|R 93649|14 HOJ|JCAD 7372|641 |TNMD|M 700|7292 MRN2|M 30 YOCD|CC BE1|ECSC BMP7|ED 655|1908| N3|FN1|H 2335|328 ES1|HTR2 GO 0|3357|49 GO:00140 B|NRTN|P 1 -3.90769 M1 1 0 Biological 19 neural crest cell development -3.90769 3.852799 4.917844 24156 79 873 11 1.260023 0.37751 02|5308|8 -2.04498 0 28 0 0 -6.45792 4.716495 32 ITX2|ALD Processes 854|9723| H1A2|SE 30812|15 MA3E|SO 7506 X8|RDH1 FAS|CASP 355|835|3 2|ITGA2|K 673|3759| CNJ2|MA GO 4214|431 GO:00712 P3K1|MM 1 -3.90769 M1 1 0 Biological 19 cellular response to mechanical stimulus -3.90769 3.852799 4.917844 24156 79 873 11 1.260023 0.37751 6|7132|87 -2.04498 0 83 1 1 -3.90769 3.852799 60 P7|TNFRS Processes 72|27063| F1A|FAD 51284|64 D|ANKRD 2658 1|TLR7|SC FGF2|VEG 2247|227 FD|FLT4| 7|2324|33 HTR2B|IT 57|3690|4 GB3|MEF 208|5228| 2C|PGF|P 5587|562 GO RKD1|PR GO:00019 9|6387|70 1 -3.88742 M1 1 0 Biological 19 regulation of endothelial cell proliferation -3.88742 2.706858 4.50034 24156 184 873 18 2.061856 0.480948 OX1|CXC -2.02587 0 68 0 0 -4.38679 2.76701 36 57|8854|2 Processes L12|THBS 3213|289 1|ALDH1 84|54567| A2|SULF1| 57608|64 RGCC|DL 102|4414 L4|JCAD|T 78 NMD|NR 186|238|1 AGTR2|AL 287|1288| K|COL4A 1490|204 5|COL4A6 7|2048|22 |CCN2|EP 47|2277|2 HB1|EPH 324|2902| B2|FGF2| 3672|369 VEGFD|FL 0|4233|49 T4|GRIN1| 02|4916|5 ITGA1|IT 156|5167| GB3|MET| 5228|558 NRTN|NT 7|5600|57 RK3|PDGF 95|6456|6 RA|ENPP GO 503|7057| 1|PGF|PR GO:00071 transmembrane receptor protein tyrosine 1 -3.88378 M1 1 0 Biological 19 -3.88378 1.764579 4.081908 24156 737 873 47 5.383734 0.763867 7074|707 KD1|MAP -2.02567 0 69 0 0 -4.35611 3.891108 69 kinase signaling pathway Processes 5|8483|95 K11|PTPR 08|11082| J|SH3GL2| 23213|23 SLA|THBS 433|2376 1|TIAM1| 8|26037|5 TIE1|CILP| 5023|558 ADAMTS 16|56034| 3|ESM1|S 57608|64 ULF1|RH 102|6428 OQ|FLRT 3|79812|9 2|SIPA1L1 3649|131 |PHIP|DO 405|1436 K5|PDGF 86|14737 C|JCAD|T 2|284656| NMD|AR 672|5931| BRCA1|RB R-HSA- Reactome 6241|702 BP7|RRM 1 -2.83885 M1 1 0 6 Transcriptional Regulation by E2F6 -2.83885 4.743446 4.291401 24156 35 873 6 0.687285 0.279617 -1.24357 0 142 0 0 -2.96836 11.06804 8953750 Gene Sets 9|8317|87 2|TFDP2| 26 CDC7|EE CENPE|A GO 1062|679 URKA|KIF GO:00512 Cellular 0|9585|99 1 -2.83885 M1 1 0 20 spindle midzone -2.83885 4.743446 4.291401 24156 35 873 6 0.687285 0.279617 20B|KIF14 -1.24357 0 155 1 1 -2.83885 13.83505 33 Compone 28|55183| |RIF1|KIF1 nts 81930 8A 135|655|1 ADORA2 009|1382| A|BMP7|C 1385|160 DH11|CR 0|2047|20 ABP2|CRE 48|2335|2 B1|DAB1| 803|2902| EPHB1|EP 3672|370 HB2|FN1| 6|4089|49 GOLGA4| 02|4916|4 GRIN1|IT 974|6387| GA1|ITPK 6456|649 A|SMAD4 8|6642|67 |NRTN|NT 90|7074|7 RK3|OMG GO 465|7852| |CXCL12|S GO:00329 1 -3.87708 M1 1 0 Biological 19 cell part morphogenesis -3.87708 1.789015 4.089943 24156 696 873 45 5.154639 0.748342 9423|958 H3GL2|SK -2.02306 0 29 0 0 -6.42481 3.074456 90 Processes 5|9723|10 IL|SNX1|A 631|1114 URKA|TIA 1|22871|2 M1|WEE1 3237|237 |CXCR4|N 68|26037| TN1|KIF2 54437|55 0B|SEMA 816|8457 3E|POST 0|84612|8 N|IL1RAP 5442|916 L1|NLGN 24|91653| 1|ARC|FL 133584|1 RT2|SIPA 51835|28 1L1|SEMA 4217|284 5B|DOK5| 656 COL25A1| BRCA1|C 672|899|6 CNF|STIL| GO 491|1073 GO:00108 PLK4|POC 1 -3.87662 M1 1 0 Biological 19 regulation of centrosome duplication -3.87662 5.147926 5.271459 24156 43 873 8 0.91638 0.322501 3|25886|5 -2.02306 0 19 0 0 -7.81934 13.83505 24 1A|CENPJ Processes 5835|568 |MDM1|C 90|85459 EP295 2491|593 CENPI|RB 1|23421|5 BP7|ITGB GO GO:00340 5355|558 3BP|HJUR 1 -3.87662 M1 1 0 Biological 19 CENP-A containing nucleosome assembly -3.87662 5.147926 5.271459 24156 43 873 8 0.91638 0.322501 -2.02306 0 31 0 0 -6.31644 12.57732 80 39|57082| P|CENPN| Processes 91687|40 KNL1|CE 1541 NPL|CEN 2491|593 CENPI|RB 1|23421|5 BP7|ITGB GO GO:00616 5355|558 3BP|HJUR 1 -3.87662 M1 1 0 Biological 19 CENP-A containing chromatin organization -3.87662 5.147926 5.271459 24156 43 873 8 0.91638 0.322501 -2.02306 0 31 0 0 -6.31644 12.57732 41 39|57082| P|CENPN| Processes 91687|40 KNL1|CE 1541 NPL|CEN BMP7|CD GO 655|1003| GO:00336 H5|GPR1 1 -2.83533 M1 1 0 Molecular 21 receptor serine/threonine kinase binding -2.83533 5.764605 4.521963 24156 24 873 5 0.572738 0.255402 2840|362 -1.24315 0 157 1 1 -2.83533 11.06804 12 7|INHBA| Functions 4|8772 FADD BRCA1|BR 672|675|2 CA2|FAN 187|4175| CB|MCM6 4361|831 |MRE11|C 7|8318|55 GO DC7|CDC GO:00007 double-strand break repair via 010|5513 1 -3.874 M1 1 0 Biological 19 -3.874 3.029573 4.61295 24156 137 873 15 1.718213 0.439813 45|PARPB -2.02183 0 54 0 0 -4.90339 3.029573 24 homologous recombination 7|55183|8 Processes P|FIGN|RI 0010|119 F1|RMI1|S 392|2543 FR1|MCM 94|35349 9|POLN|FI 7|401720 GNL2 BRCA2|C 675|1164| KS2|MRE1 4361|460 1|MYBL1| 3|6790|71 AURKA|T GO 53|9134|9 OP2A|CC GO:00619 1 -3.87208 M1 1 0 Biological 19 meiosis I cell cycle process -3.87208 3.175258 4.66411 24156 122 873 14 1.603666 0.425147 232|9319| NE2|PTTG -2.02183 0 9 0 0 -10.3048 5.16914 82 Processes 55706|80 1|TRIP13| 010|8405 NDC1|RM 7|84690|1 I1|MND1| 46956 SPATA22| EME1 1063|149 CENPF|C 0|2247|43 CN2|FGF2 61|4751|5 |MRE11|N 073|7520| EK2|PAR 9104|270 N|XRCC5| GO 63|28984| RGN|ANK GO:00718 1 -3.87201 M1 1 0 Biological 19 DNA biosynthetic process -3.87201 2.615582 4.453691 24156 201 873 19 2.176403 0.493838 51514|54 RD1|RGC -2.02183 0 85 1 1 -3.87201 3.458763 97 Processes 108|5446 C|DTL|CH 4|79075|8 RAC1|XR 0119|801 N1|DSCC 69|84690| 1|PIF1|CT 286826|3 C1|SPATA 53497 22|LIN9|P LDLRAD4| 753|2200| FBN1|FBN 2201|405 2|LTBP1|S 2|6498|97 KIL|ADA GO GO:00305 negative regulation of transforming growth 19|56937| MTSL2|P 1 -3.85766 M1 1 0 Biological 19 -3.85766 3.804639 4.865427 24156 80 873 11 1.260023 0.37751 -2.00972 0 6 0 0 -11.8343 3.804639 12 factor beta receptor signaling pathway 64750|65 MEPA1|S Processes 997|1171 MURF2|R 66|12485 ASL11B| 7 WFIKKN1| WFIKKN2 GO 83959|84 SLC4A11| GO:00152 1 -2.83085 M1 1 0 Molecular 21 proton channel activity -2.83085 11.85862 5.563718 24156 7 873 3 0.343643 0.198061 329|1330 HVCN1|O -1.24237 0 158 1 1 -2.83085 11.85862 52 Functions 60 TOP1 BUB1|BU 699|701|1 B1B|CENP 062|1063| GO E|CENPF| GO:00300 regulation of mitotic metaphase/anaphase 7272|931 1 -3.84112 M1 1 0 Biological 19 -3.84112 4.527835 5.071813 24156 55 873 9 1.030928 0.341867 TTK|TRIP1 -1.9972 0 25 0 0 -7.23866 13.83505 71 transition 9|9787|10 Processes 3|DLGAP5 403|5615 |NDC80|T 5 EX14 BRCA1|BR 672|675|2 CA2|FAN 187|4175| CB|MCM6 4361|831 |MRE11|C 7|8318|55 GO DC7|CDC GO:00007 010|5513 1 -3.8385 M1 1 0 Biological 19 recombinational repair -3.8385 3.00762 4.579771 24156 138 873 15 1.718213 0.439813 45|PARPB -1.9972 0 54 0 0 -4.90339 3.029573 25 7|55183|8 Processes P|FIGN|RI 0010|119 F1|RMI1|S 392|2543 FR1|MCM 94|35349 9|POLN|FI 7|401720 GNL2 BMP7|CR 655|1393| HBP|CCN 1490|178 2|DNMT3 9|3015|36 B|H2AZ1|I 73|5179|6 TGA2|PE GO GO:00323 422|7054| NK|SFRP1 1 -3.8385 M1 1 0 Biological 19 response to estradiol -3.8385 3.00762 4.579771 24156 138 873 15 1.718213 0.439813 -1.9972 0 87 1 1 -3.8385 5.234884 55 8854|102 |TH|ALDH Processes 66|10631| 1A2|RAM 10891|81 P2|POST 930|8468 N|PPARG 7 C1A|KIF1 8A|PPP1R 135|136|7 ADORA2 94|815|10 A|ADORA 09|1103|1 2B|CALB2 131|1134| |CAMK2A 1385|139 |CDH11|C 3|1395|18 HAT|CHR 16|2047|2 M3|CHRN 048|2555| A1|CREB1 2556|255 |CRHBP|C 7|2565|28 RHR2|DR 90|2902|2 D5|EPHB1 913|3269| |EPHB2|G 3357|370 ABRA2|G GO 6|4155|42 ABRA3|G GO:00072 1 -3.83163 M1 1 0 Biological 19 chemical synaptic transmission -3.83163 1.767812 4.050146 24156 720 873 46 5.269187 0.756154 08|4885|5 ABRA4|G -1.9944 0 49 0 0 -5.27843 3.609144 68 Processes 179|5270| ABRG1|G 5354|705 RIA1|GRI 4|10590|1 N1|GRM3 1346|228 |HRH1|HT 71|23237| R2B|ITPK 23504|26 A|MBP|M 037|5578 EF2C|NPT 4|57369|5 X2|PENK| 7537|576 SERPINE2 16|84687| |PLP1|TH| 139411|2 SCGN|SY 22256|34 NPO|NLG 7730|729 N1|ARC|R 230 IMBP2|SI VCAN|CY P1B1|CYP 11A1|CYP 1462|154 24A1|GPC 5|1583|15 4|LUM|O 91|2239|4 GN|THBS 060|4969| 1|THBS2| 7057|705 EPM2A|A R-HSA- Reactome 8|7957|95 1 -2.80992 M1 1 0 6 Diseases of metabolism -2.80992 2.145845 3.490608 24156 245 873 19 2.176403 0.493838 DAMTS3| -1.22389 0 33 0 0 -6.2858 7.478406 5668914 Gene Sets 08|9719|1 ADAMTS 1081|111 L2|KERA| 74|54437| ADAMTS 55901|57 6|SEMA5 188|8073 B|THSD1| 1|170692 ADAMTS L3|THSD7 B|ADAMT 135|136|7 ADORA2 94|815|10 A|ADORA 09|1103|1 2B|CALB2 131|1134| |CAMK2A 1385|139 |CDH11|C 3|1395|18 HAT|CHR 16|2047|2 M3|CHRN 048|2555| A1|CREB1 2556|255 |CRHBP|C 7|2565|28 RHR2|DR 90|2902|2 D5|EPHB1 913|3269| |EPHB2|G 3357|370 ABRA2|G GO 6|4155|42 ABRA3|G GO:00989 1 -3.83163 M1 1 0 Biological 19 anterograde trans-synaptic signaling -3.83163 1.767812 4.050146 24156 720 873 46 5.269187 0.756154 08|4885|5 ABRA4|G -1.9944 0 49 0 0 -5.27843 3.609144 16 Processes 179|5270| ABRG1|G 5354|705 RIA1|GRI 4|10590|1 N1|GRM3 1346|228 |HRH1|HT 71|23237| R2B|ITPK 23504|26 A|MBP|M 037|5578 EF2C|NPT 4|57369|5 X2|PENK| 7537|576 SERPINE2 16|84687| |PLP1|TH| 139411|2 SCGN|SY 22256|34 NPO|NLG 7730|729 N1|ARC|R 230 IMBP2|SI 186|220|2 AGTR2|AL 38|655|67 DH1A3|A 5|835|102 LK|BMP7| 1|1063|13 BRCA2|C 85|1600|2 ASP2|CD 048|2173| K6|CENPF 2618|290 |CREB1|D 2|3280|36 AB1|EPHB 24|4155|5 2|FABP7| 270|5308| GART|GRI 5354|562 N1|HES1|I 9|5992|60 NHBA|MB 95|6387|6 P|SERPIN GO 422|6491| E2|PITX2| GO:00074 1 -3.82945 M1 1 0 Biological 19 brain development -3.82945 1.755054 4.042324 24156 741 873 47 5.383734 0.763867 7054|752 PLP1|PRO -1.9944 0 78 0 0 -4.09519 2.557741 20 Processes 0|7852|86 X1|RFX4|R 55|8854|9 ORA|CXC 928|1046 L12|SFRP 0|10891|1 1|STIL|TH| 0991|264 XRCC5|C 68|54820| XCR4|DY 55506|57 NLL1|ALD 165|5752 H1A2|KIF 6|79648|8 14|TACC3 0184|846 |PPARGC 87|85442| 1A|SLC38 139411|2 A3|LHX6| 59266|33 NDE1|MA 9829 CROH2A ACTC1|A CTN2|AG 70|88|186 TR2|CDK1 |983|4089 |SMAD4| |4208|515 MEF2C|P 6|5629|71 DGFRA|P GO 39|7140|1 GO:00550 ROX1|TN 1 -3.8202 M1 1 0 Biological 19 striated muscle cell development -3.8202 2.76701 4.476884 24156 170 873 17 1.947308 0.467671 0324|105 -1.98762 0 13 0 0 -9.83559 6.28866 02 NT2|TNN Processes 29|27063| T3|KLHL4 29766|57 1|NEBL|A 538|1171 NKRD1|T 66|12485 MOD3|AL 7 PK3|WFIK KN1|WFIK 983|6790| CDK1|AU 7029|913 RKA|TFDP R-HSA- Reactome TP53 Regulates Transcription of Cell Cycle 1 -2.79882 M1 1 0 6 -2.79882 4.035223 4.075884 24156 48 873 7 0.801833 0.301847 4|28984|5 2|CCNE2| -1.21523 0 30 0 0 -6.32789 4.035223 6791312 Gene Sets Genes 5835|144 RGCC|CE 455 NPJ|E2F7 BRCA2|C 675|894|9 CND2|CD 83|1908|3 K1|EDN3| 280|6790| HES1|AU 8317|831 RKA|CDC GO 8|9585|97 GO:00459 7|CDC45| 1 -3.8202 M1 1 0 Biological 19 positive regulation of mitotic cell cycle -3.8202 2.76701 4.476884 24156 170 873 17 1.947308 0.467671 87|10403| -1.98762 0 51 0 0 -5.22312 2.912642 31 KIF20B|DL Processes 27085|28 GAP5|ND 984|2976 C80|MTB 6|51203|5 P|RGCC|T 1514|550 MOD3|N 23 USAP1|D CMKLR1| 1240|190 EDN2|ED 7|1908|22 N3|FGF2| 47|2277|3 VEGFD|IT 673|4233| GA2|MET| 4916|515 NTRK3|P GO 6|5228|55 DGFRA|P GO:00509 1 -3.8123 M1 1 0 Biological 19 regulation of chemotaxis -3.8123 2.515464 4.372425 24156 220 873 20 2.290951 0.50637 87|6387|7 GF|PRKD1 -1.98079 0 42 0 0 -5.75682 3.654542 20 Processes 057|7074| |CXCL12| 7852|954 THBS1|TI 7|9723|79 AM1|CXC 148|1965 R4|CXCL1 27|72923 4|SEMA3 0 E|MMP28 |ANO6|C 1062|106 CENPE|CE 3|9787|99 NPF|DLG 28|10403| AP5|KIF14 GO GO:00513 11004|54 |NDC80|K 1 -3.80848 M1 1 0 Biological 19 establishment of chromosome localization -3.80848 3.757668 4.81385 24156 81 873 11 1.260023 0.37751 -1.97804 0 2 0 0 -22.074 10.54099 03 820|5516 IF2C|NDE Processes 5|79003|8 1|CEP55| 1930|835 MIS12|KIF 40 18A|NUF BUB1|BU 699|701|1 B1B|CENP GO 063|7272| GO:00330 negative regulation of sister chromatid F|TTK|PTT 1 -3.80332 M1 1 0 Biological 19 -3.80332 5.030928 5.182102 24156 44 873 8 0.91638 0.322501 9232|931 -1.97609 0 25 0 0 -7.23866 13.83505 46 segregation G1|TRIP1 Processes 9|10403|5 3|NDC80| 6155 TEX14 VEGFD|FL 2277|232 T4|PDGFR GO 4|5156|52 GO:00380 vascular endothelial growth factor signaling A|PGF|PR 1 -3.80332 M1 1 0 Biological 19 -3.80332 5.030928 5.182102 24156 44 873 8 0.91638 0.322501 28|5587|9 -1.97609 0 62 0 0 -4.52156 13.83505 84 pathway KD1|ADA Processes 508|5760 MTS3|JCA 8|147372 D|CCBE1 LDLRAD4| 753|4089| SMAD4|S 6498|270 KIL|ANKR GO GO:00463 63|28984| D1|RGCC| 1 -2.78331 M1 1 0 Molecular 21 SMAD binding -2.78331 3.276723 3.849283 24156 76 873 9 1.030928 0.341867 -1.20335 0 84 0 0 -3.88473 11.06804 32 56937|64 PMEPA1| Functions 750|9364 SMURF2| 9|202151 MYOCD|R ANBP3L STOM|PT 2040|579 PRJ|TNFR 5|7133|22 GO SF1B|CD9 918|5491 GO:00355 Cellular 3|CMTM6 1 -2.78242 M1 1 0 20 specific granule membrane -2.78242 3.040671 3.776521 24156 91 873 10 1.145475 0.360151 8|79895|8 -1.20306 0 161 1 1 -2.78242 3.040671 79 Compone |ATP8B4| 1619|843 nts TSPAN14| 29|19652 HVCN1|A 7|401258 NO6|RAB TNNT2|T GO 7139|714 GO:00055 NNT3|NE 1 -2.77445 M1 1 0 Molecular 21 tropomyosin binding -2.77445 7.378694 4.785099 24156 15 873 4 0.45819 0.22857 0|10529|2 -1.1984 0 61 0 0 -4.53228 18.44674 23 BL|TMOD Functions 9766 3 E2F2|FGF 1870|224 2|VEGFD| 7|2277|23 FLT4|LOX 24|4017|5 L2|PGF|TB 228|6915| XA2R|TH 7057|972 GO BS1|SEM GO:00020 3|10266|1 1 -3.76946 M1 1 0 Biological 19 sprouting angiogenesis -3.76946 2.649265 4.395869 24156 188 873 18 2.061856 0.480948 A3E|RAM -1.94541 0 15 0 0 -9.08083 2.73285 40 1082|545 Processes P2|ESM1| 67|57381| DLL4|RH 57608|79 OJ|JCAD| 812|1444 MMRN2| 55|14737 E2F7|CCB 2|441478 E1|NRAR GO AURKA|D 6790|978 GO:00316 Cellular LGAP5|N 1 -2.77445 M1 1 0 20 spindle pole centrosome -2.77445 7.378694 4.785099 24156 15 873 4 0.45819 0.22857 7|54820|5 -1.1984 0 80 0 0 -4.01173 9.223368 16 Compone DE1|TBCC 5171 nts D1 GABRA2| GO 2555|255 GO:00052 inhibitory extracellular ligand-gated ion GABRA3| 1 -2.77445 M1 1 0 Molecular 21 -2.77445 7.378694 4.785099 24156 15 873 4 0.45819 0.22857 6|2557|25 -1.1984 0 112 0 0 -3.34087 10.06186 37 channel activity GABRA4| Functions 65 GABRG1 BMP7|CO 655|1289| L5A1|COL 1294|129 7A1|COL8 5|2335|36 A1|FN1|I 24|3673|3 NHBA|IT GO 690|3691| GA2|ITGB GO:00073 1 -3.76946 M1 1 0 Biological 19 gastrulation -3.76946 2.649265 4.395869 24156 188 873 18 2.061856 0.480948 3909|391 3|ITGB4|L -1.94541 0 77 0 0 -4.11211 18.44674 69 Processes 4|4089|41 AMA3|LA 55|6422|7 MB3|SMA 296|7358| D4|MBP|S 10736|64 FRP1|TXN 2658 RD1|UGD H|SIX2|SC CENPE|KI 1062|383 F11|SH3G 2|6456|86 L2|DYNLL 55|9493|1 1|KIF23|KI R-HSA- Reactome 1004|241 1 -2.77344 M1 1 0 6 MHC class II antigen presentation -2.77344 2.699522 3.659035 24156 123 873 12 1.37457 0.394068 F2C|KIF4A -1.1984 0 46 0 0 -5.44351 7.281606 2132295 Gene Sets 37|26153| |KIF26A|T 79861|81 UBAL3|TU 027|8193 BB1|KIF18 0|130340 A|AP1S3 1289|233 COL5A1|F GO GO:00433 5|3075|36 N1|CFH|IT 1 -2.77297 M1 1 0 Molecular 21 proteoglycan binding -2.77297 4.611684 4.19917 24156 36 873 6 0.687285 0.279617 -1.1984 0 162 1 1 -2.77297 5.188144 94 73|7057|1 GA2|THB Functions 0468 S1|FST AGTR2|C 186|947|2 D34|FGF2 247|3280| |HES1|LIF| 3976|408 GO SMAD4| GO:00720 9|4208|51 1 -3.76594 M1 1 0 Biological 19 nephron epithelium development -3.76594 3.270103 4.620742 24156 110 873 13 1.489118 0.40992 MEF2C|PE -1.94294 0 10 0 0 -10.1376 3.952872 09 75|5228|5 Processes CAM1|PG 420|1041 F|PODXL| 3|10736|3 YAP1|SIX 0812 2|SOX8 1062|106 CENPE|CE 3|9787|99 NPF|DLG 28|10403| AP5|KIF14 GO GO:00500 11004|54 |NDC80|K 1 -3.76013 M1 1 0 Biological 19 chromosome localization -3.76013 3.711843 4.763087 24156 82 873 11 1.260023 0.37751 -1.93923 0 2 0 0 -22.074 10.54099 00 820|5516 IF2C|NDE Processes 5|79003|8 1|CEP55| 1930|835 MIS12|KIF 40 18A|NUF LDLRAD4| 753|2200| FBN1|FBN 2201|405 2|LTBP1|S 2|6498|97 KIL|ADA GO GO:19038 negative regulation of cellular response to 19|56937| MTSL2|P 1 -3.76013 M1 1 0 Biological 19 -3.76013 3.711843 4.763087 24156 82 873 11 1.260023 0.37751 -1.93923 0 6 0 0 -11.8343 3.804639 45 transforming growth factor beta stimulus 64750|65 MEPA1|S Processes 997|1171 MURF2|R 66|12485 ASL11B| 7 WFIKKN1| WFIKKN2 GO TNNI1|TN 7135|713 GO:00058 Cellular NI2|TNNT 1 -2.7514 M1 1 0 20 striated muscle thin filament -2.7514 5.534021 4.391946 24156 25 873 5 0.572738 0.255402 6|7139|71 -1.1792 0 61 0 0 -4.53228 18.44674 65 Compone 2|TNNT3| 40|29766 nts TMOD3 PRDM1|B MP7|BRC 639|655|6 A2|CASP2 75|835|89 |CCNF|CO 9|1299|21 L9A3|ESR 03|2620|3 RB|GAS2| 280|3624| HES1|INH 3976|408 BA|LIF|SM 9|5156|52 AD4|PDG 70|6422|6 FRA|SERP 692|7022| INE2|SFR GO 8743|104 GO:00614 P1|SPINT 1 -3.75072 M1 1 0 Biological 19 reproductive system development -3.75072 1.998743 4.10822 24156 443 873 32 3.665521 0.635992 68|10733| -1.93219 0 89 1 1 -3.75072 2.95506 58 1|TFAP2C Processes 23213|23 |TNFSF10| 414|2359 FST|PLK4| 8|30812|5 SULF1|ZF 1294|819 PM2|PAT 30|84687| Z1|SOX8| 93649|14 PCDH12| 4455|157 KIF18A|P 506|2592 PP1R9B| 66|64265 MYOCD|E 8 2F7|RDH1 0|ASPM|S CDK1|CR 983|1385| EB1|DNM 1789|367 T3B|ITGA GO 3|5563|70 GO:00148 2|PRKAA2 1 -3.74989 M1 1 0 Biological 19 response to activity -3.74989 4.01016 4.848573 24156 69 873 10 1.145475 0.360151 54|7852|1 -1.93219 0 90 1 1 -3.74989 8.301031 23 |TH|CXCR Processes 0631|108 4|POSTN| 91|25299 PPARGC1 5 A|FNDC5 ACTL6A|B ARD1|BR 86|580|67 CA1|BRC 2|675|983 A2|CDK1| |2187|218 FANCB|F 8|4175|43 ANCF|MC 61|5395|7 M6|MRE1 520|8208| 1|PMS2|X 8317|831 RCC5|CH 8|9156|92 AF1B|CD 32|9319|9 C7|CDC4 937|2912 5|EXO1|P 8|51514|5 TTG1|TRI GO 4780|550 P13|DCLR GO:00062 1 -3.74624 M1 1 0 Biological 19 DNA repair -3.74624 1.870932 4.045227 24156 562 873 38 4.352806 0.690579 10|55031| E1A|UHR -1.93219 0 54 0 0 -4.90339 3.029573 81 Processes 55137|55 F1|DTL|N 183|5521 SMCE4A| 5|63967|8 PARPBP| 0010|801 USP47|FI 19|83933| GN|RIF1|F 84690|91 ANCI|CLS 442|9266 PN|RMI1| 7|119392| PIF1|HDA 146956|2 C10|SPAT 54394|35 A22|FAAP 3497|401 24|MGME 720 1|SFR1|E ME1|MC M9|POLN BUB1|BU 699|701|1 GO B1B|CENP GO:00070 063|7272| 1 -3.74477 M1 1 0 Biological 19 mitotic spindle assembly checkpoint -3.74477 5.696786 5.306703 24156 34 873 7 0.801833 0.301847 F|TTK|TRI -1.93219 0 25 0 0 -7.23866 13.83505 94 9319|104 Processes P13|NDC 03|56155 80|TEX14 BUB1|BU 699|701|1 GO B1B|CENP GO:00315 063|7272| 1 -3.74477 M1 1 0 Biological 19 spindle checkpoint -3.74477 5.696786 5.306703 24156 34 873 7 0.801833 0.301847 F|TTK|TRI -1.93219 0 25 0 0 -7.23866 13.83505 77 9319|104 Processes P13|NDC 03|56155 80|TEX14 BUB1|BU 699|701|1 GO B1B|CENP GO:00711 063|7272| 1 -3.74477 M1 1 0 Biological 19 spindle assembly checkpoint -3.74477 5.696786 5.306703 24156 34 873 7 0.801833 0.301847 F|TTK|TRI -1.93219 0 25 0 0 -7.23866 13.83505 73 9319|104 Processes P13|NDC 03|56155 80|TEX14 BUB1|BU 699|701|1 GO B1B|CENP GO:00711 063|7272| 1 -3.74477 M1 1 0 Biological 19 mitotic spindle checkpoint -3.74477 5.696786 5.306703 24156 34 873 7 0.801833 0.301847 F|TTK|TRI -1.93219 0 25 0 0 -7.23866 13.83505 74 9319|104 Processes P13|NDC 03|56155 80|TEX14 ACTC1|A 70|87|88| CTN1|AC 2275|105 TN2|FHL3 29|11346| |NEBL|SY GO 27063|27 NPO|ANK GO:00316 Cellular 1 -2.73477 M1 1 0 20 I band -2.73477 2.551144 3.57694 24156 141 873 13 1.489118 0.40992 295|2978 RD1|PDLI -1.1667 0 48 0 0 -5.29557 3.217454 74 Compone 0|57159|9 M3|PARV nts 1624|919 B|TRIM54| 77|11314 NEXN|MY 6 OZ3|AHN AK2 BMP7|CO 655|1294| L7A1|CC 1490|220 N2|FBN2| 1|4208|51 MEF2C|P 56|6422|6 DGFRA|SF 935|6939| RP1|ZEB1| 9249|107 TCF15|DH GO 36|25886| GO:00487 RS3|SIX2| 1 -3.74029 M1 1 0 Biological 19 skeletal system morphogenesis -3.74029 2.421134 4.284376 24156 240 873 21 2.405498 0.518571 51141|51 -1.92882 0 11 0 0 -10.1305 3.03234 05 POC1A|I Processes 715|5511 NSIG2|RA 2|55790|1 B23|WDR 16039|15 60|CSGAL 7506|158 NACT1|O 326|3598 SR2|RDH 45|64265 10|FREM1 8 |RFLNB|S GO GO:00355 sequestering of TGFbeta in extracellular 2200|220 FBN1|FBN 1 -3.73731 M1 1 0 Biological 19 -3.73731 20.75258 7.650123 24156 4 873 3 0.343643 0.198061 -1.92882 0 24 0 0 -7.35548 20.75258 83 matrix 1|4052 2|LTBP1 Processes SERPINE2 GO 5270|562 GO:00216 |PROX1|KI 1 -3.73382 M1 1 0 Biological 19 cerebellar granular layer morphogenesis -3.73382 12.29782 6.564107 24156 9 873 4 0.45819 0.22857 9|9928|85 -1.92772 0 92 1 1 -3.73382 12.29782 83 F14|KND Processes 442 C1 BUB1|BU 699|701|1 B1B|CENP GO 063|7272| GO:00519 negative regulation of chromosome F|TTK|PTT 1 -3.73215 M1 1 0 Biological 19 -3.73215 4.919129 5.095413 24156 45 873 8 0.91638 0.322501 9232|931 -1.92772 0 25 0 0 -7.23866 13.83505 85 segregation G1|TRIP1 Processes 9|10403|5 3|NDC80| 6155 TEX14 1003|100 CDH5|CD 5|1007|10 H7|CDH9| GO GO:00443 08|1009|2 CDH10|C 1 -3.73215 M1 1 0 Biological 19 cell-cell adhesion mediated by cadherin -3.73215 4.919129 5.095413 24156 45 873 8 0.91638 0.322501 -1.92772 0 32 0 0 -6.28754 6.917526 31 8984|640 DH11|RG Processes 72|22225 CC|CDH2 6 3|CDHR3 ACTN2|C AMK2A|C 88|815|13 REB1|GRI 85|2890|2 A1|GRIN1 R-HSA- Reactome Activation of NMDA receptors and 902|3838| 1 -2.711 M1 1 0 6 -2.711 2.97528 3.695612 24156 93 873 10 1.145475 0.360151 |KPNA2|P -1.14643 0 164 1 1 -2.711 11.06804 442755 Gene Sets postsynaptic events 5563|228 RKAA2|PP 43|79861| M1E|TUB 81027 AL3|TUBB 1 AGTR2|FA 186|355|6 S|BRCA1|I 72|3624|3 NHBA|LG 958|5366| ALS3|PM 6422|649 AIP1|SFR GO GO:20012 regulation of extrinsic apoptotic signaling 8|7057|70 P1|SKIL|T 1 -3.72524 M1 1 0 Biological 19 -3.72524 2.819883 4.429839 24156 157 873 16 1.832761 0.453972 -1.92182 0 52 0 0 -5.08367 9.88218 36 pathway 78|8743|8 HBS1|TIM Processes 772|1041 P3|TNFSF 3|50486|5 10|FADD| 5023|389 YAP1|G0S 400 2|PHIP|GF RAL ITGB4|LA 3691|390 MA3|LIF| Canonical 9|3976|43 1 -2.70942 M65 M1 1 0 11 PID FRA PATHWAY -2.70942 4.487044 4.110265 24156 37 873 6 0.687285 0.279617 MMP1|NF -1.14601 0 166 1 1 -2.70942 4.487044 Pathways 12|4772|7 ATC1|TH 056 BD BMP7|CO 655|1289| L5A1|COL 1294|129 7A1|COL8 5|2335|36 A1|FN1|I GO 24|3673|3 GO:00017 NHBA|IT 1 -3.7225 M1 1 0 Biological 19 formation of primary germ layer -3.7225 3.074456 4.52068 24156 126 873 14 1.603666 0.425147 690|3691| -1.92009 0 77 0 0 -4.11211 18.44674 04 GA2|ITGB Processes 3909|391 3|ITGB4|L 4|7296|10 AMA3|LA 736|6426 MB3|TXN 58 RD1|SIX2| BUB1|BU 699|701|1 B1B|CENP 062|1063| GO E|CENPF| GO:19020 regulation of metaphase/anaphase 7272|931 1 -3.71837 M1 1 0 Biological 19 -3.71837 4.368964 4.930891 24156 57 873 9 1.030928 0.341867 TTK|TRIP1 -1.91797 0 25 0 0 -7.23866 13.83505 99 transition of cell cycle 9|9787|10 Processes 3|DLGAP5 403|5615 |NDC80|T 5 EX14 ACTN1|C 87|1021|3 DK6|ITGB 690|5420| 3|PODXL| 5795|707 PTPRJ|TIA GO 4|7456|10 M1|WIPF GO:00017 Cellular 324|2608 1|KLHL41| 1 -2.70156 M1 1 0 20 ruffle -2.70156 2.344924 3.477443 24156 177 873 15 1.718213 0.439813 -1.13988 0 76 0 0 -4.21719 2.344924 26 Compone 4|54997|5 ARHGEF2 nts 5785|576 6|TESC|F 08|81930| GD6|JCA 84687|15 D|KIF18A| 2273 PPP1R9B| FGD5 BUB1|BU 699|701|1 B1B|CENP 062|1063| E|CENPF| GO 7272|923 GO:00330 TTK|PTTG 1 -3.71258 M1 1 0 Biological 19 regulation of sister chromatid segregation -3.71258 3.667122 4.713115 24156 83 873 11 1.260023 0.37751 2|9319|97 -1.91517 0 25 0 0 -7.23866 13.83505 45 1|TRIP13| Processes 87|10403| DLGAP5| 10460|56 NDC80|T 155 ACC3|TEX BMP7|ED 655|1908| N3|FN1|H 2335|328 ES1|HTR2 GO 0|3357|49 GO:00140 B|NRTN|P 1 -3.71258 M1 1 0 Biological 19 mesenchymal cell development -3.71258 3.667122 4.713115 24156 83 873 11 1.260023 0.37751 02|5308|8 -1.91517 0 28 0 0 -6.45792 4.716495 31 ITX2|ALD Processes 854|9723| H1A2|SE 30812|15 MA3E|SO 7506 X8|RDH1 BMP7|ED 655|1908| N3|FN1|H 2335|328 ES1|HTR2 GO 0|3357|49 GO:00488 B|NRTN|P 1 -3.71258 M1 1 0 Biological 19 stem cell development -3.71258 3.667122 4.713115 24156 83 873 11 1.260023 0.37751 02|5308|8 -1.91517 0 28 0 0 -6.45792 4.716495 64 ITX2|ALD Processes 854|9723| H1A2|SE 30812|15 MA3E|SO 7506 X8|RDH1 AGTR2|FA S|BRCA1| 186|355|6 CASP2|IN 72|835|36 HBA|LGA 24|3958|5 LS3|PMAI 366|6422| P1|SFRP1| 6498|705 GO SKIL|THBS GO:00971 7|7078|71 1 -3.70727 M1 1 0 Biological 19 extrinsic apoptotic signaling pathway -3.70727 2.470545 4.281579 24156 224 873 20 2.290951 0.50637 1|TIMP3|T -1.91185 0 52 0 0 -5.08367 9.88218 91 32|7133|8 Processes NFRSF1A| 743|8772| TNFRSF1 9812|104 B|TNFSF1 13|50486| 0|FADD|D 55023|38 ELE1|YAP 9400 1|G0S2|P HIP|GFRA ALK|EPHB 238|2047| 1|EPHB2| 2048|232 FLT4|HPX| 4|3263|32 HES1|ITG 80|3690|3 B3|LIF|ME 976|4233| T|NTRK3| 4916|515 PDGFRA| 6|5175|57 PECAM1| 95|6422|6 GO PTPRJ|SF GO:00181 503|7075| 1 -3.6642 M1 1 0 Biological 19 peptidyl-tyrosine phosphorylation -3.6642 2.08831 4.090525 24156 371 873 28 3.207331 0.596329 RP1|SLA|T -1.87271 0 69 0 0 -4.35611 3.891108 08 7132|727 Processes IE1|TNFR 2|7465|87 SF1A|TTK| 67|9833|5 WEE1|RIP 4892|553 K2|MELK| 59|56034| NCAPG2| 91461|28 STYK1|PD 4656|285 GFC|PKD 016|2854 CC|EPHA 89 10|ALKAL ACTC1|A CTN2|SM 70|88|408 AD4|MEF 9|4208|51 2C|PDGF 56|5629|7 GO RA|PROX GO:00109 cellular component assembly involved in 139|7140| 1 -3.64822 M1 1 0 Biological 19 -3.64822 3.183286 4.504502 24156 113 873 13 1.489118 0.40992 1|TNNT2| -1.85966 0 13 0 0 -9.83559 6.28866 27 morphogenesis 10324|10 Processes TNNT3|KL 529|2706 HL41|NEB 3|29766|5 L|ANKRD 7082 1|TMOD3 |KNL1 BRCA1|C 672|947|1 D34|CDH 003|1545| 5|CYP1B1 1870|224 |E2F2|FGF 7|2277|52 2|VEGFD| 28|5587|6 PGF|PRK 422|6915| D1|SFRP1 7057|705 |TBXA2R| 8|7075|78 THBS1|TH GO 52|9723|1 BS2|TIE1| GO:00457 1 -3.62715 M1 1 0 Biological 19 regulation of angiogenesis -3.62715 2.047023 4.046976 24156 392 873 29 3.321879 0.606525 0266|105 CXCR4|SE -1.84053 0 15 0 0 -9.08083 2.73285 65 Processes 16|23213| MA3E|RA 28984|51 MP2|FBL 129|5456 N5|SULF1 7|57381|5 |RGCC|A 7608|641 NGPTL4| 02|79812| DLL4|RH 147372|6 OJ|JCAD| 41700|72 TNMD|M 9230 MRN2|CC BE1|ECSC 1894|905 ECT2|PST GO 1|10733|5 PIP1|PLK4 GO:00321 Cellular 4443|548 |ANLN|N 1 -2.68133 M1 1 0 20 cell division site part -2.68133 3.458763 3.81383 24156 64 873 8 0.91638 0.322501 -1.12425 0 168 1 1 -2.68133 3.458763 55 Compone 20|55165| DE1|CEP5 nts 83872|84 5|HMCN1 930 |MASTL ADORA2 135|794|1 A|CALB2| 385|1395| CREB1|CR GO 2048|527 HR2|EPH GO:00602 1 -3.61982 M1 1 0 Biological 19 long-term synaptic potentiation -3.61982 3.580837 4.615451 24156 85 873 11 1.260023 0.37751 0|10590|2 B2|SERPI -1.83417 0 49 0 0 -5.27843 3.609144 91 Processes 2871|232 NE2|SCG 37|57616| N|NLGN1 347730 |ARC|TSH Z3|LRRT CAMK2A| 815|894|2 CCND2|G 239|2535| PC4|FZD2 4089|431 |SMAD4| KEGG 6|4772|64 MMP7|NF 1 -2.68015 hsa04310 M1 1 0 24 Wnt signaling pathway -2.68015 2.515464 3.519505 24156 143 873 13 1.489118 0.40992 -1.12421 0 169 1 1 -2.68015 3.353952 Pathway 22|6425|8 ATC1|SFR 325|2712 P1|SFRP5| 3|80326|1 FZD8|DKK 44165 2|WNT10 A|PRICKL PRDM1|B 639|655|2 MP7|FZD 535|3280| 2|HES1|LT 4052|408 BP1|SMA GO GO:00032 9|5125|56 D4|PCSK5 1 -3.60998 M1 1 0 Biological 19 cardiac septum development -3.60998 3.155363 4.466616 24156 114 873 13 1.489118 0.40992 -1.82626 0 75 0 0 -4.23321 3.816566 79 29|8543|9 |PROX1|L Processes 249|1045 MO4|DH 4|11174|2 RS3|TAB1 3414 |ADAMTS 6|ZFPM2 ALK|EPHB 238|2047| 1|EPHB2| 2048|232 FLT4|HPX| 4|3263|32 HES1|ITG 80|3690|3 B3|LIF|ME 976|4233| T|NTRK3| 4916|515 PDGFRA| 6|5175|57 PECAM1| 95|6422|6 GO PTPRJ|SF GO:00182 503|7075| 1 -3.60692 M1 1 0 Biological 19 peptidyl-tyrosine modification -3.60692 2.071559 4.04407 24156 374 873 28 3.207331 0.596329 RP1|SLA|T -1.82416 0 69 0 0 -4.35611 3.891108 12 7132|727 Processes IE1|TNFR 2|7465|87 SF1A|TTK| 67|9833|5 WEE1|RIP 4892|553 K2|MELK| 59|56034| NCAPG2| 91461|28 STYK1|PD 4656|285 GFC|PKD 016|2854 CC|EPHA 89 10|ALKAL 655|753|1 BMP7|LD 021|1289| LRAD4|C 1600|204 DK6|COL 7|2048|21 5A1|DAB 03|2200|3 1|EPHB1| 280|3624| EPHB2|ES 3690|408 RRB|FBN1 9|4772|49 |HES1|IN 16|4974|5 HBA|ITGB 167|5744| 3|SMAD4| 6095|642 NFATC1| 2|6498|69 NTRK3|O 35|8111|9 MG|ENPP GO 423|9547| 1|PTHLH| GO:00455 1 -3.59267 M1 1 0 Biological 19 negative regulation of cell differentiation -3.59267 1.713432 3.867092 24156 759 873 47 5.383734 0.763867 9723|104 RORA|SF -1.81087 0 98 1 1 -3.59267 1.713432 96 Processes 13|10468| RP1|SKIL| 10631|10 ZEB1|GPR 736|2287 68|NTN1| 1|23414|3 CXCL14|S 0812|548 EMA3E|Y 92|56963| AP1|FST|P 57540|93 OSTN|SIX 649|1175 2|NLGN1| 81|14416 ZFPM2|S 5|148979| OX8|NCA 157285|2 PG2|RGM 02151|20 A|DISP3| 5717|259 MYOCD|T 266|2842 WIST2|PR 1240|284 CMKLR1| GO GO:00016 G protein-coupled chemoattractant 0|7852|51 GPR17|CX 1 -2.67161 M1 1 0 Molecular 21 -2.67161 5.321174 4.268752 24156 26 873 5 0.572738 0.255402 -1.11956 0 93 0 0 -3.70842 5.321174 37 receptor activity 554|7292 CR4|ACK Functions 30 R4|CCR2 1240|284 CMKLR1| GO GO:00049 0|7852|51 GPR17|CX 1 -2.67161 M1 1 0 Molecular 21 chemokine receptor activity -2.67161 5.321174 4.268752 24156 26 873 5 0.572738 0.255402 -1.11956 0 93 0 0 -3.70842 5.321174 50 554|7292 CR4|ACK Functions 30 R4|CCR2 BUB1|BU 699|701|1 GO B1B|CENP GO:00458 negative regulation of mitotic 063|7272| 1 -3.58125 M1 1 0 Biological 19 -3.58125 5.380298 5.092809 24156 36 873 7 0.801833 0.301847 F|TTK|TRI -1.80209 0 25 0 0 -7.23866 13.83505 41 metaphase/anaphase transition 9319|104 Processes P13|NDC 03|56155 80|TEX14 10051|10 SMC4|SM GO GO:00070 592|2339 C2|NCAP 1 -3.58101 M1 1 0 Biological 19 mitotic chromosome condensation -3.58101 8.138266 5.700969 24156 17 873 5 0.572738 0.255402 -1.80209 0 36 0 0 -6.06241 22.13608 76 7|51203|6 H|NUSAP Processes 4151 1|NCAPG ADORA2 A|ASPA|C 135|443|9 DK1|CDK 83|1021|1 6|CREB1| 385|1600| DAB1|GP 2840|328 R17|HES1 0|3976|49 |LIF|NTRK 16|5179|5 3|PENK|S GO 270|5354| GO:00420 ERPINE2| 1 -3.57132 M1 1 0 Biological 19 gliogenesis -3.57132 2.206254 4.077777 24156 301 873 24 2.749141 0.553399 6692|707 -1.79334 0 56 0 0 -4.84716 6.385408 63 PLP1|SPI Processes 4|7133|72 NT1|TIAM 23|7852|8 1|TNFRSF 726|3081 1B|TRPC4 2|57165|8 |CXCR4|E 3933|854 ED|SOX8| 14|72923 GJC2|HD 0 AC10|SLC 45A3|CCR BRCA1|B 672|699|7 UB1|BUB1 01|1063|1 B|CENPF| 789|7153| DNMT3B| GO 7272|752 TOP2A|TT GO:20012 negative regulation of chromosome 1 -3.53533 M1 1 0 Biological 19 -3.53533 2.82348 4.294017 24156 147 873 15 1.718213 0.439813 0|9232|93 K|XRCC5| -1.76208 0 25 0 0 -7.23866 13.83505 51 organization Processes 19|10403| PTTG1|TR 54464|56 IP13|NDC 155|8011 80|XRN1| 9|80169 TEX14|PIF 1|CTC1 ACTC1|A CTN2|AD ORA2B|C 70|88|136 HRM3|CH |1131|113 RNA1|CC 4|1490|19 N2|EDN2| 07|1908|3 EDN3|HT 357|3672| R2B|ITGA 3673|375 1|ITGA2|K 9|3762|40 GO CNJ2|KC GO:00069 90|4632|6 1 -3.53093 M1 1 0 Biological 19 muscle contraction -3.53093 2.081038 3.995935 24156 359 873 27 3.092784 0.58593 NJ5|SMA -1.75862 0 61 0 0 -4.53228 18.44674 36 869|6915| Processes D5|MYL1| 7135|713 TACR1|TB 6|7139|71 XA2R|TN 40|7852|9 NI1|TNNI 312|1032 2|TNNT2| 4|23213|2 TNNT3|C 9766|936 XCR4|KC 49 NB2|KLHL 41|SULF1| TMOD3| 1063|746 CENPF|W R-HSA- Reactome 1 -2.66202 M1 1 0 6 Polo-like kinase mediated events -2.66202 6.917526 4.584824 24156 16 873 4 0.45819 0.22857 5|9133|28 EE1|CCNB -1.11455 0 110 0 0 -3.35124 18.44674 156711 Gene Sets 6826 2|LIN9 GO 1063|679 CENPF|A GO:00451 Cellular 1 -2.66202 M1 1 0 20 pronucleus -2.66202 6.917526 4.584824 24156 16 873 4 0.45819 0.22857 0|8726|55 URKA|EE -1.11455 0 170 1 1 -2.66202 6.917526 20 Compone 183 D|RIF1 nts ADORA2 R-HSA- Reactome 135|136|2 A|ADORA 1 -2.66202 M1 1 0 6 Nucleotide-like (purinergic) receptors -2.66202 6.917526 4.584824 24156 16 873 4 0.45819 0.22857 -1.11455 0 171 1 1 -2.66202 13.83505 418038 Gene Sets 840|2846 2B|GPR17 |LPAR4 TIMP3|TI GO 7078|707 GO:00081 MP4|WFI 1 -2.66202 M1 1 0 Molecular 21 metalloendopeptidase inhibitor activity -2.66202 6.917526 4.584824 24156 16 873 4 0.45819 0.22857 9|117166| -1.11455 0 172 1 1 -2.66202 6.917526 91 KKN1|WFI Functions 124857 KKN2 CRABP1| GO 1381|138 GO:00169 CRABP2|R 1 -2.66202 M1 1 0 Molecular 21 retinal binding -2.66202 6.917526 4.584824 24156 16 873 4 0.45819 0.22857 2|6017|88 -1.11455 0 173 1 1 -2.66202 6.917526 18 LBP1|ALD Functions 54 H1A2 BUB1|BU GO 699|701|8 GO:00071 B1B|MAS 1 -3.52458 M1 1 0 Biological 19 meiosis II -3.52458 11.06804 6.166143 24156 10 873 4 0.45819 0.22857 4930|150 -1.756 0 25 0 0 -7.23866 13.83505 35 TL|HORM Processes 280 AD2 BUB1|BU GO 699|701|8 GO:00619 B1B|MAS 1 -3.52458 M1 1 0 Biological 19 meiosis II cell cycle process -3.52458 11.06804 6.166143 24156 10 873 4 0.45819 0.22857 4930|150 -1.756 0 25 0 0 -7.23866 13.83505 83 TL|HORM Processes 280 AD2 BUB1|BU 699|701|1 GO B1B|CENP GO:19021 negative regulation of 063|7272| 1 -3.5038 M1 1 0 Biological 19 -3.5038 5.234884 4.991763 24156 37 873 7 0.801833 0.301847 F|TTK|TRI -1.738 0 25 0 0 -7.23866 13.83505 00 metaphase/anaphase transition of cell cycle 9319|104 Processes P13|NDC 03|56155 80|TEX14 CRHBP|H 1393|301 2AZ1|ITG GO 5|3673|64 GO:00713 A2|SFRP1| 1 -3.5038 M1 1 0 Biological 19 cellular response to estradiol stimulus -3.5038 5.234884 4.991763 24156 37 873 7 0.801833 0.301847 22|10891| -1.738 0 87 0 0 -3.8385 5.234884 92 PPARGC1 Processes 81930|84 A|KIF18A| 687 PPP1R9B BARD1|B RCA1|BR 580|672|6 CA2|CAS 75|835|98 P2|CDK1| 3|1870|30 E2F2|HIC 90|4361|5 1|MRE11| 366|5563| PMAIP1|P GO 5600|593 GO:00723 RKAA2|M 1 -3.49696 M1 1 0 Biological 19 signal transduction by p53 class mediator -3.49696 2.271426 4.052844 24156 268 873 22 2.520046 0.530463 1|6790|70 -1.73209 0 101 1 1 -3.49696 2.706858 31 APK11|RB Processes 29|9156|2 BP7|AURK 2974|270 A|TFDP2| 63|28984| EXO1|TPX 51512|55 2|ANKRD 003|8001 1|RGCC|G 0|144455 TSE1|PAK 1IP1|RMI ACTN2|B RCA1|CC 88|672|14 N2|DNMT 90|1789|1 3B|EDN3| 908|3976| LIF|SMAD 4089|423 4|MET|M 3|4361|47 RE11|NEK 51|4916|5 2|NTRK3| 073|5081| PARN|PA 5366|558 X7|PMAIP 7|5629|64 1|PRKD1| 22|6790|7 PROX1|SF 029|7456| RP1|AUR 7520|872 GO KA|TFDP2 GO:00106 positive regulation of organelle 6|8743|96 1 -3.48904 M1 1 0 Biological 19 -3.48904 1.769851 3.8252 24156 641 873 41 4.696449 0.716032 |WIPF1|X -1.72692 0 14 0 0 -9.68163 3.166231 38 organization 62|9787|1 Processes RCC5|EED 0733|107 |TNFSF10| 88|10891| CEP135|D 11346|22 LGAP5|PL 843|2299 K4|IQGAP 8|25886|2 2|PPARG 8984|512 C1A|SYN 03|55023| PO|PPM1 55183|55 E|LIMCH1 196|5583 |POC1A|R 5|85459|9 GCC|NUS 0427|100 AP1|PHIP| 506658 RIF1|RESF 1|CENPJ| THBS1|TH BS2|ADA 7057|705 MTS3|AD 8|9508|97 AMTSL2| 19|11174| ADAMTS R-HSA- Reactome 54437|55 1 -2.64117 M1 1 0 6 O-linked glycosylation -2.64117 2.742082 3.562123 24156 111 873 11 1.260023 0.37751 6|SEMA5 -1.10264 0 33 0 0 -6.2858 7.478406 5173105 Gene Sets 901|5718 B|THSD1| 8|80731|9 ADAMTS 3010|170 L3|THSD7 692 B|B3GNT 7|ADAMT GO COL4A5| GO:00986 Cellular 1287|128 1 -2.63853 M1 1 0 20 network-forming collagen trimer -2.63853 10.37629 5.136018 24156 8 873 3 0.343643 0.198061 COL4A6| -1.10264 0 5 0 0 -15.2617 12.29782 42 Compone 8|1295 COL8A1 nts GO COL4A5| GO:00986 Cellular 1287|128 1 -2.63853 M1 1 0 20 collagen network -2.63853 10.37629 5.136018 24156 8 873 3 0.343643 0.198061 COL4A6| -1.10264 0 5 0 0 -15.2617 12.29782 45 Compone 8|1295 COL8A1 nts PRDM1|B MP7|BRC 639|655|6 A2|CASP2 75|835|89 |CCNF|CO 9|1299|21 L9A3|ESR 03|2620|3 RB|GAS2| 280|3624| HES1|INH 3976|408 BA|LIF|SM 9|5156|52 AD4|PDG 70|6422|6 FRA|SERP 692|7022| GO INE2|SFR GO:00486 8743|104 1 -3.48196 M1 1 0 Biological 19 reproductive structure development -3.48196 1.953925 3.905781 24156 439 873 31 3.550974 0.626348 P1|SPINT -1.72077 0 89 0 0 -3.75072 2.95506 08 68|10733| Processes 1|TFAP2C 23213|23 |TNFSF10| 414|2359 FST|PLK4| 8|30812|5 SULF1|ZF 1294|819 PM2|PAT 30|93649| Z1|SOX8| 144455|1 PCDH12| 57506|25 KIF18A|M 9266|642 YOCD|E2 658 F7|RDH10 |ASPM|SC BMP7|CD 655|983|1 K1|COL5 289|2535| A1|FZD2| 3280|390 HES1|LA GO 9|4155|64 GO:00459 MA3|MBP 1 -3.4768 M1 1 0 Biological 19 regulation of embryonic development -3.4768 2.912642 4.282892 24156 133 873 14 1.603666 0.425147 22|9096|2 -1.71651 0 103 1 1 -3.4768 2.912642 95 |SFRP1|TB Processes 3213|126 X18|SULF 731|2842 1|CCSAP| 17|44147 LAMA1|N 8|642658 RARP|SCX 1062|992 CENPE|KI 8|10403|1 F14|NDC GO GO:00070 1004|551 80|KIF2C| 1 -3.46684 M1 1 0 Biological 19 mitotic metaphase plate congression -3.46684 4.517568 4.772656 24156 49 873 8 0.91638 0.322501 -1.70928 0 2 0 0 -22.074 10.54099 80 65|79003| CEP55|MI Processes 81930|83 S12|KIF18 540 A|NUF2 ACTL6A|A 86|186|98 GTR2|CD 3|1382|13 K1|CRABP 85|2247|2 2|CREB1|F 273|2307| GF2|FHL1 2335|280 |FOXS1|F 3|3624|40 N1|GOLG 89|4208|4 A4|INHBA 886|4916| |SMAD4| 5167|527 MEF2C|N 0|5600|56 PY1R|NTR 29|5795|5 K3|ENPP1 931|6387| |SERPINE GO 6422|709 2|MAPK1 GO:00400 1 -3.44559 M1 1 0 Biological 19 regulation of growth -3.44559 1.734423 3.778707 24156 686 873 43 4.925544 0.732406 3|7852|91 1|PROX1| -1.69254 0 104 1 1 -3.44559 2.082696 08 Processes 33|9423|9 PTPRJ|RB 723|9928| BP7|CXCL 10276|10 12|SFRP1| 413|1051 TLL2|CXC 6|23414|2 R4|CCNB 6153|299 2|NTN1|S 48|55031| EMA3E|KI 55257|84 F14|NET1| 312|8468 YAP1|FBL 7|85004|9 N5|ZFPM 3649|151 2|KIF26A| 835|2197 OSGIN1| 70 USP47|M RGBP|BR BARD1|B CORUM:2 BRCA1-BARD1-BACH1-DNA damage 580|672|4 1 -2.63853 M1 1 0 CORUM 33 -2.63853 10.37629 5.136018 24156 8 873 3 0.343643 0.198061 RCA1|MR -1.10264 0 70 0 0 -4.32747 27.6701 815 complex II 361 E11 R-HSA- Reactome 4060|496 LUM|OG 1 -2.63853 M1 1 0 6 Defective CHST6 causes MCDC1 -2.63853 10.37629 5.136018 24156 8 873 3 0.343643 0.198061 -1.10264 0 96 0 0 -3.66151 10.37629 3656225 Gene Sets 9|11081 N|KERA

R-HSA- Reactome Defective ST3GAL3 causes MCT12 and 4060|496 LUM|OG 1 -2.63853 M1 1 0 6 -2.63853 10.37629 5.136018 24156 8 873 3 0.343643 0.198061 -1.10264 0 96 0 0 -3.66151 10.37629 3656243 Gene Sets EIEE15 9|11081 N|KERA

R-HSA- Reactome Defective B4GALT1 causes B4GALT1-CDG 4060|496 LUM|OG 1 -2.63853 M1 1 0 6 -2.63853 10.37629 5.136018 24156 8 873 3 0.343643 0.198061 -1.10264 0 96 0 0 -3.66151 10.37629 3656244 Gene Sets (CDG-2d) 9|11081 N|KERA ACTN2|C 88|983|47 DK1|NEK 51|5116|5 2|PCNT|P 420|5992| ODXL|RF 8655|942 X4|DYNLL 3|9662|97 1|NTN1|C 12|9814|1 EP135|US 0324|107 P6NL|SFI1 33|22871| |KLHL41|P 23216|23 LK4|NLG 433|2588 N1|TBC1 6|26084|2 D1|RHOQ 9780|510 |POC1A|A 98|51715| GO RHGEF26| GO:00300 54443|54 1 -3.44146 M1 1 0 Biological 19 cell projection assembly -3.44146 1.789609 3.802232 24156 603 873 39 4.467354 0.699188 PARVB|IF -1.69004 0 12 0 0 -10.0997 6.06468 31 820|5511 Processes T52|RAB2 2|55125|5 3|ANLN|N 5785|558 DE1|WDR 35|57381| 60|CEP19 79441|80 2|FGD6|C 184|8468 ENPJ|RH 7|117178| OJ|HAUS 121441|1 3|CEP290| 52273|16 PPP1R9B| 1582|196 SSX2IP|N 527|3398 EDD1|FG 29|34724 D5|DNAA 0|100506 F4|ANO6| 658 CCDC39| R-HSA- Reactome 2277|232 VEGFD|FL 1 -2.63853 M1 1 0 6 VEGF ligand-receptor interactions -2.63853 10.37629 5.136018 24156 8 873 3 0.343643 0.198061 -1.10264 0 137 0 0 -3.04056 10.37629 194313 Gene Sets 4|5228 T4|PGF

R-HSA- Reactome VEGF binds to VEGFR leading to receptor 2277|232 VEGFD|FL 1 -2.63853 M1 1 0 6 -2.63853 10.37629 5.136018 24156 8 873 3 0.343643 0.198061 -1.10264 0 137 0 0 -3.04056 10.37629 195399 Gene Sets dimerization 4|5228 T4|PGF GO 11104|55 KATNA1| GO:00085 1 -2.63853 M1 1 0 Molecular 21 microtubule-severing ATPase activity -2.63853 10.37629 5.136018 24156 8 873 3 0.343643 0.198061 137|4017 FIGN|FIG -1.10264 0 175 1 1 -2.63853 10.37629 68 Functions 20 NL2 XIAP|FAS| 331|355|2 EPHB2|M 048|4214| Canonical AP3K1|M 1 -2.63799 M8873 M1 1 0 11 ST FAS SIGNALING PATHWAY -2.63799 3.405551 3.760409 24156 65 873 8 0.91638 0.322501 4233|578 -1.10264 0 141 0 0 -2.97821 18.44674 Pathways ET|PTPN1 3|8772|22 3|FADD|T 974 PX2 BMP7|FZ 655|2535| D2|PODX 5420|562 L|PROX1| 9|6422|64 SFRP1|STI 91|6692|8 L|SPINT1| GO GO:00351 543|9585| LMO4|KIF 1 -3.44041 M1 1 0 Biological 19 tube formation -3.44041 2.76701 4.203548 24156 150 873 15 1.718213 0.439813 -1.69004 0 64 0 0 -4.46525 3.120688 48 30812|51 20B|SOX8 Processes 098|5761 |IFT52|SH 9|80184|1 ROOM3| 31405|14 CEP290|T 4165 RIM71|PR ICKLE1 2047|217 EPHB1|FA 3|5629|60 BP7|PRO 95|6692|9 X1|RORA| 833|9928| SPINT1|M GO 54567|54 ELK|KIF14 GO:00613 1 -3.44041 M1 1 0 Biological 19 neural precursor cell proliferation -3.44041 2.76701 4.203548 24156 150 873 15 1.718213 0.439813 820|5716 |DLL4|ND -1.69004 0 105 1 1 -3.44041 3.074456 51 Processes 5|57540|5 E1|GJC2| 7650|131 DISP3|CIP 405|2592 2A|TRIM7 66|40773 1|ASPM|T 8 AFA1 672|6491| BRCA1|ST GO 9662|107 IL|CEP135 GO:00070 1 -3.429 M1 1 0 Biological 19 centriole replication -3.429 5.097124 4.89431 24156 38 873 7 0.801833 0.301847 33|55835| |PLK4|CE -1.68042 0 19 0 0 -7.81934 13.83505 99 Processes 56890|85 NPJ|MDM 459 1|CEP295 4175|499 MCM6|O GO 8|4999|55 RC1|ORC GO:00062 1 -3.429 M1 1 0 Biological 19 DNA replication initiation -3.429 5.097124 4.89431 24156 38 873 7 0.801833 0.301847 58|8318|9 2|PRIM2| -1.68042 0 20 0 0 -7.69554 7.546392 70 Processes 134|5538 CDC45|C 8 CNE2|MC ACTN2|C AMK2A|C 88|815|13 REB1|GRI 85|2890|2 R-HSA- Reactome A1|GRIN1 1 -2.62714 M1 1 0 6 Post NMDA receptor activation events -2.62714 3.112887 3.66539 24156 80 873 9 1.030928 0.341867 902|3838| -1.09479 0 164 0 0 -2.711 11.06804 438064 Gene Sets |KPNA2|P 5563|798 RKAA2|T 61|81027 UBAL3|TU BB1 ALK|BMP 238|655|1 7|CRABP2 382|1600| |DAB1|DN 1789|189 MT3B|EC 4|2048|23 T2|EPHB2 35|2803|2 |FN1|GOL 902|3280| GA4|GRI 3706|420 N1|HES1|I 8|4610|49 TPKA|ME 16|4974|5 F2C|MYC 121|5587| L|NTRK3| 5629|638 OMG|PCP 7|6422|64 4|PRKD1| GO 98|6935|7 PROX1|C GO:00456 1 -3.4194 M1 1 0 Biological 19 regulation of neuron differentiation -3.4194 1.742345 3.764678 24156 667 873 42 4.810997 0.724275 074|7852| XCL12|SF -1.6717 0 29 0 0 -6.42481 3.074456 64 Processes 9423|972 RP1|SKIL| 3|11141|2 ZEB1|TIA 2871|232 M1|CXCR 37|26037| 4|NTN1|S 27063|30 EMA3E|IL 812|5696 1RAPL1|N 3|57540|8 LGN1|AR 5442|151 C|SIPA1L 835|1572 1|ANKRD 85|25926 1|SOX8|R 6|285016| GMA|DIS 339479|3 P3|KNDC 75567 1|CPNE9| PRAG1|A 135|186|6 ADORA2 55|675|10 A|AGTR2| 03|1021|1 BMP7|BR 030|1312| CA2|CDH 1545|180 5|CDK6|C 5|2047|21 DKN2B|C 73|3280|3 OMT|CYP 624|3664| 1B1|DPT| 3672|397 EPHB1|FA 6|4089|42 BP7|HES1 08|4883|4 |INHBA|IR 969|5169| F6|ITGA1| 5270|560 LIF|SMAD GO 0|5629|57 4|MEF2C| GO:00082 1 -3.41692 M1 1 0 Biological 19 negative regulation of cell proliferation -3.41692 1.6824 3.733959 24156 773 873 47 5.383734 0.763867 44|5795|6 NPR3|OG -1.67011 0 106 1 1 -3.41692 1.941762 85 Processes 422|6425| N|ENPP3| 6692|693 SERPINE2 5|7057|88 |MAPK11| 54|9104|1 PROX1|PT 0891|232 HLH|PTPR 13|27085| J|SFRP1|S 28984|51 FRP5|SPI 098|5456 NT1|ZEB1 7|54997|5 |THBS1|A 5214|641 LDH1A2| 02|79679| RGN|PPA 85004|93 RGC1A|S 649|1444 ULF1|MT 55 BP|RGCC| AGTR2|B 186|655|2 MP7|FGF 247|4089| 2|SMAD4| 4233|522 MET|PGF| 8|9723|10 GO SEMA3E| GO:00487 branching morphogenesis of an epithelial 413|1073 1 -3.40941 M1 1 0 Biological 19 -3.40941 2.748686 4.173886 24156 151 873 15 1.718213 0.439813 YAP1|SIX -1.66524 0 10 0 0 -10.1376 3.952872 54 tube 6|30812|5 Processes 2|SOX8|D 4567|157 LL4|RDH1 506|2842 0|LAMA1| 17|34041 RSPO2|N 9|441478 RARP 655|2201| BMP7|FB 2824|420 N2|GPM6 GO 8|5167|56 B|MEF2C| GO:00305 1 -3.40021 M1 1 0 Biological 19 regulation of bone mineralization -3.40021 3.640803 4.464838 24156 76 873 10 1.145475 0.360151 172|9146 ENPP1|A -1.65692 0 65 0 0 -4.41834 4.966429 00 Processes 1|116039| NKH|PKD 196527|3 CC|OSR2| 59845 ANO6|RF AGTR2|C 186|1240| MKLR1|G 2840|416 PR17|MC 1|4883|48 5R|NPR3| GO 86|6869|7 GO:00085 NPY1R|T 1 -2.60044 M1 1 0 Molecular 21 G protein-coupled peptide receptor activity -2.60044 2.463776 3.435154 24156 146 873 13 1.489118 0.40992 852|1026 -1.0705 0 94 0 0 -3.67332 2.548562 28 ACR1|CX Functions 6|51554|5 CR4|RAM 7537|114 P2|ACKR4 815|7292 |SORCS2| 30 SORCS1| GO TNNI1|TN 7135|713 GO:00363 Cellular NI2|TNNT 1 -2.59562 M1 1 0 20 myofilament -2.59562 5.124093 4.151756 24156 27 873 5 0.572738 0.255402 6|7139|71 -1.06989 0 61 0 0 -4.53228 18.44674 79 Compone 2|TNNT3| 40|29766 nts TMOD3 CDK1|TFD 983|7029| R-HSA- Reactome P2|TOP2 1 -2.59562 M1 1 0 6 G0 and Early G1 -2.59562 5.124093 4.151756 24156 27 873 5 0.572738 0.255402 7153|913 -1.06989 0 109 0 0 -3.37978 5.929308 1538133 Gene Sets A|CCNE2| 4|286826 LIN9 1490|369 CCN2|ITG GO GO:00019 0|7057|13 B3|THBS1 1 -2.59562 M1 1 0 Molecular 21 fibronectin binding -2.59562 5.124093 4.151756 24156 27 873 5 0.572738 0.255402 -1.06989 0 111 0 0 -3.35124 18.44674 68 1578|151 |LRRC15| Functions 887 CCDC80 BRCA2|EC 675|1894| T2|ESRRB| 2103|224 FGF2|VEG 7|2277|33 FD|HTR2B 57|5228|6 GO |PGF|AUR GO:00513 790|9493| 1 -3.39089 M1 1 0 Biological 19 regulation of cell division -3.39089 2.635248 4.118437 24156 168 873 16 1.832761 0.453972 KA|KIF23| -1.65023 0 102 0 0 -3.49473 18.44674 02 9585|992 Processes KIF20B|KI 8|10733|5 F14|PLK4| 6034|561 PDGFC|TE 55|14445 X14|E2F7| 5|259266 ASPM CENPE|CE 1062|106 NPF|KIF1 3|9928|10 GO 4|NDC80| GO:00513 403|1100 1 -3.38207 M1 1 0 Biological 19 metaphase plate congression -3.38207 3.952872 4.544233 24156 63 873 9 1.030928 0.341867 KIF2C|CE -1.64227 0 2 0 0 -22.074 10.54099 10 4|55165|7 Processes P55|MIS1 9003|819 2|KIF18A| 30|83540 NUF2 AHR|CRE GO 196|1385| GO:00012 B1|SMAD 1 -2.59562 M1 1 0 Molecular 21 transcription coactivator binding -2.59562 5.124093 4.151756 24156 27 873 5 0.572738 0.255402 4089|477 -1.06989 0 178 1 1 -2.59562 18.44674 23 4|NFATC1 Functions 2|6095 |RORA ACTN1|A 87|135|94 DORA2A| 7|954|983 CD34|EN |1289|149 TPD2|CD 0|1816|20 K1|COL5 48|2157|2 A1|CCN2| 247|2335| DRD5|EP 2814|362 HB2|F8|F 4|3673|36 GF2|FN1| 90|3691|4 GP5|INHB 916|5081| A|ITGA2|I 5156|517 TGB3|ITG 5|5270|67 B4|NTRK3 90|6915|7 GO |PAX7|PD GO:00096 056|7057| 1 -3.3802 M1 1 0 Biological 19 response to wounding -3.3802 1.721873 3.728043 24156 691 873 43 4.925544 0.732406 GFRA|PEC -1.64173 0 108 1 1 -3.3802 5.825285 11 7852|798 Processes AM1|SER 0|8357|10 PINE2|AU 413|1063 RKA|TBXA 1|23414|5 2R|THBD| 0808|569 THBS1|CX 63|94121| CR4|TFPI2 113146|1 |H3C10|Y 39189|17 AP1|POST 0692|196 N|ZFPM2| 527|2197 AK3|RGM 70|65360 A|SYTL4|A 4|729230| HNAK2|D 10050665 GKK|ADA 8 MTS18|A ALDH1A3 220|655|5 |BMP7|PR GO GO:00310 629|6935| OX1|ZEB1 1 -3.35671 M1 1 0 Biological 19 embryonic camera-type eye development -3.35671 4.966429 4.800224 24156 39 873 7 0.801833 0.301847 -1.62347 0 7 0 0 -11.4306 6.148912 76 7054|885 |TH|ALDH Processes 4|157506 1A2|RDH 10 SLC25A4| XIAP|BUB 1B|CCND 291|331|7 2|CDKN2 01|894|10 B|CREB1| 30|1385|1 E2F2|FZD 870|2535| 2|SMAD4| 4089|421 KEGG MAP3K1| 1 -2.59355 hsa05166 M1 1 0 24 HTLV-I infection -2.59355 2.05364 3.281744 24156 256 873 19 2.176403 0.493838 4|4603|47 -1.06894 0 180 1 1 -2.59355 2.05364 Pathway MYBL1|N 72|5156|7 FATC1|PD 132|8325| GFRA|TN 9133|923 FRSF1A|F 2|22800|8 ZD8|CCN 0326 B2|PTTG1 |RRAS2|W NT10A XIAP|CAS 331|835|2 P2|GAS2| Canonical 620|4001| LMNB1|M 1 -2.59355 M220 M1 1 0 11 PID CASPASE PATHWAY -2.59355 3.724822 3.808784 24156 52 873 7 0.801833 0.301847 -1.06894 0 181 1 1 -2.59355 11.06804 Pathways 4214|713 AP3K1|TN 2|84823 FRSF1A|L MNB2 ACTC1|A 70|88|463 CTN2|MY GO GO:00300 2|7135|71 L1|TNNI1| 1 -3.35671 M1 1 0 Biological 19 muscle filament sliding -3.35671 4.966429 4.800224 24156 39 873 7 0.801833 0.301847 -1.62347 0 61 0 0 -4.53228 18.44674 49 36|7139|7 TNNI2|TN Processes 140 NT2|TNN T3 BARD1|B 580|672|6 RCA1|BR R-HSA- Reactome Presynaptic phase of homologous DNA 75|4361|9 1 -2.58878 M1 1 0 6 -2.58878 4.256939 3.94159 24156 39 873 6 0.687285 0.279617 CA2|MRE -1.06523 0 70 0 0 -4.32747 27.6701 5693616 Gene Sets pairing and strand exchange 156|8001 11|EXO1| 0 RMI1 ACTC1|A 70|88|463 CTN2|MY GO GO:00332 2|7135|71 L1|TNNI1| 1 -3.35671 M1 1 0 Biological 19 actin-myosin filament sliding -3.35671 4.966429 4.800224 24156 39 873 7 0.801833 0.301847 -1.62347 0 61 0 0 -4.53228 18.44674 75 36|7139|7 TNNI2|TN Processes 140 NT2|TNN T3 655|2201| BMP7|FB GO 2824|420 N2|GPM6 GO:00305 1 -3.35671 M1 1 0 Biological 19 positive regulation of bone mineralization -3.35671 4.966429 4.800224 24156 39 873 7 0.801833 0.301847 8|91461|1 B|MEF2C| -1.62347 0 65 0 0 -4.41834 4.966429 01 Processes 16039|19 PKDCC|O 6527 SR2|ANO PRDM1|D 639|1789| NMT3B|H 3090|328 IC1|HES1| GO 0|3838|42 KPNA2|M GO:00428 1 -2.57992 M1 1 0 Molecular 21 histone deacetylase binding -2.57992 2.69355 3.49409 24156 113 873 11 1.260023 0.37751 08|7153|2 EF2C|TOP -1.05795 0 182 1 1 -2.57992 2.69355 26 Functions 7063|839 2A|ANKR 33|84312| D1|HDAC 93649 10|BRMS 1L|MYOC CENPE|KI 1062|383 F11|KIF23 2|9493|95 |KIF20B|KI 85|9928|1 GO F14|KIF2C GO:00037 1004|241 1 -2.57071 M1 1 0 Molecular 21 motor activity -2.57071 2.554163 3.440478 24156 130 873 12 1.37457 0.394068 |KIF4A|KIF -1.04927 0 46 0 0 -5.44351 7.281606 74 37|26153| Functions 26A|MYO 53904|81 3A|KIF18 930|8495 A|CGNL1| 2|347240 KIF24 ACTC1|A CTN2|AG 70|88|186 TR2|CDK1 |983|3280 |HES1|SM |4089|420 AD4|MEF 8|4772|51 2C|NFAT 56|5600|5 C1|PDGF 629|6095| RA|MAPK 6935|713 11|PROX1 9|7140|10 |RORA|ZE GO GO:00426 266|1032 B1|TNNT 1 -3.3504 M1 1 0 Biological 19 muscle cell differentiation -3.3504 1.996812 3.832867 24156 388 873 28 3.207331 0.596329 -1.62347 0 13 0 0 -9.83559 6.28866 92 4|10529|2 2|TNNT3| Processes 7063|297 RAMP2|K 66|57486| LHL41|NE 57538|58 BL|ANKR 494|6409 D1|TMOD 1|91653|9 3|NLN|AL 3649|117 PK3|JAM2 166|1248 |POPDC2| 57 BOC|MY OCD|WFI KKN1|WFI GO 10733|25 PLK4|POC GO:00466 1 -3.34087 M1 1 0 Biological 19 positive regulation of centrosome cycle -3.34087 10.06186 5.820912 24156 11 873 4 0.45819 0.22857 886|5583 1A|CENPJ -1.61815 0 19 0 0 -7.81934 13.83505 07 Processes 5|85459 |CEP295 GO ITGB3|PE 3690|517 GO:00310 Cellular CAM1|LH 1 -2.55801 M1 1 0 20 platelet alpha granule membrane -2.55801 6.510612 4.401046 24156 17 873 4 0.45819 0.22857 5|10184|9 -1.03919 0 81 0 0 -3.97669 6.510612 92 Compone FPL2|SYTL 4121 nts 4 CCN2|TN GO 1490|713 GO:00702 FRSF1A|T 1 -3.34087 M1 1 0 Biological 19 extracellular matrix constituent secretion -3.34087 10.06186 5.820912 24156 11 873 4 0.45819 0.22857 2|7133|28 -1.61815 0 113 1 1 -3.34087 13.83505 78 NFRSF1B| Processes 984 RGCC ACTN2|C 88|983|47 DK1|NEK 51|5116|5 2|PCNT|P 420|5992| ODXL|RF 8655|942 X4|DYNLL 3|9662|97 1|NTN1|C 12|9814|1 EP135|US 0324|107 P6NL|SFI1 33|22871| |KLHL41|P 23216|23 LK4|NLG 433|2588 N1|TBC1 6|26084|2 D1|RHOQ 9780|510 |POC1A|A GO 98|51715| RHGEF26| GO:01200 plasma membrane bounded cell projection 1 -3.33369 M1 1 0 Biological 19 -3.33369 1.782142 3.724431 24156 590 873 38 4.352806 0.690579 54443|54 PARVB|IF -1.61252 0 12 0 0 -10.0997 6.06468 31 assembly Processes 820|5511 T52|RAB2 2|55125|5 3|ANLN|N 5785|558 DE1|WDR 35|79441| 60|CEP19 80184|84 2|FGD6|C 687|1171 ENPJ|HA 78|12144 US3|CEP2 1|152273| 90|PPP1R 161582|1 9B|SSX2IP 96527|33 |NEDD1|F 9829|347 GD5|DNA 240|1005 AF4|ANO 06658 6|CCDC3 9|KIF24|O ALDH1A3 220|238|1 |ALK|CDK 021|1385| 6|CREB1| 1600|204 DAB1|EP 8|2173|26 HB2|FABP 18|2902|3 7|GART|G 280|3624| RIN1|HES 5308|562 1|INHBA| 9|5992|63 PITX2|PR GO GO:00309 87|6491|7 OX1|RFX4 1 -3.33274 M1 1 0 Biological 19 forebrain development -3.33274 1.991678 3.818121 24156 389 873 28 3.207331 0.596329 -1.61252 0 78 0 0 -4.09519 2.557741 00 054|7852| |CXCL12|S Processes 8854|992 TIL|TH|CX 8|10460|1 CR4|ALD 0891|264 H1A2|KIF 68|54820| 14|TACC3 79648|84 |PPARGC 687|1394 1A|LHX6| 11|25926 NDE1|MC 6 PH1|PPP1 R9B|PTCH 135|655|1 ADORA2 021|1295| A|BMP7|C 1545|160 DK6|COL 0|2199|23 8A1|CYP1 35|2824|3 B1|DAB1| 280|3673| FBLN2|FN 3909|395 1|GPM6B| 8|3976|40 HES1|ITG 08|4155|5 A2|LAMA 270|5420| 3|LGALS3| 5795|638 LIF|LMO7| 7|6422|70 MBP|SER 57|7852|8 PINE2|PO GO 767|8772| DXL|PTPR GO:00301 1 -3.33108 M1 1 0 Biological 19 regulation of cell adhesion -3.33108 1.700397 3.683947 24156 716 873 44 5.040092 0.740427 9723|992 J|CXCL12| -1.61169 0 39 0 0 -5.93077 3.633448 55 Processes 8|10125|1 SFRP1|TH 0631|229 BS1|CXCR 98|25975| 4|RIPK2|F 28984|54 ADD|SEM 997|5582 A3E|KIF14 4|58494|7 |RASGRP1 9679|133 |POSTN|LI 584|1362 MCH1|EG 27|15188 FL6|RGCC 7|170692| |TESC|PA 284217|3 G1|JAM2| 75567|44 VTCN1|E 1478|729 GFLAM|C 230 OL26A1|C ADORA2 136|238|9 B|ALK|CD 83|1849|2 K1|DUSP7 247|3672| |FGF2|ITG GO 4916|560 A1|NTRK3 GO:00001 1 -3.31826 M1 1 0 Biological 19 activation of MAPK activity -3.31826 2.69514 4.086329 24156 154 873 15 1.718213 0.439813 0|7057|78 |MAPK11| -1.60135 0 18 0 0 -7.89792 2.69514 87 Processes 52|8767|1 THBS1|CX 0454|299 CR4|RIPK 69|79444| 2|TAB1|M 389400 DFIC|BIRC 7|GFRAL COL9A3|I 1299|362 NHBA|SM 4|4089|51 AD4|PDG 56|6422|7 FRA|SFRP 022|8743| GO 1|TFAP2C GO:00465 development of primary male sexual 10184|23 1 -3.31277 M1 1 0 Biological 19 -3.31277 2.807112 4.122374 24156 138 873 14 1.603666 0.425147 |TNFSF10| -1.59751 0 89 0 0 -3.75072 2.95506 46 characteristics 414|2359 Processes LHFPL2|Z 8|30812|8 FPM2|PA 1930|259 TZ1|SOX8 266|6426 |KIF18A|A 58 SPM|SCX BRCA2|G 675|2620| AS2|INHB 3624|507 A|PARN|A 3|6790|71 URKA|TN GO 30|7153|7 FAIP6|TO GO:00072 1 -3.31277 M1 1 0 Biological 19 female gamete generation -3.31277 2.807112 4.122374 24156 138 873 14 1.603666 0.425147 272|9319| P2A|TTK| -1.59751 0 114 1 1 -3.31277 5.355504 92 Processes 23397|84 TRIP13|N 930|8531 CAPH|MA 5|254394| STL|PAQR 259266 8|MCM9| ASPM BRCA1|BR 672|675|8 CA2|CAS 35|983|30 P2|CDK1| GO 90|5366|6 HIC1|PM GO:00303 DNA damage response, signal transduction 1 -3.30978 M1 1 0 Biological 19 -3.30978 3.103189 4.221948 24156 107 873 12 1.37457 0.394068 790|7029| AIP1|AUR -1.59534 0 30 0 0 -6.32789 4.035223 30 by p53 class mediator Processes 27063|28 KA|TFDP2 984|5151 |ANKRD1| 2|144455 RGCC|GT SE1|E2F7 CHRNA1| GABRA2| 1134|255 GO transmitter-gated ion channel activity GABRA3| GO:19043 5|2556|25 1 -2.54553 M1 1 0 Molecular 21 involved in regulation of postsynaptic -2.54553 3.654542 3.746133 24156 53 873 7 0.801833 0.301847 GABRA4| -1.03036 0 112 0 0 -3.34087 10.06186 15 57|2565|2 Functions membrane potential GABRG1| 890|2902 GRIA1|GR IN1 ADORA2 A|XIAP|BI 135|331|3 RC5|C4A| 32|720|12 CNN3|CO 66|1294|3 L7A1|LGA 958|5270| LS3|SERPI 6692|705 NE2|SPIN 7|7078|70 T1|THBS1 79|7139|7 |TIMP3|TI 980|9104| MP4|TNN 9232|981 T2|TFPI2| GO 4|10788|2 RGN|PTT GO:00513 1 -3.2998 M1 1 0 Biological 19 negative regulation of hydrolase activity -3.2998 1.883922 3.747211 24156 470 873 32 3.665521 0.635992 3504|511 G1|SFI1|I -1.587 0 116 1 1 -3.2998 2.23146 46 Processes 29|55031| QGAP2|RI 55125|57 MBP2|AN 082|5771 GPTL4|US 8|79444|8 P47|CEP1 0760|846 92|KNL1| 87|84930| PPP4R4|B 117166|1 IRC7|ITIH 24857|14 5|PPP1R9 0902|392 B|MASTL| 617 WFIKKN1| WFIKKN2| R3HDML| 2103|499 ESRRB|OR GO GO:00000 regulation of transcription involved in G1/S 8|6241|70 C1|RRM2| 1 -3.29248 M1 1 0 Biological 19 -3.29248 5.724849 4.929767 24156 29 873 6 0.687285 0.279617 -1.5805 0 109 0 0 -3.37978 5.929308 83 transition of mitotic cell cycle 29|8318|1 TFDP2|CD Processes 44455 C45|E2F7 CDK1|CE 983|1063| NPF|CREB 1385|204 1|EPHB1| 7|2247|40 FGF2|SM 89|4208|5 GO AD4|MEF GO:19018 600|7093| 1 -3.28848 M1 1 0 Biological 19 regulation of muscle tissue development -3.28848 2.677752 4.057608 24156 155 873 15 1.718213 0.439813 2C|MAPK -1.57885 0 117 1 1 -3.28848 6.510612 61 10324|10 Processes 11|TLL2|K 413|1089 LHL41|YA 1|23414|5 P1|PPAR 7486|936 GC1A|ZFP 49 M2|NLN| AGTR2|C 186|947|3 GO D34|HES1 GO:00722 280|3976| 1 -3.28677 M1 1 0 Biological 19 metanephric nephron development -3.28677 4.842268 4.709298 24156 40 873 7 0.801833 0.301847 |LIF|PDGF -1.57885 0 118 1 1 -3.28677 7.905744 10 5156|107 Processes RA|SIX2|S 36|30812 OX8 6491|679 STIL|AUR 0|7272|95 KA|TTK|KI GO GO:00726 protein localization to microtubule 85|55125| F20B|CEP 1 -3.28586 M1 1 0 Biological 19 -3.28586 4.256939 4.552583 24156 52 873 8 0.91638 0.322501 -1.57875 0 66 0 0 -4.4085 4.770707 98 cytoskeleton 79648|12 192|MCP Processes 1441|246 H1|NEDD 176 1|GAS2L2 AGTR2|B 186|655|9 MP7|CD3 GO 47|3280|4 4|HES1|M GO:00328 1 -3.27941 M1 1 0 Biological 19 glomerulus development -3.27941 3.831245 4.425862 24156 65 873 9 1.030928 0.341867 208|5156| EF2C|PDG -1.5731 0 119 1 1 -3.27941 18.44674 35 Processes 5175|542 FRA|PECA 0|23213 M1|PODX L|SULF1 BRCA2|C 675|835|1 ASP2|COL 299|2620| 9A3|GAS2 3624|408 |INHBA|S 9|5156|64 MAD4|PD 22|7022|8 GFRA|SFR GO 743|1018 GO:00451 development of primary sexual P1|TFAP2 1 -3.27364 M1 1 0 Biological 19 -3.27364 2.347018 3.921922 24156 224 873 19 2.176403 0.493838 4|10468|2 -1.56858 0 89 0 0 -3.75072 2.95506 37 characteristics C|TNFSF1 Processes 3414|235 0|LHFPL2| 98|30812| FST|ZFPM 81930|15 2|PATZ1| 7506|259 SOX8|KIF 266|6426 18A|RDH 58 10|ASPM| CASP2|C 835|983|4 DK1|MRE 361|4998| 11|ORC1| 6790|702 GO AURKA|TF GO:00447 9|7153|28 1 -3.27286 M1 1 0 Biological 19 mitotic DNA integrity checkpoint -3.27286 3.074456 4.18377 24156 108 873 12 1.37457 0.394068 DP2|TOP -1.56858 0 30 0 0 -6.32789 4.035223 74 984|5151 Processes 2A|RGCC| 2|63967|1 GTSE1|CL 44455|14 SPN|E2F7| 6956 EME1 GABRA2| 2555|255 GABRA3| KEGG 6|2557|25 GABRA4| 1 -2.53146 hsa05033 M1 1 0 24 Nicotine addiction -2.53146 4.150515 3.861448 24156 40 873 6 0.687285 0.279617 -1.02094 0 112 0 0 -3.34087 10.06186 Pathway 65|2890|2 GABRG1| 902 GRIA1|GR IN1 ALDH1A3 220|238|1 |ALK|CDK 021|1600| 6|DAB1|E 2048|261 PHB2|GA 8|2902|32 RT|GRIN1 80|3624|5 |HES1|IN GO 629|5992| HBA|PRO GO:00215 1 -3.27248 M1 1 0 Biological 19 telencephalon development -3.27248 2.234893 3.876543 24156 260 873 21 2.405498 0.518571 6387|705 X1|RFX4| -1.56858 0 78 0 0 -4.09519 2.557741 37 Processes 4|7852|99 CXCL12|T 28|10460| H|CXCR4| 26468|54 KIF14|TA 820|7964 CC3|LHX6 8|84687|2 |NDE1|M 59266 CPH1|PPP 1R9B|ASP ACTC1|A DORA2A| AHR|BMP 70|135|19 7|CDK1|C 6|655|983 DO1|CHR |1036|113 NA1|SLC3 4|1317|13 1A1|CREB 85|1393|1 1|CRHBP| 545|1789| CYP1B1|D 1816|189 NMT3B|D 4|2882|29 RD5|ECT2 02|3039|4 |GPX7|GR GO 155|4233| GO:00096 IN1|HBA1 1 -3.26614 M1 1 0 Biological 19 response to toxic substance -3.26614 1.816986 3.693192 24156 533 873 35 4.009164 0.663949 4916|517 -1.56305 0 120 1 1 -3.26614 6.385408 36 |MBP|ME Processes 9|5742|69 T|NTRK3| 15|7054|7 PENK|PT 296|9104| GS1|TBXA 10276|10 2R|TH|TX 516|1058 NRD1|RG 7|10891|5 N|NET1|F 4464|571 BLN5|TX 65|84687| NRD2|PP 137902|1 ARGC1A| 40809 XRN1|GJC 2|PPP1R9 B|PXDNL| ADORA2 136|238|9 B|ALK|CD 83|1849|1 K1|DUSP7 894|2247| |ECT2|FGF 3672|369 2|ITGA1|I 0|4214|49 TGB3|MA 16|5600|7 P3K1|NTR 057|7852| K3|MAPK GO GO:00321 8767|992 11|THBS1 1 -3.26441 M1 1 0 Biological 19 activation of protein kinase activity -3.26441 2.064933 3.800633 24156 335 873 25 2.863688 0.564477 -1.56292 0 18 0 0 -7.89792 2.69514 47 8|9966|10 |CXCR4|RI Processes 454|2297 PK2|KIF14 4|28984|2 |TNFSF15| 9969|560 TAB1|TPX 34|63967| 2|RGCC| 79444|79 MDFIC|P 866|3894 DGFC|CLS 00 PN|BIRC7| BORA|GF ACTC1|IT 70|3672|3 GA1|ITGA 673|3690| 2|ITGB3|I KEGG 1 -2.51714 hsa05410 M1 1 0 24 Hypertrophic cardiomyopathy (HCM) -2.51714 3.000373 3.534891 24156 83 873 9 1.030928 0.341867 3691|556 TGB4|PRK -1.00867 0 186 1 1 -2.51714 11.06804 Pathway 3|6445|71 AA2|SGC 39|10369 G|TNNT2| CACNG2 ADORA2 A|ASPA|C 135|443|9 DK1|CDK 83|1021|1 6|DAB1|G 600|2840| PR17|HES 3280|397 1|LIF|NTR GO 6|4916|52 GO:00100 K3|SERPI 1 -3.2499 M1 1 0 Biological 19 glial cell differentiation -3.2499 2.336586 3.90031 24156 225 873 19 2.176403 0.493838 70|5354|6 -1.55079 0 56 0 0 -4.84716 6.385408 01 NE2|PLP1 Processes 692|7133| |SPINT1|T 7223|785 NFRSF1B| 2|8726|30 TRPC4|CX 812|8393 CR4|EED| 3|85414 SOX8|HD AC10|SLC ADORA2 A|CRHBP| 135|1393| DNMT3B| 1789|181 DRD5|GRI GO 6|2902|51 GO:00432 N1|PENK| 1 -3.23644 M1 1 0 Biological 19 response to alkaloid -3.23644 3.04625 4.146032 24156 109 873 12 1.37457 0.394068 79|7054|7 -1.53812 0 123 1 1 -3.23644 5.764605 79 TH|TIAM1 Processes 074|7852| |CXCR4|F 8772|108 ADD|PPA 91|84687 RGC1A|P PP1R9B 2491|593 CENPI|RB 1|23421|5 BP7|ITGB GO GO:00063 DNA replication-independent nucleosome 5355|558 3BP|HJUR 1 -3.22859 M1 1 0 Biological 19 -3.22859 4.176619 4.482897 24156 53 873 8 0.91638 0.322501 -1.53184 0 31 0 0 -6.31644 12.57732 36 assembly 39|57082| P|CENPN| Processes 91687|40 KNL1|CE 1541 NPL|CEN MEF2C|C 4208|954 XCL14|KL 7|10324|3 GO HL41|SOX GO:00456 0812|916 1 -3.22859 M1 1 0 Biological 19 regulation of myoblast differentiation -3.22859 4.176619 4.482897 24156 53 873 8 0.91638 0.322501 8|BOC|M -1.53184 0 124 1 1 -3.22859 6.58812 61 53|93649| Processes YOCD|PRI 144165|2 CKLE1|RA 02151 NBP3L 1062|383 CENPE|KI 2|9493|95 F11|KIF23 85|11004| |KIF20B|KI R-HSA- Reactome COPI-dependent Golgi-to-ER retrograde 1 -2.50959 M1 1 0 6 -2.50959 2.79496 3.465316 24156 99 873 10 1.145475 0.360151 24137|26 F2C|KIF4A -1.00367 0 46 0 0 -5.44351 7.281606 6811434 Gene Sets traffic 153|7986 |KIF26A|T 1|81027|8 UBAL3|TU 1930 BB1|KIF18 BMP7|CD H11|CRA 655|1009| BP2|CREB 1382|138 1|DAB1|E 5|1600|20 PHB1|EP 47|2048|2 HB2|FN1| 335|2803| GOLGA4| 2902|328 GRIN1|HE 0|3706|40 S1|ITPKA| 89|4208|4 SMAD4| 902|4916| MEF2C|N 4974|638 RTN|NTR 7|6498|70 K3|OMG| GO 74|7852|9 CXCL12|S GO:00486 cell morphogenesis involved in neuron 1 -3.2232 M1 1 0 Biological 19 -3.2232 1.758301 3.635918 24156 598 873 38 4.352806 0.690579 423|9723| KIL|TIAM -1.52724 0 29 0 0 -6.42481 3.074456 67 differentiation Processes 11141|22 1|CXCR4| 871|2323 NTN1|SE 7|23768|2 MA3E|IL1 6037|544 RAPL1|NL 37|55816| GN1|ARC| 84570|84 FLRT2|SIP 612|8544 A1L1|SEM 2|91624|9 A5B|DOK 1653|133 5|COL25A 584|2842 1|PARD6B 17|28465 |KNDC1| 6 NEXN|BO C|EGFLA M|LAMA1 ACTC1|FZ 70|2535|4 D2|SMAD 089|5081| 4|PAX7|P GO GO:00604 5629|713 ROX1|TN 1 -3.21967 M1 1 0 Biological 19 muscle tissue morphogenesis -3.21967 3.458763 4.265409 24156 80 873 10 1.145475 0.360151 -1.52578 0 75 0 0 -4.23321 3.816566 15 5|7139|23 NI1|TNNT Processes 414|2706 2|ZFPM2| 3|54567 ANKRD1| DLL4 672|6491| BRCA1|ST GO 9662|107 IL|CEP135 GO:00985 1 -3.21906 M1 1 0 Biological 19 centriole assembly -3.21906 4.724164 4.621344 24156 41 873 7 0.801833 0.301847 33|55835| |PLK4|CE -1.52578 0 19 0 0 -7.81934 13.83505 34 Processes 56890|85 NPJ|MDM 459 1|CEP295 XIAP|BIRC 331|332|7 5|C4A|CO 20|1294|5 L7A1|SER 270|6692| PINE2|SPI 7078|707 NT1|TIMP GO GO:00304 9|7980|92 3|TIMP4|T 1 -2.49434 M1 1 0 Molecular 21 peptidase inhibitor activity -2.49434 2.23146 3.26463 24156 186 873 15 1.718213 0.439813 -0.99044 0 116 0 0 -3.2998 2.23146 14 32|79444| FPI2|PTT Functions 80760|11 G1|BIRC7| 7166|124 ITIH5|WFI 857|1409 KKN1|WFI 02 KKN2|R3 HDML CENPE|KI 1062|383 F11|PLA2 2|5321|86 G4A|DYN 55|9493|9 LL1|KIF23| R-HSA- Reactome 585|1100 1 -2.48893 M1 1 0 6 Golgi-to-ER retrograde transport -2.48893 2.496551 3.351157 24156 133 873 12 1.37457 0.394068 KIF20B|KI -0.98604 0 46 0 0 -5.44351 7.281606 8856688 Gene Sets 4|24137|2 F2C|KIF4A 6153|798 |KIF26A|T 61|81027| UBAL3|TU 81930 BB1|KIF18 1385|190 CREB1|ED GO 7|2324|39 N2|FLT4|L GO:00482 1 -3.21906 M1 1 0 Biological 19 lung alveolus development -3.21906 4.724164 4.621344 24156 41 873 7 0.801833 0.301847 76|64759| IF|TNS3|P -1.52578 0 34 0 0 -6.2407 4.724164 86 Processes 91461|93 KDCC|MY 649 OCD 2619|328 GAS1|HES 0|5167|52 1|ENPP1| 70|5992|6 SERPINE2 095|6422| |RFX4|RO GO GO:00072 6491|510 RA|SFRP1 1 -3.21859 M1 1 0 Biological 19 smoothened signaling pathway -3.21859 2.747386 4.029474 24156 141 873 14 1.603666 0.425147 -1.52578 0 125 1 1 -3.21859 2.747386 24 98|55835| |STIL|IFT5 Processes 57540|91 2|CENPJ| 653|1394 DISP3|BO 11|22266 C|PTCHD 3 1|SCUBE3 BRCA2|C 675|1021| DK6|CDK 1030|224 N2B|FGF2 7|2277|23 |VEGFD|F 24|3280|3 LT4|HES1| 357|3690| HTR2B|IT 4208|522 GB3|MEF 8|5587|56 2C|PGF|P 29|6387|6 RKD1|PR GO GO:00506 422|7057| OX1|CXC 1 -3.21146 M1 1 0 Biological 19 regulation of epithelial cell proliferation -3.21146 1.956472 3.716103 24156 396 873 28 3.207331 0.596329 -1.51942 0 68 0 0 -4.38679 2.76701 78 8854|910 L12|SFRP Processes 4|10413|2 1|THBS1| 3213|289 ALDH1A2 84|29128| |RGN|YAP 51098|54 1|SULF1|R 567|5760 GCC|UHR 8|64102|1 F1|IFT52| 16039|44 DLL4|JCA 1478 D|TNMD| OSR2|NR BMP7|CD 655|1021| K6|FBN2| 2201|282 GPM6B|S 4|4090|42 MAD5|M 08|5167|5 EF2C|ENP 587|6422| GO P1|PRKD1 GO:00302 9249|107 1 -3.20979 M1 1 0 Biological 19 regulation of ossification -3.20979 2.383071 3.88851 24156 209 873 18 2.061856 0.480948 |SFRP1|D -1.51853 0 65 0 0 -4.41834 4.966429 78 36|56172| Processes HRS3|SIX 91461|11 2|ANKH|P 6039|117 KDCC|OS 581|1965 R2|TWIST 27|20215 2|ANO6|R 1|359845 ANBP3L|R GO 3691|386 ITGB4|KR GO:00315 1 -3.17736 M1 1 0 Biological 19 hemidesmosome assembly -3.17736 9.223368 5.517304 24156 12 873 4 0.45819 0.22857 1|3909|39 T14|LAM -1.49074 0 77 0 0 -4.11211 18.44674 81 Processes 14 A3|LAMB MET|PEC GO 4233|517 GO:00018 AM1|ARH 1 -3.17736 M1 1 0 Biological 19 endothelial cell morphogenesis -3.17736 9.223368 5.517304 24156 12 873 4 0.45819 0.22857 5|26084|6 -1.49074 0 127 1 1 -3.17736 9.223368 86 GEF26|TN Processes 4102 MD 2491|593 CENPI|RB 1|23421|5 BP7|ITGB GO GO:00347 DNA replication-independent nucleosome 5355|558 3BP|HJUR 1 -3.17273 M1 1 0 Biological 19 -3.17273 4.099275 4.414907 24156 54 873 8 0.91638 0.322501 -1.48842 0 31 0 0 -6.31644 12.57732 24 organization 39|57082| P|CENPN| Processes 91687|40 KNL1|CE 1541 NPL|CEN CORUM:2 FA core complex (Fanconi anemia core 2187|218 FANCB|F 1 -2.47423 M1 1 0 CORUM 33 -2.47423 9.223368 4.777828 24156 9 873 3 0.343643 0.198061 -0.97635 0 44 0 0 -5.52611 9.223368 45 complex) 8|80010 ANCF|RM 2187|218 FANCB|F 8|9937|55 ANCF|DC GO GO:00362 215|9144 LRE1A|FA 1 -3.17273 M1 1 0 Biological 19 interstrand cross-link repair -3.17273 4.099275 4.414907 24156 54 873 8 0.91638 0.322501 -1.48842 0 44 0 0 -5.52611 9.223368 97 2|146956| NCI|FAAP Processes 254394|3 24|EME1| 53497 MCM9|P ALK|BMP 7|CRABP2 238|655|1 |DAB1|DN 382|1600| MT3B|EC 1789|189 T2|FN1|G 4|2335|28 OLGA4|IT 03|3706|4 PKA|MEF 208|4916| 2C|NTRK3 5121|558 |PCP4|PR GO 7|5629|63 GO:00456 KD1|PRO 1 -3.14971 M1 1 0 Biological 19 positive regulation of neuron differentiation -3.14971 1.966034 3.67541 24156 380 873 27 3.092784 0.58593 87|6498|6 -1.46616 0 29 0 0 -6.42481 3.074456 66 X1|CXCL1 Processes 935|7074| 2|SKIL|ZE 7852|942 B1|TIAM1 3|11141|2 |CXCR4|N 2871|270 TN1|IL1R 63|15183 APL1|NLG 5|285016| N1|ANKR 339479|3 D1|CPNE 75567 9|ALKAL2| BRINP3|V R-HSA- Reactome E2F-enabled inhibition of pre-replication 983|4998| CDK1|OR 1 -2.47423 M1 1 0 6 -2.47423 9.223368 4.777828 24156 9 873 3 0.343643 0.198061 -0.97635 0 138 0 0 -3.01725 11.06804 113507 Gene Sets complex formation 4999 C1|ORC2 COL9A3|I 1299|362 NHBA|SM 4|4089|40 AD4|SMA 90|5156|6 D5|PDGF 422|7022| RA|SFRP1 GO GO:00466 8743|101 |TFAP2C| 1 -3.14393 M1 1 0 Biological 19 male sex differentiation -3.14393 2.594072 3.917326 24156 160 873 15 1.718213 0.439813 -1.46115 0 89 0 0 -3.75072 2.95506 61 84|23414| TNFSF10| Processes 23598|30 LHFPL2|Z 812|8193 FPM2|PA 0|259266| TZ1|SOX8 642658 |KIF18A|A SPM|SCX EPHB1|EP 2047|204 HB2|NTR 8|4916|70 GO K3|THBS2 GO:00519 58|11141| 1 -3.13321 M1 1 0 Biological 19 positive regulation of synapse assembly -3.13321 3.66222 4.256858 24156 68 873 9 1.030928 0.341867 |IL1RAPL1 -1.45119 0 63 0 0 -4.50244 10.37629 65 22871|23 Processes |NLGN1|F 768|5467 LRT2|LRR 4|347730 N3|LRRT ALOX5|C MKLR1|E 240|1240| DN2|EDN 1907|190 3|EPHB1| 8|2047|22 FGF2|VEG 47|2277|3 FD|HRH1| 269|3672| ITGA1|LG 3958|423 GO ALS3|MET GO:00603 3|5156|52 1 -3.13114 M1 1 0 Biological 19 cell chemotaxis -3.13114 2.093462 3.715088 24156 304 873 23 2.634593 0.542066 |PDGFRA| -1.44988 0 42 0 0 -5.75682 3.654542 26 28|5587|6 Processes PGF|PRK 387|7057| D1|CXCL1 7074|785 2|THBS1| 2|9547|51 TIAM1|CX 554|7914 CR4|CXCL 8|196527| 14|ACKR4 729230 |MMP28| ANO6|CC 1287|128 COL4A5| R-HSA- Reactome 1 -2.46134 M1 1 0 6 Crosslinking of collagen fibrils -2.46134 6.148912 4.231479 24156 18 873 4 0.45819 0.22857 8|4017|70 COL4A6|L -0.96694 0 5 0 0 -15.2617 12.29782 2243919 Gene Sets 93 OXL2|TLL GO 4361|915 MRE11|E GO:00084 1 -2.46134 M1 1 0 Molecular 21 5'-3' exonuclease activity -2.46134 6.148912 4.231479 24156 18 873 4 0.45819 0.22857 6|9937|54 XO1|DCL -0.96694 0 188 1 1 -2.46134 6.917526 09 Functions 464 RE1A|XR AURKA|T 6790|715 GO OP2A|TT GO:00071 3|7272|93 1 -3.12886 M1 1 0 Biological 19 female meiotic nuclear division -3.12886 5.355504 4.69869 24156 31 873 6 0.687285 0.279617 K|TRIP13| -1.44988 0 114 0 0 -3.31277 5.355504 43 19|23397| Processes NCAPH| 84930 MASTL BMP7|ED 655|1908| N3|FN1|H GO 2335|335 GO:00017 TR2B|NRT 1 -3.11824 M1 1 0 Biological 19 neural crest cell migration -3.11824 4.024742 4.348539 24156 55 873 8 0.91638 0.322501 7|4902|53 -1.44001 0 28 0 0 -6.45792 4.716495 55 N|PITX2|S Processes 08|9723|3 EMA3E|S 0812 OX8 2047|420 EPHB1|M GO GO:20010 regulation of skeletal muscle cell 8|10324|5 EF2C|KLH 1 -3.11621 M1 1 0 Biological 19 -3.11621 6.58812 4.960699 24156 21 873 5 0.572738 0.255402 -1.43915 0 124 0 0 -3.22859 6.58812 14 differentiation 7486|936 L41|NLN| Processes 49 MYOCD 672|835|9 BRCA1|C 83|4361|4 ASP2|CD 998|6790| K1|MRE1 7029|715 1|ORC1|A GO GO:00315 3|8318|28 URKA|TF 1 -3.11586 M1 1 0 Biological 19 DNA integrity checkpoint -3.11586 2.57796 3.889911 24156 161 873 15 1.718213 0.439813 -1.43915 0 30 0 0 -6.32789 4.035223 70 984|5151 DP2|TOP Processes 2|51514|6 2A|CDC4 3967|144 5|RGCC|G 455|1469 TSE1|DTL| 56 CLSPN|E2 186|355|1 AGTR2|FA 490|1894| S|CCN2|E 2247|233 CT2|FGF2| 5|2902|33 FN1|GRIN 57|3672|3 1|HTR2B|I 673|4155| TGA1|ITG 4208|491 A2|MBP| 6|5156|53 MEF2C|N 66|5587|6 TRK3|PD 422|7074| GFRA|PM 7139|865 AIP1|PRK 5|8743|87 D1|SFRP1 67|8772|8 |TIAM1|T GO 853|9104| NNT2|DY GO:00513 1 -3.11246 M1 1 0 Biological 19 positive regulation of hydrolase activity -3.11246 1.638127 3.50103 24156 777 873 46 5.269187 0.756154 9712|981 NLL1|TNF -1.43649 0 130 1 1 -3.11246 1.704318 45 Processes 5|9824|99 SF10|RIPK 38|9966|1 2|FADD|A 0125|102 SAP2|RG 76|22821| N|USP6N 23151|23 L|GIT2|AR 216|2339 HGAP11A 7|25780|2 |ARHGAP 6037|291 25|TNFSF 28|55112| 15|RASGR 55635|55 P1|NET1| 789|5756 RASA3|G 8|85397|2 RAMD4|T 02151|25 BC1D1|N 5520 CAPH|RA BARD1|B 580|672|2 Canonical RCA1|FA 1 -2.45386 M258 M1 1 0 11 PID BARD1 PATHWAY -2.45386 4.770707 3.934245 24156 29 873 5 0.572738 0.255402 188|4361| -0.96291 0 70 0 0 -4.32747 27.6701 Pathways NCF|MRE 7520 11|XRCC5 CRABP2| 1382|160 DAB1|EP 0|2048|23 HB2|FN1| 35|2620|2 GAS2|GO 803|2902| LGA4|GRI 3706|491 N1|ITPKA| 6|4974|63 NTRK3|O 87|6498|7 MG|CXCL 074|7456| 12|SKIL|TI 7852|942 AM1|WIP 3|9723|10 F1|CXCR4 GO GO:00226 631|1114 |NTN1|SE 1 -3.10644 M1 1 0 Biological 19 regulation of cell morphogenesis -3.10644 1.815335 3.578228 24156 503 873 33 3.780069 0.645469 -1.43123 0 29 0 0 -6.42481 3.074456 04 1|22871|2 MA3E|PO Processes 3237|234 STN|IL1R 33|26037| APL1|NLG 29780|55 N1|ARC|R 023|5517 HOQ|SIP 1|55785|5 A1L1|PAR 7381|576 VB|PHIP|T 19|85442| BCCD1|F 151835|1 GD6|RHO 52273|15 J|SHROO 7285 M3|KNDC 1|CPNE9| 655|2201| BMP7|FB 2824|420 N2|GPM6 8|5167|57 B|MEF2C| GO 44|56172| ENPP1|PT GO:00302 1 -3.0955 M1 1 0 Biological 19 bone mineralization -3.0955 2.938418 3.999296 24156 113 873 12 1.37457 0.394068 91461|11 HLH|ANK -1.42178 0 65 0 0 -4.41834 4.966429 82 Processes 6039|196 H|PKDCC| 527|3404 OSR2|AN 19|35984 O6|RSPO 5 2|RFLNB ITGA2|LG 3673|395 GO ALS3|THB GO:00432 8|7057|64 1 -2.45386 M1 1 0 Molecular 21 laminin binding -2.45386 4.770707 3.934245 24156 29 873 5 0.572738 0.255402 S1|TINAG -0.96291 0 191 1 1 -2.45386 4.770707 36 129|1315 Functions L1|LRRC1 78 5 FBLN2|IT 2199|367 GA2|ITGB GO 3|3690|39 GO:00508 3|LGALS3| 1 -2.45308 M1 1 0 Molecular 21 extracellular matrix binding -2.45308 3.521649 3.625265 24156 55 873 7 0.801833 0.301847 58|7057|6 -0.96262 0 191 0 0 -2.45386 4.770707 40 THBS1|TI Functions 4129|131 NAGL1|LR 578 RC15 COL5A1| 1289|130 COL15A1| 6|1490|36 CCN2|ITG 73|4312|4 A2|MMP1 GO GO:00329 316|9508| |MMP7|A 1 -3.0955 M1 1 0 Biological 19 collagen metabolic process -3.0955 2.938418 3.999296 24156 113 873 12 1.37457 0.394068 -1.42178 0 88 0 0 -3.79065 3.532354 63 28984|55 DAMTS3| Processes 214|6406 RGCC|P3 6|79148|6 H2|MMP2 42658 7|MMP28 |SCX BRCA2|C 675|983|7 DK1|TTK| 272|7520| XRCC5|N GO 10403|27 GO:00345 DC80|MT 1 -3.09232 M1 1 0 Biological 19 protein localization to chromosome -3.09232 3.333747 4.124003 24156 83 873 10 1.145475 0.360151 085|5550 -1.42029 0 57 0 0 -4.71552 16.60206 02 BP|MACR Processes 6|57082|7 OH2A2|K 9003|254 NL1|MIS1 394 2|MCM9 2335|367 FN1|ITGA 2|3673|40 1|ITGA2|L GO GO:00055 60|4089|7 UM|SMA 1 -2.43445 M1 1 0 Molecular 21 collagen binding -2.43445 3.162297 3.508111 24156 70 873 8 0.91638 0.322501 -0.95179 0 191 0 0 -2.45386 4.770707 18 057|1315 D4|THBS1 Functions 78|14737 |LRRC15| 2 CCBE1 ASPA|HES 443|3280| 1|LIF|SER GO GO:00456 positive regulation of glial cell 3976|527 PINE2|SPI 1 -3.08989 M1 1 0 Biological 19 -3.08989 4.504435 4.453668 24156 43 873 7 0.801833 0.301847 -1.42029 0 56 0 0 -4.84716 6.385408 87 differentiation 0|6692|71 NT1|TNF Processes 33|7852 RSF1B|CX CR4 BARD1|B 580|672|6 RCA1|BR R-HSA- Reactome Homologous DNA Pairing and Strand 75|4361|9 1 -2.42228 M1 1 0 6 -2.42228 3.952872 3.708735 24156 42 873 6 0.687285 0.279617 CA2|MRE -0.95179 0 70 0 0 -4.32747 27.6701 5693579 Gene Sets Exchange 156|8001 11|EXO1| 0 RMI1 GABRA2| GO 2555|255 GABRA3| GO:00325 Cellular 6|2557|25 GABRA4| 1 -2.42228 M1 1 0 20 dendrite membrane -2.42228 3.952872 3.708735 24156 42 873 6 0.687285 0.279617 -0.95179 0 112 0 0 -3.34087 10.06186 90 Compone 65|2890|8 GABRG1| nts 4687 GRIA1|PP P1R9B CORUM:6 2199|220 FBLN2|FB 1 -2.41795 M1 1 0 CORUM 33 ELN-FBLN2-FBN1 complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 24 0 0 -7.35548 20.75258 913 0 N1 CORUM:6 2200|105 FBN1|FBL 1 -2.41795 M1 1 0 CORUM 33 ELN-FBLN5-FBN1 complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 24 0 0 -7.35548 20.75258 914 16 N5 CORUM:3 10051|10 SMC4|SM 1 -2.41795 M1 1 0 CORUM 33 DNA ligase IV-condensin complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 36 0 0 -6.06241 22.13608 53 592 C2 GO GO:00007 Cellular 10051|10 SMC4|SM 1 -2.41795 M1 1 0 20 condensin core heterodimer -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 36 0 0 -6.06241 22.13608 97 Compone 592 C2 nts CORUM:3 Ubiquitin E3 ligase (SMURF2, SMAD3) - 6498|647 SKIL|SMU 1 -2.41795 M1 1 0 CORUM 33 -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 55 0 0 -4.87217 18.44674 972 SnoN complex, TGF(beta)-dependent 50 RF2 GO GO:00301 7139|714 TNNT2|T 1 -2.41795 M1 1 0 Molecular 21 troponin C binding -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 61 0 0 -4.53228 18.44674 72 0 NNT3 Functions CORUM:2 BARD1|B 1 -2.41795 M1 1 0 CORUM 33 BRCA1-BARD1-POLR2A complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 580|672 -0.95179 0 70 0 0 -4.32747 27.6701 213 RCA1 CORUM:2 BRCA1|L 1 -2.41795 M1 1 0 CORUM 33 BRCA1-LMO4-CTIP complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 672|8543 -0.95179 0 70 0 0 -4.32747 27.6701 215 MO4 CORUM:2 BARD1|B 1 -2.41795 M1 1 0 CORUM 33 BARD1-BRCA1-CSTF64 complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 580|672 -0.95179 0 70 0 0 -4.32747 27.6701 783 RCA1 CORUM:2 BARD1|B 1 -2.41795 M1 1 0 CORUM 33 BRCA1 B complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 580|672 -0.95179 0 70 0 0 -4.32747 27.6701 788 RCA1 CORUM:2 E3 ubiquitin ligase (BRCA1, BARD1) - BARD1|B 1 -2.41795 M1 1 0 CORUM 33 -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 580|672 -0.95179 0 70 0 0 -4.32747 27.6701 822 UbcH5c complex RCA1 CORUM:2 BARD1|B 1 -2.41795 M1 1 0 CORUM 33 BRCA1-BARD1-UbcH7c complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 580|672 -0.95179 0 70 0 0 -4.32747 27.6701 823 RCA1 CORUM:6 BARD1|B 1 -2.41795 M1 1 0 CORUM 33 BARD1u2013BRCA1u2013RAD51 complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 580|672 -0.95179 0 70 0 0 -4.32747 27.6701 946 RCA1 GO GO:00056 Cellular 3909|391 LAMA3|L 1 -2.41795 M1 1 0 20 laminin-5 complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 77 0 0 -4.11211 18.44674 10 Compone 4 AMB3 nts CORUM:7 1894|949 ECT2|KIF2 1 -2.41795 M1 1 0 CORUM 33 ECT2-KIF23-RACGAP1 complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 102 0 0 -3.49473 18.44674 439 3 3 CDH5|CD 1003|100 H7|CDH9| 5|1007|10 CDH10|C 08|1009|1 DH11|EC GO 894|5010| GO:00070 T2|CLDN1 1 -3.08964 M1 1 0 Biological 19 cell-cell junction assembly -3.08964 2.78846 3.943805 24156 129 873 13 1.489118 0.40992 5175|102 -1.42029 0 132 1 1 -3.08964 3.175258 43 1|PECAM Processes 66|64072| 1|RAMP2| 84612|22 CDH23|P 2256|100 ARD6B|C 506658 DHR3|OC GO GO:00971 Cellular 1894|949 ECT2|KIF2 1 -2.41795 M1 1 0 20 centralspindlin complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 102 0 0 -3.49473 18.44674 49 Compone 3 3 nts CORUM:5 CCNF|CD 1 -2.41795 M1 1 0 CORUM 33 CDK1-CCNB1-CCNF complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 899|983 -0.95179 0 110 0 0 -3.35124 18.44674 550 K1 CORUM:2 3690|705 ITGB3|TH 1 -2.41795 M1 1 0 CORUM 33 ITGAV-ITGB3-THBS1 complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 111 0 0 -3.35124 18.44674 846 7 BS1 ADORA2 A|AGTR2| 135|186|3 FAS|CASP 55|835|36 2|INHBA| 24|5366|6 PMAIP1|S GO 422|6498| GO:20012 positive regulation of apoptotic signaling FRP1|SKIL 1 -3.08903 M1 1 0 Biological 19 -3.08903 2.473305 3.831008 24156 179 873 16 1.832761 0.453972 7029|705 -1.42029 0 52 0 0 -5.08367 9.88218 35 pathway |TFDP2|T Processes 7|7078|87 HBS1|TIM 43|8772|5 P3|TNFSF 0486|538 10|FADD| 32|90427 G0S2|IL20 RA|BMF CORUM:2 BIRC5|AU 1 -2.41795 M1 1 0 CORUM 33 RasGAP-AURKA-survivin complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 332|6790 -0.95179 0 128 0 0 -3.12886 18.44674 581 RKA 655|2103| BMP7|ES 2247|328 RRB|FGF2 0|3976|40 |HES1|LIF| 17|4089|5 LOXL2|S GO GO:00198 629|6422| MAD4|PR 1 -3.08807 M1 1 0 Biological 19 stem cell population maintenance -3.08807 2.562047 3.862703 24156 162 873 15 1.718213 0.439813 -1.42029 0 10 0 0 -10.1376 3.952872 27 10413|10 OX1|SFRP Processes 736|2702 1|YAP1|SI 2|55183|7 X2|FOXD 9648|259 3|RIF1|M 266 CPH1|AS ACTC1|A CTN2|AG 70|88|186 TR2|BMP |655|983| 7|CDK1|H 3280|408 ES1|SMA GO 9|4208|51 GO:00350 D4|MEF2 1 -3.08807 M1 1 0 Biological 19 cardiocyte differentiation -3.08807 2.562047 3.862703 24156 162 873 15 1.718213 0.439813 56|5308|5 -1.42029 0 13 0 0 -9.83559 6.28866 51 C|PDGFR Processes 629|1052 A|PITX2|P 9|57538|9 ROX1|NE 3649|144 BL|ALPK3| 165 MYOCD|P RICKLE1 CORUM:5 FAS|FAD 1 -2.41795 M1 1 0 CORUM 33 DISC complex (FAS, FADD, CASP8) -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 355|8772 -0.95179 0 141 0 0 -2.97821 18.44674 473 D CORUM:5 FAS|FAD 1 -2.41795 M1 1 0 CORUM 33 DISC complex (FAS, FADD, CASP8) -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 355|8772 -0.95179 0 141 0 0 -2.97821 18.44674 800 D CORUM:5 FAS|FAD 1 -2.41795 M1 1 0 CORUM 33 DISC complex (CD95, FADD, CASP8) -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 355|8772 -0.95179 0 141 0 0 -2.97821 18.44674 808 D CORUM:5 FAS|FAD 1 -2.41795 M1 1 0 CORUM 33 DISC complex (FAS, FADD, CASP8) -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 355|8772 -0.95179 0 141 0 0 -2.97821 18.44674 860 D CORUM:5 FAS|FAD 1 -2.41795 M1 1 0 CORUM 33 FAS-FADD-CASP10 complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 355|8772 -0.95179 0 141 0 0 -2.97821 18.44674 861 D 2047|420 EPHB1|M 8|5081|10 EF2C|PAX GO 324|2706 7|KLHL41| GO:00359 1 -3.08643 M1 1 0 Biological 19 skeletal muscle cell differentiation -3.08643 3.609144 4.202642 24156 69 873 9 1.030928 0.341867 3|30812|5 ANKRD1| -1.41938 0 124 0 0 -3.22859 6.58812 14 Processes 7486|936 SOX8|NL 49|64265 N|MYOC 8 D|SCX ADORA2 A|AGTR2| 135|186|9 CD34|CD 47|983|18 K1|ECT2|S 94|2040|3 TOM|HTR 357|4155| 2B|MBP|P 5116|517 CNT|PDZ 4|5366|56 K1|PMAIP 00|7029|8 1|MAPK1 111|8767| 1|TFDP2| 9585|966 GPR68|RI GO GO:19049 positive regulation of establishment of 2|10125|1 PK2|KIF20 1 -3.08066 M1 1 0 Biological 19 -3.08066 1.848649 3.574189 24156 464 873 31 3.550974 0.626348 -1.41436 0 133 1 1 -3.08066 2.143459 51 protein localization 0631|230 B|CEP135| Processes 86|23379| RASGRP1| 27063|28 POSTN|E 984|5151 XPH5|ICE 2|55835|7 1|ANKRD 9679|801 1|RGCC|G 84|84455| TSE1|CEN 85459|94 PJ|VTCN1 121|1148 |CEP290|E 99 FCAB7|CE P295|SYT L4|C1QT ACTL6A|P RDM1|B 86|639|65 MP7|BRC 5|675|210 A2|ESRRB 3|3280|39 |HES1|LIF| 76|4089|4 SMAD4|N 751|5156| EK2|PDGF 6491|649 RA|STIL|S 8|6692|70 KIL|SPINT GO 75|9133|9 GO:00017 1|TIE1|CC 1 -3.0647 M1 1 0 Biological 19 in utero embryonic development -3.0647 1.940501 3.60211 24156 385 873 27 3.092784 0.58593 508|1045 -1.40441 0 26 0 0 -6.76747 2.184482 01 NB2|ADA Processes 4|10733|2 MTS3|TA 3414|270 B1|PLK4|Z 22|30812| FPM2|FO 51294|54 XD3|SOX 892|5771 8|PCDH1 8|144455| 2|NCAPG 157506|3 2|PPP4R4| 38596 E2F7|RDH 10|ST8SIA GO 10733|55 PLK4|CEN GO:00466 1 -3.06206 M1 1 0 Biological 19 positive regulation of centriole replication -3.06206 13.83505 6.088437 24156 6 873 3 0.343643 0.198061 835|8545 PJ|CEP29 -1.40441 0 19 0 0 -7.81934 13.83505 01 Processes 9 5 GO GO:00012 RNA polymerase II transcription coactivator 1385|477 CREB1|NF 1 -2.41795 M1 1 0 Molecular 21 -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 178 0 0 -2.59562 18.44674 25 binding 2 ATC1 Functions GO 9508|576 ADAMTS GO:19007 positive regulation of vascular endothelial 1 -3.06206 M1 1 0 Biological 19 -3.06206 13.83505 6.088437 24156 6 873 3 0.343643 0.198061 08|14737 3|JCAD|C -1.40441 0 62 0 0 -4.52156 13.83505 48 growth factor signaling pathway Processes 2 CBE1 GO GO:00317 1907|190 EDN2|ED 1 -2.41795 M1 1 0 Molecular 21 endothelin B receptor binding -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 187 0 0 -2.48174 18.44674 08 8 N3 Functions CORUM:4 5395|915 PMS2|EX 1 -2.41795 M1 1 0 CORUM 33 EXO1-MLH1-PMS2 complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 192 0 0 -2.41795 18.44674 15 6 O1 CORUM:4 5395|915 PMS2|EX 1 -2.41795 M1 1 0 CORUM 33 EXO1-MLH1-PMS2 complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 192 1 1 -2.41795 18.44674 23 6 O1 CORUM:6 S1PR1-c-Met-ITGB4 complex, HGF- or 3691|423 ITGB4|ME 1 -2.41795 M1 1 0 CORUM 33 -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 193 1 1 -2.41795 18.44674 798 S1P-induced 3 T CORUM:6 2890|103 GRIA1|CA 1 -2.41795 M1 1 0 CORUM 33 Stargazin-Glu1-mu2 complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 194 1 1 -2.41795 18.44674 196 69 CNG2 CORUM:6 2890|103 GRIA1|CA 1 -2.41795 M1 1 0 CORUM 33 Stargazin-Glu1-mu3 complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 194 0 0 -2.41795 18.44674 197 69 CNG2 GO GO:00361 145482|2 PTGR2|ZA 1 -2.41795 M1 1 0 Molecular 21 13-prostaglandin reductase activity -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 195 0 0 -2.41795 18.44674 32 84273 DH2 Functions GO GO:00475 145482|2 PTGR2|ZA 1 -2.41795 M1 1 0 Molecular 21 15-oxoprostaglandin 13-oxidase activity -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 195 1 1 -2.41795 18.44674 22 84273 DH2 Functions CORUM:6 1003|232 CDH5|FLT 1 -2.41795 M1 1 0 CORUM 33 VEcad-VEGFR complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 196 1 1 -2.41795 18.44674 586 4 4 CORUM:3 4089|649 SMAD4|S 1 -2.41795 M1 1 0 CORUM 33 SMAD4-SNO-SKI complex -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 197 1 1 -2.41795 18.44674 197 8 KIL GO GO:00009 assembly of actomyosin apparatus involved 1894|949 ECT2|KIF2 1 -3.06206 M1 1 0 Biological 19 -3.06206 13.83505 6.088437 24156 6 873 3 0.343643 0.198061 -1.40441 0 102 0 0 -3.49473 18.44674 12 in cytokinesis 3|54443 3|ANLN Processes GO GO:00009 1894|949 ECT2|KIF2 1 -3.06206 M1 1 0 Biological 19 actomyosin contractile ring assembly -3.06206 13.83505 6.088437 24156 6 873 3 0.343643 0.198061 -1.40441 0 102 0 0 -3.49473 18.44674 15 3|54443 3|ANLN Processes CDKN2B|I 1030|362 NHBA|SM 4|4089|40 AD4|SMA 90|6498|7 R-HSA- Reactome D5|SKIL|T 1 -2.41554 M1 1 0 6 Signaling by TGF-beta family members -2.41554 2.712755 3.356548 24156 102 873 10 1.145475 0.360151 029|1046 -0.95032 0 136 0 0 -3.0513 3.816566 9006936 Gene Sets FDP2|FST| 8|56937|6 PMEPA1| 4750|918 SMURF2| 51 CHRDL1 ACTN2|A DORA2A| CAMK2A| 88|135|81 CDH10|C 5|1008|11 HRM3|CH 31|1134|1 RNA1|CN 266|1600| N3|DAB1| 2556|255 GABRA3| 7|2890|29 GABRA4| GO 02|2913|3 GRIA1|GR GO:00995 Cellular 1 -2.41321 M1 1 0 20 postsynaptic specialization -2.41321 1.814433 3.040114 24156 366 873 24 2.749141 0.553399 838|7074| IN1|GRM -0.94891 0 58 0 0 -4.67369 3.739203 72 Compone 8537|103 3|KPNA2| nts 69|11346| TIAM1|BC 22871|23 AS1|CAC 237|2603 NG2|SYN 7|57537|8 PO|NLGN 4687|347 1|ARC|SIP 730 A1L1|SOR CS2|PPP1 R9B|LRRT M1 GO BHMT|D GO:00424 635|2995 1 -3.06206 M1 1 0 Biological 19 choline catabolic process -3.06206 13.83505 6.088437 24156 6 873 3 0.343643 0.198061 MGDH|C -1.40441 0 134 0 0 -3.06206 27.6701 26 8|55349 Processes HDH GO GO:00061 2618|547 GART|PP 1 -3.06206 M1 1 0 Biological 19 'de novo' IMP biosynthetic process -3.06206 13.83505 6.088437 24156 6 873 3 0.343643 0.198061 -1.40441 0 135 0 0 -3.06206 13.83505 89 1|10606 AT|PAICS Processes VCAN|FG 1462|224 F2|HMMR 7|3161|40 |LUM|OG 60|4969|7 GO N|UGDH| GO:19035 358|1108 1 -3.06141 M1 1 0 Biological 19 mucopolysaccharide metabolic process -3.06141 2.912642 3.963621 24156 114 873 12 1.37457 0.394068 KERA|CH -1.40441 0 96 0 0 -3.66151 10.37629 10 1|51363|5 Processes ST15|CSG 5790|807 ALNACT1 60|93010| |ITIH5|B3 133584 GNT7|EG BMP7|FZ 655|2535| D2|HES1| 3280|508 PAX7|PR 1|5629|64 OX1|SFRP 22|6491|6 1|STIL|SPI GO GO:00219 692|8543| NT1|LMO 1 -3.06054 M1 1 0 Biological 19 neural tube development -3.06054 2.546329 3.835698 24156 163 873 15 1.718213 0.439813 -1.40441 0 64 0 0 -4.46525 3.120688 15 8854|958 4|ALDH1 Processes 5|51098|5 A2|KIF20B 7619|131 |IFT52|SH 405|1441 ROOM3|T 65 RIM71|PR ICKLE1 2239|491 GPC4|NT GO 6|11141|2 RK3|IL1R GO:19056 1 -3.05203 M1 1 0 Biological 19 regulation of presynapse assembly -3.05203 5.188144 4.590533 24156 32 873 6 0.687285 0.279617 2871|262 APL1|NLG -1.39661 0 63 0 0 -4.50244 10.37629 06 Processes 80|34773 N1|IL1RA 0 PL2|LRRT 2247|227 FGF2|VEG 7|3673|39 FD|ITGA2| GO GO:00509 58|4233|4 LGALS3| 1 -3.04056 M1 1 0 Biological 19 positive chemotaxis -3.04056 3.557585 4.149425 24156 70 873 9 1.030928 0.341867 -1.38861 0 137 1 1 -3.04056 10.37629 18 916|5228| MET|NTR Processes 5795|638 K3|PGF|P 7 TPRJ|CXC CHRNA1| GABRA2| 1134|255 GO neurotransmitter receptor activity involved GABRA3| GO:00995 5|2556|25 1 -2.40856 M1 1 0 Molecular 21 in regulation of postsynaptic membrane -2.40856 3.458763 3.56692 24156 56 873 7 0.801833 0.301847 GABRA4| -0.94748 0 112 0 0 -3.34087 10.06186 29 57|2565|2 Functions potential GABRG1| 890|2902 GRIA1|GR IN1 1894|905 ECT2|PST GO 1|10733|5 PIP1|PLK4 GO:00321 Cellular 1 -2.40856 M1 1 0 20 cleavage furrow -2.40856 3.458763 3.56692 24156 56 873 7 0.801833 0.301847 4820|551 |NDE1|CE -0.94748 0 168 0 0 -2.68133 3.458763 54 Compone 65|83872| P55|HMC nts 84930 N1|MAST BRCA2|C 675|835|1 ASP2|COL 299|2491| 9A3|CEN 2620|362 PI|GAS2|I 4|4089|40 NHBA|SM 90|5156|6 AD4|SMA 422|7022| D5|PDGF GO GO:00075 8743|101 RA|SFRP1 1 -3.04046 M1 1 0 Biological 19 sex differentiation -3.04046 2.144178 3.667809 24156 271 873 21 2.405498 0.518571 -1.38861 0 89 0 0 -3.75072 2.95506 48 84|10468| |TFAP2C| Processes 23414|23 TNFSF10| 598|3081 LHFPL2|F 2|81930|1 ST|ZFPM2 57506|25 |PATZ1|S 9266|642 OX8|KIF1 658 8A|RDH1 0|ASPM|S 655|2103| BMP7|ES 2247|328 RRB|FGF2 0|3976|40 |HES1|LIF| 17|4089|5 LOXL2|S GO GO:00987 629|6422| MAD4|PR 1 -3.03328 M1 1 0 Biological 19 maintenance of cell number -3.03328 2.530802 3.808894 24156 164 873 15 1.718213 0.439813 -1.38214 0 10 0 0 -10.1376 3.952872 27 10413|10 OX1|SFRP Processes 736|2702 1|YAP1|SI 2|55183|7 X2|FOXD 9648|259 3|RIF1|M 266 CPH1|AS SERPINE2 GO 5270|562 GO:00216 |PROX1|KI 1 -3.03021 M1 1 0 Biological 19 cerebellar granular layer development -3.03021 8.513878 5.247245 24156 13 873 4 0.45819 0.22857 9|9928|85 -1.38119 0 92 0 0 -3.73382 12.29782 81 F14|KND Processes 442 C1 1600|328 DAB1|HE GO 0|5270|56 S1|SERPI GO:00215 1 -3.02822 M1 1 0 Biological 19 hindbrain morphogenesis -3.02822 4.402062 4.373641 24156 44 873 7 0.801833 0.301847 29|6095|9 NE2|PRO -1.38015 0 92 0 0 -3.73382 12.29782 75 Processes 928|8544 X1|RORA| 2 KIF14|KN PRDM1|F 639|2535| ZD2|HES1 3280|405 |LTBP1|S 2|4089|42 MAD4|M GO GO:00032 08|5629|7 EF2C|PRO 1 -3.02705 M1 1 0 Biological 19 cardiac ventricle development -3.02705 2.745888 3.87982 24156 131 873 13 1.489118 0.40992 -1.38015 0 75 0 0 -4.23321 3.816566 31 135|7139| X1|TNNI1 Processes 8543|234 |TNNT2|L 14|54567| MO4|ZFP 93649 M2|DLL4| MYOCD ACTC1|S GO 70|4089|5 GO:00550 MAD4|PD 1 -3.01725 M1 1 0 Biological 19 cardiac myofibril assembly -3.01725 6.28866 4.805444 24156 22 873 5 0.572738 0.255402 156|5629| -1.37315 0 13 0 0 -9.83559 6.28866 03 GFRA|PR Processes 10529 OX1|NEB CDH9|EP 1007|204 HB1|EPH 7|2048|22 B2|GPC4| 39|2555|2 GABRA2| 902|4208| GRIN1|M GO 4916|705 EF2C|NTR GO:00074 1 -3.01178 M1 1 0 Biological 19 synapse assembly -3.01178 2.432537 3.756318 24156 182 873 16 1.832761 0.453972 8|9423|11 K3|THBS2 -1.36907 0 63 0 0 -4.50244 10.37629 16 Processes 141|2287 |NTN1|IL1 1|23768|2 RAPL1|NL 6280|546 GN1|FLRT 74|34773 2|IL1RAPL 0 2|LRRN3| LRRTM1 ACTN2|A 88|135|18 DORA2A| 6|815|139 AGTR2|C 3|1908|20 AMK2A|C 40|2048|2 RHBP|ED 273|2824| N3|STOM 2890|290 |EPHB2|F 2|3690|37 HL1|GPM 39|3759|3 6B|GRIA1| 762|3958| GRIN1|IT 4208|517 GB3|KCN 4|5270|55 A4|KCNJ2 93|6328|6 |KCNJ5|L GO 387|7057| GALS3|M GO:00432 1 -3.00263 M1 1 0 Biological 19 regulation of ion transport -3.00263 1.660206 3.43236 24156 700 873 42 4.810997 0.724275 7852|910 EF2C|PDZ -1.36131 0 45 0 0 -5.5147 9.223368 69 Processes 4|9312|10 K1|SERPI 369|1089 NE2|PRK 1|10991|2 G2|SCN3 2871|232 A|CXCL12 37|27133| |THBS1|C 54997|57 XCR4|RG 165|8103 N|KCNB2| 3|84329|1 CACNG2| 17531|12 PPARGC1 6755|128 A|SLC38A 414|1965 3|NLGN1| 27|72923 ARC|KCN 0 H5|TESC| GJC2|KCN CCND2|C 894|899|9 CNF|CCN GO 01|983|10 G2|CDK1| GO:19029 Cellular 21|1164|9 CDK6|CKS 1 -2.38511 M1 1 0 20 protein kinase complex -2.38511 2.686418 3.321164 24156 103 873 10 1.145475 0.360151 -0.92858 0 37 0 0 -6.01116 5.929308 11 Compone 133|9134| 2|CCNB2| nts 85417|15 CCNE2|C 2110 CNB3|NE K10 AGTR2|C RABP2|FH L1|FN1|G 186|1382| OLGA4|IN 2273|233 HBA|SMA 5|2803|36 D4|NTRK 24|4089|4 3|ENPP1| 916|5167| SERPINE2 5270|579 |PTPRJ|RB 5|5931|63 BP7|CXCL 87|6422|6 12|SFRP1| 456|6790| GO SH3GL2|A GO:00160 7074|785 1 -2.99741 M1 1 0 Biological 19 cell growth -2.99741 1.807027 3.49474 24156 490 873 32 3.665521 0.635992 URKA|TIA -1.35717 0 104 0 0 -3.44559 2.082696 49 2|9423|97 Processes M1|CXCR 23|9928|1 4|NTN1|S 0276|105 EMA3E|KI 16|10631| F14|NET1| 26153|29 FBLN5|PO 948|5443 STN|KIF2 7|55031|8 6A|OSGI 4687|850 N1|SEMA 04|93649| 5B|USP47 151835 |PPP1R9B |RERG|MY OCD|CPN CCND2|C 894|899|9 CNF|CCN GO 01|983|10 G2|CDK1| GO:19025 Cellular 1 -2.37912 M1 1 0 20 serine/threonine protein kinase complex -2.37912 2.862424 3.369771 24156 87 873 9 1.030928 0.341867 21|1164|9 CDK6|CKS -0.92439 0 37 0 0 -6.01116 5.929308 54 Compone 133|9134| 2|CCNB2| nts 85417 CCNE2|C CNB3 BRCA2|C 675|835|1 ASP2|COL 299|2620| 9A3|GAS2 3624|408 |INHBA|S 9|5156|64 MAD4|PD 22|7022|8 GFRA|SFR GO GO:00084 743|1046 P1|TFAP2 1 -2.9971 M1 1 0 Biological 19 gonad development -2.9971 2.284687 3.689546 24156 218 873 18 2.061856 0.480948 -1.35717 0 89 0 0 -3.75072 2.95506 06 8|23414|2 C|TNFSF1 Processes 3598|308 0|FST|ZFP 12|81930| M2|PATZ 157506|2 1|SOX8|KI 59266|64 F18A|RD 2658 H10|ASP M|SCX MRE11|P 4361|507 ARN|ENP 3|5167|51 GO P1|ENPP3 GO:00045 69|9156|9 1 -2.37912 M1 1 0 Molecular 21 exonuclease activity -2.37912 2.862424 3.369771 24156 87 873 9 1.030928 0.341867 |EXO1|DC -0.92439 0 188 0 0 -2.46134 6.917526 27 937|5446 Functions LRE1A|XR 4|92667|1 N1|MGM 15752 E1|DIS3L ACTC1|CE 70|1062|3 NPE|KIF1 832|4175| 1|MCM6| 5395|713 PMS2|TN 9|7140|71 NT2|TNN 53|8458|9 T3|TOP2A 493|9585| |TTF2|KIF 9928|103 23|KIF20B GO 51|11004| GO:00168 |KIF14|AB 1 -2.37823 M1 1 0 Molecular 21 ATPase activity -2.37823 1.778284 2.996519 24156 389 873 25 2.863688 0.564477 11104|24 -0.92439 0 46 0 0 -5.44351 7.281606 87 CA8|KIF2 Functions 137|2615 C|KATNA 3|53904|5 1|KIF4A|KI 4821|551 F26A|MY 37|79075| O3A|ERC 80119|81 C6L|FIGN| 930|3472 DSCC1|PI 40|40172 F1|KIF18A 0 |KIF24|FIG PRDM1|D 639|1600| AB1|HES1 3280|512 |PCSK5|P 5|5156|64 DGFRA|SF GO 22|6425|8 GO:00485 RP1|SFRP 1 -2.9963 M1 1 0 Biological 19 digestive tract development -2.9963 2.725086 3.848276 24156 132 873 13 1.489118 0.40992 854|1073 -1.35706 0 139 1 1 -2.9963 4.069133 65 5|ALDH1 Processes 6|56034|9 A2|SIX2|P 1461|936 DGFC|PK 49|33982 DCC|MY 9 OCD|CCD ACTC1|A 70|87|88| CTN1|AC 2620|745 TN2|GAS GO 6|9645|23 2|WIPF1| GO:00058 Cellular 1 -2.37793 M1 1 0 20 actin filament -2.37793 2.536426 3.2671 24156 120 873 11 1.260023 0.37751 433|2729 MICAL2|R -0.92439 0 200 1 1 -2.37793 2.536426 84 Compone 5|53904|9 HOQ|PDL nts 2521|246 IM3|MYO 176 3A|SPECC 1|GAS2L2 2239|491 GPC4|NT GO 6|11141|2 RK3|IL1R GO:00991 1 -2.97821 M1 1 0 Biological 19 regulation of presynapse organization -2.97821 5.030928 4.486808 24156 33 873 6 0.687285 0.279617 2871|262 APL1|NLG -1.34172 0 63 0 0 -4.50244 10.37629 74 Processes 80|34773 N1|IL1RA 0 PL2|LRRT ASPA|GP 443|2840| R17|HES1 3280|535 |PLP1|TNF GO 4|7133|72 GO:00487 RSF1B|TR 1 -2.97411 M1 1 0 Biological 19 oligodendrocyte differentiation -2.97411 3.013576 3.926604 24156 101 873 11 1.260023 0.37751 23|7852|8 -1.33831 0 56 0 0 -4.84716 6.385408 09 PC4|CXC Processes 726|3081 R4|EED|S 2|83933|8 OX8|HDA 5414 C10|SLC4 GABRA2| GO 2555|255 GO:00048 GABRA3| 1 -2.37114 M1 1 0 Molecular 21 GABA-A receptor activity -2.37114 5.825285 4.074265 24156 19 873 4 0.45819 0.22857 6|2557|25 -0.91957 0 112 0 0 -3.34087 10.06186 90 GABRA4| Functions 65 GABRG1 GABRA2| GO 2555|255 GO:00990 GABRA3| 1 -2.37114 M1 1 0 Molecular 21 ligand-gated anion channel activity -2.37114 5.825285 4.074265 24156 19 873 4 0.45819 0.22857 6|2557|25 -0.91957 0 112 0 0 -3.34087 10.06186 95 GABRA4| Functions 65 GABRG1 GO 2047|204 EPHB1|EP GO:00050 1 -2.37114 M1 1 0 Molecular 21 ephrin receptor activity -2.37114 5.825285 4.074265 24156 19 873 4 0.45819 0.22857 8|4916|28 HB2|NTR -0.91957 0 126 0 0 -3.20893 9.223368 03 Functions 4656 K3|EPHA1 COL5A1| 1289|129 COL7A1| GO GO:00359 4|1295|23 COL8A1|F 1 -2.96836 M1 1 0 Biological 19 endodermal cell differentiation -2.96836 4.304238 4.295969 24156 45 873 7 0.801833 0.301847 -1.3346 0 77 0 0 -4.11211 18.44674 87 35|3624|3 N1|INHB Processes 909|3914 A|LAMA3| LAMB3 BRCA1|C 672|1490| GO CN2|RBB GO:00703 5931|624 1 -2.96836 M1 1 0 Biological 19 regulation of G0 to G1 transition -2.96836 4.304238 4.295969 24156 45 873 7 0.801833 0.301847 P7|RRM2| -1.3346 0 142 1 1 -2.96836 11.06804 16 1|7029|83 Processes TFDP2|CD 17|8726 C7|EED BRCA1|BR 672|675|8 CA2|CAS 35|983|30 P2|CDK1| 90|5366|6 GO HIC1|PM GO:00427 signal transduction in response to DNA 790|7029| 1 -2.9659 M1 1 0 Biological 19 -2.9659 2.704597 3.817025 24156 133 873 13 1.489118 0.40992 AIP1|AUR -1.33283 0 30 0 0 -6.32789 4.035223 70 damage 27063|28 Processes KA|TFDP2 984|5151 |ANKRD1| 2|51514|1 RGCC|GT 44455 SE1|DTL|E AGTR2|B MP7|CYP 186|655|1 1B1|EDN3 545|1908| |FGF2|FLT 2247|232 4|FN1|HT 4|2335|33 R2B|ITGA 57|3673|3 2|ITGB3|L 690|4017| OXL2|ME 4208|423 F2C|MET| 3|4902|51 NRTN|PE GO 75|5308|5 GO:00016 CAM1|PIT 1 -2.96118 M1 1 0 Biological 19 ameboidal-type cell migration -2.96118 1.817316 3.47236 24156 472 873 31 3.550974 0.626348 587|5629| -1.32947 0 15 0 0 -9.08083 2.73285 67 X2|PRKD1 Processes 6915|705 |PROX1|T 7|9723|28 BXA2R|T 984|2994 HBS1|SE 1|30812|5 MA3E|RG 4443|545 CC|PKN3| 67|57381| SOX8|AN 57608|64 LN|DLL4| 750|7981 RHOJ|JCA 2|147372 D|SMURF 2|MMRN ADORA2 B|FAS|BM P7|CDKN 136|355|6 2B|COMT 55|1030|1 |CREB1|C 312|1385| YP24A1|D 1591|178 NMT3B|G 9|2902|36 RIN1|ITG 73|4316|5 A2|MMP7 179|5366| |PENK|PM 5563|558 AIP1|PRK 7|5629|64 AA2|PRK 22|6915|7 D1|PROX GO GO:00099 054|8854| 1|SFRP1|T 1 -2.95972 M1 1 0 Biological 19 response to extracellular stimulus -2.95972 1.761767 3.446875 24156 534 873 34 3.894616 0.654786 -1.32868 0 50 0 0 -5.25088 2.470545 91 9388|106 BXA2R|T Processes 31|10891| H|ALDH1 10991|26 A2|LIPG|P 153|8001 OSTN|PP 0|81788|8 ARGC1A| 4687|936 SLC38A3| 49|14368 KIF26A|R 6|154743| MI1|NUA 389400|4 K2|PPP1R 40738|65 9B|MYOC 2968 D|SESN3| BMT2|GF RAL|MAP 1LC3C|CA PRDM1|B 639|655|6 MP7|BRC 75|835|89 A2|CASP2 9|1299|21 |CCNF|CO 03|2491|2 L9A3|ESR 620|3280| RB|CENPI| 3624|397 GAS2|HES 6|4089|40 1|INHBA| 90|5156|5 LIF|SMAD 270|6422| 4|SMAD5| 6692|679 PDGFRA| 0|7022|87 SERPINE2 43|9319|1 |SFRP1|SP GO 0184|104 INT1|AUR GO:00030 developmental process involved in 1 -2.9488 M1 1 0 Biological 19 -2.9488 1.661016 3.393356 24156 683 873 41 4.696449 0.716032 68|10733| KA|TFAP2 -1.31844 0 89 0 0 -3.75072 2.95506 06 reproduction Processes 23213|23 C|TNFSF1 414|2359 0|TRIP13| 8|30812|5 LHFPL2|F 1294|570 ST|PLK4|S 82|58494| ULF1|ZFP 81930|84 M2|PATZ 687|8531 1|SOX8|P 5|93649|1 CDH12|K 35138|14 NL1|JAM 4455|157 2|KIF18A| 506|2592 PPP1R9B| 66|64265 PAQR8|M 8 YOCD|PA CRG|E2F7 XIAP|BIRC 5|FAS|CA 331|332|3 SP2|LMN 55|835|40 B1|PMAIP 01|5366|5 KEGG 1|PTPN13 1 -2.3589 hsa04210 M1 1 0 24 Apoptosis -2.3589 2.406096 3.207578 24156 138 873 12 1.37457 0.394068 783|7132| -0.91068 0 141 0 0 -2.97821 18.44674 Pathway |TNFRSF1 8743|877 A|TNFSF1 2|79861|8 0|FADD|T 4823 UBAL3|L MNB2 DAB1|ECT 2|EPHB2| FGF2|GPR 1600|189 17|LPAR4| 4|2048|22 MET|PEC 47|2840|2 AM1|PRK 846|4233| D1|MAPK 5175|558 11|TIAM1 7|5600|70 |CTNNAL 74|8727|9 1|NTN1|A 423|9824| RHGAP11 9928|993 A|KIF14|A 8|10125|1 RHGAP25 0276|228 GO |RASGRP1 GO:00072 00|22821| 1 -2.94443 M1 1 0 Biological 19 small GTPase mediated signal transduction -2.94443 1.741823 3.426675 24156 556 873 35 4.009164 0.663949 |NET1|RR -1.31474 0 145 1 1 -2.94443 4.19244 64 23433|25 Processes AS2|RASA 780|2603 3|RHOQ| 7|26084|5 RASGRP3| 0650|517 SIPA1L1| 15|55789| ARHGEF2 57381|57 6|ARHGE 568|8495 F3|RAB23| 2|85004|8 DEPDC1B 5442|117 |RHOJ|SIP 178|1572 A1L2|CG 85|40125 NL1|RERG 8 |KNDC1|S SX2IP|PR AG1|RAB CCN2|EC 1490|189 T2|SMAD 4|4089|42 4|MEF2C| GO 08|4233|5 GO:01100 regulation of actomyosin structure MET|PRO 1 -2.93866 M1 1 0 Biological 19 -2.93866 2.984031 3.888177 24156 102 873 11 1.260023 0.37751 629|6422| -1.31033 0 14 0 0 -9.68163 3.166231 20 organization X1|SFRP1| Processes 22843|22 PPM1E|LI 998|2898 MCH1|RG 4|84952 CC|CGNL CCND2|C 894|899|9 CNF|CCN 01|1030|1 G2|CDKN GO 164|5629| 2B|CKS2| GO:00000 regulation of cyclin-dependent protein 1 -2.93866 M1 1 0 Biological 19 -2.93866 2.984031 3.888177 24156 102 873 11 1.260023 0.37751 9133|913 PROX1|C -1.31033 0 37 0 0 -6.01116 5.929308 79 serine/threonine kinase activity Processes 4|28984|8 CNB2|CC 5417|936 NE2|RGC 49 C|CCNB3| MYOCD BMP7|IN 655|3624| HBA|ITGA 3673|369 2|ITGB3|I 0|3691|40 GO TGB4|SM GO:00074 89|6939|7 1 -2.93585 M1 1 0 Biological 19 mesoderm development -2.93585 2.684413 3.786061 24156 134 873 13 1.489118 0.40992 AD4|TCF1 -1.30819 0 146 1 1 -2.93585 3.952872 98 075|7296| Processes 5|TIE1|TX 10413|10 NRD1|YA 736|2341 P1|SIX2|Z 4|642658 FPM2|SC 2491|593 CENPI|RB 1|23421|5 BP7|ITGB GO GO:00434 5355|558 3BP|HJUR 1 -2.91289 M1 1 0 Biological 19 histone exchange -2.91289 3.751878 4.097934 24156 59 873 8 0.91638 0.322501 -1.28791 0 31 0 0 -6.31644 12.57732 86 39|57082| P|CENPN| Processes 91687|40 KNL1|CE 1541 NPL|CEN CD34|EP 947|2048| HB2|FGF2 2247|491 |NTRK3|P 6|5156|52 DGFRA|SE 70|6915|7 RPINE2|T GO 056|7057| GO:19030 BXA2R|T 1 -2.91193 M1 1 0 Biological 19 regulation of response to wounding -2.91193 2.380224 3.659006 24156 186 873 16 1.832761 0.453972 7852|569 -1.28762 0 108 0 0 -3.3802 5.825285 34 HBD|THB Processes 63|94121| S1|CXCR4 170692|1 |RGMA|SY 96527|21 TL4|ADA 9770|100 MTS18|A 506658 NO6|GJD ACTN2|C AMK2A|C HAT|CHR 88|815|11 NA1|CO 03|1134|1 MT|CREB 312|1385| 1|GABRA 2555|255 2|GABRA 6|2557|28 R-HSA- Reactome 3|GABRA 1 -2.34129 M1 1 0 6 Transmission across Chemical Synapses -2.34129 1.947155 3.030558 24156 270 873 19 2.176403 0.493838 90|2902|3 -0.89595 0 97 0 0 -3.64921 2.294594 112315 Gene Sets 4|GRIA1| 759|3762| GRIN1|KC 3838|556 NJ2|KCNJ 3|10369|2 5|KPNA2| 2843|798 PRKAA2| 61|81027 CACNG2| PPM1E|T UBAL3|TU ESRRB|FG 2103|224 F2|FZD2|I 7|2535|36 NHBA|LIF| 24|3976|4 SMAD4|S KEGG Signaling pathways regulating pluripotency 089|4090| 1 -2.33379 hsa04550 M1 1 0 24 -2.33379 2.388786 3.179615 24156 139 873 12 1.37457 0.394068 MAD5|M -0.8897 0 147 0 0 -2.92937 2.388786 Pathway of stem cells 5600|649 APK11|SK 8|8325|55 IL|FZD8|RI 183|8032 F1|WNT1 6 0A BRCA1|C 672|1490| GO CN2|RBB GO:00450 5931|624 1 -2.91022 M1 1 0 Biological 19 G0 to G1 transition -2.91022 4.210668 4.220529 24156 46 873 7 0.801833 0.301847 P7|RRM2| -1.28658 0 142 0 0 -2.96836 11.06804 23 1|7029|83 Processes TFDP2|CD 17|8726 C7|EED 672|835|9 BRCA1|C 83|6790|7 ASP2|CD GO GO:00724 signal transduction involved in DNA 029|2898 K1|AURK 1 -2.90825 M1 1 0 Biological 19 -2.90825 3.411383 3.995429 24156 73 873 9 1.030928 0.341867 -1.28593 0 30 0 0 -6.32789 4.035223 01 integrity checkpoint 4|51512|5 A|TFDP2| Processes 1514|144 RGCC|GT 455 SE1|DTL|E FANCB|F CORUM:6 2187|218 1 -2.33108 M1 1 0 CORUM 33 Fanconi anemia FAAP100 complex -2.33108 8.301031 4.471495 24156 10 873 3 0.343643 0.198061 ANCF|FA -0.8897 0 44 0 0 -5.52611 9.223368 884 8|91442 AP24 PRKAA2| R-HSA- Reactome Activation of PPARGC1A (PGC-1alpha) by 5563|560 1 -2.33108 M1 1 0 6 -2.33108 8.301031 4.471495 24156 10 873 3 0.343643 0.198061 MAPK11| -0.8897 0 90 0 0 -3.74989 8.301031 2151209 Gene Sets phosphorylation 0|10891 PPARGC1 672|835|9 BRCA1|C 83|6790|7 ASP2|CD GO GO:00724 signal transduction involved in DNA 029|2898 K1|AURK 1 -2.90825 M1 1 0 Biological 19 -2.90825 3.411383 3.995429 24156 73 873 9 1.030928 0.341867 -1.28593 0 30 0 0 -6.32789 4.035223 22 damage checkpoint 4|51512|5 A|TFDP2| Processes 1514|144 RGCC|GT 455 SE1|DTL|E Canonical 2277|232 VEGFD|FL 1 -2.33108 M137 M1 1 0 11 PID VEGF VEGFR PATHWAY -2.33108 8.301031 4.471495 24156 10 873 3 0.343643 0.198061 -0.8897 0 137 0 0 -3.04056 10.37629 Pathways 4|5228 T4|PGF AGTR2|B 186|655|2 MP7|FGF 247|3280| 2|HES1|S GO 4089|409 GO:00018 MAD4|S 1 -2.90372 M1 1 0 Biological 19 mesonephros development -2.90372 2.95506 3.850217 24156 103 873 11 1.260023 0.37751 0|5228|64 -1.2834 0 10 0 0 -10.1376 3.952872 23 MAD5|PG Processes 22|10736| F|SFRP1|S 30812|11 IX2|SOX8| 6039 OSR2 1062|383 CENPE|KI 2|6456|70 F11|SH3G 57|8655|9 L2|THBS1| GO antigen processing and presentation of GO:00025 493|1100 DYNLL1|K 1 -2.90372 M1 1 0 Biological 19 peptide or polysaccharide antigen via MHC -2.90372 2.95506 3.850217 24156 103 873 11 1.260023 0.37751 -1.2834 0 46 0 0 -5.44351 7.281606 04 4|24137|2 IF23|KIF2 Processes class II 6153|819 C|KIF4A|K 30|13034 IF26A|KIF 0 18A|AP1S BRCA2|C 675|835|1 ASP2|COL 299|2620| 9A3|GAS2 GO 3624|408 GO:00465 development of primary female sexual |INHBA|S 1 -2.90372 M1 1 0 Biological 19 -2.90372 2.95506 3.850217 24156 103 873 11 1.260023 0.37751 9|5156|64 -1.2834 0 89 0 0 -3.75072 2.95506 45 characteristics MAD4|PD Processes 22|10184| GFRA|SFR 10468|23 P1|LHFPL 414 2|FST|ZFP CDK1|CE 983|1063| NPF|CREB 1385|204 1|EPHB1| 7|2247|40 FGF2|SM GO 89|4208|5 GO:00162 regulation of striated muscle tissue AD4|MEF 1 -2.89801 M1 1 0 Biological 19 -2.89801 2.548562 3.708513 24156 152 873 14 1.603666 0.425147 600|7093| -1.28286 0 117 0 0 -3.28848 6.510612 02 development 2C|MAPK Processes 10324|10 11|TLL2|K 413|2341 LHL41|YA 4|57486|9 P1|ZFPM 3649 2|NLN|M AGTR2|B 186|635|9 HMT|CD3 47|1103|1 4|CHAT|C 312|1545| OMT|CYP GO 2618|609 GO:00421 1B1|GART 1 -2.89801 M1 1 0 Biological 19 neurotransmitter metabolic process -2.89801 2.548562 3.708513 24156 152 873 14 1.603666 0.425147 5|7054|91 -1.28286 0 148 1 1 -2.89801 2.548562 33 |RORA|TH Processes 04|26002| |RGN|MO 29958|55 XD1|DMG 349|2856 DH|CHD 71 H|RNF180 GO 672|899|4 BRCA1|C GO:00466 1 -2.89663 M1 1 0 Biological 19 negative regulation of centrosome cycle -2.89663 7.905744 5.004711 24156 14 873 4 0.45819 0.22857 751|5689 CNF|NEK -1.28286 0 70 0 0 -4.32747 27.6701 06 Processes 0 2|MDM1 GO 3832|475 KIF11|NE GO:00071 1 -2.89663 M1 1 0 Biological 19 mitotic centrosome separation -2.89663 7.905744 5.004711 24156 14 873 4 0.45819 0.22857 1|6790|54 K2|AURK -1.28286 0 80 0 0 -4.01173 9.223368 00 Processes 820 A|NDE1 ALDH1A3 GO 220|1545| GO:00425 |CYP1B1| 1 -2.89663 M1 1 0 Biological 19 retinal metabolic process -2.89663 7.905744 5.004711 24156 14 873 4 0.45819 0.22857 8854|157 -1.28286 0 131 0 0 -3.08989 10.37629 74 ALDH1A2 Processes 506 |RDH10 GO 639|3976| PRDM1|LI GO:00607 1 -2.89663 M1 1 0 Biological 19 trophoblast giant cell differentiation -2.89663 7.905744 5.004711 24156 14 873 4 0.45819 0.22857 10733|14 F|PLK4|E2 -1.28286 0 149 1 1 -2.89663 7.905744 07 Processes 4455 F7 AGTR2|A HR|BRCA 186|196|6 1|CDK1|C 72|983|11 HRM3|SL 31|1317|1 C31A1|CR 393|1545| HBP|CYP1 1789|189 B1|DNMT 4|4208|42 3B|ECT2| 33|5471|5 MEF2C|M GO GO:00356 563|6422| ET|PPAT| 1 -2.88568 M1 1 0 Biological 19 cellular response to drug -2.88568 1.913358 3.456371 24156 376 873 26 2.978236 0.575317 -1.27527 0 150 1 1 -2.88568 1.913358 90 7054|785 PRKAA2|S Processes 2|8767|10 FRP1|TH| 276|1089 CXCR4|RI 1|22843|2 PK2|NET1 7063|544 |PPARGC 64|84687| 1A|PPM1 85397|65 E|ANKRD 2968 1|XRN1|P PP1R9B|R GS8|CAST BARD1|B 580|672|6 RCA1|BR 75|2187|4 CA2|FAN 175|4361| CB|MCM6 7520|831 |MRE11|X 7|8318|93 RCC5|CD GO 19|9937|5 C7|CDC4 GO:00063 1 -2.88482 M1 1 0 Biological 19 double-strand break repair -2.88482 2.128469 3.542461 24156 260 873 20 2.290951 0.50637 5010|551 5|TRIP13| -1.27527 0 54 0 0 -4.90339 3.029573 02 Processes 37|55183| DCLRE1A| 80010|11 PARPBP|F 9392|146 IGN|RIF1| 956|2543 RMI1|SFR 94|35349 1|EME1|M 7|401720 CM9|POL N|FIGNL2 CHRNA1| GABRA2| 1134|255 GO GABRA3| GO:00989 postsynaptic neurotransmitter receptor 5|2556|25 1 -2.32272 M1 1 0 Molecular 21 -2.32272 3.339495 3.454115 24156 58 873 7 0.801833 0.301847 GABRA4| -0.88656 0 112 0 0 -3.34087 10.06186 60 activity 57|2565|2 Functions GABRG1| 890|2902 GRIA1|GR IN1 GO GO:00506 regulation of homocysteine metabolic BHMT|CO 1 -2.8845 M1 1 0 Biological 19 -2.8845 27.6701 7.303589 24156 2 873 2 0.229095 0.161809 635|1312 -1.27527 0 134 0 0 -3.06206 27.6701 66 process MT Processes MRE11|P 4361|507 ARN|EXO GO exonuclease activity, active with either ribo- 3|9156|99 GO:00167 1|DCLRE1 1 -2.32272 M1 1 0 Molecular 21 or deoxyribonucleic acids and producing -2.32272 3.339495 3.454115 24156 58 873 7 0.801833 0.301847 37|54464| -0.88656 0 188 0 0 -2.46134 6.917526 96 A|XRN1| Functions 5'-phosphomon 92667|11 MGME1| 5752 DIS3L XIAP|BIRC 331|332|3 5|FAS|BR KEGG 55|672|13 CA1|SLC3 1 -2.32191 hsa01524 M1 1 0 24 Platinum drug resistance -2.32191 3.03234 3.367392 24156 73 873 8 0.91638 0.322501 -0.88619 0 141 0 0 -2.97821 18.44674 Pathway 17|5366|7 1A1|PMAI 153|8772 P1|TOP2 A|FADD GO GO:19904 6387|785 CXCL12|C 1 -2.8845 M1 1 0 Biological 19 response to ultrasound -2.8845 27.6701 7.303589 24156 2 873 2 0.229095 0.161809 -1.27527 0 151 1 1 -2.8845 27.6701 78 2 XCR4 Processes GO GO:20004 positive regulation of CD8-positive, alpha- 8772|729 FADD|CC 1 -2.8845 M1 1 0 Biological 19 -2.8845 27.6701 7.303589 24156 2 873 2 0.229095 0.161809 -1.27527 0 152 1 1 -2.8845 27.6701 51 beta T cell extravasation 230 R2 Processes GO GO:00721 BMP7|SM 1 -2.8845 M1 1 0 Biological 19 nephrogenic mesenchyme morphogenesis -2.8845 27.6701 7.303589 24156 2 873 2 0.229095 0.161809 655|4089 -1.27527 0 153 1 1 -2.8845 27.6701 34 AD4 Processes CMKLR1| 1240|190 EDN2|ED 7|1908|22 N3|VEGF 77|3673|3 D|ITGA2|L 958|5228| GALS3|PG GO 6387|705 F|CXCL12| GO:00026 1 -2.88293 M1 1 0 Biological 19 regulation of leukocyte migration -2.88293 2.294594 3.604457 24156 205 873 17 1.947308 0.467671 7|8772|95 THBS1|FA -1.27498 0 42 0 0 -5.75682 3.654542 85 Processes 47|58494| DD|CXCL 79148|83 14|JAM2| 483|1314 MMP28|P 50|19652 LVAP|CD 7|729230 200R1|AN O6|CCR2 BMP7|CD H11|CRA 655|1009| BP2|CREB 1382|138 1|DAB1|E 5|1600|20 PHB1|EP 47|2048|2 HB2|FN1| 335|2803| GOLGA4| 2902|408 GRIN1|S 9|4902|49 MAD4|NR 16|4974|6 TN|NTRK 387|6498| 3|OMG|C GO GO:00074 7074|785 XCL12|SKI 1 -2.87425 M1 1 0 Biological 19 axonogenesis -2.87425 1.794505 3.397262 24156 478 873 31 3.550974 0.626348 -1.26694 0 29 0 0 -6.42481 3.074456 09 2|9423|97 L|TIAM1| Processes 23|23768| CXCR4|N 26037|54 TN1|SEM 437|5581 A3E|FLRT 6|84570|8 2|SIPA1L1 4612|916 |SEMA5B| 24|91653| DOK5|CO 133584|2 L25A1|PA 84217|28 RD6B|NE 4656 XN|BOC|E GFLAM|L AMA1|EP ADORA2 A|AGTR2| XIAP|CAL 135|186|3 B2|CDH5| 31|794|10 CMKLR1| 03|1240|1 COMT|SL 312|1317| C31A1|CP 1356|181 |DRD5|ED 6|1907|19 N2|EDN3| 08|2247|2 FGF2|FTL| 512|2840| GPR17|LP 2846|289 AR4|GRIA 0|2902|32 1|GRIN1| 63|3357|3 GO HPX|HTR GO:00550 759|4089| 1 -2.87103 M1 1 0 Biological 19 metal ion homeostasis -2.87103 1.656892 3.333885 24156 668 873 40 4.581901 0.707671 2B|KCNJ2 -1.26436 0 94 0 0 -3.67332 2.548562 65 5156|634 Processes |SMAD4|P 1|6387|68 DGFRA|S 69|6915|7 CO1|CXC 223|7852| L12|TACR 9104|105 1|TBXA2R 90|11346| |TRPC4|C 22821|30 XCR4|RG 001|5155 N|SCGN|S 4|54757|5 YNPO|RA 5013|640 SA3|ERO1 72|26172 A|ACKR4| 9|729230 FAM20A| MCUB|CD H23|STEA 672|835|9 BRCA1|C 83|6790|7 ASP2|CD GO GO:00723 signal transduction involved in cell cycle 029|2898 K1|AURK 1 -2.86581 M1 1 0 Biological 19 -2.86581 3.365283 3.94588 24156 74 873 9 1.030928 0.341867 -1.26298 0 30 0 0 -6.32789 4.035223 95 checkpoint 4|51512|5 A|TFDP2| Processes 1514|144 RGCC|GT 455 SE1|DTL|E PRDM1|H 639|3280| ES1|LTBP 4052|562 GO 1|PROX1| GO:00359 9|10454|1 1 -2.86448 M1 1 0 Biological 19 aorta development -2.86448 3.689347 4.038696 24156 60 873 8 0.91638 0.322501 TAB1|AD -1.26227 0 154 1 1 -2.86448 3.797857 04 1174|545 Processes AMTS6|D 67|14416 LL4|PRICK 5 LE1 CASP2|C 835|894|9 CND2|CD 83|1021|1 K1|CDK6| 030|2273| CDKN2B| 6790|702 GO FHL1|AUR GO:20000 regulation of G1/S transition of mitotic cell 9|7465|83 1 -2.86331 M1 1 0 Biological 19 -2.86331 2.354902 3.611289 24156 188 873 16 1.832761 0.453972 KA|TFDP2 -1.26174 0 30 0 0 -6.32789 4.035223 45 cycle 18|9928|2 Processes |WEE1|CD 7085|289 C45|KIF14 84|51512| |MTBP|RG 57165|14 CC|GTSE1 4455 |GJC2|E2F BMP7|CH GB|CCN2| 655|1114| EDN2|ED 1490|190 N3|FBN1| 7|1908|22 FGF2|VEG 00|2247|2 FD|INHBA 277|3624| |LGALS3|L 3958|397 IF|NRTN| 6|4902|49 OGN|PEN 69|5179|5 K|PGF|PT GO 228|5744| GO:00480 HLH|CXC 1 -2.28902 M1 1 0 Molecular 21 receptor ligand activity -2.28902 1.671735 2.878431 24156 480 873 29 3.321879 0.606525 6387|874 -0.85759 0 21 0 0 -7.62485 2.171781 18 L12|TNFS Functions 3|9547|97 F10|CXCL 23|9966|2 14|SEMA 3768|299 3E|TNFSF 48|56034| 15|FLRT2| 80326|11 OSGIN1|P 2616|252 DGFC|W 995|4077 NT10A|C 38|72396 MTM7|FN 1 DC5|TAF A1|INS- BRCA1|C 672|947|1 D34|CDH 003|1545| 5|CYP1B1 2247|227 |FGF2|VE 7|5228|55 GFD|PGF| GO 87|6915|7 GO:00457 PRKD1|TB 1 -2.85999 M1 1 0 Biological 19 positive regulation of angiogenesis -2.85999 2.283455 3.582224 24156 206 873 17 1.947308 0.467671 057|7075| -1.25906 0 15 0 0 -9.08083 2.73285 66 XA2R|TH Processes 7852|102 BS1|TIE1| 66|51129| CXCR4|R 57381|57 AMP2|AN 608|1473 GPTL4|RH 72 OJ|JCAD| XIAP|FAS| R-HSA- Reactome 331|355|8 1 -2.28667 M1 1 0 6 Regulation of necroptotic cell death -2.28667 5.534021 3.927869 24156 20 873 4 0.45819 0.22857 TNFSF10| -0.85652 0 141 0 0 -2.97821 18.44674 5675482 Gene Sets 743|8772 FADD 1240|190 CMKLR1| 7|1908|22 EDN2|ED GO 77|5228|6 N3|VEGF GO:00026 1 -2.85614 M1 1 0 Biological 19 positive regulation of leukocyte chemotaxis -2.85614 3.109 3.859685 24156 89 873 10 1.145475 0.360151 387|7057| D|PGF|CX -1.25583 0 42 0 0 -5.75682 3.654542 90 Processes 9547|196 CL12|THB 527|7292 S1|CXCL1 30 4|ANO6|C 983|3015| CDK1|H2 8357|100 AZ1|H3C R-HSA- Reactome 51|10592| 10|SMC4| 1 -2.28586 M1 1 0 6 Condensation of Prophase Chromosomes -2.28586 2.991362 3.322088 24156 74 873 8 0.91638 0.322501 -0.85614 0 36 0 0 -6.06241 22.13608 2299718 Gene Sets 54892|79 SMC2|NC 648|6536 APG2|MC 04 PH1|H3C ACTN2|M 88|4208|5 EF2C|PRO GO GO:00452 629|7139| X1|TNNT 1 -2.85374 M1 1 0 Biological 19 sarcomere organization -2.85374 4.121079 4.147203 24156 47 873 7 0.801833 0.301847 -1.25532 0 13 0 0 -9.83559 6.28866 14 7140|103 2|TNNT3| Processes 24|27063 KLHL41|A NKRD1 655|2201| BMP7|FB GO 2824|420 N2|GPM6 GO:00701 positive regulation of biomineral tissue 1 -2.85374 M1 1 0 Biological 19 -2.85374 4.121079 4.147203 24156 47 873 7 0.801833 0.301847 8|91461|1 B|MEF2C| -1.25532 0 65 0 0 -4.41834 4.966429 69 development Processes 16039|19 PKDCC|O 6527 SR2|ANO ADORA2 135|983|1 A|CDK1|D GO GO:00140 816|2902| RD5|GRIN 1 -2.85374 M1 1 0 Biological 19 response to amine -2.85374 4.121079 4.147203 24156 47 873 7 0.801833 0.301847 -1.25532 0 123 0 0 -3.23644 5.764605 75 3673|705 1|ITGA2|T Processes 4|84687 H|PPP1R9 B COL9A3|I 1299|362 NHBA|SM 4|4089|51 AD4|PDG 56|6422|7 FRA|SFRP GO 022|8743| GO:00085 1|TFAP2C 1 -2.84773 M1 1 0 Biological 19 male gonad development -2.84773 2.62563 3.694841 24156 137 873 13 1.489118 0.40992 23414|23 -1.24994 0 89 0 0 -3.75072 2.95506 84 |TNFSF10| Processes 598|3081 ZFPM2|P 2|81930|2 ATZ1|SO 59266|64 X8|KIF18A 2658 |ASPM|SC CD34|EP 947|2048| HB2|FGF2 2247|515 |PDGFRA| 6|5270|69 SERPINE2 15|7056|7 GO |TBXA2R| GO:00610 057|7852| 1 -2.84358 M1 1 0 Biological 19 regulation of wound healing -2.84358 2.515464 3.6532 24156 154 873 14 1.603666 0.425147 THBD|TH -1.24642 0 108 0 0 -3.3802 5.825285 41 94121|17 Processes BS1|CXCR 0692|196 4|SYTL4|A 527|2197 DAMTS18 70|10050 |ANO6|GJ 6658 D4|OCLN CDK1|CR 983|1382| ABP2|CRE 1385|224 B1|FGF2|F 7|2307|23 OXS1|FN 35|2803|4 1|GOLGA GO GO:00486 positive regulation of developmental 208|4916| 4|MEF2C| 1 -2.83931 M1 1 0 Biological 19 -2.83931 2.342443 3.587657 24156 189 873 16 1.832761 0.453972 -1.24357 0 29 0 0 -6.42481 3.074456 39 growth 5629|638 NTRK3|PR Processes 7|7852|94 OX1|CXC 23|10413| L12|CXCR 23414|15 4|NTN1|Y 1835 AP1|ZFP M2|CPNE BRCA1|C 672|1385| REB1|HES Canonical 3280|515 1|PDGFR 1 -2.28131 M166 M1 1 0 11 PID ATF2 PATHWAY -2.28131 3.282894 3.399549 24156 59 873 7 0.801833 0.301847 -0.85457 0 206 1 1 -2.28131 3.282894 Pathways 6|5600|70 A|MAPK1 54|10891 1|TH|PPA RGC1A ADORA2 A|XIAP|BI RC5|FAS| 135|331|3 C4A|COL 32|355|72 7A1|CCN 0|1294|14 2|FN1|GRI 90|2335|2 N1|MBP|S 902|4155| ERPINE2| 5270|536 PMAIP1|S 6|6692|70 PINT1|TH 57|7078|7 GO BS1|TIMP GO:00525 079|7980| 1 -2.83738 M1 1 0 Biological 19 regulation of peptidase activity -2.83738 1.804572 3.37363 24156 460 873 30 3.436426 0.616528 3|TIMP4|T -1.24315 0 116 0 0 -3.2998 2.23146 47 8743|876 Processes FPI2|TNFS 7|8772|92 F10|RIPK2 32|9812|9 |FADD|PT 966|2315 TG1|DELE 1|55031|7 1|TNFSF1 9444|807 5|GRAMD 60|11716 4|USP47| 6|124857| BIRC7|ITI 140902 H5|WFIKK N1|WFIKK N2|R3HD ITGA2|PR 3673|556 GO KAA2|PO GO:00148 3|10631|1 1 -2.83533 M1 1 0 Biological 19 response to muscle activity -2.83533 5.764605 4.521963 24156 24 873 5 0.572738 0.255402 STN|PPA -1.24315 0 90 0 0 -3.74989 8.301031 50 0891|252 Processes RGC1A|F 995 NDC5 DRD5|GRI GO 1816|290 GO:00076 N1|SERPI 1 -2.83533 M1 1 0 Biological 19 mating behavior -2.83533 5.764605 4.521963 24156 24 873 5 0.572738 0.255402 2|5270|70 -1.24315 0 123 0 0 -3.23644 5.764605 17 NE2|TH|P Processes 54|84687 PP1R9B 7153|727 TOP2A|TT GO GO:00513 2|23397|8 K|NCAPH| 1 -2.83533 M1 1 0 Biological 19 meiotic chromosome separation -2.83533 5.764605 4.521963 24156 24 873 5 0.572738 0.255402 -1.24315 0 156 1 1 -2.83533 5.764605 07 0010|146 RMI1|EM Processes 956 E1 GO GO:00716 maintenance of protein location in 2200|220 FBN1|FBN 1 -2.83085 M1 1 0 Biological 19 -2.83085 11.85862 5.563718 24156 7 873 3 0.343643 0.198061 -1.24237 0 24 0 0 -7.35548 20.75258 94 extracellular region 1|4052 2|LTBP1 Processes VCAN|GP 1462|223 C4|HMM 9|3161|40 R|LUM|O 60|4969|9 GN|PAPS R-HSA- Reactome 1 -2.27051 M1 1 0 6 Glycosaminoglycan metabolism -2.27051 2.454606 3.144506 24156 124 873 11 1.260023 0.37751 061|9653| S1|HS2ST -0.8463 0 96 0 0 -3.66151 10.37629 1630316 Gene Sets 11081|51 1|KERA|C 363|5579 HST15|CS 0|93010 GALNACT 1|B3GNT7 GO 10051|10 SMC4|SM GO:00100 1 -2.83085 M1 1 0 Biological 19 meiotic chromosome condensation -2.83085 11.85862 5.563718 24156 7 873 3 0.343643 0.198061 592|2339 C2|NCAP -1.24237 0 36 0 0 -6.06241 22.13608 32 Processes 7 H GO GO:00448 1894|949 ECT2|KIF2 1 -2.83085 M1 1 0 Biological 19 actomyosin contractile ring organization -2.83085 11.85862 5.563718 24156 7 873 3 0.343643 0.198061 -1.24237 0 102 0 0 -3.49473 18.44674 37 3|54443 3|ANLN Processes GO TNFRSF1 GO:00033 regulation of extracellular matrix 7132|713 1 -2.83085 M1 1 0 Biological 19 -2.83085 11.85862 5.563718 24156 7 873 3 0.343643 0.198061 A|TNFRSF -1.24237 0 113 0 0 -3.34087 13.83505 30 constituent secretion 3|28984 Processes 1B|RGCC GO 1289|641 GO:00359 COL5A1|T 1 -2.83085 M1 1 0 Biological 19 tendon development -2.83085 11.85862 5.563718 24156 7 873 3 0.343643 0.198061 02|64265 -1.24237 0 159 1 1 -2.83085 13.83505 89 NMD|SCX Processes 8 CRHBP|D 1393|178 NMT3B|D 9|1816|29 GO RD5|GRIN GO:00723 02|5179|7 1 -2.82417 M1 1 0 Biological 19 response to anesthetic -2.82417 3.320412 3.897173 24156 75 873 9 1.030928 0.341867 1|PENK|TI -1.23631 0 123 0 0 -3.23644 5.764605 47 074|7852| Processes AM1|CXC 8772|846 R4|FADD| 87 PPP1R9B 332|3832| BIRC5|KIF 4751|949 11|NEK2| GO GO:00903 3|22974|2 KIF23|TPX 1 -2.81715 M1 1 0 Biological 19 mitotic spindle assembly -2.81715 3.628866 3.980715 24156 61 873 8 0.91638 0.322501 -1.23052 0 8 0 0 -11.3911 5.158833 07 4137|551 2|KIF4A|C Processes 25|12673 EP192|CC 1 SAP PRDM1|S 639|4089| MAD4|M GO 4208|477 EF2C|NFA GO:00031 1 -2.81715 M1 1 0 Biological 19 heart valve development -2.81715 3.628866 3.980715 24156 61 873 8 0.91638 0.322501 2|7132|71 TC1|TNFR -1.23052 0 113 0 0 -3.34087 13.83505 70 Processes 33|54567| SF1A|TNF 642658 RSF1B|DL L4|SCX CCND2|C 894|899|9 CNF|CCN 01|1030|1 G2|CDKN GO 164|5629| 2B|CKS2| GO:19040 regulation of cyclin-dependent protein 1 -2.80182 M1 1 0 Biological 19 -2.80182 2.871426 3.739032 24156 106 873 11 1.260023 0.37751 9133|913 PROX1|C -1.21702 0 37 0 0 -6.01116 5.929308 29 kinase activity Processes 4|28984|8 CNB2|CC 5417|936 NE2|RGC 49 C|CCNB3| MYOCD BMP7|FZ 655|2535| D2|SFRP1 6422|649 |STIL|SPIN GO 1|6692|85 T1|LMO4| GO:00018 1 -2.80182 M1 1 0 Biological 19 neural tube formation -2.80182 2.871426 3.739032 24156 106 873 11 1.260023 0.37751 43|9585|5 KIF20B|IF -1.21702 0 64 0 0 -4.46525 3.120688 41 Processes 1098|576 T52|SHR 19|13140 OOM3|TR 5|144165 IM71|PRI CKLE1 CDK1|H2 983|3015| AZ1|LMN 4001|835 B1|H3C10 7|9133|10 |CCNB2|S R-HSA- Reactome 051|1059 1 -2.26017 M1 1 0 6 Mitotic Prophase -2.26017 2.338319 3.097153 24156 142 873 12 1.37457 0.394068 MC4|SMC -0.84015 0 36 0 0 -6.06241 22.13608 68875 Gene Sets 2|54892|5 2|NCAPG 5706|796 2|NDC1| 48|84930| MCPH1| 653604 MASTL|H ALDH1A3 |BMP7|BR 220|655|6 CA2|CDO 75|1036|1 1|CREB1| 385|3280| HES1|IRF6 3664|367 |ITGA2|S 3|4089|42 MAD4|M 33|5156|5 ET|PDGFR 270|5308| A|SERPIN 5471|562 E2|PITX2| GO GO:00487 9|6422|67 PPAT|PR 1 -2.80098 M1 1 0 Biological 19 gland development -2.80098 1.815459 3.350442 24156 442 873 29 3.321879 0.606525 -1.21679 0 160 1 1 -2.80098 1.815459 32 90|8543|8 OX1|SFRP Processes 772|8854| 1|AURKA| 9104|913 LMO4|FA 3|9423|23 DD|ALDH 213|8016 1A2|RGN| 9|80326|1 CCNB2|N 44455|28 TN1|SULF 4217|339 1|CTC1|W 829 NT10A|E2 F7|LAMA 1|CCDC3 AGTR2|B MP7|DAB 186|655|1 1|GART|G 600|2618| RIN1|HES 2902|328 1|SERPIN GO 0|5270|56 GO:00309 E2|PROX1 1 -2.79026 M1 1 0 Biological 19 hindbrain development -2.79026 2.483214 3.598751 24156 156 873 14 1.603666 0.425147 29|6095|8 -1.20788 0 92 0 0 -3.73382 12.29782 02 |RORA|AL Processes 854|9928| DH1A2|KI 10891|80 F14|PPAR 184|8544 GC1A|CE 2 P290|KN DC1 CDK1|CE 983|1063| NPF|CREB 1385|204 1|EPHB1| 7|2247|40 FGF2|SM GO 89|4208|5 GO:00486 AD4|MEF 1 -2.79026 M1 1 0 Biological 19 regulation of muscle organ development -2.79026 2.483214 3.598751 24156 156 873 14 1.603666 0.425147 600|7093| -1.20788 0 117 0 0 -3.28848 6.510612 34 2C|MAPK Processes 10324|10 11|TLL2|K 413|2341 LHL41|YA 4|57486|9 P1|ZFPM 3649 2|NLN|M CENPE|CE 1062|106 NPF|CREB 3|1385|24 1|CENPI| 91|3070|4 HELLS|M 175|5931| CM6|RBB 8208|831 P7|CHAF1 GO 8|8357|23 B|CDC45| GO:00650 1 -2.78954 M1 1 0 Biological 19 protein-DNA complex assembly -2.78954 2.137122 3.47117 24156 246 873 19 2.176403 0.493838 421|5535 H3C10|IT -1.20777 0 31 0 0 -6.31644 12.57732 04 Processes 5|55506|5 GB3BP|HJ 5839|570 URP|MAC 82|79003| ROH2A2| 91687|40 CENPN|K 1541|653 NL1|MIS1 604 2|CENPL| CENPP|H ADORA2 B|FAS|CD 136|355|1 KN2B|CO 030|1312| MT|CYP2 1591|517 4A1|PENK 9|5366|55 |PMAIP1| 63|5587|6 PRKAA2|P 422|1063 GO RKD1|SFR GO:00316 1|10991|2 1 -2.78592 M1 1 0 Biological 19 cellular response to extracellular stimulus -2.78592 2.08831 3.449447 24156 265 873 20 2.290951 0.50637 P1|POST -1.20501 0 50 0 0 -5.25088 2.470545 68 6153|817 Processes N|SLC38A 88|84687| 3|KIF26A| 93649|14 NUAK2|P 3686|154 PP1R9B| 743|4407 MYOCD|S 38|65296 ESN3|BM 8 T2|MAP1 LC3C|CAS BMP7|CD H11|CRA 655|1009| BP2|CREB 1382|138 1|DAB1|E 5|1600|20 PHB1|EP 47|2048|2 HB2|FN1| 335|2803| GOLGA4| 2902|408 GRIN1|S 9|4902|49 MAD4|NR 16|4974|5 TN|NTRK 354|6387| 3|OMG|P GO 6498|707 LP1|CXCL GO:00615 1 -2.78557 M1 1 0 Biological 19 axon development -2.78557 1.735957 3.304492 24156 526 873 33 3.780069 0.645469 4|7852|94 12|SKIL|TI -1.20501 0 29 0 0 -6.42481 3.074456 64 Processes 23|9723|2 AM1|CXC 3768|260 R4|NTN1| 37|54437| SEMA3E|F 55816|56 LRT2|SIPA 963|8457 1L1|SEMA 0|84612|9 5B|DOK5| 1624|916 RGMA|C 53|13358 OL25A1|P 4|284217| ARD6B|N 284656 EXN|BOC| EGFLAM| LAMA1|E GO 3832|475 KIF11|NE GO:00512 1 -2.77445 M1 1 0 Biological 19 centrosome separation -2.77445 7.378694 4.785099 24156 15 873 4 0.45819 0.22857 1|6790|54 K2|AURK -1.1984 0 80 0 0 -4.01173 9.223368 99 Processes 820 A|NDE1 ALDH1A3 220|2048| |EPHB2|F 2535|562 ZD2|PRO 9|6935|94 GO X1|ZEB1| GO:00424 23|10736| 1 -2.77344 M1 1 0 Biological 19 ear morphogenesis -2.77344 2.699522 3.659035 24156 123 873 12 1.37457 0.394068 NTN1|SIX -1.1984 0 7 0 0 -11.4306 6.148912 71 51141|53 Processes 2|INSIG2| 904|8018 MYO3A|C 4|116039| EP290|OS 133060 R2|OTOP XIAP|BIRC 331|332|7 5|C4A|CO 20|1294|5 L7A1|SER 270|6692| PINE2|SPI GO 7078|707 NT1|TIMP GO:00048 1 -2.24781 M1 1 0 Molecular 21 endopeptidase inhibitor activity -2.24781 2.164142 3.027097 24156 179 873 14 1.603666 0.425147 9|7980|92 3|TIMP4|T -0.83151 0 116 0 0 -3.2998 2.23146 66 Functions 32|79444| FPI2|PTT 80760|11 G1|BIRC7| 7166|124 ITIH5|WFI 857 KKN1|WFI KKN2 C4A|CHG 720|1114| B|CP|VCA 1356|146 N|FBN1|F Regulation of Insulin-like Growth Factor 2|2200|23 R-HSA- Reactome N1|LTBP1 1 -2.2445 M1 1 0 6 (IGF) transport and uptake by Insulin-like -2.2445 2.434969 3.114604 24156 125 873 11 1.260023 0.37751 35|4052|4 -0.82904 0 43 0 0 -5.54756 2.605302 381426 Gene Sets |MMP1|P Growth Factor Bi 312|5179| ENK|FAM 54757|91 20A|CHR 851 DL1 BRCA2|C 675|983|4 DK1|MC 175|4361| M6|MRE1 GO 4998|499 1|ORC1|O GO:00007 Cellular 1 -2.2445 M1 1 0 20 nuclear chromosome, telomeric region -2.2445 2.434969 3.114604 24156 125 873 11 1.260023 0.37751 9|7520|99 RC2|XRC -0.82904 0 85 0 0 -3.87201 3.458763 84 Compone 37|55506| C5|DCLRE nts 80119|80 1A|MACR 169 OH2A2|PI F1|CTC1 ADORA2 A|GABRA GO 135|2555| 2|GABRA GO:00325 Cellular 2556|255 1 -2.24088 M1 1 0 20 neuron projection membrane -2.24088 3.228179 3.346142 24156 60 873 7 0.801833 0.301847 3|GABRA -0.82724 0 112 0 0 -3.34087 10.06186 89 Compone 7|2565|28 4|GABRG nts 90|84687 1|GRIA1|P PP1R9B CHRNA1| GABRA2| 1134|255 GO GABRA3| GO:00228 5|2556|25 1 -2.24088 M1 1 0 Molecular 21 transmitter-gated ion channel activity -2.24088 3.228179 3.346142 24156 60 873 7 0.801833 0.301847 GABRA4| -0.82724 0 112 0 0 -3.34087 10.06186 24 57|2565|2 Functions GABRG1| 890|2902 GRIA1|GR IN1 CHRNA1| GABRA2| 1134|255 GO GABRA3| GO:00228 5|2556|25 1 -2.24088 M1 1 0 Molecular 21 transmitter-gated channel activity -2.24088 3.228179 3.346142 24156 60 873 7 0.801833 0.301847 GABRA4| -0.82724 0 112 0 0 -3.34087 10.06186 35 57|2565|2 Functions GABRG1| 890|2902 GRIA1|GR IN1 1266|367 CNN3|ITG GO 2|3673|29 A1|ITGA2| GO:00986 1 -2.24088 M1 1 0 Molecular 21 cell adhesion mediator activity -2.24088 3.228179 3.346142 24156 60 873 7 0.801833 0.301847 091|2976 STXBP6|T -0.82724 0 212 1 1 -2.24088 6.917526 31 Functions 6|91624|3 MOD3|N 42035 EXN|GLD ACTN2|A DORA2A| CAMK2A| CDH9|CD 88|135|81 H10|CHR 5|1007|10 M3|CHRN 08|1131|1 A1|CNN3| 134|1266| COMT|D 1312|160 AB1|EPHB 0|2048|25 2|GABRA 55|2556|2 2|GABRA 557|2565| 3|GABRA 2890|290 4|GABRG GO 2|2913|36 1|GRIA1| GO:00987 Cellular 90|3706|3 1 -2.24012 M1 1 0 20 postsynapse -2.24012 1.563773 2.792262 24156 637 873 36 4.123711 0.672965 GRIN1|GR -0.82724 0 58 0 0 -4.67369 3.739203 94 Compone 739|3759| M3|ITGB3 nts 3838|420 |ITPKA|KC 8|4916|70 NA4|KCN 74|8537|1 J2|KPNA2 0369|111 |MEF2C|N 41|11346| TRK3|TIA 22871|23 M1|BCAS 237|2603 1|CACNG 7|57537|8 2|IL1RAPL 4687|347 1|SYNPO| 730 NLGN1|A RC|SIPA1 L1|SORCS 2|PPP1R9 C4A|CHG 720|1114| B|CP|VCA 1356|146 N|FBN1|F R-HSA- Reactome 2|2200|23 1 -2.23942 M1 1 0 6 Post-translational protein phosphorylation -2.23942 2.562047 3.150341 24156 108 873 10 1.145475 0.360151 N1|LTBP1 -0.82724 0 43 0 0 -5.54756 2.605302 8957275 Gene Sets 35|4052|5 |PENK|FA 179|5475 M20A|CH 7|91851 RDL1 947|1385| CD34|CRE GO GO:00716 regulation of transforming growth factor 4052|406 B1|LTBP1| 1 -2.77297 M1 1 0 Biological 19 -2.77297 4.611684 4.19917 24156 36 873 6 0.687285 0.279617 -1.1984 0 163 1 1 -2.77297 7.905744 34 beta production 0|4089|70 LUM|SMA Processes 57 D4|THBS1 FAS|CASP 2|ITGA2|K 355|835|3 CNJ2|MA 673|3759| P3K1|MM 4214|431 P7|SERPI 6|5270|63 NE2|CXCL GO 87|7057|7 GO:00096 12|THBS1 1 -2.77009 M1 1 0 Biological 19 response to mechanical stimulus -2.77009 2.239961 3.494558 24156 210 873 17 1.947308 0.467671 132|7852| -1.19611 0 83 0 0 -3.90769 3.852799 12 |TNFRSF1 Processes 8772|106 A|CXCR4| 31|27063| FADD|PO 51284|11 STN|ANK 7531|642 RD1|TLR7 658 |TMC1|SC X BRCA2|C 675|983|4 DK1|MC 175|4361| M6|MRE1 GO 4998|499 1|ORC1|O GO:00007 Cellular 9|7520|99 RC2|XRC 1 -2.23825 M1 1 0 20 chromosome, telomeric region -2.23825 2.234232 3.04257 24156 161 873 13 1.489118 0.40992 -0.82648 0 85 0 0 -3.87201 3.458763 81 Compone 37|54780| C5|DCLRE nts 55183|55 1A|NSMC 506|8011 E4A|RIF1| 9|80169 MACROH 2A2|PIF1| EPHB1|EP 2047|204 HB2|GPC 8|2239|29 4|GRIN1|I 02|3706|4 TPKA|ME 208|4916| F2C|NTRK 7058|707 3|THBS2| GO GO:00508 4|9423|11 TIAM1|NT 1 -2.75641 M1 1 0 Biological 19 regulation of synapse organization -2.75641 2.174943 3.459246 24156 229 873 18 2.061856 0.480948 -1.18303 0 63 0 0 -4.50244 10.37629 07 141|2287 N1|IL1RA Processes 1|23237|2 PL1|NLG 3768|260 N1|ARC|F 37|26280| LRT2|SIPA 54674|34 1L1|IL1RA 7730 PL2|LRRN 3|LRRTM1 VEGFD|IT GO 2277|367 GO:00509 GA2|NTR 1 -2.7514 M1 1 0 Biological 19 positive regulation of positive chemotaxis -2.7514 5.534021 4.391946 24156 25 873 5 0.572738 0.255402 3|4916|52 -1.1792 0 137 0 0 -3.04056 10.37629 27 K3|PGF|C Processes 28|6387 XCL12 ADORA2 B|CMKLR 136|1240| 1|EDN2|E 1907|190 DN3|FGF 8|2247|22 2|VEGFD|I 77|3673|4 TGA2|ME 233|4916| T|NTRK3| 5228|558 GO PGF|PRK GO:00321 positive regulation of response to external 7|6387|70 1 -2.74719 M1 1 0 Biological 19 -2.74719 1.958192 3.367551 24156 325 873 23 2.634593 0.542066 D1|CXCL1 -1.17558 0 42 0 0 -5.75682 3.654542 03 stimulus 56|7057|7 Processes 2|THBD|T 074|7132| HBS1|TIA 7852|876 M1|TNFR 7|9180|95 SF1A|CXC 47|51284| R4|RIPK2| 196527|7 OSMR|CX 29230 CL14|TLR 7|ANO6|C 1294|149 COL7A1| 0|4017|42 CCN2|LO 08|5744|1 XL2|MEF2 GO 0736|232 C|PTHLH| GO:00020 1 -2.74341 M1 1 0 Biological 19 chondrocyte differentiation -2.74341 2.677752 3.626893 24156 124 873 12 1.37457 0.394068 13|25886| SIX2|SULF -1.17354 0 53 0 0 -4.98746 13.83505 62 Processes 91461|11 1|POC1A| 6039|359 PKDCC|O 845|6426 SR2|RFLN 58 B|SCX 186|655|2 AGTR2|B 247|3280| MP7|FGF GO GO:00720 3976|408 2|HES1|LI 1 -2.74319 M1 1 0 Biological 19 nephron morphogenesis -2.74319 3.234168 3.802184 24156 77 873 9 1.030928 0.341867 -1.17354 0 10 0 0 -10.1376 3.952872 28 9|5228|10 F|SMAD4| Processes 736|3081 PGF|SIX2| 2 SOX8 ITGB4|LA 3691|390 MA3|LAM Canonical 9|3914|42 1 -2.22335 M239 M1 1 0 11 PID A6B1 A6B4 INTEGRIN PATHWAY -2.22335 3.609144 3.429806 24156 46 873 6 0.687285 0.279617 B3|MET|R -0.81443 0 77 0 0 -4.11211 18.44674 Pathways 33|6258|2 XRG|LAM 84217 A1 6503|746 SLA|WEE1 GO GO:00047 non-membrane spanning protein tyrosine 5|8767|98 |RIPK2|M 1 -2.22335 M1 1 0 Molecular 21 -2.22335 3.609144 3.429806 24156 46 873 6 0.687285 0.279617 -0.81443 0 213 1 1 -2.22335 3.609144 15 kinase activity 33|55359| ELK|STYK Functions 91461 1|PKDCC CD34|EP 947|2048| HB2|PDG 5156|527 FRA|SERP GO GO:00301 0|6915|70 INE2|TBX 1 -2.74319 M1 1 0 Biological 19 regulation of blood coagulation -2.74319 3.234168 3.802184 24156 77 873 9 1.030928 0.341867 -1.17354 0 108 0 0 -3.3802 5.825285 93 56|7057|1 A2R|THB Processes 70692|19 D|THBS1| 6527 ADAMTS 18|ANO6 BMP7|HE 655|3280| S1|SMAD 4089|409 4|SMAD5| 0|4208|42 MEF2C|M 22|5081|5 EOX1|PA 125|5308| X7|PCSK5 5992|642 |PITX2|RF 2|6491|67 X4|SFRP1| 90|6935|6 STIL|AUR GO 939|8726| GO:00073 KA|ZEB1| 1 -2.74279 M1 1 0 Biological 19 pattern specification process -2.74279 1.799177 3.298647 24156 446 873 29 3.321879 0.606525 8854|909 -1.17354 0 26 0 0 -6.76747 2.184482 89 TCF15|EE Processes 6|9645|10 D|ALDH1 468|1073 A2|TBX18 6|23237|5 |MICAL2| 1098|545 FST|SIX2| 67|55502| ARC|IFT5 57619|16 2|DLL4|H 1582|339 ES6|SHR 829|4414 OOM3|D 78 NAAF4|C BMP7|CD 655|1021| K6|VCAN| 1462|159 CYP24A1| 1|2201|40 FBN2|SM 90|4208|5 AD5|MEF 179|5587| 2C|PENK| GO GO:00016 5744|642 PRKD1|PT 1 -2.73551 M1 1 0 Biological 19 osteoblast differentiation -2.73551 2.165486 3.438961 24156 230 873 18 2.061856 0.480948 -1.16685 0 65 0 0 -4.41834 4.966429 49 2|22800|2 HLH|SFRP Processes 6156|308 1|RRAS2| 12|11758 RSL1D1|S 1|148979| OX8|TWIS 202151|3 T2|GLIS1| 40419 RANBP3L| RSPO2 BARD1|B 580|672|4 RCA1|MR 361|5563| E11|PRKA R-HSA- Reactome Regulation of TP53 Activity through 5600|679 1 -2.21917 M1 1 0 6 -2.21917 2.706858 3.176132 24156 92 873 9 1.030928 0.341867 A2|MAPK -0.8139 0 101 0 0 -3.49696 2.706858 6804756 Gene Sets Phosphorylation 0|9156|22 11|AURK 974|8001 A|EXO1|T 0 PX2|RMI1 BMP7|E2F 655|1870| 2|NFATC1 4772|691 |TBXA2R| 5|7057|70 THBS1|TH 58|7075|9 BS2|TIE1| GO 723|1051 GO:19013 negative regulation of vasculature SEMA3E|F 1 -2.72243 M1 1 0 Biological 19 -2.72243 2.28207 3.471701 24156 194 873 16 1.832761 0.453972 6|23213|2 -1.15494 0 15 0 0 -9.08083 2.73285 43 development BLN5|SUL Processes 8984|545 F1|RGCC| 67|64102| DLL4|TN 79812|64 MD|MMR 1700|729 N2|ECSC 230 R|CCR2 BMP7|FZ 655|2535| D2|SFRP1 6422|649 |STIL|SPIN 1|6692|85 GO T1|LMO4| GO:00018 43|9585|3 1 -2.71374 M1 1 0 Biological 19 embryonic epithelial tube formation -2.71374 2.65633 3.595068 24156 125 873 12 1.37457 0.394068 KIF20B|S -1.14684 0 64 0 0 -4.46525 3.120688 38 0812|510 Processes OX8|IFT5 98|57619| 2|SHROO 131405|1 M3|TRIM 44165 71|PRICKL CENPE|KI 1062|383 F11|DYNL 2|8655|94 L1|KIF23| 93|9585|9 KIF20B|DL 787|9928| GAP5|KIF 10125|11 14|RASGR 004|2413 P1|KIF2C| GO 7|26153|5 GO:00070 KIF4A|KIF 1 -2.71292 M1 1 0 Biological 19 microtubule-based movement -2.71292 2.017612 3.364043 24156 288 873 21 2.405498 0.518571 1098|548 -1.1466 0 46 0 0 -5.44351 7.281606 18 26A|IFT52 Processes 20|55112| |NDE1|W 81930|11 DR60|KIF 7178|126 18A|SSX2I 731|1615 P|CCSAP| 82|24617 DNAAF4| 6|339829| GAS2L2|C 347240 CDC39|KI VCAN|GP 1462|223 C4|FGF2| 9|2247|31 HMMR|L 61|4060|4 UM|OGN| GO 969|7358| UGDH|HS GO:00302 1 -2.71229 M1 1 0 Biological 19 glycosaminoglycan metabolic process -2.71229 2.436361 3.518641 24156 159 873 14 1.603666 0.425147 9653|110 2ST1|KER -1.14655 0 96 0 0 -3.66151 10.37629 03 Processes 81|51363| A|CHST15 55790|80 |CSGALN 760|9301 ACT1|ITIH 0|133584 5|B3GNT7 |EGFLAM 186|2247| AGTR2|F 3280|397 GF2|HES1 GO GO:00720 6|4089|42 |LIF|SMA 1 -2.711 M1 1 0 Biological 19 nephron tubule development -2.711 2.97528 3.695612 24156 93 873 10 1.145475 0.360151 -1.14643 0 10 0 0 -10.1376 3.952872 80 08|5228|1 D4|MEF2 Processes 0413|107 C|PGF|YA 36|30812 P1|SIX2|S CDO1|CR 1036|138 EB1|CCN 5|1490|29 2|GRIN1|I 02|3673|4 TGA2|NT 916|5156| RK3|PDGF 5563|625 RA|PRKA 8|6422|69 A2|RXRG| 35|7054|7 SFRP1|ZE GO GO:00011 075|7520| B1|TH|TIE 1 -2.70943 M1 1 0 Biological 19 response to acid chemical -2.70943 1.913782 3.319924 24156 347 873 24 2.749141 0.553399 -1.14601 0 165 1 1 -2.70943 2.669922 01 8854|104 1|XRCC5| Processes 13|10891| ALDH1A2 51141|54 |YAP1|PP 997|5603 ARGC1A|I 4|84687|1 NSIG2|TE 43686|33 SC|PDGF 9479|652 C|PPP1R9 968 B|SESN3| BRINP3|C COL5A1| 1289|129 COL7A1| 4|1295|23 GO COL8A1|F GO:00074 35|3624|3 1 -2.7038 M1 1 0 Biological 19 endoderm development -2.7038 3.192704 3.755851 24156 78 873 9 1.030928 0.341867 N1|INHB -1.14155 0 77 0 0 -4.11211 18.44674 92 909|3914| Processes A|LAMA3| 4089|232 LAMB3|S 37 MAD4|AR GO 672|5519 BRCA1|RE GO:00009 Cellular 1 -2.20732 M1 1 0 20 gamma-tubulin complex -2.20732 5.270496 3.791015 24156 21 873 4 0.45819 0.22857 6|55835|8 SF1|CENP -0.8139 0 215 1 1 -2.20732 5.270496 30 Compone 0184 J|CEP290 nts CD34|EP 947|2048| HB2|PDG 5156|527 FRA|SERP GO GO:19000 0|6915|70 INE2|TBX 1 -2.7038 M1 1 0 Biological 19 regulation of hemostasis -2.7038 3.192704 3.755851 24156 78 873 9 1.030928 0.341867 -1.14155 0 108 0 0 -3.3802 5.825285 46 56|7057|1 A2R|THB Processes 70692|19 D|THBS1| 6527 ADAMTS 18|ANO6 ADORA2 A|BMP7|L DLRAD4| 135|655|7 CDKN2B| 53|1030|1 DUSP7|EP 849|2048| HB2|MEC 2122|362 OM|INHB 4|3958|39 A|LGALS3 76|4089|4 |LIF|SMA 916|5167| D4|NTRK 5783|579 3|ENPP1| 5|6422|64 PTPN13|P 56|7078|8 TPRJ|SFR GO 655|9104| P1|SH3GL GO:00459 negative regulation of phosphate metabolic 1 -2.69166 M1 1 0 Biological 19 -2.69166 1.668549 3.202824 24156 597 873 36 4.123711 0.672965 9814|108 2|TIMP3| -1.13098 0 167 1 1 -2.69166 1.668549 36 process Processes 91|11072| DYNLL1|R 22843|23 GN|SFI1|P 504|5499 PARGC1A 7|55125|5 |DUSP14| 6937|570 PPM1E|RI 82|57718| MBP2|TES 84687|84 C|CEP192 930|9364 |PMEPA1| 9|116496| KNL1|PPP 392617|1 4R4|PPP1 00506658 R9B|MAS TL|MYOC D|NIBAN 1|ELFN1| ADORA2 A|XIAP|BI RC5|FAS| 135|331|3 C4A|COL 32|355|72 7A1|CCN 0|1294|14 2|GRIN1| 90|2902|4 MBP|SER 155|5270| PINE2|PM 5366|669 AIP1|SPIN 2|7057|70 T1|THBS1 GO 78|7079|7 GO:00525 |TIMP3|TI 1 -2.69151 M1 1 0 Biological 19 regulation of endopeptidase activity -2.69151 1.805974 3.261516 24156 429 873 28 3.207331 0.596329 980|8743| -1.13098 0 116 0 0 -3.2998 2.23146 48 MP4|TFPI Processes 8767|877 2|TNFSF1 2|9232|98 0|RIPK2|F 12|9966|2 ADD|PTT 3151|550 G1|DELE1 31|79444| |TNFSF15| 80760|11 GRAMD4| 7166|124 USP47|BI 857 RC7|ITIH5 |WFIKKN1 |WFIKKN2 BMP7|CD 655|983|1 K1|SLC31 317|1545| A1|CYP1B 1894|288 1|ECT2|G 2|3039|42 PX7|HBA1 33|5742|7 |MET|PTG GO GO:00972 054|7296| S1|TH|TX 1 -2.68981 M1 1 0 Biological 19 cellular response to toxic substance -2.68981 2.09455 3.375352 24156 251 873 19 2.176403 0.493838 -1.12987 0 120 0 0 -3.26614 6.385408 37 9104|102 NRD1|RG Processes 76|10516| N|NET1|F 10587|10 BLN5|TX 891|5446 NRD2|PP 4|137902| ARGC1A| 140809 XRN1|PX DNL|SRX ACTN1|A DORA2A| 87|135|94 CD34|EN 7|954|128 TPD2|CO 9|1816|20 L5A1|DR 48|2157|2 D5|EPHB2 247|2335| |F8|FGF2| 2814|367 FN1|GP5|I 3|3690|50 TGA2|ITG 81|5156|5 B3|PAX7| 175|5270| PDGFRA| 6915|705 PECAM1| GO 6|7057|78 GO:00420 SERPINE2 1 -2.68695 M1 1 0 Biological 19 wound healing -2.68695 1.681343 3.204766 24156 576 873 35 4.009164 0.663949 52|7980|8 -1.12802 0 108 0 0 -3.3802 5.825285 60 |TBXA2R| Processes 357|1041 THBD|TH 3|10631|2 BS1|CXCR 3414|508 4|TFPI2|H 08|94121| 3C10|YAP 113146|1 1|POSTN| 39189|17 ZFPM2|A 0692|196 K3|SYTL4| 527|2197 AHNAK2| 70|65360 DGKK|AD 4|100506 AMTS18| 658 ANO6|GJ D4|H3C1 CDH5|CD 1003|100 R-HSA- Reactome H7|CDH9| 1 -2.20472 M1 1 0 6 Adherens junctions interactions -2.20472 4.19244 3.553491 24156 33 873 5 0.572738 0.255402 5|1007|10 -0.8139 0 32 0 0 -6.28754 6.917526 418990 Gene Sets CDH10|C 08|1009 DH11 2048|233 EPHB2|FN Canonical 5|3673|39 1|ITGA2|L 1 -2.20472 M240 M1 1 0 11 PID SYNDECAN 2 PATHWAY -2.20472 4.19244 3.553491 24156 33 873 5 0.572738 0.255402 -0.8139 0 77 0 0 -4.11211 18.44674 Pathways 09|28421 AMA3|LA 7 MA1 BMP7|FB 655|2201| N2|GPM6 2824|420 B|MEF2C| 8|5167|57 ENPP1|PT 44|54757| GO HLH|FAM GO:00312 56172|91 1 -2.68682 M1 1 0 Biological 19 biomineral tissue development -2.68682 2.421134 3.492342 24156 160 873 14 1.603666 0.425147 20A|ANK -1.12802 0 65 0 0 -4.41834 4.966429 14 461|1160 Processes H|PKDCC| 39|13306 OSR2|OT 0|196527| OP1|ANO 340419|3 6|RSPO2| 59845 RFLNB 2247|369 FGF2|ITG GO GO:00199 0|7852|51 B3|CXCR4 1 -2.20472 M1 1 0 Molecular 21 chemokine binding -2.20472 4.19244 3.553491 24156 33 873 5 0.572738 0.255402 -0.8139 0 93 0 0 -3.70842 5.321174 56 554|7292 |ACKR4|C Functions 30 CR2 ADORA2 A|ADORA 2B|CALB2 135|136|7 |CAMK2A 94|815|10 |CDH11|C 09|1385|1 REB1|CRH 395|1816| R2|DRD5| 2047|204 EPHB1|EP 8|2890|29 HB2|GRIA 02|2913|3 1|GRIN1| 269|3706| GO GRM3|HR GO:00508 modulation of chemical synaptic 4208|488 1 -2.68565 M1 1 0 Biological 19 -2.68565 1.783184 3.247374 24156 450 873 29 3.321879 0.606525 H1|ITPKA| -1.12743 0 49 0 0 -5.27843 3.609144 04 transmission 5|5270|10 Processes MEF2C|N 590|1134 PTX2|SER 6|22871|2 PINE2|SC 3237|260 GN|SYNP 37|55784| O|NLGN1 57537|57 |ARC|SIPA 616|8468 1L1|MCT 7|347730| P2|SORCS 729230 2|TSHZ3| PPP1R9B| LRRTM1| 835|983|1 CASP2|C 021|1030| DK1|CDK 2273|679 6|CDKN2 GO GO:20001 negative regulation of G1/S transition of 0|7029|74 B|FHL1|A 1 -2.68444 M1 1 0 Biological 19 -2.68444 2.635248 3.563553 24156 126 873 12 1.37457 0.394068 -1.12679 0 30 0 0 -6.32789 4.035223 34 mitotic cell cycle 65|28984| URKA|TF Processes 51512|57 DP2|WEE 165|1444 1|RGCC|G 55 TSE1|GJC PRDM1|D 639|1600| AB1|HES1 3280|512 |PCSK5|P 5|5156|64 DGFRA|SF GO 22|6425|8 GO:00551 RP1|SFRP 1 -2.68015 M1 1 0 Biological 19 digestive system development -2.68015 2.515464 3.519505 24156 143 873 13 1.489118 0.40992 854|1073 -1.12421 0 139 0 0 -2.9963 4.069133 23 5|ALDH1 Processes 6|56034|9 A2|SIX2|P 1461|936 DGFC|PK 49|33982 DCC|MY 9 OCD|CCD ADORA2 A|BMP7|L DLRAD4| 135|655|7 CDKN2B| 53|1030|1 DUSP7|EP 849|2048| HB2|MEC 2122|362 OM|INHB 4|3958|39 A|LGALS3 76|4089|4 |LIF|SMA 916|5167| D4|NTRK 5783|579 3|ENPP1| 5|6422|64 PTPN13|P 56|7078|8 TPRJ|SFR GO 655|9104| P1|SH3GL GO:00105 negative regulation of phosphorus 1 -2.67952 M1 1 0 Biological 19 -2.67952 1.665759 3.192195 24156 598 873 36 4.123711 0.672965 9814|108 2|TIMP3| -1.12416 0 167 0 0 -2.69166 1.668549 63 metabolic process Processes 91|11072| DYNLL1|R 22843|23 GN|SFI1|P 504|5499 PARGC1A 7|55125|5 |DUSP14| 6937|570 PPM1E|RI 82|57718| MBP2|TES 84687|84 C|CEP192 930|9364 |PMEPA1| 9|116496| KNL1|PPP 392617|1 4R4|PPP1 00506658 R9B|MAS TL|MYOC D|NIBAN 1|ELFN1| 655|2201| BMP7|FB 2824|420 N2|GPM6 GO 8|5167|56 B|MEF2C| GO:00701 regulation of biomineral tissue 1 -2.67613 M1 1 0 Biological 19 -2.67613 2.943628 3.655968 24156 94 873 10 1.145475 0.360151 172|9146 ENPP1|A -1.12133 0 65 0 0 -4.41834 4.966429 67 development Processes 1|116039| NKH|PKD 196527|3 CC|OSR2| 59845 ANO6|RF BRCA1|C 672|947|1 D34|CDH 003|1545| 5|CYP1B1 2247|227 |FGF2|VE 7|5228|55 GFD|PGF| GO 87|6915|7 PRKD1|TB GO:19040 positive regulation of vasculature 1 -2.67375 M1 1 0 Biological 19 -2.67375 2.137605 3.378723 24156 233 873 18 2.061856 0.480948 057|7075| XA2R|TH -1.11956 0 15 0 0 -9.08083 2.73285 18 development Processes 7852|102 BS1|TIE1| 66|51129| CXCR4|R 57381|57 AMP2|AN 608|9364 GPTL4|RH 9|147372 OJ|JCAD| MYOCD| 186|1046 AGTR2|FS GO GO:00480 8|27123|1 T|DKK2|W 1 -2.20472 M1 1 0 Molecular 21 receptor antagonist activity -2.20472 4.19244 3.553491 24156 33 873 5 0.572738 0.255402 -0.8139 0 205 0 0 -2.28131 4.19244 19 17166|12 FIKKN1|W Functions 4857 FIKKN2 VEGFD|IT GO 2277|367 GO:00509 GA2|NTR 1 -2.67161 M1 1 0 Biological 19 regulation of positive chemotaxis -2.67161 5.321174 4.268752 24156 26 873 5 0.572738 0.255402 3|4916|52 -1.11956 0 137 0 0 -3.04056 10.37629 26 K3|PGF|C Processes 28|6387 XCL12 ADORA2 A|ADORA 2B|CALB2 135|136|7 |CAMK2A 94|815|10 |CDH11|C 09|1385|1 REB1|CRH 395|1816| R2|DRD5| 2047|204 EPHB1|EP 8|2890|29 HB2|GRIA 02|2913|3 1|GRIN1| 269|3706| GO GRM3|HR GO:00991 4208|488 1 -2.67153 M1 1 0 Biological 19 regulation of trans-synaptic signaling -2.67153 1.779231 3.234636 24156 451 873 29 3.321879 0.606525 H1|ITPKA| -1.11956 0 49 0 0 -5.27843 3.609144 77 5|5270|10 Processes MEF2C|N 590|1134 PTX2|SER 6|22871|2 PINE2|SC 3237|260 GN|SYNP 37|55784| O|NLGN1 57537|57 |ARC|SIPA 616|8468 1L1|MCT 7|347730| P2|SORCS 729230 2|TSHZ3| PPP1R9B| LRRTM1| ACTN1|C DH9|CHR NA1|COL 87|1007|1 4A5|EPHB 134|1287| 1|EPHB2| 2047|204 GPC4|GA 8|2239|25 BRA2|GRI 55|2902|3 N1|ITPKA| 706|4208| MEF2C|N 4916|705 TRK3|THB 8|7074|94 GO S2|TIAM1 GO:00508 23|9723|1 1 -2.66255 M1 1 0 Biological 19 synapse organization -2.66255 1.797594 3.235254 24156 431 873 28 3.207331 0.596329 |NTN1|SE -1.11455 0 63 0 0 -4.50244 10.37629 08 0369|111 Processes MA3E|CA 41|11346| CNG2|IL1 22871|23 RAPL1|SY 024|2323 NPO|NLG 7|23768|2 N1|PDZR 6037|262 N3|ARC|F 80|54674| LRT2|SIPA 347730|3 1L1|IL1RA 92617 PL2|LRRN 3|LRRTM1 |ELFN1 GO 1062|106 CENPE|CE GO:00513 1 -2.66202 M1 1 0 Biological 19 kinetochore assembly -2.66202 6.917526 4.584824 24156 16 873 4 0.45819 0.22857 3|55839|7 NPF|CEN -1.11455 0 2 0 0 -22.074 10.54099 82 Processes 9003 PN|MIS12 CORUM:2 2187|218 FANCB|F 1 -2.20452 M1 1 0 CORUM 33 FA complex (Fanconi anemia complex) -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 -0.8139 0 44 0 0 -5.52611 9.223368 739 8|80010 ANCF|RM GO 2048|103 EPHB2|C GO:19004 positive regulation of glutamate receptor 1 -2.66202 M1 1 0 Biological 19 -2.66202 6.917526 4.584824 24156 16 873 4 0.45819 0.22857 69|23237| ACNG2|A -1.11455 0 45 0 0 -5.5147 9.223368 51 signaling pathway Processes 729230 RC|CCR2 GO GO:00474 nucleoside-triphosphate diphosphatase 1854|516 DUT|ENP 1 -2.20452 M1 1 0 Molecular 21 -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 -0.8139 0 73 0 0 -4.32747 27.6701 29 activity 7|5169 P1|ENPP3 Functions GO LAMA3|L GO:00432 Cellular 3909|391 1 -2.20452 M1 1 0 20 laminin complex -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 AMB3|LA -0.8139 0 77 0 0 -4.11211 18.44674 56 Compone 4|284217 MA1 nts R-HSA- Reactome CDC6 association with the ORC:origin 1870|499 E2F2|ORC 1 -2.20452 M1 1 0 6 -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 -0.8139 0 138 0 0 -3.01725 11.06804 68689 Gene Sets complex 8|4999 1|ORC2

R-HSA- Reactome 355|8743| FAS|TNFS 1 -2.20452 M1 1 0 6 Regulation by c-FLIP -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 -0.8139 0 141 0 0 -2.97821 18.44674 3371378 Gene Sets 8772 F10|FADD

R-HSA- Reactome 355|8743| FAS|TNFS 1 -2.20452 M1 1 0 6 Dimerization of procaspase-8 -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 -0.8139 0 141 0 0 -2.97821 18.44674 69416 Gene Sets 8772 F10|FADD BMP7|SM Canonical 655|4089| 1 -2.20452 M203 M1 1 0 11 PID ALK2 PATHWAY -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 AD4|SMA -0.8139 0 153 0 0 -2.8845 27.6701 Pathways 4090 D5 BIRC5|KIF 332|3832| 11|NEK2| 4751|679 AURKA|KI 0|9493|22 GO F23|TPX2| GO:00512 974|2413 1 -2.65549 M1 1 0 Biological 19 spindle assembly -2.65549 2.614498 3.532341 24156 127 873 12 1.37457 0.394068 KIF4A|CE -1.10857 0 8 0 0 -11.3911 5.158833 25 7|55125|7 Processes P192|HA 9441|810 US3|TUBB 27|12673 1|CCSAP| 1|259266 ASPM 88|1908|2 ACTN2|E 048|3759| DN3|EPH 5174|910 B2|KCNJ2 GO 4|10369|2 |PDZK1|R GO:19040 positive regulation of cation 1 -2.65329 M1 1 0 Biological 19 -2.65329 2.497995 3.491152 24156 144 873 13 1.489118 0.40992 3237|549 GN|CACN -1.10694 0 45 0 0 -5.5147 9.223368 64 transmembrane transport Processes 97|57165| G2|ARC|T 126755|1 ESC|GJC2| 96527|72 LRRC38|A 9230 NO6|CCR 947|1385| CD34|CRE GO GO:00716 4052|406 B1|LTBP1| 1 -2.64807 M1 1 0 Biological 19 transforming growth factor beta production -2.64807 4.368964 4.02447 24156 38 873 6 0.687285 0.279617 -1.10264 0 163 0 0 -2.77297 7.905744 04 0|4089|70 LUM|SMA Processes 57 D4|THBS1 PRDM1|L 639|4052| TBP1|PCS GO 5125|104 GO:00609 K5|TAB1| 1 -2.64283 M1 1 0 Biological 19 coronary vasculature development -2.64283 3.797857 3.873007 24156 51 873 7 0.801833 0.301847 54|11174| -1.10264 0 154 0 0 -2.86448 3.797857 76 ADAMTS Processes 93649|14 6|MYOCD 4165 |PRICKLE1 1289|154 COL5A1| GO 5|1805|40 CYP1B1|D GO:00301 1 -2.64283 M1 1 0 Biological 19 collagen fibril organization -2.64283 3.797857 3.873007 24156 51 873 7 0.801833 0.301847 17|4060|9 PT|LOXL2 -1.10264 0 174 1 1 -2.64283 3.797857 99 Processes 508|6426 |LUM|AD 58 AMTS3|S GO GO:00081 2512|624 FTL|RRM2 1 -2.20452 M1 1 0 Molecular 21 ferric iron binding -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 -0.8139 0 219 1 1 -2.20452 7.905744 99 1|7054 |TH Functions 186|2247| AGTR2|F 3280|397 GF2|HES1 GO GO:00613 6|4089|42 |LIF|SMA 1 -2.64179 M1 1 0 Biological 19 renal tubule development -2.64179 2.912642 3.616845 24156 95 873 10 1.145475 0.360151 -1.10264 0 10 0 0 -10.1376 3.952872 26 08|5228|1 D4|MEF2 Processes 0413|107 C|PGF|YA 36|30812 P1|SIX2|S GO GO:00716 2200|220 FBN1|FBN 1 -2.63853 M1 1 0 Biological 19 protein localization to extracellular region -2.63853 10.37629 5.136018 24156 8 873 3 0.343643 0.198061 -1.10264 0 24 0 0 -7.35548 20.75258 92 1|4052 2|LTBP1 Processes GO BUB1|BU GO:00451 699|701|1 1 -2.63853 M1 1 0 Biological 19 meiotic sister chromatid segregation -2.63853 10.37629 5.136018 24156 8 873 3 0.343643 0.198061 B1B|HOR -1.10264 0 25 0 0 -7.23866 13.83505 44 50280 Processes MAD2 GO BUB1|BU GO:00511 699|701|1 1 -2.63853 M1 1 0 Biological 19 meiotic sister chromatid cohesion -2.63853 10.37629 5.136018 24156 8 873 3 0.343643 0.198061 B1B|HOR -1.10264 0 25 0 0 -7.23866 13.83505 77 50280 Processes MAD2 CALB2|C 794|1131| HRM3|CR 1393|139 GO HBP|CRH 5|2902|36 GO:00436 Cellular R2|GRIN1 1 -2.19346 M1 1 0 20 axon terminus -2.19346 2.396623 3.055656 24156 127 873 11 1.260023 0.37751 73|5179|7 -0.80492 0 86 0 0 -3.83907 2.396623 79 Compone |ITGA2|PE 054|8492| nts NK|TH|PR 10590|22 SS12|SCG 2256 N|CDHR3 GO EPHB2|IL GO:00995 trans-synaptic signaling by trans-synaptic 2048|111 1 -2.63853 M1 1 0 Biological 19 -2.63853 10.37629 5.136018 24156 8 873 3 0.343643 0.198061 1RAPL1|N -1.10264 0 63 0 0 -4.50244 10.37629 45 complex 41|22871 Processes LGN1 GO ALDH1A3 GO:00021 220|8854| 1 -2.63853 M1 1 0 Biological 19 retinoic acid biosynthetic process -2.63853 10.37629 5.136018 24156 8 873 3 0.343643 0.198061 |ALDH1A -1.10264 0 131 0 0 -3.08989 10.37629 38 157506 Processes 2|RDH10 ALK|CAM 238|815|2 K2A|EPHB 047|2324| 1|FLT4|M 4361|475 RE11|NEK 1|5156|51 2|PDGFR GO 67|5587|5 A|ENPP1| GO:00467 1 -2.63334 M1 1 0 Biological 19 protein autophosphorylation -2.63334 2.119412 3.339069 24156 235 873 18 2.061856 0.480948 593|6503| PRKD1|PR -1.09894 0 16 0 0 -8.49261 2.419993 77 Processes 6790|727 KG2|SLA| 2|9833|23 AURKA|T 178|5390 TK|MELK| 4|56034|1 PASK|MY 52110 O3A|PDG FC|NEK10 BMP7|CD 655|1003| H5|CREB1 1385|149 |CCN2|EP 0|2047|20 HB1|EPH 48|3958|4 B2|LGALS 233|4312| 3|MET|M 4916|562 MP1|NTR 9|5795|64 K3|PROX1 22|7058|7 |PTPRJ|SF 456|9662| RP1|THBS 10733|10 2|WIPF1| GO 788|1114 CEP135|P GO:00440 positive regulation of cellular component 1 -2.6332 M1 1 0 Biological 19 -2.6332 1.682976 3.163545 24156 559 873 34 3.894616 0.654786 1|11346|2 LK4|IQGA -1.09894 0 14 0 0 -9.68163 3.166231 89 biogenesis Processes 2843|228 P2|IL1RA 71|22998| PL1|SYNP 23379|23 O|PPM1E| 433|2376 NLGN1|LI 8|28984|5 MCH1|IC 4443|546 E1|RHOQ| 74|55835| FLRT2|RG 85459|90 CC|ANLN| 427|3477 LRRN3|CE 30|10050 NPJ|CEP2 6658 95|BMF|L RRTM1|O ADORA2 A|CALB2| 135|794|1 CHRM3|C 131|1393| RHBP|CR 1395|289 HR2|GRIA 0|2902|36 1|GRIN1|I 73|4155|5 TGA2|MB 179|6790| P|PENK|A GO 7054|707 URKA|TH| GO:00332 Cellular 4|7133|84 1 -2.18701 M1 1 0 20 axon part -2.18701 1.716508 2.8087 24156 403 873 25 2.863688 0.564477 TIAM1|TN -0.80027 0 86 0 0 -3.83907 2.396623 67 Compone 92|9585|1 FRSF1B|P nts 0590|229 RSS12|KIF 74|24137| 20B|SCG 57165|57 N|TPX2|KI 616|8468 F4A|GJC2| 7|91653|2 TSHZ3|PP 22256|34 P1R9B|BO 7730 C|CDHR3| LRRTM1 655|1382| BMP7|CR 2201|369 ABP2|FBN 1|4089|51 2|ITGB4|S 25|5308|8 MAD4|PC GO 854|5109 SK5|PITX2 GO:00487 1 -2.63058 M1 1 0 Biological 19 appendage development -2.63058 2.305842 3.405098 24156 180 873 15 1.718213 0.439813 8|91461|1 |ALDH1A -1.0974 0 176 0 0 -2.63058 4.19244 36 Processes 16039|15 2|IFT52|P 7506|340 KDCC|OS 419|3416 R2|RDH1 40|64265 0|RSPO2| 8 FREM2|S ADORA2 A|ADORA 135|136|2 2B|SLC25 91|815|11 A4|CAMK 31|1816|2 2A|CHRM KEGG 902|3269| 3|DRD5|G 1 -2.18557 hsa04020 M1 1 0 24 Calcium signaling pathway -2.18557 2.128469 2.95901 24156 182 873 14 1.603666 0.425147 -0.7996 0 115 0 0 -3.30059 4.19244 Pathway 3357|370 RIN1|HRH 6|5156|68 1|HTR2B|I 69|6915|9 TPKA|PD 1860 GFRA|TA CR1|TBXA 2R|CALM 655|1382| BMP7|CR 2201|369 ABP2|FBN 1|4089|51 2|ITGB4|S 25|5308|8 MAD4|PC GO 854|5109 SK5|PITX2 GO:00601 1 -2.63058 M1 1 0 Biological 19 limb development -2.63058 2.305842 3.405098 24156 180 873 15 1.718213 0.439813 8|91461|1 |ALDH1A -1.0974 0 176 1 1 -2.63058 4.19244 73 Processes 16039|15 2|IFT52|P 7506|340 KDCC|OS 419|3416 R2|RDH1 40|64265 0|RSPO2| 8 FREM2|S 655|4208| BMP7|ME 5081|512 F2C|PAX7 5|5156|69 |PCSK5|P GO GO:00487 35|10736| DGFRA|Z 1 -2.62689 M1 1 0 Biological 19 embryonic skeletal system development -2.62689 2.594072 3.501429 24156 128 873 12 1.37457 0.394068 -1.09479 0 11 0 0 -10.1305 3.03234 06 23213|55 EB1|SIX2| Processes 112|1160 SULF1|W 39|15750 DR60|OS 6|642658 R2|RDH1 PRDM1|F 639|2247| GF2|GAS1 2619|328 |HES1|SM 0|4089|40 AD4|SMA 90|4208|4 D5|MEF2 916|5081| C|NTRK3| GO 5629|609 GO:00451 PAX7|PR 1 -2.61606 M1 1 0 Biological 19 cell fate commitment -2.61606 2.019716 3.287079 24156 274 873 20 2.290951 0.50637 5|6422|85 -1.0845 0 177 1 1 -2.61606 2.019716 65 OX1|ROR Processes 43|9096|1 A|SFRP1|L 0736|308 MO4|TBX 12|54567| 18|SIX2|S 64641|80 OX8|DLL4 326|1489 |EBF2|WN 79 T10A|GLI FGF2|VEG 2247|227 FD|FLT4| 7|2324|33 HTR2B|IT GO 57|3690|5 GO:00019 positive regulation of endothelial cell GB3|PGF| 1 -2.61034 M1 1 0 Biological 19 -2.61034 2.717599 3.52792 24156 112 873 11 1.260023 0.37751 228|5587| -1.07986 0 68 0 0 -4.38679 2.76701 38 proliferation PRKD1|PR Processes 5629|638 OX1|CXC 7|57608|4 L12|JCAD| 41478 NRARP ADORA2 136|1131| B|CHRM3 1907|190 |EDN2|ED GO 8|3357|36 N3|HTR2 GO:00069 1 -2.61034 M1 1 0 Biological 19 smooth muscle contraction -2.61034 2.717599 3.52792 24156 112 873 11 1.260023 0.37751 73|6869|6 B|ITGA2|T -1.07986 0 115 0 0 -3.30059 4.19244 39 Processes 915|9312| ACR1|TBX 23213|93 A2R|KCN 649 B2|SULF1| MYOCD GABRA2| 2555|255 GO GABRA3| GO:00072 gamma-aminobutyric acid signaling 6|2557|25 1 -2.59562 M1 1 0 Biological 19 -2.59562 5.124093 4.151756 24156 27 873 5 0.572738 0.255402 GABRA4| -1.06989 0 112 0 0 -3.34087 10.06186 14 pathway 65|16582 Processes GABRG1| 9 GPR156 BMP7|CD GO 655|947|3 GO:00720 34|HES1| 1 -2.59562 M1 1 0 Biological 19 glomerulus vasculature development -2.59562 5.124093 4.151756 24156 27 873 5 0.572738 0.255402 280|5156| -1.06989 0 119 0 0 -3.27941 18.44674 12 PDGFRA| Processes 5175 PECAM1 ACTC1|S 70|4089|5 MAD4|PR GO 629|7135| OX1|TNN GO:00550 1 -2.59556 M1 1 0 Biological 19 cardiac muscle tissue morphogenesis -2.59556 3.353952 3.708022 24156 66 873 8 0.91638 0.322501 7139|234 I1|TNNT2| -1.06989 0 75 0 0 -4.23321 3.816566 08 Processes 14|27063| ZFPM2|A 54567 NKRD1|D LL4 4208|515 MEF2C|P 6|10736|5 DGFRA|SI GO GO:19048 1141|517 X2|INSIG2 1 -2.59556 M1 1 0 Biological 19 cranial skeletal system development -2.59556 3.353952 3.708022 24156 66 873 8 0.91638 0.322501 -1.06989 0 179 1 1 -2.59556 4.882959 88 15|55165| |RAB23|C Processes 157506|1 EP55|RDH 58326 10|FREM1 BMP7|FZ 655|2535| D2|HES1| 3280|408 GO SMAD4| GO:00031 9|4208|48 1 -2.58982 M1 1 0 Biological 19 outflow tract morphogenesis -2.58982 3.074456 3.621219 24156 81 873 9 1.030928 0.341867 MEF2C|N -1.06574 0 75 0 0 -4.23321 3.816566 51 86|5308|9 Processes PY1R|PIT 249|2341 X2|DHRS 4 3|ZFPM2 COL4A5| COL5A1| 1287|128 COL9A3| 9|1299|13 CREB1|D 85|1600|2 AB1|EPHB 047|2048| 1|EPHB2| 2902|367 GRIN1|IT 2|3673|36 GA1|ITGA 90|4155|4 2|ITGB3| 233|4902| MBP|MET 5600|632 |NRTN|M 8|6387|64 APK11|SC R-HSA- Reactome 1 -2.17277 M1 1 0 6 Nervous system development -2.17277 1.582519 2.742372 24156 577 873 33 3.780069 0.645469 56|7074|7 N3A|CXC -0.79103 0 223 1 1 -2.17277 2.325219 9675108 Gene Sets 223|7852| L12|SH3G 9423|972 L2|TIAM1| 3|10413|2 TRPC4|CX 4137|558 CR4|NTN 16|56963| 1|SEMA3 64283|79 E|YAP1|KI 861|8102 F4A|DOK 7|131873| 5|RGMA| 284217|2 ARHGEF2 84656 8|TUBAL3 |TUBB1|C OL6A6|LA ACTC1|A CTN2|AG 70|88|186 TR2|CDK1 |983|4089 |SMAD4| |4208|515 MEF2C|P 6|5629|71 DGFRA|P 39|7140|1 ROX1|TN GO 0324|105 NT2|TNN GO:00511 1 -2.58806 M1 1 0 Biological 19 striated muscle cell differentiation -2.58806 1.969736 3.244976 24156 295 873 21 2.405498 0.518571 29|27063| T3|KLHL4 -1.06503 0 13 0 0 -9.83559 6.28866 46 Processes 29766|57 1|NEBL|A 486|5753 NKRD1|T 8|58494|6 MOD3|NL 4091|936 N|ALPK3|J 49|11716 AM2|POP 6|124857 DC2|MYO CD|WFIKK N1|WFIKK ADORA2 A|AGTR2| 135|186|3 XIAP|CAL 31|794|10 B2|CDH5| 03|1240|1 CMKLR1| 312|1317| COMT|SL 1356|181 C31A1|CP 6|1907|19 |DRD5|ED 08|2247|2 N2|EDN3| 512|2840| FGF2|FTL| 2846|289 GPR17|LP 0|2902|32 AR4|GRIA 63|3357|3 1|GRIN1| 759|4089| GO HPX|HTR GO:00987 5156|516 1 -2.58711 M1 1 0 Biological 19 inorganic ion homeostasis -2.58711 1.567608 3.076667 24156 759 873 43 4.925544 0.732406 2B|KCNJ2 -1.06462 0 94 0 0 -3.67332 2.548562 71 7|6341|63 Processes |SMAD4|P 87|6869|6 DGFRA|E 915|7223| NPP1|SC 7852|910 O1|CXCL 4|9497|10 12|TACR1 590|1134 |TBXA2R| 6|22821|3 TRPC4|CX 0001|515 CR4|RGN| 54|54757| SLC4A7|S 55013|64 CGN|SYN 072|8395 PO|RASA 9|261729| 3|ERO1A| 729230 ACKR4|FA M20A|MC ECT2|EPH B2|GPR17 1894|204 |LPAR4|M 8|2840|28 ET|TIAM1 46|4233|7 |ARHGAP 074|9824| 11A|KIF14 9928|993 |ARHGAP 8|10125|1 25|RASGR GO 0276|228 P1|NET1| GO:00510 regulation of small GTPase mediated signal 1 -2.56566 M1 1 0 Biological 19 -2.56566 1.9264 3.209815 24156 316 873 22 2.520046 0.530463 21|23433| RASA3|R -1.04475 0 145 0 0 -2.94443 4.19244 56 transduction Processes 26037|26 HOQ|SIP 084|5065 A1L1|ARH 0|55789|5 GEF26|AR 7381|575 HGEF3|D 68|84952| EPDC1B|R 117178|1 HOJ|SIPA 57285 1L2|CGNL 1|SSX2IP| PRAG1 ACTN2|A 88|135|81 DORA2A| 5|1908|20 CAMK2A| 48|2273|2 EDN3|EP 902|3759| HB2|FHL1 3958|517 |GRIN1|K GO 4|6387|91 CNJ2|LGA GO:00432 1 -2.56168 M1 1 0 Biological 19 positive regulation of ion transport -2.56168 1.997841 3.234331 24156 277 873 20 2.290951 0.50637 04|10369| LS3|PDZK -1.04129 0 45 0 0 -5.5147 9.223368 70 Processes 10991|23 1|CXCL12 237|5499 |RGN|CA 7|57165|1 CNG2|SL 26755|19 C38A3|AR 6527|729 C|TESC|GJ 230 C2|LRRC3 8|ANO6|C CENPE|G 1062|280 OLGA4|KI 3|3832|53 F11|PLA2 21|8655|9 G4A|DYN 493|9585| LL1|KIF23| R-HSA- Reactome Intra-Golgi and retrograde Golgi-to-ER 9648|971 KIF20B|G 1 -2.16505 M1 1 0 6 -2.16505 2.054711 2.914816 24156 202 873 15 1.718213 0.439813 -0.78549 0 46 0 0 -5.44351 7.281606 6811442 Gene Sets traffic 2|11004|2 CC2|USP6 4137|261 NL|KIF2C| 53|79861| KIF4A|KIF 81027|81 26A|TUBA 930 L3|TUBB1| KIF18A GO 983|4208| CDK1|ME GO:00550 ventricular cardiac muscle cell 1 -2.55801 M1 1 0 Biological 19 -2.55801 6.510612 4.401046 24156 17 873 4 0.45819 0.22857 5629|936 F2C|PRO -1.03919 0 117 0 0 -3.28848 6.510612 12 differentiation Processes 49 X1|MYOC MAD2L1B GO 9587|289 GO:00070 P|RGCC|A 1 -2.55801 M1 1 0 Biological 19 regulation of exit from mitosis -2.55801 6.510612 4.401046 24156 17 873 4 0.45819 0.22857 84|54443| -1.03919 0 183 1 1 -2.55801 18.44674 96 NLN|PPP Processes 84687 1R9B ADORA2 136|1131| B|CHRM3 GO 1907|367 |EDN2|IT GO:00069 1 -2.55403 M1 1 0 Biological 19 regulation of smooth muscle contraction -2.55403 3.303893 3.656634 24156 67 873 8 0.91638 0.322501 3|6869|69 GA2|TAC -1.03592 0 115 0 0 -3.30059 4.19244 40 Processes 15|9312|9 R1|TBXA2 3649 R|KCNB2| MYOCD ADORA2 135|1021| A|CDK6|D 1600|328 GO AB1|HES1 GO:00487 0|3976|49 1 -2.55316 M1 1 0 Biological 19 astrocyte differentiation -2.55316 3.036963 3.577725 24156 82 873 9 1.030928 0.341867 |LIF|NTRK -1.03592 0 56 0 0 -4.84716 6.385408 08 16|5270|5 Processes 3|SERPIN 354|3081 E2|PLP1|S 2 OX8 CD34|EP 947|2048| HB2|PDG 5156|527 FRA|SERP GO GO:00508 0|6915|70 INE2|TBX 1 -2.55316 M1 1 0 Biological 19 regulation of coagulation -2.55316 3.036963 3.577725 24156 82 873 9 1.030928 0.341867 -1.03592 0 108 0 0 -3.3802 5.825285 18 56|7057|1 A2R|THB Processes 70692|19 D|THBS1| 6527 ADAMTS 18|ANO6 2247|475 FGF2|NEK 1|5073|75 2|PARN|X 20|9104|2 RCC5|RG GO GO:20002 7063|289 N|ANKRD 1 -2.54991 M1 1 0 Biological 19 regulation of DNA biosynthetic process -2.54991 2.669922 3.460625 24156 114 873 11 1.260023 0.37751 -1.0337 0 85 0 0 -3.87201 3.458763 78 84|54464| 1|RGCC|X Processes 79075|80 RN1|DSC 119|8016 C1|PIF1|C 9 TC1 CDO1|CR 1036|138 EB1|CCN 5|1490|29 2|GRIN1| 02|5156|6 GO PDGFRA| GO:00432 935|1089 1 -2.54991 M1 1 0 Biological 19 response to amino acid -2.54991 2.669922 3.460625 24156 114 873 11 1.260023 0.37751 ZEB1|PPA -1.0337 0 165 0 0 -2.70943 2.669922 00 1|56034|8 Processes RGC1A|P 4687|143 DGFC|PP 686|6529 P1R9B|SE 68 SN3|CAST CMKLR1| 1240|190 EDN2|LG GO 7|3958|70 GO:19055 ALS3|THB 1 -2.54553 M1 1 0 Biological 19 macrophage migration -2.54553 3.654542 3.746133 24156 53 873 7 0.801833 0.301847 57|79148| -1.03036 0 42 0 0 -5.75682 3.654542 17 S1|MMP2 Processes 131450|7 8|CD200R 29230 1|CCR2 AGTR2|B 186|655|2 MP7|FGF 247|3280| GO 2|HES1|S GO:00016 4089|409 1 -2.54189 M1 1 0 Biological 19 ureteric bud development -2.54189 2.82348 3.502478 24156 98 873 10 1.145475 0.360151 MAD4|S -1.02879 0 10 0 0 -10.1376 3.952872 57 0|5228|64 Processes MAD5|PG 22|10736| F|SFRP1|S 30812 IX2|SOX8 1062|383 CENPE|KI 2|6456|86 F11|SH3G GO 55|9493|1 L2|DYNLL GO:00198 antigen processing and presentation of 1 -2.54189 M1 1 0 Biological 19 -2.54189 2.82348 3.502478 24156 98 873 10 1.145475 0.360151 1004|241 1|KIF23|KI -1.02879 0 46 0 0 -5.44351 7.281606 86 exogenous peptide antigen via MHC class II Processes 37|26153| F2C|KIF4A 81930|13 |KIF26A|KI 0340 F18A|AP1 BMP7|FZ 655|2535| D2|SFRP1 6422|649 |STIL|SPIN GO 1|6692|85 GO:00140 T1|LMO4| 1 -2.54189 M1 1 0 Biological 19 primary neural tube formation -2.54189 2.82348 3.502478 24156 98 873 10 1.145475 0.360151 43|9585|5 -1.02879 0 64 0 0 -4.46525 3.120688 20 KIF20B|S Processes 7619|131 HROOM3 405|1441 |TRIM71|P 65 RICKLE1 BRCA2|C 675|835|1 ASP2|COL 299|2620| 9A3|GAS2 GO GO:00085 3624|408 |INHBA|S 1 -2.54189 M1 1 0 Biological 19 female gonad development -2.54189 2.82348 3.502478 24156 98 873 10 1.145475 0.360151 -1.02879 0 89 0 0 -3.75072 2.95506 85 9|5156|64 MAD4|PD Processes 22|10468| GFRA|SFR 23414 P1|FST|ZF PM2 ACTN1|A 87|88|215 CTN2|F8| 7|2277|23 VEGFD|F R-HSA- Reactome 35|3690|5 N1|ITGB3| 1 -2.14368 M1 1 0 6 Platelet degranulation -2.14368 2.359466 2.997814 24156 129 873 11 1.260023 0.37751 -0.76946 0 81 0 0 -3.97669 6.510612 114608 Gene Sets 175|7057| PECAM1| 7078|101 THBS1|TI 84|94121 MP3|LHF PL2|SYTL BRCA1|D 672|1789| NMT3B|LI 3976|408 F|SMAD4| 9|4361|47 MRE11|N GO 51|5073|5 EK2|PAR GO:20012 positive regulation of chromosome 1 -2.53893 M1 1 0 Biological 19 -2.53893 2.255715 3.310846 24156 184 873 15 1.718213 0.439813 081|5587| N|PAX7|P -1.02635 0 184 1 1 -2.53893 6.917526 52 organization Processes 7520|872 RKD1|XR 6|9787|10 CC5|EED| 891|5518 DLGAP5| 3|55196 PPARGC1 A|RIF1|RE PRDM1|B 639|655|9 MP7|CD3 47|983|10 4|CDK1|C 03|1021|1 DH5|CDK 266|1385| 6|CNN3|C 2535|328 REB1|FZD 0|3664|36 2|HES1|IR 73|3861|3 F6|ITGA2| 958|3976| KRT14|LG 4089|420 ALS3|LIF|S 8|4233|46 MAD4|M 10|4916|5 EF2C|MET 175|5308| |MYCL|NT GO 5420|562 RK3|PECA GO:00308 1 -2.53818 M1 1 0 Biological 19 epithelial cell differentiation -2.53818 1.548963 3.029813 24156 786 873 44 5.040092 0.740427 9|6498|69 M1|PITX2| -1.02611 0 127 0 0 -3.17736 9.223368 55 Processes 35|6939|7 PODXL|P 132|7852| ROX1|SKI 9317|949 L|ZEB1|TC 7|10413|1 F15|TNFR 0733|107 SF1A|CXC 36|23086| R4|PTER|S 26084|30 LC4A7|YA 812|5550 P1|PLK4|S 6|57619|6 IX2|EXPH 4102|117 5|ARHGE 531|1444 F26|SOX8 55|28421 |MACRO 7|642658 H2A2|SH ROOM3|T EPHB1|EP 2047|204 HB2|GPC 8|2239|29 4|GRIN1|I 02|3706|4 TPKA|ME 208|4916| F2C|NTRK 7058|707 3|THBS2| GO GO:00508 4|9423|11 TIAM1|NT 1 -2.53492 M1 1 0 Biological 19 regulation of synapse structure or activity -2.53492 2.075258 3.241642 24156 240 873 18 2.061856 0.480948 -1.02337 0 63 0 0 -4.50244 10.37629 03 141|2287 N1|IL1RA Processes 1|23237|2 PL1|NLG 3768|260 N1|ARC|F 37|26280| LRT2|SIPA 54674|34 1L1|IL1RA 7730 PL2|LRRN 3|LRRTM1 GO 1462|406 VCAN|LU GO:00300 extracellular matrix structural constituent 1 -2.13258 M1 1 0 Molecular 21 -2.13258 5.030928 3.662629 24156 22 873 4 0.45819 0.22857 0|4969|10 M|OGN|P -0.76946 0 96 0 0 -3.66151 10.37629 21 conferring compression resistance Functions 216 RG4 XIAP|FAS| R-HSA- Reactome 331|355|8 1 -2.13258 M1 1 0 6 RIPK1-mediated regulated necrosis -2.13258 5.030928 3.662629 24156 22 873 4 0.45819 0.22857 TNFSF10| -0.76946 0 141 0 0 -2.97821 18.44674 5213460 Gene Sets 743|8772 FADD XIAP|FAS| R-HSA- Reactome 331|355|8 1 -2.13258 M1 1 0 6 Regulated Necrosis -2.13258 5.030928 3.662629 24156 22 873 4 0.45819 0.22857 TNFSF10| -0.76946 0 141 0 0 -2.97821 18.44674 5218859 Gene Sets 743|8772 FADD ACTN2|C R-HSA- Reactome Unblocking of NMDA receptors, glutamate 88|815|28 AMK2A|G 1 -2.13258 M1 1 0 6 -2.13258 5.030928 3.662629 24156 22 873 4 0.45819 0.22857 -0.76946 0 164 0 0 -2.711 11.06804 438066 Gene Sets binding and activation 90|2902 RIA1|GRI N1 ACTN2|C R-HSA- Reactome Negative regulation of NMDA receptor- 88|815|29 AMK2A|G 1 -2.13258 M1 1 0 6 -2.13258 5.030928 3.662629 24156 22 873 4 0.45819 0.22857 -0.76946 0 164 0 0 -2.711 11.06804 9617324 Gene Sets mediated neuronal transmission 02|22843 RIN1|PPM 1E 2619|574 GAS1|PT Canonical 1 -2.13258 M211 M1 1 0 11 PID HEDGEHOG 2PATHWAY -2.13258 5.030928 3.662629 24156 22 873 4 0.45819 0.22857 4|6491|91 HLH|STIL| -0.76946 0 225 1 1 -2.13258 6.917526 Pathways 653 BOC DAB1|SER 1600|527 GO PINE2|PR GO:00215 0|5629|60 1 -2.53146 M1 1 0 Biological 19 cerebellum morphogenesis -2.53146 4.150515 3.861448 24156 40 873 6 0.687285 0.279617 OX1|ROR -1.02094 0 92 0 0 -3.73382 12.29782 87 95|9928|8 Processes A|KIF14|K 5442 NDC1 ALDH1A3 GO 220|655|5 GO:00485 embryonic camera-type eye |BMP7|PR 1 -2.52312 M1 1 0 Biological 19 -2.52312 4.94109 4.040414 24156 28 873 5 0.572738 0.255402 629|6935| -1.01311 0 7 0 0 -11.4306 6.148912 96 morphogenesis OX1|ZEB1 Processes 7054 |TH ADORA2 A|AHR|CA 135|196|8 SP2|CDK1 35|983|13 |CREB1|G 85|2620|3 AS2|INHB 624|4316| A|MMP7| 4916|515 NTRK3|P GO 6|5563|56 GO:00485 DGFRA|P 1 -2.51915 M1 1 0 Biological 19 rhythmic process -2.51915 1.943385 3.178395 24156 299 873 21 2.405498 0.518571 29|6095|7 -1.00977 0 185 1 1 -2.51915 2.406096 11 RKAA2|PR Processes 054|7079| OX1|ROR 7153|108 A|TH|TIM 91|22871| P4|TOP2 50865|51 A|PPARG 514|7972 C1A|NLG 3 N1|HEBP 1|DTL|SU ACTN2|C CN2|ECT2 88|1490|1 |GPM6B|S 894|2824| MAD4|M 4089|420 EF2C|MET 8|4233|49 |NTRK3|P 16|5156|5 DGFRA|P 629|6387| ROX1|CX GO 6422|745 GO:00329 regulation of actin cytoskeleton CL12|SFR 1 -2.51875 M1 1 0 Biological 19 -2.51875 1.849812 3.141233 24156 359 873 24 2.749141 0.553399 6|9723|10 -1.00977 0 14 0 0 -9.68163 3.166231 56 organization P1|WIPF1| Processes 788|1134 SEMA3E|I 6|22843|2 QGAP2|S 2998|234 YNPO|PP 33|28984| M1E|LIM 29766|50 CH1|RHO 853|5738 Q|RGCC|T 1|84952 MOD3|VI LL|RHOJ| 835|983|1 CASP2|C 021|1030| DK1|CDK 2273|679 6|CDKN2 GO GO:19028 negative regulation of cell cycle G1/S phase 0|7029|74 B|FHL1|A 1 -2.51587 M1 1 0 Biological 19 -2.51587 2.515464 3.380657 24156 132 873 12 1.37457 0.394068 -1.0079 0 30 0 0 -6.32789 4.035223 07 transition 65|28984| URKA|TF Processes 51512|57 DP2|WEE 165|1444 1|RGCC|G 55 TSE1|GJC AGTR2|C RABP2|FH 186|1382| L1|FN1|G 2273|233 OLGA4|IN 5|2803|36 HBA|SMA 24|4089|4 D4|NTRK 916|5167| 3|ENPP1| 5270|579 SERPINE2 5|5931|63 |PTPRJ|RB GO 87|6422|7 BP7|CXCL GO:00015 1 -2.51105 M1 1 0 Biological 19 regulation of cell growth -2.51105 1.774567 3.104536 24156 421 873 27 3.092784 0.58593 852|9423| 12|SFRP1| -1.00367 0 104 0 0 -3.44559 2.082696 58 Processes 9723|992 CXCR4|N 8|10276|1 TN1|SEM 0516|261 A3E|KIF14 53|29948| |NET1|FBL 55031|84 N5|KIF26 687|8500 A|OSGIN 4|93649|1 1|USP47| 51835 PPP1R9B| RERG|MY OCD|CPN GO GO:00009 Cellular condensed nuclear chromosome outer 699|1040 BUB1|ND 1 -2.12745 M1 1 0 20 -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 25 0 0 -7.23866 13.83505 42 Compone kinetochore 3 C80 nts AGTR2|B 186|655|2 MP7|FGF 247|3280| GO 2|HES1|S GO:00721 4089|409 1 -2.50959 M1 1 0 Biological 19 mesonephric epithelium development -2.50959 2.79496 3.465316 24156 99 873 10 1.145475 0.360151 MAD4|S -1.00367 0 10 0 0 -10.1376 3.952872 63 0|5228|64 Processes MAD5|PG 22|10736| F|SFRP1|S 30812 IX2|SOX8 CORUM:2 BRCA1|M 1 -2.12745 M1 1 0 CORUM 33 BRCA1-RAD50-MRE11-NBS1 complex -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 672|4361 -0.76946 0 70 0 0 -4.32747 27.6701 02 RE11 CORUM:2 BRCA1|O 1 -2.12745 M1 1 0 CORUM 33 BRCA1-IRIS-pre-replication complex -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 672|4998 -0.76946 0 70 0 0 -4.32747 27.6701 210 RC1 CORUM:2 BRCA1|L 1 -2.12745 M1 1 0 CORUM 33 LMO4-BRCA1-CTIP-LDB1 complex -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 672|8543 -0.76946 0 70 0 0 -4.32747 27.6701 214 MO4 CORUM:2 BARD1|B 1 -2.12745 M1 1 0 CORUM 33 BRCA1 A complex -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 580|672 -0.76946 0 70 0 0 -4.32747 27.6701 786 RCA1 CORUM:2 BARD1|B 1 -2.12745 M1 1 0 CORUM 33 BRCA1 C complex -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 580|672 -0.76946 0 70 0 0 -4.32747 27.6701 787 RCA1 CORUM:9 BRCA1|M 1 -2.12745 M1 1 0 CORUM 33 BRCA1-RAD50-MRE11-NBS1 complex -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 672|4361 -0.76946 0 70 0 0 -4.32747 27.6701 64 RE11 CORUM:2 2335|369 FN1|ITGB 1 -2.12745 M1 1 0 CORUM 33 ITGA2B-ITGB3-FN1-TGM2 complex -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 111 0 0 -3.35124 18.44674 376 0 3 AGTR2|B 186|655|2 MP7|FGF 247|3280| GO 2|HES1|S GO:00721 4089|409 1 -2.50959 M1 1 0 Biological 19 mesonephric tubule development -2.50959 2.79496 3.465316 24156 99 873 10 1.145475 0.360151 MAD4|S -1.00367 0 10 0 0 -10.1376 3.952872 64 0|5228|64 Processes MAD5|PG 22|10736| F|SFRP1|S 30812 IX2|SOX8 ACTN2|C RHBP|ED 88|1393|1 N3|STOM 908|2040| |EPHB2|F 2048|227 HL1|GRIA 3|2890|29 1|GRIN1| 02|3739|3 KCNA4|K 759|3762| CNJ2|KC 4208|517 NJ5|MEF2 4|6328|70 C|PDZK1| 57|9104|9 GO SCN3A|T GO:00347 312|1036 1 -2.50766 M1 1 0 Biological 19 regulation of ion transmembrane transport -2.50766 1.715089 3.077205 24156 484 873 30 3.436426 0.616528 HBS1|RG -1.00224 0 45 0 0 -5.5147 9.223368 65 9|10891|2 Processes N|KCNB2| 2871|232 CACNG2| 37|27133| PPARGC1 54997|57 A|NLGN1| 165|8103 ARC|KCN 3|84329|1 H5|TESC| 17531|12 GJC2|KCN 6755|196 H6|HVCN 527|7292 1|TMC1|L 30 RRC38|A NO6|CCR GO TNFRSF1 GO:00029 Cellular tumor necrosis factor receptor superfamily 7132|713 1 -2.12745 M1 1 0 20 -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 A|TNFRSF -0.76946 0 113 0 0 -3.34087 13.83505 47 Compone complex 3 1B nts CORUM:5 DISC complex (FAS, FADD, CASP8, CFLAR), FAS|FAD 1 -2.12745 M1 1 0 CORUM 33 -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 355|8772 -0.76946 0 141 0 0 -2.97821 18.44674 799 membrane-associated, CD95L induced D CORUM:5 FAS|FAD 1 -2.12745 M1 1 0 CORUM 33 FAS-FADD-CASP8-CASP10 complex -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 355|8772 -0.76946 0 141 0 0 -2.97821 18.44674 859 D COL5A1| 1289|129 COL7A1| GO GO:00017 4|1295|23 COL8A1|F 1 -2.49872 M1 1 0 Biological 19 endoderm formation -2.49872 3.586865 3.684982 24156 54 873 7 0.801833 0.301847 -0.99432 0 77 0 0 -4.11211 18.44674 06 35|3624|3 N1|INHB Processes 909|3914 A|LAMA3| LAMB3 MRE11|T 4361|715 OP2A|TRI GO 3|9319|80 GO:00358 P13|RMI1| 1 -2.49872 M1 1 0 Biological 19 homologous recombination -2.49872 3.586865 3.684982 24156 54 873 7 0.801833 0.301847 010|8393 -0.99432 0 156 0 0 -2.83533 5.764605 25 HDAC10| Processes 3|84057|1 MND1|E 46956 ME1 CHRM3|C 1131|139 RHBP|DN 3|1789|18 MT3B|DR 16|2902|3 GO D5|GRIN1 GO:00603 269|5179| 1 -2.48893 M1 1 0 Biological 19 response to ammonium ion -2.48893 2.496551 3.351157 24156 133 873 12 1.37457 0.394068 |HRH1|PE -0.98604 0 123 0 0 -3.23644 5.764605 59 7074|785 Processes NK|TIAM 2|8772|84 1|CXCR4| 687|8539 FADD|PP 7 P1R9B|RG PRDM1|B 639|675|2 RCA2|GA 620|3624| S2|INHBA 4089|409 |SMAD4|S 0|4603|50 MAD5|M 10|5073|6 YBL1|CLD 498|6790| N11|PAR 7130|715 N|SKIL|AU 3|7272|91 RKA|TNF 04|9232|9 AIP6|TOP 319|1014 2A|TTK|R 9|10468|1 GN|PTTG 0491|107 1|TRIP13| GO 32|23397| ADGRG2| GO:00072 1 -2.48823 M1 1 0 Biological 19 gamete generation -2.48823 1.576644 3.002335 24156 702 873 40 4.581901 0.707671 23598|25 FST|CRTA -0.98585 0 114 0 0 -3.31277 5.355504 76 Processes 886|2606 P|TCFL5| 4|30812|5 NCAPH|P 5706|561 ATZ1|PO 55|57082| C1A|RAI1 57650|58 4|SOX8|N 494|8193 DC1|TEX1 0|84690|8 4|KNL1|CI 4930|853 P2A|JAM 15|85413| 2|KIF18A| 91646|13 SPATA22| 5138|254 MASTL|P 394|2592 AQR8|SL 66 C22A16|T DRD12|P ACTN1|A DORA2A| 87|135|94 CD34|EN 7|954|204 TPD2|EPH 8|2157|23 B2|F8|FLI1 13|2814|3 |GP5|ITG 673|3690| A2|ITGB3| 5156|527 GO PDGFRA| GO:00075 0|6915|70 1 -2.48454 M1 1 0 Biological 19 hemostasis -2.48454 1.866312 3.119733 24156 341 873 23 2.634593 0.542066 SERPINE2 -0.98265 0 108 0 0 -3.3802 5.825285 99 56|7057|7 Processes |TBXA2R| 980|8357| THBD|TH 23414|50 BS1|TFPI2 808|1391 |H3C10|Z 89|17069 FPM2|AK 2|196527| 3|DGKK|A 653604 DAMTS18 |ANO6|H AGTR2|C 186|1393| RHBP|DR 1816|190 GO D5|EDN2| GO:00508 7|1908|36 1 -2.48174 M1 1 0 Biological 19 endocrine process -2.48174 2.964654 3.492696 24156 84 873 9 1.030928 0.341867 EDN3|IN -0.98036 0 187 1 1 -2.48174 18.44674 86 24|4089|5 Processes HBA|SMA 125|1148 D4|PCSK5 99 |C1QTNF 835|983|4 CASP2|C 361|6790| DK1|MRE GO 7029|289 11|AURK GO:00447 1 -2.47777 M1 1 0 Biological 19 mitotic DNA damage checkpoint -2.47777 2.76701 3.428614 24156 100 873 10 1.145475 0.360151 84|51512| A|TFDP2| -0.9769 0 30 0 0 -6.32789 4.035223 73 Processes 63967|14 RGCC|GT 4455|146 SE1|CLSP 956 N|E2F7|E ADORA2 R-HSA- Reactome 1 -2.12745 M1 1 0 6 Adenosine P1 receptors -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 135|136 A|ADORA -0.76946 0 171 0 0 -2.66202 13.83505 417973 Gene Sets 2B GO GO:00012 RNA polymerase II transcription cofactor 1385|477 CREB1|NF 1 -2.12745 M1 1 0 Molecular 21 -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 178 0 0 -2.59562 18.44674 24 binding 2 ATC1 Functions 672|5931| BRCA1|RB GO GO:00703 6241|702 BP7|RRM 1 -2.47599 M1 1 0 Biological 19 negative regulation of G0 to G1 transition -2.47599 4.049283 3.783879 24156 41 873 6 0.687285 0.279617 -0.97635 0 142 0 0 -2.96836 11.06804 17 9|8317|87 2|TFDP2| Processes 26 CDC7|EE GO GO:00317 1907|190 EDN2|ED 1 -2.12745 M1 1 0 Molecular 21 bombesin receptor binding -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 187 0 0 -2.48174 18.44674 05 8 N3 Functions R-HSA- Reactome 3624|104 INHBA|FS 1 -2.12745 M1 1 0 6 Antagonism of Activin by Follistatin -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 197 0 0 -2.41795 18.44674 2473224 Gene Sets 68 T

R-HSA- Reactome TFAP2 (AP-2) family regulates transcription 5308|702 PITX2|TFA 1 -2.12745 M1 1 0 6 -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 198 0 0 -2.41795 18.44674 8866906 Gene Sets of other transcription factors 2 P2C GO GO:00355 sequestering of extracellular ligand from 2200|220 FBN1|FBN 1 -2.47423 M1 1 0 Biological 19 -2.47423 9.223368 4.777828 24156 9 873 3 0.343643 0.198061 -0.97635 0 24 0 0 -7.35548 20.75258 81 receptor 1|4052 2|LTBP1 Processes CORUM:1 SNX complex (SNX1, SNX1a, SNX2, SNX4, 5156|664 PDGFRA| 1 -2.12745 M1 1 0 CORUM 33 -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 229 1 1 -2.12745 13.83505 096 PDGFRA) 2 SNX1 R-HSA- Reactome Metabolism of ingested H2SeO4 and 7296|906 TXNRD1| 1 -2.12745 M1 1 0 6 -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 230 1 1 -2.12745 13.83505 2408550 Gene Sets H2SeO3 into H2Se 1 PAPSS1 GO GO:00353 Cellular 23379|79 1 -2.12745 M1 1 0 20 histone locus body -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 ICE1|ICE2 -0.76946 0 231 1 1 -2.12745 13.83505 63 Compone 664 nts GO ALDH1A3 GO:00161 220|8854| 1 -2.47423 M1 1 0 Biological 19 diterpenoid biosynthetic process -2.47423 9.223368 4.777828 24156 9 873 3 0.343643 0.198061 |ALDH1A -0.97635 0 131 0 0 -3.08989 10.37629 02 157506 Processes 2|RDH10 GO BHMT|D GO:00196 635|2995 1 -2.47423 M1 1 0 Biological 19 choline metabolic process -2.47423 9.223368 4.777828 24156 9 873 3 0.343643 0.198061 MGDH|C -0.97635 0 134 0 0 -3.06206 27.6701 95 8|55349 Processes HDH ADORA2 A|AGTR2| 135|186|3 XIAP|CAL 31|794|10 B2|CDH5| 03|1240|1 CMKLR1| 312|1317| COMT|SL 1356|181 C31A1|CP 6|1907|19 |DRD5|ED 08|2247|2 N2|EDN3| 512|2840| FGF2|FTL| 2846|289 GPR17|LP 0|2902|32 AR4|GRIA 63|3357|3 1|GRIN1| 759|4089| GO HPX|HTR GO:00550 5156|634 1 -2.47123 M1 1 0 Biological 19 cation homeostasis -2.47123 1.553669 2.978585 24156 748 873 42 4.810997 0.724275 2B|KCNJ2 -0.97385 0 94 0 0 -3.67332 2.548562 80 1|6387|68 Processes |SMAD4|P 69|6915|7 DGFRA|S 223|7852| CO1|CXC 9104|949 L12|TACR 7|10590|1 1|TBXA2R 1346|228 |TRPC4|C 21|30001| XCR4|RG 51554|54 N|SLC4A7 757|5501 |SCGN|SY 3|64072|8 NPO|RAS 3959|261 A3|ERO1 729|7292 A|ACKR4| 30 FAM20A| MCUB|CD CMKLR1| 1240|190 EDN2|ED 7|1908|22 N3|VEGF GO 77|5228|6 GO:00026 D|PGF|CX 1 -2.46222 M1 1 0 Biological 19 regulation of leukocyte chemotaxis -2.46222 2.601463 3.362349 24156 117 873 11 1.260023 0.37751 387|7057| -0.96694 0 42 0 0 -5.75682 3.654542 88 CL12|THB Processes 9547|791 S1|CXCL1 48|19652 4|MMP28 7|729230 |ANO6|C BRCA2|C 675|835|1 ASP2|COL 299|2620| 9A3|GAS2 GO 3624|408 GO:00466 |INHBA|S 1 -2.46222 M1 1 0 Biological 19 female sex differentiation -2.46222 2.601463 3.362349 24156 117 873 11 1.260023 0.37751 9|5156|64 -0.96694 0 89 0 0 -3.75072 2.95506 60 MAD4|PD Processes 22|10184| GFRA|SFR 10468|23 P1|LHFPL 414 2|FST|ZFP CYP1B1|P GO 1545|515 GO:00612 retina vasculature development in camera- DGFRA|R 1 -2.46134 M1 1 0 Biological 19 -2.46134 6.148912 4.231479 24156 18 873 4 0.45819 0.22857 6|57381|2 -0.96694 0 189 1 1 -2.46134 9.223368 98 type eye HOJ|LAM Processes 84217 A1 ACTN1|A 87|88|227 CTN2|FHL 5|10529|1 3|NEBL|SY GO 1346|272 NPO|PDLI GO:00300 Cellular 1 -2.11926 M1 1 0 20 Z disc -2.11926 2.341316 2.969295 24156 130 873 11 1.260023 0.37751 95|29780| M3|PARV -0.76415 0 48 0 0 -5.29557 3.217454 18 Compone 57159|91 B|TRIM54| nts 624|9197 NEXN|MY 7|113146 OZ3|AHN AK2 GO 1317|135 SLC31A1| GO:00068 1 -2.46134 M1 1 0 Biological 19 copper ion transport -2.46134 6.148912 4.231479 24156 18 873 4 0.45819 0.22857 6|6341|26 CP|SCO1| -0.96694 0 190 1 1 -2.46134 9.223368 25 Processes 1729 STEAP2 ADORA2 A|AGTR2| 135|186|2 ALDH1A3 20|238|13 |ALK|CO 12|1385|1 MT|CREB 393|1600| 1|CRHBP| 1816|204 DAB1|DR 8|2890|29 D5|EPHB2 02|3269|3 |GRIA1|G 357|4208| RIN1|HRH 4885|488 1|HTR2B| 6|5179|52 MEF2C|N GO 70|6387|6 PTX2|NPY GO:00076 1 -2.45737 M1 1 0 Biological 19 behavior -2.45737 1.614463 2.993888 24156 617 873 36 4.123711 0.672965 939|7054| 1R|PENK| -0.96396 0 49 0 0 -5.27843 3.609144 10 Processes 7057|877 SERPINE2 2|11346|2 |CXCL12| 2871|232 TCF15|TH 37|56172| |THBS1|F 64072|80 ADD|SYN 010|8468 PO|NLGN 7|139411| 1|ARC|AN 164312|2 KH|CDH2 85671|34 3|RMI1|P 7730|389 PP1R9B|P 400 TCHD1|L RRN4|RN F180|LRR ADORA2 A|ADORA 2B|AGTR2 |CHRM3| 135|136|1 COMT|CR 86|1131|1 HBP|CCN 312|1393| 2|EDN2|E 1490|190 DN3|GRI 7|1908|29 N1|HRH1| 02|3269|3 INHBA|IT 624|3673| GA2|KCN 3759|376 J2|KCNJ5| 2|4089|48 SMAD4|N 85|6869|6 GO PTX2|TAC GO:00440 915|7054| 1 -2.45737 M1 1 0 Biological 19 regulation of system process -2.45737 1.614463 2.993888 24156 617 873 36 4.123711 0.672965 R1|TBXA2 -0.96396 0 61 0 0 -4.53228 18.44674 57 7132|713 Processes R|TH|TNF 3|7135|71 RSF1A|TN 36|7139|7 FRSF1B|T 140|9312| NNI1|TN 10369|10 NI2|TNNT 659|1089 2|TNNT3| 1|22871|5 KCNB2|C 7616|584 ACNG2|C 94|64091| ELF2|PPA 93649|11 RGC1A|N 4899 LGN1|TS HZ3|JAM 2|POPDC 2|MYOCD ADORA2 135|186|2 A|AGTR2| 91|580|94 SLC25A4| 7|983|189 BARD1|C 4|2040|23 D34|CDK 35|3357|4 1|ECT2|ST 155|5116| OM|FN1| 5174|536 HTR2B|M 6|5600|64 BP|PCNT| 22|7029|7 PDZK1|P 074|7133| MAIP1|M 8111|876 APK11|SF 7|9324|95 RP1|TFDP GO 85|9648|9 2|TIAM1| GO:00702 regulation of establishment of protein 1 -2.45423 M1 1 0 Biological 19 -2.45423 1.54121 2.95942 24156 772 873 43 4.925544 0.732406 662|1012 TNFRSF1 -0.96291 0 133 0 0 -3.08066 2.143459 01 localization Processes 5|10631|2 B|GPR68| 3086|233 RIPK2|HM 79|27063| GN3|KIF2 28984|29 0B|GCC2| 969|5151 CEP135|R 2|51715|5 ASGRP1|P 5835|796 OSTN|EX 79|80184| PH5|ICE1| 84455|85 ANKRD1| 459|9146 RGCC|MD 1|94121|1 FIC|GTSE 14899|13 1|RAB23| 1450 CENPJ|VT CN1|CEP BMP7|CD GO 655|947|3 GO:00614 34|HES1| 1 -2.45386 M1 1 0 Biological 19 renal system vasculature development -2.45386 4.770707 3.934245 24156 29 873 5 0.572738 0.255402 280|5156| -0.96291 0 119 0 0 -3.27941 18.44674 37 PDGFRA| Processes 5175 PECAM1 BMP7|CD GO 655|947|3 GO:00614 34|HES1| 1 -2.45386 M1 1 0 Biological 19 kidney vasculature development -2.45386 4.770707 3.934245 24156 29 873 5 0.572738 0.255402 280|5156| -0.96291 0 119 0 0 -3.27941 18.44674 40 PDGFRA| Processes 5175 PECAM1 AGTR2|C ALB2|CD 186|794|1 H5|CMKL 003|1240| R1|SLC31 1317|135 A1|CP|DR 6|1816|19 D5|EDN2| 07|1908|2 EDN3|FG 247|2512| F2|FTL|GP 2840|284 R17|LPAR 6|2890|29 4|GRIA1| 02|3263|3 GRIN1|HP GO 357|3759| X|HTR2B| GO:00068 1 -2.44859 M1 1 0 Biological 19 cellular metal ion homeostasis -2.44859 1.624922 2.991249 24156 596 873 35 4.009164 0.663949 4089|515 KCNJ2|S -0.95862 0 94 0 0 -3.67332 2.548562 75 Processes 6|6341|63 MAD4|PD 87|6869|6 GFRA|SC 915|7223| O1|CXCL 7852|910 12|TACR1 4|10590|1 |TBXA2R| 1346|228 TRPC4|CX 21|30001| CR4|RGN| 51554|55 SCGN|SY 013|6407 NPO|RAS 2|729230 A3|ERO1 A|ACKR4| MCUB|CD ACTC1|A CTN1|AC 70|87|88| TN2|CCN 1490|423 2|MET|PR 3|5629|63 OX1|CXC 87|6422|7 L12|SFRP 456|9645| 1|WIPF1| 9938|105 MICAL2|A 29|10788| RHGAP25 11346|22 |NEBL|IQ GO GO:00070 843|2299 GAP2|SY 1 -2.44163 M1 1 0 Biological 19 actin filament organization -2.44163 1.753739 3.039261 24156 426 873 27 3.092784 0.58593 -0.95215 0 14 0 0 -9.68163 3.166231 15 8|23433|2 NPO|PPM Processes 7295|289 1E|LIMCH 84|29766| 1|RHOQ| 50853|57 PDLIM3|R 381|5761 GCC|TM 9|84687|8 OD3|VILL| 4940|849 RHOJ|SH 52|35984 ROOM3|P 5 PP1R9B|C ORO6|CG NL1|RFLN VCAN|GP 1462|223 C4|FGF2| 9|2247|31 HMMR|L 61|4060|4 UM|OGN| GO 969|7358| UGDH|HS GO:00060 1 -2.42278 M1 1 0 Biological 19 aminoglycan metabolic process -2.42278 2.265389 3.215461 24156 171 873 14 1.603666 0.425147 9653|110 2ST1|KER -0.95179 0 96 0 0 -3.66151 10.37629 22 Processes 81|51363| A|CHST15 55790|80 |CSGALN 760|9301 ACT1|ITIH 0|133584 5|B3GNT7 |EGFLAM XIAP|BIRC 331|332|7 5|C4A|CO 20|1294|2 L7A1|FN1 335|5270| |SERPINE 6692|707 2|SPINT1| GO GO:00611 8|7079|79 TIMP3|TI 1 -2.09846 M1 1 0 Molecular 21 peptidase regulator activity -2.09846 1.967652 2.823717 24156 225 873 16 1.832761 0.453972 -0.74657 0 116 0 0 -3.2998 2.23146 34 80|9232|7 MP4|TFPI Functions 9444|807 2|PTTG1| 60|11716 BIRC7|ITI 6|124857| H5|WFIKK 140902 N1|WFIKK N2|R3HD GO GO:00329 1894|958 ECT2|KIF2 1 -2.41795 M1 1 0 Biological 19 regulation of cytokinetic process -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 102 0 0 -3.49473 18.44674 54 5 0B Processes GO GO:00720 CD34|PEC 1 -2.41795 M1 1 0 Biological 19 glomerular endothelium development -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 947|5175 -0.95179 0 119 0 0 -3.27941 18.44674 11 AM1 Processes GO GO:00065 635|2995 BHMT|D 1 -2.41795 M1 1 0 Biological 19 amino-acid betaine catabolic process -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 134 0 0 -3.06206 27.6701 79 8 MGDH Processes GO GO:00313 regulation of sulfur amino acid metabolic BHMT|CO 1 -2.41795 M1 1 0 Biological 19 -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 635|1312 -0.95179 0 134 0 0 -3.06206 27.6701 35 process MT Processes GO GO:00356 CD8-positive, alpha-beta T cell 8772|729 FADD|CC 1 -2.41795 M1 1 0 Biological 19 -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 152 0 0 -2.8845 27.6701 97 extravasation 230 R2 Processes GO GO:20004 8772|729 FADD|CC 1 -2.41795 M1 1 0 Biological 19 positive regulation of T cell extravasation -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 152 0 0 -2.8845 27.6701 09 230 R2 Processes GO 6790|798 AURKA|B GO:00726 Cellular 1 -2.09129 M1 1 0 20 meiotic spindle -2.09129 6.917526 3.970245 24156 12 873 3 0.343643 0.198061 66|25926 ORA|ASP -0.74507 0 80 0 0 -4.01173 9.223368 87 Compone 6 M nts GO GO:20004 regulation of CD8-positive, alpha-beta T 8772|729 FADD|CC 1 -2.41795 M1 1 0 Biological 19 -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 152 0 0 -2.8845 27.6701 49 cell extravasation 230 R2 Processes GO GO:00720 BMP7|SM 1 -2.41795 M1 1 0 Biological 19 nephrogenic mesenchyme development -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 655|4089 -0.95179 0 153 0 0 -2.8845 27.6701 76 AD4 Processes R-HSA- Reactome Purine ribonucleoside monophosphate 2618|547 GART|PP 1 -2.09129 M1 1 0 6 -2.09129 6.917526 3.970245 24156 12 873 3 0.343643 0.198061 -0.74507 0 135 0 0 -3.06206 13.83505 73817 Gene Sets biosynthesis 1|10606 AT|PAICS CAMK2A| R-HSA- Reactome CaMK IV-mediated phosphorylation of 815|1385| 1 -2.09129 M1 1 0 6 -2.09129 6.917526 3.970245 24156 12 873 3 0.343643 0.198061 CREB1|KP -0.74507 0 164 0 0 -2.711 11.06804 111932 Gene Sets CREB 3838 NA2 GO GO:19031 54443|84 ANLN|PP 1 -2.41795 M1 1 0 Biological 19 protein localization to actin cytoskeleton -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 183 0 0 -2.55801 18.44674 19 687 P1R9B Processes GO GO:00359 5308|642 PITX2|SC 1 -2.41795 M1 1 0 Biological 19 deltoid tuberosity development -2.41795 18.44674 5.851678 24156 3 873 2 0.229095 0.161809 -0.95179 0 198 1 1 -2.41795 18.44674 93 658 X Processes 1062|383 CENPE|KI 2|6456|86 F11|SH3G GO 55|9493|1 L2|DYNLL GO:00024 antigen processing and presentation of 1 -2.41554 M1 1 0 Biological 19 -2.41554 2.712755 3.356548 24156 102 873 10 1.145475 0.360151 1004|241 1|KIF23|KI -0.95032 0 46 0 0 -5.44351 7.281606 95 peptide antigen via MHC class II Processes 37|26153| F2C|KIF4A 81930|13 |KIF26A|KI 0340 F18A|AP1 22974|26 TPX2|RSL CORUM:3 1 -2.09129 M1 1 0 CORUM 33 Parvulin-associated pre-rRNP complex -2.09129 6.917526 3.970245 24156 12 873 3 0.343643 0.198061 156|8405 1D1|MND -0.74507 0 236 1 1 -2.09129 6.917526 047 7 1 GO 133584|1 EGFLAM| GO:00056 Cellular 1 -2.09129 M1 1 0 20 interstitial matrix -2.09129 6.917526 3.970245 24156 12 873 3 0.343643 0.198061 51887|37 CCDC80| -0.74507 0 237 1 1 -2.09129 6.917526 14 Compone 5567 VWC2 nts ACTC1|A 70|88|186 CTN2|AG GO |983|4089 TR2|CDK1 GO:00550 1 -2.41275 M1 1 0 Biological 19 cardiac muscle cell development -2.41275 2.895708 3.410153 24156 86 873 9 1.030928 0.341867 |5156|562 |SMAD4|P -0.94891 0 13 0 0 -9.83559 6.28866 13 Processes 9|10529|5 DGFRA|P 7538 ROX1|NE BL|ALPK3 DTYMK|M 1841|420 EF2C|CXC 8|9547|10 L14|KLHL GO 324|3081 GO:00454 41|SOX8| 1 -2.41275 M1 1 0 Biological 19 myoblast differentiation -2.41275 2.895708 3.410153 24156 86 873 9 1.030928 0.341867 2|91653|9 -0.94891 0 124 0 0 -3.22859 6.58812 45 BOC|MY Processes 3649|144 OCD|PRIC 165|2021 KLE1|RAN 51 BP3L ADORA2 B|ALK|FAS 136|238|3 |BMP7|CD 55|655|98 K1|CCN2| 3|1490|18 DUSP7|E 49|1908|2 DN3|EPH 047|2048| B1|EPHB2 2122|224 |MECOM| 7|2324|23 FGF2|FLT 35|3357|3 4|FN1|HT 672|3976| R2B|ITGA 4089|421 1|LIF|SMA 4|4916|51 D4|MAP3 56|5600|5 GO K1|NTRK3 GO:00434 795|6422| 1 -2.41051 M1 1 0 Biological 19 regulation of MAPK cascade -2.41051 1.541305 2.924104 24156 754 873 42 4.810997 0.724275 |PDGFRA| -0.94748 0 18 0 0 -7.89792 2.69514 08 7057|707 Processes MAPK11| 4|7078|78 PTPRJ|SF 52|8325|8 RP1|THBS 767|1012 1|TIAM1| 5|10454|1 TIMP3|CX 1072|299 CR4|FZD8 69|55816| |RIPK2|RA 56034|57 SGRP1|TA 608|7944 B1|DUSP1 4|152110| 4|MDFIC| 285016|3 DOK5|PD 88121|38 GFC|JCAD 9400 |BIRC7|NE K10|ALKA GYPC|HB 2995|303 A1|MET|P KEGG 9|4233|51 1 -2.08883 hsa05144 M1 1 0 24 Malaria -2.08883 3.388176 3.24029 24156 49 873 6 0.687285 0.279617 ECAM1|T -0.74401 0 238 1 1 -2.08883 3.388176 Pathway 75|7057|7 HBS1|THB 058 S2 CD34|CD 947|1003| H5|SMAD 4089|423 4|MET|PE 3|5175|56 CAM1|PR GO GO:00031 29|6935|7 OX1|ZEB1 1 -2.41 M1 1 0 Biological 19 endothelium development -2.41 2.44148 3.264244 24156 136 873 12 1.37457 0.394068 -0.94748 0 127 0 0 -3.17736 9.223368 58 132|7852| |TNFRSF1 Processes 26084|54 A|CXCR4| 567|6410 ARHGEF2 2 6|DLL4|T NMD CDH5|CD 1003|100 H7|CDH9| 5|1007|10 R-HSA- Reactome CDH10|C 1 -2.0881 M1 1 0 6 Cell-cell junction organization -2.0881 3.026418 3.143212 24156 64 873 7 0.801833 0.301847 08|1009|5 -0.74398 0 32 0 0 -6.28754 6.917526 421270 Gene Sets DH11|CL 010|8461 DN11|PA 2 RD6B 186|655|5 AGTR2|B GO 228|6422| MP7|PGF| GO:00606 regulation of morphogenesis of a 1 -2.40856 M1 1 0 Biological 19 -2.40856 3.458763 3.56692 24156 56 873 7 0.801833 0.301847 10736|23 SFRP1|SIX -0.94748 0 10 0 0 -10.1376 3.952872 88 branching structure Processes 213|3081 2|SULF1|S 2 OX8 XIAP|BIRC 331|332|7 5|C4A|CO 20|1294|5 L7A1|SER 270|6692| PINE2|SPI GO 7078|707 NT1|TIMP GO:00611 1 -2.08569 M1 1 0 Molecular 21 endopeptidase regulator activity -2.08569 2.071559 2.848413 24156 187 873 14 1.603666 0.425147 9|7980|92 3|TIMP4|T -0.74227 0 116 0 0 -3.2998 2.23146 35 Functions 32|79444| FPI2|PTT 80760|11 G1|BIRC7| 7166|124 ITIH5|WFI 857 KKN1|WFI KKN2 835|983|6 CASP2|C GO DNA damage response, signal transduction 790|7029| DK1|AUR GO:00069 1 -2.40856 M1 1 0 Biological 19 by p53 class mediator resulting in cell cycle -2.40856 3.458763 3.56692 24156 56 873 7 0.801833 0.301847 28984|51 KA|TFDP2 -0.94748 0 30 0 0 -6.32789 4.035223 77 Processes arrest 512|1444 |RGCC|GT 55 SE1|E2F7 1600|261 DAB1|GA 8|2902|70 RT|GRIN1 54|9928|1 |TH|KIF14| GO GO:00219 0460|264 TACC3|L 1 -2.40566 M1 1 0 Biological 19 cerebral cortex development -2.40566 2.557741 3.298524 24156 119 873 11 1.260023 0.37751 -0.94504 0 78 0 0 -4.09519 2.557741 87 68|54820| HX6|NDE Processes 79648|84 1|MCPH1| 687|2592 PPP1R9B| 66 ASPM CASP2|C 835|894|9 CND2|CD 83|1021|1 K1|CDK6| 030|2273| CDKN2B| 6790|702 GO FHL1|AUR GO:19028 regulation of cell cycle G1/S phase 9|7465|83 1 -2.40034 M1 1 0 Biological 19 -2.40034 2.118285 3.144064 24156 209 873 16 1.832761 0.453972 KA|TFDP2 -0.94136 0 30 0 0 -6.32789 4.035223 06 transition 18|9928|2 Processes |WEE1|CD 7085|289 C45|KIF14 84|51512| |MTBP|RG 57165|14 CC|GTSE1 4455 |GJC2|E2F AGTR2|C 186|1003| DH5|ITGA 3672|367 1|ITGA2|L 3|3958|42 GALS3|M 08|9104|9 EF2C|RG GO 814|2350 GO:00353 N|SFI1|RI 1 -2.40034 M1 1 0 Biological 19 regulation of dephosphorylation -2.40034 2.118285 3.144064 24156 209 873 16 1.832761 0.453972 4|55125|5 -0.94136 0 199 1 1 -2.40034 2.76701 03 MBP2|CE Processes 7082|577 P192|KNL 18|84687| 1|PPP4R4| 84930|15 PPP1R9B| 7313|392 MASTL|C 617 DCA2|ELF 983|4751| CDK1|NE 5116|865 K2|PCNT| 5|9662|98 DYNLL1|C 14|10733| EP135|SFI GO GO:01400 organelle localization by membrane 54820|55 1|PLK4|N 1 -2.40016 M1 1 0 Biological 19 -2.40016 2.252218 3.19135 24156 172 873 14 1.603666 0.425147 -0.94136 0 12 0 0 -10.0997 6.06468 56 tethering 125|5583 DE1|CEP1 Processes 5|79441|8 92|CENPJ| 0184|121 HAUS3|C 441|3472 EP290|NE 40 DD1|KIF2 ADORA2 B|CHRM3 136|1131| |CCN2|ED 1490|190 N2|ITGA2 7|3673|37 GO |KCNJ2|T GO:00069 59|6869|6 1 -2.40016 M1 1 0 Biological 19 regulation of muscle contraction -2.40016 2.252218 3.19135 24156 172 873 14 1.603666 0.425147 ACR1|TBX -0.94136 0 61 0 0 -4.53228 18.44674 37 915|7135| Processes A2R|TNNI 7136|713 1|TNNI2|T 9|7140|93 NNT2|TN 12|93649 NT3|KCN B2|MYOC CYP1B1|F 1545|220 BN1|ITGA GO 0|3673|36 GO:00336 2|ITGB3|I 1 -2.39619 M1 1 0 Biological 19 cell adhesion mediated by integrin -2.39619 3.117758 3.460377 24156 71 873 8 0.91638 0.322501 90|3691|3 -0.93784 0 146 0 0 -2.93585 3.952872 27 TGB4|LIF| Processes 976|5420| PODXL|TE 54997 SC ITGA2|SE 3673|527 GO RPINE2|C GO:00509 detection of mechanical stimulus involved 0|6387|78 1 -2.38759 M1 1 0 Biological 19 -2.38759 4.611684 3.832824 24156 30 873 5 0.572738 0.255402 XCL12|CX -0.9297 0 151 0 0 -2.8845 27.6701 74 in sensory perception 52|11753 Processes CR4|TMC 1 1 ALDH1A3 220|2048| |EPHB2|F 2535|562 ZD2|PRO GO 9|6935|94 GO:00424 X1|ZEB1| 1 -2.38511 M1 1 0 Biological 19 inner ear morphogenesis -2.38511 2.686418 3.321164 24156 103 873 10 1.145475 0.360151 23|51141| -0.92858 0 7 0 0 -11.4306 6.148912 72 NTN1|INS Processes 53904|80 IG2|MYO 184|1330 3A|CEP29 60 0|OTOP1 BMP7|GP 655|2882| X7|HBA1| 3039|574 PTGS1|TX GO 2|7296|91 GO:00988 NRD1|RG 1 -2.38511 M1 1 0 Biological 19 cellular oxidant detoxification -2.38511 2.686418 3.321164 24156 103 873 10 1.145475 0.360151 04|10516| -0.92858 0 120 0 0 -3.26614 6.385408 69 N|FBLN5| Processes 10587|13 TXNRD2| 7902|140 PXDNL|S 809 RXN1 CASP2|EC 835|1894| T2|OMG| 4974|707 TIAM1|RI R-HSA- Reactome 4|8767|10 1 -2.07171 M1 1 0 6 p75 NTR receptor-mediated signalling -2.07171 2.567329 2.995011 24156 97 873 9 1.030928 0.341867 PK2|NET1 -0.73212 0 95 0 0 -3.66655 2.902458 193704 Gene Sets 276|2342 |ITGB3BP| 1|26084|5 ARHGEF2 0650 6|ARHGE 1894|224 ECT2|FGF 7|2277|33 2|VEGFD| GO GO:00517 57|5228|9 HTR2B|P 1 -2.37912 M1 1 0 Biological 19 positive regulation of cell division -2.37912 2.862424 3.369771 24156 87 873 9 1.030928 0.341867 -0.92439 0 102 0 0 -3.49473 18.44674 81 493|9585| GF|KIF23| Processes 9928|560 KIF20B|KI 34 F14|PDGF CDK6|CO 1021|129 L8A1|FBL 5|2199|23 N2|FN1|P 35|5795|6 GO TPRJ|SFR GO:00108 positive regulation of cell-substrate 422|2597 1 -2.37793 M1 1 0 Biological 19 -2.37793 2.536426 3.2671 24156 120 873 11 1.260023 0.37751 P1|EGFL6| -0.92439 0 39 0 0 -5.93077 3.633448 11 adhesion 5|133584| Processes EGFLAM| 136227|1 COL26A1| 51887|37 CCDC80| 5567 VWC2 ADORA2 A|ADORA 135|136|1 2B|AGTR2 86|1003|1 |CDH5|C 131|1816| GO HRM3|DR GO:00030 1907|190 1 -2.37776 M1 1 0 Biological 19 vascular process in circulatory system -2.37776 2.239199 3.167405 24156 173 873 14 1.603666 0.425147 D5|EDN2| -0.92439 0 115 0 0 -3.30059 4.19244 18 8|3269|33 Processes EDN3|HR 57|3672|5 H1|HTR2 795|6915| B|ITGA1|P 10266 TPRJ|TBX A2R|RAM PDGFRA| GO 5156|527 GO:00105 SERPINE2 1 -2.37114 M1 1 0 Biological 19 negative regulation of platelet activation -2.37114 5.825285 4.074265 24156 19 873 4 0.45819 0.22857 0|7056|17 -0.91957 0 108 0 0 -3.3802 5.825285 44 |THBD|AD Processes 0692 AMTS18 CHRNA1| 1134|375 GO KCNJ2|TN GO:00030 9|7135|71 1 -2.37024 M1 1 0 Biological 19 skeletal muscle contraction -2.37024 3.860945 3.635877 24156 43 873 6 0.687285 0.279617 NI1|TNNI -0.91957 0 61 0 0 -4.53228 18.44674 09 36|7139|7 Processes 2|TNNT2| 140 TNNT3 BRCA1|D 672|1789| GO NMT3B|S GO:00310 4089|508 1 -2.37024 M1 1 0 Biological 19 positive regulation of histone methylation -2.37024 3.860945 3.635877 24156 43 873 6 0.687285 0.279617 MAD4|PA -0.91957 0 184 0 0 -2.53893 6.917526 62 1|8726|55 Processes X7|EED|RI 183 F1 VCAN|H GO 1462|316 GO:00055 MMR|TNF 1 -2.06199 M1 1 0 Molecular 21 hyaluronic acid binding -2.06199 4.812192 3.541801 24156 23 873 4 0.45819 0.22857 1|7130|14 -0.72482 0 239 1 1 -2.06199 4.812192 40 AIP6|HAP Functions 5864 LN3 ALK|BMP 7|CAMK2 238|655|8 A|DAB1|E 15|1600|2 PHB1|EP 047|2048| HB2|GRIN 2902|370 1|ITPKA| GO 6|4208|70 GO:00163 MEF2C|TI 1 -2.3667 M1 1 0 Biological 19 dendrite development -2.3667 2.000248 3.072106 24156 249 873 18 2.061856 0.480948 74|9423|1 -0.91647 0 107 0 0 -3.41128 3.074456 58 AM1|NTN Processes 1141|228 1|IL1RAPL 71|23237| 1|NLGN1| 26037|84 ARC|SIPA 687|8544 1L1|PPP1 2|133584 R9B|KND C1|EGFLA 835|983|6 CASP2|C GO 790|7029| DK1|AUR GO:00724 signal transduction involved in mitotic G1 1 -2.36512 M1 1 0 Biological 19 -2.36512 3.398083 3.509888 24156 57 873 7 0.801833 0.301847 28984|51 KA|TFDP2 -0.91623 0 30 0 0 -6.32789 4.035223 31 DNA damage checkpoint Processes 512|1444 |RGCC|GT 55 SE1|E2F7 835|983|6 CASP2|C GO 790|7029| DK1|AUR GO:19024 intracellular signal transduction involved in 1 -2.36512 M1 1 0 Biological 19 -2.36512 3.398083 3.509888 24156 57 873 7 0.801833 0.301847 28984|51 KA|TFDP2 -0.91623 0 30 0 0 -6.32789 4.035223 00 G1 DNA damage checkpoint Processes 512|1444 |RGCC|GT 55 SE1|E2F7 947|3280| CD34|HES GO 3976|420 1|LIF|MEF GO:00610 cell differentiation involved in kidney 1 -2.36512 M1 1 0 Biological 19 -2.36512 3.398083 3.509888 24156 57 873 7 0.801833 0.301847 8|5420|10 2C|PODX -0.91623 0 118 0 0 -3.28677 7.905744 05 development Processes 413|1073 L|YAP1|SI 6 X2 1894|949 ECT2|KIF2 3|9585|24 3|KIF20B| GO GO:00002 137|2658 KIF4A|CK 1 -2.35868 M1 1 0 Biological 19 mitotic cytokinesis -2.35868 3.074456 3.41348 24156 72 873 8 0.91638 0.322501 -0.91068 0 102 0 0 -3.49473 18.44674 81 6|51203|5 AP2|NUS Processes 4443|551 AP1|ANL 65 N|CEP55 ALK|CDK6 238|1021| |DAB1|GA 1600|261 RT|GRIN1 8|2902|56 |PROX1|T GO 29|7054|9 GO:00215 H|KIF14|T 1 -2.35558 M1 1 0 Biological 19 pallium development -2.35558 2.22633 3.143623 24156 174 873 14 1.603666 0.425147 928|1046 -0.90802 0 78 0 0 -4.09519 2.557741 43 ACC3|LH Processes 0|26468|5 X6|NDE1| 4820|796 MCPH1|P 48|84687| PP1R9B|A 259266 SPM LGALS3|R 3958|910 GN|SFI1|R 4|9814|23 IMBP2|CE GO 504|5512 GO:00109 P192|KNL 1 -2.35512 M1 1 0 Biological 19 negative regulation of phosphatase activity -2.35512 2.660587 3.286199 24156 104 873 10 1.145475 0.360151 5|57082|5 -0.90801 0 199 0 0 -2.40034 2.76701 23 1|PPP4R4| Processes 7718|846 PPP1R9B| 87|84930| MASTL|EL 392617 FN1 88|1908|2 ACTN2|E 048|3759| DN3|EPH 5174|910 B2|KCNJ2 GO 4|10369|2 |PDZK1|R GO:00347 positive regulation of ion transmembrane 1 -2.35265 M1 1 0 Biological 19 -2.35265 2.305842 3.168389 24156 156 873 13 1.489118 0.40992 3237|549 GN|CACN -0.90598 0 45 0 0 -5.5147 9.223368 67 transport Processes 97|57165| G2|ARC|T 126755|1 ESC|GJC2| 96527|72 LRRC38|A 9230 NO6|CCR FAS|CASP 355|835|1 2|ECT2|IT 894|3673| GA2|KCN 3759|421 J2|MAP3K 4|4316|64 1|MMP7| 22|7132|7 SFRP1|TN 520|8111| FRSF1A|X GO GO:00712 8772|102 RCC5|GP 1 -2.3415 M1 1 0 Biological 19 cellular response to abiotic stimulus -2.3415 1.844674 2.991655 24156 330 873 22 2.520046 0.530463 -0.89595 0 83 0 0 -3.90769 3.852799 14 76|10413| R68|FAD Processes 10692|10 D|NET1|Y 991|2706 AP1|RRH| 3|51284|5 SLC38A3| 5031|843 ANKRD1| 29|90427| TLR7|USP 642658 47|HVCN 1|BMF|SC 1894|905 ECT2|PST GO 1|10733|5 PIP1|PLK4 GO:00321 Cellular 4443|548 |ANLN|N 1 -2.05184 M1 1 0 20 cell division site -2.05184 2.73285 3.024903 24156 81 873 8 0.91638 0.322501 -0.71809 0 168 0 0 -2.68133 3.458763 53 Compone 20|55165| DE1|CEP5 nts 83872|84 5|HMCN1 930 |MASTL FAS|CASP 355|835|1 2|ECT2|IT 894|3673| GA2|KCN 3759|421 J2|MAP3K 4|4316|64 1|MMP7| 22|7132|7 SFRP1|TN 520|8111| FRSF1A|X GO GO:01040 8772|102 RCC5|GP 1 -2.3415 M1 1 0 Biological 19 cellular response to environmental stimulus -2.3415 1.844674 2.991655 24156 330 873 22 2.520046 0.530463 -0.89595 0 83 0 0 -3.90769 3.852799 04 76|10413| R68|FAD Processes 10692|10 D|NET1|Y 991|2706 AP1|RRH| 3|51284|5 SLC38A3| 5031|843 ANKRD1| 29|90427| TLR7|USP 642658 47|HVCN 1|BMF|SC BRCA2|M 675|4361| RE11|NEK 4751|507 2|PARN|P 3|5558|75 RIM2|XRC GO 20|8357|9 GO:00322 C5|H3C10 1 -2.33361 M1 1 0 Biological 19 telomere organization -2.33361 2.213608 3.120003 24156 175 873 14 1.603666 0.425147 134|9156| -0.8897 0 85 0 0 -3.87201 3.458763 00 |CCNE2|E Processes 9937|544 XO1|DCL 64|55183| RE1A|XR 80119|80 N1|RIF1|P 169 IF1|CTC1 AGTR2|IT 186|3672| GA1|ITGA 3673|395 2|LGALS3| 8|4208|91 MEF2C|R GO 04|9814|2 GN|SFI1|R GO:00109 1 -2.33361 M1 1 0 Biological 19 regulation of phosphatase activity -2.33361 2.213608 3.120003 24156 175 873 14 1.603666 0.425147 3504|551 IMBP2|CE -0.8897 0 199 0 0 -2.40034 2.76701 21 Processes 25|57082| P192|KNL 57718|84 1|PPP4R4| 687|8493 PPP1R9B| 0|392617 MASTL|EL FN1 GO GO:00061 2618|547 GART|PP 1 -2.33108 M1 1 0 Biological 19 IMP biosynthetic process -2.33108 8.301031 4.471495 24156 10 873 3 0.343643 0.198061 -0.8897 0 135 0 0 -3.06206 13.83505 88 1|10606 AT|PAICS Processes GO GO:00613 cardiac neural crest cell development 655|3280| BMP7|HE 1 -2.33108 M1 1 0 Biological 19 -2.33108 8.301031 4.471495 24156 10 873 3 0.343643 0.198061 -0.8897 0 198 0 0 -2.41795 18.44674 09 involved in outflow tract morphogenesis 5308 S1|PITX2 Processes GO ITGA1|IT 3672|367 GO:00986 Cellular GA2|ITGB 1 -2.04229 M1 1 0 20 protein complex involved in cell adhesion -2.04229 3.84307 3.305532 24156 36 873 5 0.572738 0.255402 3|3690|36 -0.71099 0 186 0 0 -2.51714 11.06804 36 Compone 3|ITGB4|J 91|58494 nts AM2 57165|57 GJC2|GJD R-HSA- Reactome 369|7986 2|TUBAL3 1 -2.04229 M1 1 0 6 Gap junction assembly -2.04229 3.84307 3.305532 24156 36 873 5 0.572738 0.255402 -0.71099 0 241 1 1 -2.04229 3.84307 190861 Gene Sets 1|81027|2 |TUBB1|G 19770 JD4 GO 4155|645 MBP|SH3 GO:00356 maintenance of permeability of blood- 1 -2.33108 M1 1 0 Biological 19 -2.33108 8.301031 4.471495 24156 10 873 3 0.343643 0.198061 6|100506 GL2|OCL -0.8897 0 201 1 1 -2.33108 9.223368 33 brain barrier Processes 658 N ADORA2 135|2890| A|GRIA1| 2902|291 GRIN1|GR GO 3|4208|52 M3|MEF2 GO:00352 1 -2.32557 M1 1 0 Biological 19 synaptic transmission, glutamatergic -2.32557 2.635248 3.251643 24156 105 873 10 1.145475 0.360151 70|22871| C|SERPIN -0.88656 0 202 1 1 -2.32557 4.882959 49 Processes 57616|22 E2|NLGN 2256|729 1|TSHZ3| 230 CDHR3|C CR2 CDH5|CD 1003|100 H7|CDH9| 5|1007|10 CDH10|C 08|1009|1 DH11|CN 266|4361| N3|MRE1 5795|664 1|PTPRJ|S 2|7223|83 NX1|TRP GO GO:00452 57|8727|9 C4|H3C10 1 -2.02583 M1 1 0 Molecular 21 cadherin binding -2.02583 1.755505 2.679946 24156 331 873 21 2.405498 0.518571 -0.69548 0 32 0 0 -6.28754 6.917526 96 133|1060 |CTNNAL Functions 6|26156|2 1|CCNB2| 9091|297 PAICS|RS 66|54443| L1D1|STX 57650|64 BP6|TMO 072|2222 D3|ANLN| 56 CIP2A|CD H23|CDH CDH5|FG 1003|224 F2|VEGFD 7|2277|36 |ITGB3|PD GO 90|5156|5 GO:00708 GFRA|PG 1 -2.02451 M1 1 0 Molecular 21 growth factor receptor binding -2.02451 2.271426 2.857789 24156 134 873 11 1.260023 0.37751 228|5795| -0.69484 0 60 0 0 -4.57507 9.223368 51 F|PTPRJ|S Functions 6642|110 NX1|ESM 82|23768| 1|FLRT2|P 56034 DGFC ACTN1|A 87|88|215 CTN2|F8| 7|2277|23 VEGFD|F R-HSA- Reactome Response to elevated platelet cytosolic 35|3690|5 N1|ITGB3| 1 -2.02451 M1 1 0 6 -2.02451 2.271426 2.857789 24156 134 873 11 1.260023 0.37751 -0.69484 0 81 0 0 -3.97669 6.510612 76005 Gene Sets Ca2+ 175|7057| PECAM1| 7078|101 THBS1|TI 84|94121 MP3|LHF PL2|SYTL DAB1|HE GO 1600|328 GO:00487 S1|LIF|NT 1 -2.3241 M1 1 0 Biological 19 regulation of astrocyte differentiation -2.3241 4.46292 3.735776 24156 31 873 5 0.572738 0.255402 0|3976|49 -0.88656 0 56 0 0 -4.84716 6.385408 10 RK3|SERPI Processes 16|5270 NE2 6491|679 STIL|AUR GO GO:00715 0|55125|7 KA|CEP19 1 -2.3241 M1 1 0 Biological 19 protein localization to centrosome -2.3241 4.46292 3.735776 24156 31 873 5 0.572738 0.255402 -0.88656 0 66 0 0 -4.4085 4.770707 39 9648|121 2|MCPH1| Processes 441 NEDD1 GRIN1|PE GO 2902|517 GO:00140 NK|CXCR 1 -2.3241 M1 1 0 Biological 19 response to isoquinoline alkaloid -2.3241 4.46292 3.735776 24156 31 873 5 0.572738 0.255402 9|7852|87 -0.88656 0 123 0 0 -3.23644 5.764605 72 4|FADD|P Processes 72|84687 PP1R9B DRD5|GRI GO 1816|290 GO:00190 N1|SERPI 1 -2.3241 M1 1 0 Biological 19 reproductive behavior -2.3241 4.46292 3.735776 24156 31 873 5 0.572738 0.255402 2|5270|70 -0.88656 0 123 0 0 -3.23644 5.764605 98 NE2|TH|P Processes 54|84687 PP1R9B GRIN1|PE GO 2902|517 GO:00432 NK|CXCR 1 -2.3241 M1 1 0 Biological 19 response to morphine -2.3241 4.46292 3.735776 24156 31 873 5 0.572738 0.255402 9|7852|87 -0.88656 0 123 0 0 -3.23644 5.764605 78 4|FADD|P Processes 72|84687 PP1R9B ALOX5|BI RC5|CREB 240|332|1 1|DUSP7| 385|1849| FGF2|FN1 2247|233 |LIF|LMNB 5|3976|40 1|MEF2C| 01|4208|4 MMP1|M 312|5600| APK11|PT 5783|609 PN13|RO 5|6935|71 R-HSA- Reactome RA|ZEB1| 1 -2.00053 M1 1 0 6 Signaling by Interleukins -2.00053 1.620592 2.605069 24156 461 873 27 3.092784 0.58593 32|7133|8 -0.67289 0 244 1 1 -2.00053 2.305842 449147 Gene Sets TNFRSF1 357|8767| A|TNFRSF 9180|998 1B|H3C10 7|10454|1 |RIPK2|OS 1141|506 MR|HNR 15|53832| NPDL|TA 84867|65 B1|IL1RA 3604|729 PL1|IL21R 230 |IL20RA|P TPN5|H3 2324|693 FLT4|TCF GO GO:00030 9|22871|5 15|NLGN 1 -2.3241 M1 1 0 Biological 19 respiratory system process -2.3241 4.46292 3.735776 24156 31 873 5 0.572738 0.255402 -0.88656 0 202 0 0 -2.32557 4.882959 16 7616|147 1|TSHZ3| Processes 372 CCBE1 ACTN2|C R-HSA- Reactome 88|815|28 AMK2A|G 1 -1.99519 M1 1 0 6 Long-term potentiation -1.99519 4.611684 3.427756 24156 24 873 4 0.45819 0.22857 -0.67008 0 164 0 0 -2.711 11.06804 9620244 Gene Sets 90|2902 RIA1|GRI N1 MRE11|E GO 4361|915 GO:00045 XO1|DCL 1 -1.99519 M1 1 0 Molecular 21 exodeoxyribonuclease activity -1.99519 4.611684 3.427756 24156 24 873 4 0.45819 0.22857 6|9937|92 -0.67008 0 188 0 0 -2.46134 6.917526 29 RE1A|MG Functions 667 ME1 MRE11|E GO 4361|915 GO:00168 exodeoxyribonuclease activity, producing XO1|DCL 1 -1.99519 M1 1 0 Molecular 21 -1.99519 4.611684 3.427756 24156 24 873 4 0.45819 0.22857 6|9937|92 -0.67008 0 188 0 0 -2.46134 6.917526 95 5'-phosphomonoesters RE1A|MG Functions 667 ME1 ACTN2|C 88|1490|4 CN2|MET| 233|4916| NTRK3|PR 5629|642 OX1|SFRP 2|7456|10 1|WIPF1|P 733|1078 GO LK4|IQGA GO:00514 positive regulation of cytoskeleton 8|11346|2 1 -2.32379 M1 1 0 Biological 19 -2.32379 2.027551 3.04524 24156 232 873 17 1.947308 0.467671 P2|SYNP -0.88656 0 14 0 0 -9.68163 3.166231 95 organization 2843|229 Processes O|PPM1E| 98|25886| LIMCH1|P 28984|55 OC1A|RG 835|8545 CC|CENPJ 9|100506 |CEP295| 658 OCLN 1894|745 ECT2|WIP GO 6|9493|22 F1|KIF23| GO:00308 1 -2.32272 M1 1 0 Biological 19 cortical cytoskeleton organization -2.32272 3.339495 3.454115 24156 58 873 7 0.801833 0.301847 871|2343 NLGN1|R -0.88656 0 102 0 0 -3.49473 18.44674 65 Processes 3|54443|5 HOQ|ANL 7381 N|RHOJ 3832|958 KIF11|KIF GO GO:19909 5|9928|26 20B|KIF14 1 -1.99205 M1 1 0 Molecular 21 ATP-dependent microtubule motor activity -1.99205 3.739203 3.228766 24156 37 873 5 0.572738 0.255402 -0.67008 0 46 0 0 -5.44351 7.281606 39 153|8193 |KIF26A|KI Functions 0 F18A BARD1|B 580|672|4 R-HSA- Reactome RCA1|MR 1 -1.99205 M1 1 0 6 HDR through Single Strand Annealing (SSA) -1.99205 3.739203 3.228766 24156 37 873 5 0.572738 0.255402 361|9156| -0.67008 0 70 0 0 -4.32747 27.6701 5685938 Gene Sets E11|EXO1 80010 |RMI1 AGTR2|C 186|1003| DH5|ITGA GO 3672|367 GO:00353 1|ITGA2| 1 -2.32272 M1 1 0 Biological 19 positive regulation of dephosphorylation -2.32272 3.339495 3.454115 24156 58 873 7 0.801833 0.301847 3|4208|91 -0.88656 0 186 0 0 -2.51714 11.06804 06 MEF2C|R Processes 04|15731 GN|CDCA 3 2 BRCA1|LI 672|3976| GO F|SMAD4| GO:19019 4089|556 1 -2.31979 M1 1 0 Biological 19 positive regulation of protein acetylation -2.31979 3.773196 3.56518 24156 44 873 6 0.687285 0.279617 PRKAA2|P -0.88493 0 184 0 0 -2.53893 6.917526 85 3|10891|8 Processes PARGC1A 5459 |CEP295 186|2324| AGTR2|FL GO GO:00019 3976|420 T4|LIF|ME 1 -2.31979 M1 1 0 Biological 19 blood vessel remodeling -2.31979 3.773196 3.56518 24156 44 873 6 0.687285 0.279617 -0.88493 0 203 1 1 -2.31979 3.773196 74 8|54567|7 F2C|DLL4| Processes 29230 CCR2 ACTL6A|C 86|2491|5 ENPI|RBB 931|2342 GO P7|ITGB3 GO:00430 1|55355|5 1 -2.31355 M1 1 0 Biological 19 ATP-dependent chromatin remodeling -2.31355 2.7981 3.290706 24156 89 873 9 1.030928 0.341867 BP|HJURP -0.87998 0 31 0 0 -6.31644 12.57732 44 5839|570 Processes |CENPN|K 82|91687| NL1|CEN 401541 PL|CENPP 675|1894| BRCA2|EC 6790|949 T2|AURK GO GO:00324 3|9585|99 A|KIF23|KI 1 -2.31355 M1 1 0 Biological 19 regulation of cytokinesis -2.31355 2.7981 3.290706 24156 89 873 9 1.030928 0.341867 -0.87998 0 102 0 0 -3.49473 18.44674 65 28|10733| F20B|KIF1 Processes 56155|14 4|PLK4|TE 4455 X14|E2F7 5629|669 PROX1|SP 2|54567|5 INT1|DLL GO 7165|575 4|GJC2|DI GO:20001 regulation of neural precursor cell 1 -2.31355 M1 1 0 Biological 19 -2.31355 2.7981 3.290706 24156 89 873 9 1.030928 0.341867 40|57650| SP3|CIP2 -0.87998 0 105 0 0 -3.44041 3.074456 77 proliferation Processes 131405|2 A|TRIM71 59266|40 |ASPM|TA 7738 FA1 ACTN2|A GTR2|BAR D1|CD34| 88|186|58 COMT|CR 0|947|131 HBP|EPH 2|1393|20 B2|FN1|G 48|2335|2 PM6B|IN 824|3624| HBA|ITGB 3690|395 3|LGALS3| 8|3976|51 LIF|ENPP1 67|5270|5 |SERPINE 587|5593| GO 2|PRKD1| GO:00510 6422|705 1 -2.30866 M1 1 0 Biological 19 negative regulation of transport -2.30866 1.630651 2.87809 24156 543 873 32 3.665521 0.635992 PRKG2|SF -0.87552 0 204 1 1 -2.30866 2.003265 51 7|7132|71 Processes RP1|THBS 33|11141| 1|TNFRSF 28984|29 1A|TNFRS 091|2996 F1B|IL1RA 9|51715|9 PL1|RGCC 1461|941 |STXBP6| 21|11489 MDFIC|R 9|131450| AB23|PKD 347730|7 CC|SYTL4| 29230 C1QTNF3 |CD200R1 |LRRTM1| R-HSA- Reactome 4060|496 LUM|OG 1 -1.98904 M1 1 0 6 Keratan sulfate degradation -1.98904 6.385408 3.760849 24156 13 873 3 0.343643 0.198061 -0.67008 0 96 0 0 -3.66151 10.37629 2022857 Gene Sets 9|11081 N|KERA CHRNA1| 1134|204 EPHB1|M 7|4208|50 EF2C|PAX 81|7093|9 7|TLL2|M GO 242|1032 GO:00075 SC|KLHL4 1 -2.30617 M1 1 0 Biological 19 skeletal muscle tissue development -2.30617 2.276654 3.117493 24156 158 873 13 1.489118 0.40992 4|27063|3 -0.87346 0 124 0 0 -3.22859 6.58812 19 1|ANKRD Processes 0812|574 1|SOX8|N 86|64091| LN|POPD 93649|64 C2|MYOC 2658 D|SCX BARD1|B 580|675|7 RCA2|CAL 94|947|11 B2|CD34| 34|1490|2 CHRNA1| 103|3690| CCN2|ES 4361|475 RRB|ITGB 1|5073|55 3|MRE11| 58|7520|9 NEK2|PA GO 134|9156| RN|PRIM GO:00602 1 -2.29476 M1 1 0 Biological 19 anatomical structure homeostasis -2.29476 1.709594 2.898638 24156 437 873 27 3.092784 0.58593 9937|104 2|XRCC5| -0.86267 0 85 0 0 -3.87201 3.458763 49 Processes 13|10590| CCNE2|E 53832|54 XO1|DCL 464|5518 RE1A|YAP 3|56890|6 1|SCGN|IL 4072|801 20RA|XR 19|80169| N1|RIF1| 642658|7 MDM1|C 29230 DH23|PIF 1|CTC1|S FAS|BMP 7|CDKN2 B|COMT| 355|655|1 CREB1|CY 030|1312| P24A1|D 1385|159 NMT3B|G 1|1789|29 RIN1|ITG 02|3673|4 A2|MMP7 316|5179| |PENK|PM 5366|556 AIP1|PRK 3|5587|56 AA2|PRK GO 29|6422|6 GO:00316 D1|PROX 1 -2.29452 M1 1 0 Biological 19 response to nutrient levels -2.29452 1.656892 2.877019 24156 501 873 30 3.436426 0.616528 915|7054| -0.86267 0 50 0 0 -5.25088 2.470545 67 1|SFRP1|T Processes 8854|938 BXA2R|T 8|10631|1 H|ALDH1 0891|109 A2|LIPG|P 91|80010| OSTN|PP 81788|14 ARGC1A| 3686|154 SLC38A3| 743|3894 RMI1|NU 00|44073 AK2|SESN 8|652968 3|BMT2|G FRAL|MA P1LC3C|C R-HSA- Reactome 355|8743| FAS|TNFS 1 -1.98904 M1 1 0 6 CASP8 activity is inhibited -1.98904 6.385408 3.760849 24156 13 873 3 0.343643 0.198061 -0.67008 0 141 0 0 -2.97821 18.44674 5218900 Gene Sets 8772 F10|FADD GO 3280|397 HES1|LIF| GO:00722 1 -2.28667 M1 1 0 Biological 19 metanephric nephron tubule development -2.28667 5.534021 3.927869 24156 20 873 4 0.45819 0.22857 6|10413|3 YAP1|SO -0.85652 0 118 0 0 -3.28677 7.905744 34 Processes 0812 X8 GO CENPE|KI GO:19900 Cellular 1062|958 1 -1.98904 M1 1 0 20 mitotic spindle midzone -1.98904 6.385408 3.760849 24156 13 873 3 0.343643 0.198061 F20B|KIF1 -0.67008 0 155 0 0 -2.83885 13.83505 23 Compone 5|81930 8A nts INHBA|S R-HSA- Reactome 3624|408 1 -1.98904 M1 1 0 6 Signaling by Activin -1.98904 6.385408 3.760849 24156 13 873 3 0.343643 0.198061 MAD4|FS -0.67008 0 197 0 0 -2.41795 18.44674 1502540 Gene Sets 9|10468 T GO 947|1385| CD34|CRE GO:00716 positive regulation of transforming growth 1 -2.28667 M1 1 0 Biological 19 -2.28667 5.534021 3.927869 24156 20 873 4 0.45819 0.22857 4060|705 B1|LUM|T -0.85652 0 163 0 0 -2.77297 7.905744 36 factor beta production Processes 7 HBS1 672|899|1 BRCA1|C 003|4089| CNF|CDH 4233|475 5|SMAD4| GO 1|22974|2 MET|NEK GO:00514 negative regulation of cytoskeleton 1 -2.28329 M1 1 0 Biological 19 -2.28329 2.262335 3.092332 24156 159 873 13 1.489118 0.40992 6586|297 2|TPX2|C -0.85457 0 38 0 0 -5.99119 2.543491 94 organization Processes 66|50853| KAP2|TM 56890|57 OD3|VILL| 159|8495 MDM1|TR 2 IM54|CG CDK6|CO 1021|129 L8A1|FBL 5|2199|23 N2|FN1|G 35|2824|5 PM6B|PT 795|6422| PRJ|SFRP GO 7057|972 1|THBS1| GO:00108 1 -2.28244 M1 1 0 Biological 19 regulation of cell-substrate adhesion -2.28244 2.05917 3.020683 24156 215 873 16 1.832761 0.453972 3|10631|2 SEMA3E| -0.85457 0 39 0 0 -5.93077 3.633448 10 Processes 2998|259 POSTN|LI 75|13358 MCH1|EG 4|136227| FL6|EGFL 151887|3 AM|COL2 75567 6A1|CCD C80|VWC 835|983|6 CASP2|C GO 790|7029| DK1|AUR GO:00724 signal transduction involved in mitotic cell 1 -2.28131 M1 1 0 Biological 19 -2.28131 3.282894 3.399549 24156 59 873 7 0.801833 0.301847 28984|51 KA|TFDP2 -0.85457 0 30 0 0 -6.32789 4.035223 13 cycle checkpoint Processes 512|1444 |RGCC|GT 55 SE1|E2F7 835|983|6 CASP2|C GO 790|7029| DK1|AUR GO:19024 signal transduction involved in mitotic DNA 1 -2.28131 M1 1 0 Biological 19 -2.28131 3.282894 3.399549 24156 59 873 7 0.801833 0.301847 28984|51 KA|TFDP2 -0.85457 0 30 0 0 -6.32789 4.035223 02 damage checkpoint Processes 512|1444 |RGCC|GT 55 SE1|E2F7 ACTL6A|B ARD1|BR 86|580|67 CA1|BRC 2|675|218 A2|FANC 7|2188|30 B|FANCF| 15|3838|4 H2AZ1|KP 361|5395| NA2|MRE 7520|915 R-HSA- Reactome 11|PMS2| 1 -1.9844 M1 1 0 6 DNA Repair -1.9844 1.739737 2.636044 24156 334 873 21 2.405498 0.518571 6|9937|51 -0.66643 0 54 0 0 -4.90339 3.029573 73894 Gene Sets XRCC5|EX 514|5518 O1|DCLR 3|55215|6 E1A|DTL| 3967|800 RIF1|FAN 10|91442| CI|CLSPN| 146956|3 RMI1|FAA 53497 P24|EME1 |POLN BARD1|B 580|672|6 RCA1|BR R-HSA- Reactome HDR through Homologous Recombination 75|4361|9 1 -1.98214 M1 1 0 6 -1.98214 2.890906 3.00116 24156 67 873 7 0.801833 0.301847 CA2|MRE -0.66492 0 70 0 0 -4.32747 27.6701 5685942 Gene Sets (HRR) 156|8001 11|EXO1| 0|146956 RMI1|EM 835|983|6 CASP2|C GO 790|7029| DK1|AUR GO:19024 signal transduction involved in mitotic DNA 1 -2.28131 M1 1 0 Biological 19 -2.28131 3.282894 3.399549 24156 59 873 7 0.801833 0.301847 28984|51 KA|TFDP2 -0.85457 0 30 0 0 -6.32789 4.035223 03 integrity checkpoint Processes 512|1444 |RGCC|GT 55 SE1|E2F7 AGTR2|C 186|1393| RHBP|EP GO 2048|108 GO:20002 negative regulation of signaling receptor HB2|PPA 1 -2.28131 M1 1 0 Biological 19 -2.28131 3.282894 3.399549 24156 59 873 7 0.801833 0.301847 91|27123| -0.85457 0 205 1 1 -2.28131 4.19244 72 activity RGC1A|D Processes 117166|1 KK2|WFIK 24857 KN1|WFIK ADORA2 A|ADORA 135|136|1 2B|AGTR2 86|635|81 |BHMT|C 5|947|110 AMK2A|C 3|1312|15 D34|CHA 45|2555|2 T|COMT| 618|2824| CYP1B1|G GO GO:00015 3690|420 ABRA2|G 1 -2.2737 M1 1 0 Biological 19 regulation of neurotransmitter levels -2.2737 1.792711 2.913551 24156 355 873 23 2.634593 0.542066 -0.84759 0 148 0 0 -2.89801 2.548562 05 8|6095|70 ART|GPM Processes 54|9104|2 6B|ITGB3| 2871|260 MEF2C|R 02|29958| ORA|TH|R 55349|55 GN|NLGN 784|2856 1|MOXD1 71 |DMGDH| CHDH|M CTP2|RNF ALK|BMP 7|CRABP2 238|655|1 |DAB1|EP 382|1600| HB2|FN1| 2048|233 GOLGA4| 5|2803|29 GRIN1|IT 02|3673|3 GA2|ITPK 706|4208| A|MEF2C| 4916|497 NTRK3|O 4|5420|55 MG|POD 87|6387|6 XL|PRKD1 422|6498| |CXCL12|S 7074|785 FRP1|SKIL 2|9423|96 GO |TIAM1|C GO:00313 62|9712|9 1 -2.27322 M1 1 0 Biological 19 regulation of cell projection organization -2.27322 1.530849 2.806194 24156 723 873 40 4.581901 0.707671 XCR4|NT -0.84759 0 29 0 0 -6.42481 3.074456 44 723|1032 Processes N1|CEP13 4|11141|2 5|USP6NL 2871|232 |SEMA3E| 16|23237| KLHL41|IL 23433|26 1RAPL1|N 037|2706 LGN1|TB 3|54443|5 C1D1|AR 5835|569 C|RHOQ| 63|85442| SIPA1L1| 151835|1 ANKRD1| 57285|28 ANLN|CE 5016|100 NPJ|RGM 506658 A|KNDC1| CPNE9|PR ACTC1|A GTR2|CC 70|186|14 N2|EDN2| 90|1907|1 EDN3|KC 908|3759| NJ2|KCNJ 3762|409 5|SMAD5| 0|4632|64 GO MYL1|SG GO:00030 45|7054|7 1 -2.27307 M1 1 0 Biological 19 heart process -2.27307 1.88232 2.947389 24156 294 873 20 2.290951 0.50637 CG|TH|TN -0.84759 0 61 0 0 -4.53228 18.44674 15 135|7136| Processes NI1|TNNI 7139|714 2|TNNT2| 0|7852|10 TNNT3|C 369|1041 XCR4|CA 3|10659|6 CNG2|YA 4091 P1|CELF2| POPDC2 2239|491 GPC4|NT GO 6|11141|2 RK3|IL1R GO:00990 1 -2.27085 M1 1 0 Biological 19 presynapse assembly -2.27085 3.689347 3.496525 24156 45 873 6 0.687285 0.279617 2871|262 APL1|NLG -0.8463 0 63 0 0 -4.50244 10.37629 54 Processes 80|34773 N1|IL1RA 0 PL2|LRRT CMKLR1|L 1240|395 GO GALS3|CX GO:00716 8|6387|70 1 -2.27085 M1 1 0 Biological 19 regulation of mononuclear cell migration -2.27085 3.689347 3.496525 24156 45 873 6 0.687285 0.279617 CL12|THB -0.8463 0 152 0 0 -2.8845 27.6701 75 57|19652 Processes S1|ANO6| 7|729230 CCR2 675|1894| BRCA2|EC 6790|949 T2|AURK 3|9585|99 A|KIF23|KI 28|10733| F20B|KIF1 GO GO:00009 24137|26 4|PLK4|KI 1 -2.26895 M1 1 0 Biological 19 cytokinesis -2.26895 2.1763 3.050092 24156 178 873 14 1.603666 0.425147 -0.84531 0 102 0 0 -3.49473 18.44674 10 586|5120 F4A|CKAP Processes 3|54443|5 2|NUSAP 5165|561 1|ANLN|C 55|14445 EP55|TEX 5 14|E2F7 COL4A5| COL5A1| 1287|128 COL9A3| 9|1299|13 CREB1|D 85|1600|2 AB1|EPHB 047|2048| 1|EPHB2| 2902|367 GRIN1|IT 2|3673|36 GA1|ITGA 90|4233|4 2|ITGB3| 902|5600| MET|NRT 6328|638 N|MAPK1 R-HSA- Reactome 7|6456|70 1|SCN3A| 1 -1.96836 M1 1 0 6 Axon guidance -1.96836 1.553937 2.549343 24156 552 873 31 3.550974 0.626348 -0.65367 0 223 0 0 -2.17277 2.325219 422475 Gene Sets 74|7223|7 CXCL12|S 852|9423| H3GL2|TI 9723|241 AM1|TRP 37|55816| C4|CXCR4 56963|64 |NTN1|SE 283|7986 MA3E|KIF 1|81027|1 4A|DOK5| 31873|28 RGMA|AR 4217|284 HGEF28|T 656 UBAL3|TU BB1|COL6 A6|LAMA ADORA2 A|GABRA 135|2555| 2|GABRA 2556|255 3|GABRA GO 7|2565|28 4|GABRG GO:00312 Cellular 90|3690|5 1 -1.96694 M1 1 0 20 leading edge membrane -1.96694 2.067307 2.735976 24156 174 873 13 1.489118 0.40992 1|GRIA1|I -0.65257 0 76 0 0 -4.21719 2.344924 56 Compone 795|7074| TGB3|PTP nts 54997|57 RJ|TIAM1| 608|8468 TESC|JCA 7|152273 D|PPP1R9 B|FGD5 CRABP2|F N1|GOLG 1382|233 A4|NTRK3 5|2803|49 |CXCL12|S 16|6387|6 FRP1|SH3 422|6456| GL2|AUR GO 6790|707 GO:00605 developmental growth involved in KA|TIAM1 1 -2.26868 M1 1 0 Biological 19 -2.26868 2.001667 2.98785 24156 235 873 17 1.947308 0.467671 4|7852|94 -0.84531 0 29 0 0 -6.42481 3.074456 60 morphogenesis |CXCR4|N Processes 23|9723|1 TN1|SEM 0413|106 A3E|YAP1 31|54437| |POSTN|S 151835|1 EMA5B|C 57506 PNE9|RD H10 CALB2|GR GO 794|2890| IA1|GRIN GO:00600 Cellular 2902|228 1 -1.96512 M1 1 0 20 excitatory synapse -1.96512 3.192704 3.064985 24156 52 873 6 0.687285 0.279617 1|NLGN1| -0.65173 0 99 0 0 -3.58101 8.138266 76 Compone 71|34773 LRRTM1|E nts 0|392617 LFN1 1545|406 CYP1B1|L 0|6017|64 UM|RLBP 25|7054|7 1|SFRP5|T 078|9249| H|TIMP3| GO 10692|11 DHRS3|R GO:00076 1 -2.26336 M1 1 0 Biological 19 visual perception -2.26336 2.049637 3.000511 24156 216 873 16 1.832761 0.453972 081|5390 RH|KERA| -0.84234 0 207 1 1 -2.26336 2.049637 01 Processes 4|54437|5 MYO3A|S 4567|573 EMA5B|D 69|64072| LL4|GJD2| 83872|15 CDH23|H 7506 MCN1|RD 6491|679 STIL|AUR GO GO:19055 protein localization to microtubule 0|55125|7 KA|CEP19 1 -2.2632 M1 1 0 Biological 19 -2.2632 4.323454 3.642765 24156 32 873 5 0.572738 0.255402 -0.84234 0 66 0 0 -4.4085 4.770707 08 organizing center 9648|121 2|MCPH1| Processes 441 NEDD1 ALDH1A3 GO 220|1381| |CRABP1| GO:00425 1 -2.2632 M1 1 0 Biological 19 retinoic acid metabolic process -2.2632 4.323454 3.642765 24156 32 873 5 0.572738 0.255402 1382|885 CRABP2| -0.84234 0 131 0 0 -3.08989 10.37629 73 Processes 4|157506 ALDH1A2 |RDH10 ENTPD2| 954|1841| DTYMK|D 1854|261 UT|GART| R-HSA- Reactome 8|5471|62 1 -1.96184 M1 1 0 6 Metabolism of nucleotides -1.96184 2.465653 2.858119 24156 101 873 9 1.030928 0.341867 PPAT|RR -0.64976 0 135 0 0 -3.06206 13.83505 15869 Gene Sets 41|7296|1 M2|TXNR 0606|846 D1|PAICS| 18 NT5C1A BRCA1|C GO 672|983|4 GO:00448 DK1|MRE 1 -2.2632 M1 1 0 Biological 19 mitotic G2/M transition checkpoint -2.2632 4.323454 3.642765 24156 32 873 5 0.572738 0.255402 361|4998| -0.84234 0 208 1 1 -2.2632 4.323454 18 11|ORC1| Processes 63967 CLSPN ADORA2 GO 135|5002| A|SLC22A GO:00156 1 -2.2632 M1 1 0 Biological 19 organic cation transport -2.2632 4.323454 3.642765 24156 32 873 5 0.572738 0.255402 5174|552 18|PDZK1 -0.84234 0 209 1 1 -2.2632 11.06804 95 Processes 44|85413 |SLC47A1| SLC22A1 355|639|1 FAS|PRD 462|1870| M1|VCAN 1907|309 |E2F2|ED Canonical 1 -1.95642 M145 M1 1 0 11 PID P53 DOWNSTREAM PATHWAY -1.95642 2.221687 2.776732 24156 137 873 11 1.260023 0.37751 0|3976|42 N2|HIC1|L -0.64499 0 249 1 1 -1.95642 2.221687 Pathways 33|5366|5 IF|MET|P 395|2898 MAIP1|P 4 MS2|RGC 135|6939| ADORA2 GO GO:00427 7054|800 A|TCF15|T 1 -2.2632 M1 1 0 Biological 19 eating behavior -2.2632 4.323454 3.642765 24156 32 873 5 0.572738 0.255402 -0.84234 0 210 1 1 -2.2632 11.06804 55 10|38940 H|RMI1|G Processes 0 FRAL EPHB2|IT 2048|367 GA1|ITGA 2|3673|36 2|ITGB3|S 90|6328|6 R-HSA- Reactome CN3A|SH 1 -1.95287 M1 1 0 6 L1CAM interactions -1.95287 2.325219 2.806158 24156 119 873 10 1.145475 0.360151 456|2413 -0.64241 0 223 0 0 -2.17277 2.325219 373760 Gene Sets 3GL2|KIF4 7|79861|8 A|TUBAL3 1027|284 |TUBB1|L 217 AMA1 CAMK2A| 815|1600| DAB1|ME 4208|491 F2C|NTRK 6|6387|78 3|CXCL12 GO 52|9423|9 GO:00017 |CXCR4|N 1 -2.26065 M1 1 0 Biological 19 neuron migration -2.26065 2.248196 3.067358 24156 160 873 13 1.489118 0.40992 585|2376 -0.84021 0 211 1 1 -2.26065 2.248196 64 TN1|KIF2 Processes 8|26468|5 0B|FLRT2| 4820|161 LHX6|ND 582|2592 E1|DNAA 66 F4|ASPM CDH5|CD 1003|100 H7|CDH9| 5|1007|10 CDH10|C 08|1009|1 DH11|DA 600|2239| B1|GPC4| 4155|501 MBP|CLD GO 0|5175|11 N11|PEC GO:00987 cell-cell adhesion via plasma-membrane 1 -2.25698 M1 1 0 Biological 19 -2.25698 1.911753 2.944478 24156 275 873 19 2.176403 0.493838 141|2287 AM1|IL1R -0.83737 0 32 0 0 -6.28754 6.917526 42 adhesion molecules Processes 1|51294|5 APL1|NLG 7526|640 N1|PCDH 72|64881| 12|PCDH 83872|91 19|CDH2 624|2222 3|PCDH2 56 0|HMCN1 |NEXN|C 815|1385| CAMK2A| 2890|290 CREB1|GR KEGG 1 -1.94833 hsa05031 M1 1 0 24 Amphetamine addiction -1.94833 2.848393 2.955559 24156 68 873 7 0.801833 0.301847 2|7054|23 IA1|GRIN -0.63851 0 214 0 0 -2.21248 4.19244 Pathway 237|9186 1|TH|ARC| 0 CALML4 BMP7|CA 655|815|2 MK2A|EP 047|2048| HB1|EPH 4233|638 B2|MET|C KEGG 7|7223|78 XCL12|TR 1 -1.94751 hsa04360 M1 1 0 24 Axon guidance -1.94751 2.055493 2.713514 24156 175 873 13 1.489118 0.40992 -0.63802 0 29 0 0 -6.42481 3.074456 Pathway 52|9423|9 PC4|CXC 723|5443 R4|NTN1| 7|84612|9 SEMA3E|S 1653 EMA5B|P ARD6B|B ACTN1|A DORA2A| 87|135|94 CD34|EN 7|954|204 TPD2|EPH 8|2157|28 B2|F8|GP 14|3673|3 5|ITGA2|I 690|5156| TGB3|PD 5270|691 GO GFRA|SER GO:00075 5|7056|70 1 -2.25102 M1 1 0 Biological 19 blood coagulation -2.25102 1.811733 2.90137 24156 336 873 22 2.520046 0.530463 PINE2|TB -0.833 0 108 0 0 -3.3802 5.825285 96 57|7980|8 Processes XA2R|TH 357|2341 BD|THBS1 4|50808|1 |TFPI2|H3 39189|17 C10|ZFP 0692|196 M2|AK3|D 527|6536 GKK|ADA 04 MTS18|A NO6|H3C BMP7|FG 655|2247| F2|HES1|S GO 3280|408 GO:00350 MAD4|SF 1 -2.25049 M1 1 0 Biological 19 somatic stem cell population maintenance -2.25049 2.951478 3.277541 24156 75 873 8 0.91638 0.322501 9|6422|10 -0.833 0 10 0 0 -10.1376 3.952872 19 RP1|YAP1 Processes 413|1073 |SIX2|FOX 6|27022 D3 186|2247| AGTR2|F GO 3280|397 GF2|HES1 GO:00720 1 -2.25049 M1 1 0 Biological 19 nephron epithelium morphogenesis -2.25049 2.951478 3.277541 24156 75 873 8 0.91638 0.322501 6|4089|52 |LIF|SMA -0.833 0 10 0 0 -10.1376 3.952872 88 Processes 28|10736| D4|PGF|SI 30812 X2|SOX8 BMP7|IN 655|3624| HBA|ITGA GO 3673|369 GO:00017 2|ITGB3|I 1 -2.25049 M1 1 0 Biological 19 mesoderm formation -2.25049 2.951478 3.277541 24156 75 873 8 0.91638 0.322501 0|3691|72 -0.833 0 146 0 0 -2.93585 3.952872 07 TGB4|TX Processes 96|10736| NRD1|SIX 642658 2|SCX FZD2|SFR 2535|642 P1|STIL|S 2|6491|66 GO PINT1|LM GO:00018 92|8543|9 1 -2.25011 M1 1 0 Biological 19 neural tube closure -2.25011 2.736604 3.213806 24156 91 873 9 1.030928 0.341867 O4|KIF20 -0.833 0 64 0 0 -4.46525 3.120688 43 585|5761 Processes B|SHROO 9|131405| M3|TRIM 144165 71|PRICKL 639|655|2 PRDM1|B 103|3280| MP7|ESR GO GO:00018 3976|669 RB|HES1|L 1 -2.25011 M1 1 0 Biological 19 embryonic placenta development -2.25011 2.736604 3.213806 24156 91 873 9 1.030928 0.341867 -0.833 0 149 0 0 -2.89663 7.905744 92 2|10733|5 IF|SPINT1| Processes 1294|144 PLK4|PCD 455 H12|E2F7 1870|691 E2F2|TBX 5|7057|70 A2R|THBS 58|7075|9 1|THBS2| 723|1051 TIE1|SEM GO GO:00165 6|23213|2 A3E|FBLN 1 -2.24781 M1 1 0 Biological 19 negative regulation of angiogenesis -2.24781 2.164142 3.027097 24156 179 873 14 1.603666 0.425147 -0.83151 0 15 0 0 -9.08083 2.73285 25 8984|545 5|SULF1|R Processes 67|64102| GCC|DLL4 79812|64 |TNMD|M 1700|729 MRN2|EC 230 SCR|CCR2 BMP7|CD 655|1003| H5|CDKN 1030|328 2B|HES1|I GO positive regulation of transmembrane GO:00901 0|3624|40 NHBA|SM 1 -2.23942 M1 1 0 Biological 19 receptor protein serine/threonine kinase -2.23942 2.562047 3.150341 24156 108 873 10 1.145475 0.360151 -0.82724 0 136 0 0 -3.0513 3.816566 00 89|7057|7 AD4|THB Processes signaling pathway 272|2321 S1|TTK|SU 3|93649 LF1|MYO CD CREB1|M 1385|420 EF2C|PLA Canonical PID P38 ALPHA BETA DOWNSTREAM 1 -1.94359 M229 M1 1 0 11 -1.94359 3.640803 3.154629 24156 38 873 5 0.572738 0.255402 8|5321|56 2G4A|MA -0.63699 0 255 1 1 -1.94359 11.06804 Pathways PATHWAY 00|10891 PK11|PPA RGC1A XIAP|BIRC 5|C4A|CD 331|332|7 KN2B|CO 20|1030|1 L7A1|LGA 294|3958| LS3|SERPI 5270|669 NE2|SPIN 2|7078|70 T1|TIMP3| 79|7980|9 TIMP4|TF GO 232|1078 GO:00048 PI2|PTTG 1 -1.93657 M1 1 0 Molecular 21 enzyme inhibitor activity -1.93657 1.674769 2.567255 24156 380 873 23 2.634593 0.542066 8|51129|5 -0.6303 0 116 0 0 -3.2998 2.23146 57 1|IQGAP2 Functions 4997|794 |ANGPTL 44|80119| 4|TESC|BI 80760|84 RC7|PIF1|I 687|1171 TIH5|PPP 66|12485 1R9B|WFI 7|140902| KKN1|WFI 392617 KKN2|R3 HDML|EL MMP1|M 4312|431 MP7|TLL2 6|7093|95 |ADAMTS GO GO:00042 08|11174| 3|ADAMT 1 -1.93542 M1 1 0 Molecular 21 metalloendopeptidase activity -1.93542 2.44148 2.82492 24156 102 873 9 1.030928 0.341867 -0.62979 0 88 0 0 -3.79065 3.532354 22 57486|64 S6|NLN|M Functions 066|7914 MP27|M 8|170692 MP28|AD AMTS18 BRCA1|D 672|1789| NMT3B|LI 3976|408 F|SMAD4| GO GO:19052 positive regulation of chromatin 9|5081|55 PAX7|PRK 1 -2.23942 M1 1 0 Biological 19 -2.23942 2.562047 3.150341 24156 108 873 10 1.145475 0.360151 -0.82724 0 184 0 0 -2.53893 6.917526 69 organization 87|8726|1 D1|EED|P Processes 0891|551 PARGC1A 83|55196 |RIF1|RES F1 BRCA1|C 672|983|2 DK1|FAN 187|2247| CB|FGF2| 4361|475 MRE11|N 1|5073|75 EK2|PAR GO 20|8317|1 GO:00510 positive regulation of DNA metabolic N|XRCC5| 1 -2.23265 M1 1 0 Biological 19 -2.23265 1.984775 2.950061 24156 237 873 17 1.947308 0.467671 0891|289 -0.82129 0 85 0 0 -3.87201 3.458763 54 process CDC7|PP Processes 84|55183| ARGC1A| 55196|79 RGCC|RIF 075|8016 1|RESF1|D 9|83933|1 SCC1|CTC 44455 1|HDAC1 ACTN2|C RHBP|ED 88|1393|1 N3|STOM 908|2040| |EPHB2|F 2048|227 HL1|GRIA 3|2890|29 1|GRIN1| 02|3739|3 KCNA4|K 759|3762| CNJ2|KC 4208|516 NJ5|MEF2 7|5174|63 C|ENPP1| 28|7057|9 PDZK1|SC 104|9312| GO N3A|THB GO:00347 10369|10 1 -2.22736 M1 1 0 Biological 19 regulation of transmembrane transport -2.22736 1.596352 2.795009 24156 572 873 33 3.780069 0.645469 S1|RGN|K -0.81641 0 45 0 0 -5.5147 9.223368 62 891|2287 Processes CNB2|CA 1|23237|2 CNG2|PP 3433|271 ARGC1A| 33|54997| NLGN1|A 57165|81 RC|RHOQ 033|8432 |KCNH5|T 9|117531| ESC|GJC2| 126755|1 KCNH6|H 96527|72 VCN1|TM 9230|100 C1|LRRC3 506658 8|ANO6|C CR2|OCL BARD1|B 580|672|3 RCA1|HIC 090|4361| 1|MRE11| 5366|556 PMAIP1|P GO 3|5600|59 RKAA2|M GO:19017 regulation of signal transduction by p53 1 -2.22686 M1 1 0 Biological 19 -2.22686 2.152119 3.004253 24156 180 873 14 1.603666 0.425147 31|6790|9 APK11|RB -0.81632 0 101 0 0 -3.49696 2.706858 96 class mediator Processes 156|2297 BP7|AURK 4|27063|5 A|EXO1|T 5003|800 PX2|ANK 10 RD1|PAK1 IP1|RMI1 ADORA2 B|CHRM3 |CCN2|ED 136|1131| N2|ITGA2 1490|190 |KCNJ2|S 7|3673|37 MAD4|TA 59|4089|6 CR1|TBXA GO 869|6915| GO:00902 2R|TNFRS 1 -2.22621 M1 1 0 Biological 19 regulation of muscle system process -2.22621 1.937984 2.927273 24156 257 873 18 2.061856 0.480948 7132|713 -0.81608 0 61 0 0 -4.53228 18.44674 57 F1A|TNFR Processes 3|7135|71 SF1B|TNN 36|7139|7 I1|TNNI2| 140|9312| TNNT2|T 10891|93 NNT3|KC 649 NB2|PPA RGC1A|M YOCD FAS|DUSP 7|MECO 355|1849| M|FGF2| 2122|224 MEF2C|M 7|4208|42 AP3K1|NF 14|4772|5 ATC1|PD 156|5321| GFRA|PLA KEGG 1 -1.93203 hsa04010 M1 1 0 24 MAPK signaling pathway -1.93203 1.844674 2.625682 24156 255 873 17 1.947308 0.467671 5600|713 2G4A|MA -0.62874 0 255 0 0 -1.94359 11.06804 Pathway 2|10125|1 PK11|TNF 0369|104 RSF1A|RA 54|22800| SGRP1|C 25780|84 ACNG2|T 867 AB1|RRAS 2|RASGRP 3|PTPN5 ADORA2 135|794|1 GO A|CALB2| GO:19002 regulation of long-term synaptic 385|2048| 1 -2.22335 M1 1 0 Biological 19 -2.22335 3.609144 3.429806 24156 46 873 6 0.687285 0.279617 CREB1|EP -0.81443 0 49 0 0 -5.27843 3.609144 71 potentiation 10590|23 Processes HB2|SCG 237 N|ARC ACTC1|A 70|88|186 CTN2|AG GO |983|4089 TR2|CDK1 GO:00550 1 -2.21917 M1 1 0 Biological 19 cardiac cell development -2.21917 2.706858 3.176132 24156 92 873 9 1.030928 0.341867 |5156|562 |SMAD4|P -0.8139 0 13 0 0 -9.83559 6.28866 06 Processes 9|10529|5 DGFRA|P 7538 ROX1|NE BL|ALPK3 FZD2|SFR 2535|642 P1|STIL|S 2|6491|66 GO PINT1|LM GO:00606 92|8543|9 1 -2.21917 M1 1 0 Biological 19 tube closure -2.21917 2.706858 3.176132 24156 92 873 9 1.030928 0.341867 O4|KIF20 -0.8139 0 64 0 0 -4.46525 3.120688 06 585|5761 Processes B|SHROO 9|131405| M3|TRIM 144165 71|PRICKL E2F2|MC 1870|417 M6|ORC1 5|4998|49 R-HSA- Reactome |ORC2|PR 1 -1.93106 M1 1 0 6 DNA Replication Pre-Initiation -1.93106 2.604245 2.868958 24156 85 873 8 0.91638 0.322501 99|5558|8 -0.6283 0 20 0 0 -7.69554 7.546392 69002 Gene Sets IM2|CDC 317|8318| 7|CDC45| 55388 MCM10 BMP7|FB 655|2201| N2|GPM6 2824|409 GO B|SMAD5| GO:00457 0|4208|55 1 -2.21917 M1 1 0 Biological 19 positive regulation of ossification -2.21917 2.706858 3.176132 24156 92 873 9 1.030928 0.341867 MEF2C|P -0.8139 0 65 0 0 -4.41834 4.966429 78 87|91461| Processes RKD1|PK 116039|1 DCC|OSR 96527 2|ANO6 BRCA2|M 675|4361| RE11|NEK 4751|507 2|PARN|P 3|5558|75 GO RIM2|XRC GO:00007 20|9134|9 1 -2.21607 M1 1 0 Biological 19 telomere maintenance -2.21607 2.22044 3.017963 24156 162 873 13 1.489118 0.40992 C5|CCNE -0.8139 0 85 0 0 -3.87201 3.458763 23 156|9937| Processes 2|EXO1|D 54464|55 CLRE1A|X 183|8011 RN1|RIF1| 9|80169 PIF1|CTC CDH5|CD 1003|100 H7|CDH9| 5|1007|10 CDH10|C 08|1009|1 DH11|EC GO 894|5010| GO:00452 T2|CLDN1 1 -2.21607 M1 1 0 Biological 19 cell-cell junction organization -2.21607 2.22044 3.017963 24156 162 873 13 1.489118 0.40992 5175|102 -0.8139 0 132 0 0 -3.08964 3.175258 16 1|PECAM Processes 66|64072| 1|RAMP2| 84612|22 CDH23|P 2256|100 ARD6B|C 506658 DHR3|OC PRDM1|F 639|2535| ZD2|HES1 GO 3280|405 GO:00032 |LTBP1|S 1 -2.2158 M1 1 0 Biological 19 ventricular septum development -2.2158 2.912642 3.233728 24156 76 873 8 0.91638 0.322501 2|4089|56 -0.8139 0 75 0 0 -4.23321 3.816566 81 MAD4|PR Processes 29|8543|2 OX1|LMO 3414 4|ZFPM2 CENPI|RB 2491|593 BP7|CHAF 1|8208|83 1B|H3C10 57|23421| |ITGB3BP| GO 55355|55 GO:00063 HJURP|M 1 -2.21248 M1 1 0 Biological 19 nucleosome assembly -2.21248 2.305842 3.043329 24156 144 873 12 1.37457 0.394068 506|5583 -0.8139 0 31 0 0 -6.31644 12.57732 34 ACROH2 Processes 9|57082|9 A2|CENP 1687|401 N|KNL1|C 541|6536 ENPL|CE 04 NPP|H3C COMT|CR 1312|138 EB1|DRD5 5|1816|20 |EPHB2|G 48|2902|3 GO RIN1|HRH GO:00076 269|4885| 1 -2.21248 M1 1 0 Biological 19 learning -2.21248 2.305842 3.043329 24156 144 873 12 1.37457 0.394068 1|NPTX2| -0.8139 0 214 1 1 -2.21248 4.19244 12 7054|113 Processes TH|SYNP 46|23237| O|ARC|PP 84687|16 P1R9B|LR 4312 RN4 VCAN|GP 1462|223 C4|LUM| 9|4060|49 OGN|UG GO 69|7358|9 GO:00060 DH|HS2S 1 -2.21151 M1 1 0 Biological 19 glycosaminoglycan biosynthetic process -2.21151 2.538542 3.117333 24156 109 873 10 1.145475 0.360151 653|1108 -0.8139 0 96 0 0 -3.66151 10.37629 24 T1|KERA| Processes 1|51363|5 CHST15|C 5790|930 SGALNAC 10 T1|B3GNT GO 635|1312| BHMT|CO GO:00421 1 -2.20732 M1 1 0 Biological 19 neurotransmitter catabolic process -2.20732 5.270496 3.791015 24156 21 873 4 0.45819 0.22857 29958|55 MT|DMG -0.8139 0 134 0 0 -3.06206 27.6701 35 Processes 349 DH|CHD GO 2103|328 ESRRB|HE GO:20007 negative regulation of stem cell 1 -2.20732 M1 1 0 Biological 19 -2.20732 5.270496 3.791015 24156 21 873 4 0.45819 0.22857 0|10413|1 S1|YAP1| -0.8139 0 216 1 1 -2.20732 5.270496 37 differentiation Processes 44165 PRICKLE1 GO GO:00308 7139|714 TNNT2|T 1 -1.91611 M1 1 0 Molecular 21 calcium-dependent ATPase activity -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 61 0 0 -4.53228 18.44674 99 0 NNT3 Functions GO GO:00310 7139|714 TNNT2|T 1 -1.91611 M1 1 0 Molecular 21 troponin I binding -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 61 0 0 -4.53228 18.44674 13 0 NNT3 Functions CORUM:2 BARD1|B 1 -1.91611 M1 1 0 CORUM 33 BARD1-BRCA1-CSTF complex -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 580|672 -0.62558 0 70 0 0 -4.32747 27.6701 211 RCA1 CORUM:5 BRCA1|BR 1 -1.91611 M1 1 0 CORUM 33 BRCC complex -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 672|675 -0.62558 0 70 0 0 -4.32747 27.6701 400 CA2 ADORA2 B|ALK|CD 136|238|9 K1|CCN2| 83|1490|1 DUSP7|E 849|1908| DN3|FGF 2247|232 2|FLT4|HT 4|3357|36 R2B|ITGA 72|3976|4 1|LIF|MAP 214|4916| 3K1|NTRK 5156|560 3|PDGFR 0|5795|70 A|MAPK1 GO GO:00434 57|7074|7 1|PTPRJ|T 1 -2.20617 M1 1 0 Biological 19 positive regulation of MAPK cascade -2.20617 1.604064 2.780039 24156 552 873 32 3.665521 0.635992 -0.8139 0 18 0 0 -7.89792 2.69514 10 852|8325| HBS1|TIA Processes 8767|101 M1|CXCR 25|10454| 4|FZD8|RI 29969|55 PK2|RASG 816|5603 RP1|TAB1 4|57608|7 |MDFIC|D 9444|152 OK5|PDG 110|2850 FC|JCAD| 16|38812 BIRC7|NE 1|389400 K10|ALKA L2|TNFAI P8L3|GFR 983|4751| CDK1|NE 5116|865 K2|PCNT| 5|9662|98 DYNLL1|C 14|10733| EP135|SFI GO GO:00224 54820|55 1|PLK4|N 1 -2.20612 M1 1 0 Biological 19 membrane docking -2.20612 2.140229 2.981558 24156 181 873 14 1.603666 0.425147 -0.8139 0 12 0 0 -10.0997 6.06468 06 125|5583 DE1|CEP1 Processes 5|79441|8 92|CENPJ| 0184|121 HAUS3|C 441|3472 EP290|NE 40 DD1|KIF2 GO GO:00381 3690|369 ITGB3|ITG 1 -1.91611 M1 1 0 Molecular 21 neuregulin binding -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 111 0 0 -3.35124 18.44674 32 1 B4 Functions 1870|691 E2F2|TBX 5|7057|70 A2R|THBS 58|7075|9 1|THBS2| 723|1051 TIE1|SEM GO GO:20001 negative regulation of blood vessel 6|23213|2 A3E|FBLN 1 -2.20612 M1 1 0 Biological 19 -2.20612 2.140229 2.981558 24156 181 873 14 1.603666 0.425147 -0.8139 0 15 0 0 -9.08083 2.73285 81 morphogenesis 8984|545 5|SULF1|R Processes 67|64102| GCC|DLL4 79812|64 |TNMD|M 1700|729 MRN2|EC 230 SCR|CCR2 GO TNFRSF1 GO:00431 7132|713 1 -1.91611 M1 1 0 Molecular 21 tumor necrosis factor binding -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 A|TNFRSF -0.62558 0 113 0 0 -3.34087 13.83505 20 3 Functions 1B CORUM:1 ORC 1-5 complex (origin recognition 1-5 4998|499 ORC1|OR 1 -1.91611 M1 1 0 CORUM 33 -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 138 0 0 -3.01725 11.06804 038 complex) 9 C2 R-HSA- Reactome FAS|FAD 1 -1.91611 M1 1 0 6 FasL/ CD95L signaling -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 355|8772 -0.62558 0 141 0 0 -2.97821 18.44674 75157 Gene Sets D CORUM:1 5931|872 RBBP7|EE 1 -1.91611 M1 1 0 CORUM 33 Polycomb repressive complex 2 (PRC 2) -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 142 0 0 -2.96836 11.06804 05 6 D CORUM:7 3090|872 1 -1.91611 M1 1 0 CORUM 33 HIC1-PCL3L-PCR2 complex -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 HIC1|EED -0.62558 0 142 0 0 -2.96836 11.06804 304 6 AGTR2|C ALB2|CD H5|CMKL 186|794|1 R1|SLC31 003|1240| A1|CP|DR 1317|135 D5|EDN2| 6|1816|19 EDN3|FG 07|1908|2 F2|FTL|GP 247|2512| R17|LPAR 2840|284 4|GRIA1| 6|2890|29 GRIN1|HP 02|3263|3 X|HTR2B| 357|3759| KCNJ2|S GO 4089|515 GO:00068 MAD4|PD 1 -2.20534 M1 1 0 Biological 19 cellular ion homeostasis -2.20534 1.534984 2.750498 24156 685 873 38 4.352806 0.690579 6|5167|63 -0.8139 0 94 0 0 -3.67332 2.548562 73 GFRA|EN Processes 41|6387|6 PP1|SCO1 869|6915| |CXCL12| 7223|785 TACR1|TB 2|9104|94 XA2R|TRP 97|10590| C4|CXCR4 11346|22 |RGN|SLC 821|3000 4A7|SCG 1|51554|5 N|SYNPO| 5013|640 RASA3|ER 72|83959| O1A|ACK 729230 R4|MCUB| CDH23|SL C4A11|CC SERPINE2 GO 5270|562 GO:00216 |PROX1|R 1 -2.20472 M1 1 0 Biological 19 cerebellar cortex morphogenesis -2.20472 4.19244 3.553491 24156 33 873 5 0.572738 0.255402 9|6095|99 -0.8139 0 92 0 0 -3.73382 12.29782 96 ORA|KIF1 Processes 28|85442 4|KNDC1 CHRM3|E GO 1131|190 GO:00459 positive regulation of smooth muscle DN2|ITGA 1 -2.20472 M1 1 0 Biological 19 -2.20472 4.19244 3.553491 24156 33 873 5 0.572738 0.255402 7|3673|69 -0.8139 0 115 0 0 -3.30059 4.19244 87 contraction 2|TBXA2R Processes 15|93649 |MYOCD GO GO:00059 Cellular calcium- and calmodulin-dependent 815|5717 CAMK2A| 1 -1.91611 M1 1 0 20 -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 164 0 0 -2.711 11.06804 54 Compone protein kinase complex 2 CAMK1G nts GO GO:00482 mitogen-activated protein kinase p38 4772|104 NFATC1|T 1 -1.91611 M1 1 0 Molecular 21 -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 178 0 0 -2.59562 18.44674 73 binding 54 AB1 Functions GO GO:00056 Cellular 4001|848 LMNB1|L 1 -1.91611 M1 1 0 20 lamin filament -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 181 0 0 -2.59355 11.06804 38 Compone 23 MNB2 nts GO GO:00986 collagen binding involved in cell-matrix 3672|367 ITGA1|IT 1 -1.91611 M1 1 0 Molecular 21 -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 186 0 0 -2.51714 11.06804 39 adhesion 3 GA2 Functions R-HSA- Reactome 4233|647 MET|TNS 1 -1.91611 M1 1 0 6 MET interacts with TNS proteins -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 193 0 0 -2.41795 18.44674 8875513 Gene Sets 59 3 GO GO:00431 CD34|SM 1 -1.91611 M1 1 0 Molecular 21 sulfate binding -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 947|4089 -0.62558 0 197 0 0 -2.41795 18.44674 99 AD4 Functions GO 186|3280| AGTR2|H GO:00033 1 -2.20472 M1 1 0 Biological 19 metanephros morphogenesis -2.20472 4.19244 3.553491 24156 33 873 5 0.572738 0.255402 3976|107 ES1|LIF|SI -0.8139 0 118 0 0 -3.28677 7.905744 38 Processes 36|30812 X2|SOX8 ADORA2 GO 135|1816| GO:00019 A|DRD5|G 1 -2.20472 M1 1 0 Biological 19 response to amphetamine -2.20472 4.19244 3.553491 24156 33 873 5 0.572738 0.255402 2902|705 -0.8139 0 123 0 0 -3.23644 5.764605 75 RIN1|TH| Processes 4|84687 PPP1R9B 2840|284 GPR17|LP GO GO:00350 positive regulation of Rho protein signal 6|10276|5 AR4|NET1 1 -2.20472 M1 1 0 Biological 19 -2.20472 4.19244 3.553491 24156 33 873 5 0.572738 0.255402 -0.8139 0 145 0 0 -2.94443 4.19244 25 transduction 0650|157 |ARHGEF Processes 285 3|PRAG1 R-HSA- Reactome 1385|420 CREB1|M 1 -1.91611 M1 1 0 6 MECP2 regulates transcription factors -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 255 0 0 -1.94359 11.06804 9022707 Gene Sets 8 EF2C

R-HSA- Reactome 10125|25 RASGRP1| 1 -1.91611 M1 1 0 6 Activation of RAS in B cells -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 257 1 1 -1.91611 11.06804 1169092 Gene Sets 780 RASGRP3 CRABP2| 1382|885 GO ALDH1A2 GO:00351 4|116039| 1 -2.20472 M1 1 0 Biological 19 embryonic forelimb morphogenesis -2.20472 4.19244 3.553491 24156 33 873 5 0.572738 0.255402 |OSR2|RD -0.8139 0 176 0 0 -2.63058 4.19244 15 157506|3 Processes H10|RSP 40419 O2 GO GO:00513 ACTN2|M 1 -1.91611 M1 1 0 Molecular 21 FATZ binding -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 88|91977 -0.62558 0 259 1 1 -1.91611 11.06804 73 YOZ3 Functions R-HSA- Reactome Activation of NOXA and translocation to 5366|702 PMAIP1|T 1 -1.91611 M1 1 0 6 -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 260 1 1 -1.91611 11.06804 111448 Gene Sets mitochondria 9 FDP2 DNMT3B| 1789|417 MCM6|M 5|4361|71 RE11|TOP 53|7520|9 2A|XRCC5 156|9937| |EXO1|DC GO GO:01400 54108|54 LRE1A|CH 1 -1.91252 M1 1 0 Molecular 21 catalytic activity, acting on DNA -1.91252 1.921535 2.634315 24156 216 873 15 1.718213 0.439813 -0.62231 0 261 1 1 -1.91252 4.882959 97 821|5523 RAC1|ERC Functions 7|79075|8 C6L|VRTN 0119|926 |DSCC1|PI 67|25439 F1|MGME 4|353497 1|MCM9| POLN BRCA1|LI GO 672|3976| GO:20007 positive regulation of peptidyl-lysine F|SMAD4| 1 -2.20472 M1 1 0 Biological 19 -2.20472 4.19244 3.553491 24156 33 873 5 0.572738 0.255402 4089|556 -0.8139 0 184 0 0 -2.53893 6.917526 58 acetylation PRKAA2|P Processes 3|10891 PARGC1A 2890|290 GRIA1|GR GO GO:00076 2|23237|1 IN1|ARC| 1 -2.20472 M1 1 0 Biological 19 long-term memory -2.20472 4.19244 3.553491 24156 33 873 5 0.572738 0.255402 -0.8139 0 214 0 0 -2.21248 4.19244 16 39411|16 PTCHD1|L Processes 4312 RRN4 CHRNA1| GABRA2| 1134|255 GABRA3| 5|2556|25 GABRA4| 57|2565|2 GABRG1| 890|2902| GRIA1|GR 3739|375 GO IN1|KCNA 9|3762|63 GO:00347 Cellular 4|KCNJ2| 1 -1.90425 M1 1 0 20 ion channel complex -1.90425 1.764201 2.570337 24156 298 873 19 2.176403 0.493838 28|7223|9 -0.61496 0 97 0 0 -3.64921 2.294594 02 Compone KCNJ5|SC 312|1036 nts N3A|TRP 9|22871|5 C4|KCNB 5013|126 2|CACNG 755|1965 2|NLGN1| 27|37556 MCUB|LR 7 RC38|AN O6|VWC2 GRIA1|GR 2890|290 IN1|NTRK 2|4916|11 3|IL1RAPL R-HSA- Reactome 141|2287 1 -1.90219 M1 1 0 6 Protein-protein interactions at synapses -1.90219 2.573963 2.831372 24156 86 873 8 0.91638 0.322501 1|NLGN1| -0.61383 0 63 0 0 -4.50244 10.37629 6794362 Gene Sets 1|26037|2 SIPA1L1|I 6280|347 L1RAPL2| 730 LRRTM1 GO MCM6|C GO:00007 double-strand break repair via break- 4175|831 1 -2.20452 M1 1 0 Biological 19 -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 DC7|CDC -0.8139 0 20 0 0 -7.69554 7.546392 27 induced replication 7|8318 Processes 45 GO GO:19001 extracellular regulation of signal 2200|220 FBN1|FBN 1 -2.20452 M1 1 0 Biological 19 -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 -0.8139 0 24 0 0 -7.35548 20.75258 15 transduction 1|4052 2|LTBP1 Processes GO GO:19001 extracellular negative regulation of signal 2200|220 FBN1|FBN 1 -2.20452 M1 1 0 Biological 19 -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 -0.8139 0 24 0 0 -7.35548 20.75258 16 transduction 1|4052 2|LTBP1 Processes GO EPHB1|TL GO:00486 negative regulation of skeletal muscle 2047|709 1 -2.20452 M1 1 0 Biological 19 -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 L2|MYOC -0.8139 0 72 0 0 -4.32747 27.6701 42 tissue development 3|93649 Processes D GO 11104|55 KATNA1| GO:00510 1 -2.20452 M1 1 0 Biological 19 microtubule severing -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 137|4017 FIGN|FIG -0.8139 0 175 0 0 -2.63853 10.37629 13 Processes 20 NL2 GO 1545|573 CYP1B1|R GO:00612 retina vasculature morphogenesis in 1 -2.20452 M1 1 0 Biological 19 -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 81|28421 HOJ|LAM -0.8139 0 189 0 0 -2.46134 9.223368 99 camera-type eye Processes 7 A1 GO FANCB|F GO:00432 Cellular 2187|218 1 -1.89598 M1 1 0 20 Fanconi anaemia nuclear complex -1.89598 5.929308 3.572354 24156 14 873 3 0.343643 0.198061 ANCF|FA -0.61098 0 44 0 0 -5.52611 9.223368 40 Compone 8|91442 AP24 nts GO 240|8767| ALOX5|RI GO:00706 1 -2.20452 M1 1 0 Biological 19 response to interleukin-18 -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 10050665 PK2|OCL -0.8139 0 201 0 0 -2.33108 9.223368 73 Processes 8 N GO EPHB1|EP GO:00050 2047|204 1 -1.89598 M1 1 0 Molecular 21 transmembrane-ephrin receptor activity -1.89598 5.929308 3.572354 24156 14 873 3 0.343643 0.198061 HB2|EPH -0.61098 0 126 0 0 -3.20893 9.223368 05 8|284656 Functions A10 GO GO:00458 negative regulation of meiotic nuclear 3976|727 LIF|TTK|T 1 -2.20452 M1 1 0 Biological 19 -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 -0.8139 0 217 1 1 -2.20452 9.223368 35 division 2|9319 RIP13 Processes GO GO:19030 2200|910 FBN1|RG 1 -2.20452 M1 1 0 Biological 19 negative regulation of bone development -2.20452 7.546392 4.205096 24156 11 873 3 0.343643 0.198061 -0.8139 0 218 1 1 -2.20452 7.546392 11 4|359845 N|RFLNB Processes 1462|223 VCAN|GP GO 9|2247|31 C4|FGF2| GO:00060 1 -2.20137 M1 1 0 Biological 19 glycosaminoglycan catabolic process -2.20137 3.175258 3.293846 24156 61 873 7 0.801833 0.301847 61|4060|4 HMMR|L -0.81153 0 96 0 0 -3.66151 10.37629 27 Processes 969|1108 UM|OGN| 1 KERA CDH5|EC 1003|189 T2|CLDN1 GO 4|5010|51 GO:01201 1|PECAM 1 -2.20137 M1 1 0 Biological 19 tight junction assembly -2.20137 3.175258 3.293846 24156 61 873 7 0.801833 0.301847 75|10266| -0.81153 0 132 0 0 -3.08964 3.175258 92 1|RAMP2| Processes 84612|10 PARD6B| 0506658 OCLN ACTC1|A CTN2|CA 70|88|794 LB2|EPHB |2047|369 1|ITGB3|P 0|5156|51 GO DGFRA|P 74|5420|9 GO:00988 Cellular DZK1|PO 1 -1.89562 M1 1 0 20 actin-based cell projection -1.89562 1.91268 2.615089 24156 217 873 15 1.718213 0.439813 497|1078 -0.61094 0 264 1 1 -1.89562 4.611684 58 Compone DXL|SLC4 8|22871|5 nts A7|IQGAP 3904|640 2|NLGN1| 72|84687| MYO3A|C 117531 DH23|PP P1R9B|T EPHB2|FG 2048|224 F2|GPR17 7|2840|28 |LPAR4|M 46|4233|5 ET|PECA 175|5587| M1|PRKD 5600|707 1|MAPK1 4|8727|94 1|TIAM1| 23|9928|1 CTNNAL1 GO 0125|102 |NTN1|KIF GO:00072 1 -2.20021 M1 1 0 Biological 19 Ras protein signal transduction -2.20021 1.720778 2.82187 24156 402 873 25 2.863688 0.564477 76|22800| 14|RASGR -0.81076 0 145 0 0 -2.94443 4.19244 65 Processes 22821|23 P1|NET1| 433|2578 RRAS2|RA 0|50650|5 SA3|RHO 1715|573 Q|RASGR 81|85004| P3|ARHG 117178|1 EF3|RAB2 57285|40 3|RHOJ|R 1258 ERG|SSX2 IP|PRAG1| GRIN1|KC 2902|373 NA4|KCN 9|3759|37 J2|KCNJ5| 62|9312|1 GO KCNB2|C GO:00228 0369|271 1 -1.89076 M1 1 0 Molecular 21 voltage-gated cation channel activity -1.89076 2.17408 2.697754 24156 140 873 11 1.260023 0.37751 ACNG2|K -0.60668 0 97 0 0 -3.64921 2.294594 43 33|81033| Functions CNH5|KC 84329|11 NH6|HVC 7531|126 N1|TMC1| 755 LRRC38 BRCA1|C 672|894|1 CND2|CD 021|1545| K6|CYP1B 1591|178 1|CYP24A 9|1870|36 1|DNMT3 90|4233|5 B|E2F2|IT KEGG 156|6935| GB3|MET| 1 -1.89013 hsa05206 M1 1 0 24 MicroRNAs in cancer -1.89013 1.758301 2.554821 24156 299 873 19 2.176403 0.493838 -0.60636 0 265 1 1 -1.89013 1.758301 Pathway 7057|707 PDGFRA| 8|9134|94 ZEB1|THB 93|23414| S1|TIMP3| 85414|90 CCNE2|KI 427|1314 F23|ZFPM 05 2|SLC45A 3|BMF|TRI FN1|GAS 2335|262 2|WIPF1|S 0|7456|97 EMA3E|R 23|23433| HOQ|PAR GO 29780|55 GO:00083 VB|PHIP|T 1 -2.19412 M1 1 0 Biological 19 regulation of cell shape -2.19412 2.206818 2.993536 24156 163 873 13 1.489118 0.40992 023|5517 -0.80506 0 220 1 1 -2.19412 2.206818 60 BCCD1|F Processes 1|55785|5 GD6|RHO 7381|576 J|SHROO 19|15227 M3|FGD5| 3|157285 PRAG1 BRCA1|BR 672|675|9 CA2|CDK 83|2187|2 1|FANCB| 247|3838| FGF2|KPN 4361|475 A2|MRE1 1|5073|72 1|NEK2|P 70|7520|8 ARN|TTF1 317|9104| |XRCC5|C 10891|27 GO DC7|RGN| GO:00510 063|2898 1 -2.19282 M1 1 0 Biological 19 regulation of DNA metabolic process -2.19282 1.67886 2.79883 24156 445 873 27 3.092784 0.58593 PPARGC1 -0.80492 0 85 0 0 -3.87201 3.458763 52 4|54464|5 Processes A|ANKRD 5010|551 1|RGCC|X 37|55183| RN1|PAR 55196|79 PBP|FIGN| 075|8011 RIF1|RESF 9|80169|8 1|DSCC1| 3933|144 PIF1|CTC 455|4017 1|HDAC1 20 0|E2F7|FI ADORA2 A|ADORA 135|136|1 2B|AGTR2 86|196|12 |AHR|CM 40|1816|1 KLR1|DRD 907|1908| 5|EDN2|E 2902|326 DN3|GRI 9|3357|41 N1|HRH1| 61|4772|5 HTR2B|M GO 744|5795| C5R|NFA GO:00199 1 -2.19282 M1 1 0 Biological 19 second-messenger-mediated signaling -2.19282 1.67886 2.79883 24156 445 873 27 3.092784 0.58593 6915|705 TC1|PTHL -0.80492 0 115 0 0 -3.30059 4.19244 32 Processes 7|7852|91 H|PTPRJ|T 04|10149| BXA2R|T 10266|51 HBS1|CX 554|5578 CR4|RGN| 4|64123|8 ADGRG2| 4687|918 RAMP2|A 60|72923 CKR4|MC 0 TP2|ADG RL4|PPP1 R9B|CAL DTYMK|D 1841|185 UT|ENPP1 4|5167|51 |ENPP3|P KEGG 69|5558|6 1 -1.88377 hsa00240 M1 1 0 24 Pyrimidine metabolism -1.88377 2.394528 2.759685 24156 104 873 9 1.030928 0.341867 RIM2|RR -0.60121 0 266 1 1 -1.88377 7.905744 Pathway 241|7296| M2|TXNR 10587|84 D1|TXNR 618 D2|NT5C PRDM1|C DH5|CDK 639|1003| 6|MET|PE 1021|423 CAM1|PO 3|5175|54 DXL|PRO 20|5629|7 GO X1|TNFRS GO:00020 132|7852| 1 -2.18856 M1 1 0 Biological 19 epithelial cell development -2.18856 2.012371 2.920899 24156 220 873 16 1.832761 0.453972 F1A|CXCR -0.80144 0 127 0 0 -3.17736 9.223368 64 9497|230 Processes 4|SLC4A7| 86|26084| EXPH5|AR 30812|57 HGEF26|S 619|6410 OX8|SHR 2|117531 OOM3|T NMD|TM 1545|406 CYP1B1|L 0|6017|64 UM|RLBP 25|7054|7 1|SFRP5|T 078|9249| H|TIMP3| GO 10692|11 DHRS3|R GO:00509 1 -2.18856 M1 1 0 Biological 19 sensory perception of light stimulus -2.18856 2.012371 2.920899 24156 220 873 16 1.832761 0.453972 081|5390 RH|KERA| -0.80144 0 207 0 0 -2.26336 2.049637 53 Processes 4|54437|5 MYO3A|S 4567|573 EMA5B|D 69|64072| LL4|GJD2| 83872|15 CDH23|H 7506 MCN1|RD ADORA2 A|ADORA 135|136|9 2B|CDK1| 83|1062|1 CENPE|CE 063|1294| NPF|COL 1600|215 7A1|DAB 7|2890|47 1|F8|GRIA 51|5116|6 1|NEK2|P 790|8655| CNT|AUR 9423|949 KA|DYNLL 3|9662|97 1|NTN1|K 87|9814|9 IF23|CEP1 928|1012 35|DLGAP 5|10403|1 GO 5|SFI1|KIF GO:00516 0733|110 1 -2.18576 M1 1 0 Biological 19 organelle localization -2.18576 1.512027 2.724015 24156 732 873 40 4.581901 0.707671 14|RASGR -0.7996 0 12 0 0 -10.0997 6.06468 40 04|22871| Processes P1|NDC8 51203|54 0|PLK4|KI 820|5512 F2C|NLG 5|55165|5 N1|NUSA 5171|558 P1|NDE1| 35|79003| CEP192|C 79441|79 EP55|TBC 648|8018 CD1|CEN 4|81930|8 PJ|MIS12| 3540|941 HAUS3|M 21|12144 CPH1|CE 1|259266| P290|KIF1 347240 8A|NUF2| SYTL4|NE 1294|420 COL7A1| 8|9249|25 MEF2C|D 886|5114 HRS3|PO GO GO:00603 1|51715|5 C1A|INSI 1 -2.184 M1 1 0 Biological 19 bone morphogenesis -2.184 2.515464 3.084691 24156 110 873 10 1.145475 0.360151 -0.79842 0 11 0 0 -10.1305 3.03234 49 5790|116 G2|RAB23 Processes 039|1583 |CSGALN 26|64265 ACT1|OS 8 R2|FREM1 186|2247| AGTR2|F GO 3280|408 GF2|HES1 GO:00613 1 -2.18177 M1 1 0 Biological 19 renal tubule morphogenesis -2.18177 2.874816 3.190626 24156 77 873 8 0.91638 0.322501 9|4208|52 |SMAD4| -0.79696 0 10 0 0 -10.1376 3.952872 33 Processes 28|10736| MEF2C|P 30812 GF|SIX2|S BMP7|IN 655|3624| HBA|ITGA GO 3673|369 GO:00483 2|ITGB3|I 1 -2.18177 M1 1 0 Biological 19 mesoderm morphogenesis -2.18177 2.874816 3.190626 24156 77 873 8 0.91638 0.322501 0|3691|72 -0.79696 0 146 0 0 -2.93585 3.952872 32 TGB4|TX Processes 96|10736| NRD1|SIX 642658 2|SCX COL15A1| 1306|431 MMP1|M GO GO:00305 2|4316|95 MP7|ADA 1 -2.17721 M1 1 0 Biological 19 collagen catabolic process -2.17721 3.532354 3.364921 24156 47 873 6 0.687285 0.279617 -0.79432 0 88 0 0 -3.79065 3.532354 74 08|64066| MTS3|M Processes 79148 MP27|M MP28 ADORA2 135|2555| A|GABRA GO GO:00519 2556|255 2|GABRA 1 -2.17721 M1 1 0 Biological 19 synaptic transmission, GABAergic -2.17721 3.532354 3.364921 24156 47 873 6 0.687285 0.279617 -0.79432 0 112 0 0 -3.34087 10.06186 32 7|2565|22 3|GABRA Processes 871 4|GABRG 1|NLGN1 3672|367 ITGA1|IT Canonical 1 -1.87161 M47 M1 1 0 11 PID INTEGRIN CS PATHWAY -1.87161 4.256939 3.217428 24156 26 873 4 0.45819 0.22857 3|3690|36 GA2|ITGB -0.59298 0 186 0 0 -2.51714 11.06804 Pathways 91 3|ITGB4 947|3976| CD34|LIF| GO GO:00358 epithelial cell differentiation involved in 4208|542 MEF2C|P 1 -2.17721 M1 1 0 Biological 19 -2.17721 3.532354 3.364921 24156 47 873 6 0.687285 0.279617 -0.79432 0 118 0 0 -3.28677 7.905744 50 kidney development 0|10413|1 ODXL|YA Processes 0736 P1|SIX2 ACTN2|E 88|1908|2 GO DN3|FHL GO:00432 positive regulation of potassium ion 273|3759| 1 -2.17721 M1 1 0 Biological 19 -2.17721 3.532354 3.364921 24156 47 873 6 0.687285 0.279617 1|KCNJ2|L -0.79432 0 221 1 1 -2.17721 3.532354 68 transport 126755|1 Processes RRC38|A 96527 NO6 PRKAA2|E 5563|795 PM2A|TN GO 7|126282| GO:00320 FAIP8L1|S 1 -2.17721 M1 1 0 Biological 19 negative regulation of TOR signaling -2.17721 3.532354 3.364921 24156 47 873 6 0.687285 0.279617 143686|1 -0.79432 0 222 1 1 -2.17721 4.882959 07 ESN3|BM Processes 54743|65 T2|CAST 2968 OR1 AGTR2|C 186|1545| YP1B1|FG 2247|232 F2|FLT4|IT 4|3690|40 GB3|LOXL 17|4208|4 2|MEF2C| 233|5175| MET|PEC GO GO:00435 5587|562 AM1|PRK 1 -2.17552 M1 1 0 Biological 19 endothelial cell migration -2.17552 1.877614 2.860178 24156 280 873 19 2.176403 0.493838 -0.793 0 15 0 0 -9.08083 2.73285 42 9|6915|70 D1|PROX Processes 57|28984| 1|TBXA2R 54567|57 |THBS1|R 381|5760 GCC|DLL4 8|79812|1 |RHOJ|JC 47372 AD|MMR N2|CCBE ACTN2|C CN2|ECT2 88|1490|1 |GPM6B|K 894|2824| CNJ2|SM 3759|408 AD4|MEF 9|4208|42 2C|MET|N 33|4916|5 TRK3|PD 156|5629| GFRA|PR 6387|642 GO OX1|CXC GO:00329 2|7456|97 1 -2.17389 M1 1 0 Biological 19 regulation of actin filament-based process -2.17389 1.712259 2.795565 24156 404 873 25 2.863688 0.564477 L12|SFRP -0.79175 0 14 0 0 -9.68163 3.166231 70 23|10788| Processes 1|WIPF1|S 11346|22 EMA3E|IQ 843|2299 GAP2|SY 8|23433|2 NPO|PPM 8984|297 1E|LIMCH 66|50853| 1|RHOQ| 57381|84 RGCC|TM 952 OD3|VILL| RHOJ|CG ADORA2 135|794|1 A|CALB2| 385|1395| CREB1|CR 2048|290 HR2|EPH GO 2|5270|10 B2|GRIN1 GO:00508 1 -2.1724 M1 1 0 Biological 19 positive regulation of synaptic transmission -2.1724 2.193362 2.969286 24156 164 873 13 1.489118 0.40992 590|2287 |SERPINE -0.79103 0 49 0 0 -5.27843 3.609144 06 Processes 1|23237|5 2|SCGN|N 7616|347 LGN1|AR 730|7292 C|TSHZ3| 30 LRRTM1| CCR2 BRCA1|S 672|4089| MAD4|M 4208|491 EF2C|NTR 6|5563|56 K3|PRKAA 29|6491|9 2|PROX1| GO 662|9712| STIL|CEP1 GO:19021 1 -2.17025 M1 1 0 Biological 19 regulation of organelle assembly -2.17025 2.003265 2.901258 24156 221 873 16 1.832761 0.453972 10733|23 35|USP6N -0.78964 0 19 0 0 -7.81934 13.83505 15 Processes 216|5583 L|PLK4|TB 5|56890|8 C1D1|CE 5459|126 NPJ|MDM 731|3477 1|CEP295| 30 CCSAP|LR RTM1 AGTR2|C 186|947|1 D34|CRH 393|2335| BP|FN1|IN 3624|397 HBA|LIF|S 6|6422|71 FRP1|TNF GO 32|7133|1 RSF1A|TN GO:19035 1 -2.17025 M1 1 0 Biological 19 negative regulation of secretion by cell -2.17025 2.003265 2.901258 24156 221 873 16 1.832761 0.453972 1141|289 FRSF1B|IL -0.78964 0 204 0 0 -2.30866 2.003265 31 Processes 84|29091| 1RAPL1|R 94121|11 GCC|STX 4899|131 BP6|SYTL 450|7292 4|C1QTN 30 F3|CD200 R1|CCR2 BARD1|P 580|639|6 RDM1|BR 72|983|43 CA1|CDK 61|5563|5 1|MRE11| R-HSA- Reactome 1 -1.86697 M1 1 0 6 Regulation of TP53 Activity -1.86697 2.075258 2.642374 24156 160 873 12 1.37457 0.394068 600|5931| PRKAA2| -0.58985 0 101 0 0 -3.49696 2.706858 5633007 Gene Sets 6790|915 MAPK11| 6|22974|8 RBBP7|AU 0010 RKA|EXO 1|TPX2|R ACTN1|A 87|88|215 CTN2|F8| 7|2277|23 VEGFD|F GO GO:00025 35|3690|5 N1|ITGB3| 1 -2.16842 M1 1 0 Biological 19 platelet degranulation -2.16842 2.377899 3.026599 24156 128 873 11 1.260023 0.37751 -0.78819 0 81 0 0 -3.97669 6.510612 76 175|7057| PECAM1| Processes 7078|101 THBS1|TI 84|94121 MP3|LHF PL2|SYTL ALK|BMP 7|CRABP2 238|655|1 |DAB1|EP 382|1600| HB2|FN1| 2048|233 GOLGA4| 5|2803|29 GRIN1|IT 02|3706|4 PKA|MEF 208|4916| 2C|NTRK3 4974|558 |OMG|PR 7|6387|64 KD1|CXCL GO 22|6498|7 12|SFRP1| GO:00109 regulation of neuron projection 1 -2.16496 M1 1 0 Biological 19 -2.16496 1.621295 2.751463 24156 512 873 30 3.436426 0.616528 074|7852| SKIL|TIAM -0.78549 0 29 0 0 -6.42481 3.074456 75 development Processes 9423|972 1|CXCR4| 3|11141|2 NTN1|SE 2871|232 MA3E|IL1 37|26037| RAPL1|NL 27063|56 GN1|ARC| 963|8544 SIPA1L1| 2|151835| ANKRD1| 157285|2 RGMA|KN 85016 DC1|CPN E9|PRAG1 |ALKAL2 ACTN1|A DORA2A| 87|135|94 CD34|EN 7|954|204 TPD2|EPH 8|2157|28 B2|F8|GP 14|3673|3 5|ITGA2|I 690|5156| TGB3|PD 5270|691 GO GFRA|SER GO:00508 5|7056|70 1 -2.16372 M1 1 0 Biological 19 coagulation -2.16372 1.779948 2.812897 24156 342 873 22 2.520046 0.530463 PINE2|TB -0.78494 0 108 0 0 -3.3802 5.825285 17 57|7980|8 Processes XA2R|TH 357|2341 BD|THBS1 4|50808|1 |TFPI2|H3 39189|17 C10|ZFP 0692|196 M2|AK3|D 527|6536 GKK|ADA 04 MTS18|A NO6|H3C ADORA2 A|AGTR2| 135|186|9 CD34|CD 47|983|18 K1|ECT2|S 94|2040|3 TOM|HTR 357|4155| 2B|MBP|P 5116|517 CNT|PDZ 4|5600|81 K1|MAPK 11|8767|9 11|GPR68 GO 585|1012 GO:00512 |RIPK2|KIF 1 -2.16365 M1 1 0 Biological 19 positive regulation of protein transport -2.16365 1.688786 2.777354 24156 426 873 26 2.978236 0.575317 5|10631|2 -0.78494 0 133 0 0 -3.08066 2.143459 22 20B|RASG Processes 3086|233 RP1|POST 79|27063| N|EXPH5| 28984|51 ICE1|ANK 512|7967 RD1|RGC 9|80184|8 C|GTSE1| 4455|941 VTCN1|C 21|11489 EP290|EF 9 CAB7|SYT L4|C1QT 983|1385| CDK1|CR GO 2247|420 EB1|FGF2| GO:00550 positive regulation of cardiac muscle tissue 1 -2.16275 M1 1 0 Biological 19 -2.16275 3.124044 3.24262 24156 62 873 7 0.801833 0.301847 8|10413|2 MEF2C|Y -0.78442 0 117 0 0 -3.28848 6.510612 25 development Processes 3414|936 AP1|ZFP 49 M2|MYO ALDH1A3 220|1131| |CHRM3| 1134|139 CHRNA1| GO GO:00425 3|1395|36 CRHBP|C 1 -1.85853 M1 1 0 Molecular 21 hormone binding -1.85853 2.371723 2.727632 24156 105 873 9 1.030928 0.341867 -0.58321 0 269 1 1 -1.85853 2.371723 62 24|4161|4 RHR2|INH Functions 883|1026 BA|MC5R| 6 NPR3|RA MP2 ACTN1|A 87|88|282 CTN2|GP GO 4|3673|57 M6B|ITGA GO:00343 1 -2.15877 M1 1 0 Biological 19 adherens junction assembly -2.15877 2.649265 3.102271 24156 94 873 9 1.030928 0.341867 95|6422|7 2|PTPRJ|S -0.78119 0 39 0 0 -5.93077 3.633448 33 Processes 057|1026 FRP1|THB 6|22998 S1|RAMP 2|LIMCH1 BRCA1|D 672|1789| NMT3B|LI 3976|408 GO F|SMAD4| GO:00310 9|5081|55 1 -2.15877 M1 1 0 Biological 19 positive regulation of histone modification -2.15877 2.649265 3.102271 24156 94 873 9 1.030928 0.341867 PAX7|PRK -0.78119 0 184 0 0 -2.53893 6.917526 58 87|8726|1 Processes D1|EED|P 0891|551 PARGC1A 83 |RIF1 LGALS3|R 3958|910 GN|SFI1|R 4|9814|23 IMBP2|CE GO 504|5512 GO:00353 P192|KNL 1 -2.15688 M1 1 0 Biological 19 negative regulation of dephosphorylation -2.15688 2.492802 3.052407 24156 111 873 10 1.145475 0.360151 5|57082|5 -0.77968 0 199 0 0 -2.40034 2.76701 05 1|PPP4R4| Processes 7718|846 PPP1R9B| 87|84930| MASTL|EL 392617 FN1 ALK|BMP 7|CRABP2 238|655|1 |DAB1|EP 382|1600| HB2|FN1| 2048|233 GOLGA4| 5|2803|29 GRIN1|IT 02|3706|4 PKA|MEF 208|4916| 2C|NTRK3 4974|542 |OMG|PO 0|5587|63 DXL|PRK 87|6422|6 D1|CXCL1 498|7074| 2|SFRP1|S 7852|942 KIL|TIAM 3|9662|97 GO 1|CXCR4| GO:01200 regulation of plasma membrane bounded 12|9723|1 1 -2.15145 M1 1 0 Biological 19 -2.15145 1.513512 2.695131 24156 713 873 39 4.467354 0.699188 NTN1|CE -0.77463 0 29 0 0 -6.42481 3.074456 35 cell projection organization 0324|111 Processes P135|USP 41|22871| 6NL|SEM 23216|23 A3E|KLHL 237|2343 41|IL1RAP 3|26037|2 L1|NLGN 7063|544 1|TBC1D1 43|55835| |ARC|RH 56963|85 OQ|SIPA1 442|1518 L1|ANKR 35|15728 D1|ANLN| 5|285016| CENPJ|RG 10050665 MA|KND 8 C1|CPNE 9|PRAG1| CENPI|HE 2491|307 LLS|RBBP 0|5931|82 7|CHAF1B 08|8357|2 |H3C10|IT GO 3421|553 GB3BP|HJ GO:00314 1 -2.1509 M1 1 0 Biological 19 chromatin assembly -2.1509 2.180069 2.94521 24156 165 873 13 1.489118 0.40992 55|55506| URP|MAC -0.77446 0 31 0 0 -6.31644 12.57732 97 Processes 55839|57 ROH2A2| 082|9168 CENPN|K 7|401541| NL1|CEN 653604 PL|CENPP |H3C13 5125|515 PCSK5|PD GO GO:00485 6|8854|10 GFRA|AL 1 -2.1485 M1 1 0 Biological 19 embryonic digestive tract development -2.1485 4.069133 3.467685 24156 34 873 5 0.572738 0.255402 -0.77281 0 139 0 0 -2.9963 4.069133 66 736|9146 DH1A2|SI Processes 1 X2|PKDC AGTR2|IT GO 186|3672| GO:00109 GA1|ITGA 1 -2.1485 M1 1 0 Biological 19 positive regulation of phosphatase activity -2.1485 4.069133 3.467685 24156 34 873 5 0.572738 0.255402 3673|420 -0.77281 0 186 0 0 -2.51714 11.06804 22 2|MEF2C| Processes 8|9104 RGN ACTC1|A CTN2|AG 70|88|186 TR2|CDK1 |983|4089 GO |SMAD4| GO:00550 |4208|515 1 -2.14368 M1 1 0 Biological 19 cardiac muscle cell differentiation -2.14368 2.359466 2.997814 24156 129 873 11 1.260023 0.37751 MEF2C|P -0.76946 0 13 0 0 -9.83559 6.28866 07 6|5629|10 Processes DGFRA|P 529|5753 ROX1|NE 8|93649 BL|ALPK3| MYOCD ACTN2|A GTR2|BAR D1|CDK1| 88|186|58 ECT2|STO 0|983|189 M|EPHB2| 4|2040|20 GPC4|GP 48|2239|2 M6B|LGA 824|3958| LS3|LIF|P 3976|511 CNT|PDZ 6|5174|53 K1|PMAIP 66|5563|7 1|PRKAA2 GO 029|9134| GO:19038 |TFDP2|C 1 -2.14044 M1 1 0 Biological 19 regulation of cellular protein localization -2.14044 1.600323 2.721565 24156 536 873 31 3.550974 0.626348 9585|964 -0.76946 0 224 1 1 -2.14044 2.813909 27 CNE2|KIF Processes 8|10369|1 20B|GCC2 0403|233 |CACNG2| 79|23433| NDC80|IC 29969|51 E1|RHOQ| 512|5171 MDFIC|G 5|80184|8 TSE1|RAB 4455|846 23|CEP29 87|91461| 0|EFCAB7 131578 |PPP1R9B |PKDCC|L RRC15 ACTN2|C 88|1393|1 RHBP|ED 908|2040| N3|STOM 2048|227 |EPHB2|F 3|2890|29 HL1|GRIA 02|3759|4 1|GRIN1| 208|5174| KCNJ2|M GO 9104|103 EF2C|PDZ GO:19040 regulation of cation transmembrane 1 -2.1353 M1 1 0 Biological 19 -2.1353 1.7696 2.783795 24156 344 873 22 2.520046 0.530463 69|10891| K1|RGN|C -0.76946 0 45 0 0 -5.5147 9.223368 62 transport Processes 22871|23 ACNG2|P 237|5499 PARGC1A 7|57165|1 |NLGN1|A 17531|12 RC|TESC| 6755|196 GJC2|TM 527|7292 C1|LRRC3 30 8|ANO6|C CR2 GO 947|3672| CD34|ITG GO:00451 Cellular 3673|386 A1|ITGA2| 1 -1.85094 M1 1 0 20 basal part of cell -1.85094 3.018557 2.90199 24156 55 873 6 0.687285 0.279617 -0.57888 0 186 0 0 -2.51714 11.06804 78 Compone 1|4233|50 KRT14|M nts 10 ET|CLDN1 ALOX5|C 240|1240| MKLR1|E 1907|190 DN2|EDN 8|2277|32 3|VEGFD| 69|3672|3 HRH1|ITG GO GO:00305 958|5228| A1|LGALS 1 -2.13406 M1 1 0 Biological 19 leukocyte chemotaxis -2.13406 1.985299 2.862286 24156 223 873 16 1.832761 0.453972 -0.76946 0 42 0 0 -5.75682 3.654542 95 6387|705 3|PGF|CX Processes 7|7852|95 CL12|THB 47|79148| S1|CXCR4 196527|7 |CXCL14| 29230 MMP28|A NO6|CCR 2239|491 GPC4|NT GO 6|11141|2 RK3|IL1R GO:00991 1 -2.13239 M1 1 0 Biological 19 presynapse organization -2.13239 3.458763 3.301778 24156 48 873 6 0.687285 0.279617 2871|262 APL1|NLG -0.76946 0 63 0 0 -4.50244 10.37629 72 Processes 80|34773 N1|IL1RA 0 PL2|LRRT SMAD4|P 4089|562 GO ROX1|TN GO:00550 ventricular cardiac muscle tissue 9|7135|71 1 -2.13239 M1 1 0 Biological 19 -2.13239 3.458763 3.301778 24156 48 873 6 0.687285 0.279617 NI1|TNNT -0.76946 0 75 0 0 -4.23321 3.816566 10 morphogenesis 39|23414| Processes 2|ZFPM2| 54567 DLL4 CDH5|CD 1003|100 H7|CDH9| 5|1007|10 CDH10|C GO 08|1009|3 DH11|KP GO:00198 Cellular 838|5270| 1 -1.84732 M1 1 0 20 extrinsic component of plasma membrane -1.84732 2.062368 2.618899 24156 161 873 12 1.37457 0.394068 NA2|SERP -0.57675 0 32 0 0 -6.28754 6.917526 97 Compone 6503|707 INE2|SLA| nts 4|64072|8 TIAM1|C 5397|222 DH23|RG 256 S8|CDHR HELLS|M 3070|417 CM6|MRE 5|4361|75 11|XRCC5 20|8458|5 GO |TTF2|ERC GO:00043 4821|570 1 -1.84732 M1 1 0 Molecular 21 helicase activity -1.84732 2.062368 2.618899 24156 161 873 12 1.37457 0.394068 C6L|DDX2 -0.57675 0 261 0 0 -1.91252 4.882959 86 62|57696| Functions 4|DDX55| 79075|80 DSCC1|PI 119|9164 F1|TDRD1 6|254394 2|MCM9 BRCA2|M 675|4603| GO YBL1|TRIP GO:00071 9319|561 1 -2.13239 M1 1 0 Biological 19 male meiotic nuclear division -2.13239 3.458763 3.301778 24156 48 873 6 0.687285 0.279617 13|TEX14| -0.76946 0 226 1 1 -2.13239 11.06804 40 55|81930| Processes KIF18A|T 91646 DRD12 ADORA2 A|AGTR2| ALDH1A3 135|186|2 |SLC25A4| 20|291|11 CHAT|CO 03|1312|1 MT|CRAB 381|1382| P1|CRABP 1385|139 2|CREB1| 3|1545|15 CRHBP|C 83|1908|3 YP1B1|CY 624|3976| P11A1|ED GO 4089|512 N3|INHB GO:00108 1 -2.12933 M1 1 0 Biological 19 regulation of hormone levels -2.12933 1.597343 2.710637 24156 537 873 31 3.550974 0.626348 5|5156|64 A|LIF|SM -0.76946 0 227 1 1 -2.12933 1.597343 17 Processes 22|7074|8 AD4|PCS 111|8854| K5|PDGFR 9249|932 A|SFRP1|T 4|9563|10 IAM1|GP 891|2317 R68|ALD 8|30812|9 H1A2|DH 4121|114 RS3|HMG 899|1575 N3|H6PD| 06 PPARGC1 A|PASK|S OX8|SYTL 4|C1QTN CDK1|HT 983|3357| R2B|PDGF 5156|559 KEGG RA|PRKG 1 -1.84595 hsa04540 M1 1 0 24 Gap junction -1.84595 2.515464 2.75777 24156 88 873 8 0.91638 0.322501 3|56034|5 -0.57626 0 241 0 0 -2.04229 3.84307 Pathway 2|PDGFC| 7369|798 GJD2|TUB 61|81027 AL3|TUBB 186|655|2 AGTR2|B 247|3280| MP7|FGF GO GO:00609 3976|408 2|HES1|LI 1 -2.12929 M1 1 0 Biological 19 kidney morphogenesis -2.12929 2.621378 3.066059 24156 95 873 9 1.030928 0.341867 -0.76946 0 10 0 0 -10.1376 3.952872 93 9|5228|10 F|SMAD4| Processes 736|3081 PGF|SIX2| 2 SOX8 GO GO:19037 55835|85 CENPJ|CE 1 -2.12745 M1 1 0 Biological 19 positive regulation of centriole elongation -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 19 0 0 -7.81934 13.83505 24 459 P295 Processes GO GO:00611 negative regulation of chondrocyte 5744|359 PTHLH|RF 1 -2.12745 M1 1 0 Biological 19 -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 53 0 0 -4.98746 13.83505 82 development 845 LNB Processes GO GO:00516 2824|369 GPM6B|IT 1 -2.12745 M1 1 0 Biological 19 regulation of serotonin uptake -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 111 0 0 -3.35124 18.44674 11 0 GB3 Processes GO TNFRSF1 GO:00033 negative regulation of extracellular matrix 7132|713 1 -2.12745 M1 1 0 Biological 19 -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 A|TNFRSF -0.76946 0 113 0 0 -3.34087 13.83505 32 constituent secretion 3 Processes 1B ACTC1|A 70|88|204 CTN2|EP GO 7|3690|54 HB1|ITGB GO:00301 Cellular 20|10788| 3|PODXL|I 1 -1.83366 M1 1 0 20 filopodium -1.83366 2.349348 2.695943 24156 106 873 9 1.030928 0.341867 -0.56573 0 264 0 0 -1.89562 4.611684 75 Compone 22871|53 QGAP2|N nts 904|8468 LGN1|MY 7 O3A|PPP 1R9B BMP7|CC 655|1490| N2|FGF2| 2247|227 VEGFD|IN GO 7|3624|39 GO:00080 HBA|LIF|N 1 -1.82789 M1 1 0 Molecular 21 growth factor activity -1.82789 2.049637 2.595593 24156 162 873 12 1.37457 0.394068 76|4902|4 -0.56025 0 21 0 0 -7.62485 2.171781 83 RTN|OGN Functions 969|5228| |PGF|CXC 6387|299 L12|OSGI 48|56034 N1|PDGF GO GO:00381 chemokine (C-X-C motif) ligand 12 6387|785 CXCL12|C 1 -2.12745 M1 1 0 Biological 19 -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 151 0 0 -2.8845 27.6701 46 signaling pathway 2 XCR4 Processes ACTN2|IT 88|3672|3 GA1|ITGA KEGG Arrhythmogenic right ventricular 673|3690| 1 -1.81996 hsa05412 M1 1 0 24 -1.81996 2.690149 2.781109 24156 72 873 7 0.801833 0.301847 2|ITGB3|I -0.55321 0 186 0 0 -2.51714 11.06804 Pathway cardiomyopathy (ARVC) 3691|644 TGB4|SG 5|10369 CG|CACN GO GO:00606 negative regulation of prostatic bud 655|2321 BMP7|SU 1 -2.12745 M1 1 0 Biological 19 -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 153 0 0 -2.8845 27.6701 86 formation 3 LF1 Processes GO GO:00721 BMP7|SM 1 -2.12745 M1 1 0 Biological 19 kidney mesenchyme morphogenesis -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 655|4089 -0.76946 0 153 0 0 -2.8845 27.6701 31 AD4 Processes GO GO:00721 BMP7|SM 1 -2.12745 M1 1 0 Biological 19 metanephric mesenchyme morphogenesis -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 655|4089 -0.76946 0 153 0 0 -2.8845 27.6701 33 AD4 Processes GO GO:00070 mitotic chromosome movement towards 1062|978 CENPE|DL 1 -2.12745 M1 1 0 Biological 19 -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 155 0 0 -2.83885 13.83505 79 spindle pole 7 GAP5 Processes GO GO:00359 64102|64 TNMD|SC 1 -2.12745 M1 1 0 Biological 19 tendon cell differentiation -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 159 0 0 -2.83085 13.83505 90 2658 X Processes GO GO:00359 64102|64 TNMD|SC 1 -2.12745 M1 1 0 Biological 19 tendon formation -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 159 0 0 -2.83085 13.83505 92 2658 X Processes GO AURKA|KI 6790|958 GO:00974 Cellular F20B|KAT 1 -1.81429 M1 1 0 20 mitotic spindle pole -1.81429 4.099275 3.120064 24156 27 873 4 0.45819 0.22857 5|11104|2 -0.55124 0 80 0 0 -4.01173 9.223368 31 Compone NA1|ASP 59266 nts M GO GO:00148 1907|190 EDN2|ED 1 -2.12745 M1 1 0 Biological 19 vein smooth muscle contraction -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 -0.76946 0 187 0 0 -2.48174 18.44674 26 8 N3 Processes GO UGDH|CS GO:00463 7358|557 1 -2.12745 M1 1 0 Biological 19 UDP-glucuronate metabolic process -2.12745 13.83505 4.970983 24156 4 873 2 0.229095 0.161809 GALNACT -0.76946 0 228 1 1 -2.12745 13.83505 98 90 Processes 1 CRABP2| 1382|160 DAB1|EP 0|2048|23 HB2|FN1| 35|2803|2 GOLGA4| GO 902|4916| GRIN1|NT GO:00507 1 -2.12508 M1 1 0 Biological 19 regulation of axonogenesis -2.12508 2.093954 2.892231 24156 185 873 14 1.603666 0.425147 4974|638 RK3|OMG -0.76882 0 29 0 0 -6.42481 3.074456 70 Processes 7|6498|70 |CXCL12|S 74|9423|9 KIL|TIAM 723|2603 1|NTN1|S 7 EMA3E|SI PA1L1 ACTL6A|C 86|2491|3 ENPI|HEL 070|5081| LS|PAX7|R 5931|103 BBP7|NP 60|23421| GO M3|ITGB3 GO:00063 54108|55 1 -2.12508 M1 1 0 Biological 19 chromatin remodeling -2.12508 2.093954 2.892231 24156 185 873 14 1.603666 0.425147 BP|CHRA -0.76882 0 31 0 0 -6.31644 12.57732 38 355|5583 Processes C1|HJURP 9|57082|7 |CENPN|K 9723|916 NL1|SUV3 87|40154 9H2|CEN 1 PL|CENPP 835|983|6 CASP2|C GO 790|7029| DK1|AUR GO:00315 1 -2.12501 M1 1 0 Biological 19 mitotic G1 DNA damage checkpoint -2.12501 3.074456 3.192421 24156 63 873 7 0.801833 0.301847 28984|51 KA|TFDP2 -0.76882 0 30 0 0 -6.32789 4.035223 71 Processes 512|1444 |RGCC|GT 55 SE1|E2F7 835|983|6 CASP2|C GO 790|7029| DK1|AUR GO:00448 1 -2.12501 M1 1 0 Biological 19 mitotic G1/S transition checkpoint -2.12501 3.074456 3.192421 24156 63 873 7 0.801833 0.301847 28984|51 KA|TFDP2 -0.76882 0 30 0 0 -6.32789 4.035223 19 Processes 512|1444 |RGCC|GT 55 SE1|E2F7 CHRNA1| GABRA2| 1134|255 GABRA3| 5|2556|25 GABRA4| 57|2565|2 GABRG1| 890|2902| GRIA1|GR 3739|375 IN1|KCNA 9|3762|63 4|KCNJ2| 28|7223|9 KCNJ5|SC GO GO:00052 312|1036 N3A|TRP 1 -1.81172 M1 1 0 Molecular 21 ion channel activity -1.81172 1.611851 2.425539 24156 412 873 24 2.749141 0.553399 -0.55124 0 97 0 0 -3.64921 2.294594 16 9|22821|2 C4|KCNB Functions 7133|550 2|CACNG 13|81033| 2|RASA3| 83959|84 KCNH5|M 329|1175 CUB|KCN 31|12675 H6|SLC4A 5|133060| 11|HVCN 196527 1|TMC1|L RRC38|O TOP1|AN EPHB1|EP 2047|204 HB2|ITPK GO 8|3706|70 GO:00609 A|TIAM1| 1 -2.12501 M1 1 0 Biological 19 dendritic spine morphogenesis -2.12501 3.074456 3.192421 24156 63 873 7 0.801833 0.301847 74|22871| -0.76882 0 107 0 0 -3.41128 3.074456 97 NLGN1|A Processes 23237|26 RC|SIPA1 037 L1 CREB1|FG F2|HTR2B 1385|224 |PDGFRA| 7|3357|51 PRKD1|T 56|5587|7 GO NFRSF1A| GO:00458 positive regulation of lipid metabolic 132|9104| 1 -2.12027 M1 1 0 Biological 19 -2.12027 2.243522 2.938309 24156 148 873 12 1.37457 0.394068 RGN|PPA -0.76444 0 232 1 1 -2.12027 5.534021 34 process 10891|57 Processes RGC1A|DI 540|8541 SP3|SLC4 4|157506| 5A3|RDH 388121 10|TNFAI P8L3 ALDH1A3 |COMT|C 220|1312| RABP1|CR 1381|138 ABP2|CYP GO 2|1545|15 GO:00347 1B1|CYP1 1 -2.11926 M1 1 0 Biological 19 cellular hormone metabolic process -2.11926 2.341316 2.969295 24156 130 873 11 1.260023 0.37751 83|5156|8 -0.76415 0 131 0 0 -3.08989 10.37629 54 1A1|PDG Processes 854|9249| FRA|ALD 10891|15 H1A2|DH 7506 RS3|PPAR GC1A|RD CDH5|EP 1003|204 HB1|HES1 7|3280|64 |SFRP5|TC 25|6939|7 F15|WEE1 465|9585| |KIF20B|N GO 10403|11 GO:00071 establishment or maintenance of cell DC80|KIF 1 -2.11619 M1 1 0 Biological 19 -2.11619 1.976436 2.842951 24156 224 873 16 1.832761 0.453972 004|2343 -0.76144 0 233 1 1 -2.11619 1.976436 63 polarity 2C|RHOQ Processes 3|29780|5 |PARVB|N 4820|573 DE1|RHO 81|79648| J|MCPH1| 84612|28 PARD6B|L 4217 AMA1 ACTC1|A GTR2|CC 70|186|14 N2|EDN2| 90|1907|1 EDN3|KC 908|3759| NJ2|KCNJ 3762|409 5|SMAD5| GO 0|4632|64 GO:00600 MYL1|SG 1 -2.11233 M1 1 0 Biological 19 heart contraction -2.11233 1.851169 2.79397 24156 284 873 19 2.176403 0.493838 45|7054|7 -0.75799 0 61 0 0 -4.53228 18.44674 47 CG|TH|TN Processes 135|7136| NI1|TNNI 7139|714 2|TNNT2| 0|7852|10 TNNT3|C 369|1065 XCR4|CA 9|64091 CNG2|CE LF2|POPD R-HSA- Reactome 2618|547 GART|PP 1 -1.81071 M1 1 0 6 Nucleobase biosynthesis -1.81071 5.534021 3.401282 24156 15 873 3 0.343643 0.198061 -0.55124 0 135 0 0 -3.06206 13.83505 8956320 Gene Sets 1|10606 AT|PAICS GO CRABP1| GO:00198 1381|138 1 -1.81071 M1 1 0 Molecular 21 retinol binding -1.81071 5.534021 3.401282 24156 15 873 3 0.343643 0.198061 CRABP2|R -0.55124 0 173 0 0 -2.66202 6.917526 41 2|6017 Functions LBP1 R-HSA- Reactome 2814|367 GP5|ITGA 1 -1.81071 M1 1 0 6 Platelet Adhesion to exposed collagen -1.81071 5.534021 3.401282 24156 15 873 3 0.343643 0.198061 -0.55124 0 186 0 0 -2.51714 11.06804 75892 Gene Sets 2|3673 1|ITGA2 AGTR2|C ALB2|CD 186|794|1 H5|CMKL 003|1240| R1|SLC31 1317|135 A1|CP|DR 6|1816|19 D5|EDN2| 07|1908|2 EDN3|FG 247|2512| F2|FTL|GP 2840|284 R17|LPAR 6|2890|29 4|GRIA1| 02|3263|3 GRIN1|HP 357|3759| X|HTR2B| GO 4089|515 KCNJ2|S GO:00300 1 -2.11202 M1 1 0 Biological 19 cellular cation homeostasis -2.11202 1.523503 2.66507 24156 672 873 37 4.238259 0.68184 6|6341|63 MAD4|PD -0.75799 0 94 0 0 -3.67332 2.548562 03 Processes 87|6869|6 GFRA|SC 915|7223| O1|CXCL 7852|910 12|TACR1 4|9497|10 |TBXA2R| 590|1134 TRPC4|CX 6|22821|3 CR4|RGN| 0001|515 SLC4A7|S 54|55013| CGN|SYN 64072|83 PO|RASA 959|7292 3|ERO1A| 30 ACKR4|M CUB|CDH 23|SLC4A CHRNA1| 1134|204 EPHB1|M 7|4208|50 EF2C|PAX 81|7093|9 7|TLL2|M GO 242|1032 GO:00605 SC|KLHL4 1 -2.10856 M1 1 0 Biological 19 skeletal muscle organ development -2.10856 2.15396 2.897571 24156 167 873 13 1.489118 0.40992 4|27063|3 -0.75501 0 124 0 0 -3.22859 6.58812 38 1|ANKRD Processes 0812|574 1|SOX8|N 86|64091| LN|POPD 93649|64 C2|MYOC 2658 D|SCX 88|1908|2 ACTN2|E 048|3759| DN3|EPH 5174|910 B2|KCNJ2 4|10369|2 |PDZK1|R GO 3237|234 GN|CACN GO:00347 positive regulation of transmembrane 1 -2.10833 M1 1 0 Biological 19 -2.10833 2.024642 2.852846 24156 205 873 15 1.718213 0.439813 33|54997| G2|ARC|R -0.75501 0 45 0 0 -5.5147 9.223368 64 transport Processes 57165|12 HOQ|TES 6755|196 C|GJC2|LR 527|7292 RC38|AN 30|10050 O6|CCR2| 6658 OCLN AGTR2|F 186|2273| HL1|INHB 3624|408 A|SMAD4 9|5167|52 |ENPP1|S GO 70|5795|5 ERPINE2| GO:00303 1 -2.10529 M1 1 0 Biological 19 negative regulation of cell growth -2.10529 2.082696 2.870253 24156 186 873 14 1.603666 0.425147 931|6422| PTPRJ|RB -0.75233 0 104 0 0 -3.44559 2.082696 08 Processes 9423|972 BP7|SFRP 3|29948|8 1|NTN1|S 4687|850 EMA3E|O 04 SGIN1|PP P1R9B|RE CCND2|C 894|983|8 DK1|CDC 317|8318| GO 7|CDC45| GO:19019 positive regulation of mitotic cell cycle 9787|270 1 -2.10027 M1 1 0 Biological 19 -2.10027 2.594072 3.030309 24156 96 873 9 1.030928 0.341867 DLGAP5| -0.74803 0 51 0 0 -5.22312 2.912642 92 phase transition 85|28984| Processes MTBP|RG 29766|51 CC|TMO 514 D3|DTL VEGFD|FL 2277|232 T4|ITGB3| 4|3690|52 GO PGF|PRK GO:00480 vascular endothelial growth factor receptor 28|5587|5 1 -2.10027 M1 1 0 Biological 19 -2.10027 2.594072 3.030309 24156 96 873 9 1.030928 0.341867 D1|MAPK -0.74803 0 68 0 0 -4.38679 2.76701 10 signaling pathway 600|2321 Processes 11|SULF1| 3|64102|7 TNMD|M 9812 MRN2 AGTR2|A HR|BRCA 186|196|6 1|CD34|C 72|947|10 ENPF|CRE 63|1385|1 B1|E2F2|E 870|2103| SRRB|HES 3280|408 1|SMAD4| 9|4208|47 MEF2C|N 72|5308|5 FATC1|PI 629|6095| TX2|PRO 7029|854 X1|RORA| 3|9096|93 TFDP2|L GO 24|10413| GO:00081 MO4|TBX 1 -1.80825 M1 1 0 Molecular 21 transcription factor binding -1.80825 1.469581 2.366671 24156 659 873 35 4.009164 0.663949 10736|10 -0.55124 0 82 0 0 -3.95806 2.352519 34 18|HMGN Functions 891|2341 3|YAP1|SI 4|27063|2 X2|PPAR 9969|308 GC1A|ZFP 12|51141| M2|ANKR 51523|54 D1|MDFI 892|5550 C|SOX8|I 2|85004|9 NSIG2|CX 3649|144 XC5|NCA 455|1615 PG2|HES6 82|64265 |RERG|MY 8 OCD|E2F 7|DNAAF BARD1|B 580|672|6 KEGG RCA1|BR 1 -1.80786 hsa03440 M1 1 0 24 Homologous recombination -1.80786 3.374403 2.946415 24156 41 873 5 0.572738 0.255402 75|4361|1 -0.55124 0 70 0 0 -4.32747 27.6701 Pathway CA2|MRE 46956 11|EME1 1462|223 VCAN|GP R-HSA- Reactome Diseases associated with 1 -1.80786 M1 1 0 6 -1.80786 3.374403 2.946415 24156 41 873 5 0.572738 0.255402 9|4060|49 C4|LUM| -0.55124 0 96 0 0 -3.66151 10.37629 3560782 Gene Sets glycosaminoglycan metabolism 69|11081 OGN|KER BMP7|FZ 655|2535| D2|HES1| 3280|408 SMAD4| GO 9|4208|56 GO:00032 MEF2C|P 1 -2.09513 M1 1 0 Biological 19 cardiac chamber morphogenesis -2.09513 2.323444 2.941038 24156 131 873 11 1.260023 0.37751 29|7135|7 -0.74507 0 75 0 0 -4.23321 3.816566 06 ROX1|TN Processes 139|9249| NI1|TNNT 23414|54 2|DHRS3| 567 ZFPM2|D ACTN2|C 88|815|29 AMK2A|G R-HSA- Reactome Assembly and cell surface presentation of 1 -1.80786 M1 1 0 6 -1.80786 3.374403 2.946415 24156 41 873 5 0.572738 0.255402 02|79861| RIN1|TUB -0.55124 0 164 0 0 -2.711 11.06804 9609736 Gene Sets NMDA receptors 81027 AL3|TUBB 1 INHBA|IT GO 3624|367 GO:00483 GA2|ITGB 1 -2.0944 M1 1 0 Biological 19 mesodermal cell differentiation -2.0944 3.952872 3.385105 24156 35 873 5 0.572738 0.255402 3|3690|36 -0.74507 0 146 0 0 -2.93585 3.952872 33 3|ITGB4|SI Processes 91|10736 X2 BRCA1|C GO 672|983|4 GO:00315 DK1|MRE 1 -2.0944 M1 1 0 Biological 19 G2 DNA damage checkpoint -2.0944 3.952872 3.385105 24156 35 873 5 0.572738 0.255402 361|5151 -0.74507 0 208 0 0 -2.2632 4.323454 72 11|DTL|CL Processes 4|63967 SPN 4883|642 NPR3|SFR GO GO:00336 2|10516|3 P1|FBLN5| 1 -2.0944 M1 1 0 Biological 19 osteoblast proliferation -2.0944 3.952872 3.385105 24156 35 873 5 0.572738 0.255402 -0.74507 0 234 1 1 -2.0944 3.952872 87 0812|116 SOX8|OS Processes 039 R2 672|675|1 BRCA1|BR 021|1870| CA2|CDK 2247|232 6|E2F2|FG KEGG 1 -1.80678 hsa05224 M1 1 0 24 Breast cancer -1.80678 2.113688 2.595506 24156 144 873 11 1.260023 0.37751 4|2535|32 F2|FLT4|F -0.55045 0 147 0 0 -2.92937 2.388786 Pathway 80|8325|5 ZD2|HES1 4567|803 |FZD8|DL 26 L4|WNT1 ACTC1|A GTR2|CYP 70|186|15 1B1|FGF2| 45|2247|2 FLT4|ITG 324|3673| A2|ITGB3| 3690|401 LOXL2|M 7|4208|42 EF2C|MET 33|5175|5 GO |PECAM1| GO:00901 587|5629| 1 -2.09243 M1 1 0 Biological 19 tissue migration -2.09243 1.729381 2.730177 24156 368 873 23 2.634593 0.542066 PRKD1|PR -0.74507 0 15 0 0 -9.08083 2.73285 30 6915|705 Processes OX1|TBX 7|28984|2 A2R|THBS 9941|544 1|RGCC|P 43|54567| KN3|ANL 57381|57 N|DLL4|R 608|7981 HOJ|JCAD 2|147372 |MMRN2| CCBE1 GO BRCA1|C GO:00108 negative regulation of centrosome 672|899|5 1 -2.09129 M1 1 0 Biological 19 -2.09129 6.917526 3.970245 24156 12 873 3 0.343643 0.198061 CNF|MD -0.74507 0 70 0 0 -4.32747 27.6701 26 duplication 6890 Processes M1 ACTC1|IT 70|3672|3 GA1|ITGA 673|3690| KEGG 2|ITGB3|I 1 -1.79163 hsa05414 M1 1 0 24 Dilated cardiomyopathy -1.79163 2.459565 2.686172 24156 90 873 8 0.91638 0.322501 3691|644 -0.53615 0 186 0 0 -2.51714 11.06804 Pathway TGB4|SG 5|7139|10 CG|TNNT 369 2|CACNG GO GO:00423 4060|496 LUM|OG 1 -2.09129 M1 1 0 Biological 19 keratan sulfate catabolic process -2.09129 6.917526 3.970245 24156 12 873 3 0.343643 0.198061 -0.74507 0 96 0 0 -3.66151 10.37629 40 9|11081 N|KERA Processes GO BMP7|TN GO:19023 regulation of apoptotic process involved in 655|7132| 1 -2.09129 M1 1 0 Biological 19 -2.09129 6.917526 3.970245 24156 12 873 3 0.343643 0.198061 FRSF1A|T -0.74507 0 113 0 0 -3.34087 13.83505 37 morphogenesis 7133 Processes NFRSF1B GO GO:00613 cardiac neural crest cell differentiation 655|3280| BMP7|HE 1 -2.09129 M1 1 0 Biological 19 -2.09129 6.917526 3.970245 24156 12 873 3 0.343643 0.198061 -0.74507 0 198 0 0 -2.41795 18.44674 07 involved in heart development 5308 S1|PITX2 Processes GO GO:00613 cardiac neural crest cell development 655|3280| BMP7|HE 1 -2.09129 M1 1 0 Biological 19 -2.09129 6.917526 3.970245 24156 12 873 3 0.343643 0.198061 -0.74507 0 198 0 0 -2.41795 18.44674 08 involved in heart development 5308 S1|PITX2 Processes GO 126731|2 CCSAP|G GO:00033 1 -2.09129 M1 1 0 Biological 19 regulation of cilium beat frequency -2.09129 6.917526 3.970245 24156 12 873 3 0.343643 0.198061 46176|33 AS2L2|CC -0.74507 0 235 1 1 -2.09129 7.905744 56 Processes 9829 DC39 ALOX5|BI 240|332|2 RC5|FGF2 247|2335| R-HSA- Reactome |FN1|LIF| 1 -1.78502 M1 1 0 6 Interleukin-4 and Interleukin-13 signaling -1.78502 2.305842 2.633626 24156 108 873 9 1.030928 0.341867 3976|431 -0.53125 0 244 0 0 -2.00053 2.305842 6785807 Gene Sets MMP1|R 2|6095|69 ORA|ZEB 35|7133 1|TNFRSF CHRNA1| GABRA2| 1134|255 GABRA3| 5|2556|25 GABRA4| 57|2565|2 GABRG1| 890|2902| GRIA1|GR 3739|375 IN1|KCNA GO 9|3762|63 4|KCNJ2| GO:00228 1 -1.78353 M1 1 0 Molecular 21 ion gated channel activity -1.78353 1.687201 2.426433 24156 328 873 20 2.290951 0.50637 28|9312|1 KCNJ5|SC -0.53004 0 97 0 0 -3.64921 2.294594 39 Functions 0369|228 N3A|KCN 21|27133| B2|CACN 81033|84 G2|RASA 329|1175 3|KCNH5| 31|12675 KCNH6|H 5|196527 VCN1|TM C1|LRRC3 8|ANO6 CD34|PD 947|5156| GO GFRA|SER GO:00301 5270|705 1 -2.08883 M1 1 0 Biological 19 negative regulation of blood coagulation -2.08883 3.388176 3.24029 24156 49 873 6 0.687285 0.279617 PINE2|TH -0.74401 0 108 0 0 -3.3802 5.825285 95 6|7057|17 Processes BD|THBS1 0692 |ADAMTS CHRM3|C 1131|149 GO CN2|EDN GO:00459 0|1907|36 1 -2.08883 M1 1 0 Biological 19 positive regulation of muscle contraction -2.08883 3.388176 3.24029 24156 49 873 6 0.687285 0.279617 2|ITGA2|T -0.74401 0 115 0 0 -3.30059 4.19244 33 73|6915|9 Processes BXA2R|M 3649 YOCD EPHB1|M 2047|420 GO EF2C|TLL GO:00486 regulation of skeletal muscle tissue 8|7093|10 1 -2.08883 M1 1 0 Biological 19 -2.08883 3.388176 3.24029 24156 49 873 6 0.687285 0.279617 2|KLHL41| -0.74401 0 124 0 0 -3.22859 6.58812 41 development 324|5748 Processes NLN|MY 6|93649 OCD 835|983|6 CASP2|C GO 790|7029| DK1|AUR GO:00447 1 -2.0881 M1 1 0 Biological 19 G1 DNA damage checkpoint -2.0881 3.026418 3.143212 24156 64 873 7 0.801833 0.301847 28984|51 KA|TFDP2 -0.74398 0 30 0 0 -6.32789 4.035223 83 Processes 512|1444 |RGCC|GT 55 SE1|E2F7 CDH5|CD 1003|100 H7|CDH9| 5|1007|10 CDH10|C 08|1009|5 DH11|PE GO 175|5129 CAM1|PC GO:00071 homophilic cell adhesion via plasma 1 -2.08771 M1 1 0 Biological 19 -2.08771 2.141139 2.874004 24156 168 873 13 1.489118 0.40992 4|57526|6 DH12|PC -0.74393 0 32 0 0 -6.28754 6.917526 56 membrane adhesion molecules Processes 4072|648 DH19|CD 81|83872| H23|PCD 91624|22 H20|HMC 2256 N1|NEXN| CDHR3 ALDH1A3 220|655|1 |BMP7|C 295|2047| GO OL8A1|EP GO:00485 2048|530 1 -2.07773 M1 1 0 Biological 19 camera-type eye morphogenesis -2.07773 2.427202 2.957629 24156 114 873 10 1.145475 0.360151 HB1|EPH -0.73594 0 7 0 0 -11.4306 6.148912 93 8|5629|69 Processes B2|PITX2| 35|7054|3 PROX1|ZE 0812 B1|TH|SO AGTR2|D 186|1600| AB1|GAR 2618|290 T|GRIN1|S GO GO:00220 2|5270|56 ERPINE2| 1 -2.07773 M1 1 0 Biological 19 metencephalon development -2.07773 2.427202 2.957629 24156 114 873 10 1.145475 0.360151 -0.73594 0 92 0 0 -3.73382 12.29782 37 29|6095|9 PROX1|R Processes 928|1089 ORA|KIF1 1|85442 4|PPARG C1A|KND VCAN|GP 1462|223 C4|LUM| 9|4060|49 OGN|UG GO 69|7358|9 GO:00060 DH|HS2S 1 -2.07773 M1 1 0 Biological 19 aminoglycan biosynthetic process -2.07773 2.427202 2.957629 24156 114 873 10 1.145475 0.360151 653|1108 -0.73594 0 96 0 0 -3.66151 10.37629 23 T1|KERA| Processes 1|51363|5 CHST15|C 5790|930 SGALNAC 10 T1|B3GNT CDK6|CD 1021|103 KN2B|E2F 0|1870|30 2|H2AZ1| R-HSA- Reactome 15|5600|5 1 -1.76975 M1 1 0 6 Oxidative Stress Induced Senescence -1.76975 2.178748 2.57897 24156 127 873 10 1.145475 0.360151 MAPK11| -0.51882 0 275 1 1 -1.76975 3.14433 2559580 Gene Sets 931|7029| RBBP7|TF 8357|872 DP2|H3C 6|653604 10|EED|H BMP7|GP 655|2882| X7|HBA1| 3039|574 PTGS1|TX GO 2|7296|91 GO:19907 NRD1|RG 1 -2.07773 M1 1 0 Biological 19 cellular detoxification -2.07773 2.427202 2.957629 24156 114 873 10 1.145475 0.360151 04|10516| -0.73594 0 120 0 0 -3.26614 6.385408 48 N|FBLN5| Processes 10587|13 TXNRD2| 7902|140 PXDNL|S 809 RXN1 ADORA2 A|XIAP|BI 135|331|3 RC5|C4A| 32|720|12 COL7A1|S 94|5270|6 ERPINE2| 692|7057| SPINT1|T GO 7078|707 HBS1|TIM GO:00104 1 -2.07762 M1 1 0 Biological 19 negative regulation of peptidase activity -2.07762 1.872413 2.770423 24156 266 873 18 2.061856 0.480948 9|7980|92 P3|TIMP4| -0.73594 0 116 0 0 -3.2998 2.23146 66 Processes 32|55031| TFPI2|PTT 79444|80 G1|USP47 760|1171 |BIRC7|ITI 66|12485 H5|WFIKK 7|140902 N1|WFIKK N2|R3HD ML CALB2|C 794|1131| HRM3|CR 1393|139 GO HBP|CRH 5|2902|36 GO:00443 Cellular R2|GRIN1 1 -1.76626 M1 1 0 20 neuron projection terminus -1.76626 2.084734 2.545627 24156 146 873 11 1.260023 0.37751 73|5179|7 -0.5178 0 86 0 0 -3.83907 2.396623 06 Compone |ITGA2|PE 054|8492| nts NK|TH|PR 10590|22 SS12|SCG 2256 N|CDHR3 672|835|9 BRCA1|C 83|4361|6 ASP2|CD 790|7029| K1|MRE1 GO GO:00000 28984|51 1|AURKA| 1 -2.07569 M1 1 0 Biological 19 DNA damage checkpoint -2.07569 2.213608 2.887057 24156 150 873 12 1.37457 0.394068 -0.7354 0 30 0 0 -6.32789 4.035223 77 512|5151 TFDP2|RG Processes 4|63967|1 CC|GTSE1 44455|14 |DTL|CLSP 6956 N|E2F7|E EPHB1|EP 2047|204 HB2|GRIN R-HSA- Reactome 1 -1.76556 M1 1 0 6 EPHB-mediated forward signaling -1.76556 3.29406 2.881283 24156 42 873 5 0.572738 0.255402 8|2902|70 1|TIAM1| -0.5178 0 126 0 0 -3.20893 9.223368 3928662 Gene Sets 74|64283 ARHGEF2 8 COL4A5| 1287|128 COL5A1| R-HSA- Reactome 9|1299|49 1 -1.76556 M1 1 0 6 NCAM1 interactions -1.76556 3.29406 2.881283 24156 42 873 5 0.572738 0.255402 COL9A3| -0.5178 0 144 0 0 -2.96243 3.816566 419037 Gene Sets 02|13187 NRTN|CO 3 L6A6 BMP7|CR 655|1382| ABP2|FBN 2201|408 2|SMAD4| 9|5125|88 PCSK5|AL GO 54|51098| GO:00351 DH1A2|IF 1 -2.07569 M1 1 0 Biological 19 appendage morphogenesis -2.07569 2.213608 2.887057 24156 150 873 12 1.37457 0.394068 91461|11 -0.7354 0 176 0 0 -2.63058 4.19244 07 T52|PKDC Processes 6039|157 C|OSR2|R 506|3404 DH10|RSP 19|34164 O2|FREM 0 2 BMP7|CR 655|1382| ABP2|FBN 2201|408 2|SMAD4| 9|5125|88 PCSK5|AL GO 54|51098| GO:00351 DH1A2|IF 1 -2.07569 M1 1 0 Biological 19 limb morphogenesis -2.07569 2.213608 2.887057 24156 150 873 12 1.37457 0.394068 91461|11 -0.7354 0 176 0 0 -2.63058 4.19244 08 T52|PKDC Processes 6039|157 C|OSR2|R 506|3404 DH10|RSP 19|34164 O2|FREM 0 2 4060|496 LUM|OG R-HSA- Reactome 1 -1.75965 M1 1 0 6 Keratan sulfate biosynthesis -1.75965 3.952872 3.027291 24156 28 873 4 0.45819 0.22857 9|11081|9 N|KERA|B -0.5178 0 96 0 0 -3.66151 10.37629 2022854 Gene Sets 3010 3GNT7 655|3624| BMP7|IN 3976|642 HBA|LIF|S 2|6790|72 FRP1|AUR GO GO:20002 72|9319|1 KA|TTK|T 1 -2.07569 M1 1 0 Biological 19 regulation of reproductive process -2.07569 2.213608 2.887057 24156 150 873 12 1.37457 0.394068 -0.7354 0 217 0 0 -2.20452 9.223368 41 0184|232 RIP13|LHF Processes 13|23414| PL2|SULF 64750|25 1|ZFPM2| 9266 SMURF2| CRABP2| 1382|160 DAB1|EP 0|2048|23 HB2|FN1| 35|2803|2 GOLGA4| 902|3706| GRIN1|IT 4916|497 PKA|NTR GO 4|6387|64 K3|OMG| GO:00107 regulation of cell morphogenesis involved 1 -2.07306 M1 1 0 Biological 19 -2.07306 1.802613 2.740509 24156 307 873 20 2.290951 0.50637 98|7074|9 CXCL12|S -0.73312 0 29 0 0 -6.42481 3.074456 69 in differentiation Processes 423|9723| KIL|TIAM 10631|11 1|NTN1|S 141|2287 EMA3E|P 1|23237|2 OSTN|IL1 6037|854 RAPL1|NL 42 GN1|ARC| SIPA1L1|K CDK1|NE 983|4751| K2|PCNT| 5116|599 RFX4|DY 2|8655|96 NLL1|CEP 62|9712|9 135|USP6 814|1073 NL|SFI1|P 3|23216|2 LK4|TBC1 5886|510 D1|POC1 GO 98|51715| GO:00602 A|IFT52|R 1 -2.06767 M1 1 0 Biological 19 cilium assembly -2.06767 1.698421 2.696049 24156 391 873 24 2.749141 0.553399 54820|55 -0.72842 0 12 0 0 -10.0997 6.06468 71 AB23|ND Processes 112|5512 E1|WDR6 5|55835|7 0|CEP192| 9441|801 CENPJ|H 84|11717 AUS3|CEP 8|121441| 290|SSX2I 161582|3 P|NEDD1| 39829|34 DNAAF4| 7240 CCDC39| SMAD4|S 4089|409 R-HSA- Reactome MAD5|S 1 -1.75965 M1 1 0 6 Signaling by BMP -1.75965 3.952872 3.027291 24156 28 873 4 0.45819 0.22857 0|64750|9 -0.5178 0 197 0 0 -2.41795 18.44674 201451 Gene Sets MURF2|C 1851 HRDL1 GO 3280|562 HES1|PR GO:00971 1 -2.06199 M1 1 0 Biological 19 neuronal stem cell population maintenance -2.06199 4.812192 3.541801 24156 23 873 4 0.45819 0.22857 9|79648|2 OX1|MCP -0.72482 0 92 0 0 -3.73382 12.29782 50 Processes 59266 H1|ASPM GO 3280|397 HES1|LIF| GO:00721 1 -2.06199 M1 1 0 Biological 19 metanephric tubule development -2.06199 4.812192 3.541801 24156 23 873 4 0.45819 0.22857 6|10413|3 YAP1|SO -0.72482 0 118 0 0 -3.28677 7.905744 70 Processes 0812 X8 GO 3280|397 HES1|LIF| GO:00722 metanephric nephron epithelium 1 -2.06199 M1 1 0 Biological 19 -2.06199 4.812192 3.541801 24156 23 873 4 0.45819 0.22857 6|10413|3 YAP1|SO -0.72482 0 118 0 0 -3.28677 7.905744 43 development Processes 0812 X8 CHRNA1| GABRA2| 1134|255 GO GABRA3| GO:00052 extracellular ligand-gated ion channel 5|2556|25 1 -1.75964 M1 1 0 Molecular 21 -1.75964 2.617442 2.698296 24156 74 873 7 0.801833 0.301847 GABRA4| -0.5178 0 112 0 0 -3.34087 10.06186 30 activity 57|2565|2 Functions GABRG1| 890|2902 GRIA1|GR IN1 GO 3958|638 LGALS3|C GO:00716 positive regulation of mononuclear cell 1 -2.06199 M1 1 0 Biological 19 -2.06199 4.812192 3.541801 24156 23 873 4 0.45819 0.22857 7|196527| XCL12|AN -0.72482 0 152 0 0 -2.8845 27.6701 77 migration Processes 729230 O6|CCR2 GO 2902|228 GRIN1|NL GO:00435 1 -2.06199 M1 1 0 Biological 19 regulation of respiratory gaseous exchange -2.06199 4.812192 3.541801 24156 23 873 4 0.45819 0.22857 71|23178| GN1|PAS -0.72482 0 202 0 0 -2.32557 4.882959 76 Processes 57616 K|TSHZ3 AGTR2|C 186|947|1 D34|COM 312|1393| T|CRHBP| 2335|362 FN1|INHB 4|3976|64 A|LIF|SFR GO 22|7132|7 P1|TNFRS GO:00510 1 -2.06056 M1 1 0 Biological 19 negative regulation of secretion -2.06056 1.90442 2.76649 24156 247 873 17 1.947308 0.467671 133|1114 F1A|TNFR -0.72373 0 204 0 0 -2.30866 2.003265 48 Processes 1|28984|2 SF1B|IL1R 9091|941 APL1|RGC 21|11489 C|STXBP6 9|131450| |SYTL4|C1 729230 QTNF3|C D200R1|C ADORA2 A|CDK1|C 135|983|1 REB1|PRK 385|5563| GO AA2|PRO GO:00427 5629|609 1 -2.05207 M1 1 0 Biological 19 regulation of circadian rhythm -2.05207 2.406096 2.926704 24156 115 873 10 1.145475 0.360151 X1|RORA| -0.71809 0 185 0 0 -2.51915 2.406096 52 5|7153|10 Processes TOP2A|P 891|2287 PARGC1A 1|79723 |NLGN1|S UV39H2 CDK1|CR 983|1382| ABP2|CRE 1385|224 B1|FGF2|F 7|2307|23 OXS1|FN 35|2803|4 1|GOLGA 208|4886| 4|MEF2C| 4916|560 NPY1R|N GO GO:00486 0|5629|63 TRK3|MA 1 -2.05204 M1 1 0 Biological 19 regulation of developmental growth -2.05204 1.739264 2.697623 24156 350 873 22 2.520046 0.530463 -0.71809 0 29 0 0 -6.42481 3.074456 38 87|6422|7 PK11|PRO Processes 093|7852| X1|CXCL1 9423|972 2|SFRP1|T 3|10413|2 LL2|CXCR 3414|151 4|NTN1|S 835|2197 EMA3E|Y 70 AP1|ZFP M2|CPNE 186|2247| AGTR2|F GO 3280|408 GF2|HES1 GO:00606 1 -2.05201 M1 1 0 Biological 19 ureteric bud morphogenesis -2.05201 2.979857 3.094955 24156 65 873 7 0.801833 0.301847 9|5228|10 |SMAD4|P -0.71809 0 10 0 0 -10.1376 3.952872 75 Processes 736|3081 GF|SIX2|S 2 OX8 CORUM:2 BRCA1-BARD1-BACH1-DNA damage BARD1|B 1 -1.75049 M1 1 0 CORUM 33 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 580|672 -0.5178 0 70 0 0 -4.32747 27.6701 817 complex I RCA1 CDH5|EC 1003|189 T2|CLDN1 GO 4|5010|51 GO:01201 1|PECAM 1 -2.05201 M1 1 0 Biological 19 tight junction organization -2.05201 2.979857 3.094955 24156 65 873 7 0.801833 0.301847 75|10266| -0.71809 0 132 0 0 -3.08964 3.175258 93 1|RAMP2| Processes 84612|10 PARD6B| 0506658 OCLN 2324|290 FLT4|GRI GO 2|6939|22 N1|TCF15 GO:00075 1 -2.05201 M1 1 0 Biological 19 respiratory gaseous exchange -2.05201 2.979857 3.094955 24156 65 873 7 0.801833 0.301847 871|2317 |NLGN1|P -0.71809 0 202 0 0 -2.32557 4.882959 85 Processes 8|57616|1 ASK|TSHZ 47372 3|CCBE1 GO GO:00045 5167|516 ENPP1|E 1 -1.75049 M1 1 0 Molecular 21 phosphodiesterase I activity -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 73 0 0 -4.32747 27.6701 28 9 NPP3 Functions GO GO:00506 3'-phosphoadenosine 5'-phosphosulfate 5167|513 ENPP1|C 1 -1.75049 M1 1 0 Molecular 21 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 73 0 0 -4.32747 27.6701 56 binding 63 HST15 Functions 2535|328 FZD2|HES GO 0|4610|49 1|MYCL|N GO:00424 1 -2.05201 M1 1 0 Biological 19 mechanoreceptor differentiation -2.05201 2.979857 3.094955 24156 65 873 7 0.801833 0.301847 16|9497|6 TRK3|SLC -0.71809 0 240 1 1 -2.05201 6.917526 90 Processes 4072|117 4A7|CDH 531 23|TMC1 AGTR2|F 186|2247| GF2|MEF2 GO 4208|691 GO:00435 negative regulation of blood vessel C|TBXA2R 1 -2.05184 M1 1 0 Biological 19 -2.05184 2.73285 3.024903 24156 81 873 8 0.91638 0.322501 5|7057|28 -0.71809 0 15 0 0 -9.08083 2.73285 37 endothelial cell migration |THBS1|R Processes 984|5456 GCC|DLL4 7|79812 |MMRN2 BRCA1|C 672|835|9 ASP2|CD GO 83|6790|7 GO:00711 K1|AURK 1 -2.05184 M1 1 0 Biological 19 positive regulation of cell cycle arrest -2.05184 2.73285 3.024903 24156 81 873 8 0.91638 0.322501 029|2898 -0.71809 0 30 0 0 -6.32789 4.035223 58 A|TFDP2| Processes 4|51512|1 RGCC|GT 44455 SE1|E2F7 CORUM:3 CDK1|CC 1 -1.75049 M1 1 0 CORUM 33 Cell cycle kinase complex CDC2 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 983|9133 -0.5178 0 110 0 0 -3.35124 18.44674 10 NB2 CENPE|CE 1062|106 NPF|CREB 3|1385|24 1|CENPI| 91|3070|4 HELLS|M 175|5931| CM6|RBB 8208|831 P7|CHAF1 GO 8|8357|23 B|CDC45| GO:00718 1 -2.05084 M1 1 0 Biological 19 protein-DNA complex subunit organization -2.05084 1.825458 2.728817 24156 288 873 19 2.176403 0.493838 421|5535 H3C10|IT -0.71744 0 31 0 0 -6.31644 12.57732 24 Processes 5|55506|5 GB3BP|HJ 5839|570 URP|MAC 82|79003| ROH2A2| 91687|40 CENPN|K 1541|653 NL1|MIS1 604 2|CENPL| CENPP|H GO GO:00321 Cellular BIRC5|AU 1 -1.75049 M1 1 0 20 chromosome passenger complex -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 332|6790 -0.5178 0 128 0 0 -3.12886 18.44674 33 Compone RKA nts GO GO:00351 5563|679 PRKAA2| 1 -1.75049 M1 1 0 Molecular 21 histone serine kinase activity -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 128 0 0 -3.12886 18.44674 74 0 AURKA Functions AGTR2|SE 186|5270| GO RPINE2|P GO:00216 5629|609 1 -2.04646 M1 1 0 Biological 19 cerebellar cortex development -2.04646 3.320412 3.180378 24156 50 873 6 0.687285 0.279617 ROX1|RO -0.71374 0 92 0 0 -3.73382 12.29782 95 5|9928|85 Processes RA|KIF14| 442 KNDC1 CORUM:1 4998|499 ORC1|OR 1 -1.75049 M1 1 0 CORUM 33 ORC complex (origin recognition complex) -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 138 0 0 -3.01725 11.06804 031 9 C2 CORUM:1 4998|499 ORC1|OR 1 -1.75049 M1 1 0 CORUM 33 ORC complex (origin recognition complex) -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 138 0 0 -3.01725 11.06804 033 9 C2 CORUM:3 4998|499 ORC1|OR 1 -1.75049 M1 1 0 CORUM 33 ORC complex (origin recognition complex) -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 138 0 0 -3.01725 11.06804 89 9 C2 R-HSA- Reactome Assembly of the ORC complex at the origin 4998|499 ORC1|OR 1 -1.75049 M1 1 0 6 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 138 0 0 -3.01725 11.06804 68616 Gene Sets of replication 9 C2 CD34|PD 947|5156| GO GFRA|SER GO:19000 5270|705 1 -2.04646 M1 1 0 Biological 19 negative regulation of hemostasis -2.04646 3.320412 3.180378 24156 50 873 6 0.687285 0.279617 PINE2|TH -0.71374 0 108 0 0 -3.3802 5.825285 47 6|7057|17 Processes BD|THBS1 0692 |ADAMTS GO GO:00312 Cellular FAS|FAD 1 -1.75049 M1 1 0 20 CD95 death-inducing signaling complex -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 355|8772 -0.5178 0 141 0 0 -2.97821 18.44674 65 Compone D nts AGTR2|C 186|1003| DH5|DUS 1849|367 P7|ITGA1| 2|3673|39 ITGA2|LG 58|4208|5 ALS3|MEF 783|5795| 2C|PTPN1 8483|910 3|PTPRJ|C 4|9814|10 ILP|RGN|S 454|1107 FI1|TAB1| GO 2|22843|2 DUSP14|P GO:00163 1 -2.04396 M1 1 0 Biological 19 dephosphorylation -2.04396 1.617459 2.64304 24156 479 873 28 3.207331 0.596329 3504|271 PM1E|RI -0.71172 0 199 0 0 -2.40034 2.76701 11 Processes 43|51559| MBP2|PA 55125|57 LD1|NT5 082|5771 DC3|CEP1 8|84618|8 92|KNL1| 4687|848 PPP4R4|N 67|84930| T5C1A|PP 93492|15 P1R9B|PT 7313|392 PN5|MAS 617 TL|TPTE2| CDCA2|EL BMP7|CD 655|983|1 K1|CYP1B 545|1894| 1|ECT2|G 2882|423 PX7|MET| 3|5156|51 PDGFRA| 79|5563|5 PENK|PRK GO 587|7296| AA2|PRK GO:00345 1 -2.04376 M1 1 0 Biological 19 cellular response to oxidative stress -2.04376 1.790945 2.709567 24156 309 873 20 2.290951 0.50637 9104|983 D1|TXNR -0.71172 0 120 0 0 -3.26614 6.385408 99 Processes 3|10276|1 D1|RGN| 0516|105 MELK|NE 87|10891| T1|FBLN5| 30001|79 TXNRD2| 912|1408 PPARGC1 09 A|ERO1A| PYROXD1 ALK|BMP 238|655|1 7|CRABP2 382|2335| |FN1|GOL 2803|367 GA4|ITGA 3|3706|49 2|ITPKA|N 16|5587|6 TRK3|PRK 387|6498| D1|CXCL1 7074|785 2|SKIL|TIA GO GO:00313 positive regulation of cell projection 2|9423|96 M1|CXCR 1 -2.04201 M1 1 0 Biological 19 -2.04201 1.689777 2.669597 24156 393 873 24 2.749141 0.553399 -0.71099 0 29 0 0 -6.42481 3.074456 46 organization 62|11141| 4|NTN1|C Processes 22871|23 EP135|IL1 433|2706 RAPL1|NL 3|54443|5 GN1|RHO 5835|151 Q|ANKRD 835|2850 1|ANLN|C 16|10050 ENPJ|CPN 6658 E9|ALKAL 2|OCLN FN1|GOL GA4|NTR 2335|280 K3|CXCL1 3|4916|63 2|SH3GL2 87|6456|6 GO |AURKA|T GO:19901 790|7074| 1 -2.02641 M1 1 0 Biological 19 neuron projection extension -2.02641 2.103575 2.804279 24156 171 873 13 1.489118 0.40992 IAM1|CX -0.69573 0 29 0 0 -6.42481 3.074456 38 7852|942 Processes CR4|NTN 3|9723|10 1|SEMA3 631|5443 E|POSTN| 7|151835 SEMA5B| CPNE9 AGTR2|C 186|1021| DK6|CREB GO 1385|233 GO:00481 1|FN1|PD 1 -2.02082 M1 1 0 Biological 19 regulation of fibroblast proliferation -2.02082 2.699522 2.985045 24156 82 873 8 0.91638 0.322501 5|5156|64 -0.69149 0 242 1 1 -2.02082 2.699522 45 GFRA|SFR Processes 22|56034| P1|PDGF 80169 C|CTC1 186|2247| AGTR2|F GO 3280|408 GF2|HES1 GO:00721 1 -2.0167 M1 1 0 Biological 19 mesonephric tubule morphogenesis -2.0167 2.934708 3.047615 24156 66 873 7 0.801833 0.301847 9|5228|10 |SMAD4|P -0.68771 0 10 0 0 -10.1376 3.952872 71 Processes 736|3081 GF|SIX2|S 2 OX8 CMKLR1| 1240|138 CREB1|HE 5|3280|39 S1|LAMB 14|5167|6 3|ENPP1| 095|6422| RORA|SF GO 10891|23 RP1|PPAR GO:00454 1 -2.01194 M1 1 0 Biological 19 fat cell differentiation -2.01194 1.924877 2.729002 24156 230 873 16 1.832761 0.453972 414|3000 GC1A|ZFP -0.68329 0 243 1 1 -2.01194 2.943628 44 Processes 1|30812|6 M2|ERO1 4641|114 A|SOX8|E 899|1489 BF2|C1QT 79|25299 NF3|GLIS 5|284273 1|FNDC5| ZADH2 R-HSA- Reactome 4233|669 MET|SPIN 1 -1.75049 M1 1 0 6 MET Receptor Activation -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 193 0 0 -2.41795 18.44674 6806942 Gene Sets 2 T1 CENPI|HE 2491|307 LLS|RBBP 0|5931|82 7|CHAF1B 08|8357|2 |H3C10|IT 3421|553 GB3BP|HJ GO GO:00063 55|55506| URP|MAC 1 -2.00909 M1 1 0 Biological 19 chromatin assembly or disassembly -2.00909 2.028175 2.762398 24156 191 873 14 1.603666 0.425147 -0.68077 0 31 0 0 -6.31644 12.57732 33 55839|57 ROH2A2| Processes 082|7972 CENPN|K 3|91687|4 NL1|SUV3 01541|65 9H2|CEN 3604 PL|CENPP |H3C13 CCN2|LO 1490|401 GO XL2|PTHL GO:00323 7|5744|10 1 -2.00524 M1 1 0 Biological 19 regulation of chondrocyte differentiation -2.00524 3.255306 3.121966 24156 51 873 6 0.687285 0.279617 H|SIX2|PK -0.67726 0 53 0 0 -4.98746 13.83505 30 736|9146 Processes DCC|RFL 1|359845 NB AGTR2|A HR|BMP7| BRCA1|C 186|196|6 REB1|CRH 55|672|13 BP|CYP24 85|1393|1 A1|DNMT 591|1789| 3B|ESRRB| 2103|301 H2AZ1|IN 5|3624|36 HBA|ITGA 73|4208|4 2|MEF2C| 916|5179| NTRK3|PE 5563|609 NK|PRKA GO 5|6258|64 A2|RORA| GO:00713 1 -1.99953 M1 1 0 Biological 19 cellular response to lipid -1.99953 1.527246 2.566797 24156 616 873 34 3.894616 0.654786 22|6915|7 RXRG|SFR -0.67222 0 150 0 0 -2.88568 1.913358 96 Processes 133|7520| P1|TBXA2 8767|885 R|TNFRSF 4|10413|1 1B|XRCC5 0891|270 |RIPK2|AL 63|54997| DH1A2|Y 56937|81 AP1|PPAR 930|8468 GC1A|AN 7|85315|1 KRD1|TES 61582|33 C|PMEPA 9479 1|KIF18A| PPP1R9B| PAQR8|D NAAF4|B GO 2247|423 FGF2|MET GO:20010 1 -1.99519 M1 1 0 Biological 19 regulation of endothelial cell chemotaxis -1.99519 4.611684 3.427756 24156 24 873 4 0.45819 0.22857 3|5587|70 |PRKD1|T -0.67008 0 232 0 0 -2.12027 5.534021 26 Processes 57 HBS1 2048|103 EPHB2|C GO GO:20002 positive regulation of signaling receptor 69|23237| ACNG2|A 1 -1.99205 M1 1 0 Biological 19 -1.99205 3.739203 3.228766 24156 37 873 5 0.572738 0.255402 -0.67008 0 45 0 0 -5.5147 9.223368 73 activity 54892|72 RC|NCAP Processes 9230 G2|CCR2 GO GO:00435 1062|727 CENPE|TT 1 -1.75049 M1 1 0 Molecular 21 kinetochore binding -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 217 0 0 -2.20452 9.223368 15 2 K Functions ACTN1|A 87|88|282 CTN2|GP GO 4|3673|57 M6B|ITGA GO:00070 1 -1.99036 M1 1 0 Biological 19 cell-substrate adherens junction assembly -1.99036 2.666998 2.945779 24156 83 873 8 0.91638 0.322501 95|6422|7 2|PTPRJ|S -0.67008 0 39 0 0 -5.93077 3.633448 45 Processes 057|2299 FRP1|THB 8 S1|LIMCH 1 ACTN1|A 87|88|282 CTN2|GP GO 4|3673|57 M6B|ITGA GO:00480 1 -1.99036 M1 1 0 Biological 19 focal adhesion assembly -1.99036 2.666998 2.945779 24156 83 873 8 0.91638 0.322501 95|6422|7 2|PTPRJ|S -0.67008 0 39 0 0 -5.93077 3.633448 41 Processes 057|2299 FRP1|THB 8 S1|LIMCH 1 AGTR2|C 186|1021| DK6|CREB GO 1385|233 GO:00481 1|FN1|PD 1 -1.99036 M1 1 0 Biological 19 fibroblast proliferation -1.99036 2.666998 2.945779 24156 83 873 8 0.91638 0.322501 5|5156|64 -0.67008 0 242 0 0 -2.02082 2.699522 44 GFRA|SFR Processes 22|56034| P1|PDGF 80169 C|CTC1 CORUM:5 4999|752 ORC2|XR 1 -1.75049 M1 1 0 CORUM 33 Ku-ORC complex -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 276 1 1 -1.75049 9.223368 251 0 CC5 CNN3|TN 1266|713 NT2|TNN GO 9|7140|86 T3|DYNLL GO:00434 1 -1.99036 M1 1 0 Biological 19 regulation of ATPase activity -1.99036 2.666998 2.945779 24156 83 873 8 0.91638 0.322501 55|9104|2 1|RGN|N -0.67008 0 245 1 1 -1.99036 5.188144 62 Processes 3397|291 CAPH|UH 28|55112 RF1|WDR 60 GO GO:00487 positive regulation of astrocyte 3280|397 HES1|LIF| 1 -1.98904 M1 1 0 Biological 19 -1.98904 6.385408 3.760849 24156 13 873 3 0.343643 0.198061 -0.67008 0 56 0 0 -4.84716 6.385408 11 differentiation 6|5270 SERPINE2 Processes GO GO:00091 1854|516 DUT|ENP 1 -1.98904 M1 1 0 Biological 19 nucleoside triphosphate catabolic process -1.98904 6.385408 3.760849 24156 13 873 3 0.343643 0.198061 -0.67008 0 73 0 0 -4.32747 27.6701 43 7|5169 P1|ENPP3 Processes GO GO:00988 Cellular extrinsic component of postsynaptic 3838|707 KPNA2|TI 1 -1.75049 M1 1 0 20 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 278 0 0 -1.75049 9.223368 92 Compone specialization membrane 4 AM1 nts R-HSA- Reactome 3838|436 KPNA2|M 1 -1.75049 M1 1 0 6 Sensing of DNA Double Strand Breaks -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 278 1 1 -1.75049 9.223368 5693548 Gene Sets 1 RE11 CORUM:2 6767|820 ST13|CHA 1 -1.75049 M1 1 0 CORUM 33 ASF1-histone containing complex -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 279 1 1 -1.75049 9.223368 236 8 F1B GO LDLRAD4| GO:00071 753|4089| 1 -1.98904 M1 1 0 Biological 19 SMAD protein complex assembly -1.98904 6.385408 3.760849 24156 13 873 3 0.343643 0.198061 SMAD4|P -0.67008 0 84 0 0 -3.88473 11.06804 83 56937 Processes MEPA1 GO GO:20001 regulation of removal of superoxide 655|9104| BMP7|RG 1 -1.98904 M1 1 0 Biological 19 -1.98904 6.385408 3.760849 24156 13 873 3 0.343643 0.198061 -0.67008 0 120 0 0 -3.26614 6.385408 21 radicals 10516 N|FBLN5 Processes GO GO:00091 2618|547 GART|PP 1 -1.98904 M1 1 0 Biological 19 purine nucleobase biosynthetic process -1.98904 6.385408 3.760849 24156 13 873 3 0.343643 0.198061 -0.67008 0 135 0 0 -3.06206 13.83505 13 1|10606 AT|PAICS Processes CREB1|D 1385|184 USP7|ME 9|4208|42 R-HSA- Reactome TRAF6 mediated induction of NFkB and F2C|MAP 1 -1.73913 M1 1 0 6 -1.73913 2.406096 2.616472 24156 92 873 8 0.91638 0.322501 14|5600|8 -0.50753 0 255 0 0 -1.94359 11.06804 975138 Gene Sets MAP kinases upon TLR7/8 or 9 activation 3K1|MAP 767|1045 K11|RIPK2 4|51284 |TAB1|TLR GO GO:00460 2618|547 GART|PP 1 -1.98904 M1 1 0 Biological 19 IMP metabolic process -1.98904 6.385408 3.760849 24156 13 873 3 0.343643 0.198061 -0.67008 0 135 0 0 -3.06206 13.83505 40 1|10606 AT|PAICS Processes GO ITGA2|CX GO:00509 detection of mechanical stimulus involved 3673|638 1 -1.98904 M1 1 0 Biological 19 -1.98904 6.385408 3.760849 24156 13 873 3 0.343643 0.198061 CL12|CXC -0.67008 0 151 0 0 -2.8845 27.6701 66 in sensory perception of pain 7|7852 Processes R4 FGF2|VEG 2247|227 FD|FLT4|G 7|2324|29 RIN1|MET 02|4233|5 |PDGFRA| 156|5228| PGF|PLA2 KEGG 5321|707 G4A|TIA 1 -1.73433 hsa04014 M1 1 0 24 Ras signaling pathway -1.73433 1.828421 2.428247 24156 227 873 15 1.718213 0.439813 -0.50405 0 60 0 0 -4.57507 9.223368 Pathway 4|10125|2 M1|RASG 2800|228 RP1|RRAS 21|25780| 2|RASA3| 56034|91 RASGRP3| 860 PDGFC|C ALML4 Transcription of E2F targets under negative R-HSA- Reactome 983|7029| CDK1|TFD 1 -1.73216 M1 1 0 6 control by p107 (RBL1) and p130 (RBL2) in -1.73216 5.188144 3.244921 24156 16 873 3 0.343643 0.198061 -0.50405 0 109 0 0 -3.37978 5.929308 1362300 Gene Sets 286826 P2|LIN9 complex with H GO 7054|260 TH|MOX GO:00424 1 -1.98904 M1 1 0 Biological 19 norepinephrine metabolic process -1.98904 6.385408 3.760849 24156 13 873 3 0.343643 0.198061 02|28567 D1|RNF18 -0.67008 0 219 0 0 -2.20452 7.905744 15 Processes 1 0 GO DYNLL1| GO:20005 8655|548 1 -1.98904 M1 1 0 Biological 19 regulation of microtubule motor activity -1.98904 6.385408 3.760849 24156 13 873 3 0.343643 0.198061 NDE1|WD -0.67008 0 246 1 1 -1.98904 9.223368 74 20|55112 Processes R60 GO AGTR2|N GO:00513 regulation of neurotrophin TRK receptor 186|4916| 1 -1.98904 M1 1 0 Biological 19 -1.98904 6.385408 3.760849 24156 13 873 3 0.343643 0.198061 TRK3|DO -0.67008 0 247 1 1 -1.98904 6.385408 86 signaling pathway 55816 Processes K5 GO GO:00433 3075|367 CFH|ITGA 1 -1.73216 M1 1 0 Molecular 21 heparan sulfate proteoglycan binding -1.73216 5.188144 3.244921 24156 16 873 3 0.343643 0.198061 -0.50405 0 162 0 0 -2.77297 5.188144 95 3|10468 2|FST Functions ADORA2 A|ALOX5| CD34|CD 135|240|9 H5|FABP7 47|1003|2 |FGF2|GP 173|2247| R17|GRIN 2840|290 1|PDGFR 2|5156|51 A|ENPP3| 69|5270|6 SERPINE2 GO GO:00321 negative regulation of response to external 095|7056| |RORA|TH 1 -1.98735 M1 1 0 Biological 19 -1.98735 1.692586 2.620915 24156 376 873 23 2.634593 0.542066 -0.66895 0 108 0 0 -3.3802 5.825285 02 stimulus 7057|713 BD|THBS1 Processes 0|7132|71 |TNFAIP6| 33|9723|5 TNFRSF1 6963|791 A|TNFRSF 48|11489 1B|SEMA 9|131450| 3E|RGMA| 170692 MMP28|C 1QTNF3| CD200R1| ADAMTS CALB2|C DH5|CMK 794|1003| LR1|DRD5 1240|181 |EDN2|ED 6|1907|19 N3|FGF2| 08|2247|2 GPR17|LP 840|2846| AR4|GRIA 2890|290 1|GRIN1| 2|3357|51 HTR2B|P 56|6387|6 GO DGFRA|C GO:00550 869|6915| 1 -1.98725 M1 1 0 Biological 19 calcium ion homeostasis -1.98725 1.60075 2.585175 24156 484 873 28 3.207331 0.596329 XCL12|TA -0.66895 0 94 0 0 -3.67332 2.548562 74 7223|785 Processes CR1|TBXA 2|9104|10 2R|TRPC4 590|1134 |CXCR4|R 6|22821|3 GN|SCGN 0001|515 |SYNPO|R 54|54757| ASA3|ER 55013|64 O1A|ACK 072|7292 R4|FAM2 30 0A|MCUB |CDH23|C 1462|223 VCAN|GP GO 9|2247|31 C4|FGF2| GO:00060 1 -1.98214 M1 1 0 Biological 19 aminoglycan catabolic process -1.98214 2.890906 3.00116 24156 67 873 7 0.801833 0.301847 61|4060|4 HMMR|L -0.66492 0 96 0 0 -3.66151 10.37629 26 Processes 969|1108 UM|OGN| 1 KERA CMKLR1| 1240|190 EDN2|ED 7|1908|22 N3|VEGF 77|3269|3 D|HRH1|I 672|3958| TGA1|LG GO GO:00975 5175|522 ALS3|PEC 1 -1.98158 M1 1 0 Biological 19 myeloid leukocyte migration -1.98158 1.95779 2.712259 24156 212 873 15 1.718213 0.439813 -0.66492 0 42 0 0 -5.75682 3.654542 29 8|6387|70 AM1|PGF| Processes 57|79148| CXCL12|T 131450|1 HBS1|MM 96527|72 P28|CD20 9230 0R1|ANO 6|CCR2 CREB1|NT 1385|491 RK3|PDGF 6|5156|55 RA|PRKA 63|6422|6 A2|SFRP1| 935|7520| ZEB1|XRC GO GO:00712 8854|104 C5|ALDH 1 -1.98158 M1 1 0 Biological 19 cellular response to acid chemical -1.98158 1.95779 2.712259 24156 212 873 15 1.718213 0.439813 -0.66492 0 165 0 0 -2.70943 2.669922 29 13|10891| 1A2|YAP1 Processes 54997|56 |PPARGC 034|1436 1A|TESC| 86|33947 PDGFC|SE 9|652968 SN3|BRIN P3|CAST ACTC1|A 70|88|375 CTN2|KC 9|3762|46 NJ2|KCNJ GO GO:00702 32|7135|7 5|MYL1|T 1 -1.97717 M1 1 0 Biological 19 actin-mediated cell contraction -1.97717 2.344924 2.835834 24156 118 873 10 1.145475 0.360151 -0.66116 0 61 0 0 -4.53228 18.44674 52 136|7139| NNI1|TN Processes 7140|229 NI2|TNNT 98 2|TNNT3| LIMCH1 CDH5|SM 1003|408 AD4|MET| 9|4233|51 PECAM1| GO GO:00454 75|5629|6 PROX1|ZE 1 -1.97717 M1 1 0 Biological 19 endothelial cell differentiation -1.97717 2.344924 2.835834 24156 118 873 10 1.145475 0.360151 -0.66116 0 127 0 0 -3.17736 9.223368 46 935|7132| B1|TNFRS Processes 7852|260 F1A|CXCR 84|64102 4|ARHGE F26|TNM ACTN2|M GO 88|4632|1 GO:00083 YL1|NEBL| 1 -1.72461 M1 1 0 Molecular 21 structural constituent of muscle -1.72461 3.217454 2.818087 24156 43 873 5 0.572738 0.255402 0529|272 -0.4981 0 48 0 0 -5.29557 3.217454 07 PDLIM3| Functions 95|91624 NEXN ACTN1|A DORA2A| 87|135|94 CD34|EN 7|954|103 TPD2|CD 6|1131|13 O1|CHRM 85|2048|2 3|CREB1|E 157|2313| PHB2|F8|F 2814|367 LI1|GP5|IT 3|3690|42 GA2|ITGB 33|4883|5 GO 3|MET|NP GO:00508 156|5270| 1 -1.97588 M1 1 0 Biological 19 regulation of body fluid levels -1.97588 1.582708 2.567673 24156 507 873 29 3.321879 0.606525 R3|PDGFR -0.6602 0 108 0 0 -3.3802 5.825285 78 5471|691 Processes A|SERPIN 5|7056|70 E2|PPAT|T 57|7980|8 BXA2R|T 357|2341 HBD|THB 4|50808|1 S1|TFPI2| 39189|17 H3C10|ZF 0692|196 PM2|AK3| 527|6536 DGKK|AD 04 AMTS18| ANO6|H3 186|1046 AGTR2|FS GO GO:00305 8|27123|1 T|DKK2|W 1 -1.72461 M1 1 0 Molecular 21 receptor inhibitor activity -1.72461 3.217454 2.818087 24156 43 873 5 0.572738 0.255402 -0.4981 0 205 0 0 -2.28131 4.19244 47 17166|12 FIKKN1|W Functions 4857 FIKKN2 ADORA2 A|AGTR2| 135|186|2 SLC25A4| 91|580|94 BARD1|C 7|983|139 D34|CDK 3|1894|20 1|CRHBP| 40|2335|3 ECT2|STO 357|4155| M|FN1|HT 5116|517 R2B|MBP| 4|5600|64 PCNT|PD 22|7074|7 ZK1|MAP 133|8111| K11|SFRP 8767|932 1|TIAM1| GO 4|9585|96 TNFRSF1 GO:00900 1 -1.97435 M1 1 0 Biological 19 regulation of peptide transport -1.97435 1.465966 2.518845 24156 755 873 40 4.581901 0.707671 48|10125| B|GPR68| -0.659 0 133 0 0 -3.08066 2.143459 87 Processes 10631|23 RIPK2|HM 086|2317 GN3|KIF2 8|23379|2 0B|GCC2| 7063|289 RASGRP1| 84|29969| POSTN|E 51512|51 XPH5|PAS 715|7967 K|ICE1|AN 9|80184|8 KRD1|RG 4455|914 CC|MDFI 61|94121| C|GTSE1| 114899|1 RAB23|VT 31450 CN1|CEP 290|EFCA B7|PKDC DNMT3B| 1789|301 H2AZ1|H 5|3070|59 ELLS|RBB 31|8318|8 P7|CDC45 GO GO:00458 negative regulation of gene expression, 357|8726| |H3C10|E 1 -1.96848 M1 1 0 Biological 19 -1.96848 2.142202 2.762391 24156 155 873 12 1.37457 0.394068 -0.65367 0 248 1 1 -1.96848 2.142202 14 epigenetic 55051|55 ED|NRDE Processes 183|5519 2|RIF1|RE 6|55506|6 SF1|MAC 53604 ROH2A2| H3C13 CREB1|D 1385|184 USP7|ME 9|4208|42 R-HSA- Reactome F2C|MAP 1 -1.71354 M1 1 0 6 Toll Like Receptor 7/8 (TLR7/8) Cascade -1.71354 2.380224 2.582304 24156 93 873 8 0.91638 0.322501 14|5600|8 -0.48784 0 255 0 0 -1.94359 11.06804 168181 Gene Sets 3K1|MAP 767|1045 K11|RIPK2 4|51284 |TAB1|TLR CREB1|D 1385|184 USP7|ME 9|4208|42 R-HSA- Reactome MyD88 dependent cascade initiated on F2C|MAP 1 -1.71354 M1 1 0 6 -1.71354 2.380224 2.582304 24156 93 873 8 0.91638 0.322501 14|5600|8 -0.48784 0 255 0 0 -1.94359 11.06804 975155 Gene Sets endosome 3K1|MAP 767|1045 K11|RIPK2 4|51284 |TAB1|TLR FBN1|SFR 2200|642 GO P1|SKIL|S GO:00305 negative regulation of BMP signaling 2|6498|64 1 -1.96512 M1 1 0 Biological 19 -1.96512 3.192704 3.064985 24156 52 873 6 0.687285 0.279617 MURF2|C -0.65173 0 55 0 0 -4.87217 18.44674 14 pathway 750|9185 Processes HRDL1|V 1|375567 WC2 983|2247| CDK1|FGF GO GO:00604 4208|562 2|MEF2C| 1 -1.96512 M1 1 0 Biological 19 positive regulation of heart growth -1.96512 3.192704 3.064985 24156 52 873 6 0.687285 0.279617 -0.65173 0 117 0 0 -3.28848 6.510612 21 9|10413|2 PROX1|Y Processes 3414 AP1|ZFP ADORA2 A|XIAP|BI 135|331|3 RC5|C4A| 32|720|12 COL7A1|S 94|5270|6 ERPINE2| 692|7057| SPINT1|T GO 7078|707 GO:00109 negative regulation of endopeptidase HBS1|TIM 1 -1.96344 M1 1 0 Biological 19 -1.96344 1.859256 2.660405 24156 253 873 17 1.947308 0.467671 9|7980|92 -0.65038 0 116 0 0 -3.2998 2.23146 51 activity P3|TIMP4| Processes 32|55031| TFPI2|PTT 79444|80 G1|USP47 760|1171 |BIRC7|ITI 66|12485 H5|WFIKK 7 N1|WFIKK N2 CDK1|CR 983|1385| EB1|FGF2| 2247|408 GO SMAD4| GO:00550 regulation of cardiac muscle tissue 9|4208|56 1 -1.96184 M1 1 0 Biological 19 -1.96184 2.465653 2.858119 24156 101 873 9 1.030928 0.341867 MEF2C|M -0.64976 0 117 0 0 -3.28848 6.510612 24 development 00|10413| Processes APK11|YA 23414|93 P1|ZFPM 649 2|MYOCD PRDM1|H 639|3280| ES1|LTBP 4052|562 GO 1|PROX1| GO:00608 9|10454|1 1 -1.96184 M1 1 0 Biological 19 artery development -1.96184 2.465653 2.858119 24156 101 873 9 1.030928 0.341867 TAB1|AD -0.64976 0 154 0 0 -2.86448 3.797857 40 1174|545 Processes AMTS6|D 67|93649| LL4|MYO 144165 CD|PRICK 1003|423 CDH5|ME 3|22974|2 T|TPX2|C GO 6586|571 GO:00311 regulation of microtubule polymerization or KAP2|TRI 1 -1.96045 M1 1 0 Biological 19 -1.96045 2.635248 2.907089 24156 84 873 8 0.91638 0.322501 59|22115 -0.64869 0 40 0 0 -5.92255 5.29853 10 depolymerization M54|SKA Processes 0|246176| 3|GAS2L2 10050665 |OCLN 8 PRDM1|C 639|1312| OMT|CRH 1393|367 BP|ITGA2| 3|3976|43 LIF|MMP7 GO 16|5125|5 GO:00075 |PCSK5|P 1 -1.95348 M1 1 0 Biological 19 female pregnancy -1.95348 1.996812 2.699253 24156 194 873 14 1.603666 0.425147 228|5471| -0.64241 0 250 1 1 -1.95348 1.996812 65 GF|PPAT| Processes 5744|705 PTHLH|T 6|10266|1 HBD|RAM 0991|647 P2|SLC38 50 A3|SMUR GO 1490|369 CCN2|ITG GO:00055 1 -1.70748 M1 1 0 Molecular 21 insulin-like growth factor binding -1.70748 3.816566 2.938722 24156 29 873 4 0.45819 0.22857 0|3691|11 B3|ITGB4| -0.48577 0 111 0 0 -3.35124 18.44674 20 Functions 082 ESM1 ESRRB|EN 2103|516 PP1|PMAI 7|5366|60 P1|RORA| GO 95|9104|1 GO:00109 RGN|PPA 1 -1.95287 M1 1 0 Biological 19 regulation of glucose metabolic process -1.95287 2.325219 2.806158 24156 119 873 10 1.145475 0.360151 0891|231 -0.64241 0 251 1 1 -1.95287 3.29406 06 RGC1A|P Processes 78|57486| ASK|NLN| 85414|11 SLC45A3| 4899 C1QTNF3 ITGA1|PE 3672|517 CAM1|CX GO 5|6387|87 GO:00451 CL12|FAD 1 -1.94833 M1 1 0 Biological 19 cellular extravasation -1.94833 2.848393 2.955559 24156 68 873 7 0.801833 0.301847 72|58494| -0.63851 0 152 0 0 -2.8845 27.6701 23 D|JAM2|P Processes 83483|72 LVAP|CC 9230 R2 ACTN2|C CREB1 phosphorylation through NMDA R-HSA- Reactome 88|815|13 AMK2A|C 1 -1.70748 M1 1 0 6 receptor-mediated activation of RAS -1.70748 3.816566 2.938722 24156 29 873 4 0.45819 0.22857 -0.48577 0 164 0 0 -2.711 11.06804 442742 Gene Sets 85|2902 REB1|GRI signaling N1 AGTR2|F 186|2247| GF2|FLT4| 2324|369 ITGB3|ME 0|4208|42 F2C|MET| 33|5587|5 GO PRKD1|PR GO:00105 629|6915| 1 -1.9452 M1 1 0 Biological 19 regulation of endothelial cell migration -1.9452 1.891973 2.654923 24156 234 873 16 1.832761 0.453972 OX1|TBX -0.63699 0 15 0 0 -9.08083 2.73285 94 7057|289 Processes A2R|THBS 84|54567| 1|RGCC|D 57381|57 LL4|RHOJ| 608|7981 JCAD|MM 2|147372 RN2|CCB FAS|CDK 355|1030| N2B|COM 1312|159 T|CYP24A 1|5179|53 1|PENK|P 66|5563|5 MAIP1|PR GO 587|6422| KAA2|PRK GO:00316 1 -1.9452 M1 1 0 Biological 19 cellular response to nutrient levels -1.9452 1.891973 2.654923 24156 234 873 16 1.832761 0.453972 10631|10 D1|SFRP1 -0.63699 0 50 0 0 -5.25088 2.470545 69 Processes 991|8178 |POSTN|S 8|143686| LC38A3|N 154743|4 UAK2|SES 40738|65 N3|BMT2| 2968 MAP1LC3 C|CASTO CMKLR1| GO 1240|190 GO:00482 EDN2|LG 1 -1.94359 M1 1 0 Biological 19 macrophage chemotaxis -1.94359 3.640803 3.154629 24156 38 873 5 0.572738 0.255402 7|3958|70 -0.63699 0 42 0 0 -5.75682 3.654542 46 ALS3|THB Processes 57|79148 S1|MMP2 CDK1|FGF GO 983|2247| GO:00600 positive regulation of cardiac muscle cell 2|MEF2C| 1 -1.94359 M1 1 0 Biological 19 -1.94359 3.640803 3.154629 24156 38 873 5 0.572738 0.255402 4208|104 -0.63699 0 117 0 0 -3.28848 6.510612 45 proliferation YAP1|ZFP Processes 13|23414 M2 6387|877 CXCL12|F GO GO:20004 2|9547|58 ADD|CXC 1 -1.94359 M1 1 0 Biological 19 positive regulation of lymphocyte migration -1.94359 3.640803 3.154629 24156 38 873 5 0.572738 0.255402 -0.63699 0 152 0 0 -2.8845 27.6701 03 494|7292 L14|JAM2 Processes 30 |CCR2 ADORA2 GO 135|1003| GO:00431 A|CDH5| 1 -1.94359 M1 1 0 Biological 19 regulation of vascular permeability -1.94359 3.640803 3.154629 24156 38 873 5 0.572738 0.255402 3269|579 -0.63699 0 252 1 1 -1.94359 7.905744 14 HRH1|PT Processes 5|10266 PRJ|RAM CASP2|EC 835|1894| T2|TIAM1 7074|102 R-HSA- Reactome Cell death signalling via NRAGE, NRIF and |NET1|ITG 1 -1.70169 M1 1 0 6 -1.70169 2.548562 2.618173 24156 76 873 7 0.801833 0.301847 76|23421| -0.48076 0 95 0 0 -3.66655 2.902458 204998 Gene Sets NADE B3BP|AR 26084|50 HGEF26|A 650 RHGEF3 7057|108 THBS1|PP GO GO:19040 positive regulation of epithelial cell 91|28984| ARGC1A| 1 -1.94359 M1 1 0 Biological 19 -1.94359 3.640803 3.154629 24156 38 873 5 0.572738 0.255402 -0.63699 0 253 1 1 -1.94359 4.427216 37 apoptotic process 196527|6 RGCC|AN Processes 41700 O6|ECSC KIF11|MC 3832|417 M6|TNNT 5|7139|71 2|TNNT3| 40|7153|8 TOP2A|TT 458|9585| F2|KIF20B 9928|103 GO |KIF14|AB GO:00426 51|11104| 1 -1.69846 M1 1 0 Molecular 21 ATPase activity, coupled -1.69846 1.705691 2.349231 24156 292 873 18 2.061856 0.480948 CA8|KAT -0.47806 0 46 0 0 -5.44351 7.281606 23 26153|53 Functions NA1|KIF2 904|5482 6A|MYO3 1|55137|7 A|ERCC6L 9075|801 |FIGN|DS 19|81930| CC1|PIF1| 401720 KIF18A|FI 2247|328 FGF2|HES GO GO:00104 0|5081|85 1|PAX7|L 1 -1.94359 M1 1 0 Biological 19 regulation of cell fate commitment -1.94359 3.640803 3.154629 24156 38 873 5 0.572738 0.255402 -0.63699 0 254 1 1 -1.94359 3.640803 53 43|14897 MO4|GLIS Processes 9 1 CAMK2A| 815|2047| EPHB1|EP 2048|370 GO HB2|ITPK GO:00609 6|4208|70 1 -1.93542 M1 1 0 Biological 19 dendritic spine development -1.93542 2.44148 2.82492 24156 102 873 9 1.030928 0.341867 A|MEF2C| -0.62979 0 107 0 0 -3.41128 3.074456 96 74|22871| Processes TIAM1|NL 23237|26 GN1|ARC| 037 SIPA1L1 ACTC1|C 70|1490|3 CN2|KCN 759|3762| J2|KCNJ5| GO GO:00600 4090|463 SMAD5| 1 -1.93427 M1 1 0 Biological 19 cardiac muscle contraction -1.93427 2.205588 2.75018 24156 138 873 11 1.260023 0.37751 -0.62896 0 61 0 0 -4.53228 18.44674 48 2|7135|71 MYL1|TN Processes 36|7139|7 NI1|TNNI 140|7852 2|TNNT2| TNNT3|C AGTR2|C 186|1545| YP1B1|FG 2247|232 F2|FLT4|IT 4|3673|36 GA2|ITGB 90|4017|4 3|LOXL2| 208|4233| MEF2C|M 5175|558 ET|PECA GO GO:00106 7|5629|69 M1|PRKD 1 -1.93256 M1 1 0 Biological 19 epithelial cell migration -1.93256 1.695661 2.571431 24156 359 873 22 2.520046 0.530463 -0.62874 0 15 0 0 -9.08083 2.73285 31 15|7057|2 1|PROX1| Processes 8984|299 TBXA2R|T 41|54443| HBS1|RG 54567|57 CC|PKN3| 381|5760 ANLN|DL 8|79812|1 L4|RHOJ|J 47372 CAD|MM RN2|CCB ADORA2 B|AGTR2| 136|186|6 BRCA1|C 72|947|13 D34|CREB 85|1545|2 1|CYP1B1 324|3357| |FLT4|HTR 4060|415 2B|LUM| 5|4361|56 MBP|MRE 00|5795|6 11|MAPK GO 095|7057| GO:00018 11|PTPRJ| 1 -1.93223 M1 1 0 Biological 19 positive regulation of cytokine production -1.93223 1.59977 2.534319 24156 467 873 27 3.092784 0.58593 7520|876 -0.62874 0 133 0 0 -3.08066 2.143459 19 RORA|TH Processes 7|8772|10 BS1|XRCC 125|1063 5|RIPK2|F 1|23213|2 ADD|RAS 8984|512 GRP1|PO 84|79679| STN|SULF 114899|1 1|RGCC|T 47372|72 LR7|VTCN 9230 1|C1QTN F3|CCBE1| AGTR2|B 186|655|9 MP7|CD3 47|2239|2 4|GPC4|F 535|3280| ZD2|HES1 3976|408 |LIF|SMA GO 9|6422|70 GO:20000 D4|SFRP1 1 -1.93203 M1 1 0 Biological 19 regulation of animal organ morphogenesis -1.93203 1.844674 2.625682 24156 255 873 17 1.947308 0.467671 74|10736| -0.62874 0 10 0 0 -10.1376 3.952872 27 |TIAM1|SI Processes 23213|30 X2|SULF1| 812|6475 SOX8|SM 0|80326|1 URF2|WN 44165|34 T10A|PRI 0419 CKLE1|RS GO 655|1289| BMP7|CO GO:00459 negative regulation of embryonic 1 -1.93182 M1 1 0 Biological 19 -1.93182 4.427216 3.319824 24156 25 873 4 0.45819 0.22857 23213|44 L5A1|SUL -0.62874 0 153 0 0 -2.8845 27.6701 92 development Processes 1478 F1|NRARP MEF2C|C GO 4208|103 GO:20003 ACNG2|N 1 -1.93182 M1 1 0 Biological 19 regulation of AMPA receptor activity -1.93182 4.427216 3.319824 24156 25 873 4 0.45819 0.22857 69|22871| -0.62874 0 194 0 0 -2.41795 18.44674 11 LGN1|AR Processes 23237 C GO 7057|289 THBS1|RG GO:20003 positive regulation of endothelial cell 1 -1.93182 M1 1 0 Biological 19 -1.93182 4.427216 3.319824 24156 25 873 4 0.45819 0.22857 84|19652 CC|ANO6 -0.62874 0 253 0 0 -1.94359 4.427216 53 apoptotic process Processes 7|641700 |ECSCR CDKN2B| 1030|408 R-HSA- Reactome Transcriptional activity of SMAD4|S 1 -1.68494 M1 1 0 6 -1.68494 3.14433 2.756719 24156 44 873 5 0.572738 0.255402 9|6498|70 -0.46846 0 136 0 0 -3.0513 3.816566 2173793 Gene Sets SMAD2/SMAD3:SMAD4 heterotrimer KIL|TFDP2 29|64750 |SMURF2 ADORA2 A|AGTR2| LDLRAD4| 135|186|7 CYP1B1|F 53|1545|2 GF2|MEF2 247|4208| C|PTPRJ|C 5795|638 XCL12|SF 7|6422|69 RP1|TBXA 15|7057|7 2R|THBS1 GO 075|9104| GO:00400 |TIE1|RGN 1 -1.92995 M1 1 0 Biological 19 negative regulation of locomotion -1.92995 1.651946 2.552394 24156 402 873 24 2.749141 0.553399 9723|102 -0.62751 0 15 0 0 -9.08083 2.73285 13 |SEMA3E| Processes 06|10891| TRIM13|P 22998|23 PARGC1A 213|2898 |LIMCH1| 4|54567|7 SULF1|RG 9148|798 CC|DLL4| 12|93649| MMP28| 131450 MMRN2| MYOCD| CD200R1 ACTC1|C 70|1134|1 HRNA1|C 490|3759| CN2|KCN 3762|409 J2|KCNJ5| GO GO:00069 0|4632|71 SMAD5| 1 -1.92828 M1 1 0 Biological 19 striated muscle contraction -1.92828 2.043814 2.691201 24156 176 873 13 1.489118 0.40992 -0.62615 0 61 0 0 -4.53228 18.44674 41 35|7136|7 MYL1|TN Processes 139|7140| NI1|TNNI 7852|103 2|TNNT2| 24 TNNT3|C XCR4|KLH CD34|PD 947|5156| GO GFRA|SER GO:00508 5270|705 1 -1.92606 M1 1 0 Biological 19 negative regulation of coagulation -1.92606 3.132465 3.009368 24156 53 873 6 0.687285 0.279617 PINE2|TH -0.62558 0 108 0 0 -3.3802 5.825285 19 6|7057|17 Processes BD|THBS1 0692 |ADAMTS CCND2|C 894|1021| R-HSA- Reactome DK6|CDK 1 -1.68494 M1 1 0 6 Cyclin D associated events in G1 -1.68494 3.14433 2.756719 24156 44 873 5 0.572738 0.255402 1030|187 -0.46846 0 275 0 0 -1.76975 3.14433 69231 Gene Sets N2B|E2F2 0|7029 |TFDP2 CCND2|C 894|1021| R-HSA- Reactome DK6|CDK 1 -1.68494 M1 1 0 6 G1 Phase -1.68494 3.14433 2.756719 24156 44 873 5 0.572738 0.255402 1030|187 -0.46846 0 275 0 0 -1.76975 3.14433 69236 Gene Sets N2B|E2F2 0|7029 |TFDP2 MRE11|T 4361|715 GO OP2A|TRI GO:00071 3|9319|80 1 -1.92606 M1 1 0 Biological 19 reciprocal meiotic recombination -1.92606 3.132465 3.009368 24156 53 873 6 0.687285 0.279617 P13|RMI1| -0.62558 0 156 0 0 -2.83533 5.764605 31 010|8405 Processes MND1|E 7|146956 ME1 BRCA1|D 672|1789| GO NMT3B| GO:00616 2122|408 1 -1.92606 M1 1 0 Biological 19 histone H3-K9 modification -1.92606 3.132465 3.009368 24156 53 873 6 0.687285 0.279617 MECOM| -0.62558 0 184 0 0 -2.53893 6.917526 47 9|55183|7 Processes SMAD4|RI 9723 F1|SUV39 87|2275|1 ACTN1|F GO 0529|113 HL3|NEBL GO:00324 Cellular 1 -1.67357 M1 1 0 20 actin filament bundle -1.67357 2.515464 2.579069 24156 77 873 7 0.801833 0.301847 46|22998| |SYNPO|LI -0.45866 0 48 0 0 -5.29557 3.217454 32 Compone 27295|35 MCH1|PD nts 9845 LIM3|RFL COL5A1| 1289|149 GO CCN2|ITG GO:00329 0|3673|95 1 -1.92606 M1 1 0 Biological 19 collagen biosynthetic process -1.92606 3.132465 3.009368 24156 53 873 6 0.687285 0.279617 A2|ADAM -0.62558 0 256 1 1 -1.92606 4.256939 64 08|28984| Processes TS3|RGCC 642658 |SCX CDK1|CR ABP2|CRE 983|1382| B1|FGF2|F 1385|224 OXS1|FN 7|2307|23 1|GOLGA 35|2803|4 4|MEF2C| GO 208|4916| GO:00459 NTRK3|PR 1 -1.92342 M1 1 0 Biological 19 positive regulation of growth -1.92342 1.804572 2.603115 24156 276 873 18 2.061856 0.480948 5629|638 -0.62558 0 29 0 0 -6.42481 3.074456 27 OX1|CXC Processes 7|6422|78 L12|SFRP 52|9423|1 1|CXCR4| 0413|234 NTN1|YA 14|55031| P1|ZFPM 151835 2|USP47| CPNE9 GO GO:19037 55835|85 CENPJ|CE 1 -1.91611 M1 1 0 Biological 19 regulation of centriole elongation -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 19 0 0 -7.81934 13.83505 22 459 P295 Processes GO GO:00517 meiotic sister chromatid cohesion, BUB1|BU 1 -1.91611 M1 1 0 Biological 19 -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 699|701 -0.62558 0 25 0 0 -7.23866 13.83505 54 centromeric B1B Processes ALOX5|XI 240|331|3 AP|LAMA 909|3914| 3|LAMB3| KEGG 5600|713 MAPK11| 1 -1.66951 hsa05145 M1 1 0 24 Toxoplasmosis -1.66951 2.203814 2.483678 24156 113 873 9 1.030928 0.341867 -0.45511 0 77 0 0 -4.11211 18.44674 Pathway 2|10454|7 TNFRSF1 9444|284 A|TAB1|BI 217 RC7|LAM A1 CHRNA1| GABRA2| 1134|255 GABRA3| 5|2556|25 GABRA4| 57|2565|2 GABRG1| 890|2902| GRIA1|GR 3739|375 IN1|KCNA 9|3762|63 4|KCNJ2| 28|7223|9 KCNJ5|SC GO GO:00228 312|1036 N3A|TRP 1 -1.66736 M1 1 0 Molecular 21 substrate-specific channel activity -1.66736 1.562547 2.265617 24156 425 873 24 2.749141 0.553399 -0.45322 0 97 0 0 -3.64921 2.294594 38 9|22821|2 C4|KCNB Functions 7133|550 2|CACNG 13|81033| 2|RASA3| 83959|84 KCNH5|M 329|1175 CUB|KCN 31|12675 H6|SLC4A 5|133060| 11|HVCN 196527 1|TMC1|L RRC38|O TOP1|AN GO GO:00109 negative regulation of SMAD protein 753|5693 LDLRAD4| 1 -1.91611 M1 1 0 Biological 19 -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 84 0 0 -3.88473 11.06804 91 complex assembly 7 PMEPA1 Processes CCND2|C CNG2|CD 894|901|1 KN2B|SM 030|4089| AD4|PRK KEGG 5563|560 1 -1.66468 hsa04068 M1 1 0 24 FoxO signaling pathway -1.66468 2.09622 2.445418 24156 132 873 10 1.145475 0.360151 AA2|MAP -0.45132 0 37 0 0 -6.01116 5.929308 Pathway 0|8743|91 K11|TNFS 33|10733| F10|CCNB 85417 2|PLK4|C CNB3 GO GO:20009 regulation of forebrain neuron 3280|562 HES1|PR 1 -1.91611 M1 1 0 Biological 19 -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 92 0 0 -3.73382 12.29782 77 differentiation 9 OX1 Processes CHRNA1| 1134|289 GRIA1|GR 0|2902|37 IN1|KCNA 39|3759|3 4|KCNJ2| 762|6328| KCNJ5|SC 7223|931 N3A|TRP GO 2|10369|2 C4|KCNB GO:00052 1 -1.66412 M1 1 0 Molecular 21 cation channel activity -1.66412 1.663709 2.299636 24156 316 873 19 2.176403 0.493838 2821|271 2|CACNG -0.45128 0 97 0 0 -3.64921 2.294594 61 Functions 33|81033| 2|RASA3| 83959|84 KCNH5|K 329|1175 CNH6|SL 31|12675 C4A11|H 5|133060| VCN1|TM 196527 C1|LRRC3 8|OTOP1| GO TNFRSF1 GO:19023 positive regulation of apoptotic process 7132|713 1 -1.91611 M1 1 0 Biological 19 -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 A|TNFRSF -0.62558 0 113 0 0 -3.34087 13.83505 39 involved in morphogenesis 3 Processes 1B GO GO:20004 8772|729 FADD|CC 1 -1.91611 M1 1 0 Biological 19 regulation of T cell extravasation -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 152 0 0 -2.8845 27.6701 07 230 R2 Processes GO GO:00455 3624|642 INHBA|SF 1 -1.91611 M1 1 0 Biological 19 negative regulation of B cell differentiation -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 157 0 0 -2.83533 11.06804 78 2 RP1 Processes GO CDK1|PRK GO:00351 983|5563| 1 -1.65943 M1 1 0 Molecular 21 histone kinase activity -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 AA2|AUR -0.45097 0 128 0 0 -3.12886 18.44674 73 6790 Functions KA GO GO:00610 4222|642 MEOX1|S 1 -1.91611 M1 1 0 Biological 19 sclerotome development -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 159 0 0 -2.83085 13.83505 56 658 CX Processes GO GO:00158 5174|854 PDZK1|SL 1 -1.91611 M1 1 0 Biological 19 carnitine transport -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 209 0 0 -2.2632 11.06804 79 13 C22A16 Processes GO GO:00020 reduction of food intake in response to 80010|38 RMI1|GFR 1 -1.91611 M1 1 0 Biological 19 -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 210 0 0 -2.2632 11.06804 23 dietary excess 9400 AL Processes GO GO:19905 4603|150 MYBL1|G 1 -1.91611 M1 1 0 Biological 19 piRNA biosynthetic process -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 226 0 0 -2.13239 11.06804 11 763 PAT2 Processes GO GO:19042 positive regulation of chemokine (C-C 4155|106 MBP|POS 1 -1.91611 M1 1 0 Biological 19 -1.91611 11.06804 4.35967 24156 5 873 2 0.229095 0.161809 -0.62558 0 258 1 1 -1.91611 11.06804 09 motif) ligand 2 secretion 31 TN Processes BRCA1|BR 672|675|8 CA2|CAS GO 35|3090|6 P2|HIC1|C GO:00086 intrinsic apoptotic signaling pathway in 1 -1.9094 M1 1 0 Biological 19 -1.9094 2.417776 2.792112 24156 103 873 9 1.030928 0.341867 387|6498| XCL12|SKI -0.6198 0 113 0 0 -3.34087 13.83505 30 response to DNA damage Processes 7132|713 L|TNFRSF 3|55031 1A|TNFRS F1B|USP4 BRCA1|FA 672|2187| NCB|HIC1 3090|536 GO |PMAIP1| GO:20010 positive regulation of response to DNA 6|6498|27 1 -1.9094 M1 1 0 Biological 19 -1.9094 2.417776 2.792112 24156 103 873 9 1.030928 0.341867 SKIL|ANK -0.6198 0 262 1 1 -1.9094 4.368964 22 damage stimulus 063|5478 Processes RD1|NSM 0|55183|8 CE4A|RIF 3933 1|HDAC1 GO 143686|1 SESN3|B GO:00358 Cellular 1 -1.65943 M1 1 0 20 Seh1-associated complex -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 54743|65 MT2|CAS -0.45097 0 222 0 0 -2.17721 4.882959 59 Compone 2968 TOR1 nts TXNRD1| KEGG 7296|906 1 -1.65943 hsa00450 M1 1 0 24 Selenocompound metabolism -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 PAPSS1|T -0.45097 0 230 0 0 -2.12745 13.83505 Pathway 1|10587 XNRD2 GO ACTN1|A GO:00311 Cellular 87|88|103 1 -1.65943 M1 1 0 20 pseudopodium -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 CTN2|KL -0.45097 0 259 0 0 -1.91611 11.06804 43 Compone 24 HL41 nts GO MCM6|D GO:00171 single-stranded DNA-dependent ATP- 4175|790 1 -1.65943 M1 1 0 Molecular 21 -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 SCC1|PIF -0.45097 0 261 0 0 -1.91252 4.882959 16 dependent DNA helicase activity 75|80119 Functions 1 GO MCM6|D GO:00431 single-stranded DNA-dependent ATPase 4175|790 1 -1.65943 M1 1 0 Molecular 21 -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 SCC1|PIF -0.45097 0 261 0 0 -1.91252 4.882959 42 activity 75|80119 Functions 1 KPNA2|S Canonical 3838|408 1 -1.65943 M228 M1 1 0 11 PID SMAD2 3PATHWAY -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 MAD4|M -0.45097 0 278 0 0 -1.75049 9.223368 Pathways 9|4214 AP3K1 CDK1|CR 983|1385| EB1|FGF2| GO 2247|420 MEF2C|Y GO:19018 positive regulation of muscle tissue 1 -1.90219 M1 1 0 Biological 19 -1.90219 2.573963 2.831372 24156 86 873 8 0.91638 0.322501 8|10413|1 AP1|PPAR -0.61383 0 117 0 0 -3.28848 6.510612 63 development Processes 0891|234 GC1A|ZFP 14|93649 M2|MYO CD CHRNA1| GABRA2| 1134|255 GABRA3| 5|2556|25 GABRA4| 57|2565|2 GABRG1| 890|2902| GRIA1|GR 3739|375 IN1|KCNA GO 9|3762|63 4|KCNJ2| GO:00228 1 -1.65882 M1 1 0 Molecular 21 gated channel activity -1.65882 1.637284 2.284704 24156 338 873 20 2.290951 0.50637 28|9312|1 KCNJ5|SC -0.45092 0 97 0 0 -3.64921 2.294594 36 Functions 0369|228 N3A|KCN 21|27133| B2|CACN 81033|84 G2|RASA 329|1175 3|KCNH5| 31|12675 KCNH6|H 5|196527 VCN1|TM C1|LRRC3 8|ANO6 EPHB1|EP 2047|204 HB2|GRIN 8|2902|49 GO 1|NTRK3| GO:00480 16|7074|2 1 -1.90219 M1 1 0 Biological 19 ephrin receptor signaling pathway -1.90219 2.573963 2.831372 24156 86 873 8 0.91638 0.322501 TIAM1|SI -0.61383 0 126 0 0 -3.20893 9.223368 13 6037|642 Processes PA1L1|AR 83|28465 HGEF28|E 6 PHA10 1894|949 ECT2|KIF2 GO GO:00325 3|9585|54 3|KIF20B| 1 -1.89679 M1 1 0 Biological 19 cytokinetic process -1.89679 3.547449 3.082956 24156 39 873 5 0.572738 0.255402 -0.61098 0 102 0 0 -3.49473 18.44674 06 443|5516 ANLN|CE Processes 5 P55 BRCA1|D GO 672|1789| NMT3B| GO:00515 1 -1.89679 M1 1 0 Biological 19 histone H3-K9 methylation -1.89679 3.547449 3.082956 24156 39 873 5 0.572738 0.255402 2122|551 MECOM| -0.61098 0 184 0 0 -2.53893 6.917526 67 Processes 83|79723 RIF1|SUV 39H2 5366|702 PMAIP1|T R-HSA- Reactome 1 -1.65759 M1 1 0 6 Activation of BH3-only proteins -1.65759 3.689347 2.854013 24156 30 873 4 0.45819 0.22857 9|8655|90 FDP2|DY -0.45092 0 260 0 0 -1.91611 11.06804 114452 Gene Sets 427 NLL1|BM 1841|185 DTYMK|D R-HSA- Reactome Interconversion of nucleotide di- and 1 -1.65759 M1 1 0 6 -1.65759 3.689347 2.854013 24156 30 873 4 0.45819 0.22857 4|6241|72 UT|RRM2| -0.45092 0 266 0 0 -1.88377 7.905744 499943 Gene Sets triphosphates 96 TXNRD1 3931|512 LCAT|PCS R-HSA- Reactome 1 -1.65759 M1 1 0 6 Plasma lipoprotein remodeling -1.65759 3.689347 2.854013 24156 30 873 4 0.45819 0.22857 5|9388|51 K5|LIPG|A -0.45092 0 287 1 1 -1.65759 3.689347 8963899 Gene Sets 129 NGPTL4 VCAN|UG 1462|735 GO DH|CHST GO:00302 8|51363|5 1 -1.89679 M1 1 0 Biological 19 chondroitin sulfate metabolic process -1.89679 3.547449 3.082956 24156 39 873 5 0.572738 0.255402 15|CSGAL -0.61098 0 228 0 0 -2.12745 13.83505 04 5790|133 Processes NACT1|E 584 GFLAM 1393|367 CRHBP|IT 2|5179|70 GA1|PEN GO 54|9312|1 K|TH|KCN GO:00432 Cellular 1346|571 B2|SYNP 1 -1.65022 M1 1 0 20 perikaryon -1.65022 2.002442 2.400658 24156 152 873 11 1.260023 0.37751 -0.44405 0 41 0 0 -5.7705 2.075258 04 Compone 65|57537| O|GJC2|S nts 85397|85 ORCS2|R 442|7292 GS8|KND 30 C1|CCR2 ACTN1|C 87|1003|5 DH5|CLD 010|5175| N11|PEC KEGG 5600|638 AM1|MA 1 -1.6474 hsa04670 M1 1 0 24 Leukocyte transendothelial migration -1.6474 2.184482 2.454634 24156 114 873 9 1.030928 0.341867 -0.44185 0 132 0 0 -3.08964 3.175258 Pathway 7|7852|58 PK11|CXC 494|1005 L12|CXCR 06658 4|JAM2|O CLN GO COL4A5| GO:00380 1287|128 1 -1.89598 M1 1 0 Biological 19 collagen-activated signaling pathway -1.89598 5.929308 3.572354 24156 14 873 3 0.343643 0.198061 COL4A6|I -0.61098 0 5 0 0 -15.2617 12.29782 65 8|3673 Processes TGA2 GO BMP7|TN GO:19047 regulation of apoptotic process involved in 655|7132| 1 -1.89598 M1 1 0 Biological 19 -1.89598 5.929308 3.572354 24156 14 873 3 0.343643 0.198061 FRSF1A|T -0.61098 0 113 0 0 -3.34087 13.83505 48 development 7133 Processes NFRSF1B GO VEGFD|P GO:00509 2277|522 1 -1.89598 M1 1 0 Biological 19 induction of positive chemotaxis -1.89598 5.929308 3.572354 24156 14 873 3 0.343643 0.198061 GF|CXCL1 -0.61098 0 137 0 0 -3.04056 10.37629 30 8|6387 Processes 2 GO ACTN2|A GO:00381 88|186|81 1 -1.89598 M1 1 0 Biological 19 angiotensin-activated signaling pathway -1.89598 5.929308 3.572354 24156 14 873 3 0.343643 0.198061 GTR2|CA -0.61098 0 164 0 0 -2.711 11.06804 66 5 Processes MK2A DTYMK|E 1841|204 PHB2|ITP Canonical 8|3706|10 1 -1.64649 M9526 M1 1 0 11 ST T CELL SIGNAL TRANSDUCTION -1.64649 3.074456 2.697081 24156 45 873 5 0.572738 0.255402 KA|RASG -0.44185 0 257 0 0 -1.91611 11.06804 Pathways 125|2578 RP1|RASG 0 RP3 GO ADORA2 GO:00431 135|5795| 1 -1.89598 M1 1 0 Biological 19 negative regulation of vascular permeability -1.89598 5.929308 3.572354 24156 14 873 3 0.343643 0.198061 A|PTPRJ|R -0.61098 0 252 0 0 -1.94359 7.905744 16 10266 Processes AMP2 GO GO:00713 1393|642 CRHBP|SF 1 -1.89598 M1 1 0 Biological 19 cellular response to estrogen stimulus -1.89598 5.929308 3.572354 24156 14 873 3 0.343643 0.198061 -0.61098 0 263 1 1 -1.89598 5.929308 91 2|119392 RP1|SFR1 Processes AGTR2|C 186|1545| YP1B1|FG 2247|232 F2|FLT4|IT 4|3673|36 GA2|ITGB 90|4017|4 3|LOXL2| 208|4233| MEF2C|M 5175|558 ET|PECA GO GO:00901 7|5629|69 M1|PRKD 1 -1.89412 M1 1 0 Biological 19 epithelium migration -1.89412 1.681608 2.530153 24156 362 873 22 2.520046 0.530463 -0.60974 0 15 0 0 -9.08083 2.73285 32 15|7057|2 1|PROX1| Processes 8984|299 TBXA2R|T 41|54443| HBS1|RG 54567|57 CC|PKN3| 381|5760 ANLN|DL 8|79812|1 L4|RHOJ|J 47372 CAD|MM RN2|CCB 4751|507 NEK2|PA GO GO:00322 regulation of telomere maintenance via 3|7520|54 RN|XRCC 1 -1.88801 M1 1 0 Biological 19 -1.88801 3.074456 2.955056 24156 54 873 6 0.687285 0.279617 -0.60485 0 85 0 0 -3.87201 3.458763 10 telomerase 464|8011 5|XRN1|PI Processes 9|80169 F1|CTC1 5629|545 PROX1|D GO 67|57165| GO:20001 positive regulation of neural precursor cell LL4|GJC2| 1 -1.88801 M1 1 0 Biological 19 -1.88801 3.074456 2.955056 24156 54 873 6 0.687285 0.279617 57540|57 -0.60485 0 105 0 0 -3.44041 3.074456 79 proliferation DISP3|CIP Processes 650|2592 2A|ASPM 66 ALDH1A3 220|1381| |CRABP1| 1382|154 CRABP2| GO GO:00015 5|2239|60 CYP1B1|G 1 -1.88377 M1 1 0 Biological 19 retinoid metabolic process -1.88377 2.394528 2.759685 24156 104 873 9 1.030928 0.341867 -0.60121 0 131 0 0 -3.08989 10.37629 23 17|8854|9 PC4|RLBP Processes 249|1575 1|ALDH1 06 A2|DHRS 3|RDH10 4361|475 MRE11|N GO 1|5073|75 EK2|PAR GO:00070 1 -1.8828 M1 1 0 Biological 19 telomere maintenance via telomerase -1.8828 2.76701 2.866797 24156 70 873 7 0.801833 0.301847 20|54464| N|XRCC5| -0.60116 0 85 0 0 -3.87201 3.458763 04 Processes 80119|80 XRN1|PIF 169 1|CTC1 ECT2|HTR 2B|ASAP2 1894|335 |USP6NL| 7|8853|97 GIT2|ARH 12|9815|9 GAP11A| 824|9938| ARHGAP2 22821|23 GO 5|RASA3| GO:00050 216|2578 1 -1.62928 M1 1 0 Molecular 21 GTPase activator activity -1.62928 1.704318 2.278753 24156 276 873 17 1.947308 0.467671 TBC1D1|R -0.42996 0 130 0 0 -3.11246 1.704318 96 0|26037|5 Functions ASGRP3|S 5635|557 IPA1L1|D 89|57568| EPDC1|D 85397|20 EPDC1B|S 2151|255 IPA1L2|R 520 GS8|RAN BP3L|ELM 3280|420 HES1|ME GO 8|6491|96 F2C|STIL| GO:00031 1 -1.8828 M1 1 0 Biological 19 embryonic heart tube morphogenesis -1.8828 2.76701 2.866797 24156 70 873 7 0.801833 0.301847 45|10413| MICAL2|Y -0.60116 0 216 0 0 -2.20732 5.270496 43 Processes 51098|33 AP1|IFT52 9829 |CCDC39 H2AZ1|H 3015|835 3C10|SM 7|10051|1 GO C4|SMC2| 0592|233 GO:00448 Cellular NCAPH|N 1 -1.6256 M1 1 0 20 DNA packaging complex -1.6256 2.165486 2.425889 24156 115 873 9 1.030928 0.341867 97|54892| -0.42996 0 36 0 0 -6.06241 22.13608 15 Compone CAPG2|M 55506|64 nts ACROH2 151|6536 A2|NCAP 04 G|H3C13 SMAD4| 4089|422 MEOX1|S GO 2|6422|69 GO:00017 FRP1|TCF 1 -1.8828 M1 1 0 Biological 19 somitogenesis -1.8828 2.76701 2.866797 24156 70 873 7 0.801833 0.301847 39|8854|9 -0.60116 0 267 1 1 -1.8828 4.611684 56 15|ALDH1 Processes 096|4414 A2|TBX18 78 |NRARP ADORA2 135|1385| A|CREB1| 1849|420 DUSP7|M R-HSA- Reactome 8|4916|51 EF2C|NTR 1 -1.6245 M1 1 0 6 Signaling by NTRKs -1.6245 2.064933 2.393654 24156 134 873 10 1.145475 0.360151 -0.42996 0 255 0 0 -1.94359 11.06804 166520 Gene Sets 25|5600|6 K3|PCSK5 456|7074| |MAPK11| 23237 SH3GL2|T IAM1|AR 947|2122| CD34|ME 2247|104 COM|FGF GO 13|10736| 2|YAP1|SI GO:00720 1 -1.88191 M1 1 0 Biological 19 stem cell proliferation -1.88191 2.268041 2.718889 24156 122 873 10 1.145475 0.360151 54820|80 X2|NDE1| -0.60057 0 268 1 1 -1.88191 2.268041 89 Processes 169|1314 CTC1|TRI 05|25926 M71|ASP 6|407738 M|TAFA1 CALB2|C DH5|CMK 794|1003| LR1|DRD5 1240|181 |EDN2|ED 6|1907|19 N3|FGF2| 08|2247|2 GPR17|LP 840|2846| AR4|GRIA 2890|290 1|GRIN1| 2|3357|51 HTR2B|P GO 56|6387|6 GO:00068 DGFRA|C 1 -1.87682 M1 1 0 Biological 19 cellular calcium ion homeostasis -1.87682 1.582824 2.476121 24156 472 873 27 3.092784 0.58593 869|6915| -0.59578 0 94 0 0 -3.67332 2.548562 74 XCL12|TA Processes 7223|785 CR1|TBXA 2|9104|10 2R|TRPC4 590|1134 |CXCR4|R 6|22821|3 GN|SCGN 0001|515 |SYNPO|R 54|55013| ASA3|ER 64072|72 O1A|ACK 9230 R4|MCUB| CDH23|C CREB1|CC 1385|149 N2|PRKA GO 0|5563|64 A2|SFRP1| GO:00705 1 -1.87383 M1 1 0 Biological 19 response to fatty acid -1.87383 2.544377 2.794314 24156 87 873 8 0.91638 0.322501 22|7520|1 XRCC5|PP -0.59309 0 165 0 0 -2.70943 2.669922 42 Processes 0891|511 ARGC1A|I 41|84687 NSIG2|PP P1R9B 4175|436 MCM6|M GO 1|7520|54 RE11|XRC GO:00036 1 -1.61896 M1 1 0 Molecular 21 DNA helicase activity -1.61896 2.451781 2.502677 24156 79 873 7 0.801833 0.301847 821|7907 C5|ERCC6 -0.42996 0 261 0 0 -1.91252 4.882959 78 Functions 5|80119|2 L|DSCC1| 54394 PIF1|MC GO 947|3976| CD34|LIF| GO:00722 cell differentiation involved in metanephros 1 -1.87161 M1 1 0 Biological 19 -1.87161 4.256939 3.217428 24156 26 873 4 0.45819 0.22857 10413|10 YAP1|SIX -0.59298 0 118 0 0 -3.28677 7.905744 02 development Processes 736 2 GO 3280|397 HES1|LIF| GO:00722 1 -1.87161 M1 1 0 Biological 19 metanephric nephron morphogenesis -1.87161 4.256939 3.217428 24156 26 873 4 0.45819 0.22857 6|10736|3 SIX2|SOX -0.59298 0 118 0 0 -3.28677 7.905744 73 Processes 0812 8 ADORA2 GO 135|2287 GO:00519 positive regulation of synaptic transmission, A|NLGN1| 1 -1.87161 M1 1 0 Biological 19 -1.87161 4.256939 3.217428 24156 26 873 4 0.45819 0.22857 1|57616|7 -0.59298 0 202 0 0 -2.32557 4.882959 68 glutamatergic TSHZ3|CC Processes 29230 R2 GO 2200|811 FBN1|GP GO:19030 1 -1.87161 M1 1 0 Biological 19 regulation of bone development -1.87161 4.256939 3.217428 24156 26 873 4 0.45819 0.22857 1|9104|35 R68|RGN| -0.59298 0 218 0 0 -2.20452 7.546392 10 Processes 9845 RFLNB VCAN|UG GO 1462|735 GO:00302 DH|CHST 1 -1.87161 M1 1 0 Biological 19 chondroitin sulfate biosynthetic process -1.87161 4.256939 3.217428 24156 26 873 4 0.45819 0.22857 8|51363|5 -0.59298 0 228 0 0 -2.12745 13.83505 06 15|CSGAL Processes 5790 NACT1 GO 1490|367 CCN2|ITG GO:00329 positive regulation of collagen biosynthetic 1 -1.87161 M1 1 0 Biological 19 -1.87161 4.256939 3.217428 24156 26 873 4 0.45819 0.22857 3|28984|6 A2|RGCC| -0.59298 0 256 0 0 -1.92606 4.256939 67 process Processes 42658 SCX ADORA2 A|ADORA 135|136|1 2B|AGTR2 86|1131|1 GO |CHRM3| GO:00352 816|1907| 1 -1.86939 M1 1 0 Biological 19 regulation of tube diameter -1.86939 2.158661 2.671872 24156 141 873 11 1.260023 0.37751 DRD5|ED -0.59166 0 115 0 0 -3.30059 4.19244 96 1908|326 Processes N2|EDN3| 9|3357|36 HRH1|HT 72|6915 R2B|ITGA 1|TBXA2R ADORA2 A|ADORA 135|136|1 2B|AGTR2 86|1131|1 GO |CHRM3| GO:00508 816|1907| 1 -1.86939 M1 1 0 Biological 19 regulation of blood vessel size -1.86939 2.158661 2.671872 24156 141 873 11 1.260023 0.37751 DRD5|ED -0.59166 0 115 0 0 -3.30059 4.19244 80 1908|326 Processes N2|EDN3| 9|3357|36 HRH1|HT 72|6915 R2B|ITGA 1|TBXA2R ADORA2 A|ADORA 135|136|1 2B|AGTR2 86|1131|1 GO |CHRM3| GO:00977 816|1907| 1 -1.86939 M1 1 0 Biological 19 regulation of blood vessel diameter -1.86939 2.158661 2.671872 24156 141 873 11 1.260023 0.37751 DRD5|ED -0.59166 0 115 0 0 -3.30059 4.19244 46 1908|326 Processes N2|EDN3| 9|3357|36 HRH1|HT 72|6915 R2B|ITGA 1|TBXA2R CREB1|D 1385|184 USP7|ME 9|4208|42 R-HSA- Reactome F2C|MAP 1 -1.61535 M1 1 0 6 Toll Like Receptor 9 (TLR9) Cascade -1.61535 2.28207 2.44991 24156 97 873 8 0.91638 0.322501 14|5600|8 -0.42996 0 255 0 0 -1.94359 11.06804 168138 Gene Sets 3K1|MAP 767|1045 K11|RIPK2 4|51284 |TAB1|TLR GO GO:00055 Cellular 1287|128 COL4A5| 1 -1.61479 M1 1 0 20 collagen type IV trimer -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 5 0 0 -15.2617 12.29782 87 Compone 8 COL4A6 nts CORUM:1 FA core complex (Fanconi anemia core 2187|218 FANCB|F 1 -1.61479 M1 1 0 CORUM 33 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 44 0 0 -5.52611 9.223368 625 complex) 8 ANCF GO GO:00705 Cellular BARD1|B 1 -1.61479 M1 1 0 20 BRCA1-A complex -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 580|672 -0.42996 0 70 0 0 -4.32747 27.6701 31 Compone RCA1 nts GO GO:00616 RNA polymerase II sequence-specific DNA- 27063|93 ANKRD1| 1 -1.61479 M1 1 0 Molecular 21 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 72 0 0 -4.32747 27.6701 29 binding transcription factor binding 649 MYOCD Functions ADORA2 A|AGTR2| FAS|BRCA 135|186|3 1|BRCA2| 55|672|67 CASP2|CY 5|835|154 P1B1|E2F 5|1870|30 2|HIC1|IN 90|3624|3 HBA|LGA 958|5366| LS3|PMAI 6387|642 P1|CXCL1 2|6498|70 2|SFRP1|S 29|7057|7 GO KIL|TFDP2 GO:00971 078|7132| 1 -1.86778 M1 1 0 Biological 19 apoptotic signaling pathway -1.86778 1.504305 2.436649 24156 607 873 33 3.780069 0.645469 |THBS1|TI -0.59036 0 52 0 0 -5.08367 9.88218 90 7133|874 Processes MP3|TNF 3|8772|98 RSF1A|TN 12|9833|1 FRSF1B|T 0413|300 NFSF10|F 01|50486| ADD|DEL 53832|55 E1|MELK| 023|5503 YAP1|ER 1|90427|2 O1A|G0S 19790|38 2|IL20RA| 9400 PHIP|USP 47|BMF|R TKN2|GFR ADORA2 A|XIAP|BI 135|331|3 RC5|FAS| 32|355|14 CCN2|GRI 90|2902|5 N1|PMAI GO 366|7057| GO:20001 regulation of cysteine-type endopeptidase P1|THBS1 1 -1.86473 M1 1 0 Biological 19 -1.86473 1.852392 2.564343 24156 239 873 16 1.832761 0.453972 8743|876 -0.58821 0 116 0 0 -3.2998 2.23146 16 activity |TNFSF10| Processes 7|8772|98 RIPK2|FA 12|9966|2 DD|DELE1 3151|550 |TNFSF15| 31|79444 GRAMD4| USP47|BI ACTC1|A HR|BRCA 70|196|67 1|CDK1|C 2|983|103 DO1|CRH 6|1393|29 BP|GRIN1 GO 02|3624|4 GO:00973 |INHBA|N 1 -1.86473 M1 1 0 Biological 19 response to alcohol -1.86473 1.852392 2.564343 24156 239 873 16 1.832761 0.453972 916|5179| -0.58821 0 150 0 0 -2.88568 1.913358 05 TRK3|PEN Processes 5563|642 K|PRKAA2 2|6915|70 |SFRP1|TB 54|54464| XA2R|TH| 84687 XRN1|PPP 1R9B ACTN2|E 88|2048|5 PHB2|PD 174|9104| GO ZK1|RGN| GO:00324 positive regulation of ion transmembrane 10369|23 1 -1.85853 M1 1 0 Biological 19 -1.85853 2.371723 2.727632 24156 105 873 9 1.030928 0.341867 CACNG2| -0.58321 0 45 0 0 -5.5147 9.223368 14 transporter activity 237|5499 Processes ARC|TESC 7|126755| |LRRC38| 729230 CCR2 R-HSA- Reactome Activation of NIMA Kinases NEK9, NEK6, CDK1|CC 1 -1.61479 M1 1 0 6 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 983|9133 -0.42996 0 110 0 0 -3.35124 18.44674 2980767 Gene Sets NEK7 NB2 AGTR2|D 186|1600| AB1|GAR 2618|527 T|SERPIN GO GO:00215 0|5629|60 E2|PROX1 1 -1.85853 M1 1 0 Biological 19 cerebellum development -1.85853 2.371723 2.727632 24156 105 873 9 1.030928 0.341867 -0.58321 0 92 0 0 -3.73382 12.29782 49 95|9928|1 |RORA|KIF Processes 0891|854 14|PPARG 42 C1A|KND C1 COMT|EP 1312|204 HB1|GRIN 7|2902|36 GO 1|ITGA2| GO:00192 73|4886|5 1 -1.85853 M1 1 0 Biological 19 sensory perception of pain -1.85853 2.371723 2.727632 24156 105 873 9 1.030928 0.341867 NPY1R|PE -0.58321 0 151 0 0 -2.8845 27.6701 33 179|6387| Processes NK|CXCL 7852|729 12|CXCR4 230 |CCR2 ADORA2 A|AGTR2| 135|186|3 FAS|BRCA 55|672|83 1|CASP2|I 5|3624|39 NHBA|LG 58|5366|6 ALS3|PM 387|6422| AIP1|CXC 6498|702 L12|SFRP GO 9|7057|70 GO:20012 1|SKIL|TF 1 -1.85824 M1 1 0 Biological 19 regulation of apoptotic signaling pathway -1.85824 1.627653 2.475868 24156 408 873 24 2.749141 0.553399 78|8743|8 -0.58321 0 52 0 0 -5.08367 9.88218 33 DP2|THBS Processes 772|1041 1|TIMP3|T 3|50486|5 NFSF10|F 3832|550 ADD|YAP 23|55031| 1|G0S2|IL 90427|21 20RA|PHI 9790|389 P|USP47| 400 BMF|RTK N2|GFRA ADORA2 A|BMP7|B RCA1|LDL 135|655|6 RAD4|CD 72|753|10 KN2B|DN 30|1789|1 MT3B|DU 849|2048| SP7|EPHB 2122|395 2|MECO 8|3976|40 M|LGALS 89|4916|5 3|LIF|SMA 167|5563| D4|NTRK 5783|579 3|ENPP1| 5|6422|64 PRKAA2|P GO GO:00314 negative regulation of protein modification 56|7078|9 TPN13|PT 1 -1.85545 M1 1 0 Biological 19 -1.85545 1.490941 2.419747 24156 631 873 34 3.894616 0.654786 -0.58072 0 167 0 0 -2.69166 1.668549 00 process 104|1049 PRJ|SFRP Processes 1|10891|1 1|SH3GL2 1072|228 |TIMP3|R 43|54997| GN|CRTA 56937|57 P|PPARG 718|8468 C1A|DUS 7|84930|9 P14|PPM 3649|116 1E|TESC|P 496|3926 MEPA1|P 17|10050 PP4R4|PP 6658 P1R9B|M ASTL|MY OCD|NIB AN1|ELFN ASPA|HES GO 443|3280| GO:00487 regulation of oligodendrocyte 1|TNFRSF 1 -1.85158 M1 1 0 Biological 19 -1.85158 3.458763 3.013597 24156 40 873 5 0.572738 0.255402 7133|785 -0.57888 0 56 0 0 -4.84716 6.385408 13 differentiation 1B|CXCR4 Processes 2|85414 |SLC45A3 9104|270 RGN|ANK GO GO:20002 negative regulation of DNA biosynthetic 63|54464| RD1|XRN 1 -1.85158 M1 1 0 Biological 19 -1.85158 3.458763 3.013597 24156 40 873 5 0.572738 0.255402 -0.57888 0 85 0 0 -3.87201 3.458763 79 process 80119|80 1|PIF1|CT Processes 169 C1 AGTR2|D GO 186|1816| GO:00019 regulation of systemic arterial blood RD5|EDN 1 -1.85158 M1 1 0 Biological 19 -1.85158 3.458763 3.013597 24156 40 873 5 0.572738 0.255402 1907|190 -0.57888 0 187 0 0 -2.48174 18.44674 90 pressure by hormone 2|EDN3|P Processes 8|5125 CSK5 88|1908|3 ACTN2|E GO GO:19013 positive regulation of potassium ion 759|1267 DN3|KCN 1 -1.85158 M1 1 0 Biological 19 -1.85158 3.458763 3.013597 24156 40 873 5 0.572738 0.255402 -0.57888 0 221 0 0 -2.17721 3.532354 81 transmembrane transport 55|19652 J2|LRRC3 Processes 7 8|ANO6 1490|401 CCN2|LO GO 7|5744|10 XL2|PTHL GO:00610 1 -1.85106 M1 1 0 Biological 19 regulation of cartilage development -1.85106 2.728038 2.823582 24156 71 873 7 0.801833 0.301847 736|9146 H|SIX2|PK -0.57888 0 53 0 0 -4.98746 13.83505 35 Processes 1|359845| DCC|RFL 642658 NB|SCX GO GO:00058 Cellular 1062|819 CENPE|KI 1 -1.61479 M1 1 0 20 kinetochore microtubule -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 155 0 0 -2.83885 13.83505 28 Compone 30 F18A nts CHRNA1| 1134|375 GO KCNJ2|TN GO:00508 9|7135|71 1 -1.85094 M1 1 0 Biological 19 multicellular organismal movement -1.85094 3.018557 2.90199 24156 55 873 6 0.687285 0.279617 NI1|TNNI -0.57888 0 61 0 0 -4.53228 18.44674 79 36|7139|7 Processes 2|TNNT2| 140 TNNT3 GO ADORA2 GO:00016 G protein-coupled adenosine receptor 1 -1.61479 M1 1 0 Molecular 21 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 135|136 A|ADORA -0.42996 0 171 0 0 -2.66202 13.83505 09 activity Functions 2B GO GO:00986 3672|367 ITGA1|IT 1 -1.61479 M1 1 0 Molecular 21 cell-matrix adhesion mediator activity -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 186 0 0 -2.51714 11.06804 34 3 GA2 Functions GO GO:00324 5395|254 PMS2|MC 1 -1.61479 M1 1 0 Molecular 21 MutSalpha complex binding -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 192 0 0 -2.41795 18.44674 07 394 M9 Functions GO GO:00050 vascular endothelial growth factor- 2324|515 FLT4|PDG 1 -1.61479 M1 1 0 Molecular 21 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 196 0 0 -2.41795 18.44674 21 activated receptor activity 6 FRA Functions GO GO:00380 2324|515 FLT4|PDG 1 -1.61479 M1 1 0 Molecular 21 vascular endothelial growth factor binding -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 196 0 0 -2.41795 18.44674 85 6 FRA Functions CHRNA1| 1134|375 GO KCNJ2|TN GO:00508 9|7135|71 1 -1.85094 M1 1 0 Biological 19 musculoskeletal movement -1.85094 3.018557 2.90199 24156 55 873 6 0.687285 0.279617 NI1|TNNI -0.57888 0 61 0 0 -4.53228 18.44674 81 36|7139|7 Processes 2|TNNT2| 140 TNNT3 SMAD4|P 4089|562 GO ROX1|TN GO:00032 ventricular cardiac muscle tissue 9|7135|71 1 -1.85094 M1 1 0 Biological 19 -1.85094 3.018557 2.90199 24156 55 873 6 0.687285 0.279617 NI1|TNNT -0.57888 0 75 0 0 -4.23321 3.816566 29 development 39|23414| Processes 2|ZFPM2| 54567 DLL4 ACTN2|E PHB2|GP 88|2048|2 C4|GOLG 239|2803| A4|GRIN1 2902|395 |LGALS3|P 8|5593|71 RKG2|TNF 32|9312|9 RSF1A|KC GO 648|1026 GO:19907 NB2|GCC 1 -1.84895 M1 1 0 Biological 19 protein localization to cell periphery -1.84895 1.713319 2.499119 24156 323 873 20 2.290951 0.50637 6|10369|2 -0.57719 0 270 1 1 -1.84895 2.110432 78 2|RAMP2| Processes 3433|544 CACNG2| 43|54997| RHOQ|A 81619|84 NLN|TES 455|8468 C|TSPAN 7|91461|1 14|EFCAB 31578 7|PPP1R9 B|PKDCC| GO GO:00711 Cellular 4089|409 SMAD4|S 1 -1.61479 M1 1 0 20 SMAD protein complex -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 197 0 0 -2.41795 18.44674 41 Compone 0 MAD5 nts ADORA2 A|ADORA 135|136|1 2B|AGTR2 86|1131|1 GO |CHRM3| GO:00351 816|1907| 1 -1.84827 M1 1 0 Biological 19 regulation of tube size -1.84827 2.143459 2.646206 24156 142 873 11 1.260023 0.37751 DRD5|ED -0.57711 0 115 0 0 -3.30059 4.19244 50 1908|326 Processes N2|EDN3| 9|3357|36 HRH1|HT 72|6915 R2B|ITGA 1|TBXA2R AGTR2|C 186|947|3 D34|HTR2 357|4155| B|MBP|M GO 5600|876 APK11|RI GO:00507 1 -1.84827 M1 1 0 Biological 19 positive regulation of cytokine secretion -1.84827 2.143459 2.646206 24156 142 873 11 1.260023 0.37751 7|10125|1 PK2|RASG -0.57711 0 133 0 0 -3.08066 2.143459 15 Processes 0631|289 RP1|POST 84|79679| N|RGCC| 114899 VTCN1|C 1QTNF3 GO GO:00047 7296|105 TXNRD1| 1 -1.61479 M1 1 0 Molecular 21 thioredoxin-disulfide reductase activity -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 230 0 0 -2.12745 13.83505 91 87 TXNRD2 Functions CDK1|NE 983|4751| K2|PCNT| 5116|599 RFX4|DY 2|8655|96 NLL1|CEP 62|9712|9 135|USP6 814|1073 NL|SFI1|P 3|23216|2 LK4|TBC1 5886|510 D1|POC1 GO 98|51715| GO:00447 A|IFT52|R 1 -1.84652 M1 1 0 Biological 19 cilium organization -1.84652 1.623674 2.463235 24156 409 873 24 2.749141 0.553399 54820|55 -0.57626 0 12 0 0 -10.0997 6.06468 82 AB23|ND Processes 112|5512 E1|WDR6 5|55835|7 0|CEP192| 9441|801 CENPJ|H 84|11717 AUS3|CEP 8|121441| 290|SSX2I 161582|3 P|NEDD1| 39829|34 DNAAF4| 7240 CCDC39| CRABP2|F 1382|233 N1|GOLG GO 5|2803|49 GO:00507 A4|NTRK3 1 -1.84595 M1 1 0 Biological 19 positive regulation of axonogenesis -1.84595 2.515464 2.75777 24156 88 873 8 0.91638 0.322501 16|6387|6 -0.57626 0 29 0 0 -6.42481 3.074456 72 |CXCL12|S Processes 498|7074| KIL|TIAM 9423 1|NTN1 ADORA2 A|ADORA 135|136|1 2B|AGTR2 86|1131|1 |CHRM3| 395|1816| CRHR2|D 2913|326 RD5|GRM GO G protein-coupled receptor signaling GO:00071 9|3357|41 3|HRH1|H 1 -1.84061 M1 1 0 Biological 19 pathway, coupled to cyclic nucleotide -1.84061 1.802267 2.523347 24156 261 873 17 1.947308 0.467671 -0.57122 0 115 0 0 -3.30059 4.19244 87 61|4883|4 TR2B|MC Processes second messenger 886|5744| 5R|NPR3| 6915|101 NPY1R|PT 49|10266| HLH|TBX 64123 A2R|ADG RG2|RAM P2|ADGR BMP7|DA 655|1600| B1|EPHB1 2047|204 |EPHB2|S 8|4089|49 MAD4|NR 02|6387|7 TN|CXCL1 852|9423| 2|CXCR4| GO GO:00974 9723|237 NTN1|SE 1 -1.83605 M1 1 0 Biological 19 neuron projection guidance -1.83605 1.766177 2.506006 24156 282 873 18 2.061856 0.480948 -0.56695 0 29 0 0 -6.42481 3.074456 85 68|54437| MA3E|FLR Processes 55816|91 T2|SEMA 624|9165 5B|DOK5| 3|133584| NEXN|BO 284217|2 C|EGFLA 84656 M|LAMA1 |EPHA10 ADORA2 A|AGTR2| SLC25A4| 135|186|2 BARD1|C 91|580|94 D34|CDK 7|983|189 1|ECT2|ST 4|2040|23 OM|FN1| 35|3357|4 HTR2B|M 155|5116| BP|PCNT| 5174|560 PDZK1|M 0|6422|70 APK11|SF 74|7133|8 RP1|TIAM 111|8767| 1|TNFRSF 9324|958 GO 1B|GPR68 GO:00512 5|9648|10 1 -1.83462 M1 1 0 Biological 19 regulation of protein transport -1.83462 1.450295 2.383757 24156 725 873 38 4.352806 0.690579 |RIPK2|H -0.56581 0 133 0 0 -3.08066 2.143459 23 125|1063 Processes MGN3|KI 1|23086|2 F20B|GCC 3379|270 2|RASGRP 63|28984| 1|POSTN| 29969|51 EXPH5|IC 512|5171 E1|ANKR 5|79679|8 D1|RGCC| 0184|844 MDFIC|G 55|91461| TSE1|RAB 94121|11 23|VTCN1 4899|131 |CEP290|E 450 FCAB7|PK DCC|SYTL 4|C1QTN GO GO:00380 Cellular G protein-coupled receptor dimeric 10266|16 RAMP2|G 1 -1.61479 M1 1 0 20 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 252 0 0 -1.94359 7.905744 37 Compone complex 5829 PR156 nts BRCA1|C 672|835|9 ASP2|CD 83|6790|7 GO K1|AURK GO:00711 029|2898 1 -1.83366 M1 1 0 Biological 19 regulation of cell cycle arrest -1.83366 2.349348 2.695943 24156 106 873 9 1.030928 0.341867 A|TFDP2| -0.56573 0 30 0 0 -6.32789 4.035223 56 4|51512|7 Processes RGCC|GT 9366|144 SE1|HMG 455 N5|E2F7 GO GO:00302 ACTN2|RI 1 -1.61479 M1 1 0 Molecular 21 LIM domain binding -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 88|8767 -0.42996 0 259 0 0 -1.91611 11.06804 74 PK2 Functions FAS|BRCA 355|672|3 1|LGALS3| 958|7057| GO THBS1|TN GO:20012 negative regulation of extrinsic apoptotic 8743|877 1 -1.83366 M1 1 0 Biological 19 -1.83366 2.349348 2.695943 24156 106 873 9 1.030928 0.341867 FSF10|FA -0.56573 0 52 0 0 -5.08367 9.88218 37 signaling pathway 2|10413|5 Processes DD|YAP1| 5023|389 PHIP|GFR 400 AL ADORA2 A|BMP7|L DLRAD4| 135|655|7 CDKN2B| 53|1030|1 DUSP7|EP 849|2048| HB2|MEC 2122|362 OM|INHB 4|3976|40 A|LIF|SM 89|4916|5 AD4|NTR 167|5783| K3|ENPP1 GO 5795|642 GO:00423 |PTPN13| 1 -1.82277 M1 1 0 Biological 19 negative regulation of phosphorylation -1.82277 1.566232 2.418596 24156 477 873 27 3.092784 0.58593 2|6456|70 -0.55543 0 167 0 0 -2.69166 1.668549 26 PTPRJ|SF Processes 78|8655|9 RP1|SH3G 104|1089 L2|TIMP3| 1|11072|2 DYNLL1|R 2843|549 GN|PPAR 97|56937| GC1A|DU 93649|11 SP14|PP 6496|100 M1E|TESC 506658 |PMEPA1| MYOCD| NIBAN1| ADORA2 135|2913| A|GRM3| GO 4208|527 GO:00519 regulation of synaptic transmission, MEF2C|SE 1 -1.81996 M1 1 0 Biological 19 -1.81996 2.690149 2.781109 24156 72 873 7 0.801833 0.301847 0|22871|5 -0.55321 0 202 0 0 -2.32557 4.882959 66 glutamatergic RPINE2|N Processes 7616|729 LGN1|TS 230 HZ3|CCR CD34|FGF 947|2247| 2|PDGFR GO 5156|527 A|SERPIN GO:19030 negative regulation of response to 1 -1.81856 M1 1 0 Biological 19 -1.81856 2.4872 2.721728 24156 89 873 8 0.91638 0.322501 0|7056|70 E2|THBD| -0.55239 0 108 0 0 -3.3802 5.825285 35 wounding Processes 57|56963| THBS1|RG 170692 MA|ADA MTS18 CORUM:1 DNA double-strand break end-joining 4361|752 MRE11|X 1 -1.61479 M1 1 0 CORUM 33 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 276 0 0 -1.75049 9.223368 189 complex 0 RCC5 CORUM:1 4361|752 MRE11|X 1 -1.61479 M1 1 0 CORUM 33 Rap1 complex -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 276 0 0 -1.75049 9.223368 193 0 RCC5 CORUM:2 4361|752 MRE11|X 1 -1.61479 M1 1 0 CORUM 33 TERF2-RAP1 complex -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 276 0 0 -1.75049 9.223368 766 0 RCC5 4089|422 SMAD4| 2|6422|69 MEOX1|S GO GO:00610 39|8854|9 FRP1|TCF 1 -1.81856 M1 1 0 Biological 19 somite development -1.81856 2.4872 2.721728 24156 89 873 8 0.91638 0.322501 -0.55239 0 267 0 0 -1.8828 4.611684 53 096|4414 15|ALDH1 Processes 78|64265 A2|TBX18 8 |NRARP|S R-HSA- Reactome 5558|801 PRIM2|CT 1 -1.61479 M1 1 0 6 Telomere C-strand synthesis initiation -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 290 1 1 -1.61479 7.905744 174430 Gene Sets 69 C1 CORUM:1 CTCF-nucleophosmin-PARP-HIS-KPNA- 3015|715 H2AZ1|T 1 -1.61479 M1 1 0 CORUM 33 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 291 0 0 -1.61479 7.905744 728 LMNA-TOP complex 3 OP2A GO H2AZ1|M GO:00017 Cellular 3015|555 1 -1.61479 M1 1 0 20 Barr body -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 ACROH2 -0.42996 0 291 1 1 -1.61479 7.905744 40 Compone 06 A2 nts 186|655|3 AGTR2|B GO GO:00901 976|1041 MP7|LIF|Y 1 -1.8148 M1 1 0 Biological 19 regulation of kidney development -1.8148 2.964654 2.850117 24156 56 873 6 0.687285 0.279617 -0.55124 0 118 0 0 -3.28677 7.905744 83 3|10736|3 AP1|SIX2| Processes 0812 SOX8 655|3976| BMP7|LIF| GO GO:20002 7272|931 TTK|TRIP1 1 -1.8148 M1 1 0 Biological 19 negative regulation of reproductive process -1.8148 2.964654 2.850117 24156 56 873 6 0.687285 0.279617 -0.55124 0 217 0 0 -2.20452 9.223368 42 9|23213|2 3|SULF1|Z Processes 3414 FPM2 ACTN1|A GTR2|LDL 87|186|75 RAD4|CY 3|1545|22 P1B1|FGF 47|4208|5 2|MEF2C| 795|6387| PTPRJ|CX 6422|691 CL12|SFR 5|7057|70 P1|TBXA2 GO GO:00512 negative regulation of cellular component 75|9104|9 R|THBS1| 1 -1.81455 M1 1 0 Biological 19 -1.81455 1.631827 2.43581 24156 390 873 23 2.634593 0.542066 -0.55124 0 15 0 0 -9.08083 2.73285 71 movement 723|1089 TIE1|RGN| Processes 1|22998|2 SEMA3E| 3213|289 PPARGC1 84|54567| A|LIMCH1 79148|79 |SULF1|R 812|9364 GCC|DLL4 9|131450 |MMP28| MMRN2| MYOCD| ENTPD2| 954|2618| GART|EN 5167|516 PP1|ENPP 9|5471|55 3|PPAT|P KEGG 58|5634|6 1 -1.61008 hsa00230 M1 1 0 24 Purine metabolism -1.61008 1.908283 2.328329 24156 174 873 12 1.37457 0.394068 RIM2|PRP -0.42875 0 135 0 0 -3.06206 13.83505 Pathway 241|9061| S2|RRM2| 10606|50 PAPSS1|P 808|8461 AICS|AK3| 8 NT5C1A GO 6915|705 TBXA2R|T GO:00301 1 -1.81429 M1 1 0 Biological 19 positive regulation of blood coagulation -1.81429 4.099275 3.120064 24156 27 873 4 0.45819 0.22857 6|7057|19 HBD|THB -0.55124 0 108 0 0 -3.3802 5.825285 94 Processes 6527 S1|ANO6 GO 6915|705 TBXA2R|T GO:19000 1 -1.81429 M1 1 0 Biological 19 positive regulation of hemostasis -1.81429 4.099275 3.120064 24156 27 873 4 0.45819 0.22857 6|7057|19 HBD|THB -0.55124 0 108 0 0 -3.3802 5.825285 48 Processes 6527 S1|ANO6 GO 3280|397 HES1|LIF| GO:00722 1 -1.81429 M1 1 0 Biological 19 metanephric epithelium development -1.81429 4.099275 3.120064 24156 27 873 4 0.45819 0.22857 6|10413|3 YAP1|SO -0.55124 0 118 0 0 -3.28677 7.905744 07 Processes 0812 X8 GO 1490|367 CCN2|ITG GO:00107 positive regulation of collagen metabolic 1 -1.81429 M1 1 0 Biological 19 -1.81429 4.099275 3.120064 24156 27 873 4 0.45819 0.22857 3|28984|6 A2|RGCC| -0.55124 0 256 0 0 -1.92606 4.256939 14 process Processes 42658 SCX GO 3672|367 ITGA1|IT GO:00083 Cellular 1 -1.60984 M1 1 0 20 integrin complex -1.60984 3.570336 2.772862 24156 31 873 4 0.45819 0.22857 3|3690|36 GA2|ITGB -0.42875 0 186 0 0 -2.51714 11.06804 05 Compone 91 3|ITGB4 nts ADORA2 GO 135|4208| GO:00485 A|MEF2C| 1 -1.81429 M1 1 0 Biological 19 positive regulation of behavior -1.81429 4.099275 3.120064 24156 27 873 4 0.45819 0.22857 5179|228 -0.55124 0 271 1 1 -1.81429 7.905744 20 PENK|NL Processes 71 GN1 ACTN2|S 88|6456|9 H3GL2|MI 645|9928| CAL2|KIF1 11004|22 4|KIF2C|T 974|2658 PX2|CKAP GO 6|29766|5 GO:00436 2|TMOD3 1 -1.81326 M1 1 0 Biological 19 cellular protein complex disassembly -1.81326 1.869602 2.520463 24156 222 873 15 1.718213 0.439813 0853|571 -0.55124 0 40 0 0 -5.92255 5.29853 24 |VILL|TRI Processes 59|81930| M54|KIF1 84687|12 8A|PPP1R 6731|344 9B|CCSAP 148|3472 |NCKAP5| 40 KIF24 CREB1|D 1385|184 R-HSA- Reactome MAPK targets/ Nuclear events mediated by USP7|ME 1 -1.60984 M1 1 0 6 -1.60984 3.570336 2.772862 24156 31 873 4 0.45819 0.22857 9|4208|56 -0.42875 0 255 0 0 -1.94359 11.06804 450282 Gene Sets MAP kinases F2C|MAP 00 K11 GO BRCA2|M GO:19029 675|4175| 1 -1.81071 M1 1 0 Biological 19 mitotic DNA replication -1.81071 5.534021 3.401282 24156 15 873 3 0.343643 0.198061 CM6|CDC -0.55124 0 20 0 0 -7.69554 7.546392 69 8318 Processes 45 GO H2AZ1|EE 3015|872 GO:00008 Cellular D|PLK4|M 1 -1.60984 M1 1 0 20 sex chromosome -1.60984 3.570336 2.772862 24156 31 873 4 0.45819 0.22857 6|10733|5 -0.42875 0 291 0 0 -1.61479 7.905744 03 Compone ACROH2 5506 nts A2 GO GO:00703 3673|562 ITGA2|PR 1 -1.81071 M1 1 0 Biological 19 hepatocyte differentiation -1.81071 5.534021 3.401282 24156 15 873 3 0.343643 0.198061 -0.55124 0 92 0 0 -3.73382 12.29782 65 9|144455 OX1|E2F7 Processes MAP3K1| 4214|713 TNFRSF1 Canonical 1 -1.60921 M128 M1 1 0 11 PID TNF PATHWAY -1.60921 3.00762 2.639083 24156 46 873 5 0.572738 0.255402 2|7133|87 A|TNFRSF -0.42875 0 113 0 0 -3.34087 13.83505 Pathways 72|10454 1B|FADD| TAB1 GO GO:00721 3976|420 LIF|MEF2 1 -1.81071 M1 1 0 Biological 19 nephron tubule epithelial cell differentiation -1.81071 5.534021 3.401282 24156 15 873 3 0.343643 0.198061 -0.55124 0 118 0 0 -3.28677 7.905744 60 8|10413 C|YAP1 Processes GO ALDH1A3 GO:00161 220|8854| 1 -1.81071 M1 1 0 Biological 19 terpenoid biosynthetic process -1.81071 5.534021 3.401282 24156 15 873 3 0.343643 0.198061 |ALDH1A -0.55124 0 131 0 0 -3.08989 10.37629 14 157506 Processes 2|RDH10 GO ALDH1A3 GO:00435 220|5629| 1 -1.81071 M1 1 0 Biological 19 nose development -1.81071 5.534021 3.401282 24156 15 873 3 0.343643 0.198061 |PROX1|R -0.55124 0 131 0 0 -3.08989 10.37629 84 157506 Processes DH10 GO GO:20010 positive regulation of endothelial cell 2247|423 FGF2|MET 1 -1.81071 M1 1 0 Biological 19 -1.81071 5.534021 3.401282 24156 15 873 3 0.343643 0.198061 -0.55124 0 232 0 0 -2.12027 5.534021 28 chemotaxis 3|5587 |PRKD1 Processes 2239|369 GPC4|ITG GO GO:00150 0|7852|10 B3|CXCR4 1 -1.60921 M1 1 0 Molecular 21 coreceptor activity -1.60921 3.00762 2.639083 24156 46 873 5 0.572738 0.255402 -0.42875 0 295 1 1 -1.60921 3.00762 26 266|5696 |RAMP2|R Functions 3 GMA GO positive regulation of DNA damage HIC1|PM GO:00435 3090|536 1 -1.81071 M1 1 0 Biological 19 response, signal transduction by p53 class -1.81071 5.534021 3.401282 24156 15 873 3 0.343643 0.198061 AIP1|ANK -0.55124 0 260 0 0 -1.91611 11.06804 17 6|27063 Processes mediator RD1 CHRNA1| GABRA2| 1134|255 GABRA3| 5|2556|25 GO GABRA4| GO:00152 57|2565|2 1 -1.60479 M1 1 0 Molecular 21 ligand-gated ion channel activity -1.60479 2.049637 2.368109 24156 135 873 10 1.145475 0.360151 GABRG1| -0.42506 0 112 0 0 -3.34087 10.06186 76 890|2902| Functions GRIA1|GR 3759|376 IN1|KCNJ 2|22821 2|KCNJ5| RASA3 CHRNA1| GABRA2| 1134|255 GABRA3| 5|2556|25 GO GABRA4| GO:00228 57|2565|2 1 -1.60479 M1 1 0 Molecular 21 ligand-gated channel activity -1.60479 2.049637 2.368109 24156 135 873 10 1.145475 0.360151 GABRG1| -0.42506 0 112 0 0 -3.34087 10.06186 34 890|2902| Functions GRIA1|GR 3759|376 IN1|KCNJ 2|22821 2|KCNJ5| RASA3 GO GO:00092 1841|185 DTYMK|D 1 -1.81071 M1 1 0 Biological 19 deoxyribonucleotide biosynthetic process -1.81071 5.534021 3.401282 24156 15 873 3 0.343643 0.198061 -0.55124 0 266 0 0 -1.88377 7.905744 63 4|6241 UT|RRM2 Processes BRCA2|M 675|4175| CM6|PMS 5395|831 GO 2|CDC45| GO:00036 8|10051|1 1 -1.60412 M1 1 0 Molecular 21 single-stranded DNA binding -1.60412 2.146818 2.397439 24156 116 873 9 1.030928 0.341867 SMC4|SM -0.42486 0 20 0 0 -7.69554 7.546392 97 0592|553 Functions C2|MCM1 88|80169| 0|CTC1|M 254394 CM9 CHRNA1| GABRA2| 1134|255 GABRA3| 5|2556|25 GABRA4| 57|2565|2 GABRG1| 890|2902| GRIA1|GR 3739|375 GO IN1|KCNA 9|3762|63 GO:19024 Cellular 4|KCNJ2| 1 -1.60242 M1 1 0 20 transmembrane transporter complex -1.60242 1.637794 2.227495 24156 321 873 19 2.176403 0.493838 28|7223|9 -0.42341 0 97 0 0 -3.64921 2.294594 95 Compone KCNJ5|SC 312|1036 nts N3A|TRP 9|22871|5 C4|KCNB 5013|126 2|CACNG 755|1965 2|NLGN1| 27|37556 MCUB|LR 7 RC38|AN O6|VWC2 GO ADORA2 GO:00601 135|2173| 1 -1.81071 M1 1 0 Biological 19 prepulse inhibition -1.81071 5.534021 3.401282 24156 15 873 3 0.343643 0.198061 A|FABP7| -0.55124 0 272 1 1 -1.81071 5.534021 34 2902 Processes GRIN1 BRCA1|C 672|983|2 DK1|FHL1 273|4361| GO |MRE11|O GO:19027 negative regulation of cell cycle G2/M 4998|679 1 -1.80916 M1 1 0 Biological 19 -1.80916 2.327392 2.66461 24156 107 873 9 1.030928 0.341867 RC1|AUR -0.55124 0 208 0 0 -2.2632 4.323454 50 phase transition 0|51514|5 Processes KA|DTL|U 5031|639 SP47|CLS 67 PN ADORA2 A|ALDH1 135|220|1 A3|CHRN GO 134|2173| GO:00509 A1|FABP7 1 -1.80916 M1 1 0 Biological 19 neuromuscular process -1.80916 2.327392 2.66461 24156 107 873 9 1.030928 0.341867 2307|290 -0.55124 0 272 0 0 -1.81071 5.534021 05 |FOXS1|G Processes 2|5179|69 RIN1|PEN 39|64072 K|TCF15| CDH23 DRD5|GRI GO 1816|290 GO:00076 N1|SERPI 1 -1.80786 M1 1 0 Biological 19 mating -1.80786 3.374403 2.946415 24156 41 873 5 0.572738 0.255402 2|5270|70 -0.55124 0 123 0 0 -3.23644 5.764605 18 NE2|TH|P Processes 54|84687 PP1R9B CDK1|AU R-HSA- Reactome TP53 Regulates Transcription of Genes 983|6790| 1 -1.59183 M1 1 0 6 -1.59183 4.611684 2.968155 24156 18 873 3 0.343643 0.198061 RKA|TFDP -0.41662 0 128 0 0 -3.12886 18.44674 6804114 Gene Sets Involved in G2 Cell Cycle Arrest 7029 2 CRABP2| 1382|885 GO ALDH1A2 GO:00351 4|116039| 1 -1.80786 M1 1 0 Biological 19 forelimb morphogenesis -1.80786 3.374403 2.946415 24156 41 873 5 0.572738 0.255402 |OSR2|RD -0.55124 0 176 0 0 -2.63058 4.19244 36 157506|3 Processes H10|RSP 40419 O2 XIAP|GAS GO 331|2619| GO:00109 1|SERPIN 1 -1.80786 M1 1 0 Biological 19 negative regulation of protein processing -1.80786 3.374403 2.946415 24156 41 873 5 0.572738 0.255402 5270|705 -0.55124 0 273 1 1 -1.80786 9.223368 55 E2|THBS1 Processes 7|79444 |BIRC7 XIAP|GAS GO 331|2619| GO:19033 1|SERPIN 1 -1.80786 M1 1 0 Biological 19 negative regulation of protein maturation -1.80786 3.374403 2.946415 24156 41 873 5 0.572738 0.255402 5270|705 -0.55124 0 273 0 0 -1.80786 9.223368 18 E2|THBS1 Processes 7|79444 |BIRC7 ACTN2|C 88|1003|1 DH5|CCN 490|4089| 2|SMAD4| 4208|423 MEF2C|M 3|5629|63 ET|PROX1 87|6422|7 |CXCL12|S 456|1078 FRP1|WIP GO 8|11346|2 F1|IQGAP GO:19029 regulation of supramolecular fiber 1 -1.79489 M1 1 0 Biological 19 -1.79489 1.645249 2.421915 24156 370 873 22 2.520046 0.530463 2843|229 2|SYNPO| -0.53884 0 14 0 0 -9.68163 3.166231 03 organization Processes 74|22998| PPM1E|T 26586|28 PX2|LIMC 984|2976 H1|CKAP 6|50853|5 2|RGCC|T 7159|849 MOD3|VI 52|10050 LL|TRIM5 6658 4|CGNL1| OCLN GO CNN3|ST GO:00986 cadherin binding involved in cell-cell 1266|290 1 -1.59183 M1 1 0 Molecular 21 -1.59183 4.611684 2.968155 24156 18 873 3 0.343643 0.198061 XBP6|TM -0.41662 0 212 0 0 -2.24088 6.917526 41 adhesion 91|29766 Functions OD3 BMP7|LD 655|753|4 LRAD4|L GO 017|4089| GO:00107 regulation of epithelial to mesenchymal OXL2|SM 1 -1.79163 M1 1 0 Biological 19 -1.79163 2.459565 2.686172 24156 90 873 8 0.91638 0.322501 6422|707 -0.53615 0 84 0 0 -3.88473 11.06804 17 transition AD4|SFRP Processes 4|28984|2 1|TIAM1| 05717 RGCC|US R-HSA- Reactome 2619|844 GAS1|EFC 1 -1.59183 M1 1 0 6 Activation of SMO -1.59183 4.611684 2.968155 24156 18 873 3 0.343643 0.198061 -0.41662 0 225 0 0 -2.13258 6.917526 5635838 Gene Sets 55|91653 AB7|BOC 186|2247| AGTR2|F GO 3280|408 GF2|HES1 GO:00720 1 -1.78949 M1 1 0 Biological 19 nephron tubule morphogenesis -1.78949 2.653298 2.739355 24156 73 873 7 0.801833 0.301847 9|5228|10 |SMAD4|P -0.53458 0 10 0 0 -10.1376 3.952872 78 Processes 736|3081 GF|SIX2|S 2 OX8 GO EPHB1|NL GO:00324 Cellular 2047|228 1 -1.59183 M1 1 0 20 filopodium tip -1.59183 4.611684 2.968155 24156 18 873 3 0.343643 0.198061 GN1|MY -0.41662 0 264 0 0 -1.89562 4.611684 33 Compone 71|53904 O3A nts BRCA1|C 672|1312| OMT|CRH GO 1393|184 GO:00436 BP|DTYM 1 -1.78949 M1 1 0 Biological 19 response to estrogen -1.78949 2.653298 2.739355 24156 73 873 7 0.801833 0.301847 1|6422|11 -0.53458 0 263 0 0 -1.89598 5.929308 27 K|SFRP1|S Processes 9392|163 FR1|CITE 732 D4 ADORA2 A|BMP7|L 135|655|7 DLRAD4| 53|1030|1 CDKN2B| 849|2048| DUSP7|EP 2122|397 HB2|MEC 6|4089|49 OM|LIF|S 16|5167|5 MAD4|NT 783|5795| RK3|ENPP GO GO:00019 negative regulation of protein 6422|645 1|PTPN13 1 -1.78826 M1 1 0 Biological 19 -1.78826 1.586588 2.393374 24156 436 873 25 2.863688 0.564477 -0.53364 0 167 0 0 -2.69166 1.668549 33 phosphorylation 6|7078|91 |PTPRJ|SF Processes 04|10891| RP1|SH3G 11072|22 L2|TIMP3| 843|5499 RGN|PPA 7|56937|9 RGC1A|D 3649|116 USP14|PP 496|1005 M1E|TESC 06658 |PMEPA1| MYOCD| NIBAN1| ADORA2 A|ADORA 135|136|1 2B|AGTR2 86|291|81 |SLC25A4| 5|947|138 CAMK2A| 5|1393|19 CD34|CRE 08|2335|3 B1|CRHB 357|3624| P|EDN3|F 3976|408 N1|HTR2 9|4155|42 B|INHBA| 08|5600|6 LIF|SMAD 387|6422| 4|MBP|M 7074|713 EF2C|MA GO 2|7133|81 PK11|CXC GO:19035 1 -1.78757 M1 1 0 Biological 19 regulation of secretion by cell -1.78757 1.424458 2.328755 24156 777 873 40 4.581901 0.707671 11|8767|9 L12|SFRP -0.53323 0 133 0 0 -3.08066 2.143459 30 Processes 324|1012 1|TIAM1| 5|10631|1 TNFRSF1 1141|228 A|TNFRSF 71|23086| 1B|GPR68 23178|27 |RIPK2|H 063|2898 MGN3|RA 4|29091|5 SGRP1|P 5784|796 OSTN|IL1 79|94121| RAPL1|NL 114899|1 GN1|EXP 31450|72 H5|PASK| 9230 ANKRD1| RGCC|ST XBP6|MC BRCA1|BR 672|675|1 CA2|DNM 789|1894| T3B|ECT2| GO 3861|642 GO:00102 KRT14|SF 1 -1.7864 M1 1 0 Biological 19 response to ionizing radiation -1.7864 2.099111 2.570465 24156 145 873 11 1.260023 0.37751 2|7056|75 -0.53235 0 274 1 1 -1.7864 3.458763 12 RP1|THB Processes 20|10206| D|XRCC5| 10276|10 TRIM13|N 413 ET1|YAP1 ACTN2|C 88|1393|2 RHBP|ST 040|2048| OM|EPHB 2273|289 2|FHL1|G 0|2902|42 RIA1|GRI GO 08|5174|9 N1|MEF2 GO:00324 regulation of ion transmembrane 1 -1.78192 M1 1 0 Biological 19 -1.78192 1.775063 2.456598 24156 265 873 17 1.947308 0.467671 104|1036 C|PDZK1| -0.52872 0 45 0 0 -5.5147 9.223368 12 transporter activity Processes 9|10891|2 RGN|CAC 2871|232 NG2|PPA 37|54997| RGC1A|N 126755|7 LGN1|AR 29230 C|TESC|LR RC38|CCR BRCA1|C 672|1030| DKN2B|C Canonical 1385|369 1 -1.58534 M254 M1 1 0 11 PID MYC REPRESS PATHWAY -1.58534 2.635248 2.516516 24156 63 873 6 0.687285 0.279617 REB1|ITG -0.41132 0 136 0 0 -3.0513 3.816566 Pathways 1|4089|64 B4|SMAD 22 4|SFRP1 COL4A5| 1287|128 COL5A1| R-HSA- Reactome 9|1299|13 1 -1.58534 M1 1 0 6 NCAM signaling for neurite out-growth -1.58534 2.635248 2.516516 24156 63 873 6 0.687285 0.279617 COL9A3| -0.41132 0 144 0 0 -2.96243 3.816566 375165 Gene Sets 85|4902|1 CREB1|N 31873 RTN|COL CHRNA1| GABRA2| 1134|255 GABRA3| 5|2556|25 GABRA4| 57|2565|2 GABRG1| 890|2902| GRIA1|GR 3739|375 IN1|KCNA 9|3762|63 4|KCNJ2| 28|7223|9 KCNJ5|SC GO 312|1036 N3A|TRP GO:00152 1 -1.57823 M1 1 0 Molecular 21 channel activity -1.57823 1.517001 2.158197 24156 456 873 25 2.863688 0.564477 9|22821|2 C4|KCNB -0.40444 0 97 0 0 -3.64921 2.294594 67 Functions 7133|550 2|CACNG 13|57165| 2|RASA3| 81033|83 KCNH5|M 959|8432 CUB|GJC2 9|117531| |KCNH6|S 126755|1 LC4A11|H 33060|19 VCN1|TM 6527 C1|LRRC3 8|OTOP1| ANO6 PRDM1|C 639|1312| OMT|CRH 1393|367 BP|ITGA2| 3|3976|43 LIF|MMP7 GO 16|5125|5 |PCSK5|P GO:00447 1 -1.78129 M1 1 0 Biological 19 multi-multicellular organism process -1.78129 1.852909 2.483294 24156 224 873 15 1.718213 0.439813 228|5270| GF|SERPI -0.52844 0 250 0 0 -1.95348 1.996812 06 Processes 5471|574 NE2|PPAT 4|7056|10 |PTHLH|T 266|1099 HBD|RAM 1|64750 P2|SLC38 A3|SMUR AHR|CRE GO 196|1385| GO:00012 B1|SMAD 1 -1.57303 M1 1 0 Molecular 21 transcription cofactor binding -1.57303 2.943628 2.582639 24156 47 873 5 0.572738 0.255402 4089|477 -0.40114 0 178 0 0 -2.59562 18.44674 21 4|NFATC1 Functions 2|6095 |RORA ACTN2|C 88|1393|2 RHBP|ST 040|2048| OM|EPHB 2890|290 2|GRIA1| GO 2|4208|10 GRIN1|M GO:20012 1 -1.78108 M1 1 0 Biological 19 regulation of cation channel activity -1.78108 1.954953 2.51785 24156 184 873 13 1.489118 0.40992 369|1089 EF2C|CAC -0.52844 0 45 0 0 -5.5147 9.223368 57 Processes 1|22871|2 NG2|PPA 3237|126 RGC1A|N 755|7292 LGN1|AR 30 C|LRRC38 |CCR2 EDN3|AU 1908|679 GO RKA|DLG GO:00458 positive regulation of mitotic nuclear 0|9787|28 1 -1.77957 M1 1 0 Biological 19 -1.77957 2.912642 2.799387 24156 57 873 6 0.687285 0.279617 AP5|RGC -0.5275 0 51 0 0 -5.22312 2.912642 40 division 984|5120 Processes C|NUSAP 3|55023 1|PHIP 57165|57 GJC2|GJD R-HSA- Reactome 369|7986 2|TUBAL3 1 -1.57303 M1 1 0 6 Gap junction trafficking -1.57303 2.943628 2.582639 24156 47 873 5 0.572738 0.255402 -0.40114 0 241 0 0 -2.04229 3.84307 190828 Gene Sets 1|81027|2 |TUBB1|G 19770 JD4 1003|189 CDH5|EC GO 4|5175|10 T2|PECA GO:00708 1 -1.77957 M1 1 0 Biological 19 bicellular tight junction assembly -1.77957 2.912642 2.799387 24156 57 873 6 0.687285 0.279617 266|8461 M1|RAMP -0.5275 0 132 0 0 -3.08964 3.175258 30 Processes 2|100506 2|PARD6B 658 |OCLN ALOX5|C D34|CMK 240|947|1 LR1|EDN2 240|1907| |EDN3|VE 1908|227 GFD|FN1| 7|2335|29 GYPC|HR 95|3269|3 H1|ITGA1 672|3673| |ITGA2|IT 3690|395 GB3|LGAL GO 8|4312|51 S3|MMP1 GO:00509 1 -1.77345 M1 1 0 Biological 19 leukocyte migration -1.77345 1.537228 2.360104 24156 504 873 28 3.207331 0.596329 75|5228|6 |PECAM1| -0.52167 0 42 0 0 -5.75682 3.654542 00 Processes 387|7056| PGF|CXCL 7057|785 12|THBD| 2|8772|95 THBS1|CX 47|58494| CR4|FAD 79148|83 D|CXCL14 483|1314 |JAM2|M 50|19652 MP28|PL 7|729230 VAP|CD2 00R1|AN O6|CCR2 4017|516 LOXL2|EN GO GO:00050 7|8492|10 PP1|PRSS 1 -1.57303 M1 1 0 Molecular 21 scavenger receptor activity -1.57303 2.943628 2.582639 24156 47 873 5 0.572738 0.255402 -0.40114 0 297 1 1 -1.57303 2.943628 44 216|5155 12|PRG4| Functions 4 ACKR4 BMP7|CR 655|1382| ABP2|FBN 2201|408 2|SMAD4| GO 9|8854|51 GO:00303 ALDH1A2 1 -1.76975 M1 1 0 Biological 19 embryonic limb morphogenesis -1.76975 2.178748 2.57897 24156 127 873 10 1.145475 0.360151 098|1160 -0.51882 0 176 0 0 -2.63058 4.19244 26 |IFT52|OS Processes 39|15750 R2|RDH1 6|340419| 0|RSPO2| 341640 FREM2 COL4A5| 1287|128 COL4A6| 8|2277|23 VEGFD|F KEGG AGE-RAGE signaling pathway in diabetic 1 -1.56863 hsa04933 M1 1 0 24 -1.56863 2.235968 2.386136 24156 99 873 8 0.91638 0.322501 35|4089|4 N1|SMAD -0.39767 0 59 0 0 -4.67046 7.747629 Pathway complications 772|5600| 4|NFATC1 7056 |MAPK11| THBD BMP7|CR 655|1382| ABP2|FBN 2201|408 2|SMAD4| GO 9|8854|51 GO:00351 ALDH1A2 1 -1.76975 M1 1 0 Biological 19 embryonic appendage morphogenesis -1.76975 2.178748 2.57897 24156 127 873 10 1.145475 0.360151 098|1160 -0.51882 0 176 0 0 -2.63058 4.19244 13 |IFT52|OS Processes 39|15750 R2|RDH1 6|340419| 0|RSPO2| 341640 FREM2 ACTN2|C 88|1131|2 GO HRM3|GR 890|2902| GO:00988 Cellular IA1|GRIN 1 -1.56863 M1 1 0 20 postsynaptic density membrane -1.56863 2.235968 2.386136 24156 99 873 8 0.91638 0.322501 7074|103 -0.39767 0 288 0 0 -1.6474 3.570336 39 Compone 1|TIAM1| 69|23237| nts CACNG2| 57537 ARC|SOR CHRNA1| GABRA2| 1134|255 GABRA3| 5|2556|25 GABRA4| 57|2565|2 GABRG1| 890|2902| GRIA1|GR 3739|375 IN1|KCNA 9|3762|63 4|KCNJ2| 28|7223|9 KCNJ5|SC GO 312|1036 N3A|TRP GO:00228 1 -1.5683 M1 1 0 Molecular 21 passive transmembrane transporter activity -1.5683 1.513682 2.146735 24156 457 873 25 2.863688 0.564477 9|22821|2 C4|KCNB -0.39758 0 97 0 0 -3.64921 2.294594 03 Functions 7133|550 2|CACNG 13|57165| 2|RASA3| 81033|83 KCNH5|M 959|8432 CUB|GJC2 9|117531| |KCNH6|S 126755|1 LC4A11|H 33060|19 VCN1|TM 6527 C1|LRRC3 8|OTOP1| ANO6 ACTC1|A GO 70|87|227 CTN1|FHL GO:00426 Cellular 5|10529|1 1 -1.56641 M1 1 0 20 actomyosin -1.56641 2.391243 2.428587 24156 81 873 7 0.801833 0.301847 3|NEBL|SY -0.39616 0 48 0 0 -5.29557 3.217454 41 Compone 1346|229 NPO|LIM nts 98|27295 CH1|PDLI CCN2|EP 1490|204 HB1|EPH 7|2048|22 B2|FGF2|F 47|2324|2 LT4|FN1| 335|3357| HTR2B|LIF 3976|408 |SMAD4| GO GO:00703 9|4916|51 NTRK3|P 1 -1.76726 M1 1 0 Biological 19 regulation of ERK1 and ERK2 cascade -1.76726 1.706922 2.417753 24156 308 873 19 2.176403 0.493838 -0.5178 0 18 0 0 -7.89792 2.69514 72 56|7074|7 DGFRA|TI Processes 078|8767| AM1|TIM 10125|56 P3|RIPK2| 034|1521 RASGRP1| 10|28501 PDGFC|N 6|388121 EK10|ALK AL2|TNFA FAS|COM 355|1312| T|PMAIP1 5366|556 |PRKAA2| 3|5587|64 GO PRKD1|SF GO:00092 22|10991| 1 -1.76626 M1 1 0 Biological 19 cellular response to starvation -1.76626 2.084734 2.545627 24156 146 873 11 1.260023 0.37751 RP1|SLC3 -0.5178 0 50 0 0 -5.25088 2.470545 67 81788|14 Processes 8A3|NUA 3686|154 K2|SESN3 743|4407 |BMT2|M 38 AP1LC3C ESRRB|HR 2103|326 H1|ENPP 9|5167|53 1|PMAIP1 66|6095|9 GO |RORA|RG GO:00106 regulation of cellular carbohydrate 104|1089 1 -1.76626 M1 1 0 Biological 19 -1.76626 2.084734 2.545627 24156 146 873 11 1.260023 0.37751 N|PPARG -0.5178 0 251 0 0 -1.95287 3.29406 75 metabolic process 1|23178|5 Processes C1A|PASK 7486|854 |NLN|SLC 14|11489 45A3|C1 9 QTNF3 ESRRB|P 2103|536 GO MAIP1|R GO:00109 positive regulation of glucose metabolic 6|9104|10 1 -1.76556 M1 1 0 Biological 19 -1.76556 3.29406 2.881283 24156 42 873 5 0.572738 0.255402 GN|PPAR -0.5178 0 251 0 0 -1.95287 3.29406 07 process 891|8541 Processes GC1A|SLC 4 45A3 BMP7|CY 655|1591| P24A1|D GO 1789|367 NMT3B|IT GO:00332 1 -1.76516 M1 1 0 Biological 19 response to vitamin -1.76516 2.432537 2.651091 24156 91 873 8 0.91638 0.322501 3|5179|64 GA2|PEN -0.5178 0 87 0 0 -3.8385 5.234884 73 Processes 22|8854|1 K|SFRP1|A 0631 LDH1A2| POSTN GO 6915|705 TBXA2R|T GO:00508 1 -1.75965 M1 1 0 Biological 19 positive regulation of coagulation -1.75965 3.952872 3.027291 24156 28 873 4 0.45819 0.22857 6|7057|19 HBD|THB -0.5178 0 108 0 0 -3.3802 5.825285 20 Processes 6527 S1|ANO6 GO 639|3976| PRDM1|LI GO:00607 cell differentiation involved in embryonic 1 -1.75965 M1 1 0 Biological 19 -1.75965 3.952872 3.027291 24156 28 873 4 0.45819 0.22857 10733|14 F|PLK4|E2 -0.5178 0 149 0 0 -2.89663 7.905744 06 placenta development Processes 4455 F7 MAD2L1B GO 9587|289 GO:00104 P|RGCC|A 1 -1.75965 M1 1 0 Biological 19 exit from mitosis -1.75965 3.952872 3.027291 24156 28 873 4 0.45819 0.22857 84|54443| -0.5178 0 183 0 0 -2.55801 18.44674 58 NLN|PPP Processes 84687 1R9B GO 794|5716 CALB2|GJ GO:00059 Cellular 1 -1.56408 M1 1 0 20 gap junction -1.56408 3.458763 2.694996 24156 32 873 4 0.45819 0.22857 5|57369|2 C2|GJD2| -0.39594 0 241 0 0 -2.04229 3.84307 21 Compone 19770 GJD4 nts ADORA2 GO 135|2173| GO:00019 A|FABP7| 1 -1.75965 M1 1 0 Biological 19 startle response -1.75965 3.952872 3.027291 24156 28 873 4 0.45819 0.22857 2902|517 -0.5178 0 272 0 0 -1.81071 5.534021 64 GRIN1|PE Processes 9 NK 4089|420 SMAD4| GO 8|5629|71 MEF2C|P GO:00032 1 -1.75964 M1 1 0 Biological 19 cardiac ventricle morphogenesis -1.75964 2.617442 2.698296 24156 74 873 7 0.801833 0.301847 35|7139|2 ROX1|TN -0.5178 0 75 0 0 -4.23321 3.816566 08 Processes 3414|545 NI1|TNNT 67 2|ZFPM2| CD34|FGF 947|2247| 2|PDGFR GO 5156|527 GO:00610 A|SERPIN 1 -1.75964 M1 1 0 Biological 19 negative regulation of wound healing -1.75964 2.617442 2.698296 24156 74 873 7 0.801833 0.301847 0|7056|70 -0.5178 0 108 0 0 -3.3802 5.825285 45 E2|THBD| Processes 57|17069 THBS1|A 2 DAMTS18 ADORA2 A|AGTR2| 135|186|1 AHR|CDO 96|1036|1 1|CRHBP| 393|1545| CYP1B1|D 1789|181 NMT3B|D GO 6|2902|51 GO:00094 RD5|GRIN 1 -1.75233 M1 1 0 Biological 19 response to xenobiotic stimulus -1.75233 1.729381 2.411205 24156 288 873 18 2.061856 0.480948 79|5742|6 -0.5178 0 123 0 0 -3.23644 5.764605 10 1|PENK|P Processes 095|7054| TGS1|RO 7074|785 RA|TH|TI 2|8772|10 AM1|CXC 891|8468 R4|FADD| 7 PPARGC1 A|PPP1R9 ESRRB|HR H1|ITPKA| 2103|326 ENPP1|P 9|3706|51 MAIP1|R 67|5366|6 ORA|RGN 095|9104| |HS2ST1| 9653|108 PPARGC1 GO GO:00442 91|23178| A|PASK|P 1 -1.75233 M1 1 0 Biological 19 cellular carbohydrate metabolic process -1.75233 1.729381 2.411205 24156 288 873 18 2.061856 0.480948 -0.5178 0 251 0 0 -1.95287 3.29406 62 51294|51 CDH12|IS Processes 477|5579 YNA1|CS 0|57486|8 GALNACT 5414|930 1|NLN|SL 10|11489 C45A3|B3 9|116255 GNT7|C1 QTNF3|M OGAT1 STOM|IT 2040|369 GB3|LGAL 0|3958|51 S3|PECA 75|5795|7 M1|PTPRJ 133|8655| |TNFRSF1 10184|10 B|DYNLL1 GO 788|2291 |LHFPL2|I GO:00306 Cellular 1 -1.55795 M1 1 0 20 secretory granule membrane -1.55795 1.643769 2.183588 24156 303 873 18 2.061856 0.480948 8|26002|5 QGAP2|C -0.39097 0 161 0 0 -2.78242 3.040671 67 Compone 4918|798 D93|MOX nts 95|81619| D1|CMT 84329|94 M6|ATP8 121|1965 B4|TSPAN 27|40125 14|HVCN 8 1|SYTL4|A NO6|RAB GO GO:00615 55835|85 CENPJ|CE 1 -1.75049 M1 1 0 Biological 19 centriole elongation -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 19 0 0 -7.81934 13.83505 11 459 P295 Processes CREB1|D 1385|184 USP7|ME R-HSA- Reactome 9|4208|56 1 -1.55557 M1 1 0 6 MAP kinase activation -1.55557 2.594072 2.472593 24156 64 873 6 0.687285 0.279617 F2C|MAP -0.38906 0 255 0 0 -1.94359 11.06804 450294 Gene Sets 00|8767|1 K11|RIPK2 0454 |TAB1 GO GO:00480 2200|423 FBN1|MF 1 -1.75049 M1 1 0 Biological 19 post-embryonic eye morphogenesis -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 24 0 0 -7.35548 20.75258 50 7 AP2 Processes GO GO:19047 positive regulation of NMDA glutamate 2048|729 EPHB2|C 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 45 0 0 -5.5147 9.223368 83 receptor activity 230 CR2 Processes GRIN1|KC 2902|373 NA4|KCN 9|3759|37 J2|KCNJ5| 62|6328|9 SCN3A|K GO 312|1036 CNB2|CA GO:00052 1 -1.54963 M1 1 0 Molecular 21 voltage-gated ion channel activity -1.54963 1.816724 2.234466 24156 198 873 13 1.489118 0.40992 9|27133|8 CNG2|KC -0.38451 0 97 0 0 -3.64921 2.294594 44 Functions 1033|843 NH5|KCN 29|11753 H6|HVCN 1|126755| 1|TMC1|L 196527 RRC38|A NO6 GO GO:00611 5744|359 PTHLH|RF 1 -1.75049 M1 1 0 Biological 19 regulation of chondrocyte development -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 53 0 0 -4.98746 13.83505 81 845 LNB Processes GO GO:20010 negative regulation of skeletal muscle cell 2047|936 EPHB1|M 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 72 0 0 -4.32747 27.6701 15 differentiation 49 YOCD Processes CDK6|CD 1021|103 KN2B|E2F 0|1870|30 2|H2AZ1| 15|4001|4 LMNB1|M R-HSA- Reactome 361|5600| RE11|MA 1 -1.54963 M1 1 0 6 Cellular Senescence -1.54963 1.816724 2.234466 24156 198 873 13 1.489118 0.40992 -0.38451 0 275 0 0 -1.76975 3.14433 2559583 Gene Sets 5931|702 PK11|RBB 9|8357|87 P7|TFDP2 26|9134|6 |H3C10|E 53604 ED|CCNE 2|H3C13 ECT2|TIA M1|ARHG 1894|707 AP11A|A 4|9824|99 RHGAP25 38|10276| R-HSA- Reactome |NET1|RH 1 -1.54715 M1 1 0 6 Rho GTPase cycle -1.54715 2.00508 2.292783 24156 138 873 10 1.145475 0.360151 23433|26 -0.38226 0 95 0 0 -3.66655 2.902458 194840 Gene Sets OQ|ARH 084|5065 GEF26|AR 0|55789|5 HGEF3|D 7381 EPDC1B|R HOJ GO GO:00457 negative regulation of glycogen 5167|231 ENPP1|PA 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 73 0 0 -4.32747 27.6701 19 biosynthetic process 78 SK Processes GO GO:00516 55171|25 TBCCD1| 1 -1.75049 M1 1 0 Biological 19 maintenance of centrosome location -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 80 0 0 -4.01173 9.223368 61 9266 ASPM Processes GO GO:00903 6790|259 AURKA|A 1 -1.75049 M1 1 0 Biological 19 spindle assembly involved in meiosis -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 80 0 0 -4.01173 9.223368 06 266 SPM Processes GO GO:00109 regulation of SMAD protein complex 753|5693 LDLRAD4| 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 84 0 0 -3.88473 11.06804 90 assembly 7 PMEPA1 Processes GO GO:00216 2047|204 EPHB1|EP 1 -1.75049 M1 1 0 Biological 19 optic nerve morphogenesis -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 126 0 0 -3.20893 9.223368 31 8 HB2 Processes GO GO:00607 2277|522 VEGFD|P 1 -1.75049 M1 1 0 Biological 19 positive regulation of mast cell chemotaxis -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 137 0 0 -3.04056 10.37629 54 8 GF Processes GO GO:00975 FAS|FAD 1 -1.75049 M1 1 0 Biological 19 necroptotic signaling pathway -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 355|8772 -0.5178 0 141 0 0 -2.97821 18.44674 27 D Processes GO GO:00606 655|2321 BMP7|SU 1 -1.75049 M1 1 0 Biological 19 regulation of prostatic bud formation -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 153 0 0 -2.8845 27.6701 85 3 LF1 Processes FAS|CDH 5|CDH7|C 355|1003| DH9|CDH 1005|100 10|CDH1 7|1008|10 1|CHRNA 09|1134|2 1|GRIA1| 890|2902| GRIN1|IT 3672|367 GA1|ITGA 3|3690|36 2|ITGB3|I 91|3739|3 TGB4|KC 759|3762| NA4|KCN 6328|644 GO J2|KCNJ5| 5|8325|87 GO:00987 Cellular SCN3A|S 1 -1.53917 M1 1 0 20 plasma membrane protein complex -1.53917 1.401525 2.073635 24156 691 873 35 4.009164 0.663949 72|9180|9 -0.37635 0 97 0 0 -3.64921 2.294594 97 Compone GCG|FZD 312|1026 nts 8|FADD|O 6|10369|2 SMR|KCN 2871|542 B2|RAMP 21|57165| 2|CACNG 57369|64 2|NLGN1| 072|8445 SNTG2|GJ 5|126755| C2|GJD2| 165829|2 CDH23|EF 19770|22 CAB7|LRR 2256|375 C38|GPR1 567 56|GJD4| CDHR3|V GO GO:00720 mesenchymal stem cell maintenance 655|1073 BMP7|SIX 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 153 0 0 -2.8845 27.6701 38 involved in nephron morphogenesis 6 2 Processes GO GO:00606 regulation of branching involved in BMP7|SFR 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 655|6422 -0.5178 0 157 0 0 -2.83533 11.06804 87 prostate gland morphogenesis P1 Processes GO GO:00106 positive regulation of alkaline phosphatase 3673|420 ITGA2|ME 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 186 0 0 -2.51714 11.06804 94 activity 8 F2C Processes GRIN1|KC 2902|373 NA4|KCN 9|3759|37 J2|KCNJ5| 62|6328|9 SCN3A|K GO 312|1036 CNB2|CA GO:00228 1 -1.53427 M1 1 0 Molecular 21 voltage-gated channel activity -1.53427 1.807595 2.215108 24156 199 873 13 1.489118 0.40992 9|27133|8 CNG2|KC -0.3726 0 97 0 0 -3.64921 2.294594 32 Functions 1033|843 NH5|KCN 29|11753 H6|HVCN 1|126755| 1|TMC1|L 196527 RRC38|A NO6 GO GO:00031 regulation of systemic arterial blood 1907|190 EDN2|ED 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 187 0 0 -2.48174 18.44674 00 pressure by endothelin 8 N3 Processes FAS|STO M|EPHB1| 355|2040| GPM6B|IT 2047|282 GA1|PDZ 4|3672|51 K1|PECA 74|5175|5 M1|PODX GO 420|7132| L|TNFRSF GO:00451 Cellular 7133|722 1 -1.53107 M1 1 0 20 membrane raft -1.53107 1.607743 2.142556 24156 327 873 19 2.176403 0.493838 1A|TNFRS -0.37075 0 299 1 1 -1.53107 1.607743 21 Compone 3|8772|23 F1B|TRPC nts 213|2323 4|FADD|S 7|23433|5 ULF1|ARC 5824|647 |RHOQ|P 50|81930| AG1|SMU 83483 RF2|KIF18 A|PLVAP GO GO:00613 1545|284 CYP1B1|L 1 -1.75049 M1 1 0 Biological 19 retinal blood vessel morphogenesis -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 189 0 0 -2.46134 9.223368 04 217 AMA1 Processes GO GO:00156 1317|261 SLC31A1| 1 -1.75049 M1 1 0 Biological 19 copper ion import -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 190 0 0 -2.46134 9.223368 77 729 STEAP2 Processes R-HSA- Reactome Transcription of E2F targets under negative 7029|715 TFDP2|TO 1 -1.52874 M1 1 0 6 -1.52874 4.368964 2.844609 24156 19 873 3 0.343643 0.198061 -0.37075 0 109 0 0 -3.37978 5.929308 1362277 Gene Sets control by DREAM complex 3|286826 P2A|LIN9 CDK1|LM R-HSA- Reactome Initiation of Nuclear Envelope (NE) 983|4001| 1 -1.52874 M1 1 0 6 -1.52874 4.368964 2.844609 24156 19 873 3 0.343643 0.198061 NB1|CCN -0.37075 0 110 0 0 -3.35124 18.44674 2995383 Gene Sets Reformation 9133 B2 GO GO:00468 regulation of follicle-stimulating hormone 3624|408 INHBA|S 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 197 0 0 -2.41795 18.44674 80 secretion 9 MAD4 Processes GO AURKA|T GO:00430 Cellular 6790|931 1 -1.52874 M1 1 0 20 germ cell nucleus -1.52874 4.368964 2.844609 24156 19 873 3 0.343643 0.198061 RIP13|TCF -0.37075 0 128 0 0 -3.12886 18.44674 73 Compone 9|10732 L5 nts R-HSA- Reactome Caspase activation via Death Receptors in 355|8743| FAS|TNFS 1 -1.52874 M1 1 0 6 -1.52874 4.368964 2.844609 24156 19 873 3 0.343643 0.198061 -0.37075 0 141 0 0 -2.97821 18.44674 140534 Gene Sets the presence of ligand 8772 F10|FADD GO GO:00468 positive regulation of follicle-stimulating 3624|408 INHBA|S 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 197 0 0 -2.41795 18.44674 81 hormone secretion 9 MAD4 Processes GO BMP7|CD GO:00706 transmembrane receptor protein 655|1003| 1 -1.52874 M1 1 0 Molecular 21 -1.52874 4.368964 2.844609 24156 19 873 3 0.343643 0.198061 H5|INHB -0.37075 0 157 0 0 -2.83533 11.06804 96 serine/threonine kinase binding 3624 Functions A GO GO:19056 regulation of maintenance of permeability 6456|100 SH3GL2| 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 201 0 0 -2.33108 9.223368 03 of blood-brain barrier 506658 OCLN Processes GO GO:00158 5174|854 PDZK1|SL 1 -1.75049 M1 1 0 Biological 19 amino-acid betaine transport -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 209 0 0 -2.2632 11.06804 38 13 C22A16 Processes GO MCM6|D GO:00040 4175|790 1 -1.52874 M1 1 0 Molecular 21 ATP-dependent DNA helicase activity -1.52874 4.368964 2.844609 24156 19 873 3 0.343643 0.198061 SCC1|PIF -0.37075 0 261 0 0 -1.91252 4.882959 03 75|80119 Functions 1 GO MCM6|D GO:00080 4175|790 1 -1.52874 M1 1 0 Molecular 21 ATP-dependent helicase activity -1.52874 4.368964 2.844609 24156 19 873 3 0.343643 0.198061 SCC1|PIF -0.37075 0 261 0 0 -1.91252 4.882959 26 75|80119 Functions 1 GO MCM6|D GO:00700 4175|790 1 -1.52874 M1 1 0 Molecular 21 purine NTP-dependent helicase activity -1.52874 4.368964 2.844609 24156 19 873 3 0.343643 0.198061 SCC1|PIF -0.37075 0 261 0 0 -1.91252 4.882959 35 75|80119 Functions 1 GO GO:00163 7272|233 TTK|NCA 1 -1.75049 M1 1 0 Biological 19 female meiosis chromosome segregation -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 217 0 0 -2.20452 9.223368 21 97 PH Processes GO GO:20005 regulation of ATP-dependent microtubule 8655|551 DYNLL1| 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 246 0 0 -1.98904 9.223368 80 motor activity, plus-end-directed 12 WDR60 Processes GO positive regulation of ATP-dependent GO:20005 8655|551 DYNLL1| 1 -1.75049 M1 1 0 Biological 19 microtubule motor activity, plus-end- -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 246 0 0 -1.98904 9.223368 82 12 WDR60 Processes directed GO GO:00107 negative regulation of plasminogen 5270|705 SERPINE2 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 273 0 0 -1.80786 9.223368 57 activation 7 |THBS1 Processes GO GO:00102 3070|291 HELLS|UH 1 -1.75049 M1 1 0 Biological 19 maintenance of DNA methylation -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 277 0 0 -1.75049 9.223368 16 28 RF1 Processes CCND2|C 894|1021| DK6|E2F2| Canonical 1870|420 1 -1.52649 M279 M1 1 0 11 PID RB 1PATHWAY -1.52649 2.554163 2.429501 24156 65 873 6 0.687285 0.279617 MEF2C|M -0.36963 0 275 0 0 -1.76975 3.14433 Pathways 8|4233|56 ET|MAPK 00 11 GO GO:20003 regulation of DNA topoisomerase (ATP- 23397|29 NCAPH|U 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 277 1 1 -1.75049 9.223368 71 hydrolyzing) activity 128 HRF1 Processes GO GO:20003 positive regulation of DNA topoisomerase 23397|29 NCAPH|U 1 -1.75049 M1 1 0 Biological 19 -1.75049 9.223368 3.900838 24156 6 873 2 0.229095 0.161809 -0.5178 0 277 0 0 -1.75049 9.223368 73 (ATP-hydrolyzing) activity 128 HRF1 Processes ACTN2|A GTR2|BM P7|BRCA1 88|186|65 |CAMK2A 5|672|815 |CHRM3| |1131|138 CREB1|CR 5|1393|13 HBP|CRH 95|1583|1 R2|CYP11 789|2103| A1|DNMT 2200|301 3B|ESRRB| 5|3624|36 FBN1|H2 73|4208|5 AZ1|INHB 167|5228| A|ITGA2| GO 5471|556 MEF2C|E GO:00328 1 -1.74839 M1 1 0 Biological 19 cellular response to hormone stimulus -1.74839 1.437913 2.296692 24156 712 873 37 4.238259 0.68184 3|6095|62 NPP1|PG -0.51597 0 150 0 0 -2.88568 1.913358 70 Processes 58|6422|1 F|PPAT|P 0266|104 RKAA2|R 13|10891| ORA|RXR 23433|55 G|SFRP1| 023|5693 RAMP2|Y 7|81930|8 AP1|PPAR 4687|853 GC1A|RH 15|85397| OQ|PHIP| 133060|1 PMEPA1| 43686|16 KIF18A|P 1582 PP1R9B|P AQR8|RG S8|OTOP 1|SESN3| CDK1|FGF 983|2247| GO 2|MEF2C| GO:00600 regulation of cardiac muscle cell 4208|560 1 -1.7452 M1 1 0 Biological 19 -1.7452 2.862424 2.749751 24156 58 873 6 0.687285 0.279617 MAPK11| -0.51332 0 117 0 0 -3.28848 6.510612 43 proliferation 0|10413|2 Processes YAP1|ZFP 3414 M2 2335|705 FN1|THBS Canonical 1 -1.52018 M277 M1 1 0 11 PID INTEGRIN A4B1 PATHWAY -1.52018 3.353952 2.620174 24156 33 873 4 0.45819 0.22857 7|7058|58 1|THBS2|J -0.36544 0 163 0 0 -2.77297 7.905744 Pathways 494 AM2 GO 2535|642 FZD2|SFR GO:00171 1 -1.52018 M1 1 0 Molecular 21 Wnt-protein binding -1.52018 3.353952 2.620174 24156 33 873 4 0.45819 0.22857 2|6425|83 P1|SFRP5| -0.36544 0 169 0 0 -2.68015 3.353952 47 Functions 25 FZD8 TNNT2|D 7139|865 GO YNLL1|RG GO:00327 5|9104|23 1 -1.7452 M1 1 0 Biological 19 positive regulation of ATPase activity -1.7452 2.862424 2.749751 24156 58 873 6 0.687285 0.279617 N|NCAPH -0.51332 0 245 0 0 -1.99036 5.188144 81 397|2912 Processes |UHRF1| 8|55112 WDR60 ALDH1A3 220|1381| |CRABP1| 1382|154 CRABP2| GO GO:00161 5|2239|60 CYP1B1|G 1 -1.7378 M1 1 0 Biological 19 diterpenoid metabolic process -1.7378 2.263918 2.572674 24156 110 873 9 1.030928 0.341867 -0.50673 0 131 0 0 -3.08989 10.37629 01 17|8854|9 PC4|RLBP Processes 249|1575 1|ALDH1 06 A2|DHRS 3|RDH10 GO 11004|24 KIF2C|GA GO:19907 Cellular 6176|259 S2L2|ASP 1 -1.52018 M1 1 0 20 microtubule end -1.52018 3.353952 2.620174 24156 33 873 4 0.45819 0.22857 -0.36544 0 300 1 1 -1.52018 3.353952 52 Compone 266|3441 M|NCKAP nts 48 5 ACTN1|A 87|88|215 CTN2|F8| 7|2277|23 VEGFD|F 35|2814|3 N1|GP5|IT 690|5175| GB3|PEC R-HSA- Reactome Platelet activation, signaling and 5321|691 AM1|PLA 1 -1.52003 M1 1 0 6 -1.52003 1.683352 2.157637 24156 263 873 16 1.832761 0.453972 -0.36544 0 81 0 0 -3.97669 6.510612 76002 Gene Sets aggregation 5|7057|70 2G4A|TBX 78|10125| A2R|THBS 10184|94 1|TIMP3|R 121|1391 ASGRP1|L 89 HFPL2|SY TL4|DGKK ACTN2|C 88|1240|1 MKLR1|D GO 816|2840| RD5|GPR GO:00072 phospholipase C-activating G protein- 1 -1.7378 M1 1 0 Biological 19 -1.7378 2.263918 2.572674 24156 110 873 9 1.030928 0.341867 2846|326 17|LPAR4| -0.50673 0 280 1 1 -1.7378 2.263918 00 coupled receptor signaling pathway Processes 9|3357|48 HRH1|HT 83|6869 R2B|NPR3 |TACR1 FAS|STO M|EPHB1| 355|2040| GPM6B|IT 2047|282 GA1|PDZ 4|3672|51 K1|PECA 74|5175|5 M1|PODX GO 420|7132| L|TNFRSF GO:00988 Cellular 7133|722 1 -1.51945 M1 1 0 20 membrane microdomain -1.51945 1.602841 2.128567 24156 328 873 19 2.176403 0.493838 1A|TNFRS -0.36531 0 299 0 0 -1.53107 1.607743 57 Compone 3|8772|23 F1B|TRPC nts 213|2323 4|FADD|S 7|23433|5 ULF1|ARC 5824|647 |RHOQ|P 50|81930| AG1|SMU 83483 RF2|KIF18 A|PLVAP GO AGTR2|C GO:00722 186|947|5 1 -1.73216 M1 1 0 Biological 19 metanephric glomerulus development -1.73216 5.188144 3.244921 24156 16 873 3 0.343643 0.198061 D34|PDG -0.50405 0 119 0 0 -3.27941 18.44674 24 156 Processes FRA ADORA2 GO 135|1007| A|CDH9|C GO:00988 Cellular intrinsic component of presynaptic 1008|113 DH10|CH 1 -1.51582 M1 1 0 20 -1.51582 2.333623 2.356667 24156 83 873 7 0.801833 0.301847 -0.36236 0 58 0 0 -4.67369 3.739203 89 Compone membrane 1|2048|22 RM3|EPH nts 39|2913 B2|GPC4| GRM3 GO EPHB1|CX GO:00509 detection of temperature stimulus involved 2047|638 1 -1.73216 M1 1 0 Biological 19 -1.73216 5.188144 3.244921 24156 16 873 3 0.343643 0.198061 CL12|CXC -0.50405 0 151 0 0 -2.8845 27.6701 65 in sensory perception of pain 7|7852 Processes R4 CPM|CPN 1368|136 1|MMP1| 9|4312|43 MMP7|TL 16|7093|9 L2|ADAM GO GO:00082 508|1117 TS3|ADA 1 -1.51106 M1 1 0 Molecular 21 metallopeptidase activity -1.51106 1.844674 2.202561 24156 180 873 12 1.37457 0.394068 -0.36035 0 88 0 0 -3.79065 3.532354 37 4|57486|6 MTS6|NL Functions 4066|791 N|MMP2 48|17069 7|MMP28 2|206338 |ADAMTS 18|LVRN XIAP|FAS| 331|355|2 GAS2|LM 620|4001| NB1|PMA 5366|702 IP1|TFDP R-HSA- Reactome 9|8655|87 1 -1.51106 M1 1 0 6 Apoptosis -1.51106 1.844674 2.202561 24156 180 873 12 1.37457 0.394068 2|DYNLL1 -0.36035 0 141 0 0 -2.97821 18.44674 109581 Gene Sets 43|8772|6 |TNFSF10| 3967|904 FADD|CLS 27|10050 PN|BMF| 6658 OCLN CCND2|E 894|2078| RG|FLI1| 2313|420 MEF2C|M 8|4233|50 ET|PAX7| KEGG 81|6258|6 1 -1.51106 hsa05202 M1 1 0 24 Transcriptional misregulation in cancer -1.51106 1.844674 2.202561 24156 180 873 12 1.37457 0.394068 RXRG|SPI -0.36035 0 301 1 1 -1.51106 1.844674 Pathway 692|6935| NT1|ZEB1 8357|854 |H3C10|S 14|65360 LC45A3|H 4 3C13 GO BMP7|SU GO:00605 655|2321 1 -1.73216 M1 1 0 Biological 19 morphogenesis of an epithelial bud -1.73216 5.188144 3.244921 24156 16 873 3 0.343643 0.198061 LF1|RDH1 -0.50405 0 153 0 0 -2.8845 27.6701 72 3|157506 Processes 0 GO GO:00019 2324|562 FLT4|PRO 1 -1.73216 M1 1 0 Biological 19 lymphangiogenesis -1.73216 5.188144 3.244921 24156 16 873 3 0.343643 0.198061 -0.50405 0 196 0 0 -2.41795 18.44674 46 9|147372 X1|CCBE1 Processes GO GO:00514 3976|727 LIF|TTK|T 1 -1.73216 M1 1 0 Biological 19 negative regulation of meiotic cell cycle -1.73216 5.188144 3.244921 24156 16 873 3 0.343643 0.198061 -0.50405 0 217 0 0 -2.20452 9.223368 47 2|9319 RIP13 Processes GO 126731|2 CCSAP|G GO:00033 1 -1.73216 M1 1 0 Biological 19 regulation of cilium movement -1.73216 5.188144 3.244921 24156 16 873 3 0.343643 0.198061 46176|33 AS2L2|CC -0.50405 0 235 0 0 -2.09129 7.905744 52 Processes 9829 DC39 CHRNA1| GABRA2| 1134|255 GABRA3| 5|2556|25 GABRA4| 57|2565|2 GABRG1| 890|2902| GRIA1|GR 3739|375 GO IN1|KCNA 9|3762|63 GO:19903 Cellular 4|KCNJ2| 1 -1.50792 M1 1 0 20 transporter complex -1.50792 1.597969 2.114625 24156 329 873 19 2.176403 0.493838 28|7223|9 -0.36035 0 97 0 0 -3.64921 2.294594 51 Compone KCNJ5|SC 312|1036 nts N3A|TRP 9|22871|5 C4|KCNB 5013|126 2|CACNG 755|1965 2|NLGN1| 27|37556 MCUB|LR 7 RC38|AN O6|VWC2 STOM|PT 2040|579 PRJ|TNFR 5|7133|22 SF1B|CD9 GO 918|5491 3|CMTM6 GO:00425 Cellular 8|79895|8 1 -1.50744 M1 1 0 20 specific granule -1.50744 1.90232 2.21739 24156 160 873 11 1.260023 0.37751 |ATP8B4| -0.36035 0 161 0 0 -2.78242 3.040671 81 Compone 0184|816 CEP290|T nts 19|84329| SPAN14| 196527|4 HVCN1|A 01258 NO6|RAB AGTR2|E 186|1907| DN2|EDN 1908|416 3|MC5R| 1|4886|51 NPY1R|PE R-HSA- Reactome 79|6387|6 1 -1.50397 M1 1 0 6 Peptide ligand-binding receptors -1.50397 1.789609 2.176722 24156 201 873 13 1.489118 0.40992 NK|CXCL -0.36035 0 94 0 0 -3.67332 2.548562 375276 Gene Sets 869|7852| 12|TACR1 50865|51 |CXCR4|H 554|5748 EBP1|ACK 6|729230 R4|NLN|C FAS|CAM 355|815|1 K2A|CNN 266|2902| 3|GRIN1|I 3706|415 TPKA|MB GO GO:00055 5|5116|51 P|PCNT|P 1 -1.50397 M1 1 0 Molecular 21 calmodulin binding -1.50397 1.789609 2.176722 24156 201 873 13 1.489118 0.40992 -0.36035 0 302 1 1 -1.50397 1.789609 16 21|10788| CP4|IQGA Functions 27133|53 P2|KCNH 904|5717 5|MYO3A 2|259266 |CAMK1G |ASPM GO GO:00327 1266|713 CNN3|TN 1 -1.73216 M1 1 0 Biological 19 negative regulation of ATPase activity -1.73216 5.188144 3.244921 24156 16 873 3 0.343643 0.198061 -0.50405 0 245 0 0 -1.99036 5.188144 80 9|9104 NT2|RGN Processes GO 10491|30 CRTAP|ER GO:00195 1 -1.73216 M1 1 0 Biological 19 peptidyl-proline hydroxylation -1.73216 5.188144 3.244921 24156 16 873 3 0.343643 0.198061 001|5521 O1A|P3H -0.50405 0 281 1 1 -1.73216 5.188144 11 Processes 4 2 57165|57 GJC2|GJD R-HSA- Reactome 369|7986 2|TUBAL3 1 -1.50382 M1 1 0 6 Gap junction trafficking and regulation -1.50382 2.82348 2.474108 24156 49 873 5 0.572738 0.255402 -0.36035 0 241 0 0 -2.04229 3.84307 157858 Gene Sets 1|81027|2 |TUBB1|G 19770 JD4 2173|328 FABP7|HE R-HSA- Reactome 0|9787|10 S1|DLGAP 1 -1.50382 M1 1 0 6 Signaling by NOTCH3 -1.50382 2.82348 2.474108 24156 49 873 5 0.572738 0.255402 -0.36035 0 303 1 1 -1.50382 2.82348 9012852 Gene Sets 460|5456 5|TACC3| 7 DLL4 BRCA1|LI 672|3976| F|SMAD4| GO 4089|556 GO:19019 PRKAA2|P 1 -1.73038 M1 1 0 Biological 19 regulation of protein acetylation -1.73038 2.582543 2.657909 24156 75 873 7 0.801833 0.301847 3|10891|8 -0.5028 0 184 0 0 -2.53893 6.917526 83 PARGC1A Processes 5459|936 |CEP295| 49 MYOCD 1385|181 CREB1|DR GO 6|2902|32 D5|GRIN1 GO:00083 1 -1.73038 M1 1 0 Biological 19 associative learning -1.73038 2.582543 2.657909 24156 75 873 7 0.801833 0.301847 69|4885|1 |HRH1|NP -0.5028 0 214 0 0 -2.21248 4.19244 06 Processes 1346|164 TX2|SYNP 312 O|LRRN4 CRABP1| GO 1381|158 CYP11A1| GO:00067 1 -1.72461 M1 1 0 Biological 19 fat-soluble vitamin metabolic process -1.72461 3.217454 2.818087 24156 43 873 5 0.572738 0.255402 3|1591|60 CYP24A1| -0.4981 0 173 0 0 -2.66202 6.917526 75 Processes 17|8854 RLBP1|AL DH1A2 2535|328 FZD2|HES GO GO:00601 0|9497|64 1|SLC4A7| 1 -1.72461 M1 1 0 Biological 19 inner ear receptor cell development -1.72461 3.217454 2.818087 24156 43 873 5 0.572738 0.255402 -0.4981 0 240 0 0 -2.05201 6.917526 19 072|1175 CDH23|T Processes 31 MC1 CORUM:1 2187|218 FANCB|F 1 -1.50026 M1 1 0 CORUM 33 FA complex (Fanconi anemia complex) -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 44 0 0 -5.52611 9.223368 152 8 ANCF THBS1|RA 7057|102 MP2|YAP 66|10413| GO 1|PPARG GO:19040 regulation of epithelial cell apoptotic 10891|28 1 -1.71354 M1 1 0 Biological 19 -1.71354 2.380224 2.582304 24156 93 873 8 0.91638 0.322501 C1A|RGC -0.48784 0 253 0 0 -1.94359 4.427216 35 process 984|5112 Processes C|ANGPT 9|196527| L4|ANO6| 641700 ECSCR ALK|BMP 7|CRABP2 238|655|1 |FN1|GOL 382|2335| GA4|ITPK 2803|370 A|NTRK3| 6|4916|55 PRKD1|C GO 87|6387|6 GO:00109 positive regulation of neuron projection XCL12|SKI 1 -1.71179 M1 1 0 Biological 19 -1.71179 1.711553 2.364635 24156 291 873 18 2.061856 0.480948 498|7074| -0.48729 0 29 0 0 -6.42481 3.074456 76 development L|TIAM1| Processes 7852|942 CXCR4|N 3|11141|2 TN1|IL1R 2871|270 APL1|NLG 63|15183 N1|ANKR 5|285016 D1|CPNE 9|ALKAL2 KEGG 5167|516 ENPP1|E 1 -1.50026 hsa00740 M1 1 0 24 Riboflavin metabolism -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 73 0 0 -4.32747 27.6701 Pathway 9 NPP3 MRE11|C 4361|913 GO CNE2|PTT GO:00451 4|9232|93 1 -1.71167 M1 1 0 Biological 19 homologous chromosome segregation -1.71167 2.813909 2.701165 24156 59 873 6 0.687285 0.279617 G1|TRIP1 -0.48729 0 9 0 0 -10.3048 5.16914 43 19|55706| Processes 3|NDC1|S 84690 PATA22 Canonical CDK1|WE 1 -1.50026 M10154 M1 1 0 11 SA G2 AND M PHASES -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 983|7465 -0.36035 0 110 0 0 -3.35124 18.44674 Pathways E1 186|2247| AGTR2|F GO GO:00016 branching involved in ureteric bud 4089|522 GF2|SMA 1 -1.71167 M1 1 0 Biological 19 -1.71167 2.813909 2.701165 24156 59 873 6 0.687285 0.279617 -0.48729 0 10 0 0 -10.1376 3.952872 58 morphogenesis 8|10736|3 D4|PGF|SI Processes 0812 X2|SOX8 AGTR2|C 186|983|1 GO DK1|ECT2 GO:00423 894|2996 1 -1.71167 M1 1 0 Biological 19 regulation of protein import into nucleus -1.71167 2.813909 2.701165 24156 59 873 6 0.687285 0.279617 |MDFIC|R -0.48729 0 224 0 0 -2.14044 2.813909 06 9|51715|8 Processes AB23|EFC 4455 AB7 FZD2|HES 2535|328 GO 1|MYCL|S GO:00601 0|4610|94 1 -1.71167 M1 1 0 Biological 19 inner ear receptor cell differentiation -1.71167 2.813909 2.701165 24156 59 873 6 0.687285 0.279617 LC4A7|CD -0.48729 0 240 0 0 -2.05201 6.917526 13 97|64072| Processes H23|TMC 117531 1 GO 6790|548 AURKA|N GO:00516 1 -1.70748 M1 1 0 Biological 19 centrosome localization -1.70748 3.816566 2.938722 24156 29 873 4 0.45819 0.22857 20|55171| DE1|TBCC -0.48577 0 80 0 0 -4.01173 9.223368 42 Processes 259266 D1|ASPM GO GO:00432 Cellular 6790|229 AURKA|T 1 -1.50026 M1 1 0 20 axon hillock -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 128 0 0 -3.12886 18.44674 03 Compone 74 PX2 nts GO ALDH1A3 GO:00017 1 -1.50026 M1 1 0 Molecular 21 retinal dehydrogenase activity -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 220|8854 |ALDH1A -0.36035 0 131 0 0 -3.08989 10.37629 58 Functions 2 R-HSA- Reactome 8743|877 TNFSF10| 1 -1.50026 M1 1 0 6 TRAIL signaling -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 141 0 0 -2.97821 18.44674 75158 Gene Sets 2 FADD

R-HSA- Reactome Regulation of cytoskeletal remodeling and ACTN1|P 1 -1.50026 M1 1 0 6 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 87|29780 -0.36035 0 143 0 0 -2.96836 6.917526 446388 Gene Sets cell spreading by IPP complex components ARVB GO 4060|496 LUM|OG GO:00181 1 -1.70748 M1 1 0 Biological 19 keratan sulfate biosynthetic process -1.70748 3.816566 2.938722 24156 29 873 4 0.45819 0.22857 9|11081|9 N|KERA|B -0.48577 0 96 0 0 -3.66151 10.37629 46 Processes 3010 3GNT7 CDKN2B| GO 1030|408 GO:00305 positive regulation of transforming growth SMAD4|T 1 -1.70748 M1 1 0 Biological 19 -1.70748 3.816566 2.938722 24156 29 873 4 0.45819 0.22857 9|7057|93 -0.48577 0 136 0 0 -3.0513 3.816566 11 factor beta receptor signaling pathway HBS1|MY Processes 649 OCD CDKN2B| GO 1030|408 GO:19038 positive regulation of cellular response to SMAD4|T 1 -1.70748 M1 1 0 Biological 19 -1.70748 3.816566 2.938722 24156 29 873 4 0.45819 0.22857 9|7057|93 -0.48577 0 136 0 0 -3.0513 3.816566 46 transforming growth factor beta stimulus HBS1|MY Processes 649 OCD GO 1841|185 DTYMK|D GO:00159 nucleobase-containing small molecule 1 -1.70748 M1 1 0 Biological 19 -1.70748 3.816566 2.938722 24156 29 873 4 0.45819 0.22857 4|6241|72 UT|RRM2| -0.48577 0 266 0 0 -1.88377 7.905744 49 interconversion Processes 96 TXNRD1 GO GO:00055 Cellular 2335|705 FN1|THBS 1 -1.50026 M1 1 0 20 fibrinogen complex -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 163 0 0 -2.77297 7.905744 77 Compone 7 1 nts GO 22974|54 TPX2|ND GO:00070 1 -1.70748 M1 1 0 Biological 19 microtubule nucleation -1.70748 3.816566 2.938722 24156 29 873 4 0.45819 0.22857 820|5512 E1|CEP19 -0.48577 0 282 1 1 -1.70748 3.816566 20 Processes 5|55835 2|CENPJ GO 2620|391 GAS2|LA GO:00717 1 -1.70748 M1 1 0 Biological 19 basement membrane organization -1.70748 3.816566 2.938722 24156 29 873 4 0.45819 0.22857 4|10266|2 MB3|RAM -0.48577 0 283 1 1 -1.70748 3.816566 11 Processes 3768 P2|FLRT2 R-HSA- Reactome 6017|924 RLBP1|DH 1 -1.50026 M1 1 0 6 The retinoid cycle in cones (daylight vision) -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 173 0 0 -2.66202 6.917526 2187335 Gene Sets 9 RS3 10413|15 YAP1|RD GO GO:00604 epithelial tube branching involved in lung 7506|284 H10|LAM 1 -1.70748 M1 1 0 Biological 19 -1.70748 3.816566 2.938722 24156 29 873 4 0.45819 0.22857 -0.48577 0 284 1 1 -1.70748 7.905744 41 morphogenesis 217|3404 A1|RSPO Processes 19 2 GO GO:00353 9156|993 EXO1|DC 1 -1.50026 M1 1 0 Molecular 21 5'-3' exodeoxyribonuclease activity -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 188 0 0 -2.46134 6.917526 12 7 LRE1A Functions ACTC1|A CTN2|KC 70|88|375 NJ2|KCNJ 9|3762|46 GO 5|MYL1|T GO:00300 32|7135|7 1 -1.70723 M1 1 0 Biological 19 actin filament-based movement -1.70723 2.042759 2.47229 24156 149 873 11 1.260023 0.37751 NNI1|TN -0.48577 0 61 0 0 -4.53228 18.44674 48 136|7139| Processes NI2|TNNT 7140|745 2|TNNT3| 6|22998 WIPF1|LI MCH1 AGTR2|L DLRAD4| 186|753|1 CYP1B1|F 545|2247| GF2|MEF2 4208|579 C|PTPRJ|C 5|6387|64 XCL12|SF 22|6915|7 RP1|TBXA 057|7075| GO 2R|THBS1 GO:20001 9104|108 1 -1.70295 M1 1 0 Biological 19 negative regulation of cell motility -1.70295 1.632225 2.327017 24156 356 873 21 2.405498 0.518571 |TIE1|RGN -0.48175 0 15 0 0 -9.08083 2.73285 46 91|22998| Processes |PPARGC 23213|28 1A|LIMCH 984|5456 1|SULF1|R 7|79148|7 GCC|DLL4 9812|936 |MMP28| 49|13145 MMRN2| 0 MYOCD| CD200R1 AGTR2|F HL1|INHB 186|2273| A|SMAD4 3624|408 |ENPP1|S 9|5167|52 ERPINE2| 70|5600|5 GO MAPK11| GO:00459 795|5931| 1 -1.69861 M1 1 0 Biological 19 negative regulation of growth -1.69861 1.770887 2.372456 24156 250 873 16 1.832761 0.453972 PTPRJ|RB -0.47806 0 104 0 0 -3.44559 2.082696 26 6422|709 Processes BP7|SFRP 3|9423|97 1|TLL2|NT 23|29948| N1|SEMA 84687|85 3E|OSGIN 004 1|PPP1R9 B|RERG FAS|BMP 7|BRCA1| 355|655|6 CAMK2A| 72|815|94 CD34|CD 7|1021|13 K6|CRHB 93|1490|2 P|CCN2|E 047|2122| PHB1|ME 2187|232 COM|FA 4|3090|42 NCB|FLT4 33|4916|5 |HIC1|ME 366|6387| T|NTRK3| 6422|649 PMAIP1|C 8|7074|83 XCL12|SF GO GO:00801 25|8767|9 RP1|SKIL| 1 -1.69604 M1 1 0 Biological 19 regulation of cellular response to stress -1.69604 1.410633 2.234864 24156 765 873 39 4.467354 0.699188 -0.47589 0 262 0 0 -1.9094 4.368964 35 104|1012 TIAM1|FZ Processes 5|10516|2 D8|RIPK2| 5950|261 RGN|RAS 56|27063| GRP1|FBL 29969|54 N5|RWD 780|5501 D3|RSL1D 0|55031|5 1|ANKRD 5137|551 1|MDFIC| 83|55706| NSMCE4 56963|79 A|PARPBP 444|8393 |USP47|FI 3|401720 GN|RIF1| NDC1|RG MA|BIRC7 STOM|EP 2040|204 HB2|GPC 8|2239|39 4|LGALS3| 58|5174|5 PDZK1|P GO 366|7029| MAIP1|TF GO:19054 regulation of protein localization to 1 -1.69479 M1 1 0 Biological 19 -1.69479 1.903235 2.413881 24156 189 873 13 1.489118 0.40992 10369|23 DP2|CAC -0.4749 0 270 0 0 -1.84895 2.110432 75 membrane Processes 433|8445 NG2|RHO 5|84687|9 Q|EFCAB 1461|131 7|PPP1R9 578 B|PKDCC| LRRC15 CORUM:5 1266|400 CNN3|LM 1 -1.50026 M1 1 0 CORUM 33 Emerin complex 1 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 212 0 0 -2.24088 6.917526 604 8 O7 R-HSA- Reactome 2619|916 GAS1|BO 1 -1.50026 M1 1 0 6 Ligand-receptor interactions -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 225 0 0 -2.13258 6.917526 5632681 Gene Sets 53 C CCND2|C 894|983|8 DK1|CDC 317|8318| GO 7|CDC45| GO:19019 positive regulation of cell cycle phase 9787|270 1 -1.69194 M1 1 0 Biological 19 -1.69194 2.22349 2.513028 24156 112 873 9 1.030928 0.341867 DLGAP5| -0.47259 0 51 0 0 -5.22312 2.912642 89 transition 85|28984| Processes MTBP|RG 29766|51 CC|TMO 514 D3|DTL GO GO:00616 Cellular 81930|12 KIF18A|C 1 -1.50026 M1 1 0 20 mitotic spindle astral microtubule -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 235 0 0 -2.09129 7.905744 73 Compone 6731 CSAP nts AGTR2|B 186|580|9 ARD1|CD 83|1894|2 GO K1|ECT2| GO:00468 9969|515 1 -1.69194 M1 1 0 Biological 19 regulation of nucleocytoplasmic transport -1.69194 2.22349 2.513028 24156 112 873 9 1.030928 0.341867 MDFIC|G -0.47259 0 224 0 0 -2.14044 2.813909 22 12|51715| Processes TSE1|RAB 55051|84 23|NRDE2 455 |EFCAB7 GPR17|LP 2840|284 AR4|MET| 6|4233|51 PECAM1| 75|8727|9 GO CTNNAL1 GO:00072 423|1027 1 -1.68801 M1 1 0 Biological 19 Rho protein signal transduction -1.68801 2.029141 2.448227 24156 150 873 11 1.260023 0.37751 |NTN1|NE -0.46891 0 145 0 0 -2.94443 4.19244 66 6|23433|5 Processes T1|RHOQ 0650|573 |ARHGEF 81|15728 3|RHOJ|P 5 RAG1 2247|232 FGF2|FLT 4|3690|42 4|ITGB3| GO 33|5587|5 MET|PRK GO:00105 positive regulation of endothelial cell 1 -1.68515 M1 1 0 Biological 19 -1.68515 2.112222 2.471647 24156 131 873 10 1.145475 0.360151 629|7057| D1|PROX -0.46846 0 15 0 0 -9.08083 2.73285 95 migration Processes 57381|57 1|THBS1| 608|1473 RHOJ|JCA 72 D|CCBE1 1894|745 ECT2|WIP GO GO:00308 6|9493|23 F1|KIF23| 1 -1.68494 M1 1 0 Biological 19 cortical actin cytoskeleton organization -1.68494 3.14433 2.756719 24156 44 873 5 0.572738 0.255402 -0.46846 0 102 0 0 -3.49473 18.44674 66 433|5444 RHOQ|A Processes 3 NLN R-HSA- Reactome RUNX3 regulates YAP1-mediated 1490|104 CCN2|YA 1 -1.50026 M1 1 0 6 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 284 0 0 -1.70748 7.905744 8951671 Gene Sets transcription 13 P1 655|4233| BMP7|ME GO GO:19010 regulation of response to reactive oxygen 9104|105 T|RGN|FB 1 -1.68494 M1 1 0 Biological 19 -1.68494 3.14433 2.756719 24156 44 873 5 0.572738 0.255402 -0.46846 0 120 0 0 -3.26614 6.385408 31 species 16|14368 LN5|SESN Processes 6 3 GO GO:00312 Cellular 8318|553 CDC45|M 1 -1.50026 M1 1 0 20 replication fork protection complex -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 286 0 0 -1.65943 6.917526 98 Compone 88 CM10 nts GO GO:00018 720|2291 C4A|CD9 1 -1.50026 M1 1 0 Molecular 21 complement component C1q binding -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 304 1 1 -1.50026 6.917526 49 8 3 Functions GO GO:00303 54756|40 IL17RD|IL 1 -1.50026 M1 1 0 Molecular 21 interleukin-17 receptor activity -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 305 1 1 -1.50026 6.917526 68 0935 17REL Functions ALDH1A3 GO 220|1545| |CYP1B1| GO:00425 1 -1.68494 M1 1 0 Biological 19 retinol metabolic process -1.68494 3.14433 2.756719 24156 44 873 5 0.572738 0.255402 8854|924 ALDH1A2 -0.46846 0 131 0 0 -3.08989 10.37629 72 Processes 9|157506 |DHRS3|R DH10 AGTR2|C GO 186|1393| GO:00440 RHBP|INH 1 -1.68494 M1 1 0 Biological 19 regulation of endocrine process -1.68494 3.14433 2.756719 24156 44 873 5 0.572738 0.255402 3624|408 -0.46846 0 197 0 0 -2.41795 18.44674 60 BA|SMAD Processes 9|114899 4|C1QTN CP|CREB1 1356|138 |SMAD4|R Canonical 5|4089|60 1 -1.49805 M255 M1 1 0 11 PID HIF1 TFPATHWAY -1.49805 2.515464 2.387208 24156 66 873 6 0.687285 0.279617 ORA|CXC -0.3588 0 178 0 0 -2.59562 18.44674 Pathways 95|6387|7 L12|CXCR 852 4 VCAN|UG 1462|735 GO DH|CHST GO:00506 chondroitin sulfate proteoglycan metabolic 8|51363|5 1 -1.68494 M1 1 0 Biological 19 -1.68494 3.14433 2.756719 24156 44 873 5 0.572738 0.255402 15|CSGAL -0.46846 0 228 0 0 -2.12745 13.83505 54 process 5790|133 Processes NACT1|E 584 GFLAM CCND2|C 894|899|9 CNF|CCN 01|1030|1 G2|CDKN 164|9133| 2B|CKS2| GO GO:00198 9134|289 CCNB2|C 1 -1.49515 M1 1 0 Molecular 21 protein kinase regulator activity -1.49515 1.834482 2.182067 24156 181 873 12 1.37457 0.394068 -0.35632 0 37 0 0 -6.01116 5.929308 87 84|54757| CNE2|RG Functions 54997|85 CC|FAM2 417|2850 0A|TESC| 16 CCNB3|A LKAL2 3280|461 HES1|MY GO GO:00353 0|5308|94 CL|PITX2| 1 -1.68494 M1 1 0 Biological 19 hair cell differentiation -1.68494 3.14433 2.756719 24156 44 873 5 0.572738 0.255402 -0.46846 0 240 0 0 -2.05201 6.917526 15 97|11753 SLC4A7|T Processes 1 MC1 FGF2|VEG 2247|227 FD|FLT4| 7|2324|33 HTR2B|IT 57|3690|5 GB3|PGF| GO 228|5587| GO:00506 positive regulation of epithelial cell PRKD1|PR 1 -1.6814 M1 1 0 Biological 19 -1.6814 1.844674 2.380528 24156 210 873 14 1.603666 0.425147 5629|638 -0.46518 0 68 0 0 -4.38679 2.76701 79 proliferation OX1|CXC Processes 7|6422|10 L12|SFRP 413|5760 1|YAP1|JC 8|116039| AD|OSR2| 441478 NRARP 3958|910 LGALS3|R GO 4|57718|8 GN|PPP4 GO:00325 negative regulation of phosphoprotein 1 -1.67895 M1 1 0 Biological 19 -1.67895 2.76701 2.653587 24156 60 873 6 0.687285 0.279617 4687|849 R4|PPP1R -0.46299 0 199 0 0 -2.40034 2.76701 15 phosphatase activity Processes 30|39261 9B|MAST 7 L|ELFN1 BMP7|FZ 655|2535| GO D2|HES1| GO:00604 3280|408 1 -1.67357 M1 1 0 Biological 19 cardiac septum morphogenesis -1.67357 2.515464 2.579069 24156 77 873 7 0.801833 0.301847 SMAD4|P -0.45866 0 75 0 0 -4.23321 3.816566 11 9|5629|92 Processes ROX1|DH 49|23414 RS3|ZFP ECT2|HTR 2B|ASAP2 1894|335 |USP6NL| 7|8853|97 GIT2|ARH 12|9815|9 GAP11A| 824|9938| ARHGAP2 10788|22 5|IQGAP2 GO 821|2321 GO:00306 |RASA3|T 1 -1.48578 M1 1 0 Molecular 21 GTPase regulator activity -1.48578 1.611851 2.096037 24156 309 873 18 2.061856 0.480948 6|25780|2 -0.34804 0 130 0 0 -3.11246 1.704318 95 BC1D1|R Functions 6037|556 ASGRP3|S 35|55789| IPA1L1|D 57568|85 EPDC1|D 397|2021 EPDC1B|S 51|25552 IPA1L2|R 0 GS8|RAN BP3L|ELM 4361|475 MRE11|N GO 1|5073|75 EK2|PAR GO:00062 1 -1.67357 M1 1 0 Biological 19 RNA-dependent DNA biosynthetic process -1.67357 2.515464 2.579069 24156 77 873 7 0.801833 0.301847 20|54464| N|XRCC5| -0.45866 0 85 0 0 -3.87201 3.458763 78 Processes 80119|80 XRN1|PIF 169 1|CTC1 CHRM3|D 1131|181 GO RD5|EDN GO:00423 6|1907|19 1 -1.67357 M1 1 0 Biological 19 vasoconstriction -1.67357 2.515464 2.579069 24156 77 873 7 0.801833 0.301847 2|EDN3|H -0.45866 0 115 0 0 -3.30059 4.19244 10 08|3269|3 Processes RH1|HTR 357|6915 2B|TBXA2 CHGB|ED 1114|190 N2|EDN3| 7|1908|22 GO FBN1|INH GO:00051 00|3624|5 1 -1.48141 M1 1 0 Molecular 21 hormone activity -1.48141 2.041237 2.232583 24156 122 873 9 1.030928 0.341867 BA|PENK| -0.34433 0 187 0 0 -2.48174 18.44674 79 179|5744| Functions PTHLH|F 252995|7 NDC5|INS 23961 -IGF2 ACTN2|E 88|2048|5 PHB2|PD 174|9104| GO ZK1|RGN| GO:00324 10369|23 1 -1.66951 M1 1 0 Biological 19 positive regulation of transporter activity -1.66951 2.203814 2.483678 24156 113 873 9 1.030928 0.341867 CACNG2| -0.45511 0 45 0 0 -5.5147 9.223368 11 237|5499 Processes ARC|TESC 7|126755| |LRRC38| 729230 CCR2 ADORA2 135|196|9 A|AHR|C 83|1385|4 DK1|CREB 916|5563| 1|NTRK3| GO 5629|609 PRKAA2|P GO:00076 1 -1.66567 M1 1 0 Biological 19 circadian rhythm -1.66567 1.835931 2.361541 24156 211 873 14 1.603666 0.425147 5|7054|71 ROX1|RO -0.45179 0 185 0 0 -2.51915 2.406096 23 Processes 53|10891| RA|TH|TO 22871|50 P2A|PPAR 865|7972 GC1A|NL 3 GN1|HEB P1|SUV39 BMP7|CD 655|947|3 34|INHBA 624|5156| |PDGFRA| GO 5308|104 GO:00424 PITX2|FST 1 -1.66468 M1 1 0 Biological 19 odontogenesis -1.66468 2.09622 2.445418 24156 132 873 10 1.145475 0.360151 68|54757| -0.45132 0 285 1 1 -1.66468 2.09622 76 |FAM20A| Processes 80326|11 WNT10A| 6039|340 OSR2|RSP 419 O2 AGTR2|C 186|1003| DH5|DUS 1849|367 P7|ITGA1| 2|3958|57 LGALS3|P 83|5795|9 TPN13|PT 104|1045 PRJ|RGN| GO 4|11072|2 TAB1|DU GO:00064 1 -1.66412 M1 1 0 Biological 19 protein dephosphorylation -1.66412 1.663709 2.299636 24156 316 873 19 2.176403 0.493838 2843|271 SP14|PP -0.45128 0 199 0 0 -2.40034 2.76701 70 Processes 43|57718| M1E|PAL 84687|84 D1|PPP4R 867|8493 4|PPP1R9 0|93492|1 B|PTPN5| 57313|39 MASTL|T 2617 PTE2|CDC A2|ELFN1 BRCA1|C 672|983|2 DK1|FHL1 GO 273|4361| GO:00109 negative regulation of G2/M transition of |MRE11|O 1 -1.66363 M1 1 0 Biological 19 -1.66363 2.330114 2.515272 24156 95 873 8 0.91638 0.322501 4998|679 -0.45105 0 208 0 0 -2.2632 4.323454 72 mitotic cell cycle RC1|AUR Processes 0|55031|6 KA|USP47 3967 |CLSPN BRCA2|C 675|1021| DK6|CDK 1030|420 N2B|MEF 8|6422|70 GO 2C|SFRP1| GO:00506 negative regulation of epithelial cell 57|9104|2 1 -1.66197 M1 1 0 Biological 19 -1.66197 1.941762 2.393097 24156 171 873 12 1.37457 0.394068 THBS1|RG -0.45097 0 106 0 0 -3.41692 1.941762 80 proliferation 3213|289 Processes N|SULF1| 84|51098| RGCC|IFT 54567|64 52|DLL4|T 102 NMD 4060|496 LUM|OG R-HSA- Reactome 1 -1.47801 M1 1 0 6 Keratan sulfate/keratin metabolism -1.47801 3.255306 2.548176 24156 34 873 4 0.45819 0.22857 9|11081|9 N|KERA|B -0.34267 0 0 1638074 Gene Sets 3010 3GNT7 GO EPHB1|CX GO:00509 detection of temperature stimulus involved 2047|638 1 -1.65943 M1 1 0 Biological 19 -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 CL12|CXC -0.45097 0 151 0 0 -2.8845 27.6701 61 in sensory perception 7|7852 Processes R4 GO 7153|800 GO:00007 resolution of meiotic recombination TOP2A|R 1 -1.65943 M1 1 0 Biological 19 -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 10|14695 -0.45097 0 156 0 0 -2.83533 5.764605 12 intermediates MI1|EME1 Processes 6 ADORA2 GO GO:00310 135|1789| A|DNMT3 1 -1.65943 M1 1 0 Biological 19 response to caffeine -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 -0.45097 0 171 0 0 -2.66202 13.83505 00 10891 B|PPARG Processes C1A ADORA2 GO GO:00362 135|1789| A|DNMT3 1 -1.65943 M1 1 0 Biological 19 response to diuretic -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 -0.45097 0 171 0 0 -2.66202 13.83505 70 10891 B|PPARG Processes C1A GO 51141|51 INSIG2|R GO:00970 1 -1.65943 M1 1 0 Biological 19 craniofacial suture morphogenesis -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 715|1583 AB23|FRE -0.45097 0 179 0 0 -2.59556 4.882959 94 Processes 26 M1 GO XIAP|SLC GO:00550 331|1317| 1 -1.65943 M1 1 0 Biological 19 copper ion homeostasis -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 31A1|SC -0.45097 0 190 0 0 -2.46134 9.223368 70 6341 Processes O1 ASPA|CH 443|1131| RM3|DUS 1849|436 P7|MRE1 1|5073|51 1|PARN|E 67|5169|5 NPP1|EN 321|5395| PP3|PLA2 5783|579 G4A|PMS 5|8483|91 2|PTPN13 04|9156|9 |PTPRJ|CI 317|9388| LP|RGN|E 9563|993 XO1|PTER 7|10454|1 |LIPG|H6P GO 0940|110 D|DCLRE1 GO:00167 1 -1.47265 M1 1 0 Molecular 21 hydrolase activity, acting on ester bonds -1.47265 1.370541 1.99203 24156 747 873 37 4.238259 0.68184 72|22843| A|TAB1|P -0.33951 0 0 88 Functions 23213|27 OP1|DUS 143|5155 P14|PPM 9|54464|5 1E|SULF1| 5344|557 PALD1|N 28|84618| T5DC3|XR 84867|92 N1|PLCX 667|9349 D1|N4BP 2|115752| 2|NT5C1 137902|1 A|PTPN5| 49998|17 MGME1|T 1586|220 PTE2|DIS 032 3L|PXDNL |LIPI|ABH GO ADORA2 GO:00427 135|6095| 1 -1.65943 M1 1 0 Biological 19 positive regulation of circadian rhythm -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 A|RORA| -0.45097 0 202 0 0 -2.32557 4.882959 53 22871 Processes NLGN1 GO ORC1|CD GO:00000 4998|831 1 -1.65943 M1 1 0 Biological 19 DNA replication checkpoint -1.65943 4.882959 3.101122 24156 17 873 3 0.343643 0.198061 C45|CLSP -0.45097 0 286 1 1 -1.65943 6.917526 76 8|63967 Processes N GO 6790|548 AURKA|N GO:00618 1 -1.65759 M1 1 0 Biological 19 microtubule organizing center localization -1.65759 3.689347 2.854013 24156 30 873 4 0.45819 0.22857 20|55171| DE1|TBCC -0.45092 0 80 0 0 -4.01173 9.223368 42 Processes 259266 D1|ASPM GO 672|3976| BRCA1|LI GO:00350 1 -1.65759 M1 1 0 Biological 19 positive regulation of histone acetylation -1.65759 3.689347 2.854013 24156 30 873 4 0.45819 0.22857 4089|108 F|SMAD4| -0.45092 0 184 0 0 -2.53893 6.917526 66 Processes 91 PPARGC1 GO 4883|642 NPR3|SFR GO:00336 1 -1.65759 M1 1 0 Biological 19 regulation of osteoblast proliferation -1.65759 3.689347 2.854013 24156 30 873 4 0.45819 0.22857 2|10516|3 P1|FBLN5| -0.45092 0 234 0 0 -2.0944 3.952872 88 Processes 0812 SOX8 ACTN2|C 88|1393|2 RHBP|ST 040|2048| OM|EPHB 2273|289 2|FHL1|G 0|2902|42 RIA1|GRI GO 08|5174|9 N1|MEF2 GO:00228 regulation of transmembrane transporter 1 -1.6561 M1 1 0 Biological 19 -1.6561 1.716758 2.310488 24156 274 873 17 1.947308 0.467671 104|1036 C|PDZK1| -0.44968 0 45 0 0 -5.5147 9.223368 98 activity Processes 9|10891|2 RGN|CAC 2871|232 NG2|PPA 37|54997| RGC1A|N 126755|7 LGN1|AR 29230 C|TESC|LR RC38|CCR GABRA2| GO 2555|255 GABRA3| GO:00347 Cellular 6|2557|25 1 -1.4707 M1 1 0 20 chloride channel complex -1.4707 2.76701 2.42188 24156 50 873 5 0.572738 0.255402 GABRA4| -0.33951 0 0 07 Compone 65|19652 GABRG1| nts 7 ANO6 GRIA1|HT 2890|335 R2B|ITGB 7|3690|64 GO 3|SH3GL2 GO:00316 56|6642|1 1 -1.6474 M1 1 0 Biological 19 receptor internalization -1.6474 2.184482 2.454634 24156 114 873 9 1.030928 0.341867 |SNX1|RA -0.44185 0 288 1 1 -1.6474 3.570336 23 0266|103 Processes MP2|CAC 69|23237| NG2|ARC| 347730 LRRTM1 FN1|GOL GO 2335|280 GO:00457 GA4|NTR 1 -1.64649 M1 1 0 Biological 19 positive regulation of axon extension -1.64649 3.074456 2.697081 24156 45 873 5 0.572738 0.255402 3|4916|63 -0.44185 0 29 0 0 -6.42481 3.074456 73 K3|CXCL1 Processes 87|9423 2|NTN1 GO ACTN1|A 87|88|215 GO:00310 Cellular CTN2|F8| 1 -1.47026 M1 1 0 20 platelet alpha granule lumen -1.47026 2.47792 2.345687 24156 67 873 6 0.687285 0.279617 7|2277|23 -0.33951 0 0 93 Compone VEGFD|F 35|7057 nts N1|THBS1 ACTL6A| 86|3015|8 GO H2AZ1|EE GO:00314 726|9324| 1 -1.47026 M1 1 0 Molecular 21 nucleosome binding -1.47026 2.47792 2.345687 24156 67 873 6 0.687285 0.279617 D|HMGN -0.33951 0 0 91 29128|79 Functions 3|UHRF1| 366 HMGN5 FZD2|HES GO 2535|328 GO:00604 1|SMAD4| 1 -1.64649 M1 1 0 Biological 19 ventricular septum morphogenesis -1.64649 3.074456 2.697081 24156 45 873 5 0.572738 0.255402 0|4089|56 -0.44185 0 75 0 0 -4.23321 3.816566 12 PROX1|ZF Processes 29|23414 PM2 ITGA2|SE 3673|527 GO RPINE2|C GO:00509 0|6387|78 1 -1.64649 M1 1 0 Biological 19 detection of mechanical stimulus -1.64649 3.074456 2.697081 24156 45 873 5 0.572738 0.255402 XCL12|CX -0.44185 0 151 0 0 -2.8845 27.6701 82 52|11753 Processes CR4|TMC 1 1 1003|423 CDH5|ME 3|22974|5 GO T|TPX2|N GO:00467 4820|551 1 -1.646 M1 1 0 Biological 19 microtubule polymerization -1.646 2.483214 2.540576 24156 78 873 7 0.801833 0.301847 DE1|CEP1 -0.44161 0 282 0 0 -1.70748 3.816566 85 25|55835| Processes 92|CENPJ| 10050665 OCLN 8 CDH11|E 1009|204 PHB1|EP 7|2048|32 HB2|HES1 80|3624|5 GO |INHBA|P GO:00219 central nervous system neuron 081|5629| 1 -1.64499 M1 1 0 Biological 19 -1.64499 1.873497 2.353008 24156 192 873 13 1.489118 0.40992 AX7|PRO -0.44086 0 177 0 0 -2.61606 2.019716 53 differentiation 6095|642 Processes X1|RORA| 2|8543|26 SFRP1|LM 468|5456 O4|LHX6| 7|85442 DLL4|KN GO ENPP1|E GO:00045 5167|516 1 -1.46969 M1 1 0 Molecular 21 nucleotide diphosphatase activity -1.46969 4.150515 2.729324 24156 20 873 3 0.343643 0.198061 NPP3|CIL -0.33951 0 0 51 9|8483 Functions P VCAN|CH R-HSA- Reactome 1462|513 1 -1.46969 M1 1 0 6 Chondroitin sulfate biosynthesis -1.46969 4.150515 2.729324 24156 20 873 3 0.343643 0.198061 ST15|CSG -0.33951 0 0 2022870 Gene Sets 63|55790 ALNACT1 NTRK3|IL R-HSA- Reactome Receptor-type tyrosine-protein 4916|111 1 -1.46969 M1 1 0 6 -1.46969 4.150515 2.729324 24156 20 873 3 0.343643 0.198061 1RAPL1|IL -0.33951 0 0 388844 Gene Sets phosphatases 41|26280 1RAPL2 BMP7|GP 655|2882| X7|HBA1| 3039|574 PTGS1|TX GO 2|7296|91 GO:00987 NRD1|RG 1 -1.64446 M1 1 0 Biological 19 detoxification -1.64446 2.080459 2.419422 24156 133 873 10 1.145475 0.360151 04|10516| -0.44058 0 120 0 0 -3.26614 6.385408 54 N|FBLN5| Processes 10587|13 TXNRD2| 7902|140 PXDNL|S 809 RXN1 ECT2|HTR 2B|NTRK3 1894|335 |SFRP1|TI 7|4916|64 AM1|ASA 22|7074|8 P2|RGN|U 853|9104| SP6NL|GI 9712|981 T2|ARHG 5|9824|99 AP11A|A 38|10125| RHGAP25 GO GO:00435 10276|22 |RASGRP1 1 -1.644 M1 1 0 Biological 19 positive regulation of GTPase activity -1.644 1.571389 2.24548 24156 405 873 23 2.634593 0.542066 -0.44038 0 130 0 0 -3.11246 1.704318 47 821|2321 |NET1|RA Processes 6|25780|2 SA3|TBC1 6037|556 D1|RASG 35|55789| RP3|SIPA 57568|85 1L1|DEPD 397|2021 C1|DEPD 51|25552 C1B|SIPA 0 1L2|RGS8| RANBP3L| ELMOD2 655|4208| BMP7|ME 5156|693 F2C|PDGF GO GO:00487 5|10736|5 RA|ZEB1| 1 -1.63929 M1 1 0 Biological 19 embryonic skeletal system morphogenesis -1.63929 2.305842 2.482388 24156 96 873 8 0.91638 0.322501 -0.43617 0 11 0 0 -10.1305 3.03234 04 5112|116 SIX2|WDR Processes 039|1575 60|OSR2| 06 RDH10 2902|370 GRIN1|IT 6|7074|11 PKA|TIAM GO GO:00488 141|2287 1|IL1RAPL 1 -1.63929 M1 1 0 Biological 19 regulation of dendrite morphogenesis -1.63929 2.305842 2.482388 24156 96 873 8 0.91638 0.322501 -0.43617 0 107 0 0 -3.41128 3.074456 14 1|23237|2 1|NLGN1| Processes 6037|854 ARC|SIPA 42 1L1|KND ADORA2 A|ADORA 2B|AGTR2 135|136|1 |CD34|CR 86|947|13 EB1|EDN3 85|1908|3 |HTR2B|I 357|3624| NHBA|SM 4089|415 AD4|MBP| 5|5600|63 GO MAPK11| GO:19035 87|8111|8 1 -1.63314 M1 1 0 Biological 19 positive regulation of secretion by cell -1.63314 1.567518 2.233069 24156 406 873 23 2.634593 0.542066 CXCL12|G -0.43027 0 133 0 0 -3.08066 2.143459 32 767|1012 Processes PR68|RIP 5|10631|2 K2|RASGR 2871|230 P1|POST 86|27063| N|NLGN1 28984|79 |EXPH5|A 679|9412 NKRD1|R 1|114899 GCC|VTC N1|SYTL4| C1QTNF3 BRCA2|C 675|835|9 ASP2|CD 83|1021|1 K1|CDK6| 030|1385| CDKN2B| 1490|386 CREB1|CC 1|4017|43 N2|KRT14 GO GO:00075 16|5179|7 |LOXL2|M 1 -1.62685 M1 1 0 Biological 19 aging -1.62685 1.648063 2.2562 24156 319 873 19 2.176403 0.493838 -0.42996 0 289 1 1 -1.62685 1.648063 68 054|7133| MP7|PEN Processes 9104|108 K|TH|TNF 91|26156| RSF1B|RG 30001|80 N|PPARG 169|8468 C1A|RSL1 7 D1|ERO1 A|CTC1|P 1870|705 E2F2|THB 7|10266|1 S1|RAMP GO 0413|108 2|YAP1|P GO:19040 1 -1.6256 M1 1 0 Biological 19 epithelial cell apoptotic process -1.6256 2.165486 2.425889 24156 115 873 9 1.030928 0.341867 91|28984| PARGC1A -0.42996 0 253 0 0 -1.94359 4.427216 19 Processes 51129|19 |RGCC|A 6527|641 NGPTL4| 700 ANO6|EC AGTR2|L DLRAD4| 186|753|1 CYP1B1|F 545|2247| GF2|MEF2 4208|579 C|PTPRJ|C 5|6387|64 XCL12|SF 22|6915|7 RP1|TBXA GO 057|7075| GO:00303 2R|THBS1 1 -1.62294 M1 1 0 Biological 19 negative regulation of cell migration -1.62294 1.62288 2.243094 24156 341 873 20 2.290951 0.50637 10891|22 -0.42996 0 15 0 0 -9.08083 2.73285 36 |TIE1|PPA Processes 998|2321 RGC1A|LI 3|28984|5 MCH1|SU 4567|791 LF1|RGCC 48|79812| |DLL4|M 93649|13 MP28|M 1450 MRN2|M YOCD|CD ESRRB|HR 2103|326 H1|ENPP 9|5167|91 1|RGN|HS 04|9653|1 2ST1|PPA 0891|231 RGC1A|P GO GO:00160 78|51363| ASK|CHST 1 -1.61932 M1 1 0 Biological 19 carbohydrate biosynthetic process -1.61932 1.810194 2.30519 24156 214 873 14 1.603666 0.425147 -0.42996 0 251 0 0 -1.95287 3.29406 51 51477|55 15|ISYNA Processes 790|5748 1|CSGAL 6|93010|1 NACT1|N 14899|33 LN|B3GN 8596 T7|C1QT NF3|ST8SI EPHB1|EP 2047|204 HB2|HES1 GO 8|3280|49 GO:00216 |NRTN|SE 1 -1.61896 M1 1 0 Biological 19 nerve development -1.61896 2.451781 2.502677 24156 79 873 7 0.801833 0.301847 02|5270|2 -0.42996 0 126 0 0 -3.20893 9.223368 75 RPINE2|S Processes 3213|845 ULF1|COL 70 25A1 BMP7|LD 655|753|3 GO LRAD4|IN GO:00603 regulation of pathway-restricted SMAD 624|4089| 1 -1.61581 M1 1 0 Biological 19 -1.61581 2.677752 2.561299 24156 62 873 6 0.687285 0.279617 HBA|SMA -0.42996 0 84 0 0 -3.88473 11.06804 93 protein phosphorylation 7272|569 Processes D4|TTK|P 37 MEPA1 GP5|ITGA 2814|367 2|ITGB3|P 3|3690|53 LA2G4A|P KEGG 21|5593|5 RKG2|MA 1 -1.46194 hsa04611 M1 1 0 24 Platelet activation -1.46194 2.024642 2.206032 24156 123 873 9 1.030928 0.341867 -0.33432 0 0 Pathway 600|5742| PK11|PTG 6915|101 S1|TBXA2 25 R|RASGR P1 4751|507 NEK2|PA GO GO:19043 regulation of telomere maintenance via 3|7520|54 RN|XRCC 1 -1.61581 M1 1 0 Biological 19 -1.61581 2.677752 2.561299 24156 62 873 6 0.687285 0.279617 -0.42996 0 85 0 0 -3.87201 3.458763 56 telomere lengthening 464|8011 5|XRN1|PI Processes 9|80169 F1|CTC1 BMP7|SM 655|4089| GO AD4|SMA GO:00098 4090|422 1 -1.61581 M1 1 0 Biological 19 embryonic pattern specification -1.61581 2.677752 2.561299 24156 62 873 6 0.687285 0.279617 D5|MEOX -0.42996 0 153 0 0 -2.8845 27.6701 80 2|6491|44 Processes 1|STIL|NR 1478 ARP ECT2|ITPK 1894|370 A|TIAM1| 6|7074|10 NET1|IQG GO 276|1078 GO:00170 AP2|STXB 1 -1.45576 M1 1 0 Molecular 21 Rho GTPase binding -1.45576 1.934972 2.171374 24156 143 873 10 1.145475 0.360151 8|29091|2 -0.32878 0 0 48 P6|PKN3| Functions 9941|506 ARHGEF3 50|54443| |ANLN|PA 84612 RD6B BRCA1|LI 672|3976| GO F|SMAD4| GO:20007 4089|556 1 -1.61581 M1 1 0 Biological 19 regulation of peptidyl-lysine acetylation -1.61581 2.677752 2.561299 24156 62 873 6 0.687285 0.279617 PRKAA2|P -0.42996 0 184 0 0 -2.53893 6.917526 56 3|10891|9 Processes PARGC1A 3649 |MYOCD AGTR2|C 186|983|1 GO DK1|ECT2 GO:19045 894|2996 1 -1.61581 M1 1 0 Biological 19 regulation of protein import -1.61581 2.677752 2.561299 24156 62 873 6 0.687285 0.279617 |MDFIC|R -0.42996 0 224 0 0 -2.14044 2.813909 89 9|51715|8 Processes AB23|EFC 4455 AB7 2535|289 FZD2|GRI GO 0|5174|83 A1|PDZK1 GO:00301 1 -1.4434 M1 1 0 Molecular 21 PDZ domain binding -1.4434 2.252218 2.25259 24156 86 873 7 0.801833 0.301847 25|9928|2 |FZD8|KIF -0.318 0 0 65 Functions 2871|542 14|NLGN 21 1|SNTG2 CREB1|D 1385|184 USP7|ME 9|4208|42 R-HSA- Reactome F2C|MAP 1 -1.4434 M1 1 0 6 Toll Like Receptor 10 (TLR10) Cascade -1.4434 2.252218 2.25259 24156 86 873 7 0.801833 0.301847 14|5600|8 -0.318 0 0 168142 Gene Sets 3K1|MAP 767|1045 K11|RIPK2 4 |TAB1 CREB1|D 1385|184 USP7|ME 9|4208|42 R-HSA- Reactome F2C|MAP 1 -1.4434 M1 1 0 6 Toll Like Receptor 5 (TLR5) Cascade -1.4434 2.252218 2.25259 24156 86 873 7 0.801833 0.301847 14|5600|8 -0.318 0 0 168176 Gene Sets 3K1|MAP 767|1045 K11|RIPK2 4 |TAB1 BRCA1|BR 672|675|3 CA2|H2A 015|4361| R-HSA- Reactome Z1|MRE1 1 -1.4434 M1 1 0 6 Meiotic recombination -1.4434 2.252218 2.25259 24156 86 873 7 0.801833 0.301847 8357|840 -0.318 0 0 912446 Gene Sets 1|H3C10| 57|65360 MND1|H3 4 C13 CREB1|D 1385|184 USP7|ME 9|4208|42 R-HSA- Reactome MyD88 cascade initiated on plasma F2C|MAP 1 -1.4434 M1 1 0 6 -1.4434 2.252218 2.25259 24156 86 873 7 0.801833 0.301847 14|5600|8 -0.318 0 0 975871 Gene Sets membrane 3K1|MAP 767|1045 K11|RIPK2 4 |TAB1 ESRRB|HR 2103|326 GO H1|PMAI GO:00106 positive regulation of cellular carbohydrate 9|5366|91 1 -1.61581 M1 1 0 Biological 19 -1.61581 2.677752 2.561299 24156 62 873 6 0.687285 0.279617 P1|RGN|P -0.42996 0 251 0 0 -1.95287 3.29406 76 metabolic process 04|10891| Processes PARGC1A 85414 |SLC45A3 7057|102 THBS1|RA GO 66|28984| MP2|RGC GO:20003 regulation of endothelial cell apoptotic 1 -1.61581 M1 1 0 Biological 19 -1.61581 2.677752 2.561299 24156 62 873 6 0.687285 0.279617 51129|19 C|ANGPT -0.42996 0 253 0 0 -1.94359 4.427216 51 process Processes 6527|641 L4|ANO6| 700 ECSCR CD34|CD 947|1003| H5|GPC4| 2239|367 ITGA1|IT 2|3673|37 GA2|KCN 62|5156|5 J5|PDGFR 169|5175| A|ENPP3| 5270|638 PECAM1| GO 7|7057|78 SERPINE2 GO:00098 Cellular 1 -1.44163 M1 1 0 20 external side of plasma membrane -1.44163 1.514284 2.013442 24156 402 873 22 2.520046 0.530463 52|9180|2 |CXCL12| -0.31676 0 0 97 Compone 2871|515 THBS1|CX nts 54|56244| CR4|OSM 79679|11 R|NLGN1| 7531|131 ACKR4|BT 450|3894 NL2|VTC 00|72923 N1|TMC1| 0 CD200R1| GFRAL|CC CCN2|SFR 1490|642 GO P1|SYNP GO:00322 positive regulation of actin filament bundle 2|11346|2 1 -1.61581 M1 1 0 Biological 19 -1.61581 2.677752 2.561299 24156 62 873 6 0.687285 0.279617 O|PPM1E| -0.42996 0 256 0 0 -1.92606 4.256939 33 assembly 2843|229 Processes LIMCH1|R 98|28984 GCC CMKLR1| 1240|423 MFAP2|C 7|7852|10 GO XCR4|PPA GO:01201 positive regulation of cold-induced 891|5048 1 -1.61535 M1 1 0 Biological 19 -1.61535 2.28207 2.44991 24156 97 873 8 0.91638 0.322501 RGC1A|G -0.42996 0 93 0 0 -3.70842 5.321174 62 thermogenesis 6|56034|6 Processes 0S2|PDGF 4641|729 C|EBF2|C 230 CR2 GO 2890|290 GRIA1|GR GO:00083 Cellular 2|10369|2 IN1|CAC 1 -1.4385 M1 1 0 20 ionotropic glutamate receptor complex -1.4385 2.712755 2.370926 24156 51 873 5 0.572738 0.255402 -0.31514 0 0 28 Compone 2871|375 NG2|NLG nts 567 N1|VWC2 1266|290 CNN3|ST GO GO:00986 91|29766| XBP6|TM 1 -1.4385 M1 1 0 Molecular 21 cell-cell adhesion mediator activity -1.4385 2.712755 2.370926 24156 51 873 5 0.572738 0.255402 -0.31514 0 0 32 91624|34 OD3|NEX Functions 2035 N|GLDN GRIA1|GR 2890|290 IN1|MAP KEGG 1 -1.4385 hsa05014 M1 1 0 24 Amyotrophic lateral sclerosis (ALS) -1.4385 2.712755 2.370926 24156 51 873 5 0.572738 0.255402 2|5600|71 K11|TNFR -0.31514 0 0 Pathway 32|7133 SF1A|TNF RSF1B BIRC5|FA 332|355|1 S|CDK6|C 021|1385| REB1|E2F KEGG 1870|408 1 -1.43816 hsa05161 M1 1 0 24 Hepatitis B -1.43816 1.921535 2.147682 24156 144 873 10 1.145475 0.360151 2|SMAD4| -0.31514 0 0 Pathway 9|4214|47 MAP3K1| 72|8772|9 NFATC1|F 134 ADD|CCN 2048|370 EPHB2|IT Canonical 1 -1.43748 M18342 M1 1 0 11 ST G ALPHA I PATHWAY -1.43748 3.162297 2.478809 24156 35 873 4 0.45819 0.22857 6|3762|53 PKA|KCNJ -0.31514 0 0 Pathways 08 5|PITX2 FAS|CASP Canonical 355|835|7 1 -1.43748 M197 M1 1 0 11 PID HIV NEF PATHWAY -1.43748 3.162297 2.478809 24156 35 873 4 0.45819 0.22857 2|TNFRSF -0.31514 0 0 Pathways 132|8772 1A|FADD GO GO:00708 negative regulation of glycogen metabolic 5167|231 ENPP1|PA 1 -1.61479 M1 1 0 Biological 19 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 73 0 0 -4.32747 27.6701 74 process 78 SK Processes GO GO:00216 5629|854 PROX1|K 1 -1.61479 M1 1 0 Biological 19 cerebellar granular layer formation -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 92 0 0 -3.73382 12.29782 84 42 NDC1 Processes GO GO:00217 5629|854 PROX1|K 1 -1.61479 M1 1 0 Biological 19 cerebellar granule cell differentiation -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 92 0 0 -3.73382 12.29782 07 42 NDC1 Processes 1021|103 CDK6|CD R-HSA- Reactome 1 -1.43748 M1 1 0 6 Oncogene Induced Senescence -1.43748 3.162297 2.478809 24156 35 873 4 0.45819 0.22857 0|1870|70 KN2B|E2F -0.31514 0 0 2559585 Gene Sets 29 2|TFDP2 GO GO:00512 9493|241 KIF23|KIF 1 -1.61479 M1 1 0 Biological 19 mitotic spindle midzone assembly -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 102 0 0 -3.49473 18.44674 56 37 4A Processes XIAP|FAS| 331|355|2 GAS2|LM 620|4001| NB1|PMA 5366|702 IP1|TFDP R-HSA- Reactome 9|8655|87 1 -1.43311 M1 1 0 6 Programmed Cell Death -1.43311 1.794817 2.101364 24156 185 873 12 1.37457 0.394068 2|DYNLL1 -0.31119 0 0 5357801 Gene Sets 43|8772|6 |TNFSF10| 3967|904 FADD|CLS 27|10050 PN|BMF| 6658 OCLN GO GO:00516 2824|369 GPM6B|IT 1 -1.61479 M1 1 0 Biological 19 serotonin uptake -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 111 0 0 -3.35124 18.44674 10 0 GB3 Processes GO TNFRSF1 GO:19047 positive regulation of apoptotic process 7132|713 1 -1.61479 M1 1 0 Biological 19 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 A|TNFRSF -0.42996 0 113 0 0 -3.34087 13.83505 47 involved in development 3 Processes 1B GPX7|HB 2882|303 A1|PTGS1 GO 9|5742|72 GO:00162 |TXNRD1| 1 -1.42014 M1 1 0 Molecular 21 antioxidant activity -1.42014 2.22633 2.218856 24156 87 873 7 0.801833 0.301847 96|10587| -0.29981 0 0 09 TXNRD2| Functions 137902|1 PXDNL|S 40809 RXN1 BHMT|PR 635|639|1 DM1|CO 312|1789| MT|DNM 2122|261 T3B|MEC 8|8726|25 OM|GART GO GO:00167 transferase activity, transferring one- 840|5409 |EED|MET 1 -1.41872 M1 1 0 Molecular 21 -1.41872 1.699041 2.053564 24156 228 873 14 1.603666 0.425147 -0.29981 0 0 41 carbon groups 3|57604|7 TL7A|SET Functions 9723|154 D4|TRMT 743|2837 9B|SUV39 42|72846 H2|BMT2| 4 FAM98B| METTL24 GO GO:00722 metanephric nephron tubule epithelial cell 3976|104 1 -1.61479 M1 1 0 Biological 19 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 LIF|YAP1 -0.42996 0 118 0 0 -3.28677 7.905744 57 differentiation 13 Processes GO GO:00723 regulation of metanephric nephron tubule 3976|104 1 -1.61479 M1 1 0 Biological 19 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 LIF|YAP1 -0.42996 0 118 0 0 -3.28677 7.905744 07 epithelial cell differentiation 13 Processes GO GO:00380 CD34|FGF 1 -1.61479 M1 1 0 Biological 19 paracrine signaling -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 947|2247 -0.42996 0 119 0 0 -3.27941 18.44674 01 2 Processes GO GO:00147 2047|219 EPHB1|GJ 1 -1.61479 M1 1 0 Biological 19 skeletal muscle satellite cell activation -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 126 0 0 -3.20893 9.223368 19 770 D4 Processes ACTN1|F GO 87|2275|1 HL3|NEBL GO:00017 Cellular 0529|113 1 -1.41649 M1 1 0 20 stress fiber -1.41649 2.406096 2.264849 24156 69 873 6 0.687285 0.279617 |SYNPO|LI -0.29981 0 0 25 Compone 46|22998| MCH1|PD nts 27295 LIM3 ADORA2 GO 135|1393| A|CRHBP| GO:00443 Cellular 4155|707 1 -1.41649 M1 1 0 20 main axon -1.41649 2.406096 2.264849 24156 69 873 6 0.687285 0.279617 MBP|TIA -0.29981 0 0 04 Compone 4|7133|57 M1|TNFR nts 165 SF1B|GJC ACTN1|F GO 87|2275|1 HL3|NEBL GO:00975 Cellular 0529|113 1 -1.41649 M1 1 0 20 contractile actin filament bundle -1.41649 2.406096 2.264849 24156 69 873 6 0.687285 0.279617 |SYNPO|LI -0.29981 0 0 17 Compone 46|22998| MCH1|PD nts 27295 LIM3 4175|715 MCM6|T GO GO:00080 3|8458|54 OP2A|TTF 1 -1.41649 M1 1 0 Molecular 21 DNA-dependent ATPase activity -1.41649 2.406096 2.264849 24156 69 873 6 0.687285 0.279617 -0.29981 0 0 94 821|7907 2|ERCC6L| Functions 5|80119 DSCC1|PI 1021|187 CDK6|E2F KEGG 0|2247|42 2|FGF2|M 1 -1.41649 hsa05218 M1 1 0 24 Melanoma -1.41649 2.406096 2.264849 24156 69 873 6 0.687285 0.279617 -0.29981 0 0 Pathway 33|5156|5 ET|PDGFR 6034 A|PDGFC ACTC1|A CTN2|CA 70|88|815 MK2A|ITG |3672|375 A1|KCNJ2 9|4632|63 |MYL1|SC R-HSA- Reactome 1 -1.41648 M1 1 0 6 Muscle contraction -1.41648 1.737736 2.064114 24156 207 873 13 1.489118 0.40992 28|7135|7 N3A|TNN -0.29981 0 0 397014 Gene Sets 136|7139| I1|TNNI2| 7140|103 TNNT2|T 69|29766 NNT3|CA CNG2|TM OD3 GO GO:00607 2277|522 VEGFD|P 1 -1.61479 M1 1 0 Biological 19 regulation of mast cell chemotaxis -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 137 0 0 -3.04056 10.37629 53 8 GF Processes GO GO:00714 FAS|DNM 1 -1.61479 M1 1 0 Biological 19 cellular response to hyperoxia -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 355|1789 -0.42996 0 141 0 0 -2.97821 18.44674 55 T3B Processes Canonical 1385|560 CREB1|M 1 -1.41425 M199 M1 1 0 11 PID P38 MK2 PATHWAY -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 -0.29981 0 0 Pathways 0|7054 APK11|TH GO GO:00513 chromosome movement towards spindle 1062|978 CENPE|DL 1 -1.61479 M1 1 0 Biological 19 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 155 0 0 -2.83885 13.83505 05 pole 7 GAP5 Processes GO GO:00329 positive regulation of transforming growth 4060|705 LUM|THB 1 -1.61479 M1 1 0 Biological 19 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 163 0 0 -2.77297 7.905744 14 factor beta1 production 7 S1 Processes GO GO:00033 2618|408 GART|SM 1 -1.61479 M1 1 0 Biological 19 brainstem development -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 197 0 0 -2.41795 18.44674 60 9 AD4 Processes GO GO:00322 positive regulation of gonadotropin 3624|408 INHBA|S 1 -1.61479 M1 1 0 Biological 19 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 197 0 0 -2.41795 18.44674 78 secretion 9 MAD4 Processes GO GO:00468 3624|408 INHBA|S 1 -1.61479 M1 1 0 Biological 19 follicle-stimulating hormone secretion -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 197 0 0 -2.41795 18.44674 84 9 MAD4 Processes GO GO:00333 7272|931 TTK|TRIP1 1 -1.61479 M1 1 0 Biological 19 meiotic cell cycle checkpoint -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 217 0 0 -2.20452 9.223368 13 9 3 Processes GO GO:00424 7054|260 TH|MOX 1 -1.61479 M1 1 0 Biological 19 norepinephrine biosynthetic process -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 219 0 0 -2.20452 7.905744 21 02 D1 Processes GO GO:00427 23379|79 1 -1.61479 M1 1 0 Biological 19 snRNA transcription by RNA polymerase III -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 ICE1|ICE2 -0.42996 0 231 0 0 -2.12745 13.83505 96 664 Processes GO GO:00602 regulation of cilium movement involved in 126731|2 CCSAP|G 1 -1.61479 M1 1 0 Biological 19 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 235 0 0 -2.09129 7.905744 95 cell motility 46176 AS2L2 Processes GO GO:00602 regulation of cilium beat frequency 126731|2 CCSAP|G 1 -1.61479 M1 1 0 Biological 19 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 235 0 0 -2.09129 7.905744 96 involved in ciliary motility 46176 AS2L2 Processes GO GO:19020 126731|2 CCSAP|G 1 -1.61479 M1 1 0 Biological 19 regulation of cilium-dependent cell motility -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 235 0 0 -2.09129 7.905744 19 46176 AS2L2 Processes GO GO:20005 positive regulation of microtubule motor 8655|551 DYNLL1| 1 -1.61479 M1 1 0 Biological 19 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 246 0 0 -1.98904 9.223368 76 activity 12 WDR60 Processes GO GO:19042 regulation of chemokine (C-C motif) ligand 4155|106 MBP|POS 1 -1.61479 M1 1 0 Biological 19 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 258 0 0 -1.91611 11.06804 07 2 secretion 31 TN Processes GO 55112|55 WDR60|C GO:00002 Cellular 1 -1.41425 M1 1 0 20 pericentriolar material -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 125|1214 EP192|NE -0.29981 0 0 42 Compone 41 DD1 nts GO 57165|57 GO:00059 Cellular GJC2|GJD 1 -1.41425 M1 1 0 20 connexin complex -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 369|2197 -0.29981 0 0 22 Compone 2|GJD4 70 nts GO 5167|102 ENPP1|PR GO:00018 1 -1.41425 M1 1 0 Molecular 21 pattern binding -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 16|49719 G4|CLEC1 -0.29981 0 0 71 Functions 0 8B GO 5167|102 ENPP1|PR GO:00302 1 -1.41425 M1 1 0 Molecular 21 polysaccharide binding -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 16|49719 G4|CLEC1 -0.29981 0 0 47 Functions 0 8B ACTN2|C R-HSA- Reactome Ras activation upon Ca2+ influx through 88|815|29 1 -1.41425 M1 1 0 6 -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 AMK2A|G -0.29981 0 0 442982 Gene Sets NMDA receptor 02 RIN1 MET|PTP R-HSA- Reactome 4233|579 1 -1.41425 M1 1 0 6 Negative regulation of MET activity -1.41425 3.952872 2.62133 24156 21 873 3 0.343643 0.198061 RJ|SH3GL -0.29981 0 0 6807004 Gene Sets 5|6456 2 GO GO:00092 pyrimidine deoxyribonucleoside 1841|185 DTYMK|D 1 -1.61479 M1 1 0 Biological 19 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 266 0 0 -1.88377 7.905744 11 triphosphate metabolic process 4 UT Processes BARD1|B 580|672|6 RCA1|BR 75|3838|4 CA2|KPN 361|7520| R-HSA- Reactome A2|MRE1 1 -1.40854 M1 1 0 6 DNA Double-Strand Break Repair -1.40854 1.833561 2.086736 24156 166 873 11 1.260023 0.37751 9156|551 -0.29764 0 0 5693532 Gene Sets 1|XRCC5| 83|63967| EXO1|RIF 80010|14 1|CLSPN| 6956 RMI1|EM GO GO:19033 4208|517 MEF2C|PE 1 -1.61479 M1 1 0 Biological 19 positive regulation of fear response -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 271 0 0 -1.81429 7.905744 67 9 NK Processes GO GO:20009 positive regulation of behavioral fear 4208|517 MEF2C|PE 1 -1.61479 M1 1 0 Biological 19 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 271 0 0 -1.81429 7.905744 87 response 9 NK Processes GO GO:19900 inhibition of cysteine-type endopeptidase 331|7944 XIAP|BIRC 1 -1.61479 M1 1 0 Biological 19 -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 273 0 0 -1.80786 9.223368 01 activity involved in apoptotic process 4 7 Processes GO GO:00604 10413|15 YAP1|RD 1 -1.61479 M1 1 0 Biological 19 bud elongation involved in lung branching -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 284 0 0 -1.70748 7.905744 49 7506 H10 Processes GO GO:00486 1134|709 CHRNA1| 1 -1.61479 M1 1 0 Biological 19 skeletal muscle tissue growth -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 292 1 1 -1.61479 7.905744 30 3 TLL2 Processes CRHBP|C GO 1393|139 GO:00170 RHR2|INH 1 -1.4072 M1 1 0 Molecular 21 peptide hormone binding -1.4072 2.660587 2.321186 24156 52 873 5 0.572738 0.255402 5|3624|48 -0.29764 0 0 46 BA|NPR3| Functions 83|10266 RAMP2 GO GO:00324 56155|14 TEX14|E2 1 -1.61479 M1 1 0 Biological 19 negative regulation of cytokinesis -1.61479 7.905744 3.538352 24156 7 873 2 0.229095 0.161809 -0.42996 0 293 1 1 -1.61479 7.905744 66 4455 F7 Processes AGTR2|B 186|580|9 ARD1|CD 83|1894|2 K1|ECT2|S 040|5116| TOM|PCN GO 5174|958 T|PDZK1| GO:00331 1 -1.61475 M1 1 0 Biological 19 regulation of intracellular protein transport -1.61475 1.766177 2.285412 24156 235 873 15 1.718213 0.439813 5|9648|23 KIF20B|G -0.42996 0 224 0 0 -2.14044 2.813909 57 Processes 379|2996 CC2|ICE1| 9|51512|5 MDFIC|G 1715|801 TSE1|RAB 84|84455 23|CEP29 0|EFCAB7 AGTR2|B MP7|BRC 186|655|6 A1|CDO1| 72|1036|1 CPN1|CC 369|1490| N2|DNMT 1789|210 3B|ESRRB| 3|4916|59 NTRK3|RB 31|6095|6 GO BP7|ROR GO:00485 258|6422| 1 -1.60993 M1 1 0 Biological 19 response to steroid hormone -1.60993 1.577053 2.213021 24156 386 873 22 2.520046 0.530463 A|RXRG|S -0.42875 0 150 0 0 -2.88568 1.913358 45 7054|705 Processes FRP1|TH| 7|10266|1 THBS1|RA 0413|108 MP2|YAP 91|56937| 1|PPARG 84687|85 C1A|PME 315|1615 PA1|PPP1 82 R9B|PAQ R8|DNAA CORUM:1 FA core complex (Fanconi anemia core 2187|218 FANCB|F 1 -1.40148 M1 1 0 CORUM 33 -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 624 complex) 8 ANCF GO 894|1164| CCND2|C GO:00457 positive regulation of cyclin-dependent 1 -1.60984 M1 1 0 Biological 19 -1.60984 3.570336 2.772862 24156 31 873 4 0.45819 0.22857 5629|289 KS2|PROX -0.42875 0 37 0 0 -6.01116 5.929308 37 protein serine/threonine kinase activity Processes 84 1|RGCC EPHB2|N GO 2048|491 GO:00990 TRK3|NLG 1 -1.60984 M1 1 0 Biological 19 postsynapse assembly -1.60984 3.570336 2.772862 24156 31 873 4 0.45819 0.22857 6|22871|3 -0.42875 0 63 0 0 -4.50244 10.37629 68 N1|LRRT Processes 47730 M1 GO 655|9104| BMP7|RG GO:00003 1 -1.60984 M1 1 0 Biological 19 response to oxygen radical -1.60984 3.570336 2.772862 24156 31 873 4 0.45819 0.22857 10516|10 N|FBLN5| -0.42875 0 120 0 0 -3.26614 6.385408 05 Processes 587 TXNRD2 VCAN|UG GO 1462|735 GO:00506 chondroitin sulfate proteoglycan DH|CHST 1 -1.60984 M1 1 0 Biological 19 -1.60984 3.570336 2.772862 24156 31 873 4 0.45819 0.22857 8|51363|5 -0.42875 0 228 0 0 -2.12745 13.83505 50 biosynthetic process 15|CSGAL Processes 5790 NACT1 GO 2247|423 FGF2|MET GO:00357 1 -1.60984 M1 1 0 Biological 19 endothelial cell chemotaxis -1.60984 3.570336 2.772862 24156 31 873 4 0.45819 0.22857 3|5587|70 |PRKD1|T -0.42875 0 232 0 0 -2.12027 5.534021 67 Processes 57 HBS1 GO 1816|289 DRD5|GRI GO:00602 1 -1.60984 M1 1 0 Biological 19 long-term synaptic depression -1.60984 3.570336 2.772862 24156 31 873 4 0.45819 0.22857 0|23237|5 A1|ARC|S -0.42875 0 288 0 0 -1.6474 3.570336 92 Processes 7537 ORCS2 SLC25A4| GO 291|1089 GO:00000 PPARGC1 1 -1.60984 M1 1 0 Biological 19 mitochondrial genome maintenance -1.60984 3.570336 2.772862 24156 31 873 4 0.45819 0.22857 1|80119|9 -0.42875 0 294 1 1 -1.60984 3.570336 02 A|PIF1|M Processes 2667 GME1 1907|574 EDN2|PT GO GO:00066 2|7132|14 GS1|TNFR 1 -1.60921 M1 1 0 Biological 19 prostanoid metabolic process -1.60921 3.00762 2.639083 24156 46 873 5 0.572738 0.255402 -0.42875 0 195 0 0 -2.41795 18.44674 92 5482|284 SF1A|PTG Processes 273 R2|ZADH 1907|574 EDN2|PT GO GO:00066 2|7132|14 GS1|TNFR 1 -1.60921 M1 1 0 Biological 19 prostaglandin metabolic process -1.60921 3.00762 2.639083 24156 46 873 5 0.572738 0.255402 -0.42875 0 195 0 0 -2.41795 18.44674 93 5482|284 SF1A|PTG Processes 273 R2|ZADH FGF2|HTR GO 2247|335 GO:19002 2B|NTRK3 1 -1.60921 M1 1 0 Biological 19 regulation of phospholipase C activity -1.60921 3.00762 2.639083 24156 46 873 5 0.572738 0.255402 7|4916|51 -0.42875 0 232 0 0 -2.12027 5.534021 74 |PDGFRA| Processes 56|10125 RASGRP1 HES1|LM GO 3280|854 GO:00485 O4|FADD| 1 -1.60921 M1 1 0 Biological 19 thymus development -1.60921 3.00762 2.639083 24156 46 873 5 0.572738 0.255402 3|8772|91 -0.42875 0 254 0 0 -1.94359 3.640803 38 CCNB2|C Processes 33|80169 TC1 AGTR2|A HR|BMP7| BRCA1|C 186|196|6 RHBP|CY 55|672|13 P1B1|CYP 93|1545|1 24A1|DN 591|1789| MT3B|DR 1816|210 D5|ESRRB 3|3015|32 |H2AZ1|H 69|3624|3 RH1|INHB 673|4090| GO A|ITGA2|S GO:00714 cellular response to organic cyclic 4208|517 1 -1.6055 M1 1 0 Biological 19 -1.6055 1.475061 2.170068 24156 544 873 29 3.321879 0.606525 MAD5|M -0.42528 0 150 0 0 -2.88568 1.913358 07 compound 9|6095|62 Processes EF2C|PEN 58|6422|1 K|RORA|R 0413|108 XRG|SFRP 91|27063| 1|YAP1|P 54464|56 PARGC1A 937|8193 |ANKRD1| 0|84687|8 XRN1|PM 5315|161 EPA1|KIF1 582 8A|PPP1R 9B|PAQR 8|DNAAF ADORA2 A|XIAP|BI 135|331|3 RC5|FAS| 32|355|14 CCN2|PM 90|5366|7 GO AIP1|THB GO:00432 regulation of cysteine-type endopeptidase 057|8743| 1 -1.60415 M1 1 0 Biological 19 -1.60415 1.801774 2.286606 24156 215 873 14 1.603666 0.425147 S1|TNFSF -0.42486 0 116 0 0 -3.2998 2.23146 81 activity involved in apoptotic process 8772|981 Processes 10|FADD| 2|9966|23 DELE1|TN 151|5503 FSF15|GR 1|79444 AMD4|US P47|BIRC AGTR2|C RABP2|FN 186|1382| 1|GOLGA 2335|280 4|NTRK3| 3|4916|63 CXCL12|S GO 87|6456|6 GO:00485 H3GL2|A 1 -1.60037 M1 1 0 Biological 19 developmental cell growth -1.60037 1.758693 2.267946 24156 236 873 15 1.718213 0.439813 790|7074| -0.42159 0 29 0 0 -6.42481 3.074456 88 URKA|TIA Processes 7852|942 M1|CXCR 3|9723|10 4|NTN1|S 631|5443 EMA3E|P 7|151835 OSTN|SE MA5B|CP BRCA2|FA 675|2187| NCB|TTF1 7270|752 |XRCC5|R GO 0|9104|27 GO:00510 negative regulation of DNA metabolic GN|ANKR 1 -1.59514 M1 1 0 Biological 19 -1.59514 1.963685 2.330651 24156 155 873 11 1.260023 0.37751 063|5446 -0.41685 0 85 0 0 -3.87201 3.458763 53 process D1|XRN1| Processes 4|55010|5 PARPBP|R 5183|801 IF1|PIF1|C 19|80169 TC1 ALK|BMP 238|655|2 7|GRIN1|I 902|3706| TPKA|ME GO 4208|707 GO:00507 F2C|TIAM 1 -1.59514 M1 1 0 Biological 19 regulation of dendrite development -1.59514 1.963685 2.330651 24156 155 873 11 1.260023 0.37751 4|11141|2 -0.41685 0 107 0 0 -3.41128 3.074456 73 1|IL1RAPL Processes 2871|232 1|NLGN1| 37|26037| ARC|SIPA 85442 1L1|KND 3280|420 HES1|ME GO 8|6491|96 F2C|STIL| GO:00350 1 -1.59243 M1 1 0 Biological 19 embryonic heart tube development -1.59243 2.421134 2.465353 24156 80 873 7 0.801833 0.301847 45|10413| MICAL2|Y -0.41662 0 216 0 0 -2.20732 5.270496 50 Processes 51098|33 AP1|IFT52 9829 |CCDC39 GO BHMT|D GO:00065 635|2995 1 -1.59183 M1 1 0 Biological 19 amino-acid betaine metabolic process -1.59183 4.611684 2.968155 24156 18 873 3 0.343643 0.198061 MGDH|C -0.41662 0 134 0 0 -3.06206 27.6701 77 8|55349 Processes HDH GO 6387|196 CXCL12|A GO:00900 1 -1.59183 M1 1 0 Biological 19 positive regulation of monocyte chemotaxis -1.59183 4.611684 2.968155 24156 18 873 3 0.343643 0.198061 527|7292 NO6|CCR -0.41662 0 152 0 0 -2.8845 27.6701 26 Processes 30 2 GO BRCA1|D GO:00515 positive regulation of histone H3-K4 672|1789| 1 -1.59183 M1 1 0 Biological 19 -1.59183 4.611684 2.968155 24156 18 873 3 0.343643 0.198061 NMT3B|S -0.41662 0 184 0 0 -2.53893 6.917526 71 methylation 4089 Processes MAD4 GO ALDH1A3 GO:00600 220|1036 1 -1.59183 M1 1 0 Biological 19 reflex -1.59183 4.611684 2.968155 24156 18 873 3 0.343643 0.198061 |CACNG2| -0.41662 0 194 0 0 -2.41795 18.44674 04 9|117531 Processes TMC1 GO 143686|1 SESN3|B GO:19042 1 -1.59183 M1 1 0 Biological 19 negative regulation of TORC1 signaling -1.59183 4.611684 2.968155 24156 18 873 3 0.343643 0.198061 54743|65 MT2|CAS -0.41662 0 222 0 0 -2.17721 4.882959 62 Processes 2968 TOR1 GO 4603|916 MYBL1|T GO:00345 1 -1.59183 M1 1 0 Biological 19 piRNA metabolic process -1.59183 4.611684 2.968155 24156 18 873 3 0.343643 0.198061 46|15076 DRD12|G -0.41662 0 226 0 0 -2.13239 11.06804 87 Processes 3 PAT2 GO ALDH1A2 GO:00721 8854|909 1 -1.59183 M1 1 0 Biological 19 ureter development -1.59183 4.611684 2.968155 24156 18 873 3 0.343643 0.198061 |TBX18|S -0.41662 0 267 0 0 -1.8828 4.611684 89 6|30812 Processes OX8 GO 56155|14 GO:00517 TEX14|E2 1 -1.59183 M1 1 0 Biological 19 negative regulation of cell division -1.59183 4.611684 2.968155 24156 18 873 3 0.343643 0.198061 4455|259 -0.41662 0 293 0 0 -1.61479 7.905744 82 F7|ASPM Processes 266 COMT|CR 1312|138 EB1|CRHB 5|1393|18 P|DRD5|E 16|2048|2 PHB2|GRI 890|2902| A1|GRIN1 GO 3269|420 GO:00076 |HRH1|M 1 -1.58656 M1 1 0 Biological 19 learning or memory -1.58656 1.715975 2.238816 24156 258 873 16 1.832761 0.453972 8|4885|70 -0.41183 0 214 0 0 -2.21248 4.19244 11 EF2C|NPT Processes 54|11346| X2|TH|SY 23237|84 NPO|ARC 687|1394 |PPP1R9B 11|16431 |PTCHD1| 2 LRRN4 CDK6|CR 1021|138 EB1|FBN1 5|2200|36 |INHBA|L 24|3958|3 GALS3|LIF 976|4208| |MEF2C| GO GO:00456 5600|642 MAPK11| 1 -1.58656 M1 1 0 Biological 19 regulation of myeloid cell differentiation -1.58656 1.715975 2.238816 24156 258 873 16 1.832761 0.453972 -0.41183 0 296 1 1 -1.58656 2.075258 37 2|7057|81 SFRP1|TH Processes 11|8357|8 BS1|GPR6 772|5489 8|H3C10| 2|54997|6 FADD|NC 53604 APG2|TES C|H3C13 GO GO:00008 Cellular 4998|499 ORC1|OR 1 -1.40148 M1 1 0 20 origin recognition complex -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 08 Compone 9 C2 nts GO GO:00056 Cellular nuclear origin of replication recognition 4998|499 ORC1|OR 1 -1.40148 M1 1 0 20 -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 64 Compone complex 9 C2 nts GO GO:00312 Cellular FAS|FAD 1 -1.40148 M1 1 0 20 death-inducing signaling complex -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 355|8772 -0.29764 0 0 64 Compone D nts GO GO:00431 Cellular 1393|713 CRHBP|T 1 -1.40148 M1 1 0 20 varicosity -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 96 Compone 3 NFRSF1B nts GO GO:00976 Cellular 10266|16 RAMP2|G 1 -1.40148 M1 1 0 20 G protein-coupled receptor complex -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 48 Compone 5829 PR156 nts GO GO:00988 Cellular extrinsic component of postsynaptic 3838|707 KPNA2|TI 1 -1.40148 M1 1 0 20 -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 90 Compone membrane 4 AM1 nts GO TNFRSF1 GO:00050 tumor necrosis factor-activated receptor 7132|713 1 -1.40148 M1 1 0 Molecular 21 -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 A|TNFRSF -0.29764 0 0 31 activity 3 Functions 1B GO GO:00080 2047|204 EPHB1|EP 1 -1.40148 M1 1 0 Molecular 21 axon guidance receptor activity -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 46 8 HB2 Functions GO GO:00089 9388|171 LIPG|ABH 1 -1.40148 M1 1 0 Molecular 21 phospholipase A1 activity -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 70 586 D3 Functions GO GO:00355 5167|516 ENPP1|E 1 -1.40148 M1 1 0 Molecular 21 NADH pyrophosphatase activity -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 29 9 NPP3 Functions GO GO:00431 vascular endothelial growth factor receptor 1003|369 CDH5|ITG 1 -1.40148 M1 1 0 Molecular 21 -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 84 2 binding 0 B3 Functions R-HSA- Reactome BH3-only proteins associate with and 5366|904 PMAIP1|B 1 -1.40148 M1 1 0 6 -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 111453 Gene Sets inactivate anti-apoptotic BCL-2 members 27 MF R-HSA- Reactome 3672|367 ITGA1|IT 1 -1.40148 M1 1 0 6 CHL1 interactions -1.40148 6.148912 2.99155 24156 9 873 2 0.229095 0.161809 -0.29764 0 0 447041 Gene Sets 3 GA2 983|2247| CDK1|FGF GO GO:00466 4208|562 2|MEF2C| 1 -1.58534 M1 1 0 Biological 19 positive regulation of organ growth -1.58534 2.635248 2.516516 24156 63 873 6 0.687285 0.279617 -0.41132 0 117 0 0 -3.28848 6.510612 22 9|10413|2 PROX1|Y Processes 3414 AP1|ZFP BMP7|DA 655|1600| B1|EPHB1 2047|204 |EPHB2|S 8|4089|49 MAD4|NR 02|6387|7 TN|CXCL1 GO 852|9423| 2|CXCR4| GO:00074 1 -1.5768 M1 1 0 Biological 19 axon guidance -1.5768 1.679971 2.21605 24156 280 873 17 1.947308 0.467671 9723|237 NTN1|SE -0.40325 0 29 0 0 -6.42481 3.074456 11 Processes 68|55816| MA3E|FLR 91624|91 T2|DOK5| 653|1335 NEXN|BO 84|28421 C|EGFLA 7|284656 M|LAMA1 |EPHA10 AGTR2|C GO 186|1393| GO:00609 RHBP|INH 1 -1.57303 M1 1 0 Biological 19 endocrine hormone secretion -1.57303 2.943628 2.582639 24156 47 873 5 0.572738 0.255402 3624|408 -0.40114 0 197 0 0 -2.41795 18.44674 86 BA|SMAD Processes 9|114899 4|C1QTN GO 3015|872 H2AZ1|EE GO:00057 Cellular 1 -1.39849 M1 1 0 20 nuclear heterochromatin -1.39849 3.074456 2.411893 24156 36 873 4 0.45819 0.22857 6|29128|1 D|UHRF1| -0.29545 0 0 20 Compone 46956 EME1 nts KCNA4|K 3739|375 CNJ2|KC GO 9|3762|93 GO:00052 NJ5|KCNB 1 -1.3973 M1 1 0 Molecular 21 voltage-gated potassium channel activity -1.3973 2.201031 2.18558 24156 88 873 7 0.801833 0.301847 12|27133| -0.29447 0 0 49 2|KCNH5| Functions 81033|12 KCNH6|L 6755 RRC38 1385|290 CREB1|GR GO GO:00085 2|3269|11 IN1|HRH1 1 -1.57303 M1 1 0 Biological 19 visual learning -1.57303 2.943628 2.582639 24156 47 873 5 0.572738 0.255402 -0.40114 0 214 0 0 -2.21248 4.19244 42 346|1643 |SYNPO|L Processes 12 RRN4 3914|108 LAMB3|P GO GO:00508 91|30001| PARGC1A 1 -1.57303 M1 1 0 Biological 19 brown fat cell differentiation -1.57303 2.943628 2.582639 24156 47 873 5 0.572738 0.255402 -0.40114 0 243 0 0 -2.01194 2.943628 73 64641|25 |ERO1A|E Processes 2995 BF2|FNDC 2187|550 FANCB|P GO GO:00105 regulation of double-strand break repair 10|55137| ARPBP|FI 1 -1.57303 M1 1 0 Biological 19 -1.57303 2.943628 2.582639 24156 47 873 5 0.572738 0.255402 -0.40114 0 262 0 0 -1.9094 4.368964 69 via homologous recombination 55183|40 GN|RIF1|F Processes 1720 IGNL2 983|1385| CDK1|CR Canonical 4312|477 EB1|MMP 1 -1.39049 M167 M1 1 0 11 PID AP1 PATHWAY -1.39049 2.371723 2.225483 24156 70 873 6 0.687285 0.279617 -0.28925 0 0 Pathways 2|5179|70 1|NFATC1 54 |PENK|TH AGTR2|F 186|2247| GF2|MEF2 GO 4208|691 GO:00105 negative regulation of endothelial cell C|TBXA2R 1 -1.56863 M1 1 0 Biological 19 -1.56863 2.235968 2.386136 24156 99 873 8 0.91638 0.322501 5|7057|28 -0.39767 0 15 0 0 -9.08083 2.73285 96 migration |THBS1|R Processes 984|5456 GCC|DLL4 7|79812 |MMRN2 1894|949 ECT2|KIF2 3|9585|24 3|KIF20B| GO GO:00616 137|2658 KIF4A|CK 1 -1.56863 M1 1 0 Biological 19 cytoskeleton-dependent cytokinesis -1.56863 2.235968 2.386136 24156 99 873 8 0.91638 0.322501 -0.39767 0 102 0 0 -3.49473 18.44674 40 6|51203|5 AP2|NUS Processes 4443|551 AP1|ANL 65 N|CEP55 4361|475 MRE11|N GO 1|5073|75 EK2|PAR GO:00322 1 -1.56641 M1 1 0 Biological 19 regulation of telomere maintenance -1.56641 2.391243 2.428587 24156 81 873 7 0.801833 0.301847 20|54464| N|XRCC5| -0.39616 0 85 0 0 -3.87201 3.458763 04 Processes 80119|80 XRN1|PIF 169 1|CTC1 GO 1591|517 CYP24A1| GO:00712 1 -1.56408 M1 1 0 Biological 19 cellular response to vitamin -1.56408 3.458763 2.694996 24156 32 873 4 0.45819 0.22857 9|6422|10 PENK|SFR -0.39594 0 87 0 0 -3.8385 5.234884 95 Processes 631 P1|POST BIRC5|BR 332|672|1 CA1|DNM 789|3090| T3B|HIC1| 6095|679 RORA|AU R-HSA- Reactome 0|7022|71 RKA|TFAP 1 -1.38822 M1 1 0 6 SUMOylation -1.38822 1.766177 2.042129 24156 188 873 12 1.37457 0.394068 -0.28719 0 0 2990846 Gene Sets 53|10891| 2C|TOP2 25950|54 A|PPARG 780|5570 C1A|RWD 6 D3|NSMC E4A|NDC E2F2|MC 1870|417 M6|ORC1 5|4998|49 |ORC2|PR R-HSA- Reactome 99|5558|8 1 -1.38671 M1 1 0 6 DNA Replication -1.38671 1.960873 2.102284 24156 127 873 9 1.030928 0.341867 IM2|CDC -0.28619 0 0 69306 Gene Sets 317|8318| 7|CDC45| 9134|553 CCNE2|M 88 CM10 PDGFRA| GO 5156|527 GO:00105 SERPINE2 1 -1.56408 M1 1 0 Biological 19 regulation of platelet activation -1.56408 3.458763 2.694996 24156 32 873 4 0.45819 0.22857 0|7056|17 -0.39594 0 108 0 0 -3.3802 5.825285 43 |THBD|AD Processes 0692 AMTS18 NFATC1|T GO 4772|713 GO:00031 NFRSF1A| 1 -1.56408 M1 1 0 Biological 19 aortic valve development -1.56408 3.458763 2.694996 24156 32 873 4 0.45819 0.22857 2|7133|54 -0.39594 0 113 0 0 -3.34087 13.83505 76 TNFRSF1 Processes 567 B|DLL4 GO 135|1393| ADORA2 GO:00019 1 -1.56408 M1 1 0 Biological 19 synaptic transmission, dopaminergic -1.56408 3.458763 2.694996 24156 32 873 4 0.45819 0.22857 1816|705 A|CRHBP| -0.39594 0 123 0 0 -3.23644 5.764605 63 Processes 4 DRD5|TH CRABP2|R GO 1382|625 GO:00483 XRG|ALD 1 -1.56408 M1 1 0 Biological 19 retinoic acid receptor signaling pathway -1.56408 3.458763 2.694996 24156 32 873 4 0.45819 0.22857 8|8854|92 -0.39594 0 131 0 0 -3.08989 10.37629 84 H1A2|DH Processes 49 RS3 GO 2324|335 FLT4|HTR GO:00705 1 -1.56408 M1 1 0 Biological 19 protein kinase C signaling -1.56408 3.458763 2.694996 24156 32 873 4 0.45819 0.22857 7|27063|8 2B|ANKR -0.39594 0 196 0 0 -2.41795 18.44674 28 Processes 3483 D1|PLVAP UGDH|HS GO 7358|965 GO:00302 heparan sulfate proteoglycan metabolic 2ST1|SUL 1 -1.56408 M1 1 0 Biological 19 -1.56408 3.458763 2.694996 24156 32 873 4 0.45819 0.22857 3|23213|5 -0.39594 0 228 0 0 -2.12745 13.83505 01 process F1|CSGAL Processes 5790 NACT1 GO 2890|290 GRIA1|GR GO:00988 Cellular 2|10369|2 IN1|CAC 1 -1.37675 M1 1 0 20 neurotransmitter receptor complex -1.37675 2.610387 2.272604 24156 53 873 5 0.572738 0.255402 -0.27751 0 0 78 Compone 2871|375 NG2|NLG nts 567 N1|VWC2 XIAP|PM 331|5366| R-HSA- Reactome AIP1|TFD 1 -1.37675 M1 1 0 6 Intrinsic Pathway for Apoptosis -1.37675 2.610387 2.272604 24156 53 873 5 0.572738 0.255402 7029|865 -0.27751 0 0 109606 Gene Sets P2|DYNLL 5|90427 1|BMF FAS|CREB 355|1385| 1|LIF|MAP 3976|560 KEGG K11|TNFR 1 -1.37594 hsa04668 M1 1 0 24 TNF signaling pathway -1.37594 2.049637 2.116912 24156 108 873 8 0.91638 0.322501 0|7132|71 -0.2769 0 0 Pathway SF1A|TNF 33|8772|1 RSF1B|FA 0454 DD|TAB1 FAS|STO M|EPHB1| 355|2040| GPM6B|IT 2047|282 GA1|PDZ 4|3672|51 K1|PECA 74|5175|5 M1|PODX GO 420|7132| L|TNFRSF GO:00985 Cellular 7133|722 1 -1.37534 M1 1 0 20 membrane region -1.37534 1.541736 1.950881 24156 341 873 19 2.176403 0.493838 1A|TNFRS -0.2765 0 0 89 Compone 3|8772|23 F1B|TRPC nts 213|2323 4|FADD|S 7|23433|5 ULF1|ARC 5824|647 |RHOQ|P 50|81930| AG1|SMU 83483 RF2|KIF18 A|PLVAP GO 675|6422| BRCA2|SF GO:00101 1 -1.56408 M1 1 0 Biological 19 response to X-ray -1.56408 3.458763 2.694996 24156 32 873 4 0.45819 0.22857 7056|752 RP1|THB -0.39594 0 274 0 0 -1.7864 3.458763 65 Processes 0 D|XRCC5 CCND2|C 894|899|9 CNF|CCN 01|1030|1 G2|CDKN 164|9133| 2B|CKS2| GO GO:00192 9134|104 CCNB2|C 1 -1.37457 M1 1 0 Molecular 21 kinase regulator activity -1.37457 1.712911 2.009184 24156 210 873 13 1.489118 0.40992 -0.27612 0 0 07 54|28984| CNE2|TA Functions 54757|54 B1|RGCC| 997|8541 FAM20A| 7|285016 TESC|CC NB3|ALK EPHB2|G 2048|223 PC4|LGAL 9|3958|10 S3|CACN GO 369|2343 GO:19043 regulation of protein localization to cell G2|RHOQ 1 -1.56206 M1 1 0 Biological 19 -1.56206 2.110432 2.341396 24156 118 873 9 1.030928 0.341867 3|84455|8 -0.39414 0 270 0 0 -1.84895 2.110432 75 periphery |EFCAB7| Processes 4687|914 PPP1R9B| 61|13157 PKDCC|LR 8 RC15 ACTN2|C 88|794|14 ALB2|CC 90|2995|7 N2|GYPC| 223|7456| TRPC4|WI 9833|232 PF1|MELK GO 37|23433| |ARC|RH GO:00059 Cellular 26064|29 OQ|RAI14 1 -1.37206 M1 1 0 20 cell cortex -1.37206 1.561322 1.954218 24156 319 873 18 2.061856 0.480948 -0.27402 0 0 38 Compone 091|5444 |STXBP6| nts 3|57381|5 ANLN|RH 7619|838 OJ|SHRO 72|84612| OM3|HM 84687|38 CN1|PAR 7755 D6B|PPP1 R9B|INSC CALB2|C DH5|CMK 794|1003| LR1|DRD5 1240|181 |EDN2|ED 6|1907|19 N3|FGF2| 08|2247|2 GPR17|LP 840|2846| AR4|GRIA 2890|290 1|GRIN1| 2|3357|51 HTR2B|P 56|6387|6 GO DGFRA|C GO:00725 869|6915| 1 -1.56072 M1 1 0 Biological 19 divalent inorganic cation homeostasis -1.56072 1.472933 2.123499 24156 526 873 28 3.207331 0.596329 XCL12|TA -0.39304 0 94 0 0 -3.67332 2.548562 07 7223|785 Processes CR1|TBXA 2|9104|10 2R|TRPC4 590|1134 |CXCR4|R 6|22821|3 GN|SCGN 0001|515 |SYNPO|R 54|54757| ASA3|ER 55013|64 O1A|ACK 072|7292 R4|FAM2 30 0A|MCUB |CDH23|C ADORA2 136|983|1 B|CDK1|C 312|2103| OMT|ESR GO 3269|536 RB|HRH1| GO:00620 positive regulation of small molecule 1 -1.55947 M1 1 0 Biological 19 -1.55947 1.93867 2.284847 24156 157 873 11 1.260023 0.37751 6|5563|91 PMAIP1|P -0.39202 0 251 0 0 -1.95287 3.29406 13 metabolic process Processes 04|10891| RKAA2|R 85414|15 GN|PPAR 7506 GC1A|SLC 45A3|RD BMP7|CD K1|CYP1B 655|983|1 1|ECT2|G 545|1894| PX7|HBA1 2882|303 |MET|PDG 9|4233|51 FRA|PENK 56|5179|5 |PRKAA2| 563|5587| PRKD1|PT 5742|729 GO GS1|TXN GO:00069 6|9104|98 1 -1.55842 M1 1 0 Biological 19 response to oxidative stress -1.55842 1.510377 2.1353 24156 458 873 25 2.863688 0.564477 RD1|RGN| -0.39121 0 120 0 0 -3.26614 6.385408 79 33|10276| Processes MELK|NE 10516|10 T1|FBLN5| 587|1089 TXNRD2| 1|30001|7 PPARGC1 9912|137 A|ERO1A| 902|1391 PYROXD1 89|14080 |PXDNL|D 9|143686 GKK|SRX N1|SESN3 6387|877 CXCL12|F GO 2|9547|58 ADD|CXC GO:20004 1 -1.55557 M1 1 0 Biological 19 regulation of lymphocyte migration -1.55557 2.594072 2.472593 24156 64 873 6 0.687285 0.279617 494|1314 L14|JAM2 -0.38906 0 152 0 0 -2.8845 27.6701 01 Processes 50|72923 |CD200R1 0 |CCR2 ECT2|HTR 2B|NTRK3 1894|335 |SFRP1|TI 7|4916|64 AM1|ASA 22|7074|8 P2|RGN|U 853|9104| SP6NL|GI 9712|981 T2|ARHG 5|9824|99 AP11A|A 38|10125| RHGAP25 10276|10 |RASGRP1 GO GO:00430 788|2282 |NET1|IQ 1 -1.55505 M1 1 0 Biological 19 regulation of GTPase activity -1.55505 1.495681 2.126284 24156 481 873 26 2.978236 0.575317 -0.38877 0 130 0 0 -3.11246 1.704318 87 1|23216|2 GAP2|RA Processes 5780|260 SA3|TBC1 37|55635| D1|RASG 55785|55 RP3|SIPA 789|5756 1L1|DEPD 8|85397|1 C1|FGD6| 52273|20 DEPDC1B 2151|255 |SIPA1L2| 520 RGS8|FG D5|RANB P3L|ELM MRE11|P GO 4361|555 RIM2|CD GO:00056 Cellular 8|8318|29 1 -1.36504 M1 1 0 20 replication fork -1.36504 2.338319 2.186787 24156 71 873 6 0.687285 0.279617 C45|UHR -0.2691 0 0 57 Compone 128|5538 F1|MCM1 nts 8|80119 0|PIF1 MECOM| 2122|593 RBBP7|H3 R-HSA- Reactome 1|8357|87 1 -1.36504 M1 1 0 6 PKMTs methylate histone lysines -1.36504 2.338319 2.186787 24156 71 873 6 0.687285 0.279617 C10|EED| -0.2691 0 0 3214841 Gene Sets 26|79723| SUV39H2| 653604 H3C13 AHR|XIAP 196|331|6 |BRCA1|C 72|1382|1 RABP2|CY 591|2103| P24A1|ES 6095|625 RRB|ROR GO 8|6422|87 A|RXRG|S GO:00305 1 -1.55114 M1 1 0 Biological 19 intracellular receptor signaling pathway -1.55114 1.668056 2.185073 24156 282 873 17 1.947308 0.467671 67|8854|9 FRP1|RIPK -0.38509 0 150 0 0 -2.88568 1.913358 22 Processes 249|1041 2|ALDH1 3|10454|1 A2|DHRS 0891|569 3|YAP1|T 37|16158 AB1|PPAR 2 GC1A|PM EPA1|DN AGTR2|A 186|196|1 HR|DNM 789|4916| T3B|NTRK 5563|642 3|PRKAA2 GO GO:19016 2|6915|70 |SFRP1|TB 1 -1.54963 M1 1 0 Biological 19 response to ketone -1.54963 1.816724 2.234466 24156 198 873 13 1.489118 0.40992 -0.38451 0 150 0 0 -2.88568 1.913358 54 54|7057|1 XA2R|TH| Processes 0266|104 THBS1|RA 13|54464| MP2|YAP 84687 1|XRN1|P PP1R9B BRCA1|D 672|1789| NMT3B|LI 3976|408 F|SMAD4| 9|4288|50 MKI67|PA GO GO:19022 81|5587|8 X7|PRKD1 1 -1.54963 M1 1 0 Biological 19 regulation of chromatin organization -1.54963 1.816724 2.234466 24156 198 873 13 1.489118 0.40992 -0.38451 0 184 0 0 -2.53893 6.917526 75 318|8726| |CDC45|E Processes 10891|55 ED|PPAR 183|5519 GC1A|RIF 6|93649 1|RESF1| MYOCD BMP7|CD KN2B|CRE 655|1030| B1|CYP24 1385|159 A1|DNMT 1|1789|29 3B|GRIN1 GO 02|3673|5 GO:00075 |ITGA2|PE 1 -1.54479 M1 1 0 Biological 19 response to nutrient -1.54479 1.768865 2.21324 24156 219 873 14 1.603666 0.425147 179|6422| -0.38013 0 87 0 0 -3.8385 5.234884 84 NK|SFRP1 Processes 6915|885 |TBXA2R| 4|9388|10 ALDH1A2 631|6529 |LIPG|POS 68 TN|CAST OR1 ACTN2|A GTR2|AH 88|186|19 R|BRCA1| 6|672|815 CAMK2A| |1385|139 CREB1|CR 3|1395|15 HBP|CRH 83|1816|2 R2|CYP11 200|2902| A1|DRD5| 3269|420 FBN1|GRI 8|5156|51 N1|HRH1| GO 67|5179|5 MEF2C|P GO:00714 cellular response to organonitrogen 1 -1.54424 M1 1 0 Biological 19 -1.54424 1.436806 2.092611 24156 597 873 31 3.550974 0.626348 471|6422| DGFRA|E -0.37981 0 150 0 0 -2.88568 1.913358 17 compound Processes 6935|705 NPP1|PE 4|8767|10 NK|PPAT| 891|2343 SFRP1|ZE 3|54464|5 B1|TH|RIP 5023|560 K2|PPAR 34|84687| GC1A|RH 133060|1 OQ|XRN1 43686|65 |PHIP|PD 2968 GFC|PPP1 R9B|OTO P1|SESN3 CDK1|CO 983|1312| MT|EPHB 2047|224 1|FGF2|IT 7|3673|42 GA2|MEF GO 08|4883|4 2C|NPR3| GO:00330 1 -1.54399 M1 1 0 Biological 19 muscle cell proliferation -1.54399 1.729381 2.198909 24156 240 873 15 1.718213 0.439813 969|5600| OGN|MA -0.3798 0 117 0 0 -3.28848 6.510612 02 Processes 7057|752 PK11|THB 0|10413|1 S1|XRCC5 0891|234 |YAP1|PP 14|93649 ARGC1A| ZFPM2|M 1312|138 COMT|CR 5|2890|29 EB1|GRIA GO GO:00076 02|3269|7 1|GRIN1| 1 -1.54147 M1 1 0 Biological 19 memory -1.54147 2.092697 2.313792 24156 119 873 9 1.030928 0.341867 -0.37783 0 214 0 0 -2.21248 4.19244 13 054|2323 HRH1|TH| Processes 7|139411| ARC|PTC 164312 HD1|LRR 2247|691 FGF2|TBX GO 5|7057|54 A2R|THBS GO:00900 regulation of cell migration involved in 1 -1.54088 M1 1 0 Biological 19 -1.54088 2.362082 2.392364 24156 82 873 7 0.801833 0.301847 567|5738 1|DLL4|R -0.37783 0 15 0 0 -9.08083 2.73285 49 sprouting angiogenesis Processes 1|57608|7 HOJ|JCAD 9812 |MMRN2 4361|475 MRE11|N GO 1|5073|75 EK2|PAR GO:00108 telomere maintenance via telomere 1 -1.54088 M1 1 0 Biological 19 -1.54088 2.362082 2.392364 24156 82 873 7 0.801833 0.301847 20|54464| N|XRCC5| -0.37783 0 85 0 0 -3.87201 3.458763 33 lengthening Processes 80119|80 XRN1|PIF 169 1|CTC1 NTRK3|TB 4916|691 XA2R|TH GO 5|7056|70 GO:19030 positive regulation of response to BD|THBS1 1 -1.54088 M1 1 0 Biological 19 -1.54088 2.362082 2.392364 24156 82 873 7 0.801833 0.301847 57|7852|1 -0.37783 0 108 0 0 -3.3802 5.825285 36 wounding |CXCR4|A Processes 96527|10 NO6|OCL 0506658 N 983|2047| CDK1|EP GO 2247|420 HB1|FGF2 GO:00148 1 -1.54088 M1 1 0 Biological 19 striated muscle cell proliferation -1.54088 2.362082 2.392364 24156 82 873 7 0.801833 0.301847 8|5600|10 |MEF2C| -0.37783 0 117 0 0 -3.28848 6.510612 55 Processes 413|2341 MAPK11| 4 YAP1|ZFP 4361|913 MRE11|C GO GO:00071 4|9319|55 CNE2|TRI 1 -1.53792 M1 1 0 Biological 19 synapsis -1.53792 2.882302 2.527671 24156 48 873 5 0.572738 0.255402 -0.3758 0 9 0 0 -10.3048 5.16914 29 706|8469 P13|NDC Processes 0 1|SPATA2 1294|574 COL7A1| GO GO:00020 4|23213|2 PTHLH|S 1 -1.53792 M1 1 0 Biological 19 chondrocyte development -1.53792 2.882302 2.527671 24156 48 873 5 0.572738 0.255402 -0.3758 0 53 0 0 -4.98746 13.83505 63 5886|359 ULF1|POC Processes 845 1A|RFLNB GO 11004|24 KIF2C|GA GO:00353 Cellular 1 -1.36205 M1 1 0 20 microtubule plus-end -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 6176|344 S2L2|NCK -0.2691 0 0 71 Compone 148 AP5 nts F8|SERPI R-HSA- Reactome 2157|527 1 -1.36205 M1 1 0 6 Common Pathway of Fibrin Clot Formation -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 NE2|THB -0.2691 0 0 140875 Gene Sets 0|7056 D DUSP7|M R-HSA- Reactome 1849|420 1 -1.36205 M1 1 0 6 ERK/MAPK targets -1.36205 3.773196 2.519814 24156 22 873 3 0.343643 0.198061 EF2C|MA -0.2691 0 0 198753 Gene Sets 8|5600 PK11 CDK1|FGF GO 983|2247| GO:00550 positive regulation of cardiac muscle tissue 2|MEF2C| 1 -1.53792 M1 1 0 Biological 19 -1.53792 2.882302 2.527671 24156 48 873 5 0.572738 0.255402 4208|104 -0.3758 0 117 0 0 -3.28848 6.510612 23 growth YAP1|ZFP Processes 13|23414 M2 CDK1|NT 983|4916| RK3|OMG 4974|508 |PAX7|PG 1|5228|54 GO F|PPAT|C GO:00310 71|6387|6 1 -1.53427 M1 1 0 Biological 19 regeneration -1.53427 1.807595 2.215108 24156 199 873 13 1.489118 0.40992 XCL12|AU -0.3726 0 298 1 1 -1.53427 1.807595 99 790|9104| Processes RKA|RGN| 10413|10 YAP1|PO 631|5696 STN|RGM 3|219770 A|GJD4 PRDM1|B 639|675|3 RCA2|INH 624|4090| BA|SMAD 4603|642 5|MYBL1| 2|6790|71 SFRP1|AU 53|7272|9 RKA|TOP GO 319|2339 2A|TTK|T GO:00224 cellular process involved in reproduction in 1 -1.53058 M1 1 0 Biological 19 -1.53058 1.585679 2.134083 24156 349 873 20 2.290951 0.50637 7|56155|5 RIP13|NC -0.37075 0 114 0 0 -3.31277 5.355504 12 multicellular organism Processes 7082|584 APH|TEX1 94|81930| 4|KNL1|JA 84930|85 M2|KIF18 315|9164 A|MASTL| 6|135138| PAQR8|T 259266 DRD12|P ACRG|AS ALDH1A3 |CHAT|C 220|1103| OMT|CRA 1312|138 BP1|CRAB 1|1382|13 P2|CRHB GO 93|1545|1 P|CYP1B1 GO:00424 1 -1.53019 M1 1 0 Biological 19 hormone metabolic process -1.53019 1.722206 2.181852 24156 241 873 15 1.718213 0.439813 583|5125| |CYP11A1 -0.37075 0 131 0 0 -3.08989 10.37629 45 Processes 5156|885 |PCSK5|P 4|9249|95 DGFRA|A 63|10891| LDH1A2| 157506 DHRS3|H 6PD|PPA RGC1A|R GO CREB1|H2 1385|301 GO:00007 Cellular AZ1|PPAR 1 -1.36094 M1 1 0 20 euchromatin -1.36094 2.991362 2.347268 24156 37 873 4 0.45819 0.22857 5|10891|2 -0.2691 0 0 91 Compone GC1A|UH 9128 nts RF1 835|5600| CASP2|M R-HSA- Reactome 1 -1.36094 M1 1 0 6 NOD1/2 Signaling Pathway -1.36094 2.991362 2.347268 24156 37 873 4 0.45819 0.22857 8767|104 APK11|RI -0.2691 0 0 168638 Gene Sets 54 PK2|TAB1 GPX7|TX 2882|729 R-HSA- Reactome NRD1|TX 1 -1.36094 M1 1 0 6 Detoxification of Reactive Oxygen Species -1.36094 2.991362 2.347268 24156 37 873 4 0.45819 0.22857 6|10587|3 -0.2691 0 0 3299685 Gene Sets NRD2|ER 0001 O1A GO GO:00720 3976|107 LIF|SIX2|S 1 -1.52874 M1 1 0 Biological 19 renal vesicle morphogenesis -1.52874 4.368964 2.844609 24156 19 873 3 0.343643 0.198061 -0.37075 0 118 0 0 -3.28677 7.905744 77 36|30812 OX8 Processes ACTN2|C AMK2A|C 88|815|98 DK1|DUS 3|1849|22 P7|FGF2|F 47|2335|2 N1|GRIN1 902|3690| R-HSA- Reactome |ITGB3|M 1 -1.36084 M1 1 0 6 MAPK1/MAPK3 signaling -1.36084 1.634061 1.96708 24156 254 873 15 1.718213 0.439813 4233|490 -0.2691 0 0 5684996 Gene Sets ET|NRTN| 2|5156|10 PDGFRA| 125|2282 RASGRP1| 1|25780|5 RASA3|R 4756 ASGRP3|I L17RD GO GO:00720 655|4089| BMP7|SM 1 -1.52874 M1 1 0 Biological 19 kidney mesenchyme development -1.52874 4.368964 2.844609 24156 19 873 3 0.343643 0.198061 -0.37075 0 153 0 0 -2.8845 27.6701 74 10736 AD4|SIX2 Processes GO GO:00363 2324|562 FLT4|PRO 1 -1.52874 M1 1 0 Biological 19 lymph vessel morphogenesis -1.52874 4.368964 2.844609 24156 19 873 3 0.343643 0.198061 -0.37075 0 196 0 0 -2.41795 18.44674 03 9|147372 X1|CCBE1 Processes GO HES1|SM GO:00613 cell proliferation involved in heart 3280|408 1 -1.52874 M1 1 0 Biological 19 -1.52874 4.368964 2.844609 24156 19 873 3 0.343643 0.198061 AD4|PITX -0.37075 0 198 0 0 -2.41795 18.44674 23 morphogenesis 9|5308 Processes 2 GO FANCB|P GO:20000 negative regulation of double-strand break 2187|550 1 -1.52874 M1 1 0 Biological 19 -1.52874 4.368964 2.844609 24156 19 873 3 0.343643 0.198061 ARPBP|RI -0.37075 0 262 0 0 -1.9094 4.368964 42 repair via homologous recombination 10|55183 Processes F1 AGTR2|C 186|1003| DH5|ITGA 3672|395 1|LGALS3| GO 8|9104|57 GO:00353 RGN|PPP 1 -1.52841 M1 1 0 Biological 19 regulation of protein dephosphorylation -1.52841 1.990655 2.268097 24156 139 873 10 1.145475 0.360151 718|8468 -0.37064 0 199 0 0 -2.40034 2.76701 04 4R4|PPP1 Processes 7|84930|1 R9B|MAS 57313|39 TL|CDCA2 2617 |ELFN1 COL4A5| 1287|128 COL4A6| 8|1289|12 COL5A1| KEGG 1 -1.35284 hsa04974 M1 1 0 24 Protein digestion and absorption -1.35284 2.152119 2.120351 24156 90 873 7 0.801833 0.301847 94|1299|1 COL7A1| -0.26228 0 0 Pathway 306|1318 COL9A3| 73 COL15A1| COL6A6 BRCA2|M 675|4175| GO CM6|PRI GO:00447 5558|831 1 -1.52649 M1 1 0 Biological 19 cell cycle DNA replication -1.52649 2.554163 2.429501 24156 65 873 6 0.687285 0.279617 M2|CDC7 -0.36963 0 20 0 0 -7.69554 7.546392 86 7|8318|14 Processes |CDC45|E 4455 2F7 ACTN1|C 87|1131|2 HRM3|FG 247|2335| F2|FN1|IT 3672|367 GA1|ITGA KEGG 3|3690|36 2|ITGB3|I 1 -1.34728 hsa04810 M1 1 0 24 Regulation of actin cytoskeleton -1.34728 1.696752 1.973053 24156 212 873 13 1.489118 0.40992 -0.25792 0 0 Pathway 91|5156|7 TGB4|PD 074|1078 GFRA|TIA 8|22800|5 M1|IQGA 6034 P2|RRAS2 |PDGFC FAS|ITGB 355|3691| Canonical 4|PMAIP1 1 -1.34712 M256 M1 1 0 11 PID TAP63 PATHWAY -1.34712 2.562047 2.225131 24156 54 873 5 0.572738 0.255402 5366|702 -0.25792 0 0 Pathways |TFAP2C| 2|9249 DHRS3 BMP7|LD 655|753|3 GO LRAD4|IN GO:00603 pathway-restricted SMAD protein 624|4089| 1 -1.52649 M1 1 0 Biological 19 -1.52649 2.554163 2.429501 24156 65 873 6 0.687285 0.279617 HBA|SMA -0.36963 0 84 0 0 -3.88473 11.06804 89 phosphorylation 7272|569 Processes D4|TTK|P 37 MEPA1 3958|910 LGALS3|R GO 4|57718|8 GN|PPP4 GO:00353 negative regulation of protein 1 -1.52649 M1 1 0 Biological 19 -1.52649 2.554163 2.429501 24156 65 873 6 0.687285 0.279617 4687|849 R4|PPP1R -0.36963 0 199 0 0 -2.40034 2.76701 08 dephosphorylation Processes 30|39261 9B|MAST 7 L|ELFN1 CALB2|C DH5|CMK 794|1003| LR1|DRD5 1240|181 |EDN2|ED 6|1907|19 N3|FGF2| 08|2247|2 GPR17|LP 840|2846| AR4|GRIA 2890|290 1|GRIN1| 2|3357|51 HTR2B|P GO 56|6387|6 GO:00725 cellular divalent inorganic cation DGFRA|C 1 -1.52499 M1 1 0 Biological 19 -1.52499 1.473556 2.086699 24156 507 873 27 3.092784 0.58593 869|6915| -0.36836 0 94 0 0 -3.67332 2.548562 03 homeostasis XCL12|TA Processes 7223|785 CR1|TBXA 2|9104|10 2R|TRPC4 590|1134 |CXCR4|R 6|22821|3 GN|SCGN 0001|515 |SYNPO|R 54|55013| ASA3|ER 64072|72 O1A|ACK 9230 R4|MCUB| CDH23|C GO 794|9497| CALB2|SL GO:00324 Cellular 53904|64 C4A7|MY 1 -1.34712 M1 1 0 20 stereocilium -1.34712 2.562047 2.225131 24156 54 873 5 0.572738 0.255402 -0.25792 0 0 20 Compone 072|1175 O3A|CDH nts 31 23|TMC1 AGTR2|F 186|2247| GF2|MEF2 4208|558 C|PRKD1| GO 7|6915|70 GO:00435 regulation of blood vessel endothelial cell TBXA2R|T 1 -1.52459 M1 1 0 Biological 19 -1.52459 1.914284 2.239713 24156 159 873 11 1.260023 0.37751 57|28984| -0.36818 0 15 0 0 -9.08083 2.73285 35 migration HBS1|RG Processes 54567|57 CC|DLL4| 381|5760 RHOJ|JCA 8|79812 D|MMRN ACTN1|M 87|4214|5 AP3K1|CL 010|5563| DN11|PR 7074|113 KAA2|TIA KEGG 46|58494| 1 -1.34619 hsa04530 M1 1 0 24 Tight junction -1.34619 1.790418 2.002598 24156 170 873 11 1.260023 0.37751 M1|SYNP -0.25738 0 0 Pathway 79861|84 O|JAM2|T 612|8495 UBAL3|PA 2|100506 RD6B|CG 658 NL1|OCL ALDH1A3 220|1381| |CRABP1| 1382|154 CRABP2| GO GO:00067 5|2239|60 CYP1B1|G 1 -1.52117 M1 1 0 Biological 19 terpenoid metabolic process -1.52117 2.075258 2.286458 24156 120 873 9 1.030928 0.341867 -0.36544 0 131 0 0 -3.08989 10.37629 21 17|8854|9 PC4|RLBP Processes 249|1575 1|ALDH1 06 A2|DHRS 3|RDH10 1021|138 CDK6|CR 5|2200|36 EB1|FBN1 GO GO:00027 regulation of myeloid leukocyte 24|3976|6 |INHBA|LI 1 -1.52117 M1 1 0 Biological 19 -1.52117 2.075258 2.286458 24156 120 873 9 1.030928 0.341867 -0.36544 0 296 0 0 -1.58656 2.075258 61 differentiation 422|8111| F|SFRP1|G Processes 8772|549 PR68|FAD 97 D|TESC ACTN1|L 87|4008|4 MO7|SM KEGG 089|4233| 1 -1.34014 hsa04520 M1 1 0 24 Adherens junction -1.34014 2.305842 2.148739 24156 72 873 6 0.687285 0.279617 AD4|MET| -0.2521 0 0 Pathway 5795|117 PTPRJ|SS 178 X2IP CREB1|D 1385|184 USP7|ME R-HSA- Reactome 9|4208|56 1 -1.34014 M1 1 0 6 Interleukin-17 signaling -1.34014 2.305842 2.148739 24156 72 873 6 0.687285 0.279617 F2C|MAP -0.2521 0 0 448424 Gene Sets 00|8767|1 K11|RIPK2 0454 |TAB1 ADORA2 GO GO:00423 135|136|1 A|ADORA 1 -1.52018 M1 1 0 Biological 19 vasodilation -1.52018 3.353952 2.620174 24156 33 873 4 0.45819 0.22857 -0.36544 0 171 0 0 -2.66202 13.83505 11 86|3672 2B|AGTR2 Processes |ITGA1 CREB1|E2 1385|187 F2|ERG|ES 0|2078|21 RRB|FLI1| 03|2313|4 SMAD4| 089|4208| MEF2C|M 4222|460 EOX1|MY 3|4610|47 BL1|MYCL GO 72|5992|6 GO:00012 DNA-binding transcription activator |NFATC1| 1 -1.33442 M1 1 0 Molecular 21 -1.33442 1.459661 1.875492 24156 436 873 23 2.634593 0.542066 939|7022| -0.24678 0 0 28 activity, RNA polymerase II-specific RFX4|TCF Functions 7029|909 15|TFAP2 6|10736|2 C|TFDP2| 3598|308 TBX18|SIX 12|64641| 2|PATZ1| 93649|14 SOX8|EBF 8979|642 2|MYOCD 658 |GLIS1|SC FGF2|PD GO 2247|515 GO:00435 positive regulation of phosphatidylinositol GFRA|PRK 1 -1.52018 M1 1 0 Biological 19 -1.52018 3.353952 2.620174 24156 33 873 4 0.45819 0.22857 6|5587|38 -0.36544 0 232 0 0 -2.12027 5.534021 52 3-kinase activity D1|TNFAI Processes 8121 P8L3 CAMK2A| 815|1312| COMT|CR 1385|181 EB1|DRD5 KEGG 6|2890|37 1 -1.33293 hsa04728 M1 1 0 24 Dopaminergic synapse -1.33293 1.915623 2.026929 24156 130 873 9 1.030928 0.341867 |GRIA1|K -0.24567 0 0 Pathway 62|5600|7 CNJ5|MA 054|9186 PK11|TH| 0 CALML4 CCN2|EP 1490|204 HB1|EPH 7|2048|22 B2|FGF2|F 47|2324|2 LT4|FN1| 335|3357| HTR2B|LIF 3976|408 |SMAD4| GO GO:00703 9|4916|51 NTRK3|P 1 -1.51945 M1 1 0 Biological 19 ERK1 and ERK2 cascade -1.51945 1.602841 2.128567 24156 328 873 19 2.176403 0.493838 -0.36531 0 18 0 0 -7.89792 2.69514 71 56|7074|7 DGFRA|TI Processes 078|8767| AM1|TIM 10125|56 P3|RIPK2| 034|1521 RASGRP1| 10|28501 PDGFC|N 6|388121 EK10|ALK AL2|TNFA 2239|326 GPC4|HP 3|3958|97 X|LGALS3 23|54437| |SEMA3E| 114899|1 SEMA5B| Canonical 1 -1.33103 M5880 M1 1 0 11 NABA ECM AFFILIATED -1.33103 1.779948 1.981915 24156 171 873 11 1.260023 0.37751 58326|16 C1QTNF3 -0.24415 0 0 Pathways 6752|341 |FREM1|F 640|3926 REM3|FRE 17|49719 M2|ELFN 0 1|CLEC18 ACTN2|A 88|136|98 DORA2B| 3|1894|20 CDK1|ECT 40|5116|5 2|STOM|P GO 174|9585| CNT|PDZ GO:00323 1 -1.5159 M1 1 0 Biological 19 positive regulation of intracellular transport -1.5159 1.752857 2.177124 24156 221 873 14 1.603666 0.425147 22871|23 K1|KIF20B -0.36236 0 224 0 0 -2.14044 2.813909 88 Processes 379|5151 |NLGN1|I 2|55051|8 CE1|GTSE 0184|844 1|NRDE2| 55 CEP290|E FCAB7 355|4214| FAS|MAP Canonical 1 -1.32475 M94 M1 1 0 11 PID FAS PATHWAY -1.32475 2.912642 2.284789 24156 38 873 4 0.45819 0.22857 5600|877 3K1|MAP -0.23923 0 0 Pathways 2 K11|FAD ESRRB|EN 2103|516 PP1|HS2S GO 7|9653|23 GO:00346 T1|PASK|I 1 -1.51582 M1 1 0 Biological 19 cellular carbohydrate biosynthetic process -1.51582 2.333623 2.356667 24156 83 873 7 0.801833 0.301847 178|5147 -0.36236 0 251 0 0 -1.95287 3.29406 37 SYNA1|CS Processes 7|55790|9 GALNACT 3010 1|B3GNT7 CALB2|C MKLR1|E 794|1240| DN2|FGF 1907|224 2|GPR17| 7|2840|28 LPAR4|GR 46|2890|2 IA1|GRIN 902|3357| 1|HTR2B| GO 5156|686 GO:00514 regulation of cytosolic calcium ion PDGFRA| 1 -1.5101 M1 1 0 Biological 19 -1.5101 1.557834 2.10241 24156 373 873 21 2.405498 0.518571 9|6915|72 -0.36035 0 94 0 0 -3.67332 2.548562 80 concentration TACR1|TB Processes 23|7852|1 XA2R|TRP 0590|113 C4|CXCR4 46|22821| |SCGN|SY 30001|51 NPO|RAS 554|6407 A3|ERO1 2|729230 A|ACKR4| CDH23|C ALDH1A3 220|1381| |CRABP1| 1382|154 CRABP2| GO GO:00067 5|2239|60 CYP1B1|G 1 -1.50991 M1 1 0 Biological 19 isoprenoid metabolic process -1.50991 1.976436 2.243616 24156 140 873 10 1.145475 0.360151 -0.36035 0 131 0 0 -3.08989 10.37629 20 17|7054|8 PC4|RLBP Processes 854|9249| 1|TH|ALD 157506 H1A2|DH RS3|RDH GO MICAL2|P 9645|272 GO:00319 Cellular DLIM3|M 1 -1.32475 M1 1 0 20 filamentous actin -1.32475 2.912642 2.284789 24156 38 873 4 0.45819 0.22857 95|53904| -0.23923 0 0 41 Compone YO3A|SPE 92521 nts CC1 2620|400 GAS2|LM R-HSA- Reactome 1 -1.32475 M1 1 0 6 Apoptotic cleavage of cellular proteins -1.32475 2.912642 2.284789 24156 38 873 4 0.45819 0.22857 1|63967|1 NB1|CLSP -0.23923 0 0 111465 Gene Sets 00506658 N|OCLN EPHB1|IT 2047|367 GA2|SERP 3|5270|63 INE2|CXC GO 87|6869|7 GO:00095 L12|TACR 1 -1.50991 M1 1 0 Biological 19 detection of abiotic stimulus -1.50991 1.976436 2.243616 24156 140 873 10 1.145475 0.360151 852|1069 -0.36035 0 151 0 0 -2.8845 27.6701 82 1|CXCR4| Processes 2|54437|1 RRH|SEM 17531|13 A5B|TMC 3060 1|OTOP1 ACTL6A|C 86|835|15 ASP2|CYP 45|5156|5 1B1|PDGF GO 629|3081 GO:00600 RA|PROX 1 -1.50991 M1 1 0 Biological 19 retina development in camera-type eye -1.50991 1.976436 2.243616 24156 140 873 10 1.145475 0.360151 2|54567|5 -0.36035 0 189 0 0 -2.46134 9.223368 41 1|SOX8|D Processes 6890|573 LL4|MDM 81|28421 1|RHOJ|L 7 AMA1 3706|707 ITPKA|TIA GO GO:00610 regulation of dendritic spine 4|22871|2 M1|NLGN 1 -1.50382 M1 1 0 Biological 19 -1.50382 2.82348 2.474108 24156 49 873 5 0.572738 0.255402 -0.36035 0 107 0 0 -3.41128 3.074456 01 morphogenesis 3237|260 1|ARC|SIP Processes 37 A1L1 FGF2|HTR 2247|335 GO 2B|PDGFR GO:19037 positive regulation of phospholipid 7|5156|55 1 -1.50382 M1 1 0 Biological 19 -1.50382 2.82348 2.474108 24156 49 873 5 0.572738 0.255402 A|PRKD1| -0.36035 0 232 0 0 -2.12027 5.534021 27 metabolic process 87|38812 Processes TNFAIP8L 1 3 2040|865 STOM|DY GO 5|22918|7 NLL1|CD9 GO:00708 Cellular 1 -1.31576 M1 1 0 20 tertiary granule membrane -1.31576 2.274255 2.111318 24156 73 873 6 0.687285 0.279617 9895|816 3|ATP8B4 -0.23909 0 0 21 Compone 19|19652 |TSPAN14 nts 7 |ANO6 CDKN2B| 1030|408 SMAD4|S R-HSA- Reactome 9|6498|70 1 -1.31576 M1 1 0 6 Signaling by TGF-beta Receptor Complex -1.31576 2.274255 2.111318 24156 73 873 6 0.687285 0.279617 KIL|TFDP2 -0.23909 0 0 170834 Gene Sets 29|56937| |PMEPA1| 64750 SMURF2 DNMT3B| 1789|301 H2AZ1|R R-HSA- Reactome 5|5931|83 1 -1.31576 M1 1 0 6 PRC2 methylates histones and DNA -1.31576 2.274255 2.111318 24156 73 873 6 0.687285 0.279617 BBP7|H3C -0.23909 0 0 212300 Gene Sets 57|8726|6 10|EED|H 53604 3C13 BRCA1|FA 672|2187| NCB|HIC1 3090|536 |PMAIP1| 6|6387|64 CXCL12|S 98|27063| GO KIL|ANKR GO:20010 regulation of response to DNA damage 54780|55 1 -1.50164 M1 1 0 Biological 19 -1.50164 1.744961 2.159205 24156 222 873 14 1.603666 0.425147 D1|NSMC -0.36035 0 262 0 0 -1.9094 4.368964 20 stimulus 010|5503 Processes E4A|PARP 1|55137|5 BP|USP47 5183|839 |FIGN|RIF 33|40172 1|HDAC1 0 0|FIGNL2 675|2335| BRCA2|F 3690|415 N1|ITGB3| GO GO:00020 5|7078|70 MBP|TIM 1 -1.31548 M1 1 0 Molecular 21 protease binding -1.31548 1.900999 2.002256 24156 131 873 9 1.030928 0.341867 -0.23909 0 0 20 79|8767|8 P3|TIMP4| Functions 772|1473 RIPK2|FA 72 DD|CCBE CORUM:2 SWI-SNF chromatin remodeling-related- ACTL6A|B 1 -1.31491 M1 1 0 CORUM 33 -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 86|672 -0.23909 0 0 38 BRCA1 complex RCA1 CORUM:3 SRCAP-associated chromatin remodeling ACTL6A| 1 -1.31491 M1 1 0 CORUM 33 -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 86|3015 -0.23909 0 0 04 complex H2AZ1 mRNA decay complex (UPF1, UPF2, UPF3B, CORUM:8 5073|544 PARN|XR 1 -1.31491 M1 1 0 CORUM 33 DCP2, XRN1, XRN2, EXOSC2, EXOSC4, -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 22 64 N1 EXOSC10, PARN) GO GO:19028 positive regulation of non-motile cilium 9662|558 CEP135|C 1 -1.50026 M1 1 0 Biological 19 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 19 0 0 -7.81934 13.83505 57 assembly 35 ENPJ Processes GO GO:00485 post-embryonic animal organ 2200|423 FBN1|MF 1 -1.50026 M1 1 0 Biological 19 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 24 0 0 -7.35548 20.75258 63 morphogenesis 7 AP2 Processes GO GO:19903 cellular response to insulin-like growth 1385|220 CREB1|FB 1 -1.50026 M1 1 0 Biological 19 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 24 0 0 -7.35548 20.75258 14 factor stimulus 0 N1 Processes GO GO:00466 672|5689 BRCA1|M 1 -1.50026 M1 1 0 Biological 19 negative regulation of centriole replication -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 70 0 0 -4.32747 27.6701 00 0 DM1 Processes GO GO:00850 BARD1|B 1 -1.50026 M1 1 0 Biological 19 protein K6-linked ubiquitination -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 580|672 -0.36035 0 70 0 0 -4.32747 27.6701 20 RCA1 Processes GO GO:00309 5629|801 PROX1|C 1 -1.50026 M1 1 0 Biological 19 otic vesicle formation -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 92 0 0 -3.73382 12.29782 16 84 EP290 Processes GO GO:00722 metanephric nephron tubule 3280|308 HES1|SO 1 -1.50026 M1 1 0 Biological 19 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 118 0 0 -3.28677 7.905744 82 morphogenesis 12 X8 Processes GO GO:00722 metanephric glomerulus vasculature CD34|PD 1 -1.50026 M1 1 0 Biological 19 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 947|5156 -0.36035 0 119 0 0 -3.27941 18.44674 39 development GFRA Processes GO GO:19000 947|7967 CD34|VT 1 -1.50026 M1 1 0 Biological 19 regulation of interleukin-2 secretion -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 119 0 0 -3.27941 18.44674 40 9 CN1 Processes GO GO:00071 6790|931 AURKA|T 1 -1.50026 M1 1 0 Biological 19 female meiosis I -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 128 0 0 -3.12886 18.44674 44 9 RIP13 Processes GO GO:00356 5175|729 PECAM1| 1 -1.50026 M1 1 0 Biological 19 monocyte extravasation -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 152 0 0 -2.8845 27.6701 96 230 CCR2 Processes GO GO:00357 58494|72 JAM2|CC 1 -1.50026 M1 1 0 Biological 19 hematopoietic stem cell migration -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 152 0 0 -2.8845 27.6701 01 9230 R2 Processes GO GO:19024 negative regulation of stem cell population BMP7|LO 1 -1.50026 M1 1 0 Biological 19 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 655|4017 -0.36035 0 153 0 0 -2.8845 27.6701 55 maintenance XL2 Processes GO GO:20001 AGTR2|T 1 -1.50026 M1 1 0 Biological 19 negative regulation of fatty acid transport -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 186|7057 -0.36035 0 163 0 0 -2.77297 7.905744 92 HBS1 Processes GO GO:00510 negative regulation of membrane protein 7078|707 TIMP3|TI 1 -1.50026 M1 1 0 Biological 19 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 172 0 0 -2.66202 6.917526 45 ectodomain proteolysis 9 MP4 Processes GO GO:00067 6017|885 RLBP1|AL 1 -1.50026 M1 1 0 Biological 19 vitamin A metabolic process -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 173 0 0 -2.66202 6.917526 76 4 DH1A2 Processes GO GO:20006 positive regulation of histone H3-K9 BRCA1|S 1 -1.50026 M1 1 0 Biological 19 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 672|4089 -0.36035 0 184 0 0 -2.53893 6.917526 17 acetylation MAD4 Processes GO GO:20009 positive regulation of AMPA receptor 10369|23 CACNG2| 1 -1.50026 M1 1 0 Biological 19 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 194 0 0 -2.41795 18.44674 69 activity 237 ARC Processes GO GO:00487 4089|803 SMAD4| 1 -1.50026 M1 1 0 Biological 19 sebaceous gland development -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 197 0 0 -2.41795 18.44674 33 26 WNT10A Processes GO GO:00709 Cellular 9585|544 KIF20B|A 1 -1.31491 M1 1 0 20 contractile ring -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 38 Compone 43 NLN nts GO GO:00050 transforming growth factor beta receptor, 4089|409 SMAD4|S 1 -1.31491 M1 1 0 Molecular 21 -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 72 cytoplasmic mediator activity 0 MAD5 Functions GO GO:00053 81031|85 SLC2A10| 1 -1.31491 M1 1 0 Molecular 21 carbohydrate:proton symporter activity -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 51 414 SLC45A3 Functions GO GO:00082 single-stranded DNA 9156|926 EXO1|MG 1 -1.31491 M1 1 0 Molecular 21 -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 97 exodeoxyribonuclease activity 67 ME1 Functions GO GO:00199 4155|535 MBP|PLP 1 -1.31491 M1 1 0 Molecular 21 structural constituent of myelin sheath -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 11 4 1 Functions GO GO:00469 histone methyltransferase activity (H3-K9 2122|797 MECOM| 1 -1.31491 M1 1 0 Molecular 21 -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 74 specific) 23 SUV39H2 Functions GO GO:00518 54464|80 XRN1|PIF 1 -1.31491 M1 1 0 Molecular 21 G-quadruplex DNA binding -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 80 119 1 Functions R-HSA- Reactome 983|8493 CDK1|MA 1 -1.31491 M1 1 0 6 MASTL Facilitates Mitotic Progression -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 2465910 Gene Sets 0 STL

R-HSA- Reactome Role of second messengers in netrin-1 7223|942 TRPC4|NT 1 -1.31491 M1 1 0 6 -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 418890 Gene Sets signaling 3 N1 CREB1 phosphorylation through the R-HSA- Reactome 1385|383 CREB1|KP 1 -1.31491 M1 1 0 6 activation of CaMKII/CaMKK/CaMKIV -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 442729 Gene Sets 8 NA2 cascasde SLC22A1 R-HSA- Reactome 5002|854 1 -1.31491 M1 1 0 6 Organic cation transport -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 8|SLC22A -0.23909 0 0 549127 Gene Sets 13 16 R-HSA- Reactome 3931|938 LCAT|LIP 1 -1.31491 M1 1 0 6 HDL remodeling -1.31491 5.534021 2.776848 24156 10 873 2 0.229095 0.161809 -0.23909 0 0 8964058 Gene Sets 8 G GO GO:00032 cardiac neural crest cell migration involved BMP7|PIT 1 -1.50026 M1 1 0 Biological 19 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 655|5308 -0.36035 0 198 0 0 -2.41795 18.44674 53 in outflow tract morphogenesis X2 Processes GO GO:00466 5002|517 SLC22A1 1 -1.50026 M1 1 0 Biological 19 drug export -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 209 0 0 -2.2632 11.06804 18 4 8|PDZK1 Processes GO GO:19909 5002|517 SLC22A1 1 -1.50026 M1 1 0 Biological 19 drug transmembrane export -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 209 0 0 -2.2632 11.06804 61 4 8|PDZK1 Processes GO heparan sulfate proteoglycan biosynthetic HS2ST1|C GO:00150 9653|557 1 -1.50026 M1 1 0 Biological 19 process, polysaccharide chain biosynthetic -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 SGALNAC -0.36035 0 228 0 0 -2.12745 13.83505 14 90 Processes process T1 GO GO:00456 regulation of inner ear auditory receptor 3280|461 HES1|MY 1 -1.50026 M1 1 0 Biological 19 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 240 0 0 -2.05201 6.917526 07 cell differentiation 0 CL Processes GO GO:00456 regulation of mechanoreceptor 3280|461 HES1|MY 1 -1.50026 M1 1 0 Biological 19 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 240 0 0 -2.05201 6.917526 31 differentiation 0 CL Processes GO GO:20009 regulation of inner ear receptor cell 3280|461 HES1|MY 1 -1.50026 M1 1 0 Biological 19 -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 240 0 0 -2.05201 6.917526 80 differentiation 0 CL Processes GO GO:00021 1393|517 CRHBP|PE 1 -1.50026 M1 1 0 Biological 19 aggressive behavior -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 271 0 0 -1.81429 7.905744 18 9 NK Processes GO GO:00063 8318|551 CDC45|RI 1 -1.50026 M1 1 0 Biological 19 chromatin silencing at telomere -1.50026 6.917526 3.241423 24156 8 873 2 0.229095 0.161809 -0.36035 0 286 0 0 -1.65943 6.917526 48 83 F1 Processes CDH5|ME 1003|423 T|PECAM GO GO:00018 3|5175|71 1|TNFRSF 1 -1.49805 M1 1 0 Biological 19 endothelial cell development -1.49805 2.515464 2.387208 24156 66 873 6 0.687285 0.279617 -0.3588 0 127 0 0 -3.17736 9.223368 85 32|26084| 1A|ARHG Processes 64102 EF26|TN MD 1003|189 CDH5|EC GO 4|5175|10 T2|PECA GO:00432 1 -1.49805 M1 1 0 Biological 19 apical junction assembly -1.49805 2.515464 2.387208 24156 66 873 6 0.687285 0.279617 266|8461 M1|RAMP -0.3588 0 132 0 0 -3.08964 3.175258 97 Processes 2|100506 2|PARD6B 658 |OCLN AGTR2|B 186|655|2 MP7|GPC 239|2535| 4|FZD2|LI 3976|642 GO F|SFRP1|T GO:19053 regulation of morphogenesis of an 2|7074|10 1 -1.49515 M1 1 0 Biological 19 -1.49515 1.834482 2.182067 24156 181 873 12 1.37457 0.394068 IAM1|SIX -0.35632 0 10 0 0 -10.1376 3.952872 30 epithelium 736|2321 Processes 2|SULF1|S 3|30812|6 OX8|SMU 4750|144 RF2|PRIC 165 KLE1 GO ITGB3|PD GO:00315 Cellular 3690|517 1 -1.31281 M1 1 0 20 microvillus membrane -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 ZK1|POD -0.23909 0 0 28 Compone 4|5420 XL nts GO GO:00051 5167|664 ENPP1|S 1 -1.31281 M1 1 0 Molecular 21 insulin receptor binding -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 -0.23909 0 0 58 2|55023 NX1|PHIP Functions GO CAMK2A| GO:00099 calcium-dependent protein 815|5587| 1 -1.31281 M1 1 0 Molecular 21 -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 PRKD1|PK -0.23909 0 0 31 serine/threonine kinase activity 29941 Functions N3 GO 7852|515 CXCR4|A GO:00164 1 -1.31281 M1 1 0 Molecular 21 C-C chemokine receptor activity -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 54|72923 CKR4|CC -0.23909 0 0 93 Functions 0 R2 GO 29091|29 STXBP6|P GO:00170 1 -1.31281 M1 1 0 Molecular 21 GTP-Rho binding -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 941|5444 KN3|ANL -0.23909 0 0 49 Functions 3 N R-HSA- Reactome 2157|281 F8|GP5|SE 1 -1.31281 M1 1 0 6 Intrinsic Pathway of Fibrin Clot Formation -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 -0.23909 0 0 140837 Gene Sets 4|5270 RPINE2 SMAD4|S R-HSA- Reactome Downregulation of SMAD2/3:SMAD4 4089|649 1 -1.31281 M1 1 0 6 -1.31281 3.609144 2.424083 24156 23 873 3 0.343643 0.198061 KIL|SMUR -0.23909 0 0 2173795 Gene Sets transcriptional activity 8|64750 F2 H2AZ1|H 3015|307 ELLS|CDC 0|8318|83 45|H3C10 GO 57|8726|5 GO:00063 |EED|NRD 1 -1.49164 M1 1 0 Biological 19 chromatin silencing -1.49164 1.962419 2.219338 24156 141 873 10 1.145475 0.360151 5051|551 -0.35328 0 248 0 0 -1.96848 2.142202 42 E2|RIF1|R Processes 83|55196| ESF1|MA 55506|65 CROH2A 3604 2|H3C13 EPHB1|EP 2047|204 HB2|ITPK GO 8|3706|70 GO:00970 A|TIAM1| 1 -1.49123 M1 1 0 Biological 19 dendritic spine organization -1.49123 2.305842 2.321482 24156 84 873 7 0.801833 0.301847 74|22871| -0.35328 0 107 0 0 -3.41128 3.074456 61 NLGN1|A Processes 23237|26 RC|SIPA1 037 L1 ESRRB|HR 2103|326 H1|PMAI GO 9|5366|55 GO:00459 positive regulation of carbohydrate P1|PRKAA 1 -1.49123 M1 1 0 Biological 19 -1.49123 2.305842 2.321482 24156 84 873 7 0.801833 0.301847 63|9104|1 -0.35328 0 251 0 0 -1.95287 3.29406 13 metabolic process 2|RGN|PP Processes 0891|854 ARGC1A| 14 SLC45A3 ACTN2|A DORA2A| CAMK2A| 88|135|81 CHRM3|C 5|1131|12 NN3|DAB 66|1600|2 1|GRIA1| 890|2902| GRIN1|GR GO 2913|517 M3|PENK| GO:00989 Cellular 9|6456|70 1 -1.30953 M1 1 0 20 neuron to neuron synapse -1.30953 1.495681 1.860518 24156 370 873 20 2.290951 0.50637 SH3GL2|T -0.23656 0 0 84 Compone 74|8537|1 IAM1|BC nts 0369|113 AS1|CAC 46|22871| NG2|SYN 23237|26 PO|NLGN 037|5753 1|ARC|SIP 7|84687 A1L1|SOR CS2|PPP1 R9B CDK6|ME 1021|420 F2C|ENPP GO 8|5167|64 GO:00302 1|SFRP1|T 1 -1.49123 M1 1 0 Biological 19 negative regulation of ossification -1.49123 2.305842 2.321482 24156 84 873 7 0.801833 0.301847 22|11758 -0.35328 0 306 1 1 -1.49123 2.305842 79 WIST2|RA Processes 1|202151| NBP3L|RF 359845 LNB CDK1|ECT 983|1894| 2|STOM|E 2040|204 PHB2|LG 8|3958|39 ALS3|LIF| 76|5116|5 PCNT|PD 174|5366| ZK1|PMAI GO GO:19038 positive regulation of cellular protein 5563|702 P1|PRKAA 1 -1.48507 M1 1 0 Biological 19 -1.48507 1.588314 2.086882 24156 331 873 19 2.176403 0.493838 -0.34756 0 224 0 0 -2.14044 2.813909 29 localization 9|9585|10 2|TFDP2| Processes 369|1040 KIF20B|C 3|23379|5 ACNG2|N 1512|801 DC80|ICE 84|84455| 1|GTSE1| 84687 CEP290|E FCAB7|PP BRCA1|BR 672|675|1 CA2|CREB 385|1789| 1|DNMT3 1894|290 B|ECT2|G 2|3269|38 RIN1|HRH 61|5179|6 1|KRT14|P 387|6422| ENK|CXCL GO 7054|705 12|SFRP1| GO:00093 1 -1.48369 M1 1 0 Biological 19 response to radiation -1.48369 1.499058 2.052818 24156 443 873 24 2.749141 0.553399 6|7520|10 TH|THBD| -0.34639 0 274 0 0 -1.7864 3.458763 14 Processes 206|1027 XRCC5|TR 6|10413|1 IM13|NET 0692|113 1|YAP1|R 46|51514| RH|SYNP 54437|55 O|DTL|SE 031|9042 MA5B|US 7|164312 P47|BMF| LRRN4 ALOX5|C 240|1036| DO1|CYP 1545|158 GO 1B1|CYP1 GO:00055 3|1591|25 1 -1.30483 M1 1 0 Molecular 21 iron ion binding -1.30483 1.820402 1.964706 24156 152 873 10 1.145475 0.360151 1A1|CYP2 -0.2328 0 0 06 12|3039|6 Functions 4A1|FTL| 241|7054| HBA1|RR 55214 M2|TH|P3 CAMK2A| KCNJ2|KC 815|3759| NJ5|MEF2 3762|420 C|NFATC KEGG 8|4772|53 1 -1.30483 hsa04921 M1 1 0 24 Oxytocin signaling pathway -1.30483 1.820402 1.964706 24156 152 873 10 1.145475 0.360151 1|PLA2G4 -0.2328 0 0 Pathway 21|5563|1 A|PRKAA 0369|571 2|CACNG 72|91860 2|CAMK1 G|CALML EDN2|PR GO 1907|556 GO:00970 KAA2|PP 1 -1.47801 M1 1 0 Biological 19 energy homeostasis -1.47801 3.255306 2.548176 24156 34 873 4 0.45819 0.22857 3|10891|2 -0.34267 0 90 0 0 -3.74989 8.301031 09 ARGC1A| Processes 3178 PASK