Understanding Major Depressive Disorder
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Dietary Patterns Are Differentially Associated with Atypical and Melancholic Subtypes of Depression
nutrients Article Dietary Patterns Are Differentially Associated with Atypical and Melancholic Subtypes of Depression Aurélie M. Lasserre 1,* , Marie-Pierre F. Strippoli 1 , Pedro Marques-Vidal 2 , Lana J. Williams 3, Felice N. Jacka 3, Caroline L. Vandeleur 1, Peter Vollenweider 2 and Martin Preisig 1 1 Department of Psychiatry, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland; [email protected] (M.-P.F.S.); [email protected] (C.L.V.); [email protected] (M.P.) 2 Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland; [email protected] (P.M.-V.); [email protected] (P.V.) 3 Barwon Health, IMPACT—The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong 3220, Australia; [email protected] (L.J.W.); [email protected] (F.N.J.) * Correspondence: [email protected]; Tel.: +41-21-314-3552 Abstract: Diet has been associated with the risk of depression, whereas different subtypes of depres- sion have been linked with different cardiovascular risk factors (CVRFs). In this study, our aims were to (1) identify dietary patterns with exploratory factor analysis, (2) assess cross-sectional associations between dietary patterns and depression subtypes, and (3) examine the potentially mediating effect of dietary patterns in the associations between CVRFs and depression subtypes. In the first follow-up of the population-based CoLaus|PsyCoLaus study (2009–2013, 3554 participants, 45.6% men, mean age Citation: Lasserre, A.M.; Strippoli, 57.5 years), a food frequency questionnaire assessed dietary intake and a semi-structured interview M.-P.F.; Marques-Vidal, P.; Williams, allowed to characterize major depressive disorder into current or remitted atypical, melancholic, L.J.; Jacka, F.N.; Vandeleur, C.L.; and unspecified subtypes. -
Alteration of Immune Markers in a Group of Melancholic Depressed Patients and Their Response to Electroconvulsive Therapy
HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author J Affect Manuscript Author Disord. Author Manuscript Author manuscript; available in PMC 2017 February 03. Published in final edited form as: J Affect Disord. 2016 November 15; 205: 60–68. doi:10.1016/j.jad.2016.06.035. Alteration of Immune Markers in a group of Melancholic Depressed patients and their Response to Electroconvulsive Therapy Gavin Rush1,*, Aoife O’Donovan2,3,4,5, Laura Nagle1, Catherine Conway1, AnnMaria McCrohan2,3, Cliona O’Farrelly6, James V. Lucey1, and Kevin M. Malone2,3 1St. Patrick’s University Hospital, Dublin, Ireland 2School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland 3Department of Psychiatry, Psychotherapy and Mental Health Research, St. Vincent’s University Hospital, Dublin, Ireland 4Stress and Health Research Program, San Francisco Veteran’s Affairs Medical Center, San Francisco, California 5Department of Psychiatry, University of California, San Francisco, California 6School of Biochemistry and Immunology, University of Dublin Trinity College, Dublin, Ireland Abstract Background—Immune system dysfunction is implicated in the pathophysiology of major depression, and is hypothesized to normalize with successful treatment. We aimed to investigate immune dysfunction in melancholic depression and its response to ECT. Methods—55 melancholic depressed patients and 26 controls participated. 33 patients (60%) were referred for ECT. Blood samples were taken at baseline, one hour after the first ECT session, and 48 hours after ECT series completion. Results—At baseline, melancholic depressed patients had significantly higher levels of the pro- inflammatory cytokine IL-6, and lower levels of the regulatory cytokine TGF-β than controls. A significant surge in IL-6 levels was observed one hour after the first ECT session, but neither IL-6 nor TGF-β levels normalized after completion of ECT series. -
Neuroticism, BIS, and Reactivity to Discrete Negative Mood Inductions ⇑ Jennifer Thake, John M
Personality and Individual Differences 54 (2013) 208–213 Contents lists available at SciVerse ScienceDirect Personality and Individual Differences journal homepage: www.elsevier.com/locate/paid Neuroticism, BIS, and reactivity to discrete negative mood inductions ⇑ Jennifer Thake, John M. Zelenski Department of Psychology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6 article info abstract Article history: Research has established relationships between the personality dimensions of neuroticism and BIS and Received 5 March 2012 broad negative emotional reactivity. However, few researchers have examined the relationships among Received in revised form 4 August 2012 neuroticism, BIS, and discrete negative emotional reactivities. The present study examined whether indi- Accepted 27 August 2012 viduals scoring high on neuroticism and BIS were more reactive across four discrete negative mood Available online 25 September 2012 inductions, relative to those scoring low on these traits. Participants (n = 166) completed personality questionnaires, measures of current mood, viewed a specific mood-inducing film clip (sadness, anger, Keywords: fear or disgust) and then reported their moods a second time. Results revealed that neuroticism/BIS Neuroticism was associated with high reactivity to the fear and sadness inductions. Neuroticism/BIS did not predict Behavioral inhibition system Mood anger or disgust reactivity, but neuroticism/BIS and extraversion/BAS interacted in predicting anger. Emotion Although further research is -
Specificity of Psychosis, Mania and Major Depression in A
Molecular Psychiatry (2014) 19, 209–213 & 2014 Macmillan Publishers Limited All rights reserved 1359-4184/14 www.nature.com/mp ORIGINAL ARTICLE Specificity of psychosis, mania and major depression in a contemporary family study CL Vandeleur1, KR Merikangas2, M-PF Strippoli1, E Castelao1 and M Preisig1 There has been increasing attention to the subgroups of mood disorders and their boundaries with other mental disorders, particularly psychoses. The goals of the present paper were (1) to assess the familial aggregation and co-aggregation patterns of the full spectrum of mood disorders (that is, bipolar, schizoaffective (SAF), major depression) based on contemporary diagnostic criteria; and (2) to evaluate the familial specificity of the major subgroups of mood disorders, including psychotic, manic and major depressive episodes (MDEs). The sample included 293 patients with a lifetime diagnosis of SAF disorder, bipolar disorder and major depressive disorder (MDD), 110 orthopedic controls, and 1734 adult first-degree relatives. The diagnostic assignment was based on all available information, including direct diagnostic interviews, family history reports and medical records. Our findings revealed specificity of the familial aggregation of psychosis (odds ratio (OR) ¼ 2.9, confidence interval (CI): 1.1–7.7), mania (OR ¼ 6.4, CI: 2.2–18.7) and MDEs (OR ¼ 2.0, CI: 1.5–2.7) but not hypomania (OR ¼ 1.3, CI: 0.5–3.6). There was no evidence for cross-transmission of mania and MDEs (OR ¼ .7, CI:.5–1.1), psychosis and mania (OR ¼ 1.0, CI:.4–2.7) or psychosis and MDEs (OR ¼ 1.0, CI:.7–1.4). -
Social Psychoneuroimmunology: Understanding Bidirectional Links Between Social Experiences and the Immune System
Brain, Behavior, and Immunity xxx (xxxx) xxx Contents lists available at ScienceDirect Brain Behavior and Immunity journal homepage: www.elsevier.com/locate/ybrbi Viewpoint Social psychoneuroimmunology: Understanding bidirectional links between social experiences and the immune system Keely A. Muscatell University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Does the immune system have a “social life,” wherein our social have historically signaled) increased likelihood of injury (e.g., ostra experiences can affect and be affected by the activities of the immune cism) or infection (e.g., socially connecting with others) will lead to system? Research in the nascent subfield of social psychoneuroimmunol changes in the activities of the immune system (Kemeny, 2009; Eisen ogy suggests that the answer to this question is a resounding “yes” – there berger et al., 2017; Gassen and Hill, 2019; Slavich and Cole, 2013; are profound bidirectional connections between social experiences and Leschak and Eisenberger, 2019). The second core tenant is that the brain the immune system. Yet there are also vast opportunities for discovery in is constantly monitoring the physiological state of the body and inte this new subfield. In this article, I briefly define and outline some core grating this information with signals from the broader environment to tenants of social psychoneuroimmunology (Fig. 1). I also highlight op gauge metabolic demands and guide adaptive behavior (Sterling, 2012). portunities for future work in this area. Bringing together social psy As such, even relatively minor fluctuationsin immune system activation chological and psychoneuroimmunology research will undoubtedly lead outside of an experience of acute illness, injury, or chronic disease, can to important discoveries about the interconnections between the im feed back to the brain to guide social cognition and behavior. -
Stress, Emotion Regulation, and Well-Being Among Canadian Faculty Members in Research-Intensive Universities
social sciences $€ £ ¥ Article Stress, Emotion Regulation, and Well-Being among Canadian Faculty Members in Research-Intensive Universities Raheleh Salimzadeh *, Nathan C. Hall and Alenoush Saroyan Department of Educational and Counselling Psychology, McGill University, Montreal, QC H3A 1Y2, Canada; [email protected] (N.C.H.); [email protected] (A.S.) * Correspondence: [email protected] Received: 22 September 2020; Accepted: 25 November 2020; Published: 10 December 2020 Abstract: Existing research reveals the academic profession to be stressful and emotion-laden. Recent evidence further shows job-related stress and emotion regulation to impact faculty well-being and productivity. The present study recruited 414 Canadian faculty members from 13 English-speaking research-intensive universities. We examined the associations between perceived stressors, emotion regulation strategies, including reappraisal, suppression, adaptive upregulation of positive emotions, maladaptive downregulation of positive emotions, as well as adaptive and maladaptive downregulation of negative emotions, and well-being outcomes (emotional exhaustion, job satisfaction, quitting intentions, psychological maladjustment, and illness symptoms). Additionally, the study explored the moderating role of stress, gender, and years of experience in the link between emotion regulation and well-being as well as the interactions between adaptive and maladaptive emotion regulation strategies in predicting well-being. The results revealed that cognitive reappraisal was a health-beneficial strategy, whereas suppression and maladaptive strategies for downregulating positive and negative emotions were detrimental. Strategies previously defined as adaptive for downregulating negative emotions and upregulating positive emotions did not significantly predict well-being. In contrast, strategies for downregulating negative emotions previously defined as dysfunctional showed the strongest maladaptive associations with ill health. -
Dysphoria As a Complex Emotional State and Its Role in Psychopathology
Dysphoria as a complex emotional state and its role in psychopathology Vladan Starcevic A/Professor, University of Sydney Faculty of Medicine and Health Sydney, Australia Objectives • Review conceptualisations of dysphoria • Present dysphoria as a transdiagnostic complex emotional state and assessment of dysphoria based on this conceptualisation What is dysphoria? • The term is derived from Greek (δύσφορος) and denotes distress that is hard to bear Dysphoria: associated with externalisation? • “Mixed affect” leading to an “affect of suspicion”1,2 1 Sandberg: Allgemeine Zeitschrift für Psychiatrie und Psychisch-Gerichtl Medizin 1896; 52:619-654 2 Specht G: Über den pathologischen Affekt in der chronischen Paranoia. Festschrift der Erlanger Universität, 1901 • A syndrome that always includes irritability and at least two of the following: internal tension, suspiciousness, hostility and aggressive or destructive behaviour3 3 Dayer et al: Bipolar Disord 2000; 2: 316-324 Dysphoria: associated with internalisation? • Six “dysphoric symptoms”: depressed mood, anhedonia, guilt, suicide, fatigue and anxiety1 1 Cassidy et al: Psychol Med 2000; 30:403-411 Dysphoria: a nonspecific state? • Dysphoria is a “nonspecific syndrome” and has “no particular place in a categorical diagnostic system”1; it is neglected and treated like an “orphan”1 1 Musalek et al: Psychopathol 2000; 33:209-214 • Dysphoria “can refer to many ways of feeling bad”2 2 Swann: Bipolar Disord 2000; 2:325-327 Textbook definitions: dysphoria nonspecific, mainly internalising? • “Feeling -
Which Is It: ADHD, Bipolar Disorder, Or PTSD?
HEALINGHEALINGA PUBLICATION OF THE HCH CLINICIANS’ HANDSHANDS NETWORK Vol. 10, No. 3 I August 2006 Which Is It: ADHD, Bipolar Disorder, or PTSD? Across the spectrum of mental health care, Anxiety Disorders, Attention Deficit Hyperactivity Disorders, and Mood Disorders often appear to overlap, as well as co-occur with substance abuse. Learning to differentiate between ADHD, bipolar disorder, and PTSD is crucial for HCH clinicians as they move toward integrated primary and behavioral health care models to serve homeless clients. The primary focus of this issue is differential diagnosis. Readers interested in more detailed clinical information about etiology, treatment, and other interventions are referred to a number of helpful resources listed on page 6. HOMELESS PEOPLE & BEHAVIORAL HEALTH Close to a symptoms exhibited by clients with ADHD, bipolar disorder, or quarter of the estimated 200,000 people who experience long-term, PTSD that make definitive diagnosis formidable. The second chronic homelessness each year in the U.S. suffer from serious mental causative issue is how clients’ illnesses affect their homelessness. illness and as many as 40 percent have substance use disorders, often Understanding that clinical and research scientists and social workers with other co-occurring health problems. Although the majority of continually try to tease out the impact of living circumstances and people experiencing homelessness are able to access resources comorbidities, we recognize the importance of causal issues but set through their extended family and community allowing them to them aside to concentrate primarily on how to achieve accurate rebound more quickly, those who are chronically homeless have few diagnoses in a challenging care environment. -
A Comprehensive Model of Stress-Induced Binge Eating: the Role of Cognitive Restraint, Negative Affect, and Impulsivity in Binge Eating As a Response to Stress
The University of Maine DigitalCommons@UMaine Electronic Theses and Dissertations Fogler Library Summer 8-21-2020 A Comprehensive Model of Stress-induced Binge Eating: The Role of Cognitive Restraint, Negative Affect, and Impulsivity In Binge Eating as a Response to Stress Rachael M. Huff [email protected] Follow this and additional works at: https://digitalcommons.library.umaine.edu/etd Part of the Psychological Phenomena and Processes Commons, and the Women's Health Commons Recommended Citation Huff, Rachael M., "A Comprehensive Model of Stress-induced Binge Eating: The Role of Cognitive Restraint, Negative Affect, and Impulsivity In Binge Eating as a Response to Stress" (2020). Electronic Theses and Dissertations. 3238. https://digitalcommons.library.umaine.edu/etd/3238 This Open-Access Thesis is brought to you for free and open access by DigitalCommons@UMaine. It has been accepted for inclusion in Electronic Theses and Dissertations by an authorized administrator of DigitalCommons@UMaine. For more information, please contact [email protected]. Running head: A COMPREHENSIVE MODEL OF STRESS-INDUCED BINGE EATING A COMPREHENSIVE MODEL OF STRESS-INDUCED BINGE EATING: THE ROLE OF COGNITIVE RESTRAINT, NEGATIVE AFFECT, AND IMPULSIVITY IN BINGE EATING AS A RESPONSE TO STRESS By Rachael M. Huff B.A., Michigan Technological University, 2014 M.A., University of Maine, 2016 A DISSERTATION Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy (in Clinical Psychology) The Graduate School The University of Maine August 2020 Advisory Committee: Shannon K. McCoy, Associate Professor of Psychology, Chair Emily A. P. Haigh, Assistant Professor of Psychology Shawn W. -
Reward and Emotion: an Affective Neuroscience Approach
Reward and emotion: An affective neuroscience approach David Sander1 & Lauri Nummenmaa2 1Swiss Center for Affective Sciences (CISA), Campus Biotech, and Laboratory for the Study of Emotion Elicitation and Expression, Department of Psychology, Faculty of Psychology and Educational Sciences (FPSE), University of Geneva, Geneva, Switzerland 2TurKu PET Centre, TurKu University Hospital, and Department of Psychology, University of TurKu, Finland Address Correspondence to: Lauri Nummenmaa Turku PET Centre c/o Turku University Hospital FI-20520 Turku, Finland Email: [email protected] Tel: +358 50 574 7933 Acknowlegements This study was supported by the Academy oF Finland (grants #294897 and #332225), Sigrid Juselius stiftelse and Signe och Anet Gyllenberg’s stiftelse, and by the Swiss National Science Foundation (grant 100019_188966). DS and LN thank Brian Knutson For in-depth discussions concerning several aspects of this paper. Conflicts of interest None Abstract Pleasure and reward are central for motivation, learning, feeling and allostasis. Although reward is without any doubt an affective phenomenon, there is no consensus concerning its relationship with emotion. In this mini-review we discuss this conceptual issue both from the perspective of theories of reward and emotion as well as human systems neuroimaging. We first describe how the reward process can be understood and dissected as intertwined with the emotion process, in particular in light of the appraisal theories, and then discuss how different facets of the reward process can be studied using neuroimaging and neurostimulation techniques. We conclude that future worK needs to focus on mapping the similarities and differences across stimuli and mechanisms that are involved in reward processing and in emotional processing, and propose that an integrative affective sciences approach would provide means for studying the emotional nature of reward. -
Generalized Anxiety Disorder: Practical Assessment and Management MICHAEL G
Generalized Anxiety Disorder: Practical Assessment and Management MICHAEL G. KAVAN, PhD; GARY N. ELSASSER, PharmD; and EUGENE J. BARONE, MD Creighton University School of Medicine, Omaha, Nebraska Generalized anxiety disorder is common among patients in primary care. Affected patients experience excessive chronic anxiety and worry about events and activities, such as their health, family, work, and finances. The anxiety and worry are difficult to control and often lead to physiologic symptoms, including fatigue, muscle tension, restless- ness, and other somatic complaints. Other psychiatric problems (e.g., depression) and nonpsychiatric factors (e.g., endocrine disorders, medication adverse effects, withdrawal) must be considered in patients with possible generalized anxiety disorder. Cognitive behavior therapy and the first-line pharmacologic agents, selective serotonin reuptake inhibitors, are effective treatments. However, evidence suggests that the effects of cognitive behavior therapy may be more durable. Although complementary and alternative medicine therapies have been used, their effectiveness has not been proven in generalized anxiety disorder. Selection of the most appropriate treatment should be based on patient preference, treatment success history, and other factors that could affect adherence and subsequent effective- ness. (Am Fam Physician. 2009;79(9):785-791. Copyright © 2009 American Academy of Family Physicians.) ▲ Patient information: nxiety disorders, such as generalized GAD is 3.1 percent in population-based sur- -
Mood Disorders and Trauma- What Are the Associations? Yael Dvir M.D., Michael Hill B.S, Steven M Hodge M.A., Jean a Frazier M.D
Mood Disorders and Trauma- What are the Associations? Yael Dvir M.D., Michael Hill B.S, Steven M Hodge M.A., Jean A Frazier M.D. University of Massachusetts Medical School, Child and Adolescent psychiatry [email protected] Background Results Mood dysregulation in traumatized children may be misdiagnosed as bipolar disorder (BD) TABLE 1: Demographic data and conversely, the diagnosis of BD overlooked. Note: test statistic is p-value of Chi-square test for categorical data or t-test for continuous data (corrected for unequal variance) BP MD-NOS Statistic* Our aim is to characterize the relationship between trauma and mood dysregulation and Group size (N) 10 10 . pediatric BD by describing the clinical correlates and demographics of children with Gender (number of Females) 4 4 1.0 trauma/abuse and comorbid mood disorders in a community mental health setting. Ethnicity (% Caucasian) 100 78 0.07 Age at time of Interview (mean (SD)) 13.2 (2.5) 12.5 (3.1) 0.6 Number of Siblings (mean (SD)) 2.2 (1.5) 1.8 (1.4) 0.6 Such distinctions may be especially important among individuals with BD given the disproportionably high prevalence of childhood trauma histories (reported in about half of TABLE 2: Types of trauma experienced and the number of incidents by group adult patients with BD, across several studies) coupled with frequent prepubertal onset of Type of Trauma BP MD-NOS affective symptoms (1-4), significantly younger age at bipolar illness onset, as well as Witnessed violence 8 7 Sexual assault or abuse 7 5 higher severity level of symptoms (3).