ST. ANNE‘S UNIVERSITY HOSPITAL BRNO INTERNATIONAL CLINICAL RESEARCH CENTER

CORE FACILITY Biostatistics

HEAD OF CORE FACILITY

KEY INTERESTS Survival Analysis • Mixed Models • Likelihood and Information Theory • Image Analysis (Facial Imaging and Neuroimaging) • Spatio-Temporal Modelling of Biological Signals • Gene Expression Omnibus Query • GO Enrichment Analysis

RESEARCH FOCUS The primary mission of the Biostatistics (BST) is to support FNUSA-ICRC investigators in the conduct of high-quality, innovative health-related research by providing expertise Mgr. Bc. Silvie BĚLAŠKOVÁ, Ph.D. in biostatistics, statistical programming, and data management. BST researchers E-mail: silvie.belaskova�fnusa.cz and staff collaborate with investigators on all aspects of research: study design and Phone: (+420) 543 185 482 grant development; data capture and statistical analysis; interpretation of results and manuscript preparation. The BST team contributes to all types of research, including EDUCATION basic science, clinical, epidemiological, and health services. BST current methodological research interests are in the areas of survival data, 2017:Ph.D. in Applied Mathematics and Biostatistics, Palacký University, Olomouc, clinical trials, and biomarker studies, as motivated by problems that arise in studies of Czech Republic neurologic diseases and cancer. Research activities include study of the high order asymptotics, the saddlepoint 2007:Bc. in Law of Social Security Science, Masaryk University, Brno, Czech Republic approximation for the density and distribution function and study of delayed entry in Cox proportional hazards model. 2002: Mgr. in Theoretical Mathematics and Descriptive Geometry, Masaryk University, Brno, Czech Republic RESEARCH OBJECTIVES TRAINING Study of the accuracy of the p-value for semiparametric models 2013, 2014: Visiting Scientist, Faculty of Applications of mixed models methodology in biomedical research Biostatistics, LSU School of Public Health, Spatio-Temporal Modelling of Biological Signals New Orleans, LA, USA

CREATING THE FUTURE OF MEDICINE

CLINICAL RESEARCH TRANSLATIONAL BASIC RESEARCH CORE FACILITIES RESEARCH CORE FACILITIES Advanced Laboratories for Experimental Medicine and Translational Research

TOP PUBLICATIONS BEST RESULTS Device for Non-Contact Scanning and Regression of Non-Stationary Temperature Fields – Especially in Biological Objects. Covered by the Czech Patent (PV 2012-124). VOLNÝ, O., KRAJINA, A., BĚLAŠKOVÁ, S., BAR, M., CIMFLOVÁ, P., HERZIG, R., SANAK, D., TOMEK, A., KÖCHER, M., ROCEK, M., PADR, TECHNOLOGICAL EQUIPMENT R., CIHLAR, F., NEVŠÍMALOVÁ, M., JURÁK, L., HAVLÍČEK, R., KOVÁŘ, R., ŠEVČÍK, P., SW StatSoft, Inc., 2013. STATISTICA (data analysis software system), version 12. ROHAN, V., FIKSA, J., MENON, B., MIKULÍK, SW SAS Institute Inc., 2011. Base SAS® version 9.4 Procedures Guide. Cary, NC:SAS. R. Mechanical thrombectomy performs similarly in real world practice: a 2016 SW R Development Core Team (2008). nationwide study from the Czech Republic. SW REDCap (Research Electronic Data Capture). Journal of NeuroInterventional Surgery.

BĚLAŠKOVÁ, S., FIŠEROVÁ, S. Improvement OFFERED SERVICES AND EXPERTISE of the Accuracy in Testing the Effect in the The BST researchers and staff are eager to help you to meet the statistical needs of Cox Proportional Hazards Model Using Higher Order Approximations. Filomat. your research. The BST contributes to all types of research including basic science, 2017, 31(18), 5591-5601. clinical, epidemiological, and health services. The areas of expertise include but are not limited to: POMPEIANO, A., HUARANCCA REYES, T., Categorical Data Analysis MOLES, T. M., VILLANI, M., VOLTERRANI, M., Survival Data Analysis GUGLIELMINETTI, L., SCARTAZZA, A. Inter- and intra-specific variability in physiological Longitudinal Data Analysis traits and post-anoxia recovery of Repeated Measures Data Analysis photosynthetic efficiency in grasses under oxygen deprivation. Physiologia Plantarum. Genetic Data Analysis 2017, 161 (3): 385–399. High Dimensional Data Analysis Clinical Trial Design VANÍČKOVÁ, L., NAGY, R., POMPEIANO, Database Design and Management A., KALINOVÁ, B. Epicuticular chemistry reinforces the new taxonomic classification of the Bactrocera dorsalis species complex (Diptera: Tephritidae, Dacinae). PLoS ONE. MAIN PARTNERS AND COLLABORATING INSTITUTIONS 2017, 12(9): e0184102. Mayo Clinic, Rochester, MN, USA University of Glasgow, Glasgow, Scotland, UK SULOVSKÁ, K., FIŠEROVÁ, E., CHVOSTEKOVÁ, M., ADÁMEK, M. Appropriateness of gait Louisiana State University, Baton Rouge, LA, USA analysis for biometrics: Initial study using FDA method. Measurement. 2017, 105, 1-10.

St. Anne‘s University Hospital Brno International Clinical Research Center

Pekařská 53, 656 91 Brno | Czech Republic | ID: 00159816 Supported by the project no. LQ1605 Translational Medicine Phone: (+420) 543 181 111 | E-mail: [email protected] | www.fnusa-icrc.org from the National Program of Sustainability II (MEYS CR)