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Evan R Daugharthy

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Evan R Daugharthy Evan R Daugharthy Contact Wyss Institute at Harvard Medical School [email protected] Center for Life Sciences Boston [email protected] 3 Blackfan Circle Desk 528/3B (c) 215.687.7232 Boston, MA 02115 USA (w) 617.432.7157 Education Harvard University, Cambridge, MA Ph.D. Candidate, Expected December 2014 Department of Systems Biology, Graduate School of Arts and Sciences University of Pennsylvania, Philadelphia, PA Bachelor of Arts, College of Arts and Sciences, May 2010 Magna Cum Laude with Distinction in Biology Minors in Mathematics, Biophysics, and Science, Technology, & Society Cumulative GPA 3.70, Major GPA 3.76 Saint Thomas Aquinas High School, Overland Park, KS Graduated May 2006, Cumulative GPA 4.0 Awards Graduate Research Fellowship Prize, National Science Foundation, 2013-Present Neysa Cristol Adams Prize in Biology, University of Pennsylvania Department of Biology, 2010 Excellence in Genomics Undergraduate Award, Penn Genome Frontiers Institute, 2010 Phi Beta Kappa, University of Pennsylvania, 2010 Riepe College House Research Fellow, University of Pennsylvania, 2008-2009 University Scholar, University of Pennsylvania, 2007 Provost Mentor Research Fellow, University of Pennsylvania, 2007 National Achievement Scholarship Winner, National Merit Scholarship Corporation, 2006 Publications Lee*, JH, ER Daugharthy*, ... & GM Church. \Highly Multiplexed Subcellular RNA Sequencing in situ." Science 343.6177 (2014): 1360-1363. Marblestone, AH, ER Daugharthy, ... & GM Church. \Rosetta Brains: A Strategy for Molecularly- Annotated Connectomics." arXiv:1404.5103 (2014). Marblestone, AH, ER Daugharthy, ... & GM Church. \Conneconomics: The Economics of Large- Scale Neural Connectomics." bioRxiv (2013). Goodman*, AJ, ER Daugharthy*, J Kim. \Pervasive antisense transcription is evolutionarily conserved in budding yeast." Molecular Biology and Evolution 30.2 (2013): 409-421. * Indicates co-first-authorship. Presentations Harvard Department of Stem Cell and Regenerative Biology Single Cell RNA-Seq Workshop, October 2014 \FISSEQ for in situ transcriptional profiling” Boston, MA GeneExpression Systems Epigenomics & Metabolomics Meeting, August 2014 \RNA sequencing in situ" Boston, MA International Conference on the Systems Biology of Human Disease, June 2014 \In situ sequencing: A multi-plex multi-omic multi-scale technology" (selected lightning talk) Boston, MA Gene Expression and RNA Series, Dept. of Biological Chemistry and Molecular Pharmacology, May 2014 \Fluorescent in situ RNA sequencing: A powerful new transcriptomic tool" Boston, MA NIH NHGRI Centers of Excellence in Genomic Science 11th Annual Grantee Meeting, October 2013 \Fluorescent in situ RNA sequencing (FISSEQ)" Madison, WI Society for the Study of Evolution Conference, June 2010 \Conserved Antisense Transcription in Natural Strains of Yeast" Portland, OR 1 of 3 Posters International Conference on the Systems Biology of Human Disease, June 2014 \In situ sequencing: A multi-plex multi-omic multi-scale technology" Boston, MA Winter q-bio, February 2013 \RNA sequencing in situ: A new tool for multiplex single-cell tran- scriptomics" Honolulu, HA DARPA CLIO Kickoff Meeting, November 2011 \Genetic systems for detecting escape and misuse of microbes" Seattle, WA Research Development of Fluorescent in situ Sequencing Technology Advised by Dr. George M. Church, January 2012 to Present Department of Genetics, Harvard Medical School • Co-developed fluorescent in situ sequencing (FISSEQ) technology • Responsible for implementation of sequencing chemistry and in situ sequencing; developed data analysis pipeline including image processing, base calling, short read alignment, and spatial analysis of gene expression • Continuing to develop next-generation FISSEQ library construction for deeper per-cell in situ sequencing, advanced automation, spatial bioinformatic methods, and multi-omic ap- proaches to measuring the genome, transcriptome, and proteome simultaneously in situ • Applying in situ sequencing to cancer biology to study spatial architecture of tumor and genetic architecture of cancer cell types Yeast Transcriptomics using RNA-Seq Advised by Dr. Junhyong Kim, May 2008 to September 2011 Department of Biology, University of Pennsylvania • Identifying evolutionarily conserved antisense transcription in order to test hypotheses about the function of antisense transcription in gene regulation • Responsible for experimental design, all wetlab work and sequencing, and assisted in de- signing and programming the computational analysis pipeline Genomics Research in Diverse African Human Populations Advised by Dr. Sarah Tishkoff, August 2009 to September 2011 Departments of Genetics and Biology, University of Pennsylvania Color Vision Research • Identifying the genetic basis of phenotypic differences in color perception among African populations • Responsible for data entry, database design and data curation, development and implemen- tation of computational analysis, and genetic analysis Transcriptomics Research • RNA-seq profiling whole-blood transcriptomes of diverse Africans in order to understand how genetic and environmental variation influences common variable physiologic traits and address questions of fundamental biomedical and clinical importance in under-represented African populations • Responsible for design and implementation of RNA sequencing and assisting with subse- quent data analysis Independent Research in Philosophy of Science Approved by Drs. Karen Detlefsen and Kok-Chor Tan, May 2008 to January 2009 Department of Philosophy, University of Pennsylvania • Researching modularity and self-organizational principles of life Research on Imprinted microRNAs Advised by Dr. Marisa Bartolomei, June 2007 to May 2009 Department of Developmental and Cell Biology, University of Pennsylvania • Attempted to identify the regulatory targets of microRNAs at imprinted H19/IGF2 locus in mouse and human tissues • Sole student researcher responsible for all wetlab work, and assisted in experimental design 2 of 3 Teaching Systems Biology 204: Biomolecular Engineering and Synthetic Biology Teaching Fellow, Fall 2014 Responsible for class organization and assisting with student projects Systems Biology 306qc: Quantitative Methods for Biologists Guest lecturer on image processing, Fall 2014 Teaching Assistant, Summer 2012 and Summer 2014 Systems Biology 201: Special Topics in Developmental Biology Teaching Fellow, Spring 2013 Assisted in re-design of the curriculum through brainstorming and research Student Mentor Mentored an undergraduate student, Summer 2014 Oversaw rotation students, Fall 2013 and Fall 2014 Service Political Campaign Volunteer Active throughout the 2012 election cycle, engaging citizens personally about issues, such as funding, that influence American scientific progress and leadership Co-Editor-in-Chief of PennScience PennScience is a peer-reviewed undergraduate science research journal published once each semester by the Science and Technology Wing of the University of Pennsylvania Responsible for overseeing all departments including editing, layout, business, publicity, and website, January 2009 to January 2010 School of Arts and Sciences Student Technology Advisory Board Member Worked with school administrators on computer donation program to give seniors' unwanted computers to local schools and charities, September 2008 to May 2010 President of Penn Stem Cell Club Penn Stem Cell Club (PSCC) is an educational organization (not an advocacy group) that promotes de-stigmatization of stem cell research through outreach at local high schools, debates and speeches on campus, and annual bone marrow drive, May 2008 to May 2009 ActionAIDS Volunteer Partnered with a local buddy suffering from AIDS and diabetes; dealt with issues of safety, drug abuse, and mental health, and gained experience working with terminal patients, October 2007 to December 2008 References Dr. George M. Church Dr. Junhyong Kim Dr. Sarah Tishkoff Department of Genetics Department of Biology Depts. of Genetics & Biology 238 New Research Building 103H Carolyn Lynch Laboratories 430 Clinical Research Building 77 Avenue Louis Pasteur 433 South University Avenue 415 Curie Boulevard Boston, MA 02115 USA Philadelphia PA, 19104 USA Philadelphia PA 19104 USA [email protected] [email protected] tishkoff@mail.med.upenn.edu 3 of 3.
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