Great Ormond Street Hospital for Children NHS Foundation Trust: Information for Families Dihydrotestosterone (Adractim®) 2.5% gel for topical application

This information sheet should be read in conjunction with any information provided by the manufacturer.

This information sheet explains what andractim 2.5% gel is, how it is used and some of the possible side effects. Each person reacts differently to medicines, so your child will not necessarily suffer every side effect mentioned. If you have any questions or concerns, please ask your doctor, nurse or pharmacist or telephone one of the contact numbers on this information sheet.

What is dihydrotestosterone? How is it used? Dihydrotestosterone is a synthetic version of a Dihydrotestosterone 2.5% gel is for external hormone called testosterone. It is available as use only. It should be applied over the a 2.5% gel under the brand name Adractim®, required area of skin after washing. The gel which is imported from abroad. It is used for should be left to dry for five minutes or so children with hormone deficiencies. It works before putting on clothes. by correcting the hormone deficiency, either 1. Put on a pair of gloves in a particular part of the body or affecting 2. Gently squeeze the gel onto the mark on the body as a whole the ruler illustrated below – as instructed on the dispensing label. 3. Spread over the required area evenly 4. Leave for five minutes 5. Wipe this laminated information sheet with a damp piece of kitchen paper ready for the next dose. Remove the gloves and wash them in warm soapy water ready for the next dose. Note: Dihydrotestosterone 2.5% gel should not be applied to any broken areas of skin.

1.251 25 g ooff geg l 2.52 g of gel

StarSta t squeezing gell from this end 2 1 5 60mg 55mg 50mg 45mg 40m g 40m 40 35m g 3 30mg 25m g 20m g 20m 20 15m g 10m g 10m 1 5mg 0mg 0m 0 60 55m 50m 45m 45 30 62. 5 6 57. 5 5 52. 5 5 47. 5 4 42. 5 4 37. 5 37. 5 32. 5 3 27. 5 27. 5 22. 5 2 17. 5 17 12. 5 1 7. 5 7 2. 5 2 2 7 2 7 2 2 2 2 .5 .5 5 5 m 5 m 0m 0 0m .5 . .5 .5 .5 .5 .5 . .5 .5 .5 m m m m m m m m m m m g g

of dihydrotestosterone

Sheet 1 of 2 Ref: 2015F0390 © GOSH NHS Foundation Trust January 2016 Who should not use Dihydrotestosterone 2.5% gel Dihydrotestosterone 2.5% gel? and other medicines People who are hypersensitive to Dihydrotestosterone is applied externally so it Dihydrotestosterone or its excipients (Carbomer should not react with any other medicines. 934, triethanolamine, Alcohol 95%) should Important information discuss using this medicine with their doctor. nnAs this is a specialist treatment, GOSH or your local hospital will supply your child’s What are the side effects? medicine. The following side effects are rare and are nnKeep medicines in a safe place where usually due to the dose being too high, so will children cannot reach them. disappear when the dosage is reduced. nnKeep the gel at room temperature, away nnMood swings and irritability from bright light or direct sunlight and away from heat. Do not store in the fridge. nnExcessive energy or signs of being hyperactive nnIf the doctor decides that your child should stop using dihydrotestosterone, return any nnWeight gain remaining gel to your pharmacist. Do not nnExtra hair growth throw away. nnHoarseness nnOily skin nnAcne

Useful numbers GOSH switchboard: 020 7405 9200 Endocrinology Clinical Nurse Specialists: 020 7813 8214 Pharmacy medicines information: 020 7829 8608 from Monday to Friday from 9am to 5pm

Compiled by the Pharmacy department in collaboration with the Child and Family Information Group Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London WC1N 3JH www.gosh.nhs.uk

Sheet 2 of 2 Ref: 2015F0390 © GOSH NHS Foundation Trust January 2016